ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV2095 good K KOG0794 Transcription CDK8 kinase-activating protein cyclin C
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV2095 738725 737814 -304
(304 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL025c [K] KOG0794 CDK8 kinase-activating protein cyclin C 426 e-119
Hs4885119 [K] KOG0794 CDK8 kinase-activating protein cyclin C 129 5e-30
SPBC12D12.06 [K] KOG0794 CDK8 kinase-activating protein cyclin C 128 1e-29
7299935 [K] KOG0794 CDK8 kinase-activating protein cyclin C 127 3e-29
At5g48630 [K] KOG0794 CDK8 kinase-activating protein cyclin C 110 2e-24
At5g48640 [K] KOG0794 CDK8 kinase-activating protein cyclin C 99 1e-20
SPBC32F12.06 [D] KOG0834 CDK9 kinase-activating protein cyclin T 81 2e-15
7290261 [R] KOG0835 Cyclin L 81 2e-15
Hs18583591 [D] KOG0834 CDK9 kinase-activating protein cyclin T 76 7e-14
CE20970 [K] KOG0794 CDK8 kinase-activating protein cyclin C 75 2e-13
Hs4502623 [DKL] KOG2496 Cdk activating kinase (CAK)/RNA polymera... 71 2e-12
Hs9945320 [R] KOG0835 Cyclin L 71 2e-12
7302150 [D] KOG0834 CDK9 kinase-activating protein cyclin T 70 4e-12
At5g45190 [D] KOG0834 CDK9 kinase-activating protein cyclin T 69 6e-12
7296498 [DKL] KOG2496 Cdk activating kinase (CAK)/RNA polymerase... 65 2e-10
YPR025c [DKL] KOG2496 Cdk activating kinase (CAK)/RNA polymerase... 62 8e-10
Hs4502629 [D] KOG0834 CDK9 kinase-activating protein cyclin T 61 2e-09
Hs17978469 [D] KOG0834 CDK9 kinase-activating protein cyclin T 61 2e-09
At4g19600 [D] KOG0834 CDK9 kinase-activating protein cyclin T 60 5e-09
7293966 [D] KOG0834 CDK9 kinase-activating protein cyclin T 58 1e-08
At1g27630 [D] KOG0834 CDK9 kinase-activating protein cyclin T 57 3e-08
Hs17978466 [D] KOG0834 CDK9 kinase-activating protein cyclin T 56 6e-08
CE10334 [D] KOG0834 CDK9 kinase-activating protein cyclin T 55 2e-07
SPBP16F5.02 [DKL] KOG2496 Cdk activating kinase (CAK)/RNA polyme... 53 6e-07
>YNL025c [K] KOG0794 CDK8 kinase-activating protein cyclin C
Length = 323
Score = 426 bits (1096), Expect = e-119
Identities = 209/319 (65%), Positives = 251/319 (78%), Gaps = 23/319 (7%)
Query: 1 MSASYWDSSQRHKWKYTRESLAKEKQKLWLLECQLFPQGLNVTIHDSKAN---KQVTTNI 57
MS S+W S+QRH W+YT+ SLAKE+QKLWLLECQLFPQGLN+ + DSK N + +T NI
Sbjct: 1 MSGSFWTSTQRHHWQYTKASLAKERQKLWLLECQLFPQGLNIVM-DSKQNGIEQSITKNI 59
Query: 58 PVTQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYL 117
P+T RDLHYD+DYNLRIYCYFLIMKLGRRLNIRQ AL TAH+YLSRFL++ASVRE+NLY+
Sbjct: 60 PITHRDLHYDKDYNLRIYCYFLIMKLGRRLNIRQYALATAHIYLSRFLIKASVREINLYM 119
Query: 118 LITTCIYLACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTEFEFYLIEELQSYLIVHH 177
L+TTC+YLACKVEECPQ+IRTLV+EAR+LWPEFIPPD TKVTEFEFYL+EEL+SYLIVHH
Sbjct: 120 LVTTCVYLACKVEECPQYIRTLVSEARTLWPEFIPPDPTKVTEFEFYLLEELESYLIVHH 179
Query: 178 PYRSLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIAISCLF---- 233
PY+SL+QI + L + LS D+LQ WSLINDSY DVHLLY PH+IA++CLF
Sbjct: 180 PYQSLKQIVQVLKQPPFQITLSSDDLQNCWSLINDSYINDVHLLYPPHIIAVACLFITIS 239
Query: 234 -------------AVSCIIHKPEDSTKRANI--NMFIAETQVNLEQVMFILQELISLYDH 278
A S I P++S+ I N F+AE+ V+LE+VM +QE I+LYDH
Sbjct: 240 IHGKPTKGSSLASAASEAIRDPKNSSSPVQIAFNRFMAESLVDLEEVMDTIQEQITLYDH 299
Query: 279 WDKYNELRIRALLHELYLR 297
WDKY+E I+ LLH LYLR
Sbjct: 300 WDKYHEQWIKFLLHTLYLR 318
>Hs4885119 [K] KOG0794 CDK8 kinase-activating protein cyclin C
Length = 303
Score = 129 bits (324), Expect = 5e-30
Identities = 86/300 (28%), Positives = 147/300 (48%), Gaps = 56/300 (18%)
Query: 1 MSASYWDSSQRHKWKYTRESLAKEKQKLWLLECQLFPQGLNVTIHDSKANKQVTTNIPVT 60
M+ ++W SS +W ++ L KE+QK
Sbjct: 21 MAGNFWQSSHYLQWILDKQDLLKERQK--------------------------------D 48
Query: 61 QRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYLLIT 120
+ L + + L+I+ +I LG L +RQ + TA VY RF R S++ ++ L+
Sbjct: 49 LKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAP 108
Query: 121 TCIYLACKVEECPQHIRT-LVNEARSL--------WPEFIPPDVTKVTEFEFYLIEELQS 171
TC++LA KVEE T L+ A S+ +P+ P + + E EFYL+E +
Sbjct: 109 TCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDC 168
Query: 172 YLIVHHPYRSLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIAISC 231
LIV+HPYR L Q + + E D L W ++ND+Y TD+ LLY P +IA++C
Sbjct: 169 CLIVYHPYRPLLQYVQDMGQE-------DMLLPLAWRIVNDTYRTDLCLLYPPFMIALAC 221
Query: 232 LFAVSCIIHKPEDSTKRANINMFIAETQVNLEQVMFILQELISLYDHWDKYNELRIRALL 291
L V+C++ ++ + + AE V++E+++ I++ ++ LY+ W ++E + A +
Sbjct: 222 LH-VACVV-------QQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATI 273
>SPBC12D12.06 [K] KOG0794 CDK8 kinase-activating protein cyclin C
Length = 228
Score = 128 bits (321), Expect = 1e-29
Identities = 77/204 (37%), Positives = 113/204 (54%), Gaps = 15/204 (7%)
Query: 74 IYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVRE-VNLYLLITTCIYLACKVEEC 132
IY + ++ G RL +RQ L TA V L R++L+ + + +L L+ TCIYL+CKVEEC
Sbjct: 33 IYQWKVVQTFGDRLRLRQRVLATAIVLLRRYMLKKNEEKGFSLEALVATCIYLSCKVEEC 92
Query: 133 PQHIRTLVNEARSLWPEFIPPDVTKVTEFEFYLIEELQSYLIVHHPYRSLEQIEKALSSE 192
P HIRT+ NEA LW + + ++E EF +I L ++LIVHHPY SLEQ A
Sbjct: 93 PVHIRTICNEANDLWSLKVKLSRSNISEIEFEIISVLDAFLIVHHPYTSLEQ---AFHDG 149
Query: 193 KYNYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIAISCLFAVSCIIHKPEDSTKRANIN 252
N K +L+ WS++NDSY + + L+ PH +A + L C D +
Sbjct: 150 IINQK----QLEFAWSIVNDSYASSLCLMAHPHQLAYAALLISCC-----NDENTIPKLL 200
Query: 253 MFIAETQVNLEQVMFILQELISLY 276
I T + +V+ +Q +IS+Y
Sbjct: 201 DLIKST--DAFKVILCVQRIISIY 222
>7299935 [K] KOG0794 CDK8 kinase-activating protein cyclin C
Length = 267
Score = 127 bits (318), Expect = 3e-29
Identities = 93/296 (31%), Positives = 143/296 (47%), Gaps = 61/296 (20%)
Query: 1 MSASYWDSSQRHKWKYTRESLAKEKQKLWLLECQLFPQGLNVTIHDSKANKQVTTNIPVT 60
M+ ++W SS +W + L +E+Q HD A
Sbjct: 1 MAGNFWQSSHSQQWILDKPDLLRERQ------------------HDLLA----------- 31
Query: 61 QRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYLLIT 120
L+ D + I+ +I LG +L +RQ + TA VY RF R S++ ++ LL
Sbjct: 32 ---LNEDEYQKVFIFFANVIQVLGEQLKLRQQVIATATVYFKRFYARNSLKNIDPLLLAP 88
Query: 121 TCIYLACKVEE------------CPQHIRTLVNEARSLWPEFIPPDVTKVTEFEFYLIEE 168
TCI LA KVEE C I+T + A + + P + E EFYL+E
Sbjct: 89 TCILLASKVEEFGVISNSRLISICQSAIKTKFSYA---YAQEFPYRTNHILECEFYLLEN 145
Query: 169 LQSYLIVHHPYRSLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIA 228
L LIV+ PYR L Q+ + + E D L W ++NDS TDV LLY P+ IA
Sbjct: 146 LDCCLIVYQPYRPLLQLVQDMGQE-------DQLLTLSWRIVNDSLRTDVCLLYPPYQIA 198
Query: 229 ISCLFAVSCIIHKPEDSTKRANINMFIAETQVNLEQVMFILQELISLYDHWDKYNE 284
I+CL ++C+I + +D+TK+ + AE V+L++V I++ +++LY+ W + E
Sbjct: 199 IACL-QIACVILQ-KDATKQ-----WFAELNVDLDKVQEIVRAIVNLYELWKDWKE 247
>At5g48630 [K] KOG0794 CDK8 kinase-activating protein cyclin C
Length = 253
Score = 110 bits (276), Expect = 2e-24
Identities = 69/236 (29%), Positives = 121/236 (51%), Gaps = 17/236 (7%)
Query: 61 QRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYLLIT 120
QR + + ++++ I KL + + IRQ + TA Y+ R R S+ E L+
Sbjct: 29 QRGISVEDFRLIKLHMSNYISKLAQHIKIRQRVVATAVTYMRRVYTRKSLTEYEPRLVAP 88
Query: 121 TCIYLACKVEECPQHIRTLVNEARSLW-PEFIPPDVTKVTEFEFYLIEELQSYLIVHHPY 179
TC+YLACK EE H + LV + L+ E ++ + E E ++E L YL+V HPY
Sbjct: 89 TCLYLACKAEESVVHAKLLVFYMKKLYADEKFRYEIKDILEMEMKVLEALNFYLVVFHPY 148
Query: 180 RSLEQIEKALSSEKYNYKLSDDELQKI-WSLINDSYTTDVHLLYSPHVIAISCLFAVSCI 238
RSL + + + ++D + + W L+ND+Y D+ L++ P +I ++C++ S
Sbjct: 149 RSLPEFLQ-------DSGINDTSMTHLTWGLVNDTYRMDLILIHPPFLITLACIYIAS-- 199
Query: 239 IHKPEDSTKRANINMFIAETQVNLEQVMFILQELISLYDHWDKYNELRIRALLHEL 294
+HK +D I + E V++ V I E++ Y++ + E R+ A ++L
Sbjct: 200 VHKEKD------IKTWFEELSVDMNIVKNIAMEILDFYENHRLFTEERVHAAFNKL 249
>At5g48640 [K] KOG0794 CDK8 kinase-activating protein cyclin C
Length = 259
Score = 98.6 bits (244), Expect = 1e-20
Identities = 65/227 (28%), Positives = 114/227 (49%), Gaps = 25/227 (11%)
Query: 80 IMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYLLITTCIYLACKVEECPQHIRTL 139
IMKL + + +RQ + TA Y+ R +R S+ E L+ TC+YLA K EE R L
Sbjct: 48 IMKLAQHIKVRQRVVATAITYMRRVYIRKSMVEFEPRLVALTCLYLASKAEESIVQARNL 107
Query: 140 VNEARSL------WP-EFIPPDVTKVTEFEFYLIEELQSYLIVHHPYRSLEQI--EKALS 190
V + L +P E+ ++ + E ++E L YL+V HPYRSL + + AL+
Sbjct: 108 VFYIKRLCNIFFFYPDEYNKYELKDILGMEMKVLEALDYYLVVFHPYRSLSEFLQDAALN 167
Query: 191 SEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIAISCLFAVSCIIHKPEDSTKRAN 250
N Q W ++ND+Y D+ L++ P+ IA++C++ S +H+ +D
Sbjct: 168 DVNMN--------QITWGIVNDTYKMDLILVHPPYRIALACIYIAS--VHREKD------ 211
Query: 251 INMFIAETQVNLEQVMFILQELISLYDHWDKYNELRIRALLHELYLR 297
I + + ++ V I E++ Y+++ E ++ + +L L+
Sbjct: 212 ITAWFEDLHEDMNLVKNIAMEILDFYENYRTITEEKVNSAFSKLALK 258
>SPBC32F12.06 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 342
Score = 81.3 bits (199), Expect = 2e-15
Identities = 69/232 (29%), Positives = 113/232 (47%), Gaps = 27/232 (11%)
Query: 57 IPVTQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLY 116
IP+ Q ++ + N I+ +G RL + Q AL TA++Y RF LR S++ + Y
Sbjct: 35 IPLDQEEIQRSKGCNF-------IINVGLRLKLPQTALATANIYFHRFYLRFSLKNYHYY 87
Query: 117 LLITTCIYLACKVEECPQHIRTLVNEARSLWPE---FIPPDVTK--------VTEFEFYL 165
+ TCI+LA KVE+ + +R +V + + + + TK + E L
Sbjct: 88 EVAATCIFLATKVEDSVRKLRDIVINCAKVAQKNSNVLVDEQTKEYWRWRDVILYTEEVL 147
Query: 166 IEELQSYLIVHHPY-RSLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSP 224
+E L V HPY L I+K ++ +K K++ W+ INDS + LLYSP
Sbjct: 148 LEALCFDFTVEHPYPYVLSFIKKFVADDKNVTKVA-------WTYINDSTRSIACLLYSP 200
Query: 225 HVIAISCLFAVSCIIHKPEDSTKRANINMFIAETQVNLEQVMFILQELISLY 276
IA + F + ++ ST + +++ E+QV+ E V +L + SLY
Sbjct: 201 KTIA-AAAFQFALEKNEINLSTTTDGLPVWMEESQVSYEDVKGVLTLIDSLY 251
>7290261 [R] KOG0835 Cyclin L
Length = 560
Score = 80.9 bits (198), Expect = 2e-15
Identities = 54/189 (28%), Positives = 92/189 (48%), Gaps = 18/189 (9%)
Query: 58 PVTQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYL 117
P +Q L ++ + +LRI LI G L + Q A+ T V RF S N+
Sbjct: 100 PSSQDGLDHETEKDLRILGCELIQTAGILLRLPQVAMATGQVLFQRFFYSKSFVRHNMET 159
Query: 118 LITTCIYLACKVEECPQHIRTLVN---------EARSLWPEFIPPDVT----KVTEFEFY 164
+ +C+ LA K+EE P+ IR ++N + + P + P T +V + E
Sbjct: 160 VAMSCVCLASKIEEAPRRIRDVINVFHHIKQVRAQKEISPMVLDPYYTNLKMQVIKAERR 219
Query: 165 LIEELQSYLIVHHPYRSLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSP 224
+++EL + V HP++ + + L EK+ + +Q W+ +NDS TDV + Y+P
Sbjct: 220 VLKELGFCVHVKHPHKLIVMYLQVLQYEKH-----EKLMQLSWNFMNDSLRTDVFMRYTP 274
Query: 225 HVIAISCLF 233
IA +C++
Sbjct: 275 EAIACACIY 283
>Hs18583591 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 354
Score = 75.9 bits (185), Expect = 7e-14
Identities = 60/235 (25%), Positives = 111/235 (46%), Gaps = 21/235 (8%)
Query: 80 IMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYLLITTCIYLACKVEECPQHIRTL 139
I +G RL + L T +Y RF + S ++ Y+ C++LA KVEE P+ + +
Sbjct: 57 IFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDI 116
Query: 140 VNEARSL-----WPEFIPPDVTKVTEFEFYLIEELQSYLIVHHPYRSLEQIEKALSSEKY 194
+ ARSL + +F +V E L++ ++ L V HPY+ L + K L +K
Sbjct: 117 IKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKN 176
Query: 195 NYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIAISCLFAVS--CIIHKPEDSTK---RA 249
+ +Q W+ +NDS T + L + P +IA++ ++ C E ++K R
Sbjct: 177 KIQ---KLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRR 233
Query: 250 NINMFIAETQVNLEQVMFILQELISLYDHWDKYNELRIRALLHELYLRQQTPAIQ 304
F+ + V+ +L+++ + D Y++ + + H + QQ P++Q
Sbjct: 234 WWEQFVQDVPVD------VLEDI--CHQILDLYSQGKQQMPHHTPHQLQQPPSLQ 280
>CE20970 [K] KOG0794 CDK8 kinase-activating protein cyclin C
Length = 327
Score = 74.7 bits (182), Expect = 2e-13
Identities = 64/260 (24%), Positives = 111/260 (42%), Gaps = 53/260 (20%)
Query: 89 IRQCALVTAHVYLSRFLLRASVREVNLYLLITTCIYLACKVEE-----CPQHIRTLVNEA 143
+RQ + TA +Y RF LR S R++ +L+ +T ++LACKVEE ++
Sbjct: 66 LRQQVIATAIIYFKRFYLRQSFRDMCPFLVASTALFLACKVEEHTTLSVSSFLKNTAIVL 125
Query: 144 RSLWPEFIPPDVTK---VTEFEFYLIEELQSYLIVHHPYRSL------EQI--------- 185
W TK V + EF L+E L L+VHH R + +I
Sbjct: 126 PKRWGVTFETTSTKNGVVYDSEFILVEILDCCLVVHHASRPMCPPPPPREIFDKNWNSGI 185
Query: 186 --------------------EKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPH 225
EK + E +N + + + QK+ NDS DV L++ PH
Sbjct: 186 FLIFFLNFLVKKMENCGIFSEKLENFEFFNLEAIEAQCQKV---ANDSLRCDVSLIFPPH 242
Query: 226 VIAISCLFAVSCIIHKPEDSTKRANINMFIAETQVNLEQVMFILQELISLYDHWDKYNEL 285
VI +S + ++ + E+ + ++ E + E+V ++++ +Y W ++E
Sbjct: 243 VIGLSSIMVAMELMGRGEE------LEAWLVEVDTDFEKVTDCVEQIYKMYTLWKSFDEK 296
Query: 286 -RIRALLHELYLRQQTPAIQ 304
++ L+ +L Q P Q
Sbjct: 297 EEVKKLMAKLPKPNQQPPPQ 316
>Hs4502623 [DKL] KOG2496 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK cyclin H subunit
Length = 323
Score = 71.2 bits (173), Expect = 2e-12
Identities = 76/304 (25%), Positives = 133/304 (43%), Gaps = 42/304 (13%)
Query: 5 YWDSSQRHKWKYT-RESLAKEKQKL-WLLECQLFPQGLNVTIHDSKANKQVTTNIPV--- 59
Y +SSQ+ W ++ E LA+ + C+ + AN +V N PV
Sbjct: 2 YHNSSQKRHWTFSSEEQLARLRADANRKFRCK------------AVANGKVLPNDPVFLE 49
Query: 60 TQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYLLI 119
++ + Y R+ + + K ++ + TA +Y RF L SV E + +++
Sbjct: 50 PHEEMTLCKYYEKRLLEFCSVFKPAMPRSV----VGTACMYFKRFYLNNSVMEYHPRIIM 105
Query: 120 TTCIYLACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTEFEFYLIEELQSYLIVHHPY 179
TC +LACKV+E V R P + ++ E+E LI++L +LIVH+PY
Sbjct: 106 LTCAFLACKVDEFNVSSPQFVGNLRES-PLGQEKALEQILEYELLLIQQLNFHLIVHNPY 164
Query: 180 RSLEQIEKALSSEKYNYKLSDDELQKIW-SLINDSYTTDVHLLYSPHVIAISCLFAVSCI 238
R E L + +Y + + L+K +N TD +LLY+P IA++ + +
Sbjct: 165 RPFEGFLIDLKT-RYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILS---- 219
Query: 239 IHKPEDSTKRANINM--------FIAETQVNLEQVMFILQELISLYDHWDKYNELRIRAL 290
S RA I M + E + L Q++ I++ + +L ++ + L
Sbjct: 220 ------SASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVL 273
Query: 291 LHEL 294
+L
Sbjct: 274 KQKL 277
>Hs9945320 [R] KOG0835 Cyclin L
Length = 526
Score = 70.9 bits (172), Expect = 2e-12
Identities = 55/216 (25%), Positives = 98/216 (44%), Gaps = 18/216 (8%)
Query: 40 LNVTIHDSKANKQVTTNIPVTQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHV 99
+++TI S ++ + P Q L + +LRI LI G L + Q A+ T V
Sbjct: 50 VSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQV 109
Query: 100 YLSRFLLRASVREVNLYLLITTCIYLACKVEECPQHIRTLVN---EARSLWPEFIPPDV- 155
RF S + + ++ CI LA K+EE P+ IR ++N R L + P +
Sbjct: 110 LFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLI 169
Query: 156 ---------TKVTEFEFYLIEELQSYLIVHHPYRSLEQIEKALSSEKYNYKLSDDELQKI 206
+V + E +++EL + V HP++ + + L E+ + +Q
Sbjct: 170 LDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECER-----NQTLVQTA 224
Query: 207 WSLINDSYTTDVHLLYSPHVIAISCLFAVSCIIHKP 242
W+ +NDS T+V + + P IA +C++ + + P
Sbjct: 225 WNYMNDSLRTNVFVRFQPETIACACIYLAARALQIP 260
>7302150 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 381
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 8/162 (4%)
Query: 80 IMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYLLITTCIYLACKVEECPQHIRTL 139
IM+ G ++ + + T VY RF + S R Y+ C++ A KVEE P+ R +
Sbjct: 37 IMECGTKMGLGHNTMATGVVYFHRFYMFHSFRSFPRYVTACCCLFFAGKVEETPKKCRDI 96
Query: 140 VNEARSLWPE-----FIPPDVTKVTEFEFYLIEELQSYLIVHHPYRSLEQIEKALSSEKY 194
+ AR + + F +V E L++ ++ L V HPY L + K ++
Sbjct: 97 IKTARGILTDNYFYSFGDDPKEEVMTLERILLQTIKFDLQVEHPYTFLLKYAKCFKGDQQ 156
Query: 195 NYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIAISCLFAVS 236
+ +Q W+ +NDS +T V L + P +IA++ + S
Sbjct: 157 KLQ---KMVQMAWNFVNDSLSTVVCLQWEPEIIAVALIHLAS 195
>At5g45190 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 583
Score = 69.3 bits (168), Expect = 6e-12
Identities = 61/248 (24%), Positives = 111/248 (44%), Gaps = 34/248 (13%)
Query: 51 KQVTTNIPVTQRDLHYDRDYNLR-IYCYFLIMKLGRRLNI----RQCALVTAHVYLSRFL 105
K++ N P + ++ LR YC FL LG RL + Q + TA ++ RF
Sbjct: 38 KEIEENSPSRLDGIDLKKETYLRKSYCTFL-QDLGMRLKVFPISPQVTIATAIIFCHRFF 96
Query: 106 LRASVREVNLYLLITTCIYLACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTEFEFY- 164
R S + + + T C++LA KVEE P+ ++ ++ + + + P K+ + E Y
Sbjct: 97 FRQSHAKNDRRTIATVCMFLAGKVEETPRPLKDVIFVSYEIINKKDPGASQKIKQKEVYE 156
Query: 165 ------------LIEELQSYLIVHHPYRSLEQIEKALSSEKYNYKLSDDELQKI-WSLIN 211
++ L L V+HPY+ L + K +K++ + L ++ W+ +N
Sbjct: 157 QQKELILNGEKIVLSTLGFDLNVYHPYKPLVEAIK-------KFKVAQNALAQVAWNFVN 209
Query: 212 DSYTTDVHLLYSPHVIAISCLFAVSCI--IHKPEDSTKRANINMFIAETQVNLEQVMFIL 269
D T + L + PH IA +F + + P D K ++ E V Q+ +
Sbjct: 210 DGLRTSLCLQFKPHHIAAGAIFLAAKFLKVKLPSDGEK-----VWWQEFDVTPRQLEDVS 264
Query: 270 QELISLYD 277
+++ LY+
Sbjct: 265 NQMLELYE 272
>7296498 [DKL] KOG2496 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK cyclin H subunit
Length = 324
Score = 64.7 bits (156), Expect = 2e-10
Identities = 57/232 (24%), Positives = 103/232 (43%), Gaps = 30/232 (12%)
Query: 8 SSQRHKWKYTRESLAKEKQKLWLLECQLFPQGLNVTIHDSKAN-KQVTTNIPVTQRDLHY 66
SSQ+ W + E L+E ++ + H+ +A + + + + +
Sbjct: 5 SSQKRSWTFANEGQ--------LMEFRVEQNSKYIESHEEEAQGRDLNEHFLTSAEERLL 56
Query: 67 DRDYNLRIYCYFLIMKLGRRLN--IRQCALVTAHVYLSRFLLRASVREVNLYLLITTCIY 124
+ Y + ++ + RR + +C + TA Y RF L S + + ++ TC++
Sbjct: 57 LKQYEIYLFDFC------RRFEPTMPKCVVGTAFHYFKRFYLNNSPMDYHPKEILATCVF 110
Query: 125 LACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTEF----EFYLIEELQSYLIVHHPYR 180
+ACKVEE I VN I D K T+ E LI +L YL +H+P+R
Sbjct: 111 VACKVEEFNVSINQFVNN--------IKGDRNKATDIVLSNELLLIGQLNYYLTIHNPFR 162
Query: 181 SLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIAISCL 232
+E + + + N + D I S I+ +Y +D LL++P IA++ +
Sbjct: 163 PIEGFLIDIKT-RSNMQNPDRLRPHIDSFIDSTYYSDACLLHTPSQIALAAV 213
>YPR025c [DKL] KOG2496 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK cyclin H subunit
Length = 393
Score = 62.4 bits (150), Expect = 8e-10
Identities = 60/239 (25%), Positives = 109/239 (45%), Gaps = 27/239 (11%)
Query: 5 YWDSSQRHKWKYTRESLAKEK-----QKLWLLECQL--FPQGLNVTIHDSKANKQVTTNI 57
Y SSQ W YT++ L +++ + + +E L F + N+T + K + I
Sbjct: 49 YRHSSQYRMWSYTKDQLQEKRVDTNARAIAYIEENLLKFREAHNLTEEEIKVLEAKA--I 106
Query: 58 PVTQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYL 117
P+T + + +L + + + + LN+ + TA + RF L SV +++
Sbjct: 107 PLTMEE-----ELDLVNFYAKKVQVIAQHLNLPTEVVATAISFFRRFFLENSVMQIDPKS 161
Query: 118 LITTCIYLACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTEFEFYLIEELQSYLIVHH 177
++ T I+LACK E + + +A+S V +FEF L+E L+ L+ HH
Sbjct: 162 IVHTTIFLACKSENYFISVDSFAQKAKS--------TRDSVLKFEFKLLESLKFSLLNHH 213
Query: 178 PYRSLEQIEKALSSEKYNYKLSDDELQKIW----SLINDSYTTDVHLLYSPHVIAISCL 232
PY+ L + + Y K+ + + +I+ I + TDV Y+P I ++ L
Sbjct: 214 PYKPLHGFFLDIQNVLYG-KVDLNYMGQIYDRCKKRITAALLTDVVYFYTPPQITLATL 271
>Hs4502629 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 663
Score = 60.8 bits (146), Expect = 2e-09
Identities = 45/187 (24%), Positives = 83/187 (44%), Gaps = 16/187 (8%)
Query: 56 NIPVTQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNL 115
N P + + D++ + R LI ++G+RLN+ Q + TA VY+ RF + S + N
Sbjct: 20 NTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNK 79
Query: 116 YLLITTCIYLACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTEF----------EFYL 165
++ +T ++LA KVEE + + ++ A + P TK + E +
Sbjct: 80 NIISSTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVILETIM 139
Query: 166 IEELQSYLIVHHPYRSLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPH 225
++ L + + HP+ + + + + + K D + N + T L Y P
Sbjct: 140 LQTLGFEITIEHPHTDVVKCTQLVRASK------DLAQTSYFMATNSLHLTTFCLQYKPT 193
Query: 226 VIAISCL 232
VIA C+
Sbjct: 194 VIACVCI 200
>Hs17978469 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 730
Score = 60.8 bits (146), Expect = 2e-09
Identities = 45/187 (24%), Positives = 83/187 (44%), Gaps = 16/187 (8%)
Query: 56 NIPVTQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNL 115
N P + + D++ + R LI ++G+RLN+ Q + TA VY+ RF + S + N
Sbjct: 20 NTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNK 79
Query: 116 YLLITTCIYLACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTEF----------EFYL 165
++ +T ++LA KVEE + + ++ A + P TK + E +
Sbjct: 80 NIISSTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVILETIM 139
Query: 166 IEELQSYLIVHHPYRSLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPH 225
++ L + + HP+ + + + + + K D + N + T L Y P
Sbjct: 140 LQTLGFEITIEHPHTDVVKCTQLVRASK------DLAQTSYFMATNSLHLTTFCLQYKPT 193
Query: 226 VIAISCL 232
VIA C+
Sbjct: 194 VIACVCI 200
>At4g19600 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 533
Score = 59.7 bits (143), Expect = 5e-09
Identities = 59/247 (23%), Positives = 106/247 (42%), Gaps = 44/247 (17%)
Query: 51 KQVTTNIPVTQRDLHYDRDYNLR-IYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRAS 109
K++ N P + ++ LR YC FL LG RL + L+ + + LL +
Sbjct: 38 KEIEENSPSRLDSIDLKKETYLRKSYCTFL-QDLGMRLKVTVLRLLLSPFSMLSSLLTQT 96
Query: 110 VREVNLYLLITTCIYLACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTEFEFYLIEEL 169
+ T C++LA KVEE P+ ++ ++ + + + P K+ + E Y E
Sbjct: 97 IA--------TVCMFLAGKVEETPRPLKDVIVVSYEIIHKKDPTTAQKIKQKEVY---EQ 145
Query: 170 QSYLI----------------VHHPYRSLEQIEKALSSEKYNYKLSDDELQKI-WSLIND 212
Q LI V+HPY+ L + K +K++ + L ++ W+ +ND
Sbjct: 146 QKELILNGEKIVLSTLGFDFNVYHPYKPLVEAIK-------KFKVAQNALAQVAWNFVND 198
Query: 213 SYTTDVHLLYSPHVIAISCLFAVSCI--IHKPEDSTKRANINMFIAETQVNLEQVMFILQ 270
T + L + PH IA +F + + P D K ++ E V Q+ +
Sbjct: 199 GLRTSLCLQFKPHHIAAGAIFLAAKFLKVKLPSDGEK-----VWWQEFDVTPRQLEDVSN 253
Query: 271 ELISLYD 277
+++ LY+
Sbjct: 254 QMLELYE 260
>7293966 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 1097
Score = 58.2 bits (139), Expect = 1e-08
Identities = 52/232 (22%), Positives = 108/232 (46%), Gaps = 22/232 (9%)
Query: 56 NIPVTQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNL 115
N P + + D + R +LI ++G+RL + Q + TA VY+ RF S +
Sbjct: 54 NSPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVYMHRFYAFHSFTHFHR 113
Query: 116 YLLITTCIYLACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTE----FEFYLIEELQS 171
+ + ++LA KVEE P+ + ++ A P + ++ + E L++ L
Sbjct: 114 NSMASASLFLAAKVEEQPRKLEHVIRAANKCLPPTTEQNYAELAQELVFNENVLLQTLGF 173
Query: 172 YLIVHHPY----RSLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPHVI 227
+ + HP+ R+ + ++ + +Y L+ + L + T + L Y P V+
Sbjct: 174 DVAIDHPHTHVVRTCQLVKACKDLAQTSYFLASNSL----------HLTSMCLQYRPTVV 223
Query: 228 AISCLFAVSCIIHKPE--DSTKRANINMFIAETQVNLEQVMFILQELISLYD 277
A C++ ++C + E ST+ + ++ +T V+L+ + + E I++Y+
Sbjct: 224 ACFCIY-LACKWSRWEIPQSTEGKHWFYYVDKT-VSLDLLKQLTDEFIAIYE 273
>At1g27630 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 317
Score = 57.0 bits (136), Expect = 3e-08
Identities = 43/160 (26%), Positives = 76/160 (46%), Gaps = 7/160 (4%)
Query: 75 YCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYLLITTCIYLACKVEECPQ 134
YC FL +LG +L++ Q + A V RF +R S + + + T+ ++LACK E+ P
Sbjct: 64 YCTFL-QRLGMKLHVSQVTISCAMVMCHRFYMRQSHAKNDWQTIATSSLFLACKAEDEPC 122
Query: 135 HIRTLVNEARSLWPEFIPPDVTKVTEFEFY-----LIEELQSYLIVHHPYR-SLEQIEKA 188
+ ++V + + E+ P ++ + E Y +I +S L+ + +E K
Sbjct: 123 QLSSVVVASYEIIYEWDPSASIRIHQTECYHEFKEIILSGESLLLSTSAFHLDIELPYKP 182
Query: 189 LSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIA 228
L++ D W+ ++D T + L Y PHVIA
Sbjct: 183 LAAALNRLNAWPDLATAAWNFVHDWIRTTLCLQYKPHVIA 222
>Hs17978466 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 726
Score = 56.2 bits (134), Expect = 6e-08
Identities = 45/187 (24%), Positives = 83/187 (44%), Gaps = 16/187 (8%)
Query: 56 NIPVTQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNL 115
N P + + D++ + R L+ +G+RLN+ Q + TA VY+ RF + S +
Sbjct: 21 NSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPG 80
Query: 116 YLLITTCIYLACKVEECPQHIRTLVNEARS-LWPEFIPPD---------VTKVTEFEFYL 165
+ ++LA KVEE P+ + ++ A + L P+ PD V + E +
Sbjct: 81 NSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESII 140
Query: 166 IEELQSYLIVHHPYRSLEQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPH 225
++ L L + HP+ + + + + + K D + N + T L Y+P
Sbjct: 141 LQTLGFELTIDHPHTHVVKCTQLVRASK------DLAQTSYFMATNSLHLTTFSLQYTPP 194
Query: 226 VIAISCL 232
V+A C+
Sbjct: 195 VVACVCI 201
>CE10334 [D] KOG0834 CDK9 kinase-activating protein cyclin T
Length = 258
Score = 54.7 bits (130), Expect = 2e-07
Identities = 44/158 (27%), Positives = 75/158 (46%), Gaps = 6/158 (3%)
Query: 79 LIMKLGRRLNIRQCALV-TAHVYLSRFLLRASVREVNLYLLITTCIYLACKVEECPQHIR 137
L+ ++G LN + + A VY RF + S + + + +C++LA KVE+ P+ +
Sbjct: 42 LLSEVGNALNCKPRPTIGVAAVYFHRFYMIHSFQSFSREVTALSCLFLAGKVEDFPKKCK 101
Query: 138 TLVNEARSLWPEFIPPD---VTKVTEFEFYLIEELQSYLIVHHPYRSLEQIEKALSSEKY 194
+ A + +PE V V E L+ L+ L V PY +L ++ +
Sbjct: 102 DVCQAAVTHYPEIYSKYQNLVDDVMGLERVLLHSLKFDLHVALPYDAL--LDYKMMFPDM 159
Query: 195 NYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIAISCL 232
N + D +Q W+ INDS T + + P +IAI+ L
Sbjct: 160 NREKITDAVQIAWTFINDSIYTTLCITTEPQMIAIALL 197
>SPBP16F5.02 [DKL] KOG2496 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK cyclin H subunit
Length = 322
Score = 52.8 bits (125), Expect = 6e-07
Identities = 57/241 (23%), Positives = 112/241 (45%), Gaps = 24/241 (9%)
Query: 1 MSAS-YWDSSQRHKWKYTRESLAKEKQKLWLLECQLFPQGLNVTIHDSKANKQVTTNIPV 59
MSA + DS+ W +T E L+K + K+ + F + + + + + ++ V
Sbjct: 1 MSADKFRDSTHYRDWIFTEEDLSKTRAKV----NEKFTNIVRERMLEELSLQNKEASLEV 56
Query: 60 TQRDLHYDRDYNLRIYCYFLIMKLGRRLNIRQCALVTAHVYLSRFLLRASVREVNLYLLI 119
L + + L Y F + L L++ TA ++ RF L SV E + ++
Sbjct: 57 LPPTLTVEEELELVNYYSFQLNALSSALSLPTHIRSTAILFFKRFYLINSVMEYSPKIIS 116
Query: 120 TTCIYLACKVEECPQHIRTLVNEARSLWPEFIPPDVTKVTEFEFYLIEELQSYLIVHHPY 179
T ++LA K C H ++ +++ P+ P + V E+EF + + L+ L V P+
Sbjct: 117 FTSLFLATK---CNDHYISIEQFCKNM-PKTTPEE---VLEYEFNVCQSLKWDLYVWLPF 169
Query: 180 RSL-------EQIEKALSSEKYNYKLSDDELQKIWSLINDSYTTDVHLLYSPHVIAISCL 232
R L + + ++ EK+ Y+ D L K + ++ +D++ L+SP +IA+ +
Sbjct: 170 RPLQGFLLDCQTVLPKVAVEKF-YECHD--LSK--KFLIETLHSDIYFLHSPSIIALGAI 224
Query: 233 F 233
+
Sbjct: 225 Y 225
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.324 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,860,576
Number of Sequences: 60738
Number of extensions: 711684
Number of successful extensions: 2745
Number of sequences better than 1.0e-05: 24
Number of HSP's better than 0.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 2694
Number of HSP's gapped (non-prelim): 30
length of query: 304
length of database: 30,389,216
effective HSP length: 106
effective length of query: 198
effective length of database: 23,950,988
effective search space: 4742295624
effective search space used: 4742295624
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)