ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV2154 good B KOG1343 Chromatin structure and dynamics Histone deacetylase complex, catalytic component HDA1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV2154 754048 756159 704
(704 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL021w [B] KOG1343 Histone deacetylase complex catalytic compon... 1061 0.0
SPBC800.03 [B] KOG1343 Histone deacetylase complex catalytic com... 547 e-155
Hs13128864 [B] KOG1343 Histone deacetylase complex catalytic com... 294 4e-79
At3g18520 [B] KOG1343 Histone deacetylase complex catalytic comp... 274 4e-73
7293057 [B] KOG1343 Histone deacetylase complex catalytic compon... 270 7e-72
Hs20070354 [B] KOG1343 Histone deacetylase complex catalytic com... 265 1e-70
CE25887 [B] KOG1343 Histone deacetylase complex catalytic compon... 262 2e-69
CE20772 [B] KOG1343 Histone deacetylase complex catalytic compon... 262 2e-69
7292853 [B] KOG1343 Histone deacetylase complex catalytic compon... 253 5e-67
Hs5174481 [B] KOG1343 Histone deacetylase complex catalytic comp... 250 6e-66
Hs4885531 [B] KOG1343 Histone deacetylase complex catalytic comp... 249 1e-65
Hs13259524 [B] KOG1343 Histone deacetylase complex catalytic com... 248 2e-65
Hs13259522 [B] KOG1343 Histone deacetylase complex catalytic com... 248 2e-65
Hs21237799 [B] KOG1343 Histone deacetylase complex catalytic com... 234 3e-61
Hs17158039 [B] KOG1343 Histone deacetylase complex catalytic com... 231 3e-60
At5g61060 [B] KOG1343 Histone deacetylase complex catalytic comp... 226 7e-59
CE08062 [B] KOG1343 Histone deacetylase complex catalytic compon... 221 3e-57
At5g61070 [B] KOG1343 Histone deacetylase complex catalytic comp... 218 2e-56
CE24411 [B] KOG1343 Histone deacetylase complex catalytic compon... 197 6e-50
At4g33470 [B] KOG1343 Histone deacetylase complex catalytic comp... 171 3e-42
CE20787 [B] KOG1343 Histone deacetylase complex catalytic compon... 170 6e-42
SPAC3G9.07c [B] KOG1342 Histone deacetylase complex catalytic co... 141 3e-33
At1g08460 [B] KOG1343 Histone deacetylase complex catalytic comp... 138 3e-32
Hs17158041 [B] KOG1343 Histone deacetylase complex catalytic com... 132 1e-30
YGL194c [B] KOG1342 Histone deacetylase complex catalytic compon... 132 2e-30
YNL330c [B] KOG1342 Histone deacetylase complex catalytic compon... 128 3e-29
CE18116 [B] KOG1342 Histone deacetylase complex catalytic compon... 127 4e-29
SPBC36.05c [B] KOG1342 Histone deacetylase complex catalytic com... 125 2e-28
ECU03g1370 [B] KOG1342 Histone deacetylase complex catalytic com... 124 6e-28
Hs20551695 [B] KOG1342 Histone deacetylase complex catalytic com... 119 1e-26
Hs13128860 [B] KOG1342 Histone deacetylase complex catalytic com... 119 2e-26
CE08952 [B] KOG1342 Histone deacetylase complex catalytic compon... 118 3e-26
Hs4557641 [B] KOG1342 Histone deacetylase complex catalytic comp... 117 5e-26
7292522 [B] KOG1342 Histone deacetylase complex catalytic compon... 114 4e-25
CE01472 [B] KOG1342 Histone deacetylase complex catalytic compon... 112 3e-24
At5g63110 [B] KOG1342 Histone deacetylase complex catalytic comp... 111 3e-24
At4g38130 [B] KOG1342 Histone deacetylase complex catalytic comp... 111 3e-24
Hs13128862 [B] KOG1342 Histone deacetylase complex catalytic com... 101 3e-21
ECU09g0670 [B] KOG1342 Histone deacetylase complex catalytic com... 100 6e-21
7296744 [B] KOG1342 Histone deacetylase complex catalytic compon... 100 6e-21
Hs8923769 [B] KOG1342 Histone deacetylase complex catalytic comp... 100 1e-20
At3g44680 [B] KOG1342 Histone deacetylase complex catalytic comp... 96 1e-19
Hs13376228 [B] KOG1344 Predicted histone deacetylase 90 1e-17
At5g35600 [B] KOG1342 Histone deacetylase complex catalytic comp... 80 1e-14
YPR068c [B] KOG1342 Histone deacetylase complex catalytic compon... 70 1e-11
YPL116w [B] KOG1343 Histone deacetylase complex catalytic compon... 64 1e-09
7301219 [B] KOG1344 Predicted histone deacetylase 62 3e-09
>YNL021w [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 706
Score = 1061 bits (2743), Expect = 0.0
Identities = 496/710 (69%), Positives = 593/710 (82%), Gaps = 10/710 (1%)
Query: 1 MESKKPAEEPLERPS------IKEIKNEGTAYTLPSKDESQRPVIVPPTKPKIRYSLLKT 54
M+S +E LE P ++E K E + + SK S+R VIVP PKI YS LKT
Sbjct: 1 MDSVMVKKEVLENPDHDLKRKLEENKEEENSLSTTSK--SKRQVIVPVCMPKIHYSPLKT 58
Query: 55 GICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLM 114
G+CYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYR+YKILAENGLI DPTLSG D +GDLM
Sbjct: 59 GLCYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRIYKILAENGLINDPTLSGVDDLGDLM 118
Query: 115 VKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSC 174
+K+PVR A EEIL+VH+++HL+FI TE++ RE LLKETE GDSVYFNNDSY SA+L C
Sbjct: 119 LKIPVRAATSEEILEVHTKEHLEFIESTEKMSREELLKETEKGDSVYFNNDSYASARLPC 178
Query: 175 GGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRK 234
GGAIEACKAVVEGRVKNS+AVVRPPGHHAEP+ AGGFCLFSNVAVAA N+LK+YPESVR+
Sbjct: 179 GGAIEACKAVVEGRVKNSLAVVRPPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRR 238
Query: 235 IMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCN 294
IMI+DWDIHHGNGTQK+FY DD+VLYVSLHR+++GKYYPGTI G YDQTGEGKGEGFNCN
Sbjct: 239 IMILDWDIHHGNGTQKSFYQDDQVLYVSLHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCN 298
Query: 295 ITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHM 354
ITWP GGVGDAEYMWAFEQV+MPMGREF+PDLV+ISSGFDAADGDTIGQCHVTP+CYGHM
Sbjct: 299 ITWPVGGVGDAEYMWAFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVTPSCYGHM 358
Query: 355 THMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKKQPTPEAKKMIE 414
THML SLA+GNLCVVLEGGYNLD+IA+SAL V KVL+GEPPDELP P P PE +MI+
Sbjct: 359 THMLKSLARGNLCVVLEGGYNLDAIARSALSVAKVLIGEPPDELPDPLSDPKPEVIEMID 418
Query: 415 TVIRTQSKYWSCFKNRHGNDGINFKDAITSTLDTRNFPLQNAIREYQVSQLSSQFNFVQL 474
VIR QSKYW+CF+ RH N G NF + I ++ ++NFPLQ AIR+ Q LS +FNFV L
Sbjct: 419 KVIRLQSKYWNCFRRRHANSGCNFNEPINDSIISKNFPLQKAIRQQQQHYLSDEFNFVTL 478
Query: 475 PILDLNLPANTMLCTSGIQDSETLVVIVHDTPEIWSERDTQTGIIDPSSSIIVDNALKMI 534
P++ ++LP NT+LCT I +S T++++VHDT +IW++R+ +G ID SSS+I+DN+L I
Sbjct: 479 PLVSMDLPDNTVLCTPNISESNTIIIVVHDTSDIWAKRNVISGTIDLSSSVIIDNSLDFI 538
Query: 535 NWAMDRRYGIIDINIPQTLFEHANYPGVASSQEILIYLWDNYLKFFQNLQKVAFIGIGDA 594
W +DR+YGIID+NIP TLFE NY G+ +SQE+LIYLWDNY+K+F ++ K+AFIGIGD+
Sbjct: 539 KWGLDRKYGIIDVNIPLTLFEPDNYSGMITSQEVLIYLWDNYIKYFPSVAKIAFIGIGDS 598
Query: 595 YGGIVHLLGHRDTRSVVKCAISFLDKKPLKVMVPLIDETLGDWYFKNSLVFTSSTHSCWG 654
Y GIVHLLGHRDTR+V K I+FL K LK +VPL+DETL +WYFKNSL+F++++H CW
Sbjct: 599 YSGIVHLLGHRDTRAVTKTVINFLGDKQLKPLVPLVDETLSEWYFKNSLIFSNNSHQCW- 657
Query: 655 STANENKKLRKKYGRVLKADCDGMTNIFDERFEEATDFILDSFEEWSESE 704
NE++K RKK+GRVL+ D DG+ NI +ERFEEATDFILDSFEEWS+ E
Sbjct: 658 -KENESRKPRKKFGRVLRCDTDGLNNIIEERFEEATDFILDSFEEWSDEE 706
>SPBC800.03 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 687
Score = 547 bits (1409), Expect = e-155
Identities = 275/649 (42%), Positives = 414/649 (63%), Gaps = 31/649 (4%)
Query: 51 LLKTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSI 110
L K+G+CYD RMR+HA + +D HPEDPRR+ RV++ + + G + S S
Sbjct: 54 LKKSGLCYDPRMRFHATL-----SEVDDHPEDPRRVLRVFEAIKKAGYV-----SNVPSP 103
Query: 111 GDLMVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSA 170
D+ +++P REA EE+LQVHS++ D ++ TE++ E L + DS+Y+NN+S A
Sbjct: 104 SDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKISDSLYYNNESAFCA 163
Query: 171 KLSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPE 230
+L+CG AIE C AVV G+VKN+ AVVRPPGHHAEP GGFCLF+NV+V A +ML+ +P+
Sbjct: 164 RLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPD 223
Query: 231 SVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEG 290
+++++IVDWDIHHGNGTQ AFYDD VLYVSLHRY+ G++YPGT +G + GEG G G
Sbjct: 224 KIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLG 283
Query: 291 FNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPAC 350
NI W G+GD +Y++AF++V+MP+ EF+PDLV++S GFDAA GD IGQ +TPA
Sbjct: 284 RTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAA 343
Query: 351 YGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKKQPTPEAK 410
Y HMT ML+ LA G + + LEGGYNLDSI+ SAL V + L+G PP L P+A
Sbjct: 344 YAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGRLHT--TYACPQAV 401
Query: 411 KMIETVIRTQSKYWSCFKNRHGNDGINFKDAITSTLDTRNFPLQNAIREYQVSQLSSQFN 470
I V + QS+YW C + +H + N KDA L + IR YQ +L +
Sbjct: 402 ATINHVTKIQSQYWRCMRPKHFD--ANPKDAHVDR-------LHDVIRTYQAKKLFEDWK 452
Query: 471 FVQLPILD---LNLPANTMLCTSGIQDSETLVVIVHDTPEIWSERDTQTGIIDPSSSIIV 527
+PIL N+ N +LC+S + L+VIVH++P + ++T +++ + S++V
Sbjct: 453 ITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSLLV 512
Query: 528 DNALKMINWAMDRRYGIIDINIPQTLFEHANYPG--VASSQEILIYLWDNYLKFFQNLQK 585
D + WAM + +G+IDINIP+ + + N P ++ +E+ +Y+WDNY++ + +
Sbjct: 513 DPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSIS-KN 571
Query: 586 VAFIGIGDAYGGIVHLLGHRDTRSVVKCAISFLDKKPLKVMVPLIDETLGDWYFKNSLVF 645
+ FIG G A G+V+L R+ VKC ++FL +PL + +E L WY+++SLVF
Sbjct: 572 IFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLVF 631
Query: 646 TSSTHSCWGSTANENKKLRKKYGRVLKADCDGMTNIFDERFEEATDFIL 694
SS++ CW + K+ +++YGR+++++ +++ ++ + T ++L
Sbjct: 632 VSSSNECW----KKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLL 676
>Hs13128864 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1215
Score = 294 bits (752), Expect = 4e-79
Identities = 166/426 (38%), Positives = 242/426 (55%), Gaps = 24/426 (5%)
Query: 1 MESKKPAEEPLERPSIKEIKNEGTAYTLPSKDESQRPVIVPPTKPKIRYSLL--KTGICY 58
+E+ +P E L R S + ++ + + E + P PP P + + +L +TG+ Y
Sbjct: 428 LEALEPFWEVLVR-STETVERDNMEEDNVEESEEEGPW-EPPVLPILTWPVLQSRTGLVY 485
Query: 59 DVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVP 118
D M H ++ S+ HPE P+RI R+ L E GL G + P
Sbjct: 486 DQNMMNHCNLWDSH------HPEVPQRILRIMCRLEELGLA-----------GRCLTLTP 528
Query: 119 VREAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAI 178
R A E E+L HS +++ + TE+++ L +E+ DS+Y ++ A+L+ G A
Sbjct: 529 -RPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAAC 587
Query: 179 EACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIV 238
+AV+ G V N AVVRPPGHHAE + A GFC F++VAVAA + ++R I+IV
Sbjct: 588 RLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALR-ILIV 646
Query: 239 DWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWP 298
DWD+HHGNGTQ F DD VLYVSLHRY G ++P G Q G G GF N+ W
Sbjct: 647 DWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWN 706
Query: 299 TGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHML 358
+GDA+Y+ A+ ++++P+ EF P+LVL+S+GFDAA GD +G C V+P Y H+TH+L
Sbjct: 707 GPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLL 766
Query: 359 LSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKKQPTPEAKKMIETVIR 418
+ LA G + ++LEGGYNL SI++S + L+G+PP L P + P A I I+
Sbjct: 767 MGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLP-RPPLSGALASITETIQ 825
Query: 419 TQSKYW 424
+YW
Sbjct: 826 VHRRYW 831
Score = 257 bits (657), Expect = 4e-68
Identities = 141/422 (33%), Positives = 227/422 (53%), Gaps = 24/422 (5%)
Query: 5 KPAEEPLERPSIKEIKNEGTAYTLPSKDESQRPVIVPPTKPKIRYSLLK-TGICYDVRMR 63
K P P++ E+K +G L E V + + L TG+ D ++
Sbjct: 36 KKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLN 95
Query: 64 -YHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREA 122
+H + D PE P R++ + + L + GL+ D V R A
Sbjct: 96 EFHCL-------WDDSFPEGPERLHAIKEQLIQEGLL------------DRCVSFQARFA 136
Query: 123 EEEEILQVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACK 182
E+EE++ VHS +++D + T+ + L + DSVY + +SY A L+ G +
Sbjct: 137 EKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVD 196
Query: 183 AVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDI 242
AV+ ++N +A++RPPGHHA+ + G+C+F++VAVAA + + +R+++IVDWD+
Sbjct: 197 AVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKH--RIRRVLIVDWDV 254
Query: 243 HHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGV 302
HHG GTQ F D VLY S+HRY+ G+++P N+ TG G+G+G+ N+ W G+
Sbjct: 255 HHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGM 314
Query: 303 GDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLA 362
DA+Y+ AF V++P+ EF+P LVL+++GFDA GD G+ TPA + +TH+L+ LA
Sbjct: 315 RDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLA 374
Query: 363 KGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKKQPTPEAKKMIETVIRTQSK 422
G L + LEGGYNL ++A+ L+G+P L +P P A+ + +
Sbjct: 375 GGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESP-GAPCRSAQASVSCALEALEP 433
Query: 423 YW 424
+W
Sbjct: 434 FW 435
>At3g18520 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 561
Score = 274 bits (700), Expect = 4e-73
Identities = 156/381 (40%), Positives = 214/381 (55%), Gaps = 33/381 (8%)
Query: 54 TGICYDVRMRYHAKIF--------TSYFEY-IDPHPEDPRRIYRVYKILAENGLIQDPTL 104
T + +D RM H++ F FE PHPE P R+ + LA G+ L
Sbjct: 146 TAVGFDERMLLHSEFFYLICADGMLKKFEVKAQPHPERPDRLRAIAASLATAGVFPGRCL 205
Query: 105 SGADSIGDLMVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNN 164
+ RE ++E+ VH+ +H+D + T QL +T Y N
Sbjct: 206 P-----------INAREITKQELQMVHTSEHVDAVDTTSQLLYSYFTSDT------YANE 248
Query: 165 DSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANM 224
S +A+L+ G + + GRVKN A+VRPPGHHA A GFCL +N AVAA
Sbjct: 249 YSARAARLAAGLCADLATDIFTGRVKNGFALVRPPGHHAGVRHAMGFCLHNNAAVAA--- 305
Query: 225 LKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTG 284
L + +K++IVDWD+HHGNGTQ+ F + VLY+SLHR++ G +YPGT G D+ G
Sbjct: 306 LVAQAAGAKKVLIVDWDVHHGNGTQEIFEQNKSVLYISLHRHEGGNFYPGT--GAADEVG 363
Query: 285 EGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQC 344
GEG+ N+ W GGVGD +Y++AF+ V++P+ F PD V+IS+GFDAA GD +G C
Sbjct: 364 SNGGEGYCVNVPWSCGGVGDKDYIFAFQHVVLPIASAFSPDFVIISAGFDAARGDPLGCC 423
Query: 345 HVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGE-PPDELPAPKK 403
VTPA Y MT ML L G + V+LEGGYNL SI+ SA V KVL+GE P +ELP
Sbjct: 424 DVTPAGYSRMTQMLGDLCGGKMLVILEGGYNLRSISASATAVIKVLLGENPENELPI-AT 482
Query: 404 QPTPEAKKMIETVIRTQSKYW 424
P+ + + V+ Q ++W
Sbjct: 483 TPSVAGLQTVLDVLNIQLEFW 503
>7293057 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 883
Score = 270 bits (689), Expect = 7e-72
Identities = 150/423 (35%), Positives = 234/423 (54%), Gaps = 35/423 (8%)
Query: 14 PSIKEIKNEGTAYTLPSKDESQRPVIVPPTKPKIRYSLLKTGICY--DVRMRYHAKIFTS 71
P + TA LP + + + + + + S+ +CY D +M H + +
Sbjct: 417 PPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLNDT 476
Query: 72 YFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVH 131
HPE P RI ++K+ + GL++ M ++ R A +E+ H
Sbjct: 477 ------GHPEQPSRIQHIHKMHDDYGLLKQ------------MKQLSPRAATTDEVCLAH 518
Query: 132 SRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKN 191
+R H++ + + E + L +SVY + ++ A L+ G ++A +V+ G ++
Sbjct: 519 TRAHVNTVRRLLGREPKELHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRS 578
Query: 192 SIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKA 251
I VRPPGHHAE + GFC+F+NVA+AA ++ + + +++IVDWD+HHGNGTQ
Sbjct: 579 GICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDF--GLERVLIVDWDVHHGNGTQHI 636
Query: 252 FYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAF 311
F + +VLY+SLHRY+ G ++P GN+D G+G G GFN NI W G+GD EY AF
Sbjct: 637 FESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAF 696
Query: 312 EQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLE 371
+Q+IMP+ EF P LVL+S+GFDAA GD +G C VT YG +TH L +LA G + V LE
Sbjct: 697 QQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLE 756
Query: 372 GGYNLDSIAKSALGVCKVLVGEPPDELPAP-------KKQPTPEAKKMIETV---IRTQS 421
GGYN++SI+ + K L+G+P +P P +K PT + +E++ ++ Q
Sbjct: 757 GGYNVNSISYAMTMCTKTLLGDP---VPTPQLGATALQKPPTVAFQSCVESLQQCLQVQR 813
Query: 422 KYW 424
+W
Sbjct: 814 NHW 816
Score = 245 bits (625), Expect = 2e-64
Identities = 127/388 (32%), Positives = 216/388 (54%), Gaps = 21/388 (5%)
Query: 54 TGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDL 113
T + YD M H ++ H E P R RV + E L +
Sbjct: 31 TALIYDESMSQHCCLWDK------EHYECPERFTRVLERCRELNLTER------------ 72
Query: 114 MVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGG-DSVYFNNDSYLSAKL 172
+++P R A ++EIL++H+ +H + + +T + + ++E DS+Y + ++ + L
Sbjct: 73 CLELPSRSATKDEILRLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLL 132
Query: 173 SCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESV 232
+ G IE +V G+ +N +A++RPPGHHA G+C F+NVA+A + L + +
Sbjct: 133 ASGSTIELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVH--KL 190
Query: 233 RKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFN 292
++I+I+D+D+HHG GTQ+ FY+D RV+Y S+HR++ G ++P +Y G G G G+N
Sbjct: 191 QRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIGSGAGTGYN 250
Query: 293 CNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYG 352
N+ G+ + +Y+ F+Q+++P+ EF+P+L+++S+G+DAA G G+ VTPACY
Sbjct: 251 FNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYP 310
Query: 353 HMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKKQPTPEAKKM 412
H+ + LL LA + VVLEGGY LDS+A+ A + L+G+P L P E +
Sbjct: 311 HLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQA 370
Query: 413 IETVIRTQSKYWSCFKNRHGNDGINFKD 440
+ + I +W C + + D + +D
Sbjct: 371 LLSCIAVHRPHWRCLQLQQTYDCVELQD 398
>Hs20070354 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 669
Score = 265 bits (678), Expect = 1e-70
Identities = 136/369 (36%), Positives = 216/369 (57%), Gaps = 17/369 (4%)
Query: 64 YHAKIFTSYFEYIDPHPE--DPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVRE 121
YH + + + DP E P R+ L + GL Q +++ RE
Sbjct: 7 YHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQR------------CLRLSARE 54
Query: 122 AEEEEILQVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEAC 181
A EEE+ VHS +++ + +T+ L +E L + D++YF+ ++ A+L+ G ++
Sbjct: 55 ASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLV 114
Query: 182 KAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWD 241
AV+ G V+N +A+VRPPGHH + A GFC+F+NVA+AAA+ + + + +I++VDWD
Sbjct: 115 DAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKH--GLHRILVVDWD 172
Query: 242 IHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGG 301
+HHG G Q F DD VLY S HRY+ G+++P + D G G+G GF N+ W G
Sbjct: 173 VHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVG 232
Query: 302 VGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSL 361
+G+A+Y+ AF +++P+ EF+P+LVL+S+GFD+A GD GQ TP C+ H+T +L L
Sbjct: 233 MGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVL 292
Query: 362 AKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKKQPTPEAKKMIETVIRTQS 421
A G +C VLEGGY+L+S+A+S + L+G+P L P P A + I++ Q+
Sbjct: 293 AGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGP-MAPCQSALESIQSARAAQA 351
Query: 422 KYWSCFKNR 430
+W + +
Sbjct: 352 PHWKSLQQQ 360
>CE25887 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 955
Score = 262 bits (669), Expect = 2e-69
Identities = 141/363 (38%), Positives = 209/363 (56%), Gaps = 24/363 (6%)
Query: 77 DPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHSRQHL 136
D HPE P R R+ K L E+G+++ + I A EEI VH+++ L
Sbjct: 444 DNHPEKPARTRRILKTLRESGVLEKCVDRNCERI-----------ATNEEIRLVHTKKML 492
Query: 137 DFISQTEQLERESLLKETEGG-DSVYFNNDSYLSAKLSCGGAIEACKAVVEGRV--KNSI 193
+ + TE ++ E L++E E +S+Y D+ A+ + G +++ + E +N++
Sbjct: 493 EHLRTTETMKDEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNAL 552
Query: 194 AVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFY 253
+VRPPGHHA + GFC+F+NVAVAA + + ++++I+DWD+HHGNGTQ+ FY
Sbjct: 553 VIVRPPGHHASASKSSGFCIFNNVAVAAKYAQRRH--KAKRVLILDWDVHHGNGTQEIFY 610
Query: 254 DDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQ 313
+D V+Y+S+HR+ G +YP +Y GEG GEG + N+ + +GD EY AF++
Sbjct: 611 EDSNVMYMSIHRHDKGNFYPIGEPKDYSDVGEGAGEGMSVNVPFSGVQMGDNEYQMAFQR 670
Query: 314 VIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGG 373
VIMP+ +F PDLVLIS+GFDAA D +G+ VTP + MT+ L SLA G + VLEGG
Sbjct: 671 VIMPIAYQFNPDLVLISAGFDAAVDDPLGEYKVTPETFALMTYQLSSLAGGRIITVLEGG 730
Query: 374 YNLDSIAKSALGVCKVL--------VGEPPDELPAPKKQPTPEAKKMIETVIRTQSKYWS 425
YNL SI+ SA VC+VL + E ++ ++ K I V Q KYWS
Sbjct: 731 YNLTSISNSAQAVCEVLQNRSMLRRLREEKEQFATKPQKIESSCIKTIREVCAVQQKYWS 790
Query: 426 CFK 428
K
Sbjct: 791 ILK 793
Score = 214 bits (544), Expect = 5e-55
Identities = 122/351 (34%), Positives = 190/351 (53%), Gaps = 19/351 (5%)
Query: 79 HPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHSRQHLDF 138
HPE RI ++ + L + +++ T V E ++ ++ H + +
Sbjct: 34 HPESSDRILKIKEALTKTKILEKCT-----------VLTNFLEIDDADLEVTHDKSMVKD 82
Query: 139 ISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRP 198
+ ++E+ +E + + E DSV+ +S AK + ++ N AVVRP
Sbjct: 83 LMESEKKTQEDINSQCEKYDSVFMTENSMKVAKDGVACVRDLTNRIMANEASNGFAVVRP 142
Query: 199 PGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRV 258
PGHHA+ GFCLF+NVA AA S E +I+IVD D+HHG+GTQ+ FYDD RV
Sbjct: 143 PGHHADSVSPCGFCLFNNVAQAAEEAFFSGAE---RILIVDLDVHHGHGTQRIFYDDKRV 199
Query: 259 LYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMPM 318
LY S+HR++ G ++P ++D G GKG G+N N+ G D++Y+ V++P+
Sbjct: 200 LYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGCTDSDYLSIIFHVLLPL 259
Query: 319 GREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDS 378
+F+P V+IS+GFDA GD +G +TP Y H+ + L SLA+G + VVLEGGYN
Sbjct: 260 ATQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILYHLKSLAQGRMLVVLEGGYNHQI 319
Query: 379 IAKSALGVCKVLVGEPP--DELPAPKKQPTPEAKKMIETVIRTQSKYWSCF 427
A + +VL+G P EL K+ T ++ + +V+R +W+CF
Sbjct: 320 SAVAVQRCVRVLLGYAPFSIELNEAPKESTVDSCVSLVSVLR---HHWNCF 367
>CE20772 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 863
Score = 262 bits (669), Expect = 2e-69
Identities = 141/363 (38%), Positives = 209/363 (56%), Gaps = 24/363 (6%)
Query: 77 DPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHSRQHL 136
D HPE P R R+ K L E+G+++ + I A EEI VH+++ L
Sbjct: 444 DNHPEKPARTRRILKTLRESGVLEKCVDRNCERI-----------ATNEEIRLVHTKKML 492
Query: 137 DFISQTEQLERESLLKETEGG-DSVYFNNDSYLSAKLSCGGAIEACKAVVEGRV--KNSI 193
+ + TE ++ E L++E E +S+Y D+ A+ + G +++ + E +N++
Sbjct: 493 EHLRTTETMKDEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNAL 552
Query: 194 AVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFY 253
+VRPPGHHA + GFC+F+NVAVAA + + ++++I+DWD+HHGNGTQ+ FY
Sbjct: 553 VIVRPPGHHASASKSSGFCIFNNVAVAAKYAQRRH--KAKRVLILDWDVHHGNGTQEIFY 610
Query: 254 DDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQ 313
+D V+Y+S+HR+ G +YP +Y GEG GEG + N+ + +GD EY AF++
Sbjct: 611 EDSNVMYMSIHRHDKGNFYPIGEPKDYSDVGEGAGEGMSVNVPFSGVQMGDNEYQMAFQR 670
Query: 314 VIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGG 373
VIMP+ +F PDLVLIS+GFDAA D +G+ VTP + MT+ L SLA G + VLEGG
Sbjct: 671 VIMPIAYQFNPDLVLISAGFDAAVDDPLGEYKVTPETFALMTYQLSSLAGGRIITVLEGG 730
Query: 374 YNLDSIAKSALGVCKVL--------VGEPPDELPAPKKQPTPEAKKMIETVIRTQSKYWS 425
YNL SI+ SA VC+VL + E ++ ++ K I V Q KYWS
Sbjct: 731 YNLTSISNSAQAVCEVLQNRSMLRRLREEKEQFATKPQKIESSCIKTIREVCAVQQKYWS 790
Query: 426 CFK 428
K
Sbjct: 791 ILK 793
Score = 214 bits (544), Expect = 5e-55
Identities = 122/351 (34%), Positives = 190/351 (53%), Gaps = 19/351 (5%)
Query: 79 HPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHSRQHLDF 138
HPE RI ++ + L + +++ T V E ++ ++ H + +
Sbjct: 34 HPESSDRILKIKEALTKTKILEKCT-----------VLTNFLEIDDADLEVTHDKSMVKD 82
Query: 139 ISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRP 198
+ ++E+ +E + + E DSV+ +S AK + ++ N AVVRP
Sbjct: 83 LMESEKKTQEDINSQCEKYDSVFMTENSMKVAKDGVACVRDLTNRIMANEASNGFAVVRP 142
Query: 199 PGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRV 258
PGHHA+ GFCLF+NVA AA S E +I+IVD D+HHG+GTQ+ FYDD RV
Sbjct: 143 PGHHADSVSPCGFCLFNNVAQAAEEAFFSGAE---RILIVDLDVHHGHGTQRIFYDDKRV 199
Query: 259 LYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMPM 318
LY S+HR++ G ++P ++D G GKG G+N N+ G D++Y+ V++P+
Sbjct: 200 LYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGCTDSDYLSIIFHVLLPL 259
Query: 319 GREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDS 378
+F+P V+IS+GFDA GD +G +TP Y H+ + L SLA+G + VVLEGGYN
Sbjct: 260 ATQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILYHLKSLAQGRMLVVLEGGYNHQI 319
Query: 379 IAKSALGVCKVLVGEPP--DELPAPKKQPTPEAKKMIETVIRTQSKYWSCF 427
A + +VL+G P EL K+ T ++ + +V+R +W+CF
Sbjct: 320 SAVAVQRCVRVLLGYAPFSIELNEAPKESTVDSCVSLVSVLR---HHWNCF 367
>7292853 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1235
Score = 253 bits (647), Expect = 5e-67
Identities = 151/396 (38%), Positives = 221/396 (55%), Gaps = 40/396 (10%)
Query: 54 TGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDL 113
TG+ YD M H+ I + HPE R+ V+ L E L++
Sbjct: 822 TGLAYDPLMLKHSCICGDNAQ----HPEHSGRLQSVWARLNETDLVKRCD---------- 867
Query: 114 MVKVPVREAEEEEILQVHSRQH-LDFISQTEQLERESL--------LKETEGG-----DS 159
++ R+A +EE+ VH+ H + F S QL R L ++ + GG D+
Sbjct: 868 --RLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDT 925
Query: 160 VYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAV 219
+ + + +A+++ G I+ +G ++N AVVRPPGHHAE +A GFC F+++A+
Sbjct: 926 TWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAI 985
Query: 220 AAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGN 279
AA + + PE VR+I+IVDWD+HHGNGTQ+AFY +LY+S+HR+ G ++PGT G
Sbjct: 986 AAKLLRQRMPE-VRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGT--GG 1042
Query: 280 YDQTGEGKGEGFNCNITWP---TGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAA 336
+ G G G GFN NI+W +GDAEY+ AF V+MP+ R F PD+VL+SSGFDAA
Sbjct: 1043 PTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAA 1102
Query: 337 DGD--TIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEP 394
G +G HV+PAC+G MT LL LA G + + LEGGY+L +I SA + L+G+P
Sbjct: 1103 TGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDP 1162
Query: 395 --PDELPAPKKQPTPEAKKMIETVIRTQSKYWSCFK 428
P ++ P A ++ I Q +W C +
Sbjct: 1163 AAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVR 1198
>Hs5174481 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1084
Score = 250 bits (638), Expect = 6e-66
Identities = 162/429 (37%), Positives = 227/429 (52%), Gaps = 53/429 (12%)
Query: 41 PPTKPKIRYSLLKTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQ 100
PPTKP+ TG+ YD M H S HPE RI ++ L E GL
Sbjct: 646 PPTKPRFT-----TGLVYDTLMLKHQCTCGSS----SSHPEHAGRIQSIWSRLQETGLRG 696
Query: 101 DPTLSGADSIGDLMVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESL---------- 150
+ R+A EE+ VHS H + T L R+ L
Sbjct: 697 KCEC------------IRGRKATLEELQTVHSEAHT-LLYGTNPLNRQKLDSKKLLGSLA 743
Query: 151 ---LKETEGG-----DSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGHH 202
++ GG D+++ S +A+L+ G +E V G +KN AVVRPPGHH
Sbjct: 744 SVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHH 803
Query: 203 AEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVS 262
AE GFC F++VAVAA + + SV KI+IVDWD+HHGNGTQ+AFY D VLY+S
Sbjct: 804 AEESTPMGFCYFNSVAVAAKLLQQRL--SVSKILIVDWDVHHGNGTQQAFYSDPSVLYMS 861
Query: 263 LHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGG----VGDAEYMWAFEQVIMPM 318
LHRY G ++PG+ G D+ G G G GFN N+ + TGG +GDAEY+ AF V+MP+
Sbjct: 862 LHRYDDGNFFPGS--GAPDEVGTGPGVGFNVNMAF-TGGLDPPMGDAEYLAAFRTVVMPI 918
Query: 319 GREFEPDLVLISSGFDAADG--DTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNL 376
EF PD+VL+SSGFDA +G +G +++ C+G++T L+ LA G + + LEGG++L
Sbjct: 919 ASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDL 978
Query: 377 DSIAKSALGVCKVLVGEPPDELPAP--KKQPTPEAKKMIETVIRTQSKYWSCFKNRHGND 434
+I ++ L+G D LP +++P A + +E V+ SKYW C +
Sbjct: 979 TAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTA 1038
Query: 435 GINFKDAIT 443
G + +A T
Sbjct: 1039 GRSLIEAQT 1047
>Hs4885531 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1122
Score = 249 bits (636), Expect = 1e-65
Identities = 156/429 (36%), Positives = 229/429 (53%), Gaps = 53/429 (12%)
Query: 41 PPTKPKIRYSLLKTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQ 100
PP +P +++ L TG+ YD M H + + HPE RI ++ L E GL+
Sbjct: 672 PPDQP-VKH-LFTTGVVYDTFMLKHQCMCGN----THVHPEHAGRIQSIWSRLQETGLLS 725
Query: 101 DPTLSGADSIGDLMVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGG--- 157
++ R+A +EI VHS H + T L R+ L + G
Sbjct: 726 K------------CERIRGRKATLDEIQTVHSEYHT-LLYGTSPLNRQKLDSKKLLGPIS 772
Query: 158 ----------------DSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGH 201
D+V+ S + +++ G +E V G +KN A++RPPGH
Sbjct: 773 QKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGH 832
Query: 202 HAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYV 261
HAE A GFC F++VA+ A + + +V K++IVDWDIHHGNGTQ+AFY+D VLY+
Sbjct: 833 HAEESTAMGFCFFNSVAITAKLLQQKL--NVGKVLIVDWDIHHGNGTQQAFYNDPSVLYI 890
Query: 262 SLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGV----GDAEYMWAFEQVIMP 317
SLHRY G ++PG+ G ++ G G G G+N N+ W TGGV GD EY+ AF V+MP
Sbjct: 891 SLHRYDNGNFFPGS--GAPEEVGGGPGVGYNVNVAW-TGGVDPPIGDVEYLTAFRTVVMP 947
Query: 318 MGREFEPDLVLISSGFDAADG--DTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYN 375
+ EF PD+VL+S+GFDA +G +G VT C+GH+T L++LA G + + LEGG++
Sbjct: 948 IAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHD 1007
Query: 376 LDSIAKSALGVCKVLVG---EPPDELPAPKKQPTPEAKKMIETVIRTQSKYWSCFKNRHG 432
L +I ++ L+ +P DE +K P A +E VI QSK+WSC +
Sbjct: 1008 LTAICDASEACVSALLSVELQPLDEAVLQQK-PNINAVATLEKVIEIQSKHWSCVQKFAA 1066
Query: 433 NDGINFKDA 441
G + ++A
Sbjct: 1067 GLGRSLREA 1075
>Hs13259524 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 912
Score = 248 bits (634), Expect = 2e-65
Identities = 158/450 (35%), Positives = 228/450 (50%), Gaps = 49/450 (10%)
Query: 6 PAEEPLERPSIKEIKNEGTAYTLPSKDESQRPVIVPPTKPKIRYSLLKTGICYDVRMRYH 65
P + RP + + +L + + + + ++ ++ R TG+ YD M H
Sbjct: 432 PLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKH 491
Query: 66 AKIFTSYFEYIDPHPEDPRRIYRVYKILAENGL-IQDPTLSGADSIGDLMVKVPVREAEE 124
HPE RI ++ L E GL Q L G R+A
Sbjct: 492 QCSCGDNSR----HPEHAGRIQSIWSRLQERGLRSQCECLRG-------------RKASL 534
Query: 125 EEILQVHSRQHLDFISQTEQLERESLLKETEGG-------------------DSVYFNND 165
EE+ VHS +H+ + T L R L G D+++
Sbjct: 535 EELQSVHSERHV-LLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELH 593
Query: 166 SYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANML 225
S +A+ + G + V +KN AVVRPPGHHA+ A GFC F++VA+A +
Sbjct: 594 SSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQ 653
Query: 226 KSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGE 285
+ S KI+IVDWD+HHGNGTQ+ FY D VLY+SLHR+ G ++PG+ G D+ G
Sbjct: 654 QQSKAS--KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS--GAVDEVGA 709
Query: 286 GKGEGFNCNITWPTG---GVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGD--T 340
G GEGFN N+ W G +GD EY+ AF V+MP+ REF PDLVL+S+GFDAA+G
Sbjct: 710 GSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAP 769
Query: 341 IGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPA 400
+G HV+ C+G+MT L++LA G + + LEGG++L +I ++ L+G D L
Sbjct: 770 LGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSE 829
Query: 401 P--KKQPTPEAKKMIETVIRTQSKYWSCFK 428
K++P A + +E VIR SKYW C +
Sbjct: 830 EGWKQKPNLNAIRSLEAVIRVHSKYWGCMQ 859
>Hs13259522 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 952
Score = 248 bits (634), Expect = 2e-65
Identities = 158/450 (35%), Positives = 228/450 (50%), Gaps = 49/450 (10%)
Query: 6 PAEEPLERPSIKEIKNEGTAYTLPSKDESQRPVIVPPTKPKIRYSLLKTGICYDVRMRYH 65
P + RP + + +L + + + + ++ ++ R TG+ YD M H
Sbjct: 472 PLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKH 531
Query: 66 AKIFTSYFEYIDPHPEDPRRIYRVYKILAENGL-IQDPTLSGADSIGDLMVKVPVREAEE 124
HPE RI ++ L E GL Q L G R+A
Sbjct: 532 QCSCGDNSR----HPEHAGRIQSIWSRLQERGLRSQCECLRG-------------RKASL 574
Query: 125 EEILQVHSRQHLDFISQTEQLERESLLKETEGG-------------------DSVYFNND 165
EE+ VHS +H+ + T L R L G D+++
Sbjct: 575 EELQSVHSERHV-LLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELH 633
Query: 166 SYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANML 225
S +A+ + G + V +KN AVVRPPGHHA+ A GFC F++VA+A +
Sbjct: 634 SSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQ 693
Query: 226 KSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGE 285
+ S KI+IVDWD+HHGNGTQ+ FY D VLY+SLHR+ G ++PG+ G D+ G
Sbjct: 694 QQSKAS--KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGS--GAVDEVGA 749
Query: 286 GKGEGFNCNITWPTG---GVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGD--T 340
G GEGFN N+ W G +GD EY+ AF V+MP+ REF PDLVL+S+GFDAA+G
Sbjct: 750 GSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAP 809
Query: 341 IGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPA 400
+G HV+ C+G+MT L++LA G + + LEGG++L +I ++ L+G D L
Sbjct: 810 LGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSE 869
Query: 401 P--KKQPTPEAKKMIETVIRTQSKYWSCFK 428
K++P A + +E VIR SKYW C +
Sbjct: 870 EGWKQKPNLNAIRSLEAVIRVHSKYWGCMQ 899
>Hs21237799 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1037
Score = 234 bits (598), Expect = 3e-61
Identities = 124/293 (42%), Positives = 180/293 (61%), Gaps = 15/293 (5%)
Query: 158 DSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNV 217
D+V+ S + +++ G +E V G +KN A++RPPGHHAE A GFC F++V
Sbjct: 704 DTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSV 763
Query: 218 AVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIH 277
A+ A + + +V K++IVDWDIHHGNGTQ+AFY+D VLY+SLHRY G ++PG+
Sbjct: 764 AITAKLLQQKL--NVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS-- 819
Query: 278 GNYDQTGEGKGEGFNCNITWPTGGV----GDAEYMWAFEQVIMPMGREFEPDLVLISSGF 333
G ++ G G G G+N N+ W TGGV GD EY+ AF V+MP+ EF PD+VL+S+GF
Sbjct: 820 GAPEEVGGGPGVGYNVNVAW-TGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGF 878
Query: 334 DAADG--DTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLV 391
DA +G +G VT C+GH+T L++LA G + + LEGG++L +I ++ L+
Sbjct: 879 DAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALL 938
Query: 392 G---EPPDELPAPKKQPTPEAKKMIETVIRTQSKYWSCFKNRHGNDGINFKDA 441
+P DE +K P A +E VI QSK+WSC + G + ++A
Sbjct: 939 SVELQPLDEAVLQQK-PNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREA 990
>Hs17158039 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1011
Score = 231 bits (589), Expect = 3e-60
Identities = 144/394 (36%), Positives = 210/394 (52%), Gaps = 47/394 (11%)
Query: 54 TGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDL 113
TGI YD M H + + HPE RI ++ L E GL+
Sbjct: 633 TGIAYDPLMLKHQCVCGNS----TTHPEHAGRIQSIWSRLQETGLLNK------------ 676
Query: 114 MVKVPVREAEEEEILQVHSRQHLDFISQT----EQLERESLLKETE---------GG--- 157
++ R+A EEI VHS H ++L+ LL + GG
Sbjct: 677 CERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGV 736
Query: 158 --DSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFS 215
D+++ S +A+++ G IE V G +KN AVVRPPGHHAE A GFC F+
Sbjct: 737 DSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFN 796
Query: 216 NVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGT 275
+VA+ A + ++ KI+IVD D+HHGNGTQ+AFY D +LY+SLHRY G ++PG+
Sbjct: 797 SVAITAKYLRDQL--NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGS 854
Query: 276 IHGNYDQTGEGKGEGFNCNITWPTGG----VGDAEYMWAFEQVIMPMGREFEPDLVLISS 331
G ++ G G GEG+N NI W TGG +GD EY+ AF ++ P+ +EF+PD+VL+S+
Sbjct: 855 --GAPNEVGTGLGEGYNINIAW-TGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSA 911
Query: 332 GFDAADGDT--IGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKV 389
GFDA +G T +G VT C+GH+T L++LA G + + LEGG++L +I ++
Sbjct: 912 GFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNA 971
Query: 390 LVGEPPDELPAP--KKQPTPEAKKMIETVIRTQS 421
L+G + L + P A ++ +I QS
Sbjct: 972 LLGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005
>At5g61060 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 717
Score = 226 bits (577), Expect = 7e-59
Identities = 144/418 (34%), Positives = 213/418 (50%), Gaps = 72/418 (17%)
Query: 53 KTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGD 112
K G+ YD M H + HPE P RI +++ L G+ Q + G+
Sbjct: 26 KVGLIYDETMCKHDTPDG------EDHPECPDRIRVIWEKLQLAGVSQRCVVLGSS---- 75
Query: 113 LMVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGG-DSVYFNNDSYLSAK 171
+AE++ + VH++ H++ + +++ +S+Y N S +A
Sbjct: 76 --------KAEDKHLQLVHTKDHVNLVKSISTKQKDYRRNRIASQLNSIYLNGGSSEAAY 127
Query: 172 LSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPE- 230
L+ G ++ + V EG + A+VRPPGHHAE + A GFCLF+NVAVAA+ +L P+
Sbjct: 128 LAAGSVVKLAEKVAEGELDCGFAIVRPPGHHAEADEAMGFCLFNNVAVAASFLLNERPDL 187
Query: 231 SVRKIMIVDWDIHHGNGTQKAFYDDDR--VLY----------------VSLHRYQLGKYY 272
V+KI+IVDWD+HHGNGTQK F+ D R Y L R++ G +Y
Sbjct: 188 GVKKILIVDWDVHHGNGTQKMFWKDPREPTFYSITPLLDFYAWKVTGNAFLVRHEYGGFY 247
Query: 273 PGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSG 332
P G+Y+ GEG GEGFN N+ W G GDA+Y+ A++ +++P+ REF PD++ +S+G
Sbjct: 248 PAGDDGDYNMVGEGPGEGFNINVPWDQGRCGDADYLAAWDHILIPVAREFNPDVIFLSAG 307
Query: 333 FDAADGDTIGQCHVTPACYGHMTH--------------------------MLLSLAKGNL 366
FDA G C VTP Y M LL+LA G +
Sbjct: 308 FDA------GGCCVTPYGYSVMLKKVGVEVNSLFCPSFVFALQGSPSLKIALLALA-GKI 360
Query: 367 CVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKKQPTPEAKKMIETVIRTQSKYW 424
+ LEGGYNLDSIAKS+L +VL+ + + P P+ P ++I+ V + YW
Sbjct: 361 VLALEGGYNLDSIAKSSLACVQVLLEDKQIQGP-PEAYPFESTWRVIQAVRKRLCTYW 417
>CE08062 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 796
Score = 221 bits (563), Expect = 3e-57
Identities = 138/381 (36%), Positives = 201/381 (52%), Gaps = 38/381 (9%)
Query: 54 TGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDL 113
TG+ YD M H + H E+ RI ++ L E+G +Q
Sbjct: 392 TGLGYDQAMVRHECCCGNNAS----HVENGGRIQSIWSKLIEHGHVQK------------ 435
Query: 114 MVKVPVREAEEEEILQVHSRQHLDFIS---------QTEQLERESLLKETEGGDSV---- 160
KV ++A E++ VHS+ + F + L + L+ GG V
Sbjct: 436 CEKVTAKKASLEQLQLVHSQTYTTFFAVSPTACLKIDANSLPLKRFLQLPCGGIGVDSDT 495
Query: 161 YFNNDS-YLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAV 219
YFN+ S +A+L+ G IE V EGR+KN A +RPPGHHAE E A GFC F+NVAV
Sbjct: 496 YFNDASTQTAARLAAGTLIELSSQVAEGRLKNGFACIRPPGHHAEHEQAMGFCFFNNVAV 555
Query: 220 AAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGN 279
A + YP KI I+DWD+HHGNGTQ +F +D VLY+SLHR+ G ++PGT G+
Sbjct: 556 AVKVLQTKYPAQCAKIAIIDWDVHHGNGTQLSFENDPNVLYMSLHRHDKGNFFPGT--GS 613
Query: 280 YDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADG- 338
+ G+ +G N+ + + D EY+ A+ VI P+ F PD +++S+GFDA G
Sbjct: 614 VTEVGKNDAKGLTVNVPFSGDVMRDPEYLAAWRTVIEPVMASFCPDFIIVSAGFDACHGH 673
Query: 339 -DTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPD- 396
+ +G VTP +G+MT LL+ A G + + LEGGY+L SI+++A + L+GE D
Sbjct: 674 PNALGGYEVTPEMFGYMTKSLLNYASGKVVLALEGGYDLKSISEAAQQCVQALIGESDDA 733
Query: 397 ---ELPAPKKQPTPEAKKMIE 414
A + P P A + ++
Sbjct: 734 GRLSSVALESLPNPSAVETLQ 754
>At5g61070 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 714
Score = 218 bits (556), Expect = 2e-56
Identities = 123/347 (35%), Positives = 186/347 (53%), Gaps = 54/347 (15%)
Query: 121 EAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGG-DSVYFNNDSYLSAKLSCGGAIE 179
+AE++ + VH+++H++ + +++S + DS+Y N S +A L+ G ++
Sbjct: 109 KAEDKHLKLVHTKKHVNLVKSISTKKKDSRRNKIASQLDSIYLNGGSSEAAYLAAGSVVK 168
Query: 180 ACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLK------------- 226
+ V EG + A+VRPPGHHAE + A GFCLF+NVAVAA+ +L
Sbjct: 169 VAEKVAEGELDCGFAIVRPPGHHAESDEAMGFCLFNNVAVAASFLLNERVMTSFDFCDAF 228
Query: 227 --SYPES---------------------------VRKIMIVDWDIHHGNGTQKAFYDDDR 257
SY S V+KI+IVDWDIHHGN T AF
Sbjct: 229 SISYLLSNFFGHIPLVRTFVLMLCGINRMQPDLDVKKILIVDWDIHHGNVTGNAF----- 283
Query: 258 VLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMP 317
+ R+ G +YP G+++ GEG GEGFN N+ W GG GDA+Y+ + +++P
Sbjct: 284 -----VTRHDHGSFYPFGDDGDFNMVGEGPGEGFNINVPWEQGGCGDADYLAVWNHILIP 338
Query: 318 MGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLD 377
+ +EF+PD++L+S+GFDAA GD +G C VTP Y M L+ A G + + LEGGYNL+
Sbjct: 339 VTKEFKPDIILLSAGFDAAIGDPLGGCCVTPYGYSVMLKKLMEFAHGKIVLALEGGYNLE 398
Query: 378 SIAKSALGVCKVLVGEPPDELPAPKKQPTPEAKKMIETVIRTQSKYW 424
S+ KS+L +VL+ E + + P +++I+ V YW
Sbjct: 399 SLGKSSLACVQVLL-EDKQIHGSSETYPLESTRRVIQAVRERLCTYW 444
>CE24411 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 517
Score = 197 bits (500), Expect = 6e-50
Identities = 127/373 (34%), Positives = 203/373 (54%), Gaps = 34/373 (9%)
Query: 53 KTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGD 112
K + +D + + H + + SY H E PRR+ + + L L+ DP +
Sbjct: 6 KVFVIFDHQEQRHDQPWPSY------HIEVPRRLDAILERLNTTKLLTDPRIE------- 52
Query: 113 LMVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKL 172
+P REAEE EIL VH+++++D + TE + E + +Y N+ ++ AKL
Sbjct: 53 ---HIPRREAEESEILAVHTKRYVDDVKSTETMTVEQQESFCTKYEDIYVNSATWHRAKL 109
Query: 173 SCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESV 232
+ G +I+ +V+ + + IA +RPPGHHA P+ GFC+F+NVA+AA K+ ++
Sbjct: 110 AAGASIDLMTSVMAAK-RPGIAFIRPPGHHAMPDEGCGFCIFNNVAIAA----KAAIQNG 164
Query: 233 RKIMIVDWDIHHGNGTQKAFYD--DDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEG 290
+K++IVD+D+H GNGTQ+ + V +S+HRY+ G ++P N QTG
Sbjct: 165 QKVLIVDYDVHAGNGTQECVEQMGEGNVQLISIHRYENGHFWP-----NMPQTGIYHNYK 219
Query: 291 FNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPAC 350
N+ T G+ DA+Y F +I+P F+PDL+L+SSGFDA+ GD G VTPA
Sbjct: 220 NTINLPLNTIGLTDADYHALFTHIILPTIHAFQPDLLLVSSGFDASIGDPEGSMQVTPAG 279
Query: 351 YGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKKQPTPEAK 410
+ M ML+ + +LEGGY LD++A + V + L+GE E+P + + A
Sbjct: 280 FATMIRMLIDTGI-PVAALLEGGYFLDALAADSEWVLRALLGE---EIPRIRVEKIHSA- 334
Query: 411 KMIETVIRTQSKY 423
+ +T+ R +Y
Sbjct: 335 -IADTIGRVVKRY 346
>At4g33470 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 359
Score = 171 bits (434), Expect = 3e-42
Identities = 112/336 (33%), Positives = 176/336 (52%), Gaps = 26/336 (7%)
Query: 69 FTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEIL 128
+T Y ++ + HPE R+ + L N L P G+ ++ + A E+I
Sbjct: 5 YTVYLQHWESHPECSARVPAIVNALEMNELT--PKFRGSQ----ILELANFKTATVEDIA 58
Query: 129 QVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGR 188
VH + ++ + + +S L EG Y + + + S G + +VV R
Sbjct: 59 NVHDKAYVFGLEKAMDEASDSGLIFIEGSGPTYATS-TVTALCSSAGAGMALVDSVVMSR 117
Query: 189 VK-NSI------AVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWD 241
+ NS+ A++RPPGHHA P+ GFC+F NVA+AA + +++ +++I I+D+D
Sbjct: 118 LTINSVDPPIGFALIRPPGHHAVPKGPMGFCVFGNVAIAARHAQRTH--GLKRIFIIDFD 175
Query: 242 IHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGG 301
+HHGNGT AF +D + ++S H+ YPGT G G+GKGEG N+ P GG
Sbjct: 176 VHHGNGTNDAFTEDPDIFFLSTHQ---DGSYPGT--GKISDIGKGKGEGTTLNLPLP-GG 229
Query: 302 VGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSL 361
GD FE++I+P + F+PD++L+S+G+DA D + T A Y + + L
Sbjct: 230 SGDIAMRTVFEEIIVPCAQRFKPDIILVSAGYDAHVLDPLANLQFTTATYYSLAKDIKRL 289
Query: 362 AK---GNLCV-VLEGGYNLDSIAKSALGVCKVLVGE 393
AK G CV LEGGYNL+S++ S + L+GE
Sbjct: 290 AKEVCGGRCVFFLEGGYNLESLSSSVADSFRALLGE 325
>CE20787 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 782
Score = 170 bits (431), Expect = 6e-42
Identities = 115/355 (32%), Positives = 185/355 (51%), Gaps = 37/355 (10%)
Query: 55 GICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLM 114
G YD RM H +Y E P+R+ +Y+ L + D L GA
Sbjct: 281 GYVYDERMLGHE------CKYDSTMAECPKRMKLIYERLQK-----DKLLDGA------- 322
Query: 115 VKVPVREAEEEEILQVHSRQHLDFISQTEQLER-ESLLKETEGGDSVYFNNDSYLSAKLS 173
VK+ REA + EI H +Q +D I E+ E K+ E ++ ++ +A+++
Sbjct: 323 VKIDAREANDSEIRLNHPQQLIDEIVSLNSTEKCEEYCKDKE---ILWTCENTNEAARVA 379
Query: 174 CGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVR 233
GG+IE KA +EG++ N A+VRPPGHH+ ++A G+C+F+NVA+AA ++ V+
Sbjct: 380 IGGSIELVKAAMEGKIHNGFAMVRPPGHHSYGKVAQGYCIFNNVAIAAKYAIEKL--EVK 437
Query: 234 KIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNC 293
K+ IVD+D H GNGT ++ D+ R+ S H + G ++P +YD + F
Sbjct: 438 KVAIVDFDYHAGNGTYQSVKDESRIHLTSFHGHHFGAFWP--FSRDYDYATNSQNTLF-- 493
Query: 294 NITWPTGGV--GDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTI---GQCHVTP 348
P G + +Y+ F V++PM +F+P+L+LIS+GFD+ D + GQ V
Sbjct: 494 ---VPLNGTMNSEGDYVSVFHHVLLPMLEQFQPELILISAGFDSGYYDVMMEFGQ-GVKA 549
Query: 349 ACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKK 403
YGHM +L + G + +LEGGY+ + +SA + + L+ P L P++
Sbjct: 550 HGYGHMARLLSQICPGKILAILEGGYHPYNYTESASMMVRGLLNLPLPRLDIPER 604
>SPAC3G9.07c [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 434
Score = 141 bits (356), Expect = 3e-33
Identities = 101/344 (29%), Positives = 166/344 (47%), Gaps = 28/344 (8%)
Query: 61 RMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVR 120
R+ YH + Y D HP P RI ++ GL + M R
Sbjct: 27 RVTYHLDEQVGNYHYGDKHPMKPHRITITNHLVMGYGL------------HNKMSVFSPR 74
Query: 121 EAEEEEILQVHSRQHLDFISQTEQLERESLLKETEG---GDSVYFNNDSYLSAKLSCGGA 177
A E+ + H +LDF+ + E + + GD + +Y ++ S G +
Sbjct: 75 MATFGEMSEFHREDYLDFLKRVTPDNAEQFADKFQQFNIGDDCPVFDGTYEFSQRSAGAS 134
Query: 178 IEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIM 236
++A + +V+G+ IA+ G HHA+ A GFC +++ +A NML+ +P +++
Sbjct: 135 LDASRKLVQGQT--DIAINWSGGLHHAKRGEASGFCYVNDIVLAILNMLRFFP----RVL 188
Query: 237 IVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNIT 296
+D DIHHG+G Q+AFY+ DRVL VS H+Y G ++P T GN+D+ G G+ F N+
Sbjct: 189 YIDIDIHHGDGVQQAFYESDRVLTVSFHKYN-GDFFPAT--GNFDENGVKGGKYFALNVP 245
Query: 297 WPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTH 356
G+GD +Y F+ +I P F+P +++ G D+ D +G +++ +G
Sbjct: 246 L-EDGIGDEQYTSLFKSIIEPTINTFQPSAIVLQCGADSLGYDRLGVFNLSIHAHGECVR 304
Query: 357 MLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEP-PDELP 399
S + VV GGY L ++A++ + V E P ELP
Sbjct: 305 FTRSF-NIPMLVVGGGGYTLRNVARAWCYETSICVNEQIPSELP 347
>At1g08460 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 377
Score = 138 bits (347), Expect = 3e-32
Identities = 92/336 (27%), Positives = 169/336 (49%), Gaps = 28/336 (8%)
Query: 72 YFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVH 131
+ + ++ HPE+ R+ + IL + P ++ + ++ E+L H
Sbjct: 32 FLDVLEKHPENADRVRNMLSILRRGPIA--PHVNWFTGLPAIV----------SELLMFH 79
Query: 132 SRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKN 191
+ ++++ + +E + + E + + S+ +A L+ G + A + +++ K
Sbjct: 80 TSEYIEKL-----VEADKSGERCEIAAGTFMSPGSWEAALLAAGTTLSAMQHILDCHGKI 134
Query: 192 SIAVVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKA 251
+ A+VRPPGHH++P A G+C +N A+A L S S ++ ++D D+H+GNGT +
Sbjct: 135 AYALVRPPGHHSQPTQADGYCFLNNAALAVKLALNS--GSCSRVAVIDIDVHYGNGTAEG 192
Query: 252 FYDDDRVLYVSLH--RYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMW 309
FY D+VL VSLH G +P G+ D+ GE G G+N N+ P G GD Y +
Sbjct: 193 FYTSDKVLTVSLHMNHGSWGSSHPQ--KGSIDELGEDVGLGYNLNVPLP-NGTGDRGYEY 249
Query: 310 AFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAK----GN 365
A ++++P R F PD+V++ G D++ D G+ +T Y + ++ +A+ G
Sbjct: 250 AMNELVVPAVRRFGPDMVVLVVGQDSSAFDPNGRQSLTMNGYRRIGQIMRGVAEEHSHGR 309
Query: 366 LCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAP 401
L +V EGGY++ A + + ++ P L P
Sbjct: 310 LLMVQEGGYHVTYAAYCLHAMLEGVLKIPEPHLSDP 345
>Hs17158041 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 879
Score = 132 bits (333), Expect = 1e-30
Identities = 86/240 (35%), Positives = 120/240 (49%), Gaps = 36/240 (15%)
Query: 54 TGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDL 113
TGI YD M H + + HPE RI ++ L E GL+
Sbjct: 633 TGIAYDPLMLKHQCVCGNS----TTHPEHAGRIQSIWSRLQETGLLNK------------ 676
Query: 114 MVKVPVREAEEEEILQVHSRQHLDFISQT----EQLERESLLKETE---------GG--- 157
++ R+A EEI VHS H ++L+ LL + GG
Sbjct: 677 CERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGV 736
Query: 158 --DSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPGHHAEPEIAGGFCLFS 215
D+++ S +A+++ G IE V G +KN AVVRPPGHHAE A GFC F+
Sbjct: 737 DSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFN 796
Query: 216 NVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGT 275
+VA+ A + ++ KI+IVD D+HHGNGTQ+AFY D +LY+SLHRY G ++PG+
Sbjct: 797 SVAITAKYLRDQL--NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGS 854
>YGL194c [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 452
Score = 132 bits (331), Expect = 2e-30
Identities = 95/344 (27%), Positives = 166/344 (47%), Gaps = 30/344 (8%)
Query: 44 KPKIRYSLLKTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPT 103
K K L + Y R+ YH S++ Y HP P R+ +++ GL +
Sbjct: 10 KTKENEPLFEFNSAYSPRVSYHFNSKVSHYHYGVKHPMKPFRLMLTDHLVSSYGLHK--- 66
Query: 104 LSGADSIGDLMVKVPVREAEEEEILQVHSRQHLDFISQTE-----QLERESLLKETEGGD 158
+M R A +E+LQ HS +++F+S+ +L R +L G D
Sbjct: 67 ---------IMDLYETRSATRDELLQFHSEDYVNFLSKVSPENANKLPRGTLENFNIGDD 117
Query: 159 SVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNV 217
F N Y L G +++A + ++ + + IA+ G HHA+ GFC +++
Sbjct: 118 CPIFQN-LYDYTTLYTGASLDATRKLINNQ--SDIAINWSGGLHHAKKNSPSGFCYVNDI 174
Query: 218 AVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIH 277
++ N+L+ +P +I+ +D D+HHG+G Q+AFY DRV +S H+Y G+++PGT
Sbjct: 175 VLSILNLLRYHP----RILYIDIDLHHGDGVQEAFYTTDRVFTLSFHKYN-GEFFPGT-- 227
Query: 278 GNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAAD 337
G+ + G KG+ F N+ G+ D Y+ F+ ++ P+ F+P L++ G D+
Sbjct: 228 GDLTEIGCDKGKHFALNVPL-EDGIDDDSYINLFKSIVDPLIMTFKPTLIVQQCGADSLG 286
Query: 338 GDTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAK 381
D +G ++ +G + S L VV GGY ++++
Sbjct: 287 HDRLGCFNLNIKAHGECVKFVKSFGLPML-VVGGGGYTPRNVSR 329
>YNL330c [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 433
Score = 128 bits (321), Expect = 3e-29
Identities = 91/328 (27%), Positives = 161/328 (48%), Gaps = 32/328 (9%)
Query: 61 RMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVR 120
R+ Y + Y HP P RI + ++ GL + + A +
Sbjct: 20 RVAYFYDADVGNYAYGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRA------------K 67
Query: 121 EAEEEEILQVHSRQHLDFISQT-----EQLERESLLKETEGGDSVYFNNDSYLSAKLSCG 175
A ++E+ Q H+ +++DF+S+ E +RES+ K G D F+ Y +S G
Sbjct: 68 PATKQEMCQFHTDEYIDFLSRVTPDNLEMFKRESV-KFNVGDDCPVFDG-LYEYCSISGG 125
Query: 176 GAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRK 234
G++E + G K +AV G HHA+ A GFC +++ + +L+ +P +
Sbjct: 126 GSMEGAARLNRG--KCDVAVNYAGGLHHAKKSEASGFCYLNDIVLGIIELLRYHP----R 179
Query: 235 IMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCN 294
++ +D D+HHG+G ++AFY DRV+ S H+Y G+++PGT G G G G+ + N
Sbjct: 180 VLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKY--GEFFPGT--GELRDIGVGAGKNYAVN 235
Query: 295 ITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHM 354
+ G+ DA Y FE VI + ++P V++ G D+ GD +G +++ + +
Sbjct: 236 VPL-RDGIDDATYRSVFEPVIKKIMEWYQPSAVVLQCGGDSLSGDRLGCFNLSMEGHANC 294
Query: 355 THMLLSLAKGNLCVVLEGGYNLDSIAKS 382
+ + S + VV GGY + ++A++
Sbjct: 295 VNYVKSFGI-PMMVVGGGGYTMRNVART 321
>CE18116 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 465
Score = 127 bits (320), Expect = 4e-29
Identities = 101/354 (28%), Positives = 170/354 (47%), Gaps = 49/354 (13%)
Query: 65 HAKIFTSY--------FEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVK 116
H+K SY F Y HP P R+ + ++ GL + L V
Sbjct: 5 HSKSRVSYYYDGDFGNFYYGQGHPMKPHRVRMTHSLIVNYGLYRK-----------LNVM 53
Query: 117 VPVREAEEEEILQVHSRQHLDFISQ---------TEQLERESLLKETEGGDSVYFNNDSY 167
P R A EI + HS +++F+ T+Q+ R S+ G D F+ Y
Sbjct: 54 RPAR-ASFSEITRYHSDDYINFLRNVKSDNMSTFTDQMARFSV-----GEDCPVFDG-MY 106
Query: 168 LSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLK 226
+LSCGG++ A + R ++ IA+ G HHA+ A GFC +++ +A +LK
Sbjct: 107 EFCQLSCGGSLAAAARL--NRQESEIAINWMGGLHHAKKSEASGFCYSNDIVLAILELLK 164
Query: 227 SYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEG 286
+ ++++ +D D+HHG+G ++AFY DRV+ VS H++ G+Y+PGT G+ G G
Sbjct: 165 HH----KRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKH--GEYFPGT--GDLKDVGAG 216
Query: 287 KGEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHV 346
G+ + N+ GV D Y F ++ + F+P+ V++ G D+ GD +G ++
Sbjct: 217 SGKYYALNVPL-RDGVDDVTYERIFRTIMGEVMARFQPEAVVLQCGADSLAGDRLGVFNL 275
Query: 347 TPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVG-EPPDELP 399
T +G + S L +V GGY + ++++ L + + E D+LP
Sbjct: 276 TTYGHGKCVEYMKSF-NVPLLLVGGGGYTIRNVSRCWLYETAIALNQEVSDDLP 328
>SPBC36.05c [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 405
Score = 125 bits (315), Expect = 2e-28
Identities = 93/330 (28%), Positives = 162/330 (48%), Gaps = 30/330 (9%)
Query: 73 FEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHS 132
+ Y HP P R+ V+ ++ L + L V PVR A ++ + H+
Sbjct: 19 YHYGPQHPMKPHRVRMVHNLVVNYNLYEK-----------LNVITPVR-ATRNDMTRCHT 66
Query: 133 RQHLDFI----SQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGR 188
++++F+ T + + LK G D F+ Y +S GG+I A + + G
Sbjct: 67 DEYIEFLWRVTPDTMEKFQPHQLKFNVGDDCPVFDG-LYEFCSISAGGSIGAAQELNSGN 125
Query: 189 VKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNG 247
+ IA+ G HHA+ A GFC +++A+AA +LK + ++++ +D D+HHG+G
Sbjct: 126 AE--IAINWAGGLHHAKKREASGFCYVNDIALAALELLKYH----QRVLYIDIDVHHGDG 179
Query: 248 TQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEY 307
++ FY DRV+ S H++ G+Y+PGT G+ TG G G+ + N+ G+ D Y
Sbjct: 180 VEEFFYTTDRVMTCSFHKF--GEYFPGT--GHIKDTGIGTGKNYAVNVPL-RDGIDDESY 234
Query: 308 MWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLC 367
F+ VI + + F P+ V++ G D+ GD +G +++ + + S +C
Sbjct: 235 ESVFKPVISHIMQWFRPEAVILQCGTDSLAGDRLGCFNLSMKGHSMCVDFVKSFNLPMIC 294
Query: 368 VVLEGGYNLDSIAKSALGVCKVLVGEPPDE 397
V GGY + ++A+ +L GE DE
Sbjct: 295 VG-GGGYTVRNVARVWTYETGLLAGEELDE 323
>ECU03g1370 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 416
Score = 124 bits (310), Expect = 6e-28
Identities = 91/334 (27%), Positives = 161/334 (47%), Gaps = 33/334 (9%)
Query: 73 FEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHS 132
F Y HP P R+ + +L L + M + +A E + H+
Sbjct: 17 FSYAMGHPMKPLRVKMTHTLLVGYELYK------------YMDVLRPFQASYENLTNFHA 64
Query: 133 RQHLDFISQTEQLERESLLKETEG---GDSVYFNNDSYLSAKLSCGGAIEACKAVVEGRV 189
+++F+S E ++K+ D Y +L+ GG+I A + + G
Sbjct: 65 VDYINFLSSVSSENMEEMIKDLHKFNIRDDCPVFPGLYDYCRLTSGGSIYAAQKINSG-- 122
Query: 190 KNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGT 248
K +A+ G HHA+ A GFC +++ + +LK ++I+ +D DIHHG+G
Sbjct: 123 KYDVAINWAGGLHHAKRGEASGFCYVNDIVLGILELLKYN----KRILYIDIDIHHGDGV 178
Query: 249 QKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYM 308
++AFY DRV+ VS H+Y G Y+PGT G TG KG+G++ N+ G+ D Y
Sbjct: 179 EEAFYTTDRVMTVSFHKY--GDYFPGT--GMVTDTGLAKGKGYSVNVPL-KDGIDDESYF 233
Query: 309 WAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLCV 368
F+ ++ + ++P+ +++ SG D+ GD +G +++ + + S N+ +
Sbjct: 234 SIFKPIVSKVIETYQPNAIVLQSGADSLSGDKLGCFNLSHLGHSRCIKFVQSF---NIPL 290
Query: 369 VL--EGGYNLDSIAKS-ALGVCKVLVGEPPDELP 399
+L GGY + +++K+ A G VL + P E+P
Sbjct: 291 ILLGGGGYTIGNVSKAWAYGTSVVLDVDIPREIP 324
>Hs20551695 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 488
Score = 119 bits (299), Expect = 1e-26
Identities = 98/355 (27%), Positives = 167/355 (46%), Gaps = 41/355 (11%)
Query: 53 KTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGD 112
K +CY Y+ +Y+ Y HP P RI + +L GL +
Sbjct: 9 KKKVCY-----YYDGDIGNYY-YGQGHPMKPHRIRMTHNLLLNYGLYRK----------- 51
Query: 113 LMVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETE----GGDSVYFNNDSYL 168
M +A EE+ + HS +++ F+ K+ + G D F+ +
Sbjct: 52 -MEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDG-LFE 109
Query: 169 SAKLSCGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKS 227
+LS GG++ AV R + +AV G HHA+ A GFC +++ +A +LK
Sbjct: 110 FCQLSTGGSVAG--AVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKY 167
Query: 228 YPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGK 287
+ ++++ +D DIHHG+G ++AFY DRV+ VS H+Y G+Y+PGT G+ G GK
Sbjct: 168 H----QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGK 219
Query: 288 GEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVT 347
G+ + N G+ D Y F+ +I + ++P V++ G D+ GD +G ++T
Sbjct: 220 GKYYAVNFPM-RDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLT 278
Query: 348 PACYGHMTHMLLSLAKGNLCVVL--EGGYNLDSIAKS-ALGVCKVLVGEPPDELP 399
+ ++ + NL +++ GGY + ++A+ L E P+ELP
Sbjct: 279 VKGHAKCVEVVKTF---NLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELP 330
>Hs13128860 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 482
Score = 119 bits (297), Expect = 2e-26
Identities = 95/335 (28%), Positives = 158/335 (46%), Gaps = 35/335 (10%)
Query: 73 FEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHS 132
+ Y HP P RI + +L GL + M +A EE+ + HS
Sbjct: 22 YYYGQGHPMKPHRIRMTHNLLLNYGLYRK------------MEIYRPHKANAEEMTKYHS 69
Query: 133 RQHLDFISQTEQLERESLLKETE----GGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGR 188
++ F+ K+ + G D F+ + +LS GG++ + AV +
Sbjct: 70 DDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDG-LFEFCQLSTGGSVAS--AVKLNK 126
Query: 189 VKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNG 247
+ IAV G HHA+ A GFC +++ +A +LK + ++++ +D DIHHG+G
Sbjct: 127 QQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDG 182
Query: 248 TQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEY 307
++AFY DRV+ VS H+Y G+Y+PGT G+ G GKG+ + N G+ D Y
Sbjct: 183 VEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGKGKYYAVNYPL-RDGIDDESY 237
Query: 308 MWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLC 367
F+ V+ + F+P V++ G D+ GD +G ++T + + S NL
Sbjct: 238 EAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSF---NLP 294
Query: 368 VVL--EGGYNLDSIAKS-ALGVCKVLVGEPPDELP 399
+++ GGY + ++A+ L E P+ELP
Sbjct: 295 MLMLGGGGYTIRNVARCWTYETAVALDTEIPNELP 329
>CE08952 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 461
Score = 118 bits (296), Expect = 3e-26
Identities = 95/345 (27%), Positives = 165/345 (47%), Gaps = 31/345 (8%)
Query: 61 RMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVR 120
R+ Y+ + Y H P RI + ++ GL ++ L + P
Sbjct: 14 RVAYYYDSNIGNYYYGQGHVMKPHRIRMTHHLVLNYGLYRN-----------LEIFRPF- 61
Query: 121 EAEEEEILQVHSRQHLDFISQTEQLERES----LLKETEGGDSVYFNNDSYLSAKLSCGG 176
A E++ + HS +++ F+ +S +LK G D F+ Y +LS GG
Sbjct: 62 PASFEDMTRFHSDEYMTFLKSANPDNLKSFNKQMLKFNVGEDCPLFDG-LYEFCQLSSGG 120
Query: 177 AIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKI 235
++ A + + +V IA+ G HHA+ A GFC +++ + +LK + +++
Sbjct: 121 SLAAATKLNKQKV--DIAINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYH----KRV 174
Query: 236 MIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNI 295
+ VD D+HHG+G ++AFY DRV+ VS H+Y G ++PGT G+ G GKG+ ++ N+
Sbjct: 175 LYVDIDVHHGDGVEEAFYTTDRVMTVSFHKY--GDFFPGT--GDLKDIGAGKGKLYSVNV 230
Query: 296 TWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMT 355
G+ D Y F+ ++ + F+P V++ G D+ +GD +G ++T +G
Sbjct: 231 PL-RDGITDVSYQSIFKPIMTKVMERFDPCAVVLQCGADSLNGDRLGPFNLTLKGHGECA 289
Query: 356 HMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVG-EPPDELP 399
S L +V GGY ++A+ + V E P+ELP
Sbjct: 290 RFFRSY-NVPLMMVGGGGYTPRNVARCWTYETSIAVDKEVPNELP 333
>Hs4557641 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 488
Score = 117 bits (294), Expect = 5e-26
Identities = 98/355 (27%), Positives = 166/355 (46%), Gaps = 41/355 (11%)
Query: 53 KTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGD 112
K +CY Y+ +Y+ Y HP P RI + +L GL +
Sbjct: 9 KKKVCY-----YYDGDIGNYY-YGQGHPMKPHRIRMTHNLLLNYGLYRK----------- 51
Query: 113 LMVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETE----GGDSVYFNNDSYL 168
M +A EE+ + HS +++ F+ K+ G D F+ +
Sbjct: 52 -MEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMHIFNVGEDCPAFDG-LFE 109
Query: 169 SAKLSCGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKS 227
+LS GG++ AV R + +AV G HHA+ A GFC +++ +A +LK
Sbjct: 110 FCQLSTGGSVAG--AVKLNRQQTDMAVNWAGGLHHAKKYEASGFCYVNDIVLAILELLKY 167
Query: 228 YPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGK 287
+ ++++ +D DIHHG+G ++AFY DRV+ VS H+Y G+Y+PGT G+ G GK
Sbjct: 168 H----QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGK 219
Query: 288 GEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVT 347
G+ + N G+ D Y F+ +I + ++P V++ G D+ GD +G ++T
Sbjct: 220 GKYYAVNFPM-CDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLT 278
Query: 348 PACYGHMTHMLLSLAKGNLCVVL--EGGYNLDSIAKS-ALGVCKVLVGEPPDELP 399
+ ++ + NL +++ GGY + ++A+ L E P+ELP
Sbjct: 279 VKGHAKCVEVVKTF---NLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELP 330
>7292522 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 521
Score = 114 bits (286), Expect = 4e-25
Identities = 93/336 (27%), Positives = 158/336 (46%), Gaps = 40/336 (11%)
Query: 53 KTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGD 112
K +CY Y+ +Y+ Y HP P RI + +L GL +
Sbjct: 6 KKRVCY-----YYDSDIGNYY-YGQGHPMKPHRIRMTHNLLLNYGLYRK----------- 48
Query: 113 LMVKVPVREAEEEEILQVHSRQHLDFISQTEQLERESLLKETE----GGDSVYFNNDSYL 168
M +A +E+ + HS +++ F+ K+ + G D F+ Y
Sbjct: 49 -MEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDG-LYE 106
Query: 169 SAKLSCGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKS 227
+LS GG++ A AV + + I + G HHA+ A GFC +++ + +LK
Sbjct: 107 FCQLSAGGSVAA--AVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKY 164
Query: 228 YPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGK 287
+ ++++ +D D+HHG+G ++AFY DRV+ VS H+Y G+Y+PGT G+ G GK
Sbjct: 165 H----QRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGK 216
Query: 288 GEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVT 347
G+ + NI G+ D Y F +I + F+P V++ G D+ GD +G ++T
Sbjct: 217 GKYYAVNIPL-RDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLT 275
Query: 348 PACYGHMTHMLLSLAKGNL--CVVLEGGYNLDSIAK 381
+G + K NL +V GGY + ++++
Sbjct: 276 VKGHGKCVEF---VKKYNLPFLMVGGGGYTIRNVSR 308
>CE01472 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 507
Score = 112 bits (279), Expect = 3e-24
Identities = 94/353 (26%), Positives = 163/353 (45%), Gaps = 44/353 (12%)
Query: 59 DVRMRYHAKIFTSYFEYIDPHPEDPRRIYRV------YKILAENGLIQDPTLSGADSIGD 112
+V YH + +F Y HP P+R+ Y++ +++ P L AD
Sbjct: 30 NVAYYYHKDV--GHFHYGQLHPMKPQRLVVCNDLVVSYEMPKYMTVVESPKLDAAD---- 83
Query: 113 LMVKVPVREAEEEEILQVHSRQHLDFISQ-TEQLER---ESLLKETEGGDSVYFNNDSYL 168
I H+ +++F+ T +L + +L++ G+ +
Sbjct: 84 --------------ISVFHTEDYVNFLQTVTPKLGLTMPDDVLRQFNIGEDCPIFAGLWD 129
Query: 169 SAKLSCGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKS 227
L GG++E + + N I + P G HHA+ A GFC +++ + +LK
Sbjct: 130 YCTLYAGGSVEGARRL--NHKMNDIVINWPGGLHHAKKSEASGFCYVNDIVLGILELLKY 187
Query: 228 YPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGK 287
+ ++++ +D DIHHG+G Q+AF + DRV+ VS HR+ G+Y+PG+ G+ G G
Sbjct: 188 H----KRVLYIDIDIHHGDGVQEAFNNSDRVMTVSFHRF--GQYFPGS--GSIMDKGVGP 239
Query: 288 GEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVT 347
G+ F N+ + D Y+ FE VI + F P+ +++ G D+ D +GQ ++
Sbjct: 240 GKYFAINVPL-MAAIRDEPYLKLFESVISGVEENFNPEAIVLQCGSDSLCEDRLGQFALS 298
Query: 348 PACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKS-ALGVCKVLVGEPPDELP 399
+ + SL K L V+ GGY L ++A+ AL +L DE+P
Sbjct: 299 FNAHARAVKYVKSLGK-PLMVLGGGGYTLRNVARCWALETGVILGLRMDDEIP 350
>At5g63110 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 471
Score = 111 bits (278), Expect = 3e-24
Identities = 94/352 (26%), Positives = 162/352 (45%), Gaps = 43/352 (12%)
Query: 61 RMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGL-----IQDPTLSGADSIGDLMV 115
R+ Y + + Y HP P RI + ++ L I P+L+ A IG
Sbjct: 20 RVSYFYEPTIGDYYYGQGHPMKPHRIRMAHSLIIHYHLHRRLEISRPSLADASDIG---- 75
Query: 116 KVPVREAEEEEILQVHSRQHLDFI------SQTEQLERESLLKETEGGDSVYFNNDSYLS 169
+ HS +++DF+ S + +L + G D F+ +
Sbjct: 76 -------------RFHSPEYVDFLASVSPESMGDPSAARNLRRFNVGEDCPVFDG-LFDF 121
Query: 170 AKLSCGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSY 228
+ S GG+I A AV R IA+ G HHA+ A GFC +++ + +LK +
Sbjct: 122 CRASAGGSIGA--AVKLNRQDADIAINWGGGLHHAKKSEASGFCYVNDIVLGILELLKMF 179
Query: 229 PESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKG 288
++++ +D D+HHG+G ++AFY DRV+ VS H++ G ++PGT G+ G KG
Sbjct: 180 ----KRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKF--GDFFPGT--GHIRDVGAEKG 231
Query: 289 EGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTP 348
+ + N+ G+ D + F +I + ++P+ V++ G D+ GD +G +++
Sbjct: 232 KYYALNVPL-NDGMDDESFRSLFRPLIQKVMEVYQPEAVVLQCGADSLSGDRLGCFNLSV 290
Query: 349 ACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVG-EPPDELP 399
+ L S L V+ GGY + ++A+ V VG EP ++LP
Sbjct: 291 KGHADCLRFLRSY-NVPLMVLGGGGYTIRNVARCWCYETAVAVGVEPDNKLP 341
>At4g38130 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 501
Score = 111 bits (278), Expect = 3e-24
Identities = 94/354 (26%), Positives = 165/354 (46%), Gaps = 37/354 (10%)
Query: 52 LKTGICYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIG 111
+K +CY Y ++ Y Y HP P RI + +LA GL+Q
Sbjct: 15 VKRKVCYF----YDPEVGNYY--YGQGHPMKPHRIRMTHALLAHYGLLQH---------- 58
Query: 112 DLMVKVPVREAEEEEILQVHSRQHLDFIS----QTEQLERESLLKETEGGDSVYFNNDSY 167
+ V P A + ++ + H+ ++ F+ +T+Q + L + G D F+ Y
Sbjct: 59 -MQVLKPF-PARDRDLCRFHADDYVSFLRSITPETQQDQIRQLKRFNVGEDCPVFDG-LY 115
Query: 168 LSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLK 226
+ GG++ + G IA+ G HHA+ A GFC +++ +A +LK
Sbjct: 116 SFCQTYAGGSVGGSVKLNHGLC--DIAINWAGGLHHAKKCEASGFCYVNDIVLAILELLK 173
Query: 227 SYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEG 286
+ +++ VD DIHHG+G ++AFY DRV+ VS H++ G Y+PGT G+ G G
Sbjct: 174 QH----ERVLYVDIDIHHGDGVEEAFYATDRVMTVSFHKF--GDYFPGT--GHIQDIGYG 225
Query: 287 KGEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHV 346
G+ ++ N+ G+ D Y F+ ++ + F P V++ G D+ GD +G ++
Sbjct: 226 SGKYYSLNVPL-DDGIDDESYHLLFKPIMGKVMEIFRPGAVVLQCGADSLSGDRLGCFNL 284
Query: 347 TPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVG-EPPDELP 399
+ + + S L ++ GGY + ++A+ V +G E D++P
Sbjct: 285 SIKGHAECVKFMRSF-NVPLLLLGGGGYTIRNVARCWCYETGVALGVEVEDKMP 337
>Hs13128862 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 428
Score = 101 bits (252), Expect = 3e-21
Identities = 88/339 (25%), Positives = 150/339 (43%), Gaps = 42/339 (12%)
Query: 73 FEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHS 132
F Y HP P R+ + ++ GL + M+ +A + ++ + HS
Sbjct: 16 FHYGAGHPMKPHRLALTHSLVLHYGLYKK------------MIVFKPYQASQHDMCRFHS 63
Query: 133 RQHLDFISQTEQLERESLLKETE----GGDSVYFNN-----DSYLSAKLSCGGAIEACKA 183
++DF+ + + K G D F Y A L GA +
Sbjct: 64 EDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQ--GATQLNNK 121
Query: 184 VVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDI 242
+ + IA+ G HHA+ A GFC +++ + +LK +P +++ +D DI
Sbjct: 122 ICD------IAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHP----RVLYIDIDI 171
Query: 243 HHGNGTQKAFYDDDRVLYVSLHRYQLGKY-YPGTIHGNYDQTGEGKGEGFNCNITWPTGG 301
HHG+G Q+AFY DRV+ VS H+Y G Y +PGT G+ + G G + N+ G
Sbjct: 172 HHGDGVQEAFYLTDRVMTVSFHKY--GNYFFPGT--GDMYEVGAESGRYYCLNVPL-RDG 226
Query: 302 VGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSL 361
+ D Y F+ VI + ++P +++ G D+ D +G +++ +G + S
Sbjct: 227 IDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSF 286
Query: 362 AKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEP-PDELP 399
L V+ GGY + ++A+ +LV E +ELP
Sbjct: 287 -NIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELP 324
>ECU09g0670 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 344
Score = 100 bits (250), Expect = 6e-21
Identities = 65/201 (32%), Positives = 104/201 (51%), Gaps = 15/201 (7%)
Query: 201 HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLY 260
HHA I GFC +++ +A +LK+Y R++M +D D+HHG+G ++AF + DRVL
Sbjct: 113 HHAHKAIPSGFCHVNDIVLAILELLKTY----RRVMYIDIDVHHGDGVEEAFLECDRVLT 168
Query: 261 VSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGR 320
+SLH+Y G ++P T G TG N + G+ D Y + FE ++ R
Sbjct: 169 LSLHKYGDG-FFPET--GTLITTGH---RAVNVPL---LSGIDDPSYRYIFEPIVESCVR 219
Query: 321 EFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIA 380
F PD +++ G D+ D +G +++ + + SL LC+ GGY L ++A
Sbjct: 220 RFSPDAIVLQCGADSLGEDRLGCFNLSIEGHASCVRFVSSLGIPLLCLG-GGGYTLTNVA 278
Query: 381 KSALGVCKVLVGE-PPDELPA 400
+ VL GE P E+P+
Sbjct: 279 RCWAYETAVLCGEDPATEIPS 299
>7296744 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 438
Score = 100 bits (250), Expect = 6e-21
Identities = 89/357 (24%), Positives = 159/357 (43%), Gaps = 44/357 (12%)
Query: 59 DVRMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVP 118
D R+ Y F Y HP P+R+ + ++ GL + + + P
Sbjct: 3 DRRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKK-----------MKIYRP 51
Query: 119 VREAEEEEILQVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSC---G 175
+ A +++L+ HS +++ ++ Q + + Y ++ S C
Sbjct: 52 YK-ASAQDMLRFHSDEYIAYLQQVTP-------QNIQCNSVAYTKYLAHFSVGEDCPVFD 103
Query: 176 GAIEACK----AVVEGRVK-----NSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANML 225
G + C A +EG K + I + G HHA+ A GFC +++ + +L
Sbjct: 104 GLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGFCYVNDIVIGILELL 163
Query: 226 KSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKY-YPGTIHGNYDQTG 284
K +P +++ +D D+HHG+G Q+AFY DRV+ S H+Y G Y +PGT G+ + G
Sbjct: 164 KYHP----RVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKY--GNYFFPGT--GDMYEIG 215
Query: 285 EGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQC 344
G ++ N+ G+ D Y F+ +I + + P +++ G D+ GD +G
Sbjct: 216 AESGRYYSVNVPLKE-GIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCF 274
Query: 345 HVTPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEP-PDELPA 400
++ +G + L L VV GGY L ++A+ +LV + ++LPA
Sbjct: 275 SLSTKGHGECVKFVKELNVPTL-VVGGGGYTLRNVARCWTHETSLLVDQDIENDLPA 330
>Hs8923769 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 377
Score = 99.8 bits (247), Expect = 1e-20
Identities = 77/281 (27%), Positives = 134/281 (47%), Gaps = 16/281 (5%)
Query: 117 VPVREAEEEEILQVHSR---QHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLS 173
V + A EE+ H+ QHL +SQ + ++ G D +A +
Sbjct: 57 VKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIG 116
Query: 174 CGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESV 232
G I A + +++G K +A+ G HHA+ + A GFC ++ + + + +
Sbjct: 117 -GATITAAQCLIDGMCK--VAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKF---- 169
Query: 233 RKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFN 292
+I+ VD D+HHG+G + AF +V+ VSLH++ G ++PGT G+ G GKG ++
Sbjct: 170 ERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGT--GDVSDVGLGKGRYYS 226
Query: 293 CNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYG 352
N+ G+ D +Y E V+ + + F P V++ G D GD + ++TP G
Sbjct: 227 VNVP-IQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIG 285
Query: 353 HMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGE 393
+L L ++ GGYNL + A+ + V++G+
Sbjct: 286 KCLKYILQWQLATL-ILGGGGYNLANTARCWTYLTGVILGK 325
>At3g44680 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 419
Score = 96.3 bits (238), Expect = 1e-19
Identities = 87/337 (25%), Positives = 160/337 (46%), Gaps = 45/337 (13%)
Query: 75 YIDP-HPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHSR 133
Y P HP P R+ + ++ GL M +A E+ Q HS
Sbjct: 16 YFGPNHPMKPHRLCMTHHLILAYGLHSK------------MEVYRPHKAYPIEMAQFHSP 63
Query: 134 QHLDFIS----QTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGRV 189
+++F+ + + L + + G D F D + +L GG I+A + R+
Sbjct: 64 DYVEFLQRINPENQNLFPNEMARYNLGEDCPVFE-DLFEFCQLYAGGTIDAAR-----RL 117
Query: 190 KNS---IAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHG 245
N IA+ G HHA+ A GFC +++ + +LK +P +++ +D D+HHG
Sbjct: 118 NNKLCDIAINWAGGLHHAKKCDASGFCYINDLVLGILELLKHHP----RVLYIDIDVHHG 173
Query: 246 NGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDA 305
+G ++AFY DRV+ VS H++ K++PGT G+ + GE +G+ + N+ G+ D+
Sbjct: 174 DGVEEAFYFTDRVMTVSFHKFG-DKFFPGT--GDVKEIGEREGKFYAINVPL-KDGIDDS 229
Query: 306 EYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGN 365
+ F V+ ++P +++ G D+ D +G ++ + GH + + K N
Sbjct: 230 SFNRLFRTVV----EIYQPGAIVLQCGADSLARDRLGCFNL--SIDGH-AECVKFVKKFN 282
Query: 366 LCVVLE--GGYNLDSIAKSALGVCKVLVG-EPPDELP 399
L +++ GGY +++A+ +L+ E P+E+P
Sbjct: 283 LPLLVTGGGGYTKENVARCWTVETGILLDTELPNEIP 319
>Hs13376228 [B] KOG1344 Predicted histone deacetylase
Length = 347
Score = 89.7 bits (221), Expect = 1e-17
Identities = 77/299 (25%), Positives = 129/299 (42%), Gaps = 32/299 (10%)
Query: 79 HPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHSRQHLDF 138
HP D + +V L E L+ D L V REA EE++L VH+R++L+
Sbjct: 35 HPFDAGKWGKVINFLKEEKLLSDSML------------VEAREASEEDLLVVHTRRYLNE 82
Query: 139 ISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSIAVVRP 198
+ + + + + + + GG I A K VE + V
Sbjct: 83 LKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVE---RGWAINVGG 139
Query: 199 PGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRV 258
HH + GGFC ++++ +A + + E + + I+D D H GNG ++ F DD RV
Sbjct: 140 GFHHCSSDRGGGFCAYADITLAIKFLFERV-EGISRATIIDLDAHQGNGHERDFMDDKRV 198
Query: 259 LYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFEQVIMPM 318
+ ++ + YPG Q K E + W G D EY+ E+ I
Sbjct: 199 YIMDVYNRHI---YPGDRFAK--QAIRRKVE-----LEW---GTEDDEYLDKVERNIKKS 245
Query: 319 GREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKGN---LCVVLEGGY 374
+E PD+V+ ++G D +GD +G ++PA ++ + +G + +V GGY
Sbjct: 246 LQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGY 304
>At5g35600 [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 409
Score = 79.7 bits (195), Expect = 1e-14
Identities = 85/354 (24%), Positives = 157/354 (44%), Gaps = 47/354 (13%)
Query: 61 RMRYHAKIFTSYFEYIDPHPEDPRRIYRVYKILAENGLIQDPTLSGADSIGDLMVKVPVR 120
R+ Y + + Y P P+RI + ++ L + ++ D
Sbjct: 11 RVSYFYEPMIGDYYYGVNQPTKPQRIRVTHNLILSYNLHRHMEINHPDL----------- 59
Query: 121 EAEEEEILQVHSRQHLDFI-------------SQTEQLERESLLKETEGGDSVYFNNDSY 167
A+ + + HS ++++F+ S +E L+R ++ + +G V+ N Y
Sbjct: 60 -ADASDFEKFHSLEYINFLKSVTPETVTDPHPSVSENLKRFNVDVDWDG--PVFHNLFDY 116
Query: 168 LSAKLSCGGAIEACKAVVEGRVKNSIAVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLK 226
A GG+I A + R + IA+ G HH + + A GF ++V +A +LK
Sbjct: 117 CRAY--AGGSISAAAKL--NRQEADIAINWAGGMHHVKKDKASGFGYVNDVVLAILELLK 172
Query: 227 SYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEG 286
S+ ++++ ++ HG+ ++AF D DRV+ VS H+ +G G+ GEG
Sbjct: 173 SF----KRVLYIEIGFPHGDEVEEAFKDTDRVMTVSFHK--VGD------TGDISDYGEG 220
Query: 287 KGEGFNCNITWPTGGVGDAEYMWAFEQVIMPMGREFEPDLVLISSGFDAADGDTIGQCHV 346
KG+ ++ N G+ D F VI +EP+++++ G D+ GD G ++
Sbjct: 221 KGQYYSLNAPL-KDGLDDFSLRGLFIPVIHRAMEIYEPEVIVLQCGADSLAGDPFGTFNL 279
Query: 347 TPACYGHMTHMLLSLAKGNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPD-ELP 399
+ +G + S L ++ GGY L ++A+ + VGE D +LP
Sbjct: 280 SIKGHGDCLQYVRSF-NVPLMILGGGGYTLPNVARCWCYETAIAVGEQLDNDLP 332
>YPR068c [B] KOG1342 Histone deacetylase complex catalytic component RPD3
Length = 470
Score = 70.1 bits (170), Expect = 1e-11
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 13/177 (7%)
Query: 201 HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAFYDDDRVLY 260
HHA + A GFC ++V + + K+ + KI VD+D+HHG+G +KAF ++
Sbjct: 210 HHAFKQRASGFCYINDVVLLIQRLRKA---KLNKITYVDFDLHHGDGVEKAFQYSKQIQT 266
Query: 261 VSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAF-EQVIMPMG 319
+S+H Y+ G ++PGT G+ + + K + P D Y+ +++ P+
Sbjct: 267 ISVHLYEPG-FFPGT--GSLSDSRKDKNV-----VNIPLKHGCDDNYLELIASKIVNPLI 318
Query: 320 REFEPDLVLISSGFDAADGDTIGQCHVTPACYGH-MTHMLLSLAKGNLCVVLEGGYN 375
EP+ ++I G D GD + +T + +++ S + ++ ++ GGYN
Sbjct: 319 ERHEPEALIIECGGDGLLGDRFNEWQLTIRGLSRIIINIMKSYPRAHIFLLGGGGYN 375
>YPL116w [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 697
Score = 63.5 bits (153), Expect = 1e-09
Identities = 90/374 (24%), Positives = 144/374 (38%), Gaps = 75/374 (20%)
Query: 127 ILQVHSRQHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKL--SCGGAIEACKAV 184
+L+VH + + Q+ LLK + + D YLS+K + G I A +
Sbjct: 110 VLKVHGSSWPAELIELCQMADAKLLKGEIEVPDTWNSGDIYLSSKTIKALQGTIGAIETG 169
Query: 185 VEGRVKNSIA---------VVRPPGHHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKI 235
V+ K A +RPPGHH GFCL +N VA +Y +V +
Sbjct: 170 VDSIFKGPSAEHISNRAFVAIRPPGHHCHYGTPSGFCLLNNAHVAIEYAYDTY--NVTHV 227
Query: 236 MIVDWDIHHGNGTQ------------------------KAFYDDDRVLYVSLHRYQLGKY 271
+++D+D+HHG+GTQ K F + +V Y S+H
Sbjct: 228 VVLDFDLHHGDGTQDICWKRAGFKPEEEPEDSSYDDFGKKFAEFPKVGYFSMHDINSFPT 287
Query: 272 YPG-TIHGNYDQTGEGKGEGFNCNI------TWPTGGVGDAEYMWAFEQV---------- 314
G N + NI W T + Y + +
Sbjct: 288 ESGFATKENIKNASTCIMNSHDLNIWNIHLSKWTTEEEFNVLYRTKYRTLFAKADEFFRS 347
Query: 315 ----IMPMGREFEPDLVLISSGFDAADGD-TIGQCH---VTPACYGHMTHMLLSLAK--- 363
+ GR F+ LV+IS+GFDA++ + T Q H V + Y T L LA+
Sbjct: 348 AKLEMNQQGRPFK-GLVVISAGFDASEFEQTSMQRHSVNVPTSFYTTFTKDALKLAQMHC 406
Query: 364 -GNLCVVLEGGYNLDSIAKSALGVCKVLVGEPPDELPAPKKQPTPEAKKMIETVIRTQSK 422
G + ++EGGY+ +I GV L+G L ++++++ ++R
Sbjct: 407 HGKVLSLMEGGYSDKAICS---GVFAHLIG-----LQNQDWVKEWGSEQVVKEIVRGCKP 458
Query: 423 YWSCFKNRHGNDGI 436
W +K + D I
Sbjct: 459 AWKPYKTKRAKDVI 472
>7301219 [B] KOG1344 Predicted histone deacetylase
Length = 343
Score = 62.0 bits (149), Expect = 3e-09
Identities = 64/305 (20%), Positives = 124/305 (39%), Gaps = 43/305 (14%)
Query: 79 HPEDPRRIYRVYKILA-----ENGLIQDPTLSGADSIGDLMVKVPVREAEEEEILQVHSR 133
HP D + ++K+L ++G +PT E ++++ ++H+R
Sbjct: 51 HPFDAAKGKHIHKLLCAQLQLDDGSFYEPT-----------------ELTKDQLRRIHTR 93
Query: 134 QHLDFISQTEQLERESLLKETEGGDSVYFNNDSYLSAKLSCGGAIEACKAVVEGRVKNSI 193
++L + + + + + + Y + G+I A K ++
Sbjct: 94 EYLKSLRWSMNVACIAEVPLMAFVPNRYIQRSYLRPMRFQAAGSILAGKLALD----YGW 149
Query: 194 AVVRPPG-HHAEPEIAGGFCLFSNVAVAAANMLKSYPESVRKIMIVDWDIHHGNGTQKAF 252
A+ G HH GGFC ++++++ + + P VR+IMIVD D H GNG ++ F
Sbjct: 150 AINLGGGFHHCCSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDF 209
Query: 253 YDDDRVLYVSLHRYQLGKYYPGTIHGNYDQTGEGKGEGFNCNITWPTGGVGDAEYMWAFE 312
+ V V + YP D + E C + D Y+ +
Sbjct: 210 ---NNVAAVYIFDMYNAFVYP------RDHVAK---ESIRCAVEL-RNYTEDGFYLRQLK 256
Query: 313 QVIMPMGREFEPDLVLISSGFDAADGDTIGQCHVTPACYGHMTHMLLSLAKG---NLCVV 369
+ +M EF PD+V+ ++G D +GD +G ++ ++ S + + ++
Sbjct: 257 RCLMQSLAEFRPDMVVYNAGTDVLEGDPLGNLAISAEGVIERDRLVFSTFRALGIPVVML 316
Query: 370 LEGGY 374
L GGY
Sbjct: 317 LSGGY 321
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,559,679
Number of Sequences: 60738
Number of extensions: 2171185
Number of successful extensions: 5558
Number of sequences better than 1.0e-05: 47
Number of HSP's better than 0.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 5355
Number of HSP's gapped (non-prelim): 66
length of query: 704
length of database: 30,389,216
effective HSP length: 113
effective length of query: 591
effective length of database: 23,525,822
effective search space: 13903760802
effective search space used: 13903760802
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)