ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV2091 good U KOG1607 Intracellular trafficking, secretion, and vesicular transport Protein transporter of the TRAM (translocating chain-associating membrane) superfamily
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV2091 737117 736011 -369
(369 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
SPAC1A6.09c [U] KOG1607 Protein transporter of the TRAM (translo... 196 5e-50
YKL008c [U] KOG1607 Protein transporter of the TRAM (translocati... 150 3e-36
SPBC3E7.15c [U] KOG1607 Protein transporter of the TRAM (translo... 148 1e-35
YHL003c [U] KOG1607 Protein transporter of the TRAM (translocati... 135 1e-31
At1g13580 [U] KOG1607 Protein transporter of the TRAM (transloca... 108 1e-23
At3g25540 [U] KOG1607 Protein transporter of the TRAM (transloca... 105 1e-22
CE27675 [U] KOG1607 Protein transporter of the TRAM (translocati... 102 7e-22
At3g19260 [U] KOG1607 Protein transporter of the TRAM (transloca... 100 3e-21
Hs20550645 [U] KOG1607 Protein transporter of the TRAM (transloc... 98 2e-20
7290690 [U] KOG1607 Protein transporter of the TRAM (translocati... 91 2e-18
Hs13375717 [U] KOG1607 Protein transporter of the TRAM (transloc... 89 1e-17
Hs9937998 [U] KOG1607 Protein transporter of the TRAM (transloca... 82 2e-15
CE04706 [U] KOG1607 Protein transporter of the TRAM (translocati... 73 8e-13
Hs22044511 [U] KOG1607 Protein transporter of the TRAM (transloc... 71 2e-12
ECU08g1350 [U] KOG1607 Protein transporter of the TRAM (transloc... 68 2e-11
CE18517 [U] KOG1608 Protein transporter of the TRAM (translocati... 66 7e-11
CE18518 [U] KOG1608 Protein transporter of the TRAM (translocati... 64 3e-10
Hs6912450 [U] KOG1608 Protein transporter of the TRAM (transloca... 60 4e-09
Hs20532972 [U] KOG1607 Protein transporter of the TRAM (transloc... 60 4e-09
Hs20481895 [U] KOG1607 Protein transporter of the TRAM (transloc... 60 4e-09
7290103 [U] KOG1608 Protein transporter of the TRAM (translocati... 60 7e-09
Hs7657655 [U] KOG1608 Protein transporter of the TRAM (transloca... 59 1e-08
Hs17444463 [U] KOG1608 Protein transporter of the TRAM (transloc... 59 1e-08
CE20184 [U] KOG1607 Protein transporter of the TRAM (translocati... 55 2e-07
Hs11641421 [U] KOG1607 Protein transporter of the TRAM (transloc... 51 2e-06
>SPAC1A6.09c [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 390
Score = 196 bits (498), Expect = 5e-50
Identities = 106/296 (35%), Positives = 161/296 (53%), Gaps = 5/296 (1%)
Query: 74 YTKKFVNLQYEYPDNPGKYDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGRNRFHMRS 133
Y + F+ L Y+ PD G Y G D + +++VF R ++++V +P N + +R+
Sbjct: 92 YAEPFIFLSYKQPD--GSYGKGPKDACFPIFWVIVFTAFRVIVMDYVFRPFVLN-WGVRN 148
Query: 134 VKSLQRFGEQGWSMIYYLFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGLFKTYYLFQ 193
K + RF EQG+S YYL W G Y+Y S Y+ N + ++ +P +S LFK YYL Q
Sbjct: 149 RKVIIRFCEQGYSFFYYLCFWFLGLYIYRSSNYWSNEEKLFEDYPQYYMSPLFKAYYLIQ 208
Query: 194 IASWFHQIIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXX 253
+ W QI+VL++E+RR D WQMFAHHI+T AL SY + F R+GN
Sbjct: 209 LGFWLQQILVLHLEQRRADHWQMFAHHIVTCALIILSYGFNFLRVGNAILYIFDLSDYIL 268
Query: 254 SFAKMLKYCGYSTLCDYMFVVFLFWWVMLRHVVYNYLTYQTWLRAKNLMADGECIAGLAQ 313
S KMLKY G+ +CDY+F +F+ WV RH +++ + A ++ G +
Sbjct: 269 SGGKMLKYLGFGKICDYLFGIFVASWVYSRHYLFSKILRVVVTNAPEII--GGFHLDVPN 326
Query: 314 KRCWTPTVVNIFLALLGGLQVITCIWMYLILKVLVKVIKGIGAEDVRSDEEDENSD 369
+ + F+ LL LQ++ IW +I+KV +V G A D RSD+E E+ +
Sbjct: 327 GYIFNKPIYIAFIILLFTLQLLIYIWFGMIVKVAYRVFSGEEATDSRSDDEGEDEE 382
>YKL008c [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 418
Score = 150 bits (379), Expect = 3e-36
Identities = 97/309 (31%), Positives = 155/309 (49%), Gaps = 14/309 (4%)
Query: 67 GNSFYPEYTKKFVNLQYEYPDNPGKYDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGR 126
GN+ +FV + Y+ D Y GI+D + +++ F +R FL++ V++P
Sbjct: 102 GNTTKTNVLHRFVAVSYQIGDT-NAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAI 160
Query: 127 NRFHMRSVKSLQRFGEQGWSMIYYLFSWIFGFYLYYHSP-YYFNIDHIYSGWPHDQLSGL 185
R H+ S ++R EQ +++ Y S FG Y YHS ++FN +Y +P L
Sbjct: 161 -RLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFL 219
Query: 186 FKTYYLFQIASWFHQ--IIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXX 243
FK +YL Q A W Q I+VL +E+ RKD ++ HHI+T+ L SY ++FT++G
Sbjct: 220 FKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIY 279
Query: 244 XXXXXXXXXXSFAKMLKYCGYSTLCDYMFVVFLFWWVMLRHVVYNYLTYQTWLRAKNLMA 303
SF+K L Y S L + F +F+ W+ LRH + + W
Sbjct: 280 ITMDVSDFLLSFSKTLNYLD-SGLAFFSFAIFVVAWIYLRHYINLKI---LWSVLTQFRT 335
Query: 304 DGECIAGLA--QKRCWTPTVVNIFLALLGGLQVITCIWMYLILKVLVKVI-KGIGAEDVR 360
+G + A Q +CW + I L+G LQ++ W++LI +VL +++ +GI +D
Sbjct: 336 EGNYVLNFATQQYKCWIS--LPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRS 393
Query: 361 SDEEDENSD 369
E DE SD
Sbjct: 394 DSESDEESD 402
>SPBC3E7.15c [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 384
Score = 148 bits (374), Expect = 1e-35
Identities = 92/299 (30%), Positives = 157/299 (51%), Gaps = 13/299 (4%)
Query: 74 YTKKFVNLQYEYPD-NPGKYDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGRNRFHMR 132
Y K + L Y P NP +Y G D L + + F R F+++ ++ +GR+ F++R
Sbjct: 80 YIKYGIFLSYPIPGTNPAQYGKGRLDIAFCLFYALFFTFCREFIMQEIIARIGRH-FNIR 138
Query: 133 SVKSLQRFGEQGWSMIYYLFSWIFGFYLYYHSP-YYFNIDHIYSGWPHDQLSGLFKTYYL 191
+ L+RF EQ ++ +Y+ +G Y+ +P ++FN D + +PH G FK +YL
Sbjct: 139 APAKLRRFEEQAYTCLYFTVMGSWGLYVMKQTPMWFFNTDAFWEEYPHFYHVGSFKAFYL 198
Query: 192 FQIASWFHQ--IIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXX 249
+ A W Q +++L +E+ RKDF ++ HHIIT+ L SYY++FT IG
Sbjct: 199 IEAAYWIQQALVLILQLEKPRKDFKELVVHHIITLLLIGLSYYFHFTWIGLAVFITMDTS 258
Query: 250 XXXXSFAKMLKYCGYSTLCDY-MFVVFLFWWVMLRHVVYNYLTYQTWLRAKNLMA-DGEC 307
+ +K L Y +T+ Y +FV+F+F W+ +RH + + + W + + + D +
Sbjct: 259 DIWLALSKCLNY--VNTVIVYPIFVIFVFVWIYMRHYLNFKIMWAVWGTMRTINSFDLDW 316
Query: 308 IAGLAQKRCWTPTVVNIFLALLGGLQVITCIWMYLILKVLVKVIKGIGAEDVRSDEEDE 366
A Q +CW ++ L LL LQ++ W+ LIL++ + D RS++EDE
Sbjct: 317 AA--EQYKCWISR--DVTLILLTALQLVNIYWLILILRIGYRAFTTNDTHDERSEDEDE 371
>YHL003c [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 411
Score = 135 bits (340), Expect = 1e-31
Identities = 89/296 (30%), Positives = 148/296 (49%), Gaps = 13/296 (4%)
Query: 78 FVNLQYEYPDNPGKYDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGRNRFHMRSVKSL 137
FV + Y+ D Y GI D + +++ F +R FL++ V++P ++ S
Sbjct: 113 FVAISYQV-DGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPF-TVYLNVTSEHRQ 170
Query: 138 QRFGEQGWSMIYYLFSWIFGFYLYYHSPYY-FNIDHIYSGWPHDQLSGLFKTYYLFQIAS 196
+R EQ +++ Y S FG Y+ YHS + F +Y +P LFK +YL Q A
Sbjct: 171 KRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAF 230
Query: 197 WFHQ--IIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXS 254
W Q ++VL +E+ RKD+ ++ HHI+T+ L SY ++FT++G S
Sbjct: 231 WAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLS 290
Query: 255 FAKMLKYCGYSTLCDYMFVVFLFWWVMLRHVVYNYLTYQTWLRAKNLMADGECIAGLA-- 312
+K L Y S ++F +F+F+W+ LRHVV + W +G + A
Sbjct: 291 LSKTLNYLN-SVFTPFVFGLFVFFWIYLRHVVNIRI---LWSVLTEFRHEGNYVLNFATQ 346
Query: 313 QKRCWTPTVVNIFLALLGGLQVITCIWMYLILKVLVKVIKGIGAEDVRSDEEDENS 368
Q +CW + I L+ LQ++ W++LIL++L ++I +D RSD + + S
Sbjct: 347 QYKCWIS--LPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDES 400
>At1g13580 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 308
Score = 108 bits (271), Expect = 1e-23
Identities = 84/291 (28%), Positives = 127/291 (42%), Gaps = 29/291 (9%)
Query: 98 DGYVILTFIVVFCLVRSFLLEFVLKPV------GRNRFHM-----RSVKSLQRFGEQGWS 146
D V+ F V F +R L FV + + G++R M K +++F E W
Sbjct: 22 DFRVLPLFAVFFPSIRFLLDRFVFEKLAKYLIYGKHRQDMGDDTTERKKKIRKFKESAWK 81
Query: 147 MIYYLFSWIFGFYLYYHSPYYFNIDHIYSG-----WPHDQLSGLFKTYYLFQIASWFHQI 201
+YYL + I + Y+ P++ N + + G WP Q K Y+F + + I
Sbjct: 82 CVYYLSAEILALSVTYNEPWFMNTKYFWVGPGDQTWPDQQTKLKLKLLYMFVAGFYTYSI 141
Query: 202 IVLNV-EERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAKMLK 260
L E RR DF HHI T+ L SY F+R+G+ KM K
Sbjct: 142 FALVFWETRRSDFGVSMGHHIATLILIVLSYVCSFSRVGSVVLALHDASDVFLEVGKMSK 201
Query: 261 YCGYSTLCDYMFVVFLFWWVMLRHVVYNY--LTYQTWLRAKNLMADGECIAGLAQKRCWT 318
Y G + + F++F+ W++LR + Y + L ++ L D I G
Sbjct: 202 YSGAERIASFSFILFVLSWIILRLIYYPFWILWSTSYEVVLELDKDKHPIEG-------- 253
Query: 319 PTVVNIFLALLGGLQVITCIWMYLILKVLVKVIKGIG--AEDVRSDEEDEN 367
P +F LL L V+ W L+ ++LVK I+ G +EDVRSD E E+
Sbjct: 254 PIYYYMFNTLLYCLLVLHIYWWVLMYRMLVKQIQDRGKLSEDVRSDSEGED 304
>At3g25540 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 310
Score = 105 bits (262), Expect = 1e-22
Identities = 86/314 (27%), Positives = 134/314 (42%), Gaps = 36/314 (11%)
Query: 80 NLQYEYPDNPGKYDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPV------GRN------ 127
++ +E P D+G + F V F +R L FV + + GR
Sbjct: 9 SIDWEQESFPTYQDLGF-----LPLFAVFFPTIRFLLDRFVFEKLASLVIYGRMSTNKSD 63
Query: 128 --RFHMRSVKSLQRFGEQGWSMIYYLFSWIFGFYLYYHSPYYFNIDHIYSG-----WPHD 180
+ ++ +++F E W IYYL + + + Y+ P++ N + + G WP
Sbjct: 64 NIKDRKKNSPKVRKFKESAWKCIYYLSAELLALSVTYNEPWFSNTLYFWIGPGDQIWPDQ 123
Query: 181 QLSGLFKTYYLFQIASWFHQIIVLNV-EERRKDFWQMFAHHIITVALTTGSYYYYFTRIG 239
+ K Y+F + + I L E RR DF HHI T+ L SY TR G
Sbjct: 124 PMKMKLKFLYMFAAGFYTYSIFALVFWETRRSDFGVSMGHHITTLVLIVLSYICRLTRAG 183
Query: 240 NXXXXXXXXXXXXXSFAKMLKYCGYSTLCDYMFVVFLFWWVMLRHVVYNYLTYQTWLRAK 299
+ KM KYCG +L FV+F WV+LR + Y + + W +
Sbjct: 184 SVILALHDASDVFLEIGKMSKYCGAESLASISFVLFALSWVVLRLIYYPF--WILWSTSY 241
Query: 300 NLMADGECIAGLAQKRCWTPTVVNIFLALLGGLQVITCIWMYLILKVLVKVIKGIG--AE 357
++ + +K P + +F LL L V+ W LI ++LVK ++ G +E
Sbjct: 242 QIIMTVD-----KEKHPNGPILYYMFNTLLYFLLVLHIFWWVLIYRMLVKQVQDRGKLSE 296
Query: 358 DVRSDEE--DENSD 369
DVRSD E DE+ D
Sbjct: 297 DVRSDSESDDEHED 310
>CE27675 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 368
Score = 102 bits (255), Expect = 7e-22
Identities = 57/236 (24%), Positives = 113/236 (47%), Gaps = 5/236 (2%)
Query: 133 SVKSLQRFGEQGWSMIYYLFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGLFKTYYLF 192
SV ++ E W YY F++++G Y+ +S + +++ + G+P + YY+
Sbjct: 85 SVSRAKKILECFWRFSYYTFAFLYGLYVMKNSSWLYDVKQCWIGYPFHPVPDTIWWYYMI 144
Query: 193 QIASWFHQIIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXX 252
+ ++ +I + RR DFWQ+ HH+IT+ L + S+ F R+G
Sbjct: 145 ETGFYYSLLIGSTFDVRRSDFWQLMVHHVITIFLLSSSWTINFVRVGTLILLSHDVSDVF 204
Query: 253 XSFAKMLKYCGYS-TLCDYMFVVFLFWWVMLRHVVYNYLTYQTWL-RAKNLMADGECIAG 310
K+++Y ++ + ++MFV+F WV R + Y ++ ++ + A L+ +
Sbjct: 205 LEGGKLVRYDAHNKNMTNFMFVLFFSSWVATRLIYYPFIVIRSAVTEAAALIQPDYILWD 264
Query: 311 LAQKRCWTPTVVNIFLALLGGLQVITCIWMYLILKVLVKVIKGIGAEDVRSDEEDE 366
+ P ++ L LL L + W ++IL++ + G A+DVRSD + +
Sbjct: 265 YQLSPPYAPRLIVFALILLFFLHI---FWTFIILRIAYRTSTGGQAKDVRSDSDSD 317
>At3g19260 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 296
Score = 100 bits (250), Expect = 3e-21
Identities = 77/276 (27%), Positives = 123/276 (43%), Gaps = 18/276 (6%)
Query: 99 GYVILTFIV---VFCLVRSFLLEFVLKPVGRNRFHMRSVKSLQRFGEQGWSMIYYLFSWI 155
G+ L ++ VF + +LL P+ N R+ + + E W ++YY
Sbjct: 31 GFFFLRLVLDRYVFQRIALWLLSTGSAPIKLNDAATRA--KIVKCKESLWKLLYYAACDF 88
Query: 156 FGFYLYYHSPYYFNIDHIYSGWPHDQLSGLFKTYYLFQIASWFHQIIVLNV-EERRKDFW 214
F + YH P+ +I + GWP+ +L K YY+ Q + + + L E RRKDF
Sbjct: 89 FVLQVIYHEPWARDIKLYFHGWPNQELKLSIKLYYMCQCGFYVYGVAALLAWETRRKDFA 148
Query: 215 QMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAKMLKYCGYSTLCDYMFVV 274
M +HH+IT+ L + SY F RIG AK+ KY F +
Sbjct: 149 VMMSHHVITIILLSYSYLTSFFRIGAIILALHDASDVFMETAKIFKYSEKEFGASVCFAL 208
Query: 275 FLFWWVMLRHVVYNYLTYQTW-LRAKNLMADGECIAGLAQKRCWTPTVVNIFLALLGGLQ 333
F W++LR + + + W +RA ++ E + L + F +L L
Sbjct: 209 FAVSWLLLRLIYFPF-----WIIRATSI----ELLDYLDMTSAEGTLMYYSFNTMLLMLL 259
Query: 334 VITCIWMYLILKVLVKVIKGIG--AEDVRSDEEDEN 367
V W YLI ++V+++K G ED+RSD ED++
Sbjct: 260 VFHIYWWYLICAMIVRLLKNRGKVGEDIRSDSEDDD 295
>Hs20550645 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 328
Score = 98.2 bits (243), Expect = 2e-20
Identities = 60/226 (26%), Positives = 103/226 (45%), Gaps = 13/226 (5%)
Query: 126 RNRFHMRSVKSLQRFGEQGWSMIYYLFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGL 185
R+R + +L +F E W +YL + +G + SP++++I + +P LS
Sbjct: 46 RHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSG 105
Query: 186 FKTYYLFQIASWFHQIIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXX 245
YY+ ++A ++ + + +RKDF MF HH++T+ L + SY R+G
Sbjct: 106 LYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVGTLIMCL 165
Query: 246 XXXXXXXXSFAKMLKYCGYSTLCDYMFVVFLFWWVMLRHVVYNYLTYQTWLRAKNLMADG 305
AK+ Y Y LCD +FV+F +++ R +Y + W+ L
Sbjct: 166 HDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPF-----WILNTTLFESW 220
Query: 306 ECIAGLAQKRCWTPTVVNIFLALLGGLQVITCIWMYLILKVLVKVI 351
E I A W + LL LQ++ IW YLI ++ +K +
Sbjct: 221 EIIGPYAS--WW------LLNGLLLTLQLLHVIWSYLIARIALKAL 258
>7290690 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 339
Score = 91.3 bits (225), Expect = 2e-18
Identities = 60/235 (25%), Positives = 103/235 (43%), Gaps = 50/235 (21%)
Query: 136 SLQRFGEQGWSMIYYLFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGLFKTYYLFQIA 195
+L +F E W IYYL+S+IFG + + P+++++ + G+PH
Sbjct: 106 TLVKFCENTWRCIYYLYSFIFGVIVLWDKPWFWDVKSCWYGYPH---------------- 149
Query: 196 SWFHQIIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXSF 255
QMF HH++T+ L + S+ R+G+
Sbjct: 150 -------------------QMFIHHMVTLLLMSLSWVCNLHRVGSLVLVVHDCADIFLEA 190
Query: 256 AKMLKYCGYSTLCDYMFVVFLFWWVMLRHVVYNYLTYQTWLRAKNLMADGECIAGLAQKR 315
AK+ KY Y LCD +F +F W++ R Y + Y + + A ++
Sbjct: 191 AKLTKYAKYQKLCDAIFAIFTVVWIVTRLGFYPRIIYSSSVEAPRILP------------ 238
Query: 316 CWTPTVVNIFLALLGGLQVITCIWMYLILKVLVKVI-KGIGAEDVRSDEEDENSD 369
IF +LL L V+ IW Y+ILK++V + KG+ + D+RS + ++ +D
Sbjct: 239 --MFPAYYIFNSLLLMLLVLHVIWTYMILKIVVDSLQKGLMSGDIRSSDSEDLTD 291
>Hs13375717 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 394
Score = 88.6 bits (218), Expect = 1e-17
Identities = 63/245 (25%), Positives = 109/245 (43%), Gaps = 16/245 (6%)
Query: 126 RNRFHMRSVKSLQRFGEQGWSMIYYLFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGL 185
R R + + ++F E W ++YL S++ G + YH + + + +P+ L
Sbjct: 119 RRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPS 178
Query: 186 FKTYYLFQIASWFHQIIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXX 245
+YL ++ + +I L + +RKDF + HH + V L T SY RIG+
Sbjct: 179 LYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLL 238
Query: 246 XXXXXXXXSFAKMLKYCGYSTLCDYMFVVFLFWWVMLRHVVY-NYLTYQTWLRAKNLMAD 304
KM+ Y Y +CD +F++F F + R V++ + Y T+ +++
Sbjct: 239 HDSSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYY--ESISNR 296
Query: 305 GECIAGLAQKRCWTPTVVNIFLALLGGLQVITCIWMYLILKVLVKVI-KGIGAEDVRSDE 363
G F LL LQ++ W LIL++L + KG +D+RSD
Sbjct: 297 GPFFG------------YYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDV 344
Query: 364 EDENS 368
E+ +S
Sbjct: 345 EESDS 349
>Hs9937998 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 230
Score = 81.6 bits (200), Expect = 2e-15
Identities = 48/200 (24%), Positives = 91/200 (45%), Gaps = 13/200 (6%)
Query: 165 PYYFNIDHIYSGWPHDQLSGLFKTYYLFQIASWFHQIIVLNVEERRKDFWQMFAHHIITV 224
P+++++ ++ G+P YY+ +++ ++ + + + +RKDF + HH+ T+
Sbjct: 8 PWFYDMKKVWEGYPIQSTIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATI 67
Query: 225 ALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAKMLKYCGYSTLCDYMFVVFLFWWVMLRH 284
L + S++ + R G AKM Y G+ C+ +F+VF +++ R
Sbjct: 68 ILISFSWFANYIRAGTLIMALHDSSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITRL 127
Query: 285 VVYNYLTYQTWLRAKNLMADGECIAGLAQKRCWTPTVVNIFLALLGGLQVITCIWMYLIL 344
V+ + W+ L+ E F +++G LQ++ W YLIL
Sbjct: 128 VILPF-----WILHCTLVYPLELYPAFFG--------YYFFNSMMGVLQLLHIFWAYLIL 174
Query: 345 KVLVKVIKGIGAEDVRSDEE 364
++ K I G ED RSD E
Sbjct: 175 RMAHKFITGKLVEDERSDRE 194
>CE04706 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 368
Score = 72.8 bits (177), Expect = 8e-13
Identities = 45/166 (27%), Positives = 71/166 (42%), Gaps = 5/166 (3%)
Query: 203 VLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAKMLKYC 262
+L ++ +R DFWQM HH IT+AL S+ R+G K+L+Y
Sbjct: 191 ILFLDAKRSDFWQMLVHHFITLALIGVSWTMNMVRVGTLILVSHDAVDILIDVGKILRYE 250
Query: 263 GYSTLCDYMFVVFLFWWVMLRHVVYNY-LTYQTWLRAKNLMADGECIAGLAQKRCWTPTV 321
+ T F LF WV R V Y + + W A L+ D Q+ P
Sbjct: 251 QFETALTICFAGVLFVWVATRLVYYPFWIIRSVWFDAPALIQDDYEWLNFDQQ----PQA 306
Query: 322 VNIFLALLGGLQVITCIWMYLILKVLVKVIKGIGAEDVRSDEEDEN 367
+ LL L ++ W Y++ K+ I+ +DVR D ++++
Sbjct: 307 PRFIMLLLTALLILHIFWAYILFKIAYDTIQEGVVDDVREDFDEQS 352
>Hs22044511 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 192
Score = 71.2 bits (173), Expect = 2e-12
Identities = 47/162 (29%), Positives = 73/162 (45%), Gaps = 14/162 (8%)
Query: 209 RRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAKMLKYCGYSTLC 268
+RKDF MF HH++++ L T SY R+G AKM Y + +C
Sbjct: 9 KRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMC 68
Query: 269 DYMFVVFLFWWVMLRHVVYNYLTYQTWLRAKNLMADGECIAGLAQKRCWTPTVVNIFLAL 328
D +FV+F ++ R + + W+ L E + W V N+ L L
Sbjct: 69 DLLFVMFAVVFITTRLGI-----FPLWVLNTTLFESWEIVGPYPS---W--WVFNLLLLL 118
Query: 329 LGGLQVITCIWMYLILKVLVKVI-KGIGAEDVRSDEEDENSD 369
+ GL C W YLI+K+ K + +G ++D RSD E + +
Sbjct: 119 VQGL---NCFWSYLIVKIACKAVSRGKVSKDDRSDIESSSDE 157
>ECU08g1350 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 287
Score = 67.8 bits (164), Expect = 2e-11
Identities = 60/284 (21%), Positives = 111/284 (38%), Gaps = 29/284 (10%)
Query: 93 DIGIDDGYVILTFI---------VVFCLVRSFLLEFVLKPVGRNRFHMRSVKS------L 137
DI ID G + T +VF L+ + + ++ P ++
Sbjct: 5 DISIDSGRIFETHFRFPRDICLTMVFSLLITMVKNLIVLPTASALIKRLGLEKDLGSEKK 64
Query: 138 QRFGEQGWSMIYYLFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGLFKTYYLFQIASW 197
++F W ++Y F+ ++G+++ P + ++ W +Y + + +
Sbjct: 65 KKFCISLWKAMFYSFTSVYGYFVIRSEPRAYTAKNLMDTWGVHGAPSKVLFFYHLEFSYY 124
Query: 198 FHQIIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAK 257
F ++ L E KDF QM HHI+T+ L SY+ R G K
Sbjct: 125 FVELFYLFSEHAYKDFLQMVTHHIVTMLLLFLSYHNDLLRAGVAIIVIHDISDPFLEIGK 184
Query: 258 MLKYCGYSTLCDYMFVVFLFWWVMLRHVVYNYLTYQTWLRAKNLMADGECIAGLAQKRCW 317
+ Y +L +F F ++ R +Y +L I + +
Sbjct: 185 LTNYIHDKSLATSIFTCFAGIFIASRLGIYAFLLSLP-------------IVVSMWEHGF 231
Query: 318 TPTVVNIFLALLGGLQVITCIWMYLILKVLVKVIKGIGAEDVRS 361
+P++ I + LL GLQ + +W +I+++ KVI ED+RS
Sbjct: 232 SPSLFLIAM-LLQGLQAMHIVWSLMIVRMARKVIHETELEDIRS 274
>CE18517 [U] KOG1608 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 371
Score = 66.2 bits (160), Expect = 7e-11
Identities = 52/212 (24%), Positives = 97/212 (45%), Gaps = 8/212 (3%)
Query: 92 YDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGRNRFHMRSVKSLQRFGEQGWSMIYYL 151
Y GI D I + V + +V + + E+ L + + + H+ V + +FGE M + +
Sbjct: 79 YLSGILDLPAIFFYSVCWIVVHAVVQEYGLDKISK-KTHLSKVSTF-KFGESFHQMFFTV 136
Query: 152 FSWIFGFYLYYHSPYYFN-IDHIYSGWP--HDQLSGLFKTYYLFQIASWFHQIIVLNVEE 208
+S FY+ F+ + ++ G+P H +S +K Y++FQI+ W HQ +++
Sbjct: 137 YSIAHAFYIVSERLEDFSEVKSVWLGYPTEHRVMSAAYKLYFIFQISYWIHQFPEFYLQK 196
Query: 209 -RRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAKMLKYCGYSTL 267
+R + Q I+ +A + +Y++ FTR+G A+ + G L
Sbjct: 197 LKRDEIRQKSVQAILHIAFISIAYFFNFTRVGLALITLEYITQLIFHIARFAHFVGRKGL 256
Query: 268 CDYMFVVF--LFWWVMLRHVVYNYLTYQTWLR 297
D F +F F V L ++ +T+ LR
Sbjct: 257 SDPAFKLFNGSFVLVRLGSIIIAVMTFWYGLR 288
>CE18518 [U] KOG1608 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 373
Score = 64.3 bits (155), Expect = 3e-10
Identities = 52/214 (24%), Positives = 94/214 (43%), Gaps = 10/214 (4%)
Query: 92 YDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGRNRFHMRSVKSLQRFGEQGWSMIYYL 151
Y GI D I + V + +V + + E+ L + + + H+ V + +FGE M + +
Sbjct: 79 YLSGILDLPAIFFYSVCWIVVHAVVQEYGLDKISK-KTHLSKVSTF-KFGESFHQMFFTV 136
Query: 152 FSWIFGFYLYYHSPYYFNIDHIYSGW-----PHDQLSGLFKTYYLFQIASWFHQIIVLNV 206
+S FY+ F+ +S W H +S +K Y++FQI+ W HQ +
Sbjct: 137 YSIAHAFYIVSERLEDFSEVKSFSVWLGYPTEHRVMSAAYKLYFIFQISYWIHQFPEFYL 196
Query: 207 EE-RRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAKMLKYCGYS 265
++ +R + Q I+ +A + +Y++ FTR+G A+ + G
Sbjct: 197 QKLKRDEIRQKSVQAILHIAFISIAYFFNFTRVGLALITLEYITQLIFHIARFAHFVGRK 256
Query: 266 TLCDYMFVVF--LFWWVMLRHVVYNYLTYQTWLR 297
L D F +F F V L ++ +T+ LR
Sbjct: 257 GLSDPAFKLFNGSFVLVRLGSIIIAVMTFWYGLR 290
>Hs6912450 [U] KOG1608 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 370
Score = 60.5 bits (145), Expect = 4e-09
Identities = 37/149 (24%), Positives = 73/149 (48%), Gaps = 3/149 (2%)
Query: 92 YDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGRNRFHMRSVKSLQRFGEQGWSMIYYL 151
Y G D IL +I + ++ + + E++L + + R H+ VK +F E G ++++
Sbjct: 68 YHYGPKDLVTILFYIFITIILHAVVQEYILDKISK-RLHLSKVKH-SKFNESGQLVVFHF 125
Query: 152 FSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGLFKTYYLFQIASWFHQIIVLNVEE-RR 210
S I+ FY+ Y N ++ +PH L K +YL Q+A W H + L ++ R+
Sbjct: 126 TSVIWCFYVVVTEGYLTNPRSLWEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQKVRK 185
Query: 211 KDFWQMFAHHIITVALTTGSYYYYFTRIG 239
++ + + + + G+Y +R+G
Sbjct: 186 EEIPRQLQYICLYLVHIAGAYLLNLSRLG 214
>Hs20532972 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 252
Score = 60.5 bits (145), Expect = 4e-09
Identities = 26/114 (22%), Positives = 58/114 (50%)
Query: 126 RNRFHMRSVKSLQRFGEQGWSMIYYLFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGL 185
R R + L++F E W +YL ++I G + P+++++ ++ G+P
Sbjct: 119 RRRRNQDRPSLLKKFREASWRFTFYLIAFIAGMAVIVDKPWFYDMKKVWEGYPIQSTIPS 178
Query: 186 FKTYYLFQIASWFHQIIVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIG 239
YY+ +++ ++ + + + +RKDF + HH+ T+ L + S++ + R G
Sbjct: 179 QYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILISFSWFANYIRAG 232
>Hs20481895 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 293
Score = 60.5 bits (145), Expect = 4e-09
Identities = 45/188 (23%), Positives = 84/188 (43%), Gaps = 15/188 (7%)
Query: 165 PYYFNIDHIYSGWPHDQLSGLFKTYYLFQIASWFHQIIVLNVEERRKDFWQMFAHHIITV 224
P+ +++ +++G+P L YY+ +++ ++ + L + +RKDF HH+ +
Sbjct: 71 PWLYDLWEVWNGYPKQPLLPSQYWYYILEMSFYWSLLFRLGFDVKRKDFLAHIIHHLAAI 130
Query: 225 ALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAKMLKYCGYSTLCDYMFVVFLFWWVMLRH 284
+L + S+ + R G AKM Y G++ C+ +F +F + + R
Sbjct: 131 SLMSFSWCANYIRSGTLVMIVHDVADIWLESAKMFSYAGWTQTCNTLFFIFSTIFFISRL 190
Query: 285 VVYNYLTYQTWLRAKNLMADGECIAGLAQKRCWTPTVVNIFLAL-LGGLQVITCIWMYLI 343
+V+ + W+ L+ + P IFL L L LQV+ W Y I
Sbjct: 191 IVFPF-----WILYCTLILPMYHL---------EPFFSYIFLNLQLMILQVLHLYWGYYI 236
Query: 344 LKVLVKVI 351
LK+L + I
Sbjct: 237 LKMLNRCI 244
>7290103 [U] KOG1608 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 368
Score = 59.7 bits (143), Expect = 7e-09
Identities = 38/152 (25%), Positives = 72/152 (47%), Gaps = 4/152 (2%)
Query: 89 PGKYDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGRNRFHMRSVKSLQRFGEQGWSMI 148
P Y GI D I + + ++ + + EFVL + + + H+ K L RF E G +
Sbjct: 76 PYTYIAGIKDYCAIFFYTLTCIIMHAIIQEFVLDKISK-KLHLSKFK-LARFNESGQLVA 133
Query: 149 YYLFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGLFKTYYLFQIASWFHQIIVLNVE- 207
+YL S+++G ++ Y + ++ G+P +S L K Y++ Q+A + H + L +
Sbjct: 134 FYLLSFVWGAHVLLKEGYLGQVAQLWEGFPDHPMSFLHKFYFVVQLAYYLHMLPELYFQK 193
Query: 208 -ERRKDFWQMFAHHIITVALTTGSYYYYFTRI 238
+ +++ H I L +Y F R+
Sbjct: 194 IKTKEEQQPKIVHSISGFTLIVLAYTLSFQRL 225
>Hs7657655 [U] KOG1608 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 374
Score = 58.9 bits (141), Expect = 1e-08
Identities = 34/144 (23%), Positives = 69/144 (47%), Gaps = 11/144 (7%)
Query: 78 FVNLQY---------EYPDNPGKYDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGRNR 128
FV LQY + ++ Y GI D + +++V ++ + + E++L + R R
Sbjct: 50 FVTLQYNVTLPATEEQATESVSLYYYGIKDLATVFFYMLVAIIIHAVIQEYMLDKINR-R 108
Query: 129 FHMRSVKSLQRFGEQGWSMIYYLFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGLFKT 188
H K +F E G +YLF+ ++G ++ Y + ++ +PH+ ++ K
Sbjct: 109 MHFSKTKH-SKFNESGQLSAFYLFACVWGTFILISENYISDPTILWRAYPHNLMTFQMKF 167
Query: 189 YYLFQIASWFHQIIVLNVEERRKD 212
+Y+ Q+A W H L ++ +K+
Sbjct: 168 FYISQLAYWLHAFPELYFQKTKKE 191
>Hs17444463 [U] KOG1608 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 369
Score = 58.9 bits (141), Expect = 1e-08
Identities = 36/150 (24%), Positives = 72/150 (48%), Gaps = 5/150 (3%)
Query: 92 YDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVGRNRFHMRSVKSLQ-RFGEQGWSMIYY 150
Y G+ D + +++V ++ + + E+VL + + M+ K+ Q +F E G ++Y
Sbjct: 73 YYYGVKDLATVFFYMLVAIIIHATIQEYVLDKINKR---MQFTKAKQNKFNESGQFSVFY 129
Query: 151 LFSWIFGFYLYYHSPYYFNIDHIYSGWPHDQLSGLFKTYYLFQIASWFHQIIVLNVEERR 210
FS I+G ++ + I+ PH ++ K +Y+ Q+A WFH L ++ +
Sbjct: 130 FFSCIWGTFILISENCLSDPTLIWKARPHSMMTFQMKFFYISQLAYWFHAFPELYFQKTK 189
Query: 211 K-DFWQMFAHHIITVALTTGSYYYYFTRIG 239
K D + + + + TG+Y Y +G
Sbjct: 190 KQDIPRQLVYIGLHLFHITGAYLLYLNHLG 219
>CE20184 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 360
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/237 (22%), Positives = 88/237 (36%), Gaps = 30/237 (12%)
Query: 72 PEYTKKFVNLQ--YEYPDNP----GKYDIGIDDGYVILTFIVVFCLVRSFLLEFVLKPVG 125
P + +++ L+ Y +P + K + + Y +L +F +R +L ++
Sbjct: 33 PHWFRRYARLRPDYSFPSSMISDFKKVSLSNSELYTVLILASIFTFLRYYLQ---IRLES 89
Query: 126 RNRFHMRSVKSLQRFGEQGWSMIYYLFSWIFGFYLY--------YHSPYYFNIDHIYSGW 177
+ H + + E W + YY WIF FY + ++ P I+ G
Sbjct: 90 WTQQHNIYPRFAHKVPESFWKLTYYGTVWIFAFYFHMCVDSHDIFNDPLSMWIEWESGGR 149
Query: 178 PHDQLSGLFKTYYLFQIASWFHQIIV-LNVEERRKDFWQMFAHHIITVALTTGSYYYYFT 236
P ++ + Y Q A + H I L ++ RKD W MF HH I + L SY FT
Sbjct: 150 P--KMHWQVQVIYAVQSAFYIHSIYATLFMDLWRKDSWLMFVHHFIALGLLFLSYVDNFT 207
Query: 237 RIGNXXXXXXXXXXXXXSFAKMLKYCGYSTLCDY----------MFVVFLFWWVMLR 283
G K+ Y T Y F++F WV+ R
Sbjct: 208 LPGALVLFLHDNSDATLEITKLSFYLKKRTNRQYYKYYFLMGNAAFILFAIIWVIFR 264
>Hs11641421 [U] KOG1607 Protein transporter of the TRAM (translocating
chain-associating membrane) superfamily
Length = 350
Score = 51.2 bits (121), Expect = 2e-06
Identities = 55/230 (23%), Positives = 86/230 (36%), Gaps = 36/230 (15%)
Query: 142 EQGWSMIYYLFSWIFGFYLYYHS--PYYFNIDHIYSGW-PHDQLSGLFKTYYLFQIASWF 198
E W ++YL SW + YL + + P++ + ++ W P + YL Q + +
Sbjct: 101 ESAWKFLFYLGSWSYSAYLLFGTDYPFFHDPPSVFYDWTPGMAVPRDIAAAYLLQGSFYG 160
Query: 199 HQI-IVLNVEERRKDFWQMFAHHIITVALTTGSYYYYFTRIGNXXXXXXXXXXXXXSFAK 257
H I L ++ RKD M HH++T+ L SY + + +G F K
Sbjct: 161 HSIYATLYMDTWRKDSVVMLLHHVVTLILIVSSYAFRYHNVGILVLFLHDISDVQLEFTK 220
Query: 258 MLKYCG---------YSTLCDYMFVVFLFWWVMLRHVVYNYLTYQTWLRAKNLMADGECI 308
+ Y ++ D + F F W R +Y W K L A C
Sbjct: 221 LNIYFKSRGGSYHRLHALAADLGCLSFGFSWFWFR--LY-------WFPLKVLYATSHCS 271
Query: 309 AGLAQKRCWTPTVVNI-----FLALLGGLQVITCIWMYLILKVLVKVIKG 353
TV +I F ALL L ++ W I+ KV+ G
Sbjct: 272 ---------LRTVPDIPFYFFFNALLLLLTLMNLYWFLYIVAFAAKVLTG 312
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.328 0.142 0.461
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,569,328
Number of Sequences: 60738
Number of extensions: 865687
Number of successful extensions: 2830
Number of sequences better than 1.0e-05: 25
Number of HSP's better than 0.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 2772
Number of HSP's gapped (non-prelim): 26
length of query: 369
length of database: 30,389,216
effective HSP length: 108
effective length of query: 261
effective length of database: 23,829,512
effective search space: 6219502632
effective search space used: 6219502632
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)