ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV2137 good E KOG0785 Amino acid transport and metabolism Isocitrate dehydrogenase, alpha subunit
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV2137 750670 751776 369
(369 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIL094c [E] KOG0785 Isocitrate dehydrogenase alpha subunit 583 e-166
SPAC31G5.04 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 425 e-119
At5g03290 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 222 8e-58
7293593 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 216 4e-56
Hs5031777 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 211 1e-54
At3g09805 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 206 3e-53
CE10354 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 202 6e-52
SPAC11G7.03 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 187 3e-47
SPBC902.05c [E] KOG0785 Isocitrate dehydrogenase alpha subunit 184 1e-46
At4g35650 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 184 1e-46
At4g35260 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 183 3e-46
At2g17130 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 183 4e-46
YNL037c [E] KOG0784 Isocitrate dehydrogenase gamma subunit 179 8e-45
YOR136w [E] KOG0785 Isocitrate dehydrogenase alpha subunit 178 1e-44
At5g14200 [E] KOG0786 3-isopropylmalate dehydrogenase 166 5e-41
Hs4758582 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 166 7e-41
CE08620 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 163 4e-40
At1g31180 [E] KOG0786 3-isopropylmalate dehydrogenase 162 6e-40
At1g80560 [E] KOG0786 3-isopropylmalate dehydrogenase 160 2e-39
Hs5901982 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 150 2e-36
7300799 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 149 5e-36
7301367 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 144 3e-34
CE16887 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 143 5e-34
CE00970 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 142 6e-34
YCL018w [E] KOG0786 3-isopropylmalate dehydrogenase 139 9e-33
SPBC1A4.02c [E] KOG0786 3-isopropylmalate dehydrogenase 107 3e-23
7291785 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 91 4e-18
YDL066w [C] KOG1526 NADP-dependent isocitrate dehydrogenase 54 5e-07
SPAC6G10.08 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 53 8e-07
At1g65930 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 52 1e-06
At1g54340 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 51 2e-06
CE03436 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 50 7e-06
>YIL094c [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 371
Score = 583 bits (1504), Expect = e-166
Identities = 293/371 (78%), Positives = 336/371 (89%), Gaps = 3/371 (0%)
Query: 1 MMRTRFIQLSR-RAYASNA--KNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFI 57
M R+ +LS R ASNA K+LTIGLIPGDGIGKEVIPAGK++LE+LN K+GLSF FI
Sbjct: 1 MFRSVATRLSACRGLASNAARKSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFI 60
Query: 58 DLQAGWETFQNTGKALPDETIDILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLF 117
DL AG++TFQ TGKALPDET+ +LK QC+GALFGAVQSPTTKVEGYSSPIVALR+ +GLF
Sbjct: 61 DLYAGFQTFQETGKALPDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLF 120
Query: 118 ANVRPVKSVDGTKDRKVDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKN 177
ANVRPVKSV+G K + +D+VIVRENTEDLYIK+EK+YID+ATGTRVADATKRI+EIAT+
Sbjct: 121 ANVRPVKSVEGEKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRR 180
Query: 178 IATIALQIAQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQ 237
IATIAL IA +RL+ G ATLTVTHKSNVLSQSDGLFRE+C+E YE+NKDKYG ++YNEQ
Sbjct: 181 IATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQ 240
Query: 238 IVDSMVYRMFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPCHG 297
IVDSMVYR+FREP+CFDV+VAPNLYGDILSDGAAALVGSLGVVPSANVGP IVIGEPCHG
Sbjct: 241 IVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHG 300
Query: 298 SAPDIAGKGISNPIATIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTT 357
SAPDIAGKGI+NPIATIRSTALMLEFLG+ E A+DI+KAVDAN+REG TPDLGG ++T
Sbjct: 301 SAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDANLREGSIKTPDLGGKAST 360
Query: 358 QQVLEDVLSKL 368
QQV++DVLS+L
Sbjct: 361 QQVVDDVLSRL 371
>SPAC31G5.04 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 362
Score = 425 bits (1092), Expect = e-119
Identities = 215/361 (59%), Positives = 274/361 (75%), Gaps = 10/361 (2%)
Query: 16 SNAKNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPD 75
S + + +GLIP DGIGKEV+PA ++++E+L K+ L F FIDL AGW TF+ TGKALP+
Sbjct: 2 SATRRIVLGLIPADGIGKEVVPAARRLMENLPAKHKLKFDFIDLDAGWGTFERTGKALPE 61
Query: 76 ETIDILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDRKVD 135
T++ LK +C ALFGAVQSPT KV GYSSPIVALRK +GL+ANVRPVKS+DG K + VD
Sbjct: 62 RTVERLKTECNAALFGAVQSPTHKVAGYSSPIVALRKKMGLYANVRPVKSLDGAKGKPVD 121
Query: 136 LVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQ--QRLEQN 193
LVIVRENTE LY+K E+ + G RVA+A +RI+E A+ I +A +IA+ Q++ ++
Sbjct: 122 LVIVRENTECLYVK-EERMVQNTPGKRVAEAIRRISEEASTKIGKMAFEIAKSRQKIRES 180
Query: 194 GHATL------TVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMF 247
G ++ T+ HKSNV+S +DGLFRE CR + Y + +EQIVDSMVYR+F
Sbjct: 181 GTYSIHKKPLVTIIHKSNVMSVTDGLFRESCRHAQSLDPS-YASINVDEQIVDSMVYRLF 239
Query: 248 REPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPCHGSAPDIAGKGI 307
REPECFDVVVAPNLYGDILSDGAA+L+GSLG+VPSANVG N V+ EP HGSAPDIAG+GI
Sbjct: 240 REPECFDVVVAPNLYGDILSDGAASLIGSLGLVPSANVGDNFVMSEPVHGSAPDIAGRGI 299
Query: 308 SNPIATIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSK 367
+NP+AT RS ALMLEF+G+ + A DI+ AVD + EGK LTPDLGG S T ++ + VL+
Sbjct: 300 ANPVATFRSVALMLEFMGHQDAAADIYTAVDKVLTEGKVLTPDLGGKSGTNEITDAVLAN 359
Query: 368 L 368
+
Sbjct: 360 I 360
>At5g03290 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 372
Score = 222 bits (565), Expect = 8e-58
Identities = 138/360 (38%), Positives = 201/360 (55%), Gaps = 23/360 (6%)
Query: 12 RAYASNAKNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGK 71
RA+ S+ +T L PGDGIG E+ + KK+ + G+ ++ + G E T
Sbjct: 33 RAFCSSTTPITATLFPGDGIGPEIAESVKKVFTTA----GVPIEWEEHYVGTEIDPRTQS 88
Query: 72 ALPDETIDILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKD 131
L E+++ ++ G L G + +P K G+ S + LRK L L+ANVRP S+ G K
Sbjct: 89 FLTWESLESVRRNKVG-LKGPMATPIGK--GHRSLNLTLRKELNLYANVRPCYSLPGYKT 145
Query: 132 R--KVDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQR 189
R VDL+ +RENTE Y LE + V ++ K IT A+ +A A A+
Sbjct: 146 RYDDVDLITIRENTEGEYSGLEHQVV-----RGVVESLKIITRQASLRVAEYAFLYAKT- 199
Query: 190 LEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFRE 249
+G ++ HK+N++ ++DGLF + CRE E KY + Y E ++D+ + +
Sbjct: 200 ---HGRERVSAIHKANIMQKTDGLFLKCCREVAE----KYPEITYEEVVIDNCCMMLVKN 252
Query: 250 PECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPN-IVIGEPCHGSAPDIAGKGIS 308
P FDV+V PNLYGDI+SD A LVG LG+ PS N+G + + + E HGSAPDIAGK ++
Sbjct: 253 PALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSCNIGEDGVALAEAVHGSAPDIAGKNLA 312
Query: 309 NPIATIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSKL 368
NP A + S +ML L + E A+ IH A+ I EGKY T DLGG+STT + + + L
Sbjct: 313 NPTALLLSGVMMLRHLKFNEQAEQIHSAIINTIAEGKYRTADLGGSSTTTEFTKAICDHL 372
>7293593 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 377
Score = 216 bits (550), Expect = 4e-56
Identities = 142/366 (38%), Positives = 199/366 (53%), Gaps = 38/366 (10%)
Query: 12 RAYASNAKNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNT-- 69
R+Y+S K +T LIPGDGIG E+ A +KI + N + WE T
Sbjct: 41 RSYSSGTKKVT--LIPGDGIGPEISAAVQKIFTAAN-----------VPIEWEAVDVTPV 87
Query: 70 ----GK-ALPDETIDILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVK 124
GK +P ID + G L G + +P K G+ S +ALRK L+ANVRP +
Sbjct: 88 RGPDGKFGIPQAAIDSVNTNKIG-LKGPLMTPVGK--GHRSLNLALRKEFNLYANVRPCR 144
Query: 125 SVDGTKDR--KVDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIA 182
S++G K VD+V +RENTE Y +E +D V + K ITE A+K +A A
Sbjct: 145 SLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDG-----VVQSIKLITEEASKRVAEYA 199
Query: 183 LQIAQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSM 242
Q A+ N +TV HK+N++ SDGLF R+ + K+ +Q+ E+ +D++
Sbjct: 200 FQYAKN----NNRKKVTVVHKANIMRMSDGLFLRCVRDMAQ----KFPEIQFEEKYLDTV 251
Query: 243 VYRMFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPCHGSAPDI 302
M + P +DV+V PNLYGDILSD A LVG LG+ PS N+G N + E HG+APDI
Sbjct: 252 CLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDI 311
Query: 303 AGKGISNPIATIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLE 362
AGK ++NP A + S +ML + A I +A I+EGKYLT DLGG + +
Sbjct: 312 AGKDLANPTALLLSAVMMLRHMELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTN 371
Query: 363 DVLSKL 368
++ +KL
Sbjct: 372 EICAKL 377
>Hs5031777 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 366
Score = 211 bits (538), Expect = 1e-54
Identities = 136/351 (38%), Positives = 195/351 (54%), Gaps = 25/351 (7%)
Query: 22 TIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGK-ALPDETIDI 80
T+ LIPGDGIG E+ A KI ++ + + G GK +P E +
Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQG-----PGGKWMIPSEAKES 87
Query: 81 LKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKD--RKVDLVI 138
+ G L G +++P G+ S + LRK L+ANVRP S++G K V++V
Sbjct: 88 MDKNKMG-LKGPLKTPIAA--GHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVT 144
Query: 139 VRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHATL 198
+RENTE Y +E +D V + K ITE A+K IA A + A+ N + +
Sbjct: 145 IRENTEGEYSGIEHVIVDG-----VVQSIKLITEGASKRIAEFAFEYARN----NHRSNV 195
Query: 199 TVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFDVVVA 258
T HK+N++ SDGLF + CRE E+ KD +++NE +D++ M ++P FDV+V
Sbjct: 196 TAVHKANIMRMSDGLFLQKCREVAESCKD----IKFNEMYLDTVCLNMVQDPSQFDVLVM 251
Query: 259 PNLYGDILSDGAAALVGSLGVVPSANVGPN-IVIGEPCHGSAPDIAGKGISNPIATIRST 317
PNLYGDILSD A L+G LGV PS N+G N + I E HG+APDIAGK ++NP A + S
Sbjct: 252 PNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSA 311
Query: 318 ALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSKL 368
+ML +G + A I A A I++GK LT DLGGN+ E++ ++
Sbjct: 312 VMMLRHMGLFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362
>At3g09805 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 374
Score = 206 bits (525), Expect = 3e-53
Identities = 137/367 (37%), Positives = 198/367 (53%), Gaps = 26/367 (7%)
Query: 6 FIQLSRRAYASNAKNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWET 65
FI +SR A+ S++ + L PGDGIG E+ + K++ + + +F+ G E
Sbjct: 30 FISVSR-AFFSSSTPIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFV----GTEV 84
Query: 66 FQNTGKALP-DETIDILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVK 124
T L D +LKN+ L G + +P K G+ S + LRK L L+ANVRP
Sbjct: 85 DPRTNSFLTWDNLQSVLKNKV--GLKGPMATPIGK--GHRSLNLTLRKELNLYANVRPCY 140
Query: 125 SVDGTKDR--KVDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIA 182
S+ G K R VDL+ +RENTE Y LE + V ++ K IT A+ +A A
Sbjct: 141 SLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKG-----VVESLKIITRKASMRVAEYA 195
Query: 183 LQIAQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSM 242
A+ +G ++ HK+N++ ++DGLF + C E KY + Y + ++D+
Sbjct: 196 FLYAKT----HGRKKVSAIHKANIMQKTDGLFLQCCDEVAA----KYPEIYYEKVVIDNC 247
Query: 243 VYRMFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPN-IVIGEPCHGSAPD 301
+ + P FDV+V PNLYGDI+SD A LVG LG+ PS N+G + I + E HGSAPD
Sbjct: 248 CMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPD 307
Query: 302 IAGKGISNPIATIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVL 361
IAG ++NP A + S +ML L + A+ IH A+ I EGKY T DLGG+STT
Sbjct: 308 IAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADLGGSSTTTDFT 367
Query: 362 EDVLSKL 368
+ + L
Sbjct: 368 KAICDHL 374
>CE10354 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 374
Score = 202 bits (514), Expect = 6e-52
Identities = 132/371 (35%), Positives = 195/371 (51%), Gaps = 52/371 (14%)
Query: 23 IGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNT---GK----ALPD 75
+ LIPGDGIG E+ + +KI E+ D W+ T G+ +P
Sbjct: 27 VTLIPGDGIGPEISASVQKIFEAA-----------DAPIAWDPVDVTPVKGRDGVFRIPS 75
Query: 76 ETIDILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDR--K 133
I+++ G L G +++P K G+ S +A+RK L+ANVRP +S++G K
Sbjct: 76 RCIELMHANKVG-LKGPLETPIGK--GHRSLNLAVRKEFSLYANVRPCRSLEGHKTLYDN 132
Query: 134 VDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQN 193
VD+V +RENTE Y +E + V + K ITE A++N+A+ A + A+Q N
Sbjct: 133 VDVVTIRENTEGEYSGIEHEIVPG-----VVQSIKLITETASRNVASFAFEYARQ----N 183
Query: 194 GHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECF 253
G +T HK+N++ QSDGLF +CRE Y +++ E +D++ M ++P +
Sbjct: 184 GRKVVTAVHKANIMRQSDGLFLSICREQAAL----YPDIKFKEAYLDTVCLNMVQDPSQY 239
Query: 254 DVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGE----------------PCHG 297
DV+V PNLYGDILSD A LVG LGV PS N+G + + HG
Sbjct: 240 DVLVMPNLYGDILSDLCAGLVGGLGVTPSGNIGKGAAVFDEIQFFIQTKLTKFLYRSVHG 299
Query: 298 SAPDIAGKGISNPIATIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTT 357
+APDIAG+ +NP A + S +ML ++ P+ A I KAV I +G+ T DLGG T
Sbjct: 300 TAPDIAGQDKANPTALLLSAVMMLRYMNLPQHAARIEKAVFDAIADGRAKTGDLGGTGTC 359
Query: 358 QQVLEDVLSKL 368
DV +++
Sbjct: 360 SSFTADVCARV 370
>SPAC11G7.03 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 356
Score = 187 bits (474), Expect = 3e-47
Identities = 133/351 (37%), Positives = 192/351 (53%), Gaps = 21/351 (5%)
Query: 22 TIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETIDIL 81
T+ LIPGDGIG+E A +I ++ N + F+ ID+ + +++G AL E I L
Sbjct: 22 TVTLIPGDGIGRETSNAVTEIFKTANVP--IEFEEIDVTGMEKNNKSSGDAL-HEAIQSL 78
Query: 82 KNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDR--KVDLVIV 139
K G L G + +P K G++S VALRK L ++A++ +K++ G K R VD I+
Sbjct: 79 KRNKVG-LKGILFTPFEK-GGHTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAII 136
Query: 140 RENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHATLT 199
RENTE Y LE + V ++ K ITE +K IA A A Q NG ++T
Sbjct: 137 RENTEGEYSGLEHQSVPG-----VVESLKIITEYKSKRIAQFAFDFALQ----NGRKSVT 187
Query: 200 VTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFDVVVAP 259
HK+N++ +DGLFR T+ + Y + + IVD+ + P+ FDV+V P
Sbjct: 188 CIHKANIMKLADGLFRR----TFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMP 243
Query: 260 NLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEP-CHGSAPDIAGKGISNPIATIRSTA 318
NLYG ILS+ +ALVG GV+P AN G + + EP C I G+G +NP A I S
Sbjct: 244 NLYGSILSNIGSALVGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSAC 303
Query: 319 LMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSKLD 369
LML LG + A I+ A + I EGK LT DLGG+++T +L +++
Sbjct: 304 LMLRHLGLKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERME 354
>SPBC902.05c [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 378
Score = 184 bits (468), Expect = 1e-46
Identities = 122/354 (34%), Positives = 193/354 (54%), Gaps = 26/354 (7%)
Query: 20 NLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETID 79
N T+ +I GDGIG E+ + ++I ++ K + ++ + + + +N +PD+ +
Sbjct: 45 NYTVTMIAGDGIGPEIAQSVERIFKAA--KVPIEWERVKV---YPILKNGTTTIPDDAKE 99
Query: 80 ILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDR--KVDLV 137
++ + AL G + +P K G+ S + LR+ GLFANVRP S+ G K V+ V
Sbjct: 100 SVRKN-KVALKGPLATPIGK--GHVSMNLTLRRTFGLFANVRPCVSITGYKTPYDNVNTV 156
Query: 138 IVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHAT 197
++RENTE Y +E I V + K IT A++ + A Q A+Q G
Sbjct: 157 LIRENTEGEYSGIEHEVIPG-----VVQSIKLITRAASERVIRYAFQYARQ----TGKNN 207
Query: 198 LTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFD--V 255
+TV HK+ ++ +DGLF E +E +Y ++ E+I+D+ ++ +P ++ V
Sbjct: 208 ITVVHKATIMRMADGLFLECAKEL----APEYPDIELREEILDNACLKIVTDPVPYNNTV 263
Query: 256 VVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPCHGSAPDIAGKGISNPIATIR 315
+V PNLYGDI+SD A L+G LG+ PS N+G I E HG+APDIAGKG++NP A +
Sbjct: 264 MVMPNLYGDIVSDMCAGLIGGLGLTPSGNIGNQASIFEAVHGTAPDIAGKGLANPTALLL 323
Query: 316 STALMLEFLGYPEPAKDIHKAV-DANIREGKYLTPDLGGNSTTQQVLEDVLSKL 368
S+ +ML+ + + AK I A+ D T DLGG S Q + ++SKL
Sbjct: 324 SSVMMLKHMNLNDYAKRIESAIFDTLANNPDARTKDLGGKSNNVQYTDAIISKL 377
>At4g35650 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 368
Score = 184 bits (468), Expect = 1e-46
Identities = 126/355 (35%), Positives = 195/355 (54%), Gaps = 33/355 (9%)
Query: 22 TIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETIDIL 81
T+ LIPGDGIG V A ++++E+++ +E N K +P+E I+ +
Sbjct: 40 TVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFE--------RYEVLGNMRK-VPEEVIESV 90
Query: 82 KNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDG--TKDRKVDLVIV 139
K + L G + +P G SS + LRK L +FA++ +V G T+ VD+V++
Sbjct: 91 KRN-KVCLKGGLATPVGG--GVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVI 147
Query: 140 RENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHATLT 199
RENTE Y LE + V ++ K IT+ ++ IA A + A N +T
Sbjct: 148 RENTEGEYSGLEHEVVPG-----VVESLKVITKFCSERIARYAFEYAYL----NNRKKVT 198
Query: 200 VTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFDVVVAP 259
HK+N++ +DGLF E CRE + Y G+ YNE IVD+ ++ +PE FDV+V P
Sbjct: 199 AVHKANIMKLADGLFLESCREVAK----HYSGITYNEIIVDNCCMQLVAKPEQFDVMVTP 254
Query: 260 NLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPCHGSAPDIAGKGI-----SNPIATI 314
NLYG+++++ AA + G GV+P NVG I E SA ++ + +NP+A +
Sbjct: 255 NLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQ-GASAGNVGNDKMVEQKKANPVALL 313
Query: 315 RSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSKLD 369
S+A+ML L +P A + AV I+EGKY T DLGG+ TTQ+V++ V++ L+
Sbjct: 314 LSSAMMLRHLRFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE 368
>At4g35260 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 367
Score = 183 bits (465), Expect = 3e-46
Identities = 127/355 (35%), Positives = 194/355 (53%), Gaps = 35/355 (9%)
Query: 23 IGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETIDILK 82
+ LIPGDGIG V A ++++E+++ + F+ D+ + P+ I K
Sbjct: 40 VTLIPGDGIGPLVTNAVEQVMEAMHAP--IFFEKYDVHG------EMSRVPPEVMESIRK 91
Query: 83 NQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDG--TKDRKVDLVIVR 140
N+ L G +++P G SS V LRK L LFA++ ++ G T+ VD+V++R
Sbjct: 92 NKV--CLKGGLKTPVGG--GVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIR 147
Query: 141 ENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHATLTV 200
ENTE Y LE + V ++ K IT+ ++ IA A + A N +T
Sbjct: 148 ENTEGEYAGLEHEVVPG-----VVESLKVITKFCSERIAKYAFEYAYL----NNRKKVTA 198
Query: 201 THKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFDVVVAPN 260
HK+N++ +DGLF E CRE + KY + YNE IVD+ ++ +PE FDV+V PN
Sbjct: 199 VHKANIMKLADGLFLESCREVAK----KYPSITYNEIIVDNCCMQLVAKPEQFDVMVTPN 254
Query: 261 LYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPCHGSAPDIAGK------GISNPIATI 314
LYG+++++ AA + G GV+P NVG + + E G++ GK +NP+A +
Sbjct: 255 LYGNLVANTAAGIAGGTGVMPGGNVGADHAVFE--QGASAGNVGKDKIVLENKANPVALL 312
Query: 315 RSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSKLD 369
S+A+ML L +P A + AV I EGK T DLGG STTQ+V++ V++KLD
Sbjct: 313 LSSAMMLRHLQFPSFADRLETAVKKVIAEGKCRTKDLGGTSTTQEVVDAVIAKLD 367
>At2g17130 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 367
Score = 183 bits (464), Expect = 4e-46
Identities = 128/364 (35%), Positives = 197/364 (53%), Gaps = 41/364 (11%)
Query: 17 NAKNLTIGLIPGDGIGKEVIPAGKKILESLN-PKYGLSFKFIDLQAGWETFQNTG--KAL 73
+ K + LIPGDG+G V A ++++E+++ P Y +E F+ G K+L
Sbjct: 34 DGKPRPVTLIPGDGVGPLVTNAVQQVMEAMHAPVY------------FEPFEVHGDMKSL 81
Query: 74 PDETIDILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDR- 132
P+ ++ +K + L G +++P G SS V LRK L LFA++ ++ G R
Sbjct: 82 PEGLLESIKKN-KVCLKGGLKTPVGG--GVSSLNVNLRKELDLFASLVNCFNLPGLASRH 138
Query: 133 -KVDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLE 191
VD+V++RENTE Y LE + V ++ K IT+ ++ IA A + A
Sbjct: 139 ENVDIVVIRENTEGEYAGLEHEVVPG-----VVESLKVITKFCSERIAKYAFEYAYL--- 190
Query: 192 QNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPE 251
N +T HK+N++ +DGLF E C+E + KY + YNE IVD+ ++ PE
Sbjct: 191 -NNRKKVTAVHKANIMKLADGLFLESCQEVAK----KYPSIAYNEIIVDNCCMQLVARPE 245
Query: 252 CFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPCHGSAPDIAGKGI---- 307
FDV+V PNLYG+++++ AA + G GV+P NVG + E G++ GK
Sbjct: 246 QFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGAEYAVFE--QGASAGNVGKDTTEEQ 303
Query: 308 --SNPIATIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVL 365
+NP+A + S+A+ML L +P A + AV I EG T DLGGNSTTQ+V++ V+
Sbjct: 304 KNANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGNCRTEDLGGNSTTQEVVDAVI 363
Query: 366 SKLD 369
+ LD
Sbjct: 364 ANLD 367
>YNL037c [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 360
Score = 179 bits (453), Expect = 8e-45
Identities = 126/355 (35%), Positives = 186/355 (51%), Gaps = 35/355 (9%)
Query: 22 TIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETF---QNTGKALPDETI 78
T+ LIPGDG+GKE+ + + I E+ N + WET Q K E +
Sbjct: 30 TVTLIPGDGVGKEITDSVRTIFEAEN-----------IPIDWETINIKQTDHKEGVYEAV 78
Query: 79 DILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDR--KVDL 136
+ LK G L G +P + G+ S VALRK L ++ANV KS+ G K R +DL
Sbjct: 79 ESLKRNKIG-LKGLWHTPADQT-GHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDL 136
Query: 137 VIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHA 196
+++RENTE + LE + V ++ K +T T+ IA A A++
Sbjct: 137 IVIRENTEGEFSGLEHESVPG-----VVESLKVMTRPKTERIARFAFDFAKKY----NRK 187
Query: 197 TLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFDVV 256
++T HK+N++ DGLFR + E + +Y + + IVD+ + +P FDV+
Sbjct: 188 SVTAVHKANIMKLGDGLFRNIITEI---GQKEYPDIDVSSIIVDNASMQAVAKPHQFDVL 244
Query: 257 VAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPCHGSAP---DIAGKGISNPIAT 313
V P++YG IL + AAL+G G+V AN G + + EP GS DI G+ ++NP A
Sbjct: 245 VTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEP--GSRHVGLDIKGQNVANPTAM 302
Query: 314 IRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSKL 368
I S+ LML LG E A I KAV I EGK+ T D+GG+S+T ++++KL
Sbjct: 303 ILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357
>YOR136w [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 369
Score = 178 bits (452), Expect = 1e-44
Identities = 132/354 (37%), Positives = 185/354 (51%), Gaps = 29/354 (8%)
Query: 22 TIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETID-I 80
T+ I GDGIG E+ + KKI + N + ++ D+ F N +PD + I
Sbjct: 38 TVSFIEGDGIGPEISKSVKKIFSAANVP--IEWESCDVSP---IFVNGLTTIPDPAVQSI 92
Query: 81 LKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKD--RKVDLVI 138
KN AL G + +P K G+ S + LRK GLFANVRP KS++G K VDLV+
Sbjct: 93 TKNLV--ALKGPLATPIGK--GHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVL 148
Query: 139 VRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHATL 198
+RENTE Y S I+ V + K IT A++ + A + A+ G +
Sbjct: 149 IRENTEGEY-----SGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAI----GRPRV 199
Query: 199 TVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFD--VV 256
V HKS + +DGLF V +E + +Y + +++D+ V ++ P + V
Sbjct: 200 IVVHKSTIQRLADGLFVNVAKELSK----EYPDLTLETELIDNSVLKVVTNPSAYTDAVS 255
Query: 257 VAPNLYGDILSDGAAAL-VGSLGVVPSANVGPNIVIGEPCHGSAPDIAGKGISNPIATIR 315
V PNLYGDILSD + L GSLG+ PSAN+G I I E HGSAPDIAG+ +NP A +
Sbjct: 256 VCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLL 315
Query: 316 STALMLEFLGYPEPAKDIHKAVDANIREG-KYLTPDLGGNSTTQQVLEDVLSKL 368
S+ +ML +G A I AV + I G + T DL G +TT E V+ +L
Sbjct: 316 SSVMMLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL 369
>At5g14200 [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 409
Score = 166 bits (420), Expect = 5e-41
Identities = 127/378 (33%), Positives = 193/378 (50%), Gaps = 33/378 (8%)
Query: 13 AYASNAKNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKA 72
A + K I L+PGDGIG EVI K +L+ GL F F ++ G G
Sbjct: 39 AASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAALDLVGVP 98
Query: 73 LPDETIDILKNQCEGALFGAVQS-PTTKVEGYSSPIVAL---RKNLGLFANVRPV----K 124
LP+ET K + L GA+ K E + P +AL R++L +FAN+RP +
Sbjct: 99 LPEETFTAAKLS-DAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQ 157
Query: 125 SVDGTKDRK-----VDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIA 179
VD + +K VD++IVRE T +Y + G V +T+ IA
Sbjct: 158 LVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIA 217
Query: 180 TIALQIAQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIV 239
+A + A++R L K+NVL S + R+ A +Y V+ + V
Sbjct: 218 RVAFETARKR-----RGKLCSVDKANVLDASI-----LWRKRVTALASEYPDVELSHMYV 267
Query: 240 DSMVYRMFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPN-IVIGEPCHGS 298
D+ ++ R+P+ FD +V N++GDILSD A+ + GS+G++PSA++G + + EP HGS
Sbjct: 268 DNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGS 327
Query: 299 APDIAGKGISNPIATIRSTALMLEF-LGYPEPAKDIHKAV----DANIREGKYLTPD--- 350
APDIAG+ +NP+ATI S A++L++ LG + AK I AV + R G +P
Sbjct: 328 APDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKL 387
Query: 351 LGGNSTTQQVLEDVLSKL 368
+G ++VL+ V SK+
Sbjct: 388 VGCKEMGEEVLKSVESKV 405
>Hs4758582 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 393
Score = 166 bits (419), Expect = 7e-41
Identities = 112/347 (32%), Positives = 175/347 (50%), Gaps = 25/347 (7%)
Query: 22 TIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETIDIL 81
T+ +IPGDGIG E++ K + + A E +N A+ +
Sbjct: 56 TVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRNAIMAIRRNRV--- 112
Query: 82 KNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDG--TKDRKVDLVIV 139
AL G +++ + S LR +L L+ANV KS+ G T+ + +D++IV
Sbjct: 113 ------ALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIV 166
Query: 140 RENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHATLT 199
RENTE Y LE + V ++ K IT+ + IA A ++AQ+ +G +T
Sbjct: 167 RENTEGEYSSLEHESV-----AGVVESLKIITKAKSLRIAEYAFKLAQE----SGRKKVT 217
Query: 200 VTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFDVVVAP 259
HK+N++ DGLF + CRE +Y + + IVD+ ++ P+ FDV+V P
Sbjct: 218 AVHKANIMKLGDGLFLQCCREVAA----RYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 273
Query: 260 NLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPC-HGSAPDIAGKGISNPIATIRSTA 318
NLYG+I+++ A LVG G+V AN G + E + IA K I+NP AT+ ++
Sbjct: 274 NLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASC 333
Query: 319 LMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVL 365
+ML+ L A I KAV A++ TPD+GG TT + ++DV+
Sbjct: 334 MMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVI 380
>CE08620 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 379
Score = 163 bits (412), Expect = 4e-40
Identities = 120/355 (33%), Positives = 179/355 (49%), Gaps = 25/355 (7%)
Query: 19 KNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETI 78
+ L + +IPGDG+G E+I + I++ G+ +F ++ E ++ +
Sbjct: 41 QKLKVTIIPGDGVGPELIYTVQDIVKQT----GIPIEFEEIFLS-EVHYTRSSSIENAVE 95
Query: 79 DILKNQCEGALFGAVQ-SPTTKVEGYSSPI-VALRKNLGLFANVRPVKSVDGTKDR---K 133
I +N AL GA++ S EG + + LR++L LFANV +K++DG K R +
Sbjct: 96 SIGRNN-NVALKGAIEESAVLHTEGELQGLNMRLRRSLDLFANVVHIKTLDGIKTRHGKQ 154
Query: 134 VDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQN 193
+D VIVRE TE Y LE + V + K T + IA A A +
Sbjct: 155 LDFVIVREQTEGEYSSLEHELVPG-----VIECLKISTRTKAERIAKFAFDYATK----T 205
Query: 194 GHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECF 253
G +T HK+N++ DGLF C E +Y +Q+ I+D+ ++ +PE F
Sbjct: 206 GRKKVTAVHKANIMKLGDGLFLRTC----EGVAKQYPKIQFESMIIDNTCMQLVSKPEQF 261
Query: 254 DVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEP-CHGSAPDIAGKGISNPIA 312
DV+V PNLYG+I+ + AA LVG GVVP +VG + VI EP S + G+ I+NP A
Sbjct: 262 DVMVMPNLYGNIIDNLAAGLVGGAGVVPGQSVGRDFVIFEPGSRHSFQEAMGRSIANPTA 321
Query: 313 TIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSK 367
I A ML L + +AV ++EGK T DLGG +TT + V+ K
Sbjct: 322 MILCAANMLNHLHLDAWGNSLRQAVADVVKEGKVRTRDLGGYATTVDFADAVIDK 376
>At1g31180 [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 404
Score = 162 bits (411), Expect = 6e-40
Identities = 125/372 (33%), Positives = 191/372 (50%), Gaps = 33/372 (8%)
Query: 19 KNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETI 78
K I L+PGDGIG EVI K +L+ GL F F ++ G G LP+ET
Sbjct: 42 KRYNITLLPGDGIGPEVISVAKNVLQKAGFLQGLEFDFQEMPFGGAALDLVGVPLPEETS 101
Query: 79 DILKNQCEGALFGAVQS-PTTKVEGYSSP---IVALRKNLGLFANVRPV----KSVDGTK 130
K Q + L GA+ K E + P ++ +R++L +FAN+RP + VD +
Sbjct: 102 TAAK-QSDAILLGAIGGYKWDKNEKHLRPEMGLLNIRRDLNVFANLRPATVLPQLVDAST 160
Query: 131 DRK-----VDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQI 185
+K VD++IVRE T +Y + G V T+ IA +A +
Sbjct: 161 LKKEVAQGVDMMIVRELTGGIYFGEPRGITINENGEEVGFNTEIYAAHEIDRIARVAFET 220
Query: 186 AQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYR 245
A++R L K+NVL S + R+ A +Y V+ + VD+ +
Sbjct: 221 ARKR-----RGKLCSVDKANVLDASI-----LWRKRVTALASEYPDVELSHMYVDNAAMQ 270
Query: 246 MFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPN-IVIGEPCHGSAPDIAG 304
+ R+P+ FD +V N++GDILSD A+ + GS+G++PSA++G + + EP HGSAPDIAG
Sbjct: 271 LVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAG 330
Query: 305 KGISNPIATIRSTALMLEF-LGYPEPAKDIHKAV----DANIREGKYLTPD---LGGNST 356
+ +NP+ATI S A++L++ LG + AK I AV + R G +P +G
Sbjct: 331 QDKANPLATILSAAMLLKYGLGEEKAAKMIEDAVVDALNKGFRTGDIYSPGNKLVGCKEM 390
Query: 357 TQQVLEDVLSKL 368
++VL+ V SK+
Sbjct: 391 GEEVLKSVDSKV 402
>At1g80560 [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 405
Score = 160 bits (406), Expect = 2e-39
Identities = 122/372 (32%), Positives = 190/372 (50%), Gaps = 35/372 (9%)
Query: 19 KNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETI 78
K TI L+PGDGIG EV+ K +L+ G+ F F ++ G G LP+ETI
Sbjct: 41 KRYTITLLPGDGIGPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPEETI 100
Query: 79 DILKNQCEGALFGAVQS-PTTKVEGYSSP---IVALRKNLGLFANVRPV----KSVDGTK 130
K + + L GA+ E + P ++ +R L +FAN+RP + VD +
Sbjct: 101 SAAK-ESDAVLLGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDAST 159
Query: 131 DRK-----VDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQI 185
++ VDL++VRE T +Y + G V T+ IA +A +
Sbjct: 160 LKREVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFET 219
Query: 186 AQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYR 245
A++R L K+NVL S + R+ A +Y V+ + VD+ +
Sbjct: 220 ARKR-----RGKLCSVDKANVLEASI-----LWRKRVTALASEYPDVELSHMYVDNAAMQ 269
Query: 246 MFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANV---GPNIVIGEPCHGSAPDI 302
+ R+P+ FD +V N++GDILSD A+ + GS+G++PSA++ GP + EP HGSAPDI
Sbjct: 270 LVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLF--EPIHGSAPDI 327
Query: 303 AGKGISNPIATIRSTALMLEF-LGYPEPAKDIHKAVDANIREGKYLTPDLGGNST----T 357
AG+ +NP+ATI S A++L++ LG + AK I AV + G + T D+ T
Sbjct: 328 AGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNG-FRTGDIYSAGTKLVGC 386
Query: 358 QQVLEDVLSKLD 369
+++ E+VL +D
Sbjct: 387 KEMGEEVLKSVD 398
>Hs5901982 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 385
Score = 150 bits (380), Expect = 2e-36
Identities = 109/349 (31%), Positives = 171/349 (48%), Gaps = 22/349 (6%)
Query: 23 IGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETIDILK 82
+ ++PGDG+G E++ A K++ ++ + +F + QN E +
Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAA----AVPVEFQEHHLS--EVQNMASEEKLEQVLSSM 104
Query: 83 NQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDG--TKDRKVDLVIVR 140
+ + A+ G + +P +S + LR+ L LFANV VKS+ G T+ +DLVI+R
Sbjct: 105 KENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIR 164
Query: 141 ENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHATLTV 200
E TE Y LE + A G V + K +T ++ IA A A ++ G +T
Sbjct: 165 EQTEGEYSSLEH---ESARG--VIECLKIVTRAKSQRIAKFAFDYATKK----GRGKVTA 215
Query: 201 THKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFDVVVAPN 260
HK+N++ DGLF + C E E Y +++ I+D+ ++ + P FDV+V PN
Sbjct: 216 VHKANIMKLGDGLFLQCCEEVAEL----YPKIKFETMIIDNCCMQLVQNPYQFDVLVMPN 271
Query: 261 LYGDILSDGAAALVGSLGVVPSANVGPNIVIGEP-CHGSAPDIAGKGISNPIATIRSTAL 319
LYG+I+ + AA LVG GVVP + + E G+ I+NP A + S +
Sbjct: 272 LYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASN 331
Query: 320 MLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSKL 368
ML L + I AV I+ GK T D+GG STT ++ V+ L
Sbjct: 332 MLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>7300799 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 370
Score = 149 bits (377), Expect = 5e-36
Identities = 108/352 (30%), Positives = 166/352 (46%), Gaps = 24/352 (6%)
Query: 18 AKNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDET 77
A T LIPGDG+G E++ + +++ ++ + F+ E L D
Sbjct: 35 ANRTTCTLIPGDGVGPELVYSLQEVFKAASVPVDFECYFLS-----EINPVLSAKLEDVV 89
Query: 78 IDILKNQCEGALFGAVQSPT-TKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDR--KV 134
I KN+ + G + +P + V + + LR +L L+ANV V+S+ G K R +
Sbjct: 90 ASIQKNKV--CIKGVLATPDYSNVGDLQTLNMKLRNDLDLYANVVHVRSLPGVKTRHTNI 147
Query: 135 DLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNG 194
D VI+RE TE Y LE + + + K IT + IA A A + N
Sbjct: 148 DTVIIREQTEGEYSALEHESVPG-----IVECLKIITAKKSMRIAKFAFDYATK----NQ 198
Query: 195 HATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFD 254
+T HK+N++ DGLF C E Y +Q+ + IVD+ +M P FD
Sbjct: 199 RKKVTAVHKANIMKLGDGLFLRSCEEVSRL----YPRIQFEKMIVDNTTMQMVSNPNQFD 254
Query: 255 VVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEP-CHGSAPDIAGKGISNPIAT 313
V+V PNLYG I+ + A+ LVG GVV A+ V+ EP + + GK ++NP A
Sbjct: 255 VMVTPNLYGAIVDNLASGLVGGAGVVAGASYSSESVVFEPGARHTFAEAVGKNVANPTAM 314
Query: 314 IRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVL 365
+ +L + P + I A++ + +GK T DLGG STTQ ++
Sbjct: 315 LLCGVKLLRHINLPTYGEIIQNAINKVLNDGKVRTKDLGGQSTTQDFTRAII 366
>7301367 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 393
Score = 144 bits (362), Expect = 3e-34
Identities = 105/349 (30%), Positives = 173/349 (49%), Gaps = 25/349 (7%)
Query: 23 IGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQNTGKALPDETIDILK 82
+ ++PG GIG E++ ++I + F+ ID+ E + A+ I +
Sbjct: 60 VTMLPGGGIGPELMGYVREIFRYCGAP--IDFEVIDIDPSTEGNDDLDYAITS----IKR 113
Query: 83 NQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDRK--VDLVIVR 140
N AL G +++ + + S VA+R L L+ NV KS G R +D+V++R
Sbjct: 114 NGV--ALKGNIETKSQSLTEVSRN-VAIRNELDLYVNVVHCKSYPGIPARHHDIDVVLIR 170
Query: 141 ENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHATLTV 200
+NT+ Y LE + + ++ K +T + +A A + A+Q N +T
Sbjct: 171 QNTDGEYAMLEHESVPG-----IVESMKVVTVENAERVARYAFEFARQ----NNRKKVTT 221
Query: 201 THKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPECFDVVVAPN 260
HK+N++ SDGLF EV ++ Y +++N I+D+ + P FDV+ N
Sbjct: 222 IHKANIMKLSDGLFLEVANRVHK----DYPELEHNNMIIDNTCMQSVSNPHQFDVMNMTN 277
Query: 261 LYGDILSDGAAALVGSLGVVPSANVGPNIVIGEP-CHGSAPDIAGKGISNPIATIRSTAL 319
LYG I+S+ L+G G++ N G + I EP + IAGK I+NP+A I ++
Sbjct: 278 LYGTIVSNVLCGLMGGAGLISGRNYGDHYAIFEPGTRNTGTAIAGKNIANPVAMISASID 337
Query: 320 MLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDVLSKL 368
ML LG+ E A I +AV I TPD+GG +++ V+E++L L
Sbjct: 338 MLNHLGHKEHANVIQEAVYQTIVNDAIRTPDIGGTNSSTDVVENILKIL 386
>CE16887 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 373
Score = 143 bits (360), Expect = 5e-34
Identities = 112/372 (30%), Positives = 181/372 (48%), Gaps = 30/372 (8%)
Query: 2 MRTRFIQLSRRAYASNAKNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQA 61
+RT I R A T+ +PGDGIG E+I + I F F
Sbjct: 17 IRTHQIPGHRLPLAKYGGRHTVCALPGDGIGPEMIAHIRNI-----------FSFCHAPV 65
Query: 62 GWETFQNTGKALP-DETIDILKNQCEG-ALFGAVQSPTTKVEGYSSPIVALRKNLGLFAN 119
+E Q + L D +L + G A+ G +++ + ++S V LR L L+AN
Sbjct: 66 NFEEVQVSSSLLDGDMDAAMLAIERNGVAIKGNIETKHDDPQ-FNSRNVELRTKLDLYAN 124
Query: 120 VRPVKSVDG--TKDRKVDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKN 177
+ ++ T+ +D+V++RENTE Y LE + + ++ K +T +
Sbjct: 125 ILHCVTIPTVPTRHSGIDIVLIRENTEGEYSGLEHEAVPG-----IVESIKIVTREKIER 179
Query: 178 IATIALQIAQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQ 237
I+ +A + A+ NG +T HK+N+ DGLF +V R+ E KD +++
Sbjct: 180 ISRMAFEYAKA----NGRKKVTAVHKANIQKLGDGLFLKVVRDMSEDYKD----IKFEAM 231
Query: 238 IVDSMVYRMFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEP-CH 296
IVD+ ++ +P+ FDV+V PNLYG+I+S+ A LVG G+V N+G + E
Sbjct: 232 IVDNASMQLVSKPQQFDVMVMPNLYGNIISNIACGLVGGPGLVSGMNLGDKYAVFETGTR 291
Query: 297 GSAPDIAGKGISNPIATIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNST 356
+ +AGK I+NP A IR++ ML +LG A I A+ + E + T D+GGN++
Sbjct: 292 NTGTSLAGKDIANPTAFIRASVDMLRYLGCHYHANIISDALWKALVEQRIHTADIGGNNS 351
Query: 357 TQQVLEDVLSKL 368
V+ L +
Sbjct: 352 ASDVINATLQNI 363
>CE00970 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 380
Score = 142 bits (359), Expect = 6e-34
Identities = 104/356 (29%), Positives = 182/356 (50%), Gaps = 20/356 (5%)
Query: 3 RTRFIQLSRRAYASNAKNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAG 62
R+ +Q + A + ++PGDGIG E++ ++IL ++ + F+ ++L +
Sbjct: 34 RSPVLQTNTTKLARYGGRHNVTVLPGDGIGPEMLHHVERILSAVQAP--VDFEVVNLTSK 91
Query: 63 WETFQNTGKALPDETIDILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRP 122
+ ++ +A+ I +N AL G +++ + S + LR+ L L+ANV
Sbjct: 92 EDASEDLAEAITA----IKRNGV--ALKGNIETKFDN-PSFVSRNLELRRQLNLYANVLH 144
Query: 123 VKSVDGTKDRK--VDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIAT 180
++ R +D+VI+RENTE Y E ++ A RV ++ K +T ++ I
Sbjct: 145 CSTIPTVPSRHTGIDMVIIRENTEGEYSGNEHEAVN-APHPRVVESLKVVTREKSEQITR 203
Query: 181 IALQIAQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVD 240
A Q A++ G +T HK+N+ DGLF +V + +A +Y +++N IVD
Sbjct: 204 FAFQFAKKY----GRKKVTAVHKANIQKLGDGLFLKVATDIAKA---EYPDIEFNAMIVD 256
Query: 241 SMVYRMFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEP-CHGSA 299
+ ++ P+ FDV++ PNLYG+I+S+ A LVG G+V N+G + + E +
Sbjct: 257 NASMQLVSRPQQFDVMLMPNLYGNIISNIACGLVGGPGLVSGMNIGEDYAVFETGTRNTG 316
Query: 300 PDIAGKGISNPIATIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNS 355
+AGK ++NP A IR+ ML FLG A I ++ + + + T D+GG S
Sbjct: 317 TTLAGKDLANPTAFIRAAVDMLRFLGLQSHADMISDSLFRTLVDKRIHTADIGGTS 372
>YCL018w [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 364
Score = 139 bits (349), Expect = 9e-33
Identities = 119/371 (32%), Positives = 189/371 (50%), Gaps = 43/371 (11%)
Query: 23 IGLIPGDGIGKEVIPAGKKILESLNP-KYGLSFKFIDLQAGWETFQNTGKALPDETIDIL 81
I ++PGD +G+E+ K+L++++ + + F F + G TG LPDE ++
Sbjct: 7 IVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALEAS 66
Query: 82 KNQCEGALFGAVQSPT--TKVEGYSSPIVALRKNLGLFANVRPVK-SVDGTKD------- 131
K + + L GAV P T ++ +RK L L+AN+RP + D D
Sbjct: 67 K-KADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKPQ 125
Query: 132 --RKVDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQR 189
+ D V+VRE +Y K E G VA +++ T + I +A +A
Sbjct: 126 FAKGTDFVVVRELVGGIYFGKRK----EDDGDGVAWDSEQYTVPEVQRITRMAAFMA--- 178
Query: 190 LEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFRE 249
L+ + K+NVL+ S L+R+ ET K+++ ++ Q++DS + +
Sbjct: 179 LQHEPPLPIWSLDKANVLASSR-LWRKTVEETI---KNEFPTLKVQHQLIDSAAMILVKN 234
Query: 250 PECFD-VVVAPNLYGDILSDGAAALVGSLGVVPSANVG----PNIVIG--EPCHGSAPDI 302
P + +++ N++GDI+SD A+ + GSLG++PSA++ N G EPCHGSAPD+
Sbjct: 235 PTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL 294
Query: 303 AGKGISNPIATIRSTALMLEF-LGYPEPAKDIHKAV----DANIREGKYLTPDLGGNSTT 357
K NPIATI S A+ML+ L PE K I AV DA IR G DLGG+++T
Sbjct: 295 P-KNKVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTG-----DLGGSNST 348
Query: 358 QQVLEDVLSKL 368
+V + V ++
Sbjct: 349 TEVGDAVAEEV 359
>SPBC1A4.02c [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 220
Score = 107 bits (267), Expect = 3e-23
Identities = 74/207 (35%), Positives = 118/207 (56%), Gaps = 22/207 (10%)
Query: 178 IATIALQIAQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQ 237
IA +A +A+ N A +T+ K+NVL+ S L+R+ + + K++Y + Q
Sbjct: 18 IARLAAWLAET---SNPPAPVTLLDKANVLATSR-LWRKTVAKIF---KEEYPHLTLKNQ 70
Query: 238 IVDSMVYRMFREPECFD-VVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNI------- 289
++DS + + P + VV+ NL+GDI+SD A+ + GSLG++PSA++ +
Sbjct: 71 LIDSAAMLLVKSPRTLNGVVLTDNLFGDIISDEASVIPGSLGLLPSASLSGVVGKSEEKV 130
Query: 290 -VIGEPCHGSAPDIAGKGISNPIATIRSTALMLEF-LGYPEPAKDIHKAV-----DANIR 342
+ EP HGSAPDIAGKGI NP+ TI S +L+L + L P+ A+ I AV D +I
Sbjct: 131 HCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPKEAEAIEAAVRKVLDDTSIG 190
Query: 343 EGKYLTPDLGGNSTTQQVLEDVLSKLD 369
T DLGG ++T + + V+ +L+
Sbjct: 191 GRGLYTRDLGGEASTADITKAVVEELE 217
>7291785 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 391
Score = 90.5 bits (223), Expect = 4e-18
Identities = 81/352 (23%), Positives = 151/352 (42%), Gaps = 32/352 (9%)
Query: 16 SNAKNLTIGLIPGDGIGKEVIPAGKKILESLNPKYGLSFKFIDLQAGWETFQN-TGKALP 74
S K + LI G+G+G+E++ A ++++ + + W+ K
Sbjct: 65 SAKKTTKVTLINGEGVGRELMDAVQEVICA-----------VKAPIEWDVHDEFKAKDSD 113
Query: 75 DETIDILKNQCEGALFGAVQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDR-- 132
D + ++LK+ + ++ P +RK FA V ++G
Sbjct: 114 DVSPEVLKSLRANKV--GIKGPVDSRHWQRQ----IRKQFAQFAYVSLCSHIEGLDSPYG 167
Query: 133 KVDLVIVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQ 192
D+VI+R+ E Y S I+ V K T IA A +
Sbjct: 168 DFDVVIIRDQMEGDY-----SGIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVK---- 218
Query: 193 NGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKYGGVQYNEQIVDSMVYRMFREPEC 252
N +TV HK+N++ +DG F E R + + D V + E+ +D+ + ++ +P
Sbjct: 219 NKRKRITVAHKANIMRMTDGNFLEAMRAEADKHVDD---VLFEERYLDTCILKILLKPHK 275
Query: 253 FDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPNIVIGEPCHGSAPDIAGKGISNPIA 312
DV+V+ ++YGD+L A ++G G+ P +V + + + +AGK ++NP
Sbjct: 276 CDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGTVFDCRMKACHALAGKDLANPTG 335
Query: 313 TIRSTALMLEFLGYPEPAKDIHKAVDANIREGKYLTPDLGGNSTTQQVLEDV 364
+ S ALML + + A + A+ ++ TPD+GG + + ++ V
Sbjct: 336 PLLSAALMLRHVKMDKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAV 387
>YDL066w [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 428
Score = 53.5 bits (127), Expect = 5e-07
Identities = 35/106 (33%), Positives = 58/106 (54%), Gaps = 6/106 (5%)
Query: 198 LTVTHKSNVLSQSDGLFREVCRETYEAN-KDKYG--GVQYNEQIVDSMVYRMFREPECFD 254
L ++ K+ +L + DG F+++ +E YEA K K+ G+ Y +++D MV +M + F
Sbjct: 224 LFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF- 282
Query: 255 VVVAPNLYGDILSDGAAALVGSLGVVPSANVGPN--IVIGEPCHGS 298
++ N GD+ SD A GSLG++ S V P+ E HG+
Sbjct: 283 IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGT 328
>SPAC6G10.08 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 418
Score = 52.8 bits (125), Expect = 8e-07
Identities = 39/133 (29%), Positives = 68/133 (50%), Gaps = 11/133 (8%)
Query: 171 TEIATKNIATIALQIAQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEAN-KDKY 229
T+ + + A + Q+A Q+ L ++ K+ +L + DG F++ +E YE++ K K+
Sbjct: 195 TDDSIRGFAHSSFQMALQK-----KMPLYLSTKNTILKKYDGRFKDTFQEVYESDYKQKF 249
Query: 230 G--GVQYNEQIVDSMVYRMFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGP 287
G+ Y +++D MV + + F V N GD++SD A GSLG++ S + P
Sbjct: 250 EELGLWYQHRLIDDMVAQAIKSNGGF-VWACKNYDGDVMSDVVAQAYGSLGLMTSVLIHP 308
Query: 288 N--IVIGEPCHGS 298
N E HG+
Sbjct: 309 NGRTFESEAAHGT 321
>At1g65930 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 410
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/128 (31%), Positives = 65/128 (50%), Gaps = 12/128 (9%)
Query: 198 LTVTHKSNVLSQSDGLFREVCRETYEAN-KDKY--GGVQYNEQIVDSMVYRMFREPECFD 254
L ++ K+ +L + DG F+++ +E YEA+ K KY G+ Y +++D MV + +
Sbjct: 207 LYLSTKNTILKKYDGRFKDIFQEVYEASWKSKYDAAGIWYEHRLIDDMVAYALKSEGGY- 265
Query: 255 VVVAPNLYGDILSDGAAALVGSLGVVPSANVGPN--IVIGEPCHGSAP------DIAGKG 306
V N GD+ SD A GSLG++ S V P+ + E HG+ G+
Sbjct: 266 VWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGET 325
Query: 307 ISNPIATI 314
+N IA+I
Sbjct: 326 STNSIASI 333
>At1g54340 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 416
Score = 51.2 bits (121), Expect = 2e-06
Identities = 43/129 (33%), Positives = 66/129 (50%), Gaps = 14/129 (10%)
Query: 198 LTVTHKSNVLSQSDGLFREVCRETYEAN-KDKY--GGVQYNEQIVDSMV-YRMFREPECF 253
L ++ K+ +L DG F+++ +E YEAN + KY G+ Y +++D MV Y M + E
Sbjct: 208 LYLSTKNTILKIYDGRFKDIFQEVYEANWRSKYEAAGIWYEHRLIDDMVAYAM--KSEGG 265
Query: 254 DVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPN--IVIGEPCHGSAP------DIAGK 305
V N GD+ SD A GSLG++ S V P+ + E HG+ G+
Sbjct: 266 YVWACKNYDGDVQSDFLAQGYGSLGMMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGE 325
Query: 306 GISNPIATI 314
+N IA+I
Sbjct: 326 TSTNSIASI 334
>CE03436 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 412
Score = 49.7 bits (117), Expect = 7e-06
Identities = 44/154 (28%), Positives = 75/154 (48%), Gaps = 16/154 (10%)
Query: 171 TEIATKNIATIALQIAQQRLEQNGHATLTVTHKSNVLSQSDGLFREVCRETYEANKDKY- 229
T+ + ++ A + + A QR L ++ K+ +L + DG F+++ E Y + ++
Sbjct: 185 TDDSIRDFAHASFKYALQR-----KFPLYLSTKNTILKKYDGRFKDIFAEIYPEYEAEFK 239
Query: 230 -GGVQYNEQIVDSMVYRMFREPECFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGPN 288
G+ Y +++D MV + + F V N GD+ SD A GSLG++ S V P+
Sbjct: 240 AAGIWYEHRLIDDMVAQAMKSDGGF-VWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPD 298
Query: 289 --IVIGEPCHGSAP---DIAGKG---ISNPIATI 314
V E HG+ + KG +NPIA+I
Sbjct: 299 GKTVEAEAAHGTVTRHYRMHQKGQETSTNPIASI 332
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.135 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,369,191
Number of Sequences: 60738
Number of extensions: 939570
Number of successful extensions: 2359
Number of sequences better than 1.0e-05: 32
Number of HSP's better than 0.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2222
Number of HSP's gapped (non-prelim): 34
length of query: 369
length of database: 30,389,216
effective HSP length: 108
effective length of query: 261
effective length of database: 23,829,512
effective search space: 6219502632
effective search space used: 6219502632
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)