ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV2501 check: MH Q KOG1209 Secondary metabolites biosynthesis, transport and catabolism 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV2501 873694 872891 -268
(268 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductas... 125 6e-29
SPAC977.08 [Q] KOG1205 Predicted dehydrogenase 124 2e-28
SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase 124 2e-28
Hs20149619 [Q] KOG1205 Predicted dehydrogenase 117 2e-26
Hs7706318 [Q] KOG1205 Predicted dehydrogenase 112 4e-25
Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase 112 4e-25
7301818 [Q] KOG1205 Predicted dehydrogenase 110 3e-24
Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 105 5e-23
Hs7657478 [Q] KOG1205 Predicted dehydrogenase 104 1e-22
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 102 7e-22
At3g03330 [Q] KOG1205 Predicted dehydrogenase 98 1e-20
Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 97 3e-20
SPCC162.03 [Q] KOG1205 Predicted dehydrogenase 96 5e-20
7290108 [R] KOG0725 Reductases with broad range of substrate spe... 96 7e-20
Hs7705907 [R] KOG0725 Reductases with broad range of substrate s... 95 9e-20
HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 95 1e-19
YMR226c [Q] KOG1205 Predicted dehydrogenase 94 2e-19
Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 93 4e-19
Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 92 6e-19
7296047 [Q] KOG1205 Predicted dehydrogenase 92 6e-19
YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase ... 92 1e-18
Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 91 1e-18
CE27259 [R] KOG0725 Reductases with broad range of substrate spe... 91 1e-18
SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reduct... 91 2e-18
Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 91 2e-18
CE27260 [R] KOG0725 Reductases with broad range of substrate spe... 91 2e-18
At1g10310 [R] KOG0725 Reductases with broad range of substrate s... 90 4e-18
CE21095 [R] KOG0725 Reductases with broad range of substrate spe... 89 8e-18
Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and... 88 1e-17
Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 88 1e-17
Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 88 1e-17
CE07544 [Q] KOG1205 Predicted dehydrogenase 88 1e-17
CE03132 [R] KOG0725 Reductases with broad range of substrate spe... 88 1e-17
7296705 [R] KOG0725 Reductases with broad range of substrate spe... 87 2e-17
At3g55310 [R] KOG0725 Reductases with broad range of substrate s... 86 7e-17
At1g63380 [R] KOG0725 Reductases with broad range of substrate s... 86 7e-17
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 84 2e-16
Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 84 3e-16
CE03954 [R] KOG0725 Reductases with broad range of substrate spe... 84 3e-16
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 83 4e-16
At1g62610 [R] KOG0725 Reductases with broad range of substrate s... 83 4e-16
YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 82 6e-16
CE03951 [R] KOG0725 Reductases with broad range of substrate spe... 82 6e-16
CE06649 [R] KOG0725 Reductases with broad range of substrate spe... 82 1e-15
At3g47360 [Q] KOG1205 Predicted dehydrogenase 82 1e-15
CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 81 2e-15
At1g52340 [R] KOG0725 Reductases with broad range of substrate s... 80 2e-15
SPCC24B10.20 [R] KOG1611 Predicted short chain-type dehydrogenase 80 3e-15
Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 80 3e-15
Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 80 3e-15
CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 80 3e-15
7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 80 3e-15
Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 80 4e-15
At3g47350 [Q] KOG1205 Predicted dehydrogenase 80 4e-15
At3g46170 [R] KOG0725 Reductases with broad range of substrate s... 80 4e-15
At1g54870 [R] KOG0725 Reductases with broad range of substrate s... 79 7e-15
7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 79 7e-15
7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase 79 9e-15
7295487 [R] KOG0725 Reductases with broad range of substrate spe... 79 9e-15
7292613 [Q] KOG1205 Predicted dehydrogenase 79 9e-15
SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase 78 1e-14
Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase 78 1e-14
CE21093 [R] KOG0725 Reductases with broad range of substrate spe... 78 1e-14
CE07539 [Q] KOG1205 Predicted dehydrogenase 78 1e-14
At3g42960 [R] KOG0725 Reductases with broad range of substrate s... 78 1e-14
At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 78 1e-14
SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase 77 2e-14
CE12990 [R] KOG0725 Reductases with broad range of substrate spe... 77 2e-14
7300831 [Q] KOG1205 Predicted dehydrogenase 77 2e-14
CE19894 [R] KOG0725 Reductases with broad range of substrate spe... 77 3e-14
CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 77 3e-14
CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 76 4e-14
CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 76 6e-14
CE12594 [R] KOG0725 Reductases with broad range of substrate spe... 75 7e-14
CE21092 [R] KOG0725 Reductases with broad range of substrate spe... 75 1e-13
CE14538 [R] KOG0725 Reductases with broad range of substrate spe... 75 1e-13
At5g50590 [Q] KOG1205 Predicted dehydrogenase 75 1e-13
YIR035c [Q] KOG1204 Predicted dehydrogenase 75 1e-13
Hs10337605 [R] KOG0725 Reductases with broad range of substrate ... 75 1e-13
At5g50700 [Q] KOG1205 Predicted dehydrogenase 75 1e-13
At5g50600 [Q] KOG1205 Predicted dehydrogenase 75 1e-13
7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 75 1e-13
7296706_2 [R] KOG0725 Reductases with broad range of substrate s... 75 1e-13
SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase 74 2e-13
CE05726 [R] KOG0725 Reductases with broad range of substrate spe... 74 2e-13
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 74 2e-13
At5g50690 [Q] KOG1205 Predicted dehydrogenase 74 2e-13
7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 74 2e-13
7295621 [Q] KOG1205 Predicted dehydrogenase 74 2e-13
At2g29260 [R] KOG0725 Reductases with broad range of substrate s... 73 4e-13
7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 73 4e-13
7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 73 4e-13
At5g61830 [Q] KOG1208 Dehydrogenases with different specificitie... 73 5e-13
At2g30670 [R] KOG0725 Reductases with broad range of substrate s... 72 6e-13
7296704 [R] KOG0725 Reductases with broad range of substrate spe... 72 6e-13
SPAC922.06 [R] KOG0725 Reductases with broad range of substrate ... 72 8e-13
Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 72 1e-12
Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 72 1e-12
At3g29260 [R] KOG0725 Reductases with broad range of substrate s... 72 1e-12
7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 71 1e-12
CE26808_2 [R] KOG0725 Reductases with broad range of substrate s... 71 1e-12
Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 70 2e-12
7297069 [Q] KOG1205 Predicted dehydrogenase 70 2e-12
YIR036c [Q] KOG1204 Predicted dehydrogenase 70 3e-12
CE20725 [R] KOG0725 Reductases with broad range of substrate spe... 70 3e-12
7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 70 3e-12
7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 70 3e-12
Hs5031737 [R] KOG0725 Reductases with broad range of substrate s... 70 4e-12
At3g29250 [R] KOG0725 Reductases with broad range of substrate s... 70 4e-12
At2g47120 [R] KOG0725 Reductases with broad range of substrate s... 70 4e-12
SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase 69 5e-12
Hs20373187 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 69 5e-12
At3g26770 [R] KOG0725 Reductases with broad range of substrate s... 69 7e-12
At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase a... 69 7e-12
CE13008 [R] KOG0725 Reductases with broad range of substrate spe... 69 9e-12
At4g10020 [Q] KOG1205 Predicted dehydrogenase 69 9e-12
7294452 [Q] KOG1205 Predicted dehydrogenase 69 9e-12
SPAC8E11.10 [R] KOG0725 Reductases with broad range of substrate... 68 1e-11
CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 68 1e-11
7290988 [Q] KOG1205 Predicted dehydrogenase 68 1e-11
Hs19923817 [R] KOG0725 Reductases with broad range of substrate ... 68 2e-11
CE15574 [R] KOG0725 Reductases with broad range of substrate spe... 68 2e-11
At5g51030 [Q] KOG1208 Dehydrogenases with different specificitie... 68 2e-11
At5g06060 [R] KOG0725 Reductases with broad range of substrate s... 68 2e-11
At3g51680 [R] KOG0725 Reductases with broad range of substrate s... 68 2e-11
Hs7705925 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 67 2e-11
CE09969 [R] KOG0725 Reductases with broad range of substrate spe... 67 2e-11
At3g26760 [R] KOG0725 Reductases with broad range of substrate s... 67 2e-11
At2g47130 [R] KOG0725 Reductases with broad range of substrate s... 67 2e-11
YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 67 3e-11
At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase 67 3e-11
At3g61220 [Q] KOG1208 Dehydrogenases with different specificitie... 67 3e-11
Hs4502601 [Q] KOG1208 Dehydrogenases with different specificitie... 66 4e-11
CE08181 [Q] KOG1208 Dehydrogenases with different specificities ... 66 4e-11
7300731 [Q] KOG1205 Predicted dehydrogenase 66 4e-11
7292690 [Q] KOG1205 Predicted dehydrogenase 66 4e-11
7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 66 4e-11
CE11498 [R] KOG0725 Reductases with broad range of substrate spe... 66 6e-11
SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate ... 65 8e-11
CE02786 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 65 8e-11
7302393 [Q] KOG1208 Dehydrogenases with different specificities ... 65 8e-11
CE13054 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 65 1e-10
At2g24190 [Q] KOG1208 Dehydrogenases with different specificitie... 65 1e-10
Hs20070272 [Q] KOG1208 Dehydrogenases with different specificiti... 65 1e-10
CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 65 1e-10
CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 65 1e-10
At1g07440 [R] KOG0725 Reductases with broad range of substrate s... 65 1e-10
Hs4502599 [Q] KOG1208 Dehydrogenases with different specificitie... 64 2e-10
Hs18582884 [Q] KOG1208 Dehydrogenases with different specificiti... 64 2e-10
CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 64 2e-10
CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase 64 2e-10
7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 64 2e-10
CE02490_1 [R] KOG0725 Reductases with broad range of substrate s... 64 2e-10
At2g29320 [R] KOG0725 Reductases with broad range of substrate s... 64 3e-10
YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 63 4e-10
SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 63 4e-10
CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 63 5e-10
At2g29310 [R] KOG0725 Reductases with broad range of substrate s... 63 5e-10
7295622 [Q] KOG1205 Predicted dehydrogenase 63 5e-10
7294121 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 63 5e-10
Hs20558355 [Q] KOG1205 Predicted dehydrogenase 62 6e-10
At3g05260 [R] KOG0725 Reductases with broad range of substrate s... 62 6e-10
At2g29300 [R] KOG0725 Reductases with broad range of substrate s... 62 6e-10
At1g01800 [Q] KOG1208 Dehydrogenases with different specificitie... 62 8e-10
7301617_1 [R] KOG0725 Reductases with broad range of substrate s... 62 8e-10
Hs4759084 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 62 1e-09
Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 62 1e-09
CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 62 1e-09
CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 62 1e-09
7300387 [Q] KOG1208 Dehydrogenases with different specificities ... 62 1e-09
SPCC736.13 [Q] KOG1208 Dehydrogenases with different specificiti... 61 1e-09
CE05801 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 61 1e-09
CE05427 [R] KOG0725 Reductases with broad range of substrate spe... 61 1e-09
7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 61 1e-09
Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydrox... 61 2e-09
CE09505 [R] KOG1611 Predicted short chain-type dehydrogenase 61 2e-09
SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate ... 60 2e-09
Hs10047132 [R] KOG0725 Reductases with broad range of substrate ... 60 2e-09
At5g50770 [Q] KOG1205 Predicted dehydrogenase 60 2e-09
At3g59710 [Q] KOG1208 Dehydrogenases with different specificitie... 60 3e-09
At4g03140 [R] KOG0725 Reductases with broad range of substrate s... 60 4e-09
At2g47140 [R] KOG0725 Reductases with broad range of substrate s... 59 5e-09
At2g29340 [R] KOG0725 Reductases with broad range of substrate s... 59 5e-09
CE28758 [R] KOG0725 Reductases with broad range of substrate spe... 59 7e-09
At2g29360 [R] KOG0725 Reductases with broad range of substrate s... 59 7e-09
At2g29170 [R] KOG0725 Reductases with broad range of substrate s... 59 7e-09
CE21514 [R] KOG0725 Reductases with broad range of substrate spe... 59 9e-09
CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 59 9e-09
CE04339 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 59 9e-09
At2g29350 [R] KOG0725 Reductases with broad range of substrate s... 59 9e-09
At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP... 59 9e-09
YBR159w [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 58 1e-08
SPCC1739.08c [R] KOG0725 Reductases with broad range of substrat... 58 2e-08
CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 58 2e-08
Hs13236542 [Q] KOG1205 Predicted dehydrogenase 57 2e-08
CE25799 [R] KOG1611 Predicted short chain-type dehydrogenase 57 2e-08
Hs4503301 [R] KOG0725 Reductases with broad range of substrate s... 57 4e-08
CE10908 [R] KOG0725 Reductases with broad range of substrate spe... 57 4e-08
At5g04900 [R] KOG0725 Reductases with broad range of substrate s... 57 4e-08
At3g04000 [R] KOG0725 Reductases with broad range of substrate s... 57 4e-08
7293189 [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 56 5e-08
At2g29330 [R] KOG0725 Reductases with broad range of substrate s... 56 6e-08
ECU08g1150 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 55 8e-08
7290912 [R] KOG1611 Predicted short chain-type dehydrogenase 55 8e-08
7297912 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 55 1e-07
YOR246c [Q] KOG1208 Dehydrogenases with different specificities ... 55 1e-07
SPBC16H5.14c [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 55 1e-07
Hs5031765 [Q] KOG1205 Predicted dehydrogenase 55 1e-07
At2g37540 [Q] KOG1208 Dehydrogenases with different specificitie... 54 2e-07
CE05118 [R] KOG0725 Reductases with broad range of substrate spe... 54 2e-07
At4g05530 [R] KOG0725 Reductases with broad range of substrate s... 54 3e-07
CE02315 [R] KOG0725 Reductases with broad range of substrate spe... 53 4e-07
Hs19923983 [R] KOG0725 Reductases with broad range of substrate ... 53 5e-07
Hs19923931 [Q] KOG1208 Dehydrogenases with different specificiti... 53 5e-07
At2g29150 [R] KOG0725 Reductases with broad range of substrate s... 53 5e-07
7297516 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 53 5e-07
At2g29290 [R] KOG0725 Reductases with broad range of substrate s... 52 7e-07
YKL071w [R] KOG1611 Predicted short chain-type dehydrogenase 51 1e-06
SPAC22A12.17c [R] KOG0725 Reductases with broad range of substra... 51 1e-06
Hs10190704 [R] KOG0725 Reductases with broad range of substrate ... 51 1e-06
At5g50130 [Q] KOG1208 Dehydrogenases with different specificitie... 51 1e-06
At2g29370 [R] KOG0725 Reductases with broad range of substrate s... 51 1e-06
7290022 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 51 2e-06
At4g13180 [R] KOG0725 Reductases with broad range of substrate s... 50 3e-06
Hs10190746 [Q] KOG1208 Dehydrogenases with different specificiti... 50 3e-06
CE02370 [R] KOG0725 Reductases with broad range of substrate spe... 50 3e-06
7290386 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 50 3e-06
CE28036 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 50 4e-06
At3g03980 [R] KOG0725 Reductases with broad range of substrate s... 50 4e-06
7290709 [Q] KOG1208 Dehydrogenases with different specificities ... 50 4e-06
7298168 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 49 1e-05
>At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 299
Score = 125 bits (314), Expect = 6e-29
Identities = 84/280 (30%), Positives = 139/280 (49%), Gaps = 28/280 (10%)
Query: 5 VILITGASTG-IGLSIAETLRSAGYEVFGTSR-KGSIPGKEYSFKMI--KLDITDEESVK 60
V+LITG S G IG ++A G V TSR + ++ E ++ +LD+ +++V
Sbjct: 9 VVLITGCSQGGIGHALAREFTEKGCRVVATSRSRSTMTDLEQDSRLFVKELDVQSDQNVS 68
Query: 61 SAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH----------- 109
++EVI+K G+IDVLVNNAG+ E + + T F TN FG
Sbjct: 69 KVLSEVIDKFGKIDVLVNNAGVQCVGPLAETPISAMENT-FNTNVFGNKDLIFSFNYYIY 127
Query: 110 ---------RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLD 160
RMT+AV+PHM ++ GKI+N+ S+ + P P+ +Y ++K A+ T++L
Sbjct: 128 WSFNSSGSMRMTQAVVPHMVSKKKGKIVNVGSITVMAPGPWAGVYTATKAAIHALTDTLR 187
Query: 161 YEVKKFGIHVSTIDPHIIKTGMANSNSPADE---EMAVYDSIKGKVSERMLKQSLENSDE 217
E++ FGI V + P I+T +ANS E+ +Y + + ER N
Sbjct: 188 LELRPFGIDVINVVPGGIRTNIANSAVATFNKMPELKLYKPYEEAIRERAFISQRMNPTP 247
Query: 218 PEVIAKEVLKVIKTENPKSRYTPGKAKLYAYFSYYTPSWI 257
E A++ + + +NP + ++ G+ Y+ P W+
Sbjct: 248 AETFARDTVAAVLKKNPPAWFSSGRYSTLMAVMYHMPLWL 287
>SPAC977.08 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 124 bits (310), Expect = 2e-28
Identities = 69/192 (35%), Positives = 112/192 (57%), Gaps = 3/192 (1%)
Query: 50 KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
+LD+ + S+K +V + I GRIDVL+NNAG + ++ +E + + IF TN FG
Sbjct: 20 QLDVNNFSSIKKSVEKAISHFGRIDVLLNNAGYSV-YSPLESTTEEQIHNIFNTNVFGAL 78
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
+ +A+ P R Q +G IIN+SS+GG M P G LY +K+A+EG +E+L +E++ G+
Sbjct: 79 EVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIGVK 138
Query: 170 VSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVI 229
V I+P T A + A YD++K K+ E +L + L+ + P+ IA+ +L+
Sbjct: 139 VKIIEPGFTATEF-RVEEGAGKHYAEYDNLKQKLYEDLLPK-LKTATPPQKIAEVILQAA 196
Query: 230 KTENPKSRYTPG 241
E+ + RY G
Sbjct: 197 TDESDELRYPTG 208
>SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 124 bits (310), Expect = 2e-28
Identities = 69/192 (35%), Positives = 112/192 (57%), Gaps = 3/192 (1%)
Query: 50 KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
+LD+ + S+K +V + I GRIDVL+NNAG + ++ +E + + IF TN FG
Sbjct: 20 QLDVNNFSSIKKSVEKAISHFGRIDVLLNNAGYSV-YSPLESTTEEQIHNIFNTNVFGAL 78
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
+ +A+ P R Q +G IIN+SS+GG M P G LY +K+A+EG +E+L +E++ G+
Sbjct: 79 EVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIGVK 138
Query: 170 VSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVI 229
V I+P T A + A YD++K K+ E +L + L+ + P+ IA+ +L+
Sbjct: 139 VKIIEPGFTATEF-RVEEGAGKHYAEYDNLKQKLYEDLLPK-LKTATPPQKIAEVILQAA 196
Query: 230 KTENPKSRYTPG 241
E+ + RY G
Sbjct: 197 TDESDELRYPTG 208
>Hs20149619 [Q] KOG1205 Predicted dehydrogenase
Length = 325
Score = 117 bits (293), Expect = 2e-26
Identities = 66/204 (32%), Positives = 119/204 (57%), Gaps = 15/204 (7%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKG------------SIPGKEYSFK- 47
++ V++ITGA++G+G A+ +AG ++ R G S K + K
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
Query: 48 -MIKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFF 106
++ D+TD ++ +A E+++ G +D+LVNNAGI+++ + + + D+ K + ETN+F
Sbjct: 110 YLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYR-GTIMDTTVDVDKRVMETNYF 168
Query: 107 GVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKF 166
G +T+A+LP M ++R G I+ ISS+ G M IP+ + Y +SKHA + + + L E++++
Sbjct: 169 GPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQY 228
Query: 167 GIHVSTIDPHIIKTGMANSNSPAD 190
I V+ I P I T ++ + AD
Sbjct: 229 EIEVTVISPGYIHTNLSVNAITAD 252
>Hs7706318 [Q] KOG1205 Predicted dehydrogenase
Length = 339
Score = 112 bits (281), Expect = 4e-25
Identities = 70/202 (34%), Positives = 116/202 (56%), Gaps = 19/202 (9%)
Query: 5 VILITGASTGIGLSIAETLRSAGYEVFGTSRK--------------GSIPGKEYSFKMIK 50
V+ +TGAS+GIG +A L G + ++R+ G++ KE ++
Sbjct: 52 VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNL--KEKDILVLP 109
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHR 110
LD+TD S ++A V+++ GRID+LVNN G++ + ++ S D+ + + E N+ G
Sbjct: 110 LDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDT-SLDVYRKLIELNYLGTVS 168
Query: 111 MTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKF-GIH 169
+T+ VLPHM E++ GKI+ ++S+ GI+ +P YC+SKHAL G+ L E+ + GI
Sbjct: 169 LTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGII 228
Query: 170 VSTIDPHIIKTGMANSNSPADE 191
VS I P +++ + NS A E
Sbjct: 229 VSNICPGPVQSNIV-ENSLAGE 249
>Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase
Length = 244
Score = 112 bits (281), Expect = 4e-25
Identities = 71/207 (34%), Positives = 111/207 (53%), Gaps = 17/207 (8%)
Query: 1 MKKQVILITGASTGIGLSIAETLRS---AGYEVFGTSRKGSIPGKEY-----------SF 46
M + V+LITG S+GIGL +A L S ++V+ T R G+ + S
Sbjct: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60
Query: 47 KMIKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFF 106
+ ++LD+ D +SV +A V E GR+DVLV NAG+ +E D ++ + N
Sbjct: 61 ETLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLL-GPLEALGEDAVASVLDVNVV 117
Query: 107 GVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKF 166
G RM +A LP M+ + G+++ S+GG+M +P+ +YC+SK ALEG ESL + F
Sbjct: 118 GTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPF 177
Query: 167 GIHVSTIDPHIIKTGMANSNSPADEEM 193
G+H+S I+ + T + EE+
Sbjct: 178 GVHLSLIECGPVHTAFMEKVLGSPEEV 204
>7301818 [Q] KOG1205 Predicted dehydrogenase
Length = 326
Score = 110 bits (274), Expect = 3e-24
Identities = 79/267 (29%), Positives = 131/267 (48%), Gaps = 24/267 (8%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGK------------EYSFKMIKL 51
+V+LITGAS+G+G S+A AG V +R+ + Y ++ L
Sbjct: 54 KVVLITGASSGLGESLAHVFYRAGCRVILAARRTQELERVKKDLLALDVDPAYPPTVLPL 113
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
D+ + S+ V V+ ++D+L+NN GI+ + A V + D+ + N+FG +
Sbjct: 114 DLAELNSIPEFVTRVLAVYNQVDILINNGGISVR-ADVASTAVDVDLKVMVVNYFGSVAL 172
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVS 171
T+A+LP M ++ G I ISS+ G IP A Y +SKHA++ + +SL EV I+VS
Sbjct: 173 TKALLPSMVKRGSGHICFISSVQGKFAIPQRAAYSASKHAMQAFADSLRAEVANKNINVS 232
Query: 172 TIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVIKT 231
+ P I+T ++ + + S GKV E K P+ +A+ +L+ I
Sbjct: 233 CVSPGYIRTQLSLN------ALTGSGSSYGKVDETTAK-----GMSPDKLAERILQCILR 281
Query: 232 ENPKSRYTPGKAKLYAYFSYYTPSWIF 258
+ P + +AK+ Y + PS F
Sbjct: 282 KEPDIIVSDVQAKIAYYLRHLCPSLYF 308
>Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 319
Score = 105 bits (263), Expect = 5e-23
Identities = 77/261 (29%), Positives = 138/261 (52%), Gaps = 22/261 (8%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGT--SRKGSIPGKEYSFKMIK---LDITDEESVK 60
I ITG +G G A T G+ V + GS K + + ++ LD+TD E+VK
Sbjct: 32 IFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVK 91
Query: 61 SAVNEVIEKAGRIDV--LVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPH 118
V + G + L+NNAG+ A + + + + E N FG+ +T +LP
Sbjct: 92 RTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPL 151
Query: 119 MREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHII 178
+++ + G++IN+SS+GG + I G Y SK+A+EG+ +SL ++K FG+HVS I+P +
Sbjct: 152 VKKAQ-GRVINVSSVGGRLAIVGGG-YTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLF 209
Query: 179 KTGMANSNSPADEEMAVYD----SIKGKVSERMLKQSLEN-SDEPEVIAKEVLKVIKTEN 233
KT +A+ ++++A+++ IK + E +++SL+ + ++ V++ +
Sbjct: 210 KTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMD 269
Query: 234 -------PKSRYTPGK-AKLY 246
PK+ Y GK AK++
Sbjct: 270 HALTSLFPKTHYAAGKDAKIF 290
>Hs7657478 [Q] KOG1205 Predicted dehydrogenase
Length = 311
Score = 104 bits (259), Expect = 1e-22
Identities = 76/258 (29%), Positives = 128/258 (49%), Gaps = 33/258 (12%)
Query: 4 QVILITGASTGIGLSIAETLR---SAGYEVFGTSRK-----------GSIPGKEYSFKMI 49
+ +LI+G S+GIGL +A L Y+V T R G G+ + +
Sbjct: 6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQ--TLTVA 63
Query: 50 KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
+LD+ +ESV ++ + G +DVLVNNAG+ +E S + +F+TNFFG
Sbjct: 64 QLDVCSDESVAQCLSCI---QGEVDVLVNNAGMGLV-GPLEGLSLAAMQNVFDTNFFGAV 119
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
R+ +AVLP M+ +R G I+ ISS+ G+ + + +Y +SK ALEG+ ESL ++ +F I
Sbjct: 120 RLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIF 179
Query: 170 VSTIDPHIIKT----------GMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPE 219
+S ++P + T MA E + + + S ++ +N P+
Sbjct: 180 ISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQN---PQ 236
Query: 220 VIAKEVLKVIKTENPKSR 237
+ + ++ VI + P R
Sbjct: 237 DVVQAIVNVISSTRPPLR 254
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 102 bits (253), Expect = 7e-22
Identities = 67/201 (33%), Positives = 107/201 (52%), Gaps = 10/201 (4%)
Query: 4 QVILITGASTGIGLSIA-ETLRSAGYEVFGTSRKGSIPGK---------EYSFKMIKLDI 53
+ ILITGAS+GIG S A E + A ++ +R+ S + E S +KLD+
Sbjct: 7 KTILITGASSGIGKSTAFEIAKVAKVKLILAARRFSTVEEIAKELESKYEVSVLPLKLDV 66
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
+D +S+ + + ++ IDVL+NNAG+A V + + D A T+ TN G+ MTR
Sbjct: 67 SDLKSIPGVIESLPKEFADIDVLINNAGLALGTDKVIDLNIDDAVTMITTNVLGMMAMTR 126
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
AVLP + G I+N+ S+ G G++YCS+K AL +T +L E I + +
Sbjct: 127 AVLPIFYSKNKGDILNVGSIAGRESYVGGSVYCSTKSALAQFTSALRKETIDTRIRIMEV 186
Query: 174 DPHIIKTGMANSNSPADEEMA 194
DP +++T + D++ A
Sbjct: 187 DPGLVETEFSVVRFHGDKQKA 207
>At3g03330 [Q] KOG1205 Predicted dehydrogenase
Length = 345
Score = 98.2 bits (243), Expect = 1e-20
Identities = 67/201 (33%), Positives = 102/201 (50%), Gaps = 13/201 (6%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIPGK--EYSFKMIKLDI 53
+V+ ITGAS GIG +A+ S ++ ++R K + GK K++ LD+
Sbjct: 44 KVVWITGASRGIGEILAKQFASLDAKLILSARNKAELDRVKSELKGKFAPEDVKVLPLDL 103
Query: 54 TD-EESVKSAVNEVIE--KAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHR 110
EES+K V + + +D LV+NA + + S + KT F+ N FG
Sbjct: 104 ASGEESLKHVVEQAVSLFPGAGVDYLVHNAAFERPKSKASDASEETLKTTFDVNVFGTIS 163
Query: 111 MTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV 170
+T+ V PHM +Q G + ISS G +P P A+Y +SKHAL GY SL E + GI V
Sbjct: 164 LTKLVAPHMLKQGGGHFVVISSAAGKVPSPGQAIYSASKHALHGYFHSLRSEFCQKGIKV 223
Query: 171 STIDPHIIKTGMANSNSPADE 191
+ + P I+T S +++
Sbjct: 224 TVVCPGPIETWNGTGTSTSED 244
>Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 387
Score = 96.7 bits (239), Expect = 3e-20
Identities = 79/282 (28%), Positives = 141/282 (49%), Gaps = 30/282 (10%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEY-------SFKMIKLDITD 55
++ +L+TG G+G ++ + L G+ VF + PG E ++++DIT
Sbjct: 82 QKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITK 141
Query: 56 EESVKSAVNEV---IEKAGRIDVLVNNAGI-AFKWAAVEECSTDLAKTIFETNFFGVHRM 111
+K A ++V ++ G + ++NNAG+ F TD K NFFG +
Sbjct: 142 PVQIKDAYSKVAAMLQDRG-LWAVINNAGVLGFPTDGELLLMTDY-KQCMAVNFFGTVEV 199
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVS 171
T+ LP +R+ + G+++N+SSMGG P+ A Y SSK A+ ++ + E+ K+GI V+
Sbjct: 200 TKTFLPLLRKSK-GRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVA 258
Query: 172 TIDPHIIKTGMANSNSPADE-EMAVYDSIKGKVSE-------------RMLKQSLENSDE 217
+I P T +A ++ ++ E + D + +V E +L SL + D
Sbjct: 259 SIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDF 318
Query: 218 PEVIAKEVLKVIKTENPKSRYTPGK-AKLYAYFSYYTPSWIF 258
V+ +++ I ++P + YTPGK A L+ ++Y P I+
Sbjct: 319 SPVL-RDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIY 359
>SPCC162.03 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 95.9 bits (237), Expect = 5e-20
Identities = 71/249 (28%), Positives = 129/249 (51%), Gaps = 17/249 (6%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKM-IKLDITDEESVKSAVN 64
+LITG+S G+G ++ + + GY V SR E+S + +KLD+TD +SV++A
Sbjct: 8 VLITGSSKGLGYALVKVGLAQGYNVIACSRAPDTITIEHSKLLKLKLDVTDVKSVETAFK 67
Query: 65 EVIEKAGRIDVLVNNAGIA----FKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPHMR 120
+ + G +D+++NNAG F+ +EE + NF+GV +T+ L MR
Sbjct: 68 DAKRRFGNVDIVINNAGYGLVGEFESYNIEEMHRQM-----NVNFWGVAYITKEALNLMR 122
Query: 121 EQ-RHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV-KKFGIHVSTIDPHII 178
E + G+I+ ISS+ G P P ++Y +SK A+EG ++++ E+ + I ++ + P +
Sbjct: 123 ESGKGGRILQISSVAGYYPSPCLSMYNASKFAVEGLSQTIMRELDPNWNIAITIVQPGGM 182
Query: 179 KTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDE--PEVIAKEVLKVIKTENPKS 236
+T A+SN + Y++ + S R ++ +E P A+ + + K + P
Sbjct: 183 QTEWASSNMQWAKPHPAYENDR---SWRPFWENYHGCEETDPNKAAELLYSIAKLDRPPQ 239
Query: 237 RYTPGKAKL 245
+ G L
Sbjct: 240 KLVLGHDSL 248
>7290108 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 95.5 bits (236), Expect = 7e-20
Identities = 60/179 (33%), Positives = 99/179 (54%), Gaps = 6/179 (3%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK-GSIPGKEYSFKMIKLDITDEESV 59
+ +V+++TGAS+GIG +IA+ L G + R ++ + S K + +I +
Sbjct: 3 LSNKVVIVTGASSGIGAAIAQVLAREGATLALVGRNVANLEATKKSLKGTQAEIVVADVT 62
Query: 60 KSA---VNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVL 116
K A V + + K GRIDVLVNNAGI K ++ + + TN GV +T+AVL
Sbjct: 63 KDADAIVQQTLAKFGRIDVLVNNAGILGKGGLID-LDIEEFDAVLNTNLRGVILLTKAVL 121
Query: 117 PHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
PH+ + + G ++N+SS GI P Y SK AL+ +T+ + E+ G+ V++++P
Sbjct: 122 PHLLKTK-GAVVNVSSCAGIRPFAGALSYGVSKAALDQFTKIVALEMAPQGVRVNSVNP 179
>Hs7705907 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 95.1 bits (235), Expect = 9e-20
Identities = 66/224 (29%), Positives = 110/224 (48%), Gaps = 21/224 (9%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVF--------GTSRKGSIPGKEYSFKMIKLDITD 55
+V+++TG GIG I ++G V G + + +PG + I D+T
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVF----ILCDVTQ 65
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E+ VK+ V+E I + GR+D +VNNAG EE S + + E N G + +T+
Sbjct: 66 EDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLA 125
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
LP++R+ + G +INISS+ G + Y ++K A+ T++L + +G+ V+ I P
Sbjct: 126 LPYLRKSQ-GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISP 184
Query: 176 HIIKTGMANSNSPADEEM-AVYDSIKGKVSERMLKQSLENSDEP 218
N +P EE+ A+ + + E ML Q L +P
Sbjct: 185 -------GNIWTPLWEELAALMPDPRASIREGMLAQPLGRMGQP 221
>HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 94.7 bits (234), Expect = 1e-19
Identities = 77/283 (27%), Positives = 143/283 (50%), Gaps = 24/283 (8%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGT--SRKGS--IPGKEYS-FKMIKLDITD 55
++ + + ITG +G G +A L + G V + KG+ + G+ + + LD+T
Sbjct: 27 LRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTK 86
Query: 56 EESVKSA---VNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
ESV +A V E + G + LVNNAGI+ A E + TI + N GV +T
Sbjct: 87 TESVAAAAQWVKECVRDKG-LWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVT 145
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
++LP +R+ R G+++N+SS+ G + + +G YC SK+ +E +++SL E+ FG+ V+
Sbjct: 146 LSLLPLVRKAR-GRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRRELSYFGVKVAM 203
Query: 173 IDPHIIKTGMANSNSPADEEMAVYD----SIKGKVSERMLKQSLENSDEPEVIAKEVLKV 228
I+P KT + + + ++D +K E+ + +++++ E + L +
Sbjct: 204 IEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQDLSL 263
Query: 229 IK--------TENPKSRYTPG-KAKLYAYFSYYTPSWIFRRIL 262
+ +P++RY+ G AKL Y P+++ I+
Sbjct: 264 VTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306
>YMR226c [Q] KOG1205 Predicted dehydrogenase
Length = 267
Score = 94.0 bits (232), Expect = 2e-19
Identities = 65/207 (31%), Positives = 107/207 (51%), Gaps = 13/207 (6%)
Query: 1 MKKQVILITGASTGIGLSIA-ETLRSAGYEVFGTSRKGSIPGKEYSFKMI---------- 49
+ K+ +LITGAS GIG + A E L ++ ++ + E K I
Sbjct: 11 LAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVH 70
Query: 50 --KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFG 107
+LDIT E +K + + ++ ID+LVNNAG A V + +T+ + +F+TN
Sbjct: 71 VAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTA 130
Query: 108 VHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFG 167
+ +T+AVLP + + G I+N+ S+ G P G++YC+SK A+ +T+SL E+
Sbjct: 131 LINITQAVLPIFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELINTK 190
Query: 168 IHVSTIDPHIIKTGMANSNSPADEEMA 194
I V I P +++T + +EE A
Sbjct: 191 IRVILIAPGLVETEFSLVRYRGNEEQA 217
>Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 92.8 bits (229), Expect = 4e-19
Identities = 75/282 (26%), Positives = 137/282 (47%), Gaps = 22/282 (7%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGT--SRKGS--IPGKEYS-FKMIKLDITD 55
++ + + ITG +G G +A L + G V + KG+ + G+ + + LD+T
Sbjct: 27 LQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTK 86
Query: 56 EESVKSAVNEVIEKAGRIDV--LVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
ES+ +A V E G + LVNNAGI E +T+ + + + N GV ++T
Sbjct: 87 MESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTL 146
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
++LP +R R G+I+N+SS+ G + G YC SK+ +E +++ L E++ FG+ +S +
Sbjct: 147 SMLPLVRRAR-GRIVNVSSILGRVAFFVGG-YCVSKYGVEAFSDILRREIQHFGVKISIV 204
Query: 174 DPHIIKTGMANSNSPADEEMAVYDSIKGKVSE-----------RMLKQSLEN-SDEPEVI 221
+P +TGM N + + + E ++K+ L N S ++
Sbjct: 205 EPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLV 264
Query: 222 AKEVLKVIKTENPKSRYTPG-KAKLYAYFSYYTPSWIFRRIL 262
+ + + +P++RY+ G AK + Y P+ + IL
Sbjct: 265 TDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYIL 306
>Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 323
Score = 92.4 bits (228), Expect = 6e-19
Identities = 73/264 (27%), Positives = 130/264 (48%), Gaps = 24/264 (9%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGT--SRKGSIPGKEYSFKMIK---LDITDEESVK 60
I ITG +G G A T G+ V + GS K + + ++ LD+TD E+VK
Sbjct: 32 IFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVK 91
Query: 61 SAVNEVIEKAGRIDV--LVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPH 118
V + G + L+NNAG+ A + + + + E N FG+ +T +LP
Sbjct: 92 RTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPR 151
Query: 119 MREQRHGK---IINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
+E + G+ + G +P G Y SK+A+EG+ +SL ++K FG+HVS I+P
Sbjct: 152 PQEDQPGQGGTTLPSPCTAGKLP-SVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEP 210
Query: 176 HIIKTGMANSNSPADEEMAVYD----SIKGKVSERMLKQSLEN-SDEPEVIAKEVLKVIK 230
+ KT +A+ ++++A+++ IK + E +++SL+ + ++ V++
Sbjct: 211 GLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVE 270
Query: 231 TEN-------PKSRYTPGK-AKLY 246
+ PK+ Y GK AK++
Sbjct: 271 CMDHALTSLFPKTHYAAGKDAKIF 294
>7296047 [Q] KOG1205 Predicted dehydrogenase
Length = 321
Score = 92.4 bits (228), Expect = 6e-19
Identities = 61/193 (31%), Positives = 105/193 (53%), Gaps = 21/193 (10%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK----------------GSIPGKEY 44
M+ QV+ ITGAS+GIG ++A +L G ++ ++R+ G + K+
Sbjct: 44 MRGQVVWITGASSGIGRALALSLARHGVKLVLSARRLEQLEQVQEECLAAARGLLATKDV 103
Query: 45 SFKMIKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETN 104
+I++D+ D + K+ +N V+ R+DVLVNNAG + + A+ E ++ + +FE +
Sbjct: 104 L--VIQMDMLDLDEHKTHLNTVLNHFHRLDVLVNNAGRSQR-ASWTEVEIEVDRELFELD 160
Query: 105 FFGVHRMTRAVLPHMREQRHGK--IINISSMGGIMPIPYGALYCSSKHALEGYTESLDYE 162
F V ++R V+ + EQ G+ I SS+ G P+P+ YC++KHAL Y SL E
Sbjct: 161 VFAVVHLSRLVVRYFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVE 220
Query: 163 VKKFGIHVSTIDP 175
++K + + P
Sbjct: 221 MRKLDVSLFAPGP 233
>YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 297
Score = 91.7 bits (226), Expect = 1e-18
Identities = 74/276 (26%), Positives = 134/276 (47%), Gaps = 17/276 (6%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVFGTSRKG------SIPGKEYSFKMIKLDITDE 56
K++ ++TGAS GIG + + L GY V+ +R+ +I S K KLDI+
Sbjct: 9 KKIAVVTGASGGIGYEVTKELARNGYLVYACARRLEPMAQLAIQFGNDSIKPYKLDISKP 68
Query: 57 ESVK--SAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLA-KTIFETNFFGVHRMTR 113
E + S G++D+L NNAG + + A++ +TD A + F+ N FG M R
Sbjct: 69 EEIVTFSGFLRANLPDGKLDLLYNNAGQSCTFPALD--ATDAAVEQCFKVNVFGHINMCR 126
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
+ + + + G I+ S+ G++ P+G++Y +SK A+ Y L E+K F + V
Sbjct: 127 ELSEFLIKAK-GTIVFTGSLAGVVSFPFGSIYSASKAAIHQYARGLHLEMKPFNVRVINA 185
Query: 174 DPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLK-QSLENSDEP-EVIAKEVLK-VIK 230
+ T +A+ E ++Y+ +G+ + K + +N P + AK+++K ++
Sbjct: 186 ITGGVATDIADKRPL--PETSIYNFPEGREAFNSRKTMAKDNKPMPADAYAKQLVKDILS 243
Query: 231 TENPKSRYTPGKAKLYAYFSYYTPSWIFRRILDTVF 266
T +P Y A + + + P W+ + L F
Sbjct: 244 TSDPVDVYRGTFANIMRFVMIFVPYWLLEKGLSKKF 279
>Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 91.3 bits (225), Expect = 1e-18
Identities = 76/283 (26%), Positives = 140/283 (48%), Gaps = 24/283 (8%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGT--SRKGS--IPGKEYS-FKMIKLDITD 55
++ + + ITG +G G +A L + G V + KG+ + G+ + + LD+T
Sbjct: 27 LRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTK 86
Query: 56 EESVKSA---VNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
ESV +A V E + G + LVNNAGI+ A E + TI + N GV +T
Sbjct: 87 TESVAAAAQWVKECVRDKG-LWGLVNNAGISLPTAPNELLTKQDLLTILDVNLLGVIDVT 145
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
+LP +R R G+++N+ S+ G + + +G YC SK+ +E +++SL E+ FG+ V+
Sbjct: 146 LNLLPLVRRAR-GRVVNVFSVMGRVSL-FGGGYCISKYGVEAFSDSLRRELSYFGVKVAM 203
Query: 173 IDPHIIKTGMANSNSPADEEMAVYD----SIKGKVSERMLKQSLENSDEPEVIAKEVLKV 228
I+P KT + + + ++D +K E+ + +++++ E + L +
Sbjct: 204 IEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQDLSL 263
Query: 229 IK--------TENPKSRYTPG-KAKLYAYFSYYTPSWIFRRIL 262
+ +P++RY+ G AKL Y P+++ I+
Sbjct: 264 VTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306
>CE27259 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 501
Score = 91.3 bits (225), Expect = 1e-18
Identities = 59/189 (31%), Positives = 98/189 (51%), Gaps = 13/189 (6%)
Query: 5 VILITGASTGIGLSIAETLRSAGYEVFGTSRK----GSIPGKEYSFKMIKLDI------- 53
V ++TGAS+GIG + A L Y++ T R + G+ S K D+
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVEL 62
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
EE+ K+ V+ ++K GRID L+N+AGI + V + ++ + N + R+TR
Sbjct: 63 ASEEAPKTIVDATVQKFGRIDTLINSAGI-LRAGPVLDSGIEVYDELMNVNVRSLIRLTR 121
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
A LPH+ + G ++N+SS+ G P P YC SK A++ +T+ L E+ G+ V+ +
Sbjct: 122 AALPHIITTK-GTVVNVSSINGPCPFPNVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAV 180
Query: 174 DPHIIKTGM 182
P + T +
Sbjct: 181 CPGVTVTNL 189
Score = 58.2 bits (139), Expect = 1e-08
Identities = 35/123 (28%), Positives = 65/123 (52%), Gaps = 5/123 (4%)
Query: 77 VNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPHMREQRHGKIINISSMGGI 136
+N+AGI + V + ++ + N + R+TRA LPH+ + G ++N+SS+ G
Sbjct: 381 INSAGI-LRAGPVLDSGIEVYDELMNVNVRSLIRLTRAALPHIITTK-GTVVNVSSINGP 438
Query: 137 MPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHIIKTGMANSNSPADEEMAVY 196
P YC SK A++ +T+ L E+ G+ V+ + P +I T N + + ++ A Y
Sbjct: 439 CPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVCPGVIVT---NIHRASGQDEATY 495
Query: 197 DSI 199
++
Sbjct: 496 AAV 498
>SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 296
Score = 90.5 bits (223), Expect = 2e-18
Identities = 58/175 (33%), Positives = 98/175 (55%), Gaps = 6/175 (3%)
Query: 3 KQVILITGASTG-IGLSIAETLRSAGYEVFGTSRKGSIPGK--EYSFKMIKLDITDEESV 59
++ +LITG S G IG ++A G++V T+R+ + + +KLD+TDE+SV
Sbjct: 4 EKFVLITGCSEGGIGNALALKFHQEGFQVLATARQVERMDNLTKAGLQTLKLDVTDEDSV 63
Query: 60 KSAVNEVIEKA-GRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPH 118
+ EV + G + L+NNAG A++ D++K + + NF+GV RM +A H
Sbjct: 64 REVEQEVRKFTNGSLHYLINNAGAPCSAPAIDLDIEDVSK-VMDVNFYGVIRMNKA-FQH 121
Query: 119 MREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
+ G I+N++S+ +P + A Y +SK AL Y+ +L E+ FG+ V++I
Sbjct: 122 QLIRAKGTIVNVNSLVSYVPFAFNAAYNASKAALLAYSNTLRIELAPFGVQVTSI 176
>Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 343
Score = 90.5 bits (223), Expect = 2e-18
Identities = 61/186 (32%), Positives = 100/186 (52%), Gaps = 17/186 (9%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFG---TSRKGSIPGKEYS------FKMIKLDIT 54
+ +L+TG +G G S+A+ L S G+ VF KG KE + ++L++
Sbjct: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
Query: 55 DEESVKSAVNEVIEKAGRIDV-----LVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
E V+ V E++ + + LVNNAGI+ + VE S + K + E N +G
Sbjct: 116 SSEEVEKVV-EIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLWGTV 173
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
RMT++ LP +R + G+++NISSM G M P + YC +K +E +++ L YE+ G+
Sbjct: 174 RMTKSFLPLIRRAK-GRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVK 232
Query: 170 VSTIDP 175
VS ++P
Sbjct: 233 VSVVEP 238
>CE27260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 206
Score = 90.5 bits (223), Expect = 2e-18
Identities = 62/206 (30%), Positives = 106/206 (51%), Gaps = 16/206 (7%)
Query: 5 VILITGASTGIGLSIAETLRSAGYEVFGTSRK----GSIPGKEYSFKMIKLDI------- 53
V ++TGAS+GIG + A L Y++ T R + G+ S K D+
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVEL 62
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
EE+ K+ V+ ++K GRID L+N+AGI + V + ++ + N + R+TR
Sbjct: 63 ASEEAPKTIVDATVQKFGRIDTLINSAGI-LRAGPVLDSGIEVYDELMNVNVRSLIRLTR 121
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
A LPH+ + G ++N+SS+ G P YC SK A++ +T+ L E+ G+ V+ +
Sbjct: 122 AALPHIITTK-GTVVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAV 180
Query: 174 DPHIIKTGMANSNSPADEEMAVYDSI 199
P +I T N + + ++ A Y ++
Sbjct: 181 CPGVIVT---NIHRASGQDEATYAAV 203
>At1g10310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 242
Score = 89.7 bits (221), Expect = 4e-18
Identities = 58/189 (30%), Positives = 97/189 (50%), Gaps = 8/189 (4%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKG-------SIPGKEYSFKMIKLDITDE 56
+ +LITG S G+G ++A L G+ V G +R S + ++ D+
Sbjct: 18 RTVLITGVSKGLGRALALELAKRGHTVIGCARSQEKLTALQSELSSSTNHLLLTADVKSN 77
Query: 57 ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVL 116
SV+ + ++EK G D++VNNAG K + + E S + + +TN GV + R +
Sbjct: 78 SSVEEMAHTIVEKKGVPDIIVNNAGTINKNSKIWEVSAEDFDNVMDTNVKGVANVLRHFI 137
Query: 117 PHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPH 176
P M ++ G I+N+SS G A YC+SK A+EG + ++ EV + G+ V ++P
Sbjct: 138 PLMLPRKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKEVVE-GMAVVALNPG 196
Query: 177 IIKTGMANS 185
+I T + S
Sbjct: 197 VINTELLTS 205
>CE21095 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 88.6 bits (218), Expect = 8e-18
Identities = 62/205 (30%), Positives = 100/205 (48%), Gaps = 20/205 (9%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIK 50
+ ++ITG+S GIG + A G V T R K + K+ + +
Sbjct: 7 KTVIITGSSNGIGRTTAILFAQEGANVTITGRSSERLEETRQIILKSGVSEKQVN--SVV 64
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWA---AVEECSTDLAKTIFETNFFG 107
D+T E+ +N +++ G+IDVLVNNAG A A + D+ + N
Sbjct: 65 ADVTTEDGQDQIINSTLKQFGKIDVLVNNAGAAIPDAFGTTGTDQGIDIYHKTLKLNLQA 124
Query: 108 VHRMTRAVLPHMREQRHGKIINISSM-GGIMPIPYGALYCSSKHALEGYTESLDYEVKKF 166
V MT+ V PH+ + G+I+N+SS+ G P Y +K AL+ YT S ++ KF
Sbjct: 125 VIEMTKKVKPHLVASK-GEIVNVSSIVAGPQAQPDFLYYAIAKAALDQYTRSTAIDLAKF 183
Query: 167 GIHVSTIDPHIIKTGMANSNSPADE 191
GI V+++ P +++TG N+ D+
Sbjct: 184 GIRVNSVSPGMVETGFTNAMGMPDQ 208
>Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 266
Score = 88.2 bits (217), Expect = 1e-17
Identities = 68/244 (27%), Positives = 120/244 (48%), Gaps = 28/244 (11%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVF--------GTSRKGSIPGKEYSFK--MIKLDI 53
+V L+TGA+ GIG + AE L G +V G K ++ + K I+ D+
Sbjct: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKTLFIQCDV 65
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
D++ ++ +V++ GR+D+LVNNAG+ + KT+ + N V T
Sbjct: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTL-QINLVSVISGTY 116
Query: 114 AVLPHMREQRHGK---IINISSMGGIMPIPYGALYCSSKHALEGYTES--LDYEVKKFGI 168
L +M +Q G+ IIN+SS+ G+MP+ +YC+SKH + G+T S L + G+
Sbjct: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGV 176
Query: 169 HVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKV 228
++ I P + T + S +E M Y K + + + + +P +IA ++ +
Sbjct: 177 RLNAICPGFVNTAILES-IEKEENMGQYIEYKDHIKDMIKYYGIL---DPPLIANGLITL 232
Query: 229 IKTE 232
I+ +
Sbjct: 233 IEDD 236
>Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 313
Score = 88.2 bits (217), Expect = 1e-17
Identities = 68/260 (26%), Positives = 122/260 (46%), Gaps = 21/260 (8%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGT--SRKGSIP---GKEYSFKMIKLDITD 55
+ ++ + ITG +G G +A+ L G +V + +GS Y + LD+T
Sbjct: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTK 82
Query: 56 EESVKSAVNEVIEKAGR--IDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
ES+K+A V +K G + LVNNAG+ E + D + N G+ +T
Sbjct: 83 SESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEVTL 142
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
+LP ++ R G+++N+SS GG + + G YC SK +E +++S+ E+ FG+ V I
Sbjct: 143 HMLPMVKRAR-GRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRRELYYFGVKVCII 200
Query: 174 DPHIIKTGMANSNSPADEEMAVYDSIKGKVSE-------RMLKQSLEN---SDEPEV--I 221
+P +T + + +++ + + + R+ L+N EP V +
Sbjct: 201 EPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQVAEPRVRDV 260
Query: 222 AKEVLKVIKTENPKSRYTPG 241
+ I + +P+ RY PG
Sbjct: 261 INSMEHAIVSRSPRIRYNPG 280
>Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 87.8 bits (216), Expect = 1e-17
Identities = 60/200 (30%), Positives = 97/200 (48%), Gaps = 22/200 (11%)
Query: 4 QVILITGASTGIG-------------LSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIK 50
+++LITGA GIG L + + + E RK + Y
Sbjct: 37 EIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYV----- 91
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHR 110
+D ++ E + ++N+V ++ G + ++VNNAG + + ++ KT FE N G
Sbjct: 92 VDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKT-FEVNILGHFW 150
Query: 111 MTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVK---KFG 167
+T+A+LP M E+ HG I+ ++S+ G IPY YCSSK A G+ L E++ K G
Sbjct: 151 ITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTG 210
Query: 168 IHVSTIDPHIIKTGMANSNS 187
I S + P + TG + S
Sbjct: 211 IKTSCLCPVFVNTGFTKNPS 230
>CE07544 [Q] KOG1205 Predicted dehydrogenase
Length = 262
Score = 87.8 bits (216), Expect = 1e-17
Identities = 66/221 (29%), Positives = 113/221 (50%), Gaps = 24/221 (10%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSR------------KGSIPGKEYSFKM 48
+K +V++ITGAS+G+G S+A L G +V +R K + P +
Sbjct: 45 VKNKVVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICEELKETFPLNQNEPIY 104
Query: 49 IKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
DITD E A + R+D+L+NNAG++ + + ++ + ++ + ETN+FG
Sbjct: 105 YYFDITDSEQAPWA------EIPRVDILINNAGMSNR-GSCQDTTMEIHRQAMETNYFGH 157
Query: 109 HRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
+T+A+L + G I+ SS+ G + IPY Y +SKHAL+GY + L E K +
Sbjct: 158 VHVTQALLSKLSPD--GCIVVTSSIQGKVAIPYRGSYGASKHALQGYFDCLRAEHK--NL 213
Query: 169 HVSTIDPHIIKTGM-ANSNSPADEEMAVYDSIKGKVSERML 208
H+ + I TG + + P+ + + V D + KV + +
Sbjct: 214 HILVVSAGYINTGFGSRALDPSGKVVGVEDENQKKVVKHFI 254
>CE03132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 87.8 bits (216), Expect = 1e-17
Identities = 71/218 (32%), Positives = 112/218 (50%), Gaps = 26/218 (11%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVFGTSR---------KGSIPG--KEYSFKMIKL 51
K+V +ITG+S+GIG A G +V T R K + KE +F ++
Sbjct: 7 KKVAIITGSSSGIGRETALLFAKEGAKVTVTGRSEEKLEETKKALLDAGIKESNFLIVPA 66
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGI----AFKWAAVEECSTDLAKTIFETNFFG 107
DIT +++ ++K GRI++LVNNAG A K +++ + + + + N
Sbjct: 67 DITFSTGQDELISQTLKKFGRINILVNNAGASIPDAKKRTGIDQ-GIETYEQVMKLNVQS 125
Query: 108 VHRMTRAVLPHMREQRHGKIINISSM----GGIMPIPYGALYCSSKHALEGYTESLDYEV 163
V MT+ V PH+ + R G+I+N+SS+ G PY Y +K AL+ YT S +
Sbjct: 126 VIEMTQKVRPHLAKSR-GEIVNVSSVVALKAGWTRTPY---YPLAKAALDQYTRSAAIAL 181
Query: 164 KKFGIHVSTIDPHIIKTG-MAN-SNSPADEEMAVYDSI 199
GI V+T++P I++TG AN S S +D+ YD +
Sbjct: 182 ISEGIRVNTVNPGIVQTGFQANASGSSSDDAQKFYDDM 219
>7296705 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 87.4 bits (215), Expect = 2e-17
Identities = 56/188 (29%), Positives = 95/188 (49%), Gaps = 11/188 (5%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAG---------YEVFGTSRKGSIPGKEYSFKMIKLD 52
K +VI++TGAS+GIG + L G + + + + + D
Sbjct: 5 KDKVIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVAAD 64
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
I E V+ V+ + K GRIDVLVNNAGI + ++E S + + TN ++++T
Sbjct: 65 INSESDVQGIVSATLAKHGRIDVLVNNAGI-LELGSIENTSLEQFDRVMNTNVRSLYQLT 123
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
V P + + + G I+N+SS+ GI P Y SK A++ +T + E+ G+ V++
Sbjct: 124 HLVTPELIKTK-GNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVNS 182
Query: 173 IDPHIIKT 180
++P +I T
Sbjct: 183 VNPGVIIT 190
>At3g55310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 298
Score = 85.5 bits (210), Expect = 7e-17
Identities = 63/194 (32%), Positives = 101/194 (51%), Gaps = 14/194 (7%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK----GSIPGKEYSFKM-------I 49
+K +V+L+TGAS+GIG I L AG +V +R+ S+ + SF +
Sbjct: 36 LKDKVVLVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQAAAL 95
Query: 50 KLDIT-DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
+LD++ D +++ AV E + G+ID L+NNAGI + S D +F TN G
Sbjct: 96 ELDVSSDAATIQKAVREAWDIFGKIDALINNAGIRGNVKLSLDLSEDEWDNVFNTNLKGP 155
Query: 109 HRMTRAVLPHMRE-QRHGKIINISSMGGIMPI-PYGALYCSSKHALEGYTESLDYEVKKF 166
+ + V MR+ +R G +INISS+ G+ I P G Y SK ++ + + E+
Sbjct: 156 WLVAKYVCVLMRDAKRGGSVINISSVAGVRSIVPGGLAYSCSKGGVDTMSRMMAIELGVH 215
Query: 167 GIHVSTIDPHIIKT 180
I V++I P + K+
Sbjct: 216 KIRVNSIAPGLFKS 229
>At1g63380 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 287
Score = 85.5 bits (210), Expect = 7e-17
Identities = 62/195 (31%), Positives = 105/195 (53%), Gaps = 15/195 (7%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK----GSIPGKEYSFKMI------- 49
+K +V+L+TGAS+GIG I L AG ++ +R+ S+ + SF I
Sbjct: 22 LKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAVAL 81
Query: 50 KLDITDE-ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
+LD++ E ++++ AV E E G+IDVL+NNAGI + + S + +F TN G
Sbjct: 82 ELDVSSEADTIRKAVKEAWETFGKIDVLINNAGIRGNVKSSLDLSEEEWDKVFRTNLTGS 141
Query: 109 HRMTRAVLPHMRE-QRHGKIINISSMGGIMP--IPYGALYCSSKHALEGYTESLDYEVKK 165
+++ V MR+ +R G +IN+SS+ G+ + G Y SK ++ T + E+
Sbjct: 142 WLISKYVCLLMRDAERGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELAV 201
Query: 166 FGIHVSTIDPHIIKT 180
+ I V++I P I ++
Sbjct: 202 YKIRVNSIAPGIFRS 216
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 84.3 bits (207), Expect = 2e-16
Identities = 63/205 (30%), Positives = 99/205 (47%), Gaps = 21/205 (10%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIK 50
+V L+TG+S GIG + A L G +V T R K +P E I
Sbjct: 7 KVALVTGSSNGIGRATAVLLAQEGAKVTITGRNADRLEETRQEILKSGVP--EDHVLSIA 64
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAF---KWAAVEECSTDLAKTIFETNFFG 107
D+ E+ VN I+K GR+D+LVNNAG AF + + + I + N
Sbjct: 65 TDLATEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDRIMQINMRS 124
Query: 108 VHRMTRAVLPHMREQRHGKIINISSMG-GIMPIPYGALYCSSKHALEGYTESLDYEVKKF 166
V +T+ H+ + + G+++N+SS+G G P Y SK AL+ YT S ++ ++
Sbjct: 125 VVTLTQKAKEHLVKAK-GEVVNVSSIGAGPQAQPTFMYYAMSKAALDQYTRSAAIDLIQY 183
Query: 167 GIHVSTIDPHIIKTGMANS-NSPAD 190
G+ V+++ P + TG + PAD
Sbjct: 184 GVRVNSVSPGAVVTGFGEAMGMPAD 208
>Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 405
Score = 83.6 bits (205), Expect = 3e-16
Identities = 79/290 (27%), Positives = 121/290 (41%), Gaps = 32/290 (11%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGK-------EYSFKMIKLDITDE 56
+ +LITG +G G A+ L S G+ V T + + PG +++++D+T
Sbjct: 83 RAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKP 142
Query: 57 ESVKSAVNEVIEKAGRIDV----LVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+ + KA LVNNAG A E ++ E NFFG +T
Sbjct: 143 GDISRLLE--FTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELT 200
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
+ +LP +R R G+I+ + S G MP P Y +SK A+ ++ E+ +G+ VS
Sbjct: 201 KGLLPLLRSSR-GRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259
Query: 173 IDPHIIKTGMAN-------------SNSPADEEMAVY--DSIKGKVSERMLKQSLENSDE 217
I P KT +N P E + Y D I+ + + L SD
Sbjct: 260 IQPGCFKTESVRNVGQWEKRKQLLLANLP-QELLQAYGKDYIEHLHGQFLHSLRLAMSDL 318
Query: 218 PEVIAKEVLKVIKTENPKSRYTPGKAKLYAYF-SYYTPSWIFRRILDTVF 266
V+ + + P+ RY PG+ YF YY P + RR L F
Sbjct: 319 TPVV-DAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFF 367
>CE03954 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 274
Score = 83.6 bits (205), Expect = 3e-16
Identities = 62/213 (29%), Positives = 103/213 (48%), Gaps = 22/213 (10%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIK 50
+V +ITG+S GIG + A L + G +V T R K I + +
Sbjct: 7 KVAIITGSSNGIGRATAVLLATDGAKVTITGRDAARLEETRQAILKAGISATNVN--SVV 64
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVE---ECSTDLAKTIFETNFFG 107
D+T E ++ ++K G+I++L+NNAG + + +CS + +F+ N
Sbjct: 65 ADVTTAEGQDLLISSTLDKFGKINILINNAGANIPDSQGQTRTKCSIENLTKMFQLNLQS 124
Query: 108 VHRMTRAVLPHMREQRHGKIINISSMG-GIMPIPYGALYCSSKHALEGYTESLDYEVKKF 166
V M + V PH+ + R G+I+NISS+G G P Y S+K AL+ Y+ ++
Sbjct: 125 VVEMVQKVRPHLAKTR-GEIVNISSIGAGPAAQPASPYYSSAKAALDQYSRCAAIDLISE 183
Query: 167 GIHVSTIDPHIIKTGMANS--NSPADEEMAVYD 197
GI ++ + P + TG + + ADE + YD
Sbjct: 184 GIRINVVQPGFVSTGFSTAARGLSADESVKFYD 216
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 83.2 bits (204), Expect = 4e-16
Identities = 68/211 (32%), Positives = 104/211 (49%), Gaps = 18/211 (8%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIPGK---EYSFKMIKLD 52
+V +ITG+S GIG + A L S G +V T R K + G E + ++ D
Sbjct: 7 KVAIITGSSNGIGQATARLLASEGAKVTVTGRNAERLEETKNILLGAGVPEGNVLVVVGD 66
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVE---ECSTDLAKTIFETNFFGVH 109
IT E ++ + ++K G+ID+LVNNAG A + S D FE N V
Sbjct: 67 ITQESVQENLIKSTLDKFGKIDILVNNAGAGIPDAQGKSGVNQSIDTYHKTFELNVQSVI 126
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCS-SKHALEGYTESLDYEVKKFGI 168
MT+ PH+ + + G+I+NISS+G + Y S +K AL+ YT + ++ GI
Sbjct: 127 EMTQKARPHLAKTQ-GEIVNISSIGAGPAAQVASPYYSIAKAALDQYTRTAAIDLVPEGI 185
Query: 169 HVSTIDPHIIKTGMANSNSPADEE--MAVYD 197
V+++ P + TG + + EE A YD
Sbjct: 186 RVNSVSPGAVSTGFSAVSRGLTEEKSKAFYD 216
>At1g62610 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 307
Score = 83.2 bits (204), Expect = 4e-16
Identities = 62/195 (31%), Positives = 104/195 (52%), Gaps = 15/195 (7%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK----GSIPGKEYSFKMI------- 49
+K +V+L+TGAS+GIG I L AG ++ +R+ S+ + SF I
Sbjct: 44 LKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAAAL 103
Query: 50 KLDIT-DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
+LD++ D ++++ AV E E G IDVL+NNAGI + + S + +F TN G
Sbjct: 104 ELDVSSDADTIRKAVKEAWEIFGTIDVLINNAGIRGNVKSSLDLSKEEWDKVFRTNLTGS 163
Query: 109 HRMTRAVLPHMRE-QRHGKIINISSMGGIMP--IPYGALYCSSKHALEGYTESLDYEVKK 165
+++ V MR+ +R G +IN+SS+ G+ + G Y SK ++ T + E+
Sbjct: 164 WLISKYVCLLMRDAKRGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELAV 223
Query: 166 FGIHVSTIDPHIIKT 180
+ I V++I P I ++
Sbjct: 224 YKIRVNSIAPGIFRS 238
>YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 900
Score = 82.4 bits (202), Expect = 6e-16
Identities = 60/190 (31%), Positives = 97/190 (50%), Gaps = 18/190 (9%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKLDITDE----- 56
K +V++ITGA G+G A S G +V G++ G ++ K L + DE
Sbjct: 8 KDRVVVITGAGGGLGKVYALAYASRGAKVVVNDLGGTLGGSGHNSKAADL-VVDEIKKAG 66
Query: 57 -------ESVKSAVNEVIEKA----GRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNF 105
+SV ++IE A GR+DVL+NNAGI + + + A + + +
Sbjct: 67 GIAVANYDSVNENGEKIIETAIKEFGRVDVLINNAGILRDVSFAKMTEREFASVV-DVHL 125
Query: 106 FGVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKK 165
G ++++RA P+MR Q+ G+IIN +S G+ A Y ++K L G E+L E K
Sbjct: 126 TGGYKLSRAAWPYMRSQKFGRIINTASPAGLFGNFGQANYSAAKMGLVGLAETLAKEGAK 185
Query: 166 FGIHVSTIDP 175
+ I+V++I P
Sbjct: 186 YNINVNSIAP 195
Score = 62.4 bits (150), Expect = 6e-10
Identities = 52/179 (29%), Positives = 85/179 (47%), Gaps = 7/179 (3%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIK--LDITDEESVKS 61
+V+++TGA G+G S A G +V K E K+ I D V +
Sbjct: 323 KVVVVTGAGGGLGKSHAIWFARYGAKVVVNDIKDPFSVVEEINKLYGEGTAIPDSHDVVT 382
Query: 62 A----VNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLP 117
+ I K R+D+LVNNAGI + + + + + + + F +++AV P
Sbjct: 383 EAPLIIQTAISKFQRVDILVNNAGI-LRDKSFLKMKDEEWFAVLKVHLFSTFSLSKAVWP 441
Query: 118 HMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPH 176
+Q+ G IIN +S GI A Y ++K A+ G+++++ E K GI V+ I PH
Sbjct: 442 IFTKQKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAKRGIIVNVIAPH 500
>CE03951 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 82.4 bits (202), Expect = 6e-16
Identities = 71/242 (29%), Positives = 116/242 (47%), Gaps = 28/242 (11%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR-----KGSIPG------KEYSFKMIKLD 52
+V +ITG+S GIG + A G +V T R +GS + +F ++ D
Sbjct: 8 KVAIITGSSFGIGRATALLFAKEGAKVTVTGRSEERLQGSKQALLDAGISDSNFLIVPAD 67
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAF---KWAAVEECSTDLAKTIFETNFFGVH 109
IT + +++ +EK G+I++LVNNAG + + A + D + + + N V
Sbjct: 68 ITTSSGQDALISKTLEKFGQINILVNNAGASIADSQNRAGLDQGIDTYEKVLKLNVQSVI 127
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGI----MPIPYGALYCSSKHALEGYTESLDYEVKK 165
MT+ + PH+ + R G+I+N+SS+ + + PY Y +K AL+ YT S ++
Sbjct: 128 EMTQKIRPHLAKTR-GEIVNVSSVAALKFAHVRNPY---YPLAKAALDQYTRSAAIDLIS 183
Query: 166 FGIHVSTIDPHIIKTGMANS--NSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAK 223
GI V+T++P ++ TG S +E YD KV S PE IAK
Sbjct: 184 QGIRVNTVNPGVVATGFHESCTGLSTEESQKFYD----KVGANKSAIPCGFSGRPEHIAK 239
Query: 224 EV 225
+
Sbjct: 240 AI 241
>CE06649 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 81.6 bits (200), Expect = 1e-15
Identities = 58/196 (29%), Positives = 99/196 (49%), Gaps = 23/196 (11%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGS-----------IPGKEYSFKMIKLD 52
+V+LI+G+S GIG + A + G ++ R + K + D
Sbjct: 9 KVVLISGSSKGIGQATAVKFAAEGAKIVLNGRSADDVEKTRKLCMEVGAKPWDLLPTVGD 68
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAG---IAFKWAAVEECSTDLAKTIFETNFFGVH 109
IT+E+ VK VN VI G++D+L+NNAG + E D+ + +NF V
Sbjct: 69 ITNEDFVKMMVNTVIHNFGKLDILINNAGTLEVDMTGKEGWEMGVDVMDRSWNSNFKSVL 128
Query: 110 RMTRAVLPHMREQRHGKIINIS---SMG--GIMPIPYGALYCSSKHALEGYTESLDYEVK 164
+T+A +PH+ + + G I+N+S S G G+M +PY Y K AL+ + S+ +E
Sbjct: 129 MLTQAAMPHLIKTK-GDIVNVSTFLSSGPIGVMSMPY---YAVPKAALDQMSRSMAHEYM 184
Query: 165 KFGIHVSTIDPHIIKT 180
G+ ++T++P ++ T
Sbjct: 185 LKGVRLNTVNPGLVST 200
>At3g47360 [Q] KOG1205 Predicted dehydrogenase
Length = 309
Score = 81.6 bits (200), Expect = 1e-15
Identities = 57/190 (30%), Positives = 101/190 (53%), Gaps = 13/190 (6%)
Query: 3 KQVILITGASTGIGLSIA-ETLRSAGYEVFGTSRKGSIPGKEYSFK--------MIKLDI 53
++V+LITGAS+GIG +A E + Y R+ + + + +I D+
Sbjct: 47 RKVVLITGASSGIGEHVAYEYAKKGAYLALVARRRDRLEIVAETSRQLGSGNVIIIPGDV 106
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEE-CSTDLAKTIFETNFFGVHRMT 112
++ E K ++E I G++D L+NNAG+ F+ E+ A I + NF+G +T
Sbjct: 107 SNVEDCKKFIDETIRHFGKLDHLINNAGV-FQTVLFEDFTQIQDANPIMDINFWGTTYIT 165
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
+PH+R+ + GKI+ I+S +P+P ++Y +SK AL + E+L E+ I ++
Sbjct: 166 YFAIPHLRKSK-GKIVAITSGSANIPLPLASIYAASKAALLRFFETLRIELSP-DIKITI 223
Query: 173 IDPHIIKTGM 182
+ P ++ T M
Sbjct: 224 VLPGVVSTDM 233
>CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 427
Score = 80.9 bits (198), Expect = 2e-15
Identities = 54/195 (27%), Positives = 95/195 (48%), Gaps = 12/195 (6%)
Query: 4 QVILITGASTGIGLSIAETL--RSAGYEVFGTSRKG------SIPGKEYSFKMIKLDITD 55
Q ++ITG +G+G ++A R A + +++G +I + K DI+D
Sbjct: 42 QTVIITGGGSGLGRAMALDFAKRKAKVAIIDVNKEGGLETVKTIAAEGNMAKFWYCDISD 101
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
+++K E+ + G +++++ NA I + + E S +L + + N FG RA
Sbjct: 102 VDNMKKTAKEIEDTFGDVNIVICNAAI-LSFTSFMEISDELLRKCLDVNIFGTINTIRAF 160
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKK---FGIHVST 172
LP M + G I+ + S+ G G YC+SK A+ G ESL E++ GI +T
Sbjct: 161 LPKMETKNDGHIVCVCSIAGWSGETMGLSYCTSKFAVRGAMESLQMELRDRGLEGIKTTT 220
Query: 173 IDPHIIKTGMANSNS 187
+ P+ +T M N+
Sbjct: 221 LYPYFARTPMILENN 235
>At1g52340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 285
Score = 80.5 bits (197), Expect = 2e-15
Identities = 56/200 (28%), Positives = 97/200 (48%), Gaps = 13/200 (6%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPG-----------KEYSFKMIKLD 52
+V LITG +TGIG SI G +V + + G KE +F I D
Sbjct: 21 KVALITGGATGIGESIVRLFHKHGAKVCIVDLQDDLGGEVCKSLLRGESKETAF-FIHGD 79
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGI-AFKWAAVEECSTDLAKTIFETNFFGVHRM 111
+ E+ + +AV+ ++ G +D+L+NNAG+ + S + F+ N G
Sbjct: 80 VRVEDDISNAVDFAVKNFGTLDILINNAGLCGAPCPDIRNYSLSEFEMTFDVNVKGAFLS 139
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVS 171
+ M ++ G I+++ S+GG++ Y SKHA+ G T S+ E+ + GI V+
Sbjct: 140 MKHAARVMIPEKKGSIVSLCSVGGVVGGVGPHSYVGSKHAVLGLTRSVAAELGQHGIRVN 199
Query: 172 TIDPHIIKTGMANSNSPADE 191
+ P+ + T +A ++ P +E
Sbjct: 200 CVSPYAVATKLALAHLPEEE 219
>SPCC24B10.20 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 254
Score = 80.1 bits (196), Expect = 3e-15
Identities = 77/259 (29%), Positives = 120/259 (45%), Gaps = 32/259 (12%)
Query: 5 VILITGASTGIGLSIAETLRSA-GYEVFGTSRKGSIPGKEYSFK----------MIKLDI 53
V +I G + GIGLS+ + L + G VF ++R PG K +IKLD+
Sbjct: 8 VYVIVGGNRGIGLSLVKELSNKEGVTVFASARG---PGSASELKDWSKTHSNVHIIKLDV 64
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
T S K A +V + IDVL N+GI+ + V + S +L + ++TN G + +
Sbjct: 65 TSLRSAKDAAMQVEKVVKCIDVLWVNSGISKSFQPVLKTSDELWMSHYQTNVLGPIHVYQ 124
Query: 114 AVLPHMREQRHGKIINISS----MGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
A ++E + I+ SS MGG+ P Y A Y SK AL + + +E++K G
Sbjct: 125 AFYHLLKEGKLKNIVFTSSMAACMGGVRPNTYSA-YGQSKAALNYTMKEISFELEKDGFV 183
Query: 170 VSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVI 229
V +I P ++ T M + + K E M++ N+ PE A +LK++
Sbjct: 184 VVSIHPGVVNTDMF---------VNAMQKLASKYPE-MVESIKSNAISPEQSASSMLKIV 233
Query: 230 ---KTENPKSRYTPGKAKL 245
KTE+ Y KL
Sbjct: 234 DNLKTEDNGMFYNLDGTKL 252
>Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 312
Score = 80.1 bits (196), Expect = 3e-15
Identities = 69/266 (25%), Positives = 119/266 (43%), Gaps = 35/266 (13%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKLDI-TDEESVKSAVNE 65
++TG++ GIG S AE L G +V SR + S K + T +V A +
Sbjct: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113
Query: 66 VIEK-----AG-RIDVLVNNAGIAFKWAAVEECSTDL---AKTIFETNFFGVHRMTRAVL 116
+ +K AG I +LVNN G+++++ DL K + N V +MT+ VL
Sbjct: 114 IYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVL 173
Query: 117 PHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPH 176
P M E+ G I+NISS G++P+P +Y ++K ++ +++ L E + G+ V ++ P+
Sbjct: 174 PGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPY 233
Query: 177 IIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVIKTENPKS 236
+ T +A P ++ PE K +K + ++ +
Sbjct: 234 FVATKLAKIRKPTLDK-----------------------PSPETFVKSAIKTVGLQSRTN 270
Query: 237 RYTPGKAKLYAYFSYYTPSWIFRRIL 262
Y L PSWI+ +I+
Sbjct: 271 GYL--IHALMGSIISNLPSWIYLKIV 294
>Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 318
Score = 80.1 bits (196), Expect = 3e-15
Identities = 76/282 (26%), Positives = 131/282 (45%), Gaps = 25/282 (8%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGT----SRKGSIPGKEYS-FKMIKLDITDEESVK 60
+ ITG +G G +A L + V + S + G S F LDITD +S +
Sbjct: 31 VFITGCDSGFGRLLALQLDQKSFRVLASCLTPSGAEDLQGVASSGFNTTLLDITDPQSFQ 90
Query: 61 SAVNEV---IEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLP 117
A V +++AG LVNNAG+A + D + + N G +T A+LP
Sbjct: 91 QAAKWVEMHVKEAGLFG-LVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLALLP 149
Query: 118 HMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHI 177
+++ R G++INI+S+ G + G YC SK LE +++SL +V FGI S ++P
Sbjct: 150 LLQQAR-GRVINITSVLGRLAANGGG-YCVSKFGLEAFSDSLRRDVAHFGIRESIVEPGF 207
Query: 178 IKTGMANSNSPADEEMAVYDSIKGKVSE-----------RMLKQSLENSDEPEV--IAKE 224
+T + N S A + + +M ++ + +P++ +++
Sbjct: 208 FRTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNLICDPDLTKVSRC 267
Query: 225 VLKVIKTENPKSRYTPG-KAKLYAYFSYYTPSWIFRRILDTV 265
+ + +P++RY+PG AKL + Y P+ + +L V
Sbjct: 268 LEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVLTWV 309
>CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 388
Score = 80.1 bits (196), Expect = 3e-15
Identities = 59/215 (27%), Positives = 104/215 (47%), Gaps = 16/215 (7%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGT--SRKGSIP---------GKEYSFKMIKLDIT 54
++ITG +G G +A +L VF +++G G + ++LD+T
Sbjct: 35 VMITGCDSGFGRLLATSLLDKHVNVFAACFTQQGMASLHSEWKLKKGPKGQLYTLQLDVT 94
Query: 55 DEESVKSAVNEVI----EKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHR 110
+ SV SA + V E+ ++ LVNNAGI + CS D + N G R
Sbjct: 95 SQASVDSAKSFVTKILKEQNSKLWGLVNNAGIFSIHGPDDWCSVDEYASSLNVNTLGAVR 154
Query: 111 MTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV 170
M A +P +++ R G+I+ + S G + Y A Y ++K A+E Y + L E++ FG+ V
Sbjct: 155 MCHAFVPLIKKSR-GRIVTMGSTAGRLHGLYVAPYVTAKFAVEAYMDCLRLEMRPFGVSV 213
Query: 171 STIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSE 205
++P KT + N+++ +++S+ + E
Sbjct: 214 HILEPGCFKTELLNNDAQRMRIQKIWNSLSVETKE 248
>7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 242
Score = 80.1 bits (196), Expect = 3e-15
Identities = 57/184 (30%), Positives = 95/184 (50%), Gaps = 4/184 (2%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKLD-ITDEESVKSA 62
+VIL+TGA GIG ++ + L SAG V +RK + +F + + + + S A
Sbjct: 8 KVILVTGAGAGIGQALVKQLASAGATVIAVARKPEQLQQLVAFDPVHIQPLQLDLSGWQA 67
Query: 63 VNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPHMREQ 122
V E + K +D LVNNAG+A EE + T F+ N V +T+++LP +++
Sbjct: 68 VREGLAKVPLLDGLVNNAGVAII-KPFEELTEQDFDTHFDVNIKAVFNVTQSLLPRLKDG 126
Query: 123 RHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHIIKTGM 182
I+N+SS+ Y ++K AL+ T+SL E+ I V++++P ++ T M
Sbjct: 127 --ASIVNVSSIASSRSFGGHTAYSATKAALDSLTKSLALELGPRKIRVNSVNPTVVLTKM 184
Query: 183 ANSN 186
N
Sbjct: 185 GADN 188
>Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 300
Score = 79.7 bits (195), Expect = 4e-15
Identities = 56/199 (28%), Positives = 93/199 (46%), Gaps = 20/199 (10%)
Query: 4 QVILITGASTGIGLSIAET------------LRSAGYEVFGTSRKGSIPGKEYSFKMIKL 51
+++LITGA GIG A + G E KG + K ++F +
Sbjct: 37 EIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKG-LGAKVHTFVV--- 92
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
D ++ E + S+ +V + G + +LVNNAG+ + + KT FE N
Sbjct: 93 DCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKT-FEVNVLAHFWT 151
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKF---GI 168
T+A LP M + HG I+ ++S G + +P+ YCSSK A G+ ++L E+ G+
Sbjct: 152 TKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGV 211
Query: 169 HVSTIDPHIIKTGMANSNS 187
+ + P+ + TG + S
Sbjct: 212 KTTCLCPNFVNTGFIKNPS 230
>At3g47350 [Q] KOG1205 Predicted dehydrogenase
Length = 308
Score = 79.7 bits (195), Expect = 4e-15
Identities = 70/225 (31%), Positives = 108/225 (47%), Gaps = 34/225 (15%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYE-------------VFGTSRK-GS-----IPGKEY 44
+V+LITGAS+GIG +A G + V TSR+ GS IPG
Sbjct: 47 KVVLITGASSGIGEHVAYEYAKKGAKLALVARRKDRLEIVAETSRQLGSGDVIIIPG--- 103
Query: 45 SFKMIKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETN 104
D+++ E K ++E I G++D L+NNAG+ + A +I + N
Sbjct: 104 -------DVSNVEDCKKFIDETIHHFGKLDHLINNAGVPQTVIFEDFTQIQDANSIMDIN 156
Query: 105 FFGVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVK 164
F+G +T +PH+R+ + GKI+ ISS I+P+ ++Y +SK AL + E+L E+
Sbjct: 157 FWGSTYITYFAIPHLRKSK-GKIVVISSATAIIPLQAASVYSASKAALVKFFETLRVEIS 215
Query: 165 KFGIHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLK 209
I ++ P I T M +P +EM D I + R K
Sbjct: 216 P-DIKITIALPGFISTDM---TTPQFKEMYGSDFILSESVSRCAK 256
>At3g46170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 288
Score = 79.7 bits (195), Expect = 4e-15
Identities = 61/194 (31%), Positives = 98/194 (50%), Gaps = 14/194 (7%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK-----------GSIPGKEYSFKMI 49
+K +V+L+TGAS+GIG I L AG ++ +R+ S +
Sbjct: 26 LKDKVVLVTGASSGIGREICLDLGKAGCKIIAVARRVDRLNSLCSEINSSSSTGIQAAAL 85
Query: 50 KLDIT-DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
KLD+T D +++ V G+ID L+NNAGI + + S + +F+TN G
Sbjct: 86 KLDVTSDAATIQKVVQGAWGIFGKIDALINNAGIRGNVKSSLDLSKEEWDNVFKTNLTGP 145
Query: 109 HRMTRAVLPHMREQR-HGKIINISSMGGIMPIPYGAL-YCSSKHALEGYTESLDYEVKKF 166
+++ V MR+ + G +INISS+ GI I GAL Y SK ++ ++ + E+
Sbjct: 146 WLVSKYVCVLMRDAKLGGSVINISSIAGIRGILPGALAYACSKIGVDTMSKMMAVELGVH 205
Query: 167 GIHVSTIDPHIIKT 180
I V++I P I K+
Sbjct: 206 KIRVNSIAPGIFKS 219
>At1g54870 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 79.0 bits (193), Expect = 7e-15
Identities = 59/194 (30%), Positives = 92/194 (47%), Gaps = 17/194 (8%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIP-GKEYSFKMIK---------- 50
K +V LITG +GIG ++ S G V T KG + + +M+K
Sbjct: 34 KLRVALITGGDSGIGRAVGYCFASEGATVAFTYVKGQEEKDAQETLQMLKEVKTSDSKEP 93
Query: 51 ----LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFF 106
D+ +E+ K V+EV+ GRIDVL+NNA ++ + +EE + +F TN F
Sbjct: 94 IAIPTDLGFDENCKRVVDEVVNAFGRIDVLINNAAEQYESSTIEEIDEPRLERVFRTNIF 153
Query: 107 GVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKF 166
+TR L HM+E IIN +S+ Y ++K A+ +T L ++ +
Sbjct: 154 SYFFLTRHALKHMKE--GSSIINTTSVNAYKGNASLLDYTATKGAIVAFTRGLALQLAEK 211
Query: 167 GIHVSTIDPHIIKT 180
GI V+ + P I T
Sbjct: 212 GIRVNGVAPGPIWT 225
>7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 321
Score = 79.0 bits (193), Expect = 7e-15
Identities = 55/190 (28%), Positives = 92/190 (47%), Gaps = 14/190 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR---KGSIPGKEYSFK------MIKLDITDEE 57
++TG++ GIG + A+ L G ++ SR K ++ KE K +I +D T +
Sbjct: 56 VVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGD 115
Query: 58 SVKSAVNEVIEKAGRIDVLVNNAGIAFK----WAAVEECSTDLAKTIFETNFFGVHRMTR 113
+ + E + VLVNN GI++ + + + I N V MT
Sbjct: 116 EIYDKIREKTTGLN-VGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTHMTA 174
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
LP M QR G IIN+SS G++P P ++Y S+K + +++ L E K+ GI + ++
Sbjct: 175 LFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQSV 234
Query: 174 DPHIIKTGMA 183
P + T M+
Sbjct: 235 QPGFVATNMS 244
>7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 336
Score = 78.6 bits (192), Expect = 9e-15
Identities = 68/235 (28%), Positives = 105/235 (43%), Gaps = 26/235 (11%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSR-----KGSIPGKEY-------SFKMIKLDI 53
+++TG S GIGL +A G V +R G++ E F+ LDI
Sbjct: 38 VVVTGGSKGIGLCLAVECAMKGANVTVIARDEKMLSGAVALMEVIRQRPDQKFQYRSLDI 97
Query: 54 T-DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+ D + V + E+ + G I L+N AG+A EE S + NFFG + T
Sbjct: 98 SGDYDQVAKVLGEIEDSFGPIYTLINCAGMAI-CGVFEEVSVQDVHKLMNVNFFGTYNCT 156
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
R VLP M++ G I+ +S + I Y ++K+AL E++ E ++ G+ V+
Sbjct: 157 RYVLPKMKKAGDGIIVITASQAAMFGIYGYGPYSATKYALRAMAETIAMESREHGVSVTL 216
Query: 173 IDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLK 227
P ++N+P EE K K E + EPEV+AK +LK
Sbjct: 217 AMP-------CDTNTPGFEE-----EEKSKPRETKIISGGGGLIEPEVMAKAILK 259
>7295487 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 317
Score = 78.6 bits (192), Expect = 9e-15
Identities = 54/199 (27%), Positives = 96/199 (48%), Gaps = 11/199 (5%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRK--------GSIPGKEYSFKMIKLDITD 55
+V ++T ++ GIG +IA+ L G V +SRK + + +K +++
Sbjct: 72 KVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHVSE 131
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E K E I K G++++LV+NA V EC + IF+ N + + +
Sbjct: 132 PEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKSSYLLAKEA 191
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
LP +R+Q++ I+ +SS+ G Y SK AL G T++ ++ GI V+ + P
Sbjct: 192 LPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCLAP 251
Query: 176 HIIKTGMANS---NSPADE 191
+I+T + + N A+E
Sbjct: 252 GVIRTKFSKALYENESANE 270
>7292613 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 78.6 bits (192), Expect = 9e-15
Identities = 73/250 (29%), Positives = 122/250 (48%), Gaps = 42/250 (16%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK--------GSIPGKEYSFKMIKL-- 51
+ +V ++TGAS+GIG +IA+ L AG V G +R+ +P ++ K+ L
Sbjct: 5 QNRVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRVKELQRELPAEKRG-KLFALYC 63
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
D+ +E SV A + +I+K G IDVLVNNAG + + + + + + + +TN G+
Sbjct: 64 DVGNESSVNEAFDWIIQKLGAIDVLVNNAG-TLQPGYLVDMNPAVMQQVLQTNIMGIVLC 122
Query: 112 TRAVLPHMREQR-HGKIINISSMGGIMPI-------PYGALYCSSKHALEGYTESLDYEV 163
T+ + MRE++ G ++ I+S+ G + P +Y SKHA+ E E
Sbjct: 123 TQRAVRSMRERKFDGHVVLINSILGHKTMTATEGVAPDVNVYPPSKHAVTALAEGYRQEF 182
Query: 164 KKFG--IHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVI 221
G I ++++ P ++ T + V DSI+ + +RML E I
Sbjct: 183 FGLGTRIKITSVSPGVVDTEI------------VPDSIREAIKDRML--------HSEDI 222
Query: 222 AKEVLKVIKT 231
A+ VL I T
Sbjct: 223 AQGVLYAIAT 232
>SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase
Length = 247
Score = 78.2 bits (191), Expect = 1e-14
Identities = 73/245 (29%), Positives = 119/245 (47%), Gaps = 27/245 (11%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEY-------SFKMIKLDITD 55
++VIL+TG+S GIGL+ AE L+ +V SR + P E SF +K D+T
Sbjct: 6 EKVILLTGSSKGIGLATAEALQKKA-KVIAVSRSLT-PELETLLIQNPDSFVHVKGDVT- 62
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E K+++ I+K G++D ++ NAG+ A + + + + +F+ NFF V +
Sbjct: 63 -EVGKASIETAIKKFGKLDSVILNAGVLEPIAKIADADINEWRKLFDINFFSVVETVKYA 121
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
+PH+R+ + G I+ +SS + P A YC SK A+ +L E + I + P
Sbjct: 122 IPHLRKTK-GTIVIVSSGAAVRVFPAWAAYCCSKAAINMLVMNLGSE--EPDIMSVAVRP 178
Query: 176 HIIKTGMANS--NSPADEEMAVYDSIKGKVSERMLKQSLENSDE---PEVIAKEVLKVIK 230
++ T M S N E M G + K+ L+ S + P+ IAK + +
Sbjct: 179 GVVDTPMQVSIRNDSNKEAM-------GGDTHNFFKE-LKTSGQLVAPQDIAKALSFLAL 230
Query: 231 TENPK 235
NPK
Sbjct: 231 NNNPK 235
>Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 332
Score = 78.2 bits (191), Expect = 1e-14
Identities = 64/236 (27%), Positives = 108/236 (45%), Gaps = 28/236 (11%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIPGKEYSFKMIKLDIT--- 54
+++TG S+GIG IA G + +R K I + K + L I+
Sbjct: 35 VVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDV 94
Query: 55 --DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
D V++ + + EK G +D+LVN AG+A E+ + + N+ G +
Sbjct: 95 SQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVS-GKFEDLEVSTFERLMSINYLGSVYPS 153
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
RAV+ M+E+R G+I+ +SS G + + Y +SK A+ G E+L EVK + ++++
Sbjct: 154 RAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITV 213
Query: 173 IDPHIIKT-GMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLK 227
P T G A N + K E L + +PE +AK+++K
Sbjct: 214 AYPPDTDTPGFAEEN-------------RTKPLETRLISETTSVCKPEQVAKQIVK 256
>CE21093 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 281
Score = 78.2 bits (191), Expect = 1e-14
Identities = 61/210 (29%), Positives = 99/210 (47%), Gaps = 23/210 (10%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIK 50
+V L+TG+S GIG + A G +V T R K +P E +
Sbjct: 8 KVALVTGSSNGIGRAAAVLFAKDGAKVTVTGRNAERLEETRQEILKSGVP--ESHVLSVA 65
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAF---KWAAVEECSTDLAKTIFETNFFG 107
D+ E+ VN I+K GR+D+LVNNAG AF + + + I + N
Sbjct: 66 TDLAAEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDKIMQINMRS 125
Query: 108 VHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGAL-YCSSKHALEGYTESLDYEVKKF 166
V +T+ H+ + + G+I+N+SS+ G G + Y SK AL+ +T ++ ++
Sbjct: 126 VVTLTQKAKEHLVKAK-GEIVNVSSIAGTAHAQPGVMYYAMSKSALDQFTRCAAIDLIQY 184
Query: 167 GIHVSTIDPHIIKTGMANS---NSPADEEM 193
G+ V+++ P + TG + S A EEM
Sbjct: 185 GVRVNSVSPGGVTTGFGEAMGMPSGAFEEM 214
>CE07539 [Q] KOG1205 Predicted dehydrogenase
Length = 537
Score = 78.2 bits (191), Expect = 1e-14
Identities = 67/268 (25%), Positives = 123/268 (45%), Gaps = 36/268 (13%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIK---------- 50
+K ++++ITGAS+G+G S+A L G +V +R KE ++ K
Sbjct: 76 VKNKIVVITGASSGLGKSLAFELYKRGAQVILLARSTE-KLKEICAELTKTFPLNKNKPT 134
Query: 51 ---LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFG 107
DIT+ + A + ++DVL+NNAG++ + + ++ + + + ETN FG
Sbjct: 135 YYFFDITNPDKAPWA------QIPKVDVLINNAGMSNR-GSCQDTTMAIHRKAMETNLFG 187
Query: 108 VHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFG 167
++T+++L + G I+ SS+ G + IPY Y +SKHAL+GY + L E K
Sbjct: 188 HVQVTQSLLSKLSPD--GCIVVTSSIQGKVAIPYRGSYSASKHALQGYFDCLRAEHK--N 243
Query: 168 IHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLK 227
+H+ + I TG + D ++ + ++ + PE A+ +
Sbjct: 244 LHILVVSAGYINTGFGSRALDTDGKVVGVED-----------ENQKKGYSPEHSARMISD 292
Query: 228 VIKTENPKSRYTPGKAKLYAYFSYYTPS 255
I+ P A+ + Y+ P+
Sbjct: 293 AIRDRVSDFDMAPFGARFAIFLRYFWPT 320
>At3g42960 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 272
Score = 77.8 bits (190), Expect = 1e-14
Identities = 52/182 (28%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVFGTS---RKGSIPGKEYSFKMIKLDITDEESV 59
++V +ITG + GIG + A G V +G + + + D++ E V
Sbjct: 10 EKVAIITGGARGIGAATARLFTENGAYVIVADILENEGILVAESIGGCYVHCDVSKEADV 69
Query: 60 KSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV-HRMTRAVLPH 118
++AV + + GR+DV+ NNAG++ ++ D+ + N GV H + A
Sbjct: 70 EAAVELAMRRKGRLDVMFNNAGMSLNEGSIMGMDVDMVNKLVSVNVNGVLHGIKHAAKAM 129
Query: 119 MREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHII 178
++ R G II SS G+M G Y SK A+ G + E+ GI V++I PH +
Sbjct: 130 IKGGRGGSIICTSSSSGLMGGLGGHAYTLSKGAINGVVRTTACELGSHGIRVNSISPHGV 189
Query: 179 KT 180
T
Sbjct: 190 PT 191
>At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 327
Score = 77.8 bits (190), Expect = 1e-14
Identities = 73/243 (30%), Positives = 114/243 (46%), Gaps = 25/243 (10%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKLDITDEESVK 60
+K + ITG S+GIGL++A S G V +R GS E + K I+L E +
Sbjct: 37 IKSRHAFITGGSSGIGLALAHRAASEGARVSILARSGS--KLEEAKKSIQLATGVEVATF 94
Query: 61 SA-------VNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
SA V++ I+++G IDVL+ N G+ V+ D+ TI + N G + +
Sbjct: 95 SADVRDYDAVSKAIDESGPIDVLIVNQGVFTAKELVKHSPEDVKFTI-DVNLVGSFNVIK 153
Query: 114 AVLPHMREQRH---GKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV 170
A LP M+ ++ I +SS G + + A Y +SK L+G ++L EV IHV
Sbjct: 154 AALPAMKARKDRGPASISLVSSQAGQVGVYGYAAYSASKFGLQGLAQALQQEVISDDIHV 213
Query: 171 STIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVIK 230
+ I P ++N+P EE K + + + S E E +AK+ + IK
Sbjct: 214 TLIFP-------PDTNTPGFEE-----EQKSRPEVTAIIAASSGSMETEEVAKKAMDGIK 261
Query: 231 TEN 233
N
Sbjct: 262 AGN 264
>SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 77.4 bits (189), Expect = 2e-14
Identities = 68/244 (27%), Positives = 118/244 (47%), Gaps = 21/244 (8%)
Query: 4 QVILITGASTGIGLSIAETLRSA-GYEVFGTSRKGSIP------GKEYS-FKMIKLDITD 55
++ I G + GIGLS+ + L + G VF ++RK K +S +IKLDI+
Sbjct: 6 KIYFIAGGNRGIGLSLVKELSNREGTVVFASARKPEAATELQEWSKSHSNVHIIKLDISS 65
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
ES A EV + G++DVL N+GI + V D+ + ++TN G + +A
Sbjct: 66 LESANEAAQEVAKAVGKVDVLWVNSGIFHSFNTVLNTPDDVWNSHYKTNVLGPIHVYQAF 125
Query: 116 LPHMREQRHGKIINISSMGGIMP--IPYG-ALYCSSKHALEGYTESLDYEVKKFGIHVST 172
P +++ I+ SS+ G M P+ + Y SK AL + + +E++ G V +
Sbjct: 126 YPLVKKGESKIIVFTSSLVGSMGAFFPFNQSGYGQSKAALNFTMKEISFELQDEGFIVIS 185
Query: 173 IDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVIKTE 232
I P +++T A E + + K ++ + KQ+L P+ A ++LKV+
Sbjct: 186 IHPGMVRT------DSAQEAVNQHAEAKPEILDIFAKQAL----APDQSASDMLKVVDNL 235
Query: 233 NPKS 236
P++
Sbjct: 236 KPEN 239
>CE12990 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 77.4 bits (189), Expect = 2e-14
Identities = 55/188 (29%), Positives = 93/188 (49%), Gaps = 14/188 (7%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSRKGSI--PGKEYSFKMIKL---------DIT 54
++ITG+S+GIG + A G +V T R K+ K++K ++T
Sbjct: 9 VIITGSSSGIGRATAVLFAKNGAQVTITGRNAEKLEATKKKLLKVVKTPDSVNVVVANLT 68
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVE-ECSTDLAKTIFETNFFGVHRMTR 113
D + + ++K G+ID+L+NNAG V + S DL F+ NF V M +
Sbjct: 69 DAQGQDQIIQSAVKKFGKIDILINNAGANVVDGTVNTDQSIDLYHKTFQINFQAVVEMVK 128
Query: 114 AVLPHMREQRHGKIINISSM-GGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
++ E + G+I+N+SS+ G + Y ++K AL YT + ++ K G+ V++
Sbjct: 129 KTKKYLIESK-GEIVNVSSIAAGPQAVSMSPYYAAAKAALNQYTRCVALDLIKQGVRVNS 187
Query: 173 IDPHIIKT 180
+ P II T
Sbjct: 188 VSPGIIAT 195
>7300831 [Q] KOG1205 Predicted dehydrogenase
Length = 248
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/207 (30%), Positives = 103/207 (49%), Gaps = 17/207 (8%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIPGKEYSFKMIKLDI 53
+ +V ++TGAS GIG + A L +AG V G +R + + G F + D+
Sbjct: 8 RNKVAVVTGASVGIGATTAIELANAGMVVVGLARRVELIEALRDQVTGVGKIFAR-QCDL 66
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
DEE + SA N + EK I VL+ NAGI K + E T K +F+TN R
Sbjct: 67 NDEEQLASAFNWIREKFQAIHVLICNAGI-LKANFLSESPTKDIKELFDTNVVATASCLR 125
Query: 114 AVLPHMREQR-HGKIINISSMGG----IMPIPYGALYCSSKHALEGYTESLDYEVK--KF 166
L HM + G I+ ++S+ G +P+P ++Y ++KHA+ +++ E+ K
Sbjct: 126 EALKHMAAVKVRGHIVVMNSVLGHRIPEVPVPLFSVYPATKHAITALCQTVRQEIHFLKL 185
Query: 167 GIHVSTIDPHIIKTGMANSNSPADEEM 193
I +++I P ++ T + S A E+
Sbjct: 186 NIKLTSICPGMVDTDFLSVYSQAVAEL 212
>CE19894 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 77.0 bits (188), Expect = 3e-14
Identities = 62/189 (32%), Positives = 90/189 (46%), Gaps = 9/189 (4%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR--KGSIPGKEY-------SFKMIKLDIT 54
+V ++T A+ GIGL+IAE L G V SR K EY I I
Sbjct: 11 KVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAGHIA 70
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
+ K V+ ++K G+I++LVNN GI + + E S + +FE N +MT+
Sbjct: 71 STDDQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQMTKL 130
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
V PH+ ++ G II +S P A Y +K L G T +L + K I V+ I
Sbjct: 131 VHPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIRVNGIA 190
Query: 175 PHIIKTGMA 183
P +IKT M+
Sbjct: 191 PGVIKTKMS 199
>CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 307
Score = 77.0 bits (188), Expect = 3e-14
Identities = 54/188 (28%), Positives = 89/188 (46%), Gaps = 12/188 (6%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEV--FGTSRKGSIPGKEYSFKM------IKLDITDEE 57
+LITG+ +GIG +A G EV + ++ G+ K K +D++ +
Sbjct: 42 VLITGSGSGIGRLMALEFAKLGAEVVIWDVNKDGAEETKNQVVKAGGKASTFVVDLSQYK 101
Query: 58 SVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLP 117
+ E E G ID+L+NNAGI + +C +L + N + + LP
Sbjct: 102 DIHKVAKETKEAVGDIDILINNAGIV-TGKKLFDCPDELMEKTMAVNTNALFYTAKNFLP 160
Query: 118 HMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV---KKFGIHVSTID 174
M E+ +G ++ I+SM G YC+SKH G +S+ E+ KK+G++ + +
Sbjct: 161 SMLEKDNGHLVTIASMAGKTGCVGLVDYCASKHGAIGCHDSIAMEILAQKKYGVNTTLVC 220
Query: 175 PHIIKTGM 182
P I TGM
Sbjct: 221 PFFIDTGM 228
>CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 76.3 bits (186), Expect = 4e-14
Identities = 54/226 (23%), Positives = 104/226 (45%), Gaps = 12/226 (5%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVF--------GTSRKGSIPGKEYSFKMIKLDIT 54
++ +LITGA G+G +A+ + G + K I G + ++++
Sbjct: 40 RKKVLITGAGNGLGKLLAQKFAARGATLILWDINLQSVDELKNEIRGNQGEAHSYEVNLC 99
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
D + +VI G++D+LVNNAGIA ++ ++ ++ F+ N +
Sbjct: 100 DPGKIAQVGQQVINDIGKVDILVNNAGIATAKMILDSSENEINRS-FDVNVKAHFYTVQQ 158
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV---KKFGIHVS 171
LP M + +G I+ I+S G M A Y S+KHA G+ +SL E+ +K G+ +
Sbjct: 159 FLPAMLKDNNGHIVTIASAAGKMGSSGLADYSSTKHAAVGFHDSLVAEIMESEKNGVKTT 218
Query: 172 TIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDE 217
+ P+ + T M ++ A ++ + + + +++E E
Sbjct: 219 LVCPYYVHTSMFDATGAATRFPWIFPILDTDYVVQKIFEAIETEQE 264
>CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 368
Score = 75.9 bits (185), Expect = 6e-14
Identities = 66/281 (23%), Positives = 119/281 (41%), Gaps = 32/281 (11%)
Query: 1 MKKQVILITGASTGIGLSIA------------ETLRSAGYEVFGTSRKGSIPGKEYSFKM 48
+ K+ + ITG +G G +A L G E + SI G S
Sbjct: 67 LSKRAVFITGCDSGFGRGLALKCLEQGMPVFAGCLTEQGIESLSAEARKSI-GNGRSLDA 125
Query: 49 IKLDITDEESVKSAVNEVIEKA---GRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNF 105
+D+T +ESV + +K G + +VNNAGI K A + + + N
Sbjct: 126 FLMDVTSDESVGEVAKRLEKKCEQYGGLHAVVNNAGITGKHIADDFLDINEYLKVANINL 185
Query: 106 FGVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKK 165
+G R T AV +++ R G+++ ++S+ + +P Y SK+ + Y + + E++
Sbjct: 186 WGPIRTTMAVKKLLKKAR-GRVVTVASICARVGLPGLGPYSVSKYGVSAYCDVIRQELRP 244
Query: 166 FGIHVSTIDPHIIKTGMANSNSPADEEMAVY----DSIKGKVSERMLKQSLEN------- 214
FGI V ++P T + N E + + + +K + E+ + E+
Sbjct: 245 FGISVHVLEPGFFNTPLINREKIDAEILEAWKHAPNEVKQEYGEKFFNDARESTHLFLNS 304
Query: 215 --SDEPEVIAKEVLKVIKTENPKSRYTPG--KAKLYAYFSY 251
S + ++ I +++P+SRY G L+ FSY
Sbjct: 305 VASSQISLVVDAYFHAITSKHPRSRYQIGWDSILLFIPFSY 345
>CE12594 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 75.5 bits (184), Expect = 7e-14
Identities = 53/191 (27%), Positives = 94/191 (48%), Gaps = 18/191 (9%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIKLD 52
I+ITG+S+GIG S A G +V T R K +P ++ + + D
Sbjct: 9 IIITGSSSGIGRSAAVIFAKEGAQVTITGRSADRLEETRLQILKAGVPAEKIN--AVVAD 66
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAG-IAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
+ + + + K G+ID+LVNNAG + + + + +L + F+ NF V M
Sbjct: 67 VCEASGQDEVIRTTLAKFGKIDILVNNAGALLTDGTSNTDQAVELYQKTFKLNFQAVVEM 126
Query: 112 TRAVLPHMREQRHGKIINISSM-GGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV 170
T+ ++ + + G+I+N+SS+ G P Y +K AL+ YT ++ + G+ V
Sbjct: 127 TQKTKEYLIKTK-GEIVNVSSIVAGPQAQPASPYYACAKAALDQYTRCTAIDLIQHGVRV 185
Query: 171 STIDPHIIKTG 181
+++ P +I TG
Sbjct: 186 NSVSPGVIATG 196
>CE21092 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 75.1 bits (183), Expect = 1e-13
Identities = 54/203 (26%), Positives = 91/203 (44%), Gaps = 16/203 (7%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSI-----------PGKEYSFKMIKLD 52
+V +ITG+S+GIG S A L G +V T R G + ++ D
Sbjct: 7 KVAIITGSSSGIGRSTAVLLAQEGAKVTVTGRSSEKIQETVNEIHKNGGSSDNINIVLGD 66
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAF---KWAAVEECSTDLAKTIFETNFFGVH 109
+ + E + + + G+ID+L+NNAG AF E + + + + N V
Sbjct: 67 LNESECQDELIKSTLSRFGKIDILINNAGAAFADPSGKIGSEAAIGIFDDMMKLNLRSVV 126
Query: 110 RMTRAVLPHMREQRHGKIINISSM-GGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
+ + PH+ + G+I+N+SS+ G P Y Y K L+ T SL E+ F +
Sbjct: 127 ELVKKCRPHLIASK-GEIVNVSSIAAGPQPYIYYTYYGICKAGLDQLTRSLALELIPFDV 185
Query: 169 HVSTIDPHIIKTGMANSNSPADE 191
V+++ P +I T + D+
Sbjct: 186 RVNSVSPGLISTNFLGAVGMGDD 208
>CE14538 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 75.1 bits (183), Expect = 1e-13
Identities = 60/223 (26%), Positives = 100/223 (43%), Gaps = 28/223 (12%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIK 50
+V ++TG+S GIG + A L S G +V T R K +P + +
Sbjct: 8 EVAIVTGSSNGIGRATAILLASEGAKVTITGRNAERLEESRQALLKVGVPSGHIN--SVV 65
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAF---KWAAVEECSTDLAKTIFETNFFG 107
D+T ++ ++K G+I++L+NNAG + + F+ NF
Sbjct: 66 ADVTTGAGQDVLIDSTLKKFGKINILINNAGALIVDPEGKTNTSTGVETCLKTFQLNFQS 125
Query: 108 VHRMTRAVLPHMREQRHGKIINISSMG----GIMPIPYGALYCSSKHALEGYTESLDYEV 163
V MT+ + PH+ HG+I+N+SS+G PY Y ++K AL+ Y+ + ++
Sbjct: 126 VVEMTQKIRPHL-ANTHGEIVNVSSVGAGPAAENRFPY---YSAAKAALDQYSRNTAIDL 181
Query: 164 KKFGIHVSTIDPHIIKTGM--ANSNSPADEEMAVYDSIKGKVS 204
GI V+ + P + TG A S D +Y+ I S
Sbjct: 182 IPDGIRVNIVQPGFVATGFTTAASGMSPDASAKMYEGIGANTS 224
>At5g50590 [Q] KOG1205 Predicted dehydrogenase
Length = 299
Score = 75.1 bits (183), Expect = 1e-13
Identities = 57/198 (28%), Positives = 100/198 (49%), Gaps = 11/198 (5%)
Query: 4 QVILITGASTGIGLSIA-ETLRSAGYEVFGTSRKGSIPGKEYSFK--------MIKLDIT 54
+V++ITG+S+GIG +A E R Y R+ + + +++ D++
Sbjct: 48 KVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGDVS 107
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
+ K V E I + GR+D LVNNAGIA + I TNF+G T
Sbjct: 108 VIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGPVYATHF 167
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
+PH+++ + GKII ++S G +P ++Y +SK A+ + E+L E+ + V+ +
Sbjct: 168 AIPHLKKTK-GKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIELHP-EVGVTIVF 225
Query: 175 PHIIKTGMANSNSPADEE 192
P +I+ G N + A+++
Sbjct: 226 PGLIENGNTNPDLLAEKQ 243
>YIR035c [Q] KOG1204 Predicted dehydrogenase
Length = 254
Score = 74.7 bits (182), Expect = 1e-13
Identities = 67/238 (28%), Positives = 112/238 (46%), Gaps = 25/238 (10%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYE--VFGTSRKGSIPGKEYS------FKMIKLDITD 55
+VIL+TG S GIG SI + L S + V+G +R + P K+ F + DIT+
Sbjct: 3 KVILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEA-PLKKLKEKYGDRFFYVVGDITE 61
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
+ +K VN ++ G+ID LV NAG+ V E + K +++ NFF + +
Sbjct: 62 DSVLKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSLVGIA 121
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
LP ++ + +G ++ +SS M Y SSK AL + +L E ++ + + P
Sbjct: 122 LPELK-KTNGNVVFVSSDACNMYFSSWGAYGSSKAALNHFAMTLANEERQ--VKAIAVAP 178
Query: 176 HIIKTGM-------ANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVL 226
I+ T M +S + E++ ++ +K Q L++S V AK L
Sbjct: 179 GIVDTDMQVNIRENVGPSSMSAEQLKMFRGLKEN------NQLLDSSVPATVYAKLAL 230
>Hs10337605 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/191 (27%), Positives = 93/191 (48%), Gaps = 8/191 (4%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK--------GSIPGKEYSFKMIKLD 52
+ +V L+T ++ GIG +IA L G V +SRK ++ G+ S
Sbjct: 12 LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 71
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+ E + V ++ G ID+LV+NA + + ++ + + ++ + N MT
Sbjct: 72 VGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMT 131
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
+AV+P M ++ G ++ +SS+ P P + Y SK AL G T++L E+ I V+
Sbjct: 132 KAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNC 191
Query: 173 IDPHIIKTGMA 183
+ P +IKT +
Sbjct: 192 LAPGLIKTSFS 202
>At5g50700 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 74.7 bits (182), Expect = 1e-13
Identities = 58/188 (30%), Positives = 102/188 (53%), Gaps = 15/188 (7%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRK-------GSIPGKEYSFKMIKL--DIT 54
+V+LITGAS+GIG +A G + T+R+ I + S ++ + D++
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVS 107
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKT--IFETNFFGVHRMT 112
+ + V++ I GR+D LVNNAG+ ++ E D+ +T + +TNF+G T
Sbjct: 108 KPDDCRRIVDDTITHFGRLDHLVNNAGMT--QISMFENIEDITRTKAVLDTNFWGSVYTT 165
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
RA LP++R Q +GKI+ +SS + P + Y +SK AL + E++ E+ +H++
Sbjct: 166 RAALPYLR-QSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELGG-DVHITI 223
Query: 173 IDPHIIKT 180
+ P I++
Sbjct: 224 VTPGYIES 231
>At5g50600 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 74.7 bits (182), Expect = 1e-13
Identities = 58/188 (30%), Positives = 102/188 (53%), Gaps = 15/188 (7%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRK-------GSIPGKEYSFKMIKL--DIT 54
+V+LITGAS+GIG +A G + T+R+ I + S ++ + D++
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVS 107
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKT--IFETNFFGVHRMT 112
+ + V++ I GR+D LVNNAG+ ++ E D+ +T + +TNF+G T
Sbjct: 108 KPDDCRRIVDDTITHFGRLDHLVNNAGMT--QISMFENIEDITRTKAVLDTNFWGSVYTT 165
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
RA LP++R Q +GKI+ +SS + P + Y +SK AL + E++ E+ +H++
Sbjct: 166 RAALPYLR-QSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELGG-DVHITI 223
Query: 173 IDPHIIKT 180
+ P I++
Sbjct: 224 VTPGYIES 231
>7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 321
Score = 74.7 bits (182), Expect = 1e-13
Identities = 55/192 (28%), Positives = 95/192 (48%), Gaps = 19/192 (9%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMI-----------KLD 52
+V ++TGA G+G +I+ L G + ++ G E + K I K +
Sbjct: 53 EVAVVTGAGHGLGRAISLELAKKGCHIAVVDI--NVSGAEDTVKQIQDIYKVRAKAYKAN 110
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+T+ + + ++V+E+ G + VLVNNAG+ D+ + + N H T
Sbjct: 111 VTNYDDLVELNSKVVEEMGPVTVLVNNAGVMMHRNMFNPDPADV-QLMINVNLTS-HFWT 168
Query: 113 RAV-LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV---KKFGI 168
+ V LP M+E R G I+ ISS+ G+ P+PY A Y ++K + +L E+ + I
Sbjct: 169 KLVFLPKMKELRKGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELDLENQKDI 228
Query: 169 HVSTIDPHIIKT 180
HV+T+ P ++T
Sbjct: 229 HVTTVLPSFLRT 240
>7296706_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 233
Score = 74.7 bits (182), Expect = 1e-13
Identities = 44/148 (29%), Positives = 78/148 (51%), Gaps = 2/148 (1%)
Query: 49 IKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
++ D+T E V+ V + K GRIDVLVNNAGI + ++E S + + TN +
Sbjct: 37 LQADMTKEAEVQQIVGATLAKHGRIDVLVNNAGI-LETGSIEATSLEQFDRLMNTNVRSL 95
Query: 109 HRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
+++T P + + + G I+N+SS+ G+ P Y SK A++ +T + E+ G+
Sbjct: 96 YQLTMLATPELVKTK-GNIVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGV 154
Query: 169 HVSTIDPHIIKTGMANSNSPADEEMAVY 196
V+ ++P +I T + +E A +
Sbjct: 155 RVNAVNPGVIVTDIHKRGGMDEETYAKF 182
>SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 74.3 bits (181), Expect = 2e-13
Identities = 66/244 (27%), Positives = 115/244 (47%), Gaps = 21/244 (8%)
Query: 4 QVILITGASTGIGLSIAETLRSA-GYEVFGTSRKGSIPGK--EYS-----FKMIKLDITD 55
++ I G + GIGLS+ + L + G VF ++RK K E+S +IKLD++
Sbjct: 6 KIYFIAGGNRGIGLSLVKELSNRKGTVVFASARKPGAATKLQEWSKSHSNVHIIKLDVSS 65
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
ES A EV + +DVL N+ + + V D+ + ++TN G + +A
Sbjct: 66 LESANEAAQEVTKVVDAVDVLWVNSAVFHSFGPVVNTPDDVWNSHYKTNVLGPIHVYQAF 125
Query: 116 LPHMREQRHGKIINISSMGGIMPIPY---GALYCSSKHALEGYTESLDYEVKKFGIHVST 172
P +++ R I+ SS+ G M + + Y SK AL + + +E++ G V +
Sbjct: 126 YPLIKKGRSKIIVFTSSLAGSMGAFFPSSQSAYGQSKAALNYTMKEISFELQDEGFIVIS 185
Query: 173 IDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVIKTE 232
I P ++T A E + + K ++ + KQ+L PE A ++LKV+
Sbjct: 186 IHPGAVRT------DSAQEIVNQHAEKKPEILDLFAKQAL----TPEKSASDMLKVVDNL 235
Query: 233 NPKS 236
P++
Sbjct: 236 KPEN 239
>CE05726 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 74.3 bits (181), Expect = 2e-13
Identities = 54/191 (28%), Positives = 91/191 (47%), Gaps = 18/191 (9%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIKLD 52
++ITG+S GIG S A G +V T R K +P ++ + + D
Sbjct: 9 VIITGSSNGIGRSAAVIFAKEGAQVTITGRNEDRLEETKQQILKAGVPAEKIN--AVVAD 66
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAF-KWAAVEECSTDLAKTIFETNFFGVHRM 111
+T+ +N + K G+ID+LVNNAG A + +L + F+ NF V M
Sbjct: 67 VTEASGQDDIINTTLAKFGKIDILVNNAGANLADGTANTDQPVELYQKTFKLNFQAVIEM 126
Query: 112 TRAVLPHMREQRHGKIINISS-MGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV 170
T+ H+ + + G+I+N+SS + G Y +K AL+ YT ++ + G+ V
Sbjct: 127 TQKTKEHLIKTK-GEIVNVSSIVAGPQAHSGYPYYACAKAALDQYTRCTAIDLIQHGVRV 185
Query: 171 STIDPHIIKTG 181
+++ P + TG
Sbjct: 186 NSVSPGAVATG 196
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 74.3 bits (181), Expect = 2e-13
Identities = 57/221 (25%), Positives = 103/221 (45%), Gaps = 22/221 (9%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVFGTSRKG-----------SIPGKEYSFKMIKL 51
++V +ITG+S GIG + A G +V T R + E + +
Sbjct: 6 EKVAIITGSSNGIGRATAVLFAREGAKVTITGRHAERLEETRQQILAAGVSEQNVNSVVA 65
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTI------FETNF 105
D+T + ++ + K G++D+LVNNAG A + + T A++I N
Sbjct: 66 DVTTDAGQDEILSTTLGKFGKLDILVNNAGAAIPDS---QSKTGTAQSIESYDATLNLNL 122
Query: 106 FGVHRMTRAVLPHMREQRHGKIINISSMG-GIMPIPYGALYCSSKHALEGYTESLDYEVK 164
V +T+ +PH+ + G+I+NISS+ G+ P Y +K A++ YT + ++
Sbjct: 123 RSVIALTKKAVPHLSSTK-GEIVNISSIASGLHATPDFPYYSIAKAAIDQYTRNTAIDLI 181
Query: 165 KFGIHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSE 205
+ GI V++I P ++ TG ++ +E + S + E
Sbjct: 182 QHGIRVNSISPGLVATGFGSAMGMPEETSKKFYSTMATMKE 222
>At5g50690 [Q] KOG1205 Predicted dehydrogenase
Length = 303
Score = 74.3 bits (181), Expect = 2e-13
Identities = 58/203 (28%), Positives = 100/203 (48%), Gaps = 11/203 (5%)
Query: 4 QVILITGASTGIGLSIA-ETLRSAGYEVFGTSRKGSIPGKEYSFK--------MIKLDIT 54
+V++ITG+S+GIG +A E R Y R+ + + +++ D++
Sbjct: 48 KVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGDVS 107
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
+ K V E I + GR+D LVNNAGIA + I TNF+G T
Sbjct: 108 VIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGPVYATHF 167
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
+PH+++ + GKII ++S G +P ++Y +SK A+ + E+L E+ + V+ +
Sbjct: 168 AIPHLKKTK-GKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIELHP-EVGVTIVF 225
Query: 175 PHIIKTGMANSNSPADEEMAVYD 197
P +I+ G N + A+ + D
Sbjct: 226 PGLIENGNTNPDLLAESLLQKQD 248
>7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 325
Score = 74.3 bits (181), Expect = 2e-13
Identities = 56/197 (28%), Positives = 96/197 (48%), Gaps = 13/197 (6%)
Query: 4 QVILITGASTGIGLSIAETL-----RSAGYEVFGTSRKGSIPG-KEYSFKMIK---LDIT 54
QV+LITG G+G IA R +++ + K ++ ++ + K +DI+
Sbjct: 57 QVVLITGGGGGVGRLIALNFARLQARIVIWDINQEAIKTTVDLLAKHGYDNCKGYVVDIS 116
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
D E + ++V E+ G +D+L+NNAGI E + + + N + +A
Sbjct: 117 DREQIYQRASQVTEEVGPVDILINNAGIVC-CKPFWELHDRVIQNTYNINIISHYWTVKA 175
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFG---IHVS 171
LPHM G I+ + S+ G++ + Y ++K+A G+ ESL ++K G I +S
Sbjct: 176 FLPHMMRNNRGHIVTVGSVTGMLGTYGCSDYAATKYACIGFHESLLTDLKAHGYDQIQMS 235
Query: 172 TIDPHIIKTGMANSNSP 188
I P+ I TGM + P
Sbjct: 236 LICPYYINTGMFSGVRP 252
>7295621 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 74.3 bits (181), Expect = 2e-13
Identities = 57/195 (29%), Positives = 97/195 (49%), Gaps = 20/195 (10%)
Query: 5 VILITGASTGIGLSIAETLRSAGYEVFGTSRK--------GSIPGKEYS-FKMIKLDITD 55
V ++TGAS+GIG +I L SAG V +R+ +P S ++++ D++D
Sbjct: 8 VAVVTGASSGIGAAITRKLISAGVMVVALARRMDRLEQLREELPQDRRSRLRIMQCDVSD 67
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
SV + + V G +D+L+NNAG + S D + + +TN GV T+
Sbjct: 68 VSSVNAVFDAVQGDLGNVDILINNAG-KLSGGQLLTMSVDTVQQMLQTNVMGVVYCTQRA 126
Query: 116 LPHMRE-QRHGKIINISSMGG---IMPIPYGA----LYCSSKHALEGYTESLDYEVKKF- 166
MR+ Q G ++ I+S+ G P+P +Y ++KHA+ TE E++ F
Sbjct: 127 FESMRQRQSKGHVVLINSIVGHYIFNPLPGSQQELNMYPATKHAITALTELFRQEMRDFK 186
Query: 167 -GIHVSTIDPHIIKT 180
+ V++I P ++ T
Sbjct: 187 TKVKVTSISPGLVDT 201
>At2g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 322
Score = 73.2 bits (178), Expect = 4e-13
Identities = 56/193 (29%), Positives = 90/193 (46%), Gaps = 26/193 (13%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIK--------------LD 52
L+TG + GIG +I E L G EV +R EY + D
Sbjct: 74 LVTGGTRGIGRAIVEELAGLGAEVHTCARN------EYELENCLSDWNRSGFRVAGSVCD 127
Query: 53 ITDE---ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
++D E++ V+ V E G++ +LVNN G + VE + + + T+ TNF V
Sbjct: 128 VSDRSQREALMETVSSVFE--GKLHILVNNVGTNIRKPMVEFTAGEFS-TLMSTNFESVF 184
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
+ + P +RE + G ++ ISS+ G + + ++ S+K A+ T SL E K I
Sbjct: 185 HLCQLAYPLLRESKAGSVVFISSVSGFVSLKNMSVQSSTKGAINQLTRSLACEWAKDNIR 244
Query: 170 VSTIDPHIIKTGM 182
++ + P IKT M
Sbjct: 245 INAVAPWYIKTSM 257
>7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 335
Score = 73.2 bits (178), Expect = 4e-13
Identities = 55/195 (28%), Positives = 101/195 (51%), Gaps = 28/195 (14%)
Query: 3 KQVILITGASTGIGLSIAE--------TLRSAGYEVFGTSRK---GSIPGKEYSFKM--I 49
+ V+LITG +G+G S+A T+ S + + K G K+ +M +
Sbjct: 26 RHVVLITGCDSGLGHSMAVYCHESLHMTVISCCHNIKSEGAKLLQGLASAKDGLSRMHTL 85
Query: 50 KLDITDEESVKSA---VNEVIEK--AGRIDVLVNNAGIA----FKWAAVEECSTDLAKTI 100
+LD+ + +S++ + +++ K + R+ L+NNAG+ F+W E+ +
Sbjct: 86 ELDLLEPDSIRLVHRQLRDILAKDPSYRLTALINNAGVMCFGEFEWQLTEQIEAQI---- 141
Query: 101 FETNFFGVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLD 160
N G R+T +LP +R+Q+ G+IIN++S G+ +P Y +SK AL +T+SL
Sbjct: 142 -NCNLLGTMRLTHELLPLLRQQQ-GRIINVTSHCGLQALPALGPYAASKAALRFWTDSLR 199
Query: 161 YEVKKFGIHVSTIDP 175
E++++G+ V P
Sbjct: 200 VELQQYGMEVVNFIP 214
>7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 339
Score = 73.2 bits (178), Expect = 4e-13
Identities = 55/188 (29%), Positives = 95/188 (50%), Gaps = 9/188 (4%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKG----SIPGK-EYSFKMIKLDITDEES 58
Q ++TGA+ GIG A L G + SR ++ + E +K+ I + +
Sbjct: 71 QWAVVTGATDGIGKEYARELARQGINLVLISRTKEKLIAVTNEIESQYKVKTKWIAADFA 130
Query: 59 VKSAVNEVIEK--AG-RIDVLVNNAGIAFKWA-AVEECSTDLAKTIFETNFFGVHRMTRA 114
V + IEK AG + +LVNN G+ ++ +++ S DL + N V +TR
Sbjct: 131 KGREVYDQIEKELAGIDVGILVNNVGMMYEHPESLDLVSEDLLWNLLTVNMGSVTMLTRK 190
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
+LP M +R G I+N+ S + P+P +Y +SK + ++++L+ EV + IHV +
Sbjct: 191 ILPQMIGRRKGAIVNLGSSSELQPLPNMTVYAASKKFVTYFSKALELEVAEHNIHVQLVM 250
Query: 175 PHIIKTGM 182
P+ + T M
Sbjct: 251 PNFVVTKM 258
>At5g61830 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 72.8 bits (177), Expect = 5e-13
Identities = 46/144 (31%), Positives = 79/144 (53%), Gaps = 13/144 (9%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVFGTSRK--------GSIPGKEYSFKMI--KLD 52
+ V ++TG++ GIG IA L G V T+R S+ +E K+ +LD
Sbjct: 36 ENVAVVTGSNRGIGFEIARQLAVHGLTVVLTARNVNAGLEAVKSLRHQEEGLKVYFHQLD 95
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+TD S++ + + G +D+LVNNAG+ + + + + + A+T+ TN+ G MT
Sbjct: 96 VTDSSSIREFGCWLKQTFGGLDILVNNAGVNYNLGS--DNTVEFAETVISTNYQGTKNMT 153
Query: 113 RAVLPHMREQRHG-KIINISSMGG 135
+A++P MR HG +++N+SS G
Sbjct: 154 KAMIPLMRPSPHGARVVNVSSRLG 177
>At2g30670 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 72.4 bits (176), Expect = 6e-13
Identities = 51/186 (27%), Positives = 92/186 (49%), Gaps = 10/186 (5%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVF-----GTSRKGSIPGKEYSFKMIKLDITD--EESV 59
L+TG ++GIG +I E L G ++ T S+ E + I D S
Sbjct: 13 LVTGGASGIGHAIVEELAGLGARIYVCDISETLLNQSLSEWEKKGFQVSGSICDVSSHSE 72
Query: 60 KSAVNEVIEKA--GRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLP 117
+ + + + K G++++LVNN G+ +E + D + +I TN + +++ P
Sbjct: 73 RETLMQTVSKMFDGKLNILVNNVGVVNPKPTIEYVAADFSFSI-STNLESAYHLSQLSHP 131
Query: 118 HMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHI 177
++ G II ISS+GG++ + G++Y +K AL ++L E + GI +++ P+
Sbjct: 132 LLKASEFGSIIFISSVGGVVSMECGSIYSLTKGALNQLAKTLACEWARDGIRANSVAPNF 191
Query: 178 IKTGMA 183
I T MA
Sbjct: 192 IYTAMA 197
>7296704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 72.4 bits (176), Expect = 6e-13
Identities = 57/204 (27%), Positives = 100/204 (48%), Gaps = 15/204 (7%)
Query: 4 QVILITGASTGIGLSIAETLRSAG--YEVFGTSRKGSIPGKEYSFKM------IKLDITD 55
+V+LITGA++GIG + AE G + +G I + KM I D+
Sbjct: 14 KVVLITGAASGIGAAAAEMFSKLGACLALVDREEEGLICVMKRCMKMGHEPYGIAGDLLK 73
Query: 56 EESVKSAVNEVIEK-AGRIDVLVNNAGIAFKWAAVEECSTDLA--KTIFETNFFGVHRMT 112
++ + E+ G++DVLVN AGI ST+LA + E N +T
Sbjct: 74 PPEIECIARKTTERYEGKLDVLVNGAGIMPTGTLQ---STELACFTHVMEANVRSGFYLT 130
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
+ +LP + + + G I+N+SS+ G+ P Y SK A++ +T SL ++ G+ V+
Sbjct: 131 KLLLPQLLQCK-GSIVNVSSVCGLRAFPNLVAYNMSKAAVDQFTRSLALDLGPQGVRVNA 189
Query: 173 IDPHIIKTGMANSNSPADEEMAVY 196
++P +I+T + + ++ A +
Sbjct: 190 VNPGVIRTNLQKAGGMDEQSYAEF 213
>SPAC922.06 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 72.0 bits (175), Expect = 8e-13
Identities = 56/181 (30%), Positives = 93/181 (50%), Gaps = 14/181 (7%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKM-IKLDITDEESVKSA 62
+V+LITGA+ GIG + + G V G P K + ++ D++ + +++A
Sbjct: 6 RVVLITGAAGGIGKVLCKMFTELGDRVAGIDIVD--PSKVQDAALALQADVSKADQIETA 63
Query: 63 VNEVIEKAGRIDVLVNNAGIA----FKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPH 118
+ +VI+ G IDVL+NNAG+A F+ + E D++ + G + R V+PH
Sbjct: 64 IEKVIQTLGPIDVLINNAGLADDTPFEQLSHESWDHDVSLVL-----RGNYLTQRYVIPH 118
Query: 119 MREQ-RHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHI 177
M +Q + G I+NI S+ G + + A Y ++K LE T++L GI V+ P
Sbjct: 119 MAKQGKGGSIVNIGSVNGHIYLGSPA-YSAAKAGLENLTKALAVRYGPLGIRVNVCAPGT 177
Query: 178 I 178
I
Sbjct: 178 I 178
>Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 341
Score = 71.6 bits (174), Expect = 1e-12
Identities = 44/134 (32%), Positives = 68/134 (49%), Gaps = 4/134 (2%)
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
D+ E+V V ++ G + VLVNNAG+ +E C +L + N
Sbjct: 118 DVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLE-CPDELIERTMMVNCHAHFWT 176
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVK---KFGI 168
T+A LP M E HG I+ ++S G+ YC+SK + G+ ESL +E+K K GI
Sbjct: 177 TKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGI 236
Query: 169 HVSTIDPHIIKTGM 182
+ + P+++ TGM
Sbjct: 237 KTTLVCPYLVDTGM 250
>Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 309
Score = 71.6 bits (174), Expect = 1e-12
Identities = 53/191 (27%), Positives = 84/191 (43%), Gaps = 21/191 (10%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKLDITDEESVKSAVNEV 66
+++GA+ GIG + AE L S G + SR E +++ DI D V++ +
Sbjct: 50 VVSGATDGIGKAYAEELASRGLNIILISRN------EEKLQVVAKDIADTYKVETDIIVA 103
Query: 67 IEKAGR--------------IDVLVNNAGIAFKWAAV-EECSTDLAKTIFETNFFGVHRM 111
+GR + +LVNN G+ + + + S D I N M
Sbjct: 104 DFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLM 163
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVS 171
VLP M E++ G I+ ISS P P A + +SK L+ ++ +L YE GI V
Sbjct: 164 VHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQ 223
Query: 172 TIDPHIIKTGM 182
++ P + M
Sbjct: 224 SLIPFYVAASM 234
>At3g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 259
Score = 71.6 bits (174), Expect = 1e-12
Identities = 58/215 (26%), Positives = 98/215 (44%), Gaps = 11/215 (5%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEV--------FGTSRKGSIPGKEYSFKMIKLDITD 55
++++ITG ++GIG A G +V G + SI + SF + DITD
Sbjct: 9 KIVIITGGASGIGAEAARLFTDHGAKVVIVDLQEELGQNVAVSIGLDKASF--YRCDITD 66
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR-A 114
E V++AV +EK G++DVL +NAG+ ++ + + N G + A
Sbjct: 67 ETEVENAVKFTVEKHGKLDVLFSNAGVMEPHGSILDLDLEAFDRTMAVNVRGAAAFIKHA 126
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
+ G I+ +S+ + P Y +SKHAL G S + K+GI V+ +
Sbjct: 127 ARSMVASGTRGSIVCTTSVTAEIGGPGPHSYTASKHALLGLVRSACGGLGKYGIRVNGVA 186
Query: 175 PHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLK 209
P+ + TG+ + N + + Y S + +LK
Sbjct: 187 PYGVATGLTSYNEETVKMVEDYCSATAILKGVVLK 221
>7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 361
Score = 71.2 bits (173), Expect = 1e-12
Identities = 44/170 (25%), Positives = 84/170 (48%), Gaps = 10/170 (5%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYE--VFGTSRKGSIPGKEYSFKM-------IKLDIT 54
+V L+TG +G+G I L G + V + KG E K+ K D++
Sbjct: 93 KVALVTGGGSGLGREICLELARRGCKLAVVDVNSKGCYETVELLSKIPRCVAKAYKNDVS 152
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
++ +V ++ G +D+LVNNA + + +D TI + N T+
Sbjct: 153 SPRELQLMAAKVEKELGPVDILVNNASL-MPMTSTPSLKSDEIDTILQLNLGSYIMTTKE 211
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVK 164
LP M ++ G ++ ++++ G++P+P +Y ++K+ +EG+ ESL E++
Sbjct: 212 FLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAELR 261
>CE26808_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 550
Score = 71.2 bits (173), Expect = 1e-12
Identities = 57/200 (28%), Positives = 95/200 (47%), Gaps = 22/200 (11%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIK 50
+V L+TG+S GIG + A G +V T R K +P + + I
Sbjct: 222 KVALVTGSSNGIGRAAALLFAQQGAKVTITGRNAERLEETRQAILKSGVPAE--NVLAIA 279
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFK----WAAVEECSTDLAKTIFETNFF 106
D+ ++ +N ++K GR+D+LVNNAG A +++ D KT F+ N
Sbjct: 280 ADLATDQGQTDLINGTLQKFGRLDILVNNAGAAVNDPQGRMGIDQQIEDFDKT-FQINMR 338
Query: 107 GVHRMTRAVLPHMREQRHGKIINISSM-GGIMPIPYGALYCSSKHALEGYTESLDYEVKK 165
V + + H+ + + G+IIN+SS+ GG P Y SK AL+ +T S + +
Sbjct: 339 SVVTLVQKAKEHLIKTK-GEIINVSSIGGGPHAQPDMMYYGMSKAALDQFTRSTAITLIQ 397
Query: 166 FGIHVSTIDPHIIKTGMANS 185
G+ V+++ P + TG +
Sbjct: 398 HGVRVNSVSPGGVYTGFGEA 417
>Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 179
Score = 70.5 bits (171), Expect = 2e-12
Identities = 49/180 (27%), Positives = 86/180 (47%), Gaps = 12/180 (6%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRK--------GSIPGKEYSFKMIKLDITD 55
+V + G S GIG ++A+ + GY + +R G + G +F D+
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSC---DVAK 59
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E V++ E+ + GR++ LVN AGI V + D+ + TN G +A
Sbjct: 60 EHDVQNTFEEMEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQL-HTNLLGSMLTCKAA 118
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
+ M +Q+ G I+N+ S+ G+ ++Y +SK L G++ +L EV + I V+ + P
Sbjct: 119 MRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAP 178
>7297069 [Q] KOG1205 Predicted dehydrogenase
Length = 246
Score = 70.5 bits (171), Expect = 2e-12
Identities = 58/201 (28%), Positives = 99/201 (48%), Gaps = 19/201 (9%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKG--------SIPGK-EYSFKMIKLD 52
+ ++ ++TGAS GIG + A + AG V G +R+ S+P + + +F + D
Sbjct: 5 QNKLAVVTGASGGIGAACARAMIGAGLRVVGLARREAKLKELRESLPRELQANFIPRRCD 64
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
++ E+ V+S+ + + + DVL+NNAGI + V +T K + +TN GV T
Sbjct: 65 VSKEDQVQSSFDWIERELEGADVLLNNAGITRETELVTPSNTQKLKEVIDTNVMGVIWCT 124
Query: 113 RAVLPHM-REQRHGKIINISSMGG------IMPIPYGALYCSSKHALEGYTESLDYEVKK 165
R +M R G ++ I+S+ G I +P +Y ++K A+ TE+ E
Sbjct: 125 REAFNNMKRRGGEGHVLIINSIAGHQVLNFIDVLPSFNIYPATKFAITAITETYRQE--- 181
Query: 166 FGIHVSTIDPHIIKTGMANSN 186
F +H + I I G N+N
Sbjct: 182 FQLHSNKIRVTGICPGAVNTN 202
>YIR036c [Q] KOG1204 Predicted dehydrogenase
Length = 263
Score = 70.1 bits (170), Expect = 3e-12
Identities = 55/192 (28%), Positives = 94/192 (48%), Gaps = 13/192 (6%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYE--VFGTSRKGS---IPGKEYS---FKMIKLDITD 55
+VILITGAS GIGL + +T+ E V+G +R + +EY F LDITD
Sbjct: 3 KVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQREYGADKFVYRVLDITD 62
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTD----LAKTIFETNFFGVHRM 111
+++ V E+ +K G++D +V NAG+ ++ + +++ + +F+ NFF + +
Sbjct: 63 RSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIVSL 122
Query: 112 TRAVLPHMREQRH-GKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV 170
LP ++ G I+ +SS + P + Y SK AL + + E +
Sbjct: 123 VALCLPLLKSSPFVGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKVRA 182
Query: 171 STIDPHIIKTGM 182
I P ++ T M
Sbjct: 183 VCIAPGVVDTQM 194
>CE20725 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 70.1 bits (170), Expect = 3e-12
Identities = 58/200 (29%), Positives = 91/200 (45%), Gaps = 22/200 (11%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIK 50
+V LITG+S GIG + A G +V T R K IP + + I
Sbjct: 7 KVALITGSSNGIGRAAAILFAQQGAKVTITGRNAERLKETRHEIKKSGIPAE--NILAIV 64
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFET----NFF 106
D+ +E +N+ + K G +D+LVNNAG A A D ++F+ N
Sbjct: 65 ADVITDEGQMRLINDTVRKFGHLDILVNNAGGAL-MDAQGRVGMDQDISVFDNTMQINMR 123
Query: 107 GVHRMTRAVLPHMREQRHGKIINISSM-GGIMPIPYGALYCSSKHALEGYTESLDYEVKK 165
V + + H+ + + G+IIN+S+M G P Y SK AL+ +T S + +
Sbjct: 124 SVVTLVQKAKEHLIKSK-GEIINVSAMAAGHHGDPIATFYGMSKAALDQFTRSSAISLIQ 182
Query: 166 FGIHVSTIDPHIIKTGMANS 185
G+ V+++ P KTG +
Sbjct: 183 HGVRVNSVSPGFTKTGFGEA 202
>7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 399
Score = 70.1 bits (170), Expect = 3e-12
Identities = 70/266 (26%), Positives = 113/266 (42%), Gaps = 36/266 (13%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEV--FGTSRKGSIPGKEYS------FKMIKLD 52
+ + LITG G+G +AE L G +V + ++KG + K +D
Sbjct: 84 LNTDIALITGGGNGLGRLLAERLGKMGTKVVIWDINKKGIAETVQIVEEAGGYCKGYVVD 143
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
I+ +E V A + + ++ G I +L+NNAG+ + + L + F N T
Sbjct: 144 ISKKEEVYKAADVIRDEVGDITLLINNAGVV-SGLHLLDTPDHLIERSFNVNVMAHFWTT 202
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFG---IH 169
+A LP M E G I I+S+ G + I YC+SK A G+ E+L E++ G I
Sbjct: 203 KAFLPKMIENDRGHIATIASLAGHVGISKLVDYCASKFAAVGFDEALRLELEVLGHTNIR 262
Query: 170 VSTIDPHIIK-TGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKV 228
+ I P I+ TGM +D + + + P +A V+
Sbjct: 263 TTCICPFFIQATGM-------------FDDVNARWVPTL---------NPNDVADRVIAA 300
Query: 229 IKTENPKSRYTPGKAKLYAYFSYYTP 254
I+ +N K PG K+ F + P
Sbjct: 301 IR-KNEKLAVIPGFLKVLLSFKWTFP 325
>7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 308
Score = 70.1 bits (170), Expect = 3e-12
Identities = 58/187 (31%), Positives = 87/187 (46%), Gaps = 19/187 (10%)
Query: 8 ITGASTGIGLSIAETLRSAGYEVF---GTSRKGSIPGKEYS-------FKMIKLDITDEE 57
+TGAS GIG A+ L V T K KE + K++ D T
Sbjct: 54 VTGASDGIGKEYAKELARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIADFTKG- 112
Query: 58 SVKSAVNEVIEKAGR---IDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
S V E IEK I +LVNN GIA + ++ + + + I +TN V +++R
Sbjct: 113 ---SQVYEHIEKETANIPISILVNNVGIATPKSLLKY-NQEETQNIIDTNVVAVSQLSRI 168
Query: 115 VLPHMREQR-HGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
M+ + G I+N+ S + P+P GA Y +SK T +L +E K +GIHV +
Sbjct: 169 FFQRMKASKLKGAIVNVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQML 228
Query: 174 DPHIIKT 180
P+ + T
Sbjct: 229 SPNFVVT 235
>Hs5031737 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 69.7 bits (169), Expect = 4e-12
Identities = 55/188 (29%), Positives = 87/188 (46%), Gaps = 9/188 (4%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK--------GSIPGKEYSFKMIKLD 52
+ +V ++TG+++GIG +IA L G V +SRK + G+ S I
Sbjct: 34 LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCH 93
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+ E + V + +E G +D LV +AG+ + S + I N +
Sbjct: 94 VGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLL 153
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
+LP+M E R G +I +SS+ P+ +Y SK AL G T +L E+ I V+
Sbjct: 154 SQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNC 212
Query: 173 IDPHIIKT 180
+ P IIKT
Sbjct: 213 VVPGIIKT 220
>At3g29250 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 69.7 bits (169), Expect = 4e-12
Identities = 57/216 (26%), Positives = 99/216 (45%), Gaps = 12/216 (5%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEV--------FGTSRKGSIPGKEYSFKMIKLDITD 55
++ +ITG ++GIG G +V G + SI + SF + ++TD
Sbjct: 9 KIAIITGGASGIGAEAVRLFTDHGAKVVIVDIQEELGQNLAVSIGLDKASF--YRCNVTD 66
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR-A 114
E V++AV +EK G++DVL +NAG+ + +V + + N G + A
Sbjct: 67 ETDVENAVKFTVEKHGKLDVLFSNAGVLEAFGSVLDLDLEAFDRTMAVNVRGAAAFIKHA 126
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
+ G I+ +S+ + P Y +SKHAL G S + ++GI V+ +
Sbjct: 127 ARSMVASGTRGSIVCTTSIAAEIGGPGPHSYTASKHALLGLIRSACAGLGQYGIRVNGVA 186
Query: 175 PHIIKTGMANS-NSPADEEMAVYDSIKGKVSERMLK 209
P+ + TGM ++ N A + + Y G + +LK
Sbjct: 187 PYGVATGMTSAYNEEAVKMLEEYGEALGNLKGVVLK 222
>At2g47120 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 69.7 bits (169), Expect = 4e-12
Identities = 54/219 (24%), Positives = 101/219 (45%), Gaps = 10/219 (4%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIP-------GKEYSFKMIKLDI 53
++ ++++ITG ++GIG A G +V + + GK+ + + D+
Sbjct: 6 LEGKIVIITGGASGIGADAARLFTDHGAKVVIVDVQEELGQNVAVLIGKDKA-SFYRCDV 64
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
T+E V+ AV +EK G++DVL +NAG+ + + + I N G +
Sbjct: 65 TNETEVEDAVKFTVEKHGKLDVLFSNAGVLEPLESFLDFDLERFDRIMAVNVRGAAAFIK 124
Query: 114 AVLPHMREQ-RHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
M E+ G I+ +S+ + + Y +SKH L G S ++ K+GI V+
Sbjct: 125 HAARAMVEKGTRGSIVCTTSVSAEIGGGHHG-YTASKHGLVGLIRSACGDLGKYGIRVNG 183
Query: 173 IDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQS 211
+ P+ + T M + + +++ Y KG + +LK S
Sbjct: 184 VAPYAVATPMTSHDEVTGKQLEDYFDAKGILKGMVLKAS 222
>SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 69.3 bits (168), Expect = 5e-12
Identities = 66/245 (26%), Positives = 112/245 (44%), Gaps = 23/245 (9%)
Query: 4 QVILITGASTGIGLSIAETLRSA-GYEVFGTSRK--GSIPGKEYS-----FKMIKLDITD 55
+V I G + GIGLS+ + L S G VF ++RK + +E+S K ++LD+T
Sbjct: 6 KVYFIAGGNRGIGLSLVKELSSREGTTVFASARKPEAATELQEWSKSHPNVKTVELDVTS 65
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
++S A V + IDVL N+GI + V E ++ ++TN G + +A
Sbjct: 66 QQSANEAAQSVAKAVDGIDVLWLNSGICQSYYTVMEAPEEVWNAHYQTNVLGPIHVFKAF 125
Query: 116 LPHMREQRHGKIINIS----SMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVS 171
P + +++ ++I S SMG + A Y SK A+ + L E+
Sbjct: 126 YPLLTKKKTRQVIFTSSECGSMGDFRATGFSA-YGQSKAAINFTMKELSVELADEHFTFI 184
Query: 172 TIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVIKT 231
+I P ++KT M N+ A ++ + S ML + + PE +LKV+
Sbjct: 185 SIHPGVVKTDM---NADAIKKFT-------ETSPEMLTYLKKVTIIPEESVSSMLKVVDN 234
Query: 232 ENPKS 236
P++
Sbjct: 235 LKPEN 239
>Hs20373187 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 231
Score = 69.3 bits (168), Expect = 5e-12
Identities = 56/191 (29%), Positives = 90/191 (46%), Gaps = 19/191 (9%)
Query: 4 QVILITGASTGIGLSIA-ETLRSAGYEVFGTSRKGSIPGKEYSFKMIK-----------L 51
+++LITGA +G+G +A + R V K G E + KM +
Sbjct: 41 EIVLITGAGSGLGRLLALQFARLGSVLVLWDINK---EGNEETCKMAREAGATRVHAYTC 97
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
D + +E V ++V ++ G + +L+NNAGI ++ C +L + F+ NF
Sbjct: 98 DCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLD-CPDELMEKSFDVNFKAHLWT 156
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV---KKFGI 168
+A LP M HG ++ ISS G+ + A YC+SK A G+ ES+ E K+ GI
Sbjct: 157 YKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGI 216
Query: 169 HVSTIDPHIIK 179
+ + P K
Sbjct: 217 KTTIVCPFFYK 227
>At3g26770 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 68.9 bits (167), Expect = 7e-12
Identities = 57/224 (25%), Positives = 101/224 (44%), Gaps = 16/224 (7%)
Query: 1 MKKQVILITGASTGIGLSIA-ETLRSAGYEVFGT--SRKGSIPGKEYSFK--MIKLDITD 55
++ +V LITG ++G+G + A E LR V + G+ KE + ++ D+T
Sbjct: 15 LEGKVALITGGASGLGKATASEFLRHGARVVIADLDAETGTKTAKELGSEAEFVRCDVTV 74
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIA--FKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
E + AV +E+ G++DV+ NNAGI A++ + + + N FGV +
Sbjct: 75 EADIAGAVEMTVERYGKLDVMYNNAGIVGPMTPASISQLDMTEFERVMRINVFGVVSGIK 134
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
M R G I+ SS+ G+ Y SK G +S E+ + G+ ++ I
Sbjct: 135 HAAKFMIPARSGCILCTSSVAGVTGGLAPHSYTISKFTTPGIVKSAASELCEHGVRINCI 194
Query: 174 DPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDE 217
P + T + ++ + KVSE L+++++ E
Sbjct: 195 SPGTVATPLT---------LSYLQKVFPKVSEEKLRETVKGMGE 229
>At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 305
Score = 68.9 bits (167), Expect = 7e-12
Identities = 59/223 (26%), Positives = 110/223 (48%), Gaps = 28/223 (12%)
Query: 7 LITGASTGIG-------------LSIAETLRSAGYEVFGTSRKGSIPGKE-YSFK---MI 49
L+TG ++GIG +++A+ G E R+ + + SF +
Sbjct: 10 LVTGGASGIGRALCLALAEKGVFVTVADFSEEKGQETTSLVREANAKFHQGLSFPSAIFV 69
Query: 50 KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFET---NFF 106
K D+T+ + +A ++ + G +D+ +NNAGI+ ++ TD +K+ T +
Sbjct: 70 KCDVTNRGDLLAAFDKHLATFGTLDICINNAGISTP-LRFDKDDTDGSKSWKHTINVDLI 128
Query: 107 GVHRMTRAVLPHMR-EQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKK 165
V T+ + M+ +Q+ G IIN+ S G+ P+P +Y +SK + +T SL Y ++
Sbjct: 129 AVVEGTQLAIKAMKAKQKPGVIINMGSAAGLYPMPVDPIYAASKAGVVLFTRSLAY-YRR 187
Query: 166 FGIHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERML 208
GI ++ + P IKT +A + + ++ +SI G +S ML
Sbjct: 188 QGIRINVLCPEFIKTDLAEA-----IDASILESIGGYMSMDML 225
>CE13008 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 247
Score = 68.6 bits (166), Expect = 9e-12
Identities = 56/179 (31%), Positives = 88/179 (48%), Gaps = 20/179 (11%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSRK-GSIPG-KEYSFKMIK---------LDIT 54
+++TG+S+GIG + A G +V T R G + K+ K++K ++T
Sbjct: 9 VIVTGSSSGIGRATAVLFAKYGAQVTITGRDAGKLEATKKKMLKVMKNPENVCVVVANLT 68
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGI-AFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
D + V ++ GRIDVLVNNAG + ST+L F+ NF V M +
Sbjct: 69 DSDGQDEIVQSALDAFGRIDVLVNNAGANVVDGTFNTDQSTELYHKTFQINFEAVIEMVK 128
Query: 114 AVLPHMREQRHGKIINISSMG----GIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
H+ E + G+I+N+SS+ + P PY Y +SK AL+ YT + ++ GI
Sbjct: 129 KTKNHLIESK-GEIVNVSSVAAGPQALAPSPY---YAASKAALDQYTRCVALDLILQGI 183
>At4g10020 [Q] KOG1205 Predicted dehydrogenase
Length = 389
Score = 68.6 bits (166), Expect = 9e-12
Identities = 50/182 (27%), Positives = 91/182 (49%), Gaps = 11/182 (6%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKG------SIPGKEYSFK---MIKL 51
M+ +V++ITGAS+ IG IA G + +R+ S K+ +I
Sbjct: 47 MEDKVVVITGASSAIGEQIAYEYAKRGANLVLVARREQRLRVVSNKAKQIGANHVIIIAA 106
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
D+ E+ + + + + GR+D LVN A + + E T + + + NF+G
Sbjct: 107 DVIKEDDCRRFITQAVNYYGRVDHLVNTASLGHTFYFEEVSDTTVFPHLLDINFWGNVYP 166
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVK-KFGIHV 170
T LP++ Q +G+I+ +S+ +P+P +LY ++K AL + E+L +E+ GI +
Sbjct: 167 TYVALPYL-HQTNGRIVVNASVENWLPLPRMSLYSAAKAALVNFYETLRFELNGDVGITI 225
Query: 171 ST 172
+T
Sbjct: 226 AT 227
>7294452 [Q] KOG1205 Predicted dehydrogenase
Length = 266
Score = 68.6 bits (166), Expect = 9e-12
Identities = 55/195 (28%), Positives = 86/195 (43%), Gaps = 18/195 (9%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRK---------GSIPGKEYSFKMIKLDIT 54
+V +++GAS GIG + L AG V G +R+ G ++ IK DIT
Sbjct: 21 KVAVVSGASAGIGAACTRALIGAGMIVVGLARRHERVEKLRSGLSLEQQSRLHAIKCDIT 80
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
E+ V A + + G +DVLV+NAGI E ++ ETN G R
Sbjct: 81 QEDQVLKAFDWTCRQLGGVDVLVSNAGIIGTGELSERDDGPAMRSTIETNIMGTVYCVRE 140
Query: 115 VLPHM-REQRHGKIINISSMGGIM------PIPYGALYCSSKHALEGYTE--SLDYEVKK 165
M R G ++ ++S+ G +P +Y ++K AL E +++ K
Sbjct: 141 SFRSMKRRGTEGHVVIVNSVAGYQVPNLGPQLPSLNIYPATKFALRAMNEIYRQEFQRHK 200
Query: 166 FGIHVSTIDPHIIKT 180
+ VST+ P I+ T
Sbjct: 201 TAVRVSTVSPGIVDT 215
>SPAC8E11.10 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 255
Score = 68.2 bits (165), Expect = 1e-11
Identities = 57/194 (29%), Positives = 93/194 (47%), Gaps = 13/194 (6%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEV---FGTSRKGSIPGKEY------SFKMIKL 51
+K + LITG S GIG SIA+ +AG V +G ++K E K
Sbjct: 7 LKGKTTLITGGSGGIGFSIAKAFAAAGSNVGLLYGRNKKALEYAAELRDKHGVQAKAYSC 66
Query: 52 DITDEESVKSAVNEVIEK-AGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHR 110
I + +V N+ +E+ GR+DV++ NAGIA ++E+ + D+ + N G +
Sbjct: 67 PIENRSAVIETTNQAVEELGGRLDVMIANAGIAIPHLSLEDKNEDIWTKVVGINLNGAYY 126
Query: 111 MTRAVLPHMREQRHGKIINISSMGG-IMPIP-YGALYCSSKHALEGYTESLDYEVKKFGI 168
+A H ++Q G +I +SM G I P A Y ++K A++ +L E F
Sbjct: 127 TAQAAGHHFKKQGKGSLIFTASMSGHIANWPQQWASYHATKAAVKHLARALAVEWAPFA- 185
Query: 169 HVSTIDPHIIKTGM 182
V+++ P I T +
Sbjct: 186 RVNSVSPGYIDTDL 199
>CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 258
Score = 68.2 bits (165), Expect = 1e-11
Identities = 59/198 (29%), Positives = 92/198 (45%), Gaps = 14/198 (7%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTS---RKGSIPGKEYSFKMIKLDITDEES 58
K V L+TG ++G+G AE L AG +V KG+ KE +T EE
Sbjct: 8 KGLVALVTGGASGLGKGAAEVLAKAGAQVAILDLPQSKGADVAKEIGGIFTPASVTSEEE 67
Query: 59 VKSAVNEVIEKAGRIDVLVNNAGI--AFKWAAVEE---CSTDLAKTIFETNFFGVHRMTR 113
V++A +V + GR+D LVN AGI AFK +V++ + + + N G + R
Sbjct: 68 VRAAFAKVQAEYGRLDALVNCAGIAYAFKLYSVQKKKHVDFEKIRQTIDVNVLGTFNVIR 127
Query: 114 AVLPHMREQ------RHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFG 167
+ M E + G +IN +S+ + Y +SK A+ G T L + G
Sbjct: 128 HGVALMGEHEKDANGQRGVVINTASVAAFDGQTGQSAYSASKGAIVGMTLPLARDFAGDG 187
Query: 168 IHVSTIDPHIIKTGMANS 185
I +TI P ++ T + +S
Sbjct: 188 IRFNTIAPGLMDTPLLSS 205
>7290988 [Q] KOG1205 Predicted dehydrogenase
Length = 249
Score = 68.2 bits (165), Expect = 1e-11
Identities = 61/206 (29%), Positives = 98/206 (46%), Gaps = 19/206 (9%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKG--------SIPGKE-YSFKMIKLD 52
+ +V +I+GAS+GIG + A L +AG +V G +R+ S+P ++ F K D
Sbjct: 5 QNRVAVISGASSGIGAACARLLVAAGLQVVGLARRTDRLEQLRQSLPAEQRMRFHQHKCD 64
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
++ E V +A + ++ G IDVL+NNAGI ++ + D+ I +TN G T
Sbjct: 65 VSQELQVDTAFEWIEKELGGIDVLINNAGIVLGGQLIDMPTKDI-NNILQTNLMGSIYCT 123
Query: 113 RAVLPHM-REQRHGKIINISSMGGI---MPIPYGA---LYCSSKHALEGYTESLDYEVKK 165
+ M R Q G +I ++S G+ P P Y SK AL E E+
Sbjct: 124 KLAASSMRRRQVAGHLIFVNSTAGVAGYKPDPADESLNAYTPSKFALTAVQEICRQELIN 183
Query: 166 FG--IHVSTIDPHIIKTGMANSNSPA 189
G I ++I+P + T + + A
Sbjct: 184 QGSKIKTTSINPGWVATEIVPDETKA 209
>Hs19923817 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 67.8 bits (164), Expect = 2e-11
Identities = 57/202 (28%), Positives = 92/202 (45%), Gaps = 21/202 (10%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK-------------GSIPGKEYSFK 47
++ QV ++TG +TGIG +I + L G V SRK P K+
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 48 MIKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFG 107
I+ +I +EE V + V ++ G+I+ LVNN G F + E S+ + ETN G
Sbjct: 76 PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQF-LSPAEHISSKGWHAVLETNLTG 134
Query: 108 VHRMTRAVLPHMREQRHGKIINI---SSMGGIMPIPYGALYCSSKHALEGYTESLDYEVK 164
M +AV ++ G I+NI + G + + GA ++ + T+SL E
Sbjct: 135 TFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGA----ARAGVYNLTKSLALEWA 190
Query: 165 KFGIHVSTIDPHIIKTGMANSN 186
GI ++ + P +I + A N
Sbjct: 191 CSGIRINCVAPGVIYSQTAVEN 212
>CE15574 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 67.8 bits (164), Expect = 2e-11
Identities = 59/197 (29%), Positives = 93/197 (46%), Gaps = 22/197 (11%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR-------------KGSIPGKEYSFKMIK 50
+V L+TG+S GIG + A L G +V T R + +P E I
Sbjct: 7 KVALVTGSSNGIGRATAILLAREGAKVTITGRNAQRLEETKQEILRSGVP--EDHVLSII 64
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFK----WAAVEECSTDLAKTIFETNFF 106
D+ E +N ++ GR+D+LVNNAG A V + KT+ N
Sbjct: 65 ADLATESGQIELMNSTVDIFGRLDILVNNAGAAITDLEGHIGVGTNVSVFDKTM-RINLR 123
Query: 107 GVHRMTRAVLPHMREQRHGKIINISSM-GGIMPIPYGALYCSSKHALEGYTESLDYEVKK 165
V +T+ H+ + + G+I+N+SS+ GG P Y SK AL+ YT S ++ +
Sbjct: 124 SVVTLTQKAKEHLIKTK-GEIVNVSSIAGGQHAQPELIYYAMSKSALDQYTRSAAIDLIQ 182
Query: 166 FGIHVSTIDPHIIKTGM 182
G+ V+++ P I+TG+
Sbjct: 183 HGVRVNSVSPGDIRTGI 199
>At5g51030 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 314
Score = 67.8 bits (164), Expect = 2e-11
Identities = 44/141 (31%), Positives = 73/141 (51%), Gaps = 13/141 (9%)
Query: 5 VILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKE---------YSFKMIKLDITD 55
V ++TGA+ GIG + L G V TSR ++ G E ++ +LDI D
Sbjct: 39 VAVVTGANRGIGFEMVRQLAGHGLTVILTSRDENV-GVEAAKILQEGGFNVDFHRLDILD 97
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
S++ + EK G IDVL+NNAG+ + + + S + + + TN++G + A+
Sbjct: 98 SSSIQEFCEWIKEKYGFIDVLINNAGVNYNVGS--DNSVEFSHMVISTNYYGTKNIINAM 155
Query: 116 LPHMREQRHG-KIINISSMGG 135
+P MR G +I+N++S G
Sbjct: 156 IPLMRHACQGARIVNVTSRLG 176
>At5g06060 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 67.8 bits (164), Expect = 2e-11
Identities = 57/210 (27%), Positives = 101/210 (47%), Gaps = 12/210 (5%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR-KGSIPGKEYSFKMIKLDITD---EESVKSA 62
L+TG + GIG ++ E L G +V SR + + +K L ++ + SV+
Sbjct: 15 LVTGGTRGIGRAVVEELAKFGAKVHTCSRNQEELNACLNDWKANGLVVSGSVCDASVRDQ 74
Query: 63 VNEVIEKA-----GRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLP 117
++I++A G++++L+NN G + VE S + AK I TN +++ P
Sbjct: 75 REKLIQEASSAFSGKLNILINNVGTNVRKPTVEYSSEEYAK-IMSTNLESAFHLSQIAHP 133
Query: 118 HMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHI 177
++ G I+ ISS+ G++ + G++Y ++K AL T +L E I + + P
Sbjct: 134 LLKASGVGSIVFISSVAGLVHLSSGSIYGATKGALNQLTRNLACEWASDNIRTNCVAPWY 193
Query: 178 IKTGMANSNSPADE--EMAVYDSIKGKVSE 205
IKT + + E E V + G+V E
Sbjct: 194 IKTSLVETLLEKKEFVEAVVSRTPLGRVGE 223
>At3g51680 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 67.8 bits (164), Expect = 2e-11
Identities = 55/196 (28%), Positives = 91/196 (46%), Gaps = 14/196 (7%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVF--------GTSRKGSIPGKEYS--FKMIK 50
++ +V +ITG + GIG + G V G+S S+ + S I
Sbjct: 32 LEGKVAIITGGAHGIGKATVMLFARHGATVVIADVDNVAGSSLAKSLSSHKTSPMVAFIS 91
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGI---AFKWAAVEECSTDLAKTIFETNFFG 107
D++ E V++ VN + + GR+D+L NNAG+ K ++ + D + N G
Sbjct: 92 CDVSVEADVENLVNVTVARYGRLDILFNNAGVLGDQKKHKSILDFDADEFDHVMRVNVRG 151
Query: 108 VH-RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKF 166
V M ++ G II+ +S+ G+M Y +SKHA+ G T++ E+ K+
Sbjct: 152 VGLGMKHGARAMIKRGFKGCIISTASVAGVMGGMGPHAYTASKHAIVGLTKNAACELGKY 211
Query: 167 GIHVSTIDPHIIKTGM 182
GI V+ I P + T M
Sbjct: 212 GIRVNCISPFGVATSM 227
>Hs7705925 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 244
Score = 67.4 bits (163), Expect = 2e-11
Identities = 50/185 (27%), Positives = 91/185 (49%), Gaps = 10/185 (5%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSRK----GSIPGKEYSFKMIKLDITDEESVKS 61
+L+TGA GIG + L + G V SR S+ + + + +D+ D E+ +
Sbjct: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATER 69
Query: 62 AVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPHMRE 121
A+ V G +D+LVNNA +A +E ++ FE N V ++++ V +
Sbjct: 70 ALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRS-FEVNLRAVIQVSQIVARGLIA 124
Query: 122 QR-HGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHIIKT 180
+ G I+N+SS + ++YCS+K AL+ T+ + E+ I V+ ++P ++ T
Sbjct: 125 RGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMT 184
Query: 181 GMANS 185
M +
Sbjct: 185 SMGQA 189
>CE09969 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 67.4 bits (163), Expect = 2e-11
Identities = 45/187 (24%), Positives = 88/187 (46%), Gaps = 12/187 (6%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKLDITDEESVKSAV 63
+V L+T ++ GIG +IA+ L +AG V SRK + + ++L+ D + V
Sbjct: 12 RVALVTASTKGIGFAIAKQLGAAGASVVVCSRKKE--NVDEAVAALRLENIDAHGTTAHV 69
Query: 64 NE----------VIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
+++ ++D+LV+NA + + + + + + + N +T+
Sbjct: 70 GNKSDRTKLIDFTLDRFTKLDILVSNAAVNPHYGDLMKVTDSQWDKLLDLNVKSAFELTK 129
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
+PH+ G ++ +SS+ G P+ Y K L G ++SL + + I V++I
Sbjct: 130 EAVPHLEASGRGNVVFVSSVAGYSPMNEIGAYSVMKTTLTGLSKSLALNLARRNIRVNSI 189
Query: 174 DPHIIKT 180
P II+T
Sbjct: 190 APGIIQT 196
>At3g26760 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 67.4 bits (163), Expect = 2e-11
Identities = 50/191 (26%), Positives = 93/191 (48%), Gaps = 15/191 (7%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTS---RKGSIPGKEY--SFKMIKLDITD 55
++ +V +ITG ++GIG + AE S G +V G + E + ++ D+T+
Sbjct: 5 LEGKVAVITGGASGIGKATAEEFVSQGAQVIIVDIDEEAGHMVATELGSAAHFLRCDVTE 64
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWA--AVEECSTDLAKTIFETN----FFGVH 109
EE + AV + + G++DV++N+AGI+ + ++ + D + N G+
Sbjct: 65 EEQIAKAVETAVTRHGKLDVMLNSAGISCSISPPSIADLDMDTYDKVMRLNVRGTVLGIK 124
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
RA++P G I+ +SS+ G+M Y SK + G +++ E+ K G+
Sbjct: 125 HAARAMIP----AGSGSILCLSSISGLMGGLGPHAYSISKFTIPGVVKTVASELCKHGLR 180
Query: 170 VSTIDPHIIKT 180
++ I P I T
Sbjct: 181 INCISPAGIPT 191
>At2g47130 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 67.4 bits (163), Expect = 2e-11
Identities = 53/215 (24%), Positives = 99/215 (45%), Gaps = 11/215 (5%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEV--------FGTSRKGSIPGKEYSFKMIKLDITD 55
++ +ITG ++GIG G +V G + S+ + SF + D+T+
Sbjct: 9 KIAIITGGASGIGAEAVRLFTDHGAKVVIVDFQEELGQNVAVSVGKDKASF--YRCDVTN 66
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E+ V++AV +EK G++DVL +NAG+ + + + + + N G +
Sbjct: 67 EKEVENAVKFTVEKYGKLDVLFSNAGVMEQPGSFLDLNLEQFDRTMAVNVRGAAAFIKHA 126
Query: 116 LPHMREQ-RHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
M E+ G I+ +S+ + P Y +SKHAL G +S + K+GI V+ +
Sbjct: 127 ARAMVEKGTRGSIVCTTSVASEIGGPGPHAYTASKHALLGLVKSACGGLGKYGIRVNGVA 186
Query: 175 PHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLK 209
P+ + T + + + + Y + G + +LK
Sbjct: 187 PYAVATAINSRDEETVRMVEEYSAATGILKGVVLK 221
>YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 308
Score = 67.0 bits (162), Expect = 3e-11
Identities = 65/271 (23%), Positives = 113/271 (40%), Gaps = 32/271 (11%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMI---KLDITDEES 58
K LITG S+G+G +A+ L +V + + + I + DIT +
Sbjct: 37 KNATALITGGSSGLGFELAKELSRRINKVIVADIQSFPTFAQVEYNNIFYYQCDITSLDE 96
Query: 59 VKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPH 118
+K+ + G I++++NNAG+A +E + + + + N G +R+
Sbjct: 97 IKNLKKAIERDHGNINIIINNAGVAHI-KKLEHMTNKEVEQLIDINLIGAYRIISTFAED 155
Query: 119 MREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTE-------SLDYEVKKFGIHVS 171
M + R G IINI+S+ G + Y +SK A+ G+ + SL E K GI
Sbjct: 156 MIDNREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLSTECNKTGIKTL 215
Query: 172 TIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVIKT 231
+ P IKT M + P ++ D I P +A ++ ++
Sbjct: 216 LVCPGKIKTNMF-IDVPTPSKLLAPDII------------------PSQLALAIISAMEH 256
Query: 232 ENPKSRYTPGKAKLYAYFSYYTPSWIFRRIL 262
+ ++ P L +F T SW +R +L
Sbjct: 257 NHLQTLNAPYYVNLVPFFK--TLSWPYRHLL 285
>At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 331
Score = 67.0 bits (162), Expect = 3e-11
Identities = 61/190 (32%), Positives = 94/190 (49%), Gaps = 23/190 (12%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIP---GKEYSFKMI 49
+K + + ITG S+GIGL++A S G +V +R K SI G E +
Sbjct: 35 IKFRHVFITGGSSGIGLALAHRAVSEGAKVSILARSTEKLAEAKRSIQLATGVEVA--TF 92
Query: 50 KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
D+ D ++V A++E +G IDVL+ N G+ F +E+ S + K + + N G
Sbjct: 93 SADVRDYDAVSKAIDE----SGPIDVLIVNQGV-FIGKELEKQSPEEVKFMIDVNLTGSF 147
Query: 110 RMTRAVLPHMREQRHGK----IINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKK 165
+ +A LP M+ R G+ I +SS G I Y +SK L+G ++L EV
Sbjct: 148 NVIKAALPAMKA-REGRGPASISLVSSQAGQAGIYGYTAYSASKFGLQGLAQALQQEVIS 206
Query: 166 FGIHVSTIDP 175
GIHV+ + P
Sbjct: 207 DGIHVTLLFP 216
>At3g61220 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 67.0 bits (162), Expect = 3e-11
Identities = 46/158 (29%), Positives = 71/158 (44%), Gaps = 29/158 (18%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR------------KGSIPGKEYSFKMIKLDIT 54
++TGA+ GIG I L S G V TSR K + + S +LD+
Sbjct: 10 VVTGANRGIGFEICRQLASEGIRVVLTSRDENRGLEAVETLKKELEISDQSLLFHQLDVA 69
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGI-----------------AFKWAAVEECSTDLA 97
D S+ S V + G++D+LVNNAGI FKW + + +L
Sbjct: 70 DPASITSLAEFVKTQFGKLDILVNNAGIGGIITDAEALRAGAGKEGFKWDEIITETYELT 129
Query: 98 KTIFETNFFGVHRMTRAVLPHMREQRHGKIINISSMGG 135
+ + N++G RM A +P ++ +I+N+SS G
Sbjct: 130 EECIKINYYGPKRMCEAFIPLLKLSDSPRIVNVSSSMG 167
>Hs4502601 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 277
Score = 66.2 bits (160), Expect = 4e-11
Identities = 48/140 (34%), Positives = 81/140 (57%), Gaps = 14/140 (10%)
Query: 4 QVILITGASTGIGLSIAETL-RSAGYEVFGTSRKGS--------IPGKEYSFKMIKLDIT 54
+V L+TGA+ GIGL+IA L R +V T+R + + + S + +LDI
Sbjct: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDL-AKTIFETNFFGVHRMTR 113
D +S+++ + + ++ G ++VLVNNA +AFK + + D+ A+ +TNFF M
Sbjct: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFK--SDDPMPFDIKAEMTLKTNFFATRNMCN 123
Query: 114 AVLPHMREQRHGKIINISSM 133
+LP M+ HG+++NISS+
Sbjct: 124 ELLPIMKP--HGRVVNISSL 141
>CE08181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 333
Score = 66.2 bits (160), Expect = 4e-11
Identities = 58/222 (26%), Positives = 105/222 (47%), Gaps = 32/222 (14%)
Query: 2 KKQVILITGASTGIGLSIAE--TLRSAGYEVFGTSRKGSIPGKEYSFKM---------IK 50
K V ++TG++ GIG LR A + S + + K + I+
Sbjct: 45 KGLVAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKRMLVRQGCDATRLHFIE 104
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHR 110
D+TD ESV+ A E +E ID+L+NNAGI F+ + E + D + +++N G
Sbjct: 105 CDLTDFESVRRAAKETLESTDTIDILINNAGIMFQ--SKHEQTKDGHEKTWQSNHLGPFL 162
Query: 111 MTRAVLPHMREQRHGKIINISSMGGIM-----------PIPYGAL--YCSSKHALEGYTE 157
+T LP +++ + +IIN+SS + +G + Y SK A +
Sbjct: 163 LTELFLPAVKKSSYARIINVSSRIHLKSEKINLATVDDKKSFGMMKSYRQSKLANVMHAR 222
Query: 158 SLDYEVKKFG---IHVSTIDPHIIKTGMANS---NSPADEEM 193
+L E++K G + V+++ P ++ T +A + N+P +++
Sbjct: 223 ALTKELRKDGAEHVTVNSLHPGVVNTELARNTILNTPGIKQI 264
>7300731 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 66.2 bits (160), Expect = 4e-11
Identities = 58/202 (28%), Positives = 94/202 (45%), Gaps = 19/202 (9%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIPGKEYS-FKMIKLDIT 54
+V ++TGAS GIG + L + G V G +R K S+P + + F D++
Sbjct: 7 RVAVVTGASAGIGAACCRDLVAKGMVVVGLARREKVLQDIKSSLPADQAARFHTRPCDVS 66
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
+E+ V + G DVLVNNAGI + + ++ + I + N GV TR
Sbjct: 67 NEQQVIDTFAWIDRTLGGADVLVNNAGIIRQMNITDPENSADVRAILDVNVLGVTWCTRQ 126
Query: 115 VLPHMREQR----HGKIINISSMGGIMPIPYG---ALYCSSKHALEGYTESLDYEVKKFG 167
++ ++ H +IN S +G +P G +Y SKHA+ TE L E K G
Sbjct: 127 WFLSLQRRKVNDGHVVVIN-SVVGHSVPAVEGFSLNMYAPSKHAITALTEILRQEFIKKG 185
Query: 168 IH--VSTIDPHIIKTGMANSNS 187
+++I P ++ T + + S
Sbjct: 186 TQTKITSISPGVVATEIFEAGS 207
>7292690 [Q] KOG1205 Predicted dehydrogenase
Length = 251
Score = 66.2 bits (160), Expect = 4e-11
Identities = 61/196 (31%), Positives = 91/196 (46%), Gaps = 20/196 (10%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIPGKEYS-FKMIKLDIT 54
+V ++TGAS+GIG + + L S G V G +R K S+P + S F K D++
Sbjct: 7 RVAVVTGASSGIGAACCKDLVSKGLVVVGLARREDRLQELKASLPADQASRFHGRKCDVS 66
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAV--EECSTDLAKTIFETNFFGVHRMT 112
E+ V A + G DVLVNNAGI + E DL + I +TN GV T
Sbjct: 67 QEQEVIDAFAWIDATLGGADVLVNNAGIVRLGVGITHEGNGADL-RAILDTNVLGVSWCT 125
Query: 113 RAVLPHM--REQRHGKIINISSMGGIMPIPYG----ALYCSSKHALEGYTESL--DYEVK 164
R + R G I+ ++S+ G I +Y SK+A+ TE L ++
Sbjct: 126 REAFKSLKRRNVNDGHILIVNSVAGHRVINNPGITMGMYSPSKYAVTALTEVLRQEFHNN 185
Query: 165 KFGIHVSTIDPHIIKT 180
K +++I P + T
Sbjct: 186 KTQTKITSISPGAVDT 201
>7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 320
Score = 66.2 bits (160), Expect = 4e-11
Identities = 62/246 (25%), Positives = 116/246 (46%), Gaps = 25/246 (10%)
Query: 4 QVILITGASTGIGLSIAETLRSAG-----YEVFGTSRKGSIP------GKEYSFKMIKLD 52
+V+LITG G+G +A G ++V + ++ GK + + +
Sbjct: 59 KVVLITGTGHGMGKEMALQYAKLGATILCWDVNEQTNNQTVKEIKNNGGKAFGYVC---N 115
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+T E + +V ++ G I V+VNNAGI +E ++ + ++E N +
Sbjct: 116 VTKREELIELAQKVRKEHGFIHVVVNNAGIMPCHPLLEHTENEI-RLMYEINVLSHFWII 174
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVK----KFGI 168
+A LP M E+ G I+ +SS G+ + YC +K A+ GY +L E++ + +
Sbjct: 175 QAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAALVEELRQKNPQNNV 234
Query: 169 HVSTIDPHIIKTGMANS---NSPADEEMAVYDSIKGKVSERMLKQSLENSDEPE--VIAK 223
++TI P++I TG+ + P ++ D G + E +Q LE + P V A+
Sbjct: 235 KLTTIYPYMIDTGLCKNPRYRFPNLFKLIPADVAAGSIIEAQ-RQGLEEAAIPRHFVAAE 293
Query: 224 EVLKVI 229
++ ++I
Sbjct: 294 KIGRLI 299
>CE11498 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 323
Score = 65.9 bits (159), Expect = 6e-11
Identities = 72/274 (26%), Positives = 121/274 (43%), Gaps = 43/274 (15%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKG--------SIPGKEYSFKMIK-- 50
++ QV L+TGAS GIG IA L AG V+ T R+ +P +Y K I
Sbjct: 5 LQDQVALVTGASRGIGRGIALQLGEAGATVYITGRRPELSDNFRLGLPSLDYVAKEITSR 64
Query: 51 --------LDITDEESVKSAVNEVIE-KAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIF 101
+D ++ VK ++ E + G++D+LVNN + ++ + + + KT F
Sbjct: 65 GGKGIALYVDHSNMTEVKFLFEKIKEDEEGKLDILVNNV-----YNSLGKATEMIGKTFF 119
Query: 102 --------ETNFFGV--HRMTRAVLPHMR-EQRHGKIINISSMGGIMPIPYGALYCSSKH 150
+ N G+ H M E+R G I+N+ S+GG+ + + Y + K
Sbjct: 120 DQDPSFWDDINGVGLRNHYYCSVYAARMMVERRKGLIVNVGSLGGLKYV-FNVAYGAGKE 178
Query: 151 ALEGYTESLDYEVKKFGIHVSTIDPHIIKTGMANSNSPAD------EEMAVYDSIKGKVS 204
AL + + E+ + + V T+ P +KT AN D E + + IKG+ +
Sbjct: 179 ALARMSTDMAVELNPYNVCVVTLIPGPVKTETANRTIIDDAYKMIKENPELEEFIKGEST 238
Query: 205 ERMLKQSLENSDEPEVIAKEVLKVIKTENPKSRY 238
E K + +P + K K + TE+ +Y
Sbjct: 239 EYTGKALARLAMDPGKLKKSG-KTLFTEDLAQKY 271
>SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 65.5 bits (158), Expect = 8e-11
Identities = 52/197 (26%), Positives = 89/197 (44%), Gaps = 16/197 (8%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMI------------KLDIT 54
L+TG +GIG + A G ++ + E + +I KLD +
Sbjct: 46 LLTGGDSGIGKAAAVMFAREGSDLVISCLPEERDDAEVTRDLIEREGRNCWIWEGKLDKS 105
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
D + + V+ ++K G IDVLVNN ++E+ + F+TN F +T+A
Sbjct: 106 D--NCRDLVDFALKKLGWIDVLVNNIAYQQVAQSIEDIDDEQWDLTFKTNIFSFFWVTKA 163
Query: 115 VLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
+ HM+ I+N SS+ + P Y S+K A+ +T L + + GI V+ +
Sbjct: 164 AISHMKS--GSSIVNCSSINAYVGRPDLLDYTSTKGAITAFTRGLSNQYAQHGIRVNAVA 221
Query: 175 PHIIKTGMANSNSPADE 191
P I T + +S P ++
Sbjct: 222 PGPIYTPLVSSTFPKEK 238
>CE02786 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 305
Score = 65.5 bits (158), Expect = 8e-11
Identities = 51/186 (27%), Positives = 87/186 (46%), Gaps = 7/186 (3%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKLDITDEESVKS- 61
K+ + I+G +G G +A L G + +K +F + L++ ++ESVK
Sbjct: 19 KKTVAISGCDSGFGRLLAVRLVKQGVPNGESLKKEVNTPSLLTFGI--LNVANDESVKEF 76
Query: 62 --AVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPHM 119
V + +E G V V NAGI + S + N FGV R + + +
Sbjct: 77 VKLVEKTVENRGLWGV-VANAGILGNSGPDDWLSAQDYINTMQVNTFGVMRFIQGLKKFV 135
Query: 120 REQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHIIK 179
++Q G+++ ISS+ G P P YC SKHA+E Y + + +E+ F + V ++P
Sbjct: 136 KKQE-GRVVIISSISGRTPRPTVGPYCVSKHAVEAYADVIRHELIDFNVSVHLLEPGFFT 194
Query: 180 TGMANS 185
T + +
Sbjct: 195 TNITQT 200
>7302393 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 355
Score = 65.5 bits (158), Expect = 8e-11
Identities = 63/232 (27%), Positives = 105/232 (45%), Gaps = 34/232 (14%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSF---------KMI--KLD 52
++ +ITG + GIGL I E L + V R I + K+I +LD
Sbjct: 68 RIAVITGGNRGIGLRIVEKLLACDMTVVMGVRDPKIAETAVASIVDLNATKGKLICEQLD 127
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+ D +SVK+ + E+ ++D+L+NNAGI F A + + D ++ F NF G +T
Sbjct: 128 VGDLKSVKAFAQLIKERYSKVDLLLNNAGIMF---APFKLTADGYESHFAINFLGHFLLT 184
Query: 113 RAVLPHMR----EQRHGKIINISS------------MGGIMPIPYGALYCSSKHALEGYT 156
+LP +R E R+ +I+N+SS + G G Y SK A +T
Sbjct: 185 HLLLPQLRAAGKEGRNSRIVNVSSCVNLIGRINYKDINGTKHYYPGTAYSQSKLAQILFT 244
Query: 157 ESLD--YEVKKFGIHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSER 206
L + +K + V+ + P I+ T + + A + ++ + K ER
Sbjct: 245 RHLQTLLDAEKSHVQVNVVHPGIVDTDLFEHS--ATTSVPIFKKLFFKTPER 294
>CE13054 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 240
Score = 65.1 bits (157), Expect = 1e-10
Identities = 41/138 (29%), Positives = 67/138 (47%), Gaps = 3/138 (2%)
Query: 47 KMIKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFF 106
K +D+++ + + + V + G++D+LVNNAGI + +C +L N
Sbjct: 24 KAYTVDLSEYKEINRTADLVKSEVGKVDILVNNAGIV-TGKKLLQCPDELMVKTVSVNTN 82
Query: 107 GVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV--K 164
+ T+ LP M E G I+ I+SM G + YC+SKH G+ +SL E+
Sbjct: 83 ALFFTTKNFLPGMLESNKGHIVTIASMAGKCGVAGLVDYCASKHGAVGFNDSLASELYAL 142
Query: 165 KFGIHVSTIDPHIIKTGM 182
K + + + P I TGM
Sbjct: 143 KKDVKTTVVCPIYINTGM 160
>At2g24190 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/158 (28%), Positives = 70/158 (43%), Gaps = 29/158 (18%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR------------KGSIPGKEYSFKMIKLDIT 54
++TG + GIG I L + G V TSR K + + S +LD++
Sbjct: 10 IVTGGNRGIGFEICRQLANKGIRVILTSRDEKQGLEAVETLKKELEISDQSIVFHQLDVS 69
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIA-----------------FKWAAVEECSTDLA 97
D SV S V G++D+L+NNAG+ FKW + +LA
Sbjct: 70 DPVSVTSLAEFVKTHFGKLDILINNAGVGGVITDVDALRAGTGKEGFKWEETITETYELA 129
Query: 98 KTIFETNFFGVHRMTRAVLPHMREQRHGKIINISSMGG 135
+ + N++G RM A +P ++ +IIN+SS G
Sbjct: 130 EECIKINYYGPKRMCEAFIPLLQLSDSPRIINVSSFMG 167
>Hs20070272 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 318
Score = 64.7 bits (156), Expect = 1e-10
Identities = 53/210 (25%), Positives = 92/210 (43%), Gaps = 33/210 (15%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR---KGSIPGKEYSFK-------MIKLDI 53
+V+++TGA+TGIG A+ L G V+ R KG + KE + KLD+
Sbjct: 42 KVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDL 101
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFE----TNFFGVH 109
+D +S+++ + + + VL+NNAG+ C FE N G
Sbjct: 102 SDTKSIRAFAKGFLAEEKHLHVLINNAGVMM-------CPYSKTADGFEMHIGVNHLGHF 154
Query: 110 RMTRAVLPHMREQRHGKIINISSMG------------GIMPIPYGALYCSSKHALEGYTE 157
+T +L ++E +I+N+SS+ G G YC SK A +T+
Sbjct: 155 LLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQ 214
Query: 158 SLDYEVKKFGIHVSTIDPHIIKTGMANSNS 187
L +K G+ ++ P +++ + +S
Sbjct: 215 ELARRLKGSGVTTYSVHPGTVQSELVRHSS 244
>CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 347
Score = 64.7 bits (156), Expect = 1e-10
Identities = 50/184 (27%), Positives = 83/184 (44%), Gaps = 16/184 (8%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRK--------------GSIPGKEYSFKMIKLD 52
++TG S GIG +A L G V +R G+ +D
Sbjct: 42 IVTGGSKGIGFQLAVGLIERGCHVTIVARNVKDLEKACADLQVLADQRGQRQKVHWKSID 101
Query: 53 ITDE-ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
+T + +KSA ++ + G ID+L+NNAG + + E TD K + N+
Sbjct: 102 MTGGYDVIKSAFDDAARELGPIDILINNAGHSVQAPFCELPITDFEKQM-AVNYLSAVHA 160
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVS 171
TRAV+ M+ ++ G I +SS G I + Y +K AL G+ ++L E+ + ++V
Sbjct: 161 TRAVVDDMKTRKTGHISFVSSAAGQFAIFGYSAYSPTKFALRGFADTLHMELLPYKVNVG 220
Query: 172 TIDP 175
+ P
Sbjct: 221 VLYP 224
>CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 315
Score = 64.7 bits (156), Expect = 1e-10
Identities = 50/197 (25%), Positives = 86/197 (43%), Gaps = 23/197 (11%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGS---------------IPGKEYSFKMIKL 51
++TGA+ GIG S + L G+ V+ SR S I + ++
Sbjct: 51 VVTGATDGIGKSYSFELARRGFNVYIVSRTQSKLEQTKKDILEKQPDIEVRFATYDFTNP 110
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEEC---STDLAKTIFETNFFGV 108
+TD E + S +NEV + +L+NN G+ F + + D + N
Sbjct: 111 SVTDYEKLLSKLNEV-----SVGILINNVGMFFDYPEMLHKINGGIDSIANVIIINTLPA 165
Query: 109 HRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
++ +LP M ++ G I+NI S G++ + ++Y ++K +E T L E GI
Sbjct: 166 TLLSAGILPQMVSRKAGIIVNIGSFAGVVKLAEWSIYSATKKYVEWLTGCLRKEYSHHGI 225
Query: 169 HVSTIDPHIIKTGMANS 185
I P ++ T MA +
Sbjct: 226 IFQAITPAMVATKMAGN 242
>At1g07440 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 266
Score = 64.7 bits (156), Expect = 1e-10
Identities = 58/236 (24%), Positives = 104/236 (43%), Gaps = 25/236 (10%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAG----------YEVFGTSRKGSIPGKEYSFKMIK 50
+K + +L+TG + GIG +I E G YE+ K G + + +
Sbjct: 12 LKAKTVLVTGGTKGIGHAIVEEFAGFGAVIHTCARNEYELNECLSKWQKKGFQVTGSVCD 71
Query: 51 LDITDE-ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
+ E E + V+ + G++D+L+NN G ++ + D + I TN +
Sbjct: 72 ASLRPEREKLMQTVSSMF--GGKLDILINNLGAIRSKPTLDYTAEDFSFHI-STNLESAY 128
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
+++ P ++ G II +SS+ G++ G++Y ++K AL +L E GI
Sbjct: 129 HLSQLAHPLLKASGCGNIIFMSSIAGVVSASVGSIYSATKGALNQLARNLACEWASDGIR 188
Query: 170 VSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEV 225
+ + P +I T +A AVYD KV + ++ L EPE ++ V
Sbjct: 189 ANAVAPAVIATPLAE---------AVYDDEFKKVV--ISRKPLGRFGEPEEVSSLV 233
>Hs4502599 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 277
Score = 64.3 bits (155), Expect = 2e-10
Identities = 51/162 (31%), Positives = 84/162 (51%), Gaps = 12/162 (7%)
Query: 5 VILITGASTGIGLSIAETL-RSAGYEVFGTSRKGS--------IPGKEYSFKMIKLDITD 55
V L+TG + GIGL+I L R +V T+R + + + S + +LDI D
Sbjct: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 66
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
+S+++ + + ++ G +DVLVNNAGIAFK A A+ +TNFFG + +
Sbjct: 67 LQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQ-AEVTMKTNFFGTRDVCTEL 125
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTE 157
LP ++ Q G+++N+SS+ + + + K E TE
Sbjct: 126 LPLIKPQ--GRVVNVSSIMSVRALKSCSPELQQKFRSETITE 165
>Hs18582884 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 64.3 bits (155), Expect = 2e-10
Identities = 51/206 (24%), Positives = 94/206 (44%), Gaps = 25/206 (12%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR---KGS-------IPGKEYSFKMIKLDI 53
+V++ITGA+TGIG A L S G V+ R KG + K + KLD+
Sbjct: 40 KVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
+D +S+++ + + ++ +L+NNAG+ + D +T N G +T
Sbjct: 100 SDTKSIRAFAEGFLAEEKQLHILINNAGVMM---CPYSKTADGFETHLGVNHLGHFLLTY 156
Query: 114 AVLPHMREQRHGKIINISSMG-GIMPIPY-----------GALYCSSKHALEGYTESLDY 161
+L ++ +++N+SS+ I IP+ G YC SK A +T L
Sbjct: 157 LLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAK 216
Query: 162 EVKKFGIHVSTIDPHIIKTGMANSNS 187
++ G+ + P ++++ + +S
Sbjct: 217 RLQGTGVTTYAVHPGVVRSELVRHSS 242
>CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 64.3 bits (155), Expect = 2e-10
Identities = 53/189 (28%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGK-------EYSFKMIKLDITDEESV 59
++TGA+ GIG S A L G+ +F SR S K +YS ++ I D V
Sbjct: 57 VVTGATDGIGRSYALDLARRGFNIFLISRTKSKLVKTKKQILNKYSDIEVRYAICDFTRV 116
Query: 60 K-SAVNEVIEKAGRIDV--LVNNAGIAFKWAAV---EECSTDLAKTIFETNFFGVHRMTR 113
++ +D+ L+NN G+ F V E D + N +T
Sbjct: 117 SYEDYKRLLHSLNEVDIGILINNVGMCFDNPEVLHRVEGGIDTLTNVINVNILP---LTA 173
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
+LP M ++ G I+NI S G + + ++Y ++K +E +T L E + GI TI
Sbjct: 174 GILPQMMARKSGIIVNIGSAAGSIHMAKWSVYSATKKYIEWFTSILQKEYENEGIICQTI 233
Query: 174 DPHIIKTGM 182
P ++ T M
Sbjct: 234 TPLLVSTNM 242
>CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 249
Score = 63.9 bits (154), Expect = 2e-10
Identities = 64/213 (30%), Positives = 99/213 (46%), Gaps = 28/213 (13%)
Query: 1 MKKQVILITGASTGIGLSIAET-LRSAGYEVF-GTSRKGSIPGKEYSFK-----MIKLDI 53
M + ILITGA+ GIGL + + +++ ++ GT R S + S K +++LDI
Sbjct: 1 MAPKSILITGANRGIGLGLLKQFIKNKDVQIIIGTCRDPSNATELNSIKDTRVHILQLDI 60
Query: 54 TDEESVKSAVNEVIEKAGR--IDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
++S++ EV + G + VL+NNAGI + E S ETN +
Sbjct: 61 DCDDSIRKLGAEVEKLVGEDGLTVLINNAGIFVPYDIDGEKSRSTLIRQLETNTISTVLI 120
Query: 112 TRAVLPHMREQ-----------RHGKIINISSMGGIMP-------IPYGALYCSSKHALE 153
T+ +LP ++ IINISS G + IP A Y SK AL
Sbjct: 121 TQELLPLLKRAAAKNRGEGYSINRSAIINISSTAGSITKIDASYNIPLVA-YRMSKSALN 179
Query: 154 GYTESLDYEVKKFGIHVSTIDPHIIKTGMANSN 186
+ +S ++ K+ I V+T P +KT M +N
Sbjct: 180 SFGKSCSVDLAKYHILVTTFCPGWVKTDMGGAN 212
>7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 255
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/199 (29%), Positives = 91/199 (45%), Gaps = 18/199 (9%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGT---SRKGSIPGKEYSFKMI--KLDITD 55
+K V L+TG ++G+G + AE L G V S KG+ KE K++ +D+T
Sbjct: 2 IKNAVSLVTGGASGLGRATAERLAKQGASVILADLPSSKGNEVAKELGDKVVFVPVDVTS 61
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIA-----FKWAAVEECSTDLAKTIFETNFFGVHR 110
E+ V +A+ +K GR+D+ VN AG A F + + + + N G
Sbjct: 62 EKDVSAALQTAKDKFGRLDLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVGTFN 121
Query: 111 MTR-------AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV 163
+ R A P+ QR G I+N +S+ A Y +SK A+ G T + ++
Sbjct: 122 VIRLSAGLMGANEPNQDGQR-GVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIARDL 180
Query: 164 KKFGIHVSTIDPHIIKTGM 182
GI + TI P + T M
Sbjct: 181 STQGIRICTIAPGLFNTPM 199
>CE02490_1 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 302
Score = 63.9 bits (154), Expect = 2e-10
Identities = 45/143 (31%), Positives = 70/143 (48%), Gaps = 16/143 (11%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGS----IPGKEYSF---------KMIK 50
+ +LITGAS GIG IA L G + ++ + +PG YS K +
Sbjct: 10 RTVLITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYSAAEEIEKAGGKALP 69
Query: 51 --LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
+D+ DE SVK++V E ++K G ID+L+NNA A E + N G
Sbjct: 70 CIVDVRDEASVKASVEEAVKKFGGIDILINNAS-AISLTDTENTEMKRYDLMHSINTRGT 128
Query: 109 HRMTRAVLPHMREQRHGKIINIS 131
MT+ LP+++ ++ ++NIS
Sbjct: 129 FLMTKTCLPYLKSGKNPHVLNIS 151
>At2g29320 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 63.5 bits (153), Expect = 3e-10
Identities = 48/191 (25%), Positives = 89/191 (46%), Gaps = 15/191 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSI--------PGKEYSFKMIKLDIT---D 55
L+TGA++GIG +I E L G ++ ++ K + D+T +
Sbjct: 19 LVTGAASGIGYAIVEELAGFGAKIHICDISKTLLNQSLSEWENKGFQVSGSVCDVTSHPE 78
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E + V+ + + G++++LVNN G+ E + D I TN + +
Sbjct: 79 REKLMQTVSSIFD--GKLNILVNNVGVLRGKPTTEYVADDFTFHI-STNLEAAYHFCQLS 135
Query: 116 LPHMREQRHGKIINISSMGGIMP-IPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
P ++ +G I+ +SS+ G++ I G++Y +K AL +L E K GI + +
Sbjct: 136 HPLLKASGYGSIVFLSSVAGVVSLIDCGSIYGLTKGALNQLARNLACEWAKDGIRANAVA 195
Query: 175 PHIIKTGMANS 185
P+++KT + S
Sbjct: 196 PNVVKTAQSQS 206
>YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 326
Score = 63.2 bits (152), Expect = 4e-10
Identities = 47/170 (27%), Positives = 79/170 (45%), Gaps = 4/170 (2%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKL--DITDEESV 59
K ++LITG S G+G +I L Y P + ++ L D++D+E V
Sbjct: 69 KNGIVLITGGSKGLGRAIVSQLLQ-DYSNLTILNVDICPSSVRNTRVKDLICDLSDDEEV 127
Query: 60 KSAVNEVIEK-AGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPH 118
+ +N + K I ++VNNAG+ + D IF+ N F + + + P
Sbjct: 128 AALLNLLKRKYKNEIRLIVNNAGVRANFTGFNGMERDNLDKIFKINTFAPLQFIQELAPS 187
Query: 119 MREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
R I+NI+S+ GI+ A Y +SK AL + +S +E++ G+
Sbjct: 188 RHSTRQCYIVNIASILGILTPAKVAAYAASKAALIAFHQSYSFELQNEGV 237
>SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 341
Score = 63.2 bits (152), Expect = 4e-10
Identities = 57/199 (28%), Positives = 83/199 (41%), Gaps = 17/199 (8%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR---KGSIPGKEYSFKMIKLDITDEESVKSAV 63
++TGA+ GIG A L +G+ V SR K KE T
Sbjct: 61 VVTGATDGIGKEYATQLAMSGFNVVLISRTQEKLDALAKELETVAKVKTRTIAIDYTKTT 120
Query: 64 NEVIEKAGR------IDVLVNNAGIA-FKWAAVEECSTDLAKTIFETNFFGVHRMTRAVL 116
E EK + I VL+NN G + + + E + I N FG T+AVL
Sbjct: 121 AETFEKLHQDLVGTPITVLINNVGQSHYMPTSFAETTVKEMDDIMHINCFGTLHTTKAVL 180
Query: 117 PHMREQRHGK-------IINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
M +R I+ + S G++P PY + Y SK L ++ SL EVKK GI
Sbjct: 181 SIMLRERQKNEKGPRCLILTMGSFAGLLPSPYLSTYAGSKAFLSNWSASLGEEVKKQGID 240
Query: 170 VSTIDPHIIKTGMANSNSP 188
V + +++ + M+ P
Sbjct: 241 VWCFNSYLVVSAMSKVRRP 259
>CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 251
Score = 62.8 bits (151), Expect = 5e-10
Identities = 56/191 (29%), Positives = 90/191 (46%), Gaps = 8/191 (4%)
Query: 14 GIGLSIAETLRSAGYEVFGTSRKG----SIPGKEYSFKMIKLDITDEESVKSAVN-EVIE 68
GIG I +L AG +V +R S+ + S + + I + S V ++I
Sbjct: 20 GIGKEICLSLAKAGAQVIAFARNEANLLSLVKETTSLRYTIIPIVGDVSANEEVLFKLIV 79
Query: 69 KAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPHMREQR-HGKI 127
I LVNNAGIA A + + +T F N G + + V + +++ G I
Sbjct: 80 PHFPIHGLVNNAGIATNHAIGQITQQSIDRT-FAVNVRGPILIAQLVARNFVDRQIKGSI 138
Query: 128 INISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHIIKTGMANSN- 186
+NISS I P+ +YC+SK AL+ T L E+ I V++++P ++ T M N
Sbjct: 139 VNISSQAAIRPLDNHTVYCASKAALDMVTRCLANELGSQNIRVNSVNPTVVMTDMGRDNW 198
Query: 187 SPADEEMAVYD 197
S D++ + D
Sbjct: 199 SDPDKKKKMLD 209
>At2g29310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 62.8 bits (151), Expect = 5e-10
Identities = 50/190 (26%), Positives = 89/190 (46%), Gaps = 14/190 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGY-----EVFGTSRKGSIPGKEYSFKMIKLDITD------ 55
L+TGA++GIG +I E L S G ++ T S+ E + I D
Sbjct: 13 LVTGAASGIGYAIVEELASFGAIIHICDISETLLSQSLSEWEKKGFQVSGSICDVASRPD 72
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E + V+ + + G++++LVNN G+ E + D + I TN ++
Sbjct: 73 REKLMQTVSSLFD--GKLNILVNNVGVIRGKPTTEYVAEDFSYHI-STNLEPAFHFSQLS 129
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
++ G I+ +SS G++ + G++Y +K AL T +L E K GI + + P
Sbjct: 130 HLLLKASGFGSIVFMSSATGVVSVQCGSIYSLTKGALNQLTRNLACEWAKDGIRANAVAP 189
Query: 176 HIIKTGMANS 185
+++KT ++ S
Sbjct: 190 NVVKTPLSQS 199
>7295622 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 62.8 bits (151), Expect = 5e-10
Identities = 59/196 (30%), Positives = 94/196 (47%), Gaps = 20/196 (10%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIPGK-EYSFKMIKLDIT 54
+V ++TGAS+GIG ++A L SAG V G +R K +P + + I D+
Sbjct: 7 RVAVVTGASSGIGAAVARHLVSAGVIVVGLARRVDRMKAIKEQLPPELQGRLHAIHCDVE 66
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
D +SV +A + + E+ G D+LVNNAG + + + + N GV TR
Sbjct: 67 DLDSVTAAFDWIEEQLGGCDILVNNAG-CLNPGQLLTLELEQLQQVLNVNLMGVVICTRR 125
Query: 115 VLPHMREQR-HGKIINISSMGGIMPI-PYG------ALYCSSKHALEGYTESLDYEVKKF 166
M+++ G +I I+S+ G I P G +Y +KH + E L E++ F
Sbjct: 126 AFRSMQQREVDGHVILINSLTGRNIINPPGDELQVLNMYPLTKHGVTAMLEVLRQELRGF 185
Query: 167 --GIHVSTIDPHIIKT 180
I V++I P + T
Sbjct: 186 KTKIKVTSITPGVTDT 201
>7294121 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 482
Score = 62.8 bits (151), Expect = 5e-10
Identities = 51/200 (25%), Positives = 94/200 (46%), Gaps = 24/200 (12%)
Query: 50 KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
K+DIT + + +A EK G DV+VN +G+ +++ +L + N GV
Sbjct: 276 KMDITQKSDIDAAYKATAEKLGHFDVVVNGSGL------LDDRRIELT---IQINLVGVI 326
Query: 110 RMTRAVLPHMREQRHGK---IINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV--K 164
T L +M + + G+ I+NISS+ G+ P P A+Y +SK + +T ++ +
Sbjct: 327 NSTLTALEYMDKSKGGRGGLIVNISSVAGLQPTPLMAIYSTSKTGVTTFTRAMASPIHYA 386
Query: 165 KFGIHVSTIDPHIIKTGM-----ANSNSPADEE--MAVYDSIKGKVSE---RMLKQSLEN 214
G+ TI P TG+ + P E V+ +KG+ +E R + ++E
Sbjct: 387 HSGVGFITICPGYTNTGILKDIDKKTTFPFYETRMRTVFSKVKGQTAEVCARNIVNAIET 446
Query: 215 SDEPEVIAKEVLKVIKTENP 234
+ V+ E+ ++ + + P
Sbjct: 447 AKNGAVLMLELGEIHELDIP 466
Score = 61.2 bits (147), Expect = 1e-09
Identities = 49/183 (26%), Positives = 81/183 (43%), Gaps = 16/183 (8%)
Query: 50 KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
KLDIT + + +A E+ G DV+VN +G+ + L + + N GV
Sbjct: 61 KLDITQKSDIDAAYKATAERFGHFDVVVNGSGL---------MNDRLVELTIQINLLGVI 111
Query: 110 RMTRAVLPHMREQRHGK---IINISSMGGIMPIPYGALYCSSKHALEGYTESL--DYEVK 164
T L +M + + GK I+NISS+ G+ P A+Y ++K + +T ++ Y
Sbjct: 112 NSTLTALEYMDKAKGGKGGLIVNISSVAGLQPTAIMAIYSAAKTGVTTFTRAMANPYFYA 171
Query: 165 KFGIHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKE 224
G+ TI P TG+ ++ YD+ + R+ +Q E+ V A E
Sbjct: 172 HSGVGFLTICPGFTDTGLL--EDIGNKTTFTYDTPMLAMFNRVKRQKAEDCARNLVSAIE 229
Query: 225 VLK 227
K
Sbjct: 230 TSK 232
>Hs20558355 [Q] KOG1205 Predicted dehydrogenase
Length = 165
Score = 62.4 bits (150), Expect = 6e-10
Identities = 37/157 (23%), Positives = 78/157 (49%), Gaps = 10/157 (6%)
Query: 102 ETNFFGVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDY 161
+ N+FG +T+A+LP+M +R G+I+ ++++ G IP+ Y +SKHA G+ + L
Sbjct: 2 DANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRA 61
Query: 162 EVKKFGIHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVI 221
EV+++ + +ST+ P I++ + E +++ + + L P +
Sbjct: 62 EVEEYDVVISTVSPTFIRSYHVYPEQ-GNWEASIW---------KFFFRKLTYGVHPVEV 111
Query: 222 AKEVLKVIKTENPKSRYTPGKAKLYAYFSYYTPSWIF 258
A+EV++ ++ + + K Y + P + F
Sbjct: 112 AEEVMRTVRRKKQEVFMANPIPKAAVYVRTFFPEFFF 148
>At3g05260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 289
Score = 62.4 bits (150), Expect = 6e-10
Identities = 53/187 (28%), Positives = 82/187 (43%), Gaps = 18/187 (9%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKG--------------SIPGKEYSFK-M 48
+V L+TG +GIG ++ G V T KG + +E M
Sbjct: 40 KVALVTGGDSGIGKAVCHCYALEGASVAFTYVKGREDKDAEETLRLLHEVKTREAKEPIM 99
Query: 49 IKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
I D+ EE+ K V EV+ GRIDVLVN A + ++E+ + +F TN F
Sbjct: 100 IATDLGFEENCKRVVEEVVNSFGRIDVLVNCAAEQHE-VSIEDIDEARLERVFRTNIFSQ 158
Query: 109 HRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
+ + L HM+E IIN +S+ Y ++K A+ +T L ++ GI
Sbjct: 159 FFLVKYALKHMKE--GSSIINTTSVVAYAGNSSLLEYTATKGAIVSFTRGLALQLAPKGI 216
Query: 169 HVSTIDP 175
V+ + P
Sbjct: 217 RVNGVAP 223
>At2g29300 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 263
Score = 62.4 bits (150), Expect = 6e-10
Identities = 49/189 (25%), Positives = 91/189 (47%), Gaps = 15/189 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPG---KEYSFKMIKL-----DIT---D 55
L+TGA++GIG +I E L G + ++ +E+ K ++ D+T +
Sbjct: 13 LVTGAASGIGYAIVEELAGFGARIHVCDISETLLNQSLREWEKKGFQVSGSVCDVTSRPE 72
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E + V+ + + G++++LVNN G+ E + D I TN + +
Sbjct: 73 REKLMQTVSSLFD--GKLNILVNNVGVLRAKPTTEYVADDFTFHI-STNLEAAYHFCQLS 129
Query: 116 LPHMREQRHGKIINISSMGGIMPIP-YGALYCSSKHALEGYTESLDYEVKKFGIHVSTID 174
P ++ +G I+ +SS+ G++ I G+LY +K AL +L E K GI + +
Sbjct: 130 HPLLKTSGYGSIVFLSSVSGVVSITDCGSLYGLTKGALNQLARNLACEWAKDGIRANAVA 189
Query: 175 PHIIKTGMA 183
P+++KT +
Sbjct: 190 PNVVKTAQS 198
>At1g01800 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 309
Score = 62.0 bits (149), Expect = 8e-10
Identities = 40/147 (27%), Positives = 74/147 (50%), Gaps = 15/147 (10%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR------------KGSIPGKEYSFKMIKL 51
+V ++TG++ GIG I L + G V T+R K + + L
Sbjct: 35 RVAVVTGSNKGIGFEICRQLANNGITVVLTARDENKGLAAVQKLKTENGFSDQAISFHPL 94
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFE---TNFFGV 108
D+++ +++ S V + G++D+LVNNAG+ V+ +A+ + E TN++GV
Sbjct: 95 DVSNPDTIASLAAFVKTRFGKLDILVNNAGVGGANVNVDVLKAQIAEIVEECVKTNYYGV 154
Query: 109 HRMTRAVLPHMREQRHGKIINISSMGG 135
RM A++P ++ +I++I+S G
Sbjct: 155 KRMCEAMIPLLQSSDSPRIVSIASTMG 181
>7301617_1 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 302
Score = 62.0 bits (149), Expect = 8e-10
Identities = 49/189 (25%), Positives = 81/189 (41%), Gaps = 18/189 (9%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGS----IPGKEYSFKM----------- 48
+ + ITGAS GIG IA G + ++ +PG YS
Sbjct: 10 RTLFITGASRGIGKEIALKAARDGANIVVAAKTAEPHPKLPGTIYSAAEEIEKAGGKAYP 69
Query: 49 IKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
+D+ DE+ V+SAV + K G ID+++NNA A + + N G
Sbjct: 70 CVVDVRDEQQVRSAVEAAVAKFGGIDIVINNAS-AISLTNTPDTDMKRYDLMHNINTRGT 128
Query: 109 HRMTRAVLPHMREQRHGKIINISSMGGIMPIPYG--ALYCSSKHALEGYTESLDYEVKKF 166
+++ LP++++ H I+NIS + P +G Y +K+ + + E K
Sbjct: 129 FLVSKVCLPYLKKSNHAHILNISPPLSMKPKWFGPHVAYTMAKYGMSMCVLGMAAEFKDE 188
Query: 167 GIHVSTIDP 175
GI V+ + P
Sbjct: 189 GISVNALWP 197
>Hs4759084 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 302
Score = 61.6 bits (148), Expect = 1e-09
Identities = 53/192 (27%), Positives = 85/192 (43%), Gaps = 11/192 (5%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYE---VFGTSRKGSIPGKEYSFKM------IKL 51
+ ++ +LITG GIG +A G ++G + K E +M
Sbjct: 36 LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFIC 95
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
D+ + E V V EK G I +LVNNA + + ++ L K+ N G
Sbjct: 96 DVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQ-HINTLGQFWT 154
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKF-GIHV 170
T+A LP M E ++G I+ ++S+ + IP YC+SK + + ESL + G+
Sbjct: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSA 214
Query: 171 STIDPHIIKTGM 182
+T+ P T M
Sbjct: 215 TTVLPFHTSTEM 226
>Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 310
Score = 61.6 bits (148), Expect = 1e-09
Identities = 53/190 (27%), Positives = 89/190 (45%), Gaps = 14/190 (7%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSR---KGSIPGKEY------SFKMIKLDIT 54
Q +ITGA GIG + + L G V SR K E S K+I+ D T
Sbjct: 49 QWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFT 108
Query: 55 DEESVKSAVNEVIEKAG-RIDVLVNNAGIAFKWAAVEECST-DLAKTIFETNFFGVHRMT 112
++ + ++ AG I +LVNN G+ + D +++ N V +MT
Sbjct: 109 KDDIYEHIKEKL---AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMT 165
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
+ +L HM ++ G I+NISS + P P ++Y +SK + ++++L E K + +
Sbjct: 166 QLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV 225
Query: 173 IDPHIIKTGM 182
+ P+ + T M
Sbjct: 226 LTPYAVSTAM 235
>CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 349
Score = 61.6 bits (148), Expect = 1e-09
Identities = 49/195 (25%), Positives = 88/195 (45%), Gaps = 23/195 (11%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGS---------------IPGKEYSFKMIKL 51
+ITG + GIG S + L G+ ++ SR S + + +F
Sbjct: 51 VITGGTDGIGKSFSFELAKRGFNIYIVSRTQSKLEQTKKEIMEKYSNVEVRFATFDFTNP 110
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECST---DLAKTIFETNFFGV 108
I+D + + S +NEV I +L+NN G+ F++ + D+ + N V
Sbjct: 111 SISDYKKLLSQLNEV-----SIGMLINNVGMLFEYPENLHKTVGGIDVVANVTILNTLPV 165
Query: 109 HRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
++ +LP M ++ G I+NI S+ G + ++Y +SK +E T L E + GI
Sbjct: 166 TLLSAGILPQMVSRKTGIIVNIGSVAGAAKMAEWSVYSASKKYVEWLTGCLRKEYEHQGI 225
Query: 169 HVSTIDPHIIKTGMA 183
+ I P ++ T ++
Sbjct: 226 IIQAITPALVATKLS 240
>CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 61.6 bits (148), Expect = 1e-09
Identities = 51/197 (25%), Positives = 86/197 (42%), Gaps = 23/197 (11%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGS---------------IPGKEYSFKMIKL 51
++TGA+ GIG S + L G+ V+ SR S I + +F
Sbjct: 51 VVTGATDGIGKSYSFELAKRGFNVYIVSRTQSKLEHTKKEILEVHPDIEVRFATFDFTNP 110
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEEC---STDLAKTIFETNFFGV 108
++D E + S +NEV I +L+NN G+ F + + D + N
Sbjct: 111 SVSDYEKLLSKLNEV-----SIGILINNVGMFFDYPEMLHKINGGIDSIANVTIINTLPA 165
Query: 109 HRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
++ +LP M ++ G I+NI S+ G+ + ++Y ++K +E T L E GI
Sbjct: 166 TLLSAGILPQMVPRKAGIIVNIGSVAGLATMAEWSVYSATKKYVEWITGCLQKEYGHQGI 225
Query: 169 HVSTIDPHIIKTGMANS 185
I P ++ T MA +
Sbjct: 226 IFQAITPAMVATKMAGN 242
>7300387 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 61.6 bits (148), Expect = 1e-09
Identities = 48/204 (23%), Positives = 96/204 (46%), Gaps = 24/204 (11%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIPGKEYSFKMI--K 50
M+ + ++ITGA++GIG A+ L G + R K I + + K++ K
Sbjct: 31 MEGKTVIITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKETKNNKILVKK 90
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHR 110
LD+ ++SV+ ++++ +IDVL++NAG+A + + S D + TN +G
Sbjct: 91 LDLGSQKSVREFAADIVKTEPKIDVLIHNAGMALAFRG--QTSEDGVELTMATNHYGPFL 148
Query: 111 MTRAVLPHMREQRHGKI------------INISSMGGIMPIPYGALYCSSKHALEGYTES 158
+T ++ +++ +I +N++ + I P LY SK A +
Sbjct: 149 LTHLLIDVLKKSAPARIVIVASELYRLSSVNLAKLNPIGTFPAAYLYYVSKFANIYFARE 208
Query: 159 LDYEVKKFGIHVSTIDPHIIKTGM 182
L ++ + V+ + P +I +G+
Sbjct: 209 LAKRLEGTKVTVNFLHPGMIDSGI 232
>SPCC736.13 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 339
Score = 61.2 bits (147), Expect = 1e-09
Identities = 57/210 (27%), Positives = 95/210 (45%), Gaps = 37/210 (17%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGK----------EYSFKMIKLDI 53
+V L+TG+S GIG A L G +V+ R K + ++LD+
Sbjct: 43 KVALVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQIHDEVRHSKIRFLRLDL 102
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
D ESV A I K ++ +LVNNAGI E + D + +TN+ + T
Sbjct: 103 LDFESVYQAAESFIAKEEKLHILVNNAGI---MNPPFELTKDGYELQIQTNYLSHYLFTE 159
Query: 114 AVLPHMR----EQRHG--KIINISSMGGIMPIPYGALYC-----------------SSKH 150
+LP +R E R G +I++++S+ + PY +Y SK+
Sbjct: 160 LLLPTLRRTAEECRPGDVRIVHVASI-AYLQAPYSGIYFPDLNLPHVLLGTFARYGQSKY 218
Query: 151 ALEGYTESLDYEVKKFGIHVSTIDPHIIKT 180
A Y+ +L ++K+GI+ ++ P +I+T
Sbjct: 219 AQILYSIALAKRLEKYGIYSVSLHPGVIRT 248
>CE05801 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 374
Score = 61.2 bits (147), Expect = 1e-09
Identities = 45/171 (26%), Positives = 82/171 (47%), Gaps = 9/171 (5%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFG---TSRKGSIPGKEYS---FKMIKLDIT 54
++ + ILITG TG G +A+ G+ VF T+ E + + + LD++
Sbjct: 26 LQDRAILITGCDTGFGRELAKKCAKNGFLVFAGCLTTEAAKTLESESANPRLRTVPLDVS 85
Query: 55 DEESVKSAVNEVIEKAG--RIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+ESV+ V V + G ++ +VNNAGI + + C + K + N GV R+T
Sbjct: 86 KDESVEKTVEFVKKSLGNHKLWGVVNNAGIFSCYGPDDWCRMNDYKLALDVNCLGVIRVT 145
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV 163
+A ++ + G+I+ ++S+ G + P Y SK Y + + + +
Sbjct: 146 QAFKKLVKAAK-GRIVTVTSVNGRLSTPAAGPYVVSKFGAAAYMDCIRFVI 195
>CE05427 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 293
Score = 61.2 bits (147), Expect = 1e-09
Identities = 47/188 (25%), Positives = 85/188 (45%), Gaps = 30/188 (15%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGS----IPGKEYSFKM----------- 48
+ + ITGAS GIG IA L G + ++ + +PG Y+
Sbjct: 14 KTVFITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYTAAAEIEKAGGHALP 73
Query: 49 IKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
+D+ DE +VK+AV+ ++K G ID+L+NNA A E+ + N G
Sbjct: 74 CVVDVRDEAAVKAAVDAAVKKFGGIDILINNAS-AISLTNTEDTDMKRYDLMHSINTRGT 132
Query: 109 HRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
+ +T+ LP++++ ++ ++NIS P+ A + + + Y + KFG+
Sbjct: 133 YLLTKTCLPYLKKGKNPHVLNISP-----PLDMEAKW---------FGPHVGYTMAKFGM 178
Query: 169 HVSTIDPH 176
+ + H
Sbjct: 179 SMCVLGHH 186
>7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 278
Score = 61.2 bits (147), Expect = 1e-09
Identities = 52/193 (26%), Positives = 92/193 (46%), Gaps = 29/193 (15%)
Query: 7 LITGASTGIGLSIAETLRSAG------------YEVFGTSRKGSIPGKEYSFKMIKLDIT 54
++TG + GIGL +++ L +AG E F R S +IK+D+
Sbjct: 26 VVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAH---PTQSVMIIKMDVA 82
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
+++ V++ E+ + G ID++VN AGI D+ +T+ N G+ T +
Sbjct: 83 NKKGVEATYEEIAKTFGNIDIVVNVAGIF--------NDKDVQRTLL-VNLGGIINSTLS 133
Query: 115 VLPHMREQRHGK---IINISSMGGIMPIPYGALYCSSKHALEGYTESLDYE--VKKFGIH 169
LP+M + GK ++N+SS+ G+ P+ +Y ++K + +T L E ++ GI
Sbjct: 134 ALPYMGKDNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGIK 193
Query: 170 VSTIDPHIIKTGM 182
T+ P T M
Sbjct: 194 FVTVCPGATMTDM 206
>Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 261
Score = 60.8 bits (146), Expect = 2e-09
Identities = 56/203 (27%), Positives = 88/203 (42%), Gaps = 20/203 (9%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMI-------KLDI 53
+K V +ITG ++G+GL+ AE L G S G E K + D+
Sbjct: 8 VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNS--GGEAQAKKLGNNCVFAPADV 65
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIA-----FKWAAVEECSTDLAKTIFETNFFGV 108
T E+ V++A+ K GR+DV VN AGIA + + + + + + + N G
Sbjct: 66 TSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGT 125
Query: 109 HRMTRAVLPHMREQ------RHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYE 162
+ R V M + + G IIN +S+ A Y +SK + G T + +
Sbjct: 126 FNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARD 185
Query: 163 VKKFGIHVSTIDPHIIKTGMANS 185
+ GI V TI P + T + S
Sbjct: 186 LAPIGIRVMTIAPGLFGTPLLTS 208
>CE09505 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 249
Score = 60.8 bits (146), Expect = 2e-09
Identities = 58/220 (26%), Positives = 96/220 (43%), Gaps = 26/220 (11%)
Query: 1 MKKQVILITGASTGIGLSIAET-LRSAGYEVFGTSRKGSIPGKEYS------FKMIKLDI 53
M + +LITGA+ GIGL + + L+ ++ + + +E S ++ LDI
Sbjct: 1 MSPKSLLITGANRGIGLGLLKQFLKHKDIQIIIATCRDPSKAEELSNLKDSRLHILPLDI 60
Query: 54 TDEESVKSAVNEVIEKAGR--IDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
+ES+ EV + G + VL+NNAGI + E + ETN +
Sbjct: 61 DCDESISKLYAEVEKLVGEDGLTVLLNNAGILLPYDVEGEKNRKTLIRQLETNSVSTALI 120
Query: 112 TRAVLPHMREQ-----------RHGKIINISSMGGIMPIPYGAL------YCSSKHALEG 154
T+ LP +++ I+NISS + G Y SK AL
Sbjct: 121 TQEFLPLLKKAAAKNGGDGYSINRAAIVNISSTAASVEKIDGTFNGPLVAYRMSKSALNS 180
Query: 155 YTESLDYEVKKFGIHVSTIDPHIIKTGMANSNSPADEEMA 194
+ +S ++ K+ I V++ P +KTGM +N+ + E A
Sbjct: 181 FAKSCSIDLAKYHILVTSFCPGWVKTGMGGANAMLEIEDA 220
>SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 236
Score = 60.5 bits (145), Expect = 2e-09
Identities = 57/200 (28%), Positives = 90/200 (44%), Gaps = 12/200 (6%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSRKG-SIPGKEYSFKMIK-----LDITDEESV 59
+LITG S+G+G IA+ G++ R + S + K L I D +S
Sbjct: 4 VLITGGSSGLGKRIAQIWSQKGHQCHIVGRNEFHLKETLQSLSVAKGQQHTLTIADVQSD 63
Query: 60 KSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR-AVLPH 118
+ + E ID +V+ AG+ V ++ +I TN ++++ A+L
Sbjct: 64 MKNLKSIFESV-EIDTVVHAAGVLQSSLCVRTSEKEI-DSIICTNLVSAIKLSKMAILEW 121
Query: 119 MRE---QRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
R +R I+NISS +P ++Y +SK LE +T+ L EV GI V+ I P
Sbjct: 122 FRNKNSERDRLILNISSRLSTYALPGTSVYAASKAGLESFTKVLAAEVASKGIRVNAISP 181
Query: 176 HIIKTGMANSNSPADEEMAV 195
+ T M +S A E V
Sbjct: 182 GYVDTPMLSSQIRAIAEKKV 201
>Hs10047132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 245
Score = 60.5 bits (145), Expect = 2e-09
Identities = 52/183 (28%), Positives = 88/183 (47%), Gaps = 13/183 (7%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIK---LDITDEESVK 60
+VI++T A+ GIG + A G +V T S + + I+ LD+T ++ +
Sbjct: 7 KVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQID 66
Query: 61 SAVNEVIEKAGRIDVLVNNAGIAFKWAAV--EECSTDLAKTIFETNFFGVHRMTRAVLPH 118
NEV R+DVL N AG + EE D + + N ++ M +A LP
Sbjct: 67 QFANEV----ERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNL---NVRSMYLMIKAFLPK 119
Query: 119 MREQRHGKIINISSM-GGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHI 177
M Q+ G IIN+SS+ + + +Y ++K A+ G T+S+ + + GI + + P
Sbjct: 120 MLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGT 179
Query: 178 IKT 180
+ T
Sbjct: 180 VDT 182
>At5g50770 [Q] KOG1205 Predicted dehydrogenase
Length = 342
Score = 60.5 bits (145), Expect = 2e-09
Identities = 62/240 (25%), Positives = 115/240 (47%), Gaps = 26/240 (10%)
Query: 4 QVILITGASTGIGLSIAETL--RSA--------GYEVFGTSRKGSIPGKEYSFKMIKLDI 53
+V++ITGA++GIG ++A R A G +F + + G ++ D+
Sbjct: 48 KVVVITGAASGIGEALAYEYGKRGAYLALVDIRGEPLFHVAALAELYGSPEVLPLVA-DV 106
Query: 54 TDEESVKSAVNEVIEKAGRIDVLVNNAGIA--FKWAAVEECSTDLAKTIFETNFFGVHRM 111
+ + + + + GR+D LV NAG+A + +A +E+ S A + NF+G
Sbjct: 107 SKLQDCERFIRATVLHFGRLDHLVTNAGVAPLYFFADIEDVSK--ASPAMDINFWGSVYC 164
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFG--IH 169
T P++++ R G+I+ I+S G + P + YC+SK A+ + E+L E FG I
Sbjct: 165 TFFASPYLKKFR-GRIVVIASGCGYIASPRLSFYCASKAAVIAFYETLRTE---FGSDIG 220
Query: 170 VSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVI 229
V+ + P I+ + M+ + V D R ++ S+ + E AK +++ +
Sbjct: 221 VTIVAPGIVDSEMSRGKFMTKDGKLVVDK-----ELRDVQMSVLPVESAERCAKAIMRSV 275
>At3g59710 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 302
Score = 60.1 bits (144), Expect = 3e-09
Identities = 44/142 (30%), Positives = 72/142 (49%), Gaps = 14/142 (9%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIK----------LDITDE 56
++TGA+ GIG ++ + L G V T+R G + + + + LDI+D
Sbjct: 32 VVTGANKGIGFAVVKRLLELGLTVVLTARNAE-NGSQAAESLRRIGFGNVHFCCLDISDP 90
Query: 57 ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVL 116
S+ + + G +D+LVNNA ++F AV E +TI +TNF+G +T A+L
Sbjct: 91 SSIAAFASWFGRNLGILDILVNNAAVSFN--AVGENLIKEPETIIKTNFYGAKLLTEALL 148
Query: 117 PHMREQ-RHGKIINISSMGGIM 137
P R +I+N+SS G +
Sbjct: 149 PLFRRSVSVSRILNMSSRLGTL 170
>At4g03140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 283
Score = 59.7 bits (143), Expect = 4e-09
Identities = 55/206 (26%), Positives = 90/206 (42%), Gaps = 13/206 (6%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKM------IKLDIT 54
++ +V LITG ++GIG + A S G +V + I G+E ++ D+T
Sbjct: 18 LEGKVALITGGASGIGKATAGKFISHGAKVIIADIQPQI-GRETEQELGPSCAYFPCDVT 76
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKW-AAVEECSTDLAKTIFETNFFGVHRMTR 113
E + +AV+ + ++D++ NNAGI K ++ + ++ + TN GV +
Sbjct: 77 KESDIANAVDFAVSLHTKLDIMYNNAGIPCKTPPSIVDLDLNVFDKVINTNVRGVMAGIK 136
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
M + G II S+ G+M Y SK A+ G S E+ K I V+ I
Sbjct: 137 HAARVMIPRNSGSIICAGSVTGMMGGLAQHTYSVSKSAVIGIVRSTASELCKHRIRVNCI 196
Query: 174 DPHIIKTGMANSNSPADEEMAVYDSI 199
P I T DE +Y +
Sbjct: 197 SPFAITTSFV-----MDEMRQIYPGV 217
>At2g47140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 59.3 bits (142), Expect = 5e-09
Identities = 49/188 (26%), Positives = 87/188 (46%), Gaps = 15/188 (7%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEV--------FGTSRKGSIPGKEYSFKMIKLDITD 55
++++ITG ++GIG G V G + SI + S+ D+T+
Sbjct: 16 KIVIITGGASGIGAESVRLFTEHGARVVIVDVQDELGQNVAVSIGEDKASY--YHCDVTN 73
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E V++AV +EK G++DVL +NAG+ + ++ + + + N G +
Sbjct: 74 ETEVENAVKFTVEKYGKLDVLFSNAGVIEPFVSILDLNLNELDRTIAINLRGTAAFIKHA 133
Query: 116 LPHMREQR-HGKIINISSMGGIM--PIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
M E+ G I+ +S+ + P+G Y +SKH L G +S + K+GI V+
Sbjct: 134 ARAMVEKGIRGSIVCTTSVAAEIAGTAPHG--YTTSKHGLLGLIKSASGGLGKYGIRVNG 191
Query: 173 IDPHIIKT 180
+ P + T
Sbjct: 192 VAPFGVAT 199
>At2g29340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 59.3 bits (142), Expect = 5e-09
Identities = 47/194 (24%), Positives = 90/194 (46%), Gaps = 10/194 (5%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFG---TSRKGSIPGKEYSFKMIKL-----D 52
+K L+TG ++GIG +I E L G + + K + E+ K ++ D
Sbjct: 7 LKGMTALVTGGASGIGYAIVEELAGFGARIHVCDISEAKLNQSLSEWEKKGFQVSGSVCD 66
Query: 53 ITDEESVKSAVNEVIEK-AGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
+ + + V + G++++LV+N G+ E D A I +N +
Sbjct: 67 VASRPEREELMQTVSSQFDGKLNILVSNVGVIRSKPTTEYTEDDFAFHI-SSNVEAAYHF 125
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVS 171
++ P ++ +G II +SS+ G++ G++Y +K AL ++L E K GI +
Sbjct: 126 SQLSHPLLKASGYGSIIFVSSIAGVISFDAGSIYGLTKGALIQLAKNLACEWAKDGIRAN 185
Query: 172 TIDPHIIKTGMANS 185
+ P++I T ++ S
Sbjct: 186 AVAPNVINTPLSQS 199
>CE28758 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 253
Score = 58.9 bits (141), Expect = 7e-09
Identities = 60/250 (24%), Positives = 109/250 (43%), Gaps = 27/250 (10%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGK--EYSFKM------IKLDITDEES 58
L+ GA++ +G ++ L GY+V + + GK E + K+ LD+ + E
Sbjct: 5 LVIGATSTLGKAVVRRLAFTGYKVAAAADCPNSVGKVAEDNIKVGGDVTAFSLDVANAEH 64
Query: 59 VKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPH 118
K + +V EK G +D L+ + E S + +F N R+++A +
Sbjct: 65 RKELITKVAEKLGGLDTLIIVPPQNEVLGEIIETSGEDFDKLFANNLTTPFRLSQAAMST 124
Query: 119 MREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHII 178
+ + ++G II ++S G P LY + ++ T+S+ K G+ V+++ +I
Sbjct: 125 LAKSQNGSIIYLTSCFGFTPSIDMGLYSVASSSVLSLTKSVAQSAAKQGVRVNSVVSGMI 184
Query: 179 KTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENS------DEPEVIAKEVLKVIKTE 232
+ D AV+D G+ R +KQ LE+ P +A V + T
Sbjct: 185 E---------GDGTGAVWDHASGE-EARQIKQHLESMIPLGRLGRPSDVASYVEFLAST- 233
Query: 233 NPKSRYTPGK 242
K+RY G+
Sbjct: 234 --KARYITGE 241
>At2g29360 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 271
Score = 58.9 bits (141), Expect = 7e-09
Identities = 45/196 (22%), Positives = 89/196 (44%), Gaps = 14/196 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR----------KGSIPGKEYSFKMIKLDITDE 56
L+TG S GIG ++ E L + G + +R K G + + + + D+
Sbjct: 22 LVTGGSKGIGEAVVEELATLGARIHTCARDETQLQESLRKWQAKGFQVTTSVCDVSSRDK 81
Query: 57 -ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E + V+ + E G++++LVNN G ++ + D + T+ TN +++
Sbjct: 82 REKLMETVSTIFE--GKLNILVNNVGTCIVKPTLQHTAEDFSFTM-ATNLESAFHLSQLA 138
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
P ++ G I+ ISS+ G++ + ++Y SK A+ +L E I +++ P
Sbjct: 139 HPLLKASGSGSIVLISSVSGVVHVNGASIYGVSKGAMNQLGRNLACEWASDNIRTNSVCP 198
Query: 176 HIIKTGMANSNSPADE 191
I+T + + +E
Sbjct: 199 WFIETPLVTESLSNEE 214
>At2g29170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 58.9 bits (141), Expect = 7e-09
Identities = 46/198 (23%), Positives = 91/198 (45%), Gaps = 14/198 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTS----------RKGSIPGKEYSFKMIKLDITDE 56
L+TG S G+G ++ E L G V + R+ G E + + + D+
Sbjct: 22 LVTGGSKGLGEAVVEELAMLGARVHTCARNETQLQECVREWQAKGFEVTTSVCDVSSRDQ 81
Query: 57 -ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E + V + + G++++LVNNAG E + D + + TN +++
Sbjct: 82 REKLMENVASIFQ--GKLNILVNNAGTGITKPTTEYTAQDYS-FLMATNLDSAFHLSQLA 138
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
P ++ G I+ +SS G++ I G++Y ++K A+ ++L E + I V+++ P
Sbjct: 139 HPLLKASGSGSIVLMSSTAGVVHINVGSIYGATKGAMNQLAKNLACEWARDNIRVNSVCP 198
Query: 176 HIIKTGMANSNSPADEEM 193
I T + ++ +E+
Sbjct: 199 WFIATPLYLNDEELKKEV 216
>CE21514 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 319
Score = 58.5 bits (140), Expect = 9e-09
Identities = 59/212 (27%), Positives = 96/212 (44%), Gaps = 38/212 (17%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKG--------SIPGKEYSFKMIK----- 50
Q+ ++TGAS GIG IA L AG V+ T RK + G E + I
Sbjct: 6 QIAIVTGASRGIGRGIALQLGEAGATVYITGRKPEESLNSKVGLSGLEATADEITKRGGK 65
Query: 51 -----LDITDEESVKSAVNEVIEK--AGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFET 103
+D + E VK+ EV+EK G++D+LVNNA + V S ++ K +ET
Sbjct: 66 GIARFVDHQNMEEVKNFF-EVVEKEHQGQLDILVNNA-----YQGVTAISENMGKPFYET 119
Query: 104 NFFGVHRMTRAVLPH-----------MREQRHGKIINISSMGGIMPIPYGALYCSSKHAL 152
+ + + L + M + G I+N+SS GG+ + + Y K AL
Sbjct: 120 DPYVWDTINNVGLRNHYFCTVYAARLMTARNKGLIVNVSSGGGLRYL-FNVAYGVGKQAL 178
Query: 153 EGYTESLDYEVKKFGIHVSTIDPHIIKTGMAN 184
+ + E++K + V +I P ++T + +
Sbjct: 179 DRMSADTAVELRKKNVCVVSIWPGAVRTELVD 210
>CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 296
Score = 58.5 bits (140), Expect = 9e-09
Identities = 57/235 (24%), Positives = 112/235 (47%), Gaps = 19/235 (8%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK--------GSIPGKEYSFKMIKLD 52
+ ++ ++TG +GIG +I + ++G + K G++PG +S ++D
Sbjct: 54 LSSKLAIVTGGGSGIGQAICKKFAASGARLIVADLKKSAAEATAGNLPGNGHS--AFEID 111
Query: 53 ITDEESVKSAVNEVIEKAGRI-DVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
++D E V + + E I+ +G VLVN AGI K A + + S + + + N V M
Sbjct: 112 VSDPEHV-ARLQEFIKSSGESPSVLVNCAGIT-KDATLLKMSQNQWQDVMNVNLNSVFLM 169
Query: 112 TRAVLPH-MREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV 170
++ + + I+N+SS+ G + Y ++K + G+T+S E+ I V
Sbjct: 170 SQMIARESVAAGSPLSIVNVSSIVGKIGNFGQTNYAATKSGVIGFTKSAARELATKNIRV 229
Query: 171 STIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEV 225
+ + P I+T M + P V D++ V +R L ++ E ++ +A ++
Sbjct: 230 NAVLPGFIRTPMTEAMPP-----KVLDAMVSMVPQRRLGETEEIANAVLFLASDM 279
>CE04339 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 255
Score = 58.5 bits (140), Expect = 9e-09
Identities = 49/190 (25%), Positives = 93/190 (48%), Gaps = 13/190 (6%)
Query: 9 TGASTGIGLSIAETLRSAGYEVF--------GTSRKGSIPGKEYSFKMIKLDITDEESVK 60
+G ++GIG +I++TL G V + ++P + S D+++ +SVK
Sbjct: 20 SGGASGIGKAISQTLAKHGARVVVADLDSGNAAATAKALPASQ-SHSSFACDVSNADSVK 78
Query: 61 SAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPHMR 120
++E ++ G +LVN AGI K + + + + ++ + N GV +++A +
Sbjct: 79 G-LSEHVKSLGTPSILVNCAGIT-KDSTLLKMKQEQWDSVIKVNLTGVFHVSQAFVKASV 136
Query: 121 EQRHG--KIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHII 178
+ + IIN+SS+ G M Y ++K + G+T+S E+ K + V+ + P I
Sbjct: 137 DNNNHPLSIINVSSIVGKMGNFGQTNYAATKAGVIGFTKSAAKELAKKNVRVNAVLPGFI 196
Query: 179 KTGMANSNSP 188
KT M + P
Sbjct: 197 KTPMTEAMPP 206
>At2g29350 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 58.5 bits (140), Expect = 9e-09
Identities = 55/211 (26%), Positives = 95/211 (44%), Gaps = 15/211 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPG---KEYSFK--MIKLDITDEESVKS 61
L+TG S GIG ++ E L G +V +R + +E+ K + + D S
Sbjct: 21 LVTGGSKGIGEAVVEELAMLGAKVHTCARDETQLQERLREWQAKGFQVTTSVCDVSSRDQ 80
Query: 62 AVN--EVIEKA--GRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLP 117
V E + G++++LVNN G + E + D + + TN +++ P
Sbjct: 81 RVKLMETVSSLYQGKLNILVNNVGTSIFKPTTEYTAEDFS-FVMATNLESAFHLSQLAHP 139
Query: 118 HMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHI 177
++ G I+ ISS G++ + G++Y ++K A+ +L E I +++ P
Sbjct: 140 LLKASGSGSIVLISSAAGVVHVNVGSIYGATKGAMNQLARNLACEWASDNIRTNSVCPWY 199
Query: 178 IKTGMANSNSPADEEM---AVYDSIKGKVSE 205
I T + SN DEE AV + G+V E
Sbjct: 200 ITTPL--SNDFFDEEFKKEAVRTTPMGRVGE 228
>At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 308
Score = 58.5 bits (140), Expect = 9e-09
Identities = 51/191 (26%), Positives = 90/191 (46%), Gaps = 21/191 (10%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKL--------- 51
++ V++ITGAS GIG +IA L AG +V + + +E + ++ +
Sbjct: 74 VESPVVVITGASRGIGKAIALALGKAGCKVLVNYARSAKEAEEVAKQIEEYGGQAITFGG 133
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
D++ V + + ++K G IDV+VNNAGI + + + I N GV
Sbjct: 134 DVSKATDVDAMMKTALDKWGTIDVVVNNAGITRDTLLIRMKQSQWDEVI-ALNLTGVFLC 192
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVS 171
T+ G+IINISS+ G++ A Y ++K + ++++ E I+V+
Sbjct: 193 TQ-----------GRIINISSVVGLIGNIGQANYAAAKGGVISFSKTAAREGASRNINVN 241
Query: 172 TIDPHIIKTGM 182
+ P I + M
Sbjct: 242 VVCPGFIASDM 252
>YBR159w [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 347
Score = 58.2 bits (139), Expect = 1e-08
Identities = 58/199 (29%), Positives = 88/199 (44%), Gaps = 27/199 (13%)
Query: 8 ITGASTGIGLSIAETLRSAGYEVFGTSRKGS---IPGKEYS------FKMIKLDIT-DEE 57
ITGAS GIG A + G+ + SR S KE K++ +DI D+E
Sbjct: 67 ITGASDGIGKEFARQMAKRGFNLVLISRTQSKLEALQKELEDQHHVVVKILAIDIAEDKE 126
Query: 58 SVKSAVNEVIEKAGRIDVLVNNAG----IAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
S ++ E+ + I VLVNN G I + EE + I N +T+
Sbjct: 127 SNYESIKELCAQLP-ITVLVNNVGQSHSIPVPFLETEEKEL---RNIITINNTATLLITQ 182
Query: 114 AVLPHMREQ---------RHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVK 164
+ P + E G I+ + S GG++P P A Y SK L+G++ SL E+
Sbjct: 183 IIAPKIVETVKAENKKSGTRGLILTMGSFGGLIPTPLLATYSGSKSFLQGWSNSLAGELS 242
Query: 165 KFGIHVSTIDPHIIKTGMA 183
K I V I +++ + M+
Sbjct: 243 KDAIDVELIISYLVTSSMS 261
>SPCC1739.08c [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/192 (26%), Positives = 95/192 (48%), Gaps = 12/192 (6%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGT------SRKGSIPGKEYSFKM--IKLD 52
+K + ++ GA+ GIG SIA AG V T + K +E ++ +K+D
Sbjct: 19 LKGKNCVVFGAAKGIGFSIATAFAQAGGNVIITYLTTDPTEKAKKLAEETGVQVHTLKID 78
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
I+ ++V++ V E+ + I V+V NAG+ F+ + ++ + K + N V+R+
Sbjct: 79 ISRSDTVEAGVEEIQKIFKEIHVVVANAGMPFRRSVLDSPPHEFEK-VMNINTNSVYRVA 137
Query: 113 RAVLPHMREQRHGKIINISSMGG-IMPIP-YGALYCSSKHALEGYTESLDYEVKKFGIHV 170
+ ++Q G +I +SM I+ P + A YC+SK A+ ++L E +F +
Sbjct: 138 YYMGKIFKKQGFGNLIATASMSATIVNAPQHIAAYCASKAAVRQLCKALAVEWAEFA-RI 196
Query: 171 STIDPHIIKTGM 182
+++ P T M
Sbjct: 197 NSVSPGYFATDM 208
>CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 333
Score = 57.8 bits (138), Expect = 2e-08
Identities = 48/190 (25%), Positives = 86/190 (45%), Gaps = 13/190 (6%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSIPGKEYSFKMIKLDITDEES 58
++TGA+ GIG + A L G+ V SR K I K S ++ +
Sbjct: 68 VVTGATDGIGKAYAFELARRGFNVLLVSRTQSKLDETKKEILEKYSSIEVRTAAFDFTNA 127
Query: 59 VKSAVNEVIEKAGRID--VLVNNAGIAFKWAAV---EECSTDLAKTIFETNFFGVHRMTR 113
SA +++ +++ VL+NN G+++++ V + + I N ++
Sbjct: 128 APSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIERLANITTINTLPPTLLSA 187
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
+LP M ++ G I+N+ S G + A+Y ++K + T L E + GI V TI
Sbjct: 188 GILPQMVARKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRKEYEHQGITVQTI 247
Query: 174 DPHIIKTGMA 183
P ++ T M+
Sbjct: 248 APMMVATKMS 257
>Hs13236542 [Q] KOG1205 Predicted dehydrogenase
Length = 181
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 23/167 (13%)
Query: 73 IDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPHMREQR--HGKIINI 130
+D+ +NNAG+A + + ST K +F N + TR M+E+ G IINI
Sbjct: 12 VDICINNAGLA-RPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIINI 70
Query: 131 SSMGG--IMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV--STIDPHIIKTGMANSN 186
+SM G ++P+ Y ++K+A+ TE L E+++ H+ + I P +++T A
Sbjct: 71 NSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKL 130
Query: 187 SPADEE--MAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVIKT 231
D E A Y+ +K LK PE +A+ V+ V+ T
Sbjct: 131 HDKDPEKAAATYEQMK------CLK--------PEDVAEAVIYVLST 163
>CE25799 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 265
Score = 57.4 bits (137), Expect = 2e-08
Identities = 56/214 (26%), Positives = 94/214 (43%), Gaps = 30/214 (14%)
Query: 6 ILITGASTGIGLSIAET-LRSAGYEVFGTSRKGSIPGKEYS-------FKMIKLDITDEE 57
I+ITGA+ GIG + + L G E+ + + E + +I L++ D+E
Sbjct: 20 IMITGANRGIGFGLVKHFLEYDGIELLIATCRNPEKADELNALKNDRRLHVIALNVDDDE 79
Query: 58 SVKSAVNEV--IEKAGRIDVLVNNAGIAFKWA--AVEECSTDLAKTIFETNFFGVHRMTR 113
S+K +EV + + +++L+NNAGI + + C + K + ETN V +T+
Sbjct: 80 SIKKVFDEVSSLVSSNGLNMLINNAGILLPYEVDGPKICRKTMMKQL-ETNSVSVAILTQ 138
Query: 114 AVLPHMREQR-----------HGKIINISSMGGIMPIPYGAL------YCSSKHALEGYT 156
LP ++ IINISS + + G Y SK AL +
Sbjct: 139 IFLPLIKTAASAAEGDEASIDRASIINISSTMASIEMNNGCFDGPMTAYRMSKSALNAFA 198
Query: 157 ESLDYEVKKFGIHVSTIDPHIIKTGMANSNSPAD 190
E+ K+ I V++ P ++T M N+ D
Sbjct: 199 RQSFMELSKYHILVTSFCPGWVRTDMGGDNADLD 232
>Hs4503301 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 335
Score = 56.6 bits (135), Expect = 4e-08
Identities = 49/187 (26%), Positives = 90/187 (47%), Gaps = 11/187 (5%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSI---PGKEYSFK------MIKLDIT 54
+V ITG TG+G + L S G + SRK + ++ S + I+ D+
Sbjct: 60 KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
Query: 55 DEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
D + V++ V+E+I+ AG ++++NNA F + E S + KTI + G +T
Sbjct: 120 DPDMVQNTVSELIKVAGHPNIVINNAAGNF-ISPTERLSPNAWKTITDIVLNGTAFVTLE 178
Query: 115 VLPHM-REQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTI 173
+ + + Q+ ++I+++ + S+K +E ++SL E K+G+ + I
Sbjct: 179 IGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVI 238
Query: 174 DPHIIKT 180
P IKT
Sbjct: 239 QPGPIKT 245
>CE10908 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 313
Score = 56.6 bits (135), Expect = 4e-08
Identities = 57/211 (27%), Positives = 92/211 (43%), Gaps = 12/211 (5%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYS---------FKMIKLDIT 54
+V L+TG TG+G +IA T G V +R+ + K + ++D+
Sbjct: 27 KVALVTGGGTGLGKAIATTFAHLGASVAIAARRLDVLEKTADEIRSSTGGVCEPFQMDVK 86
Query: 55 DEESVKSAVNEVIEKAGRI-DVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFG-VHRMT 112
D V A + V +K G D+L+NNA F A E S + TI + G +H T
Sbjct: 87 DPAKVAKAFDAVEKKLGHTPDILINNAAGNF-IMATERLSPNAYGTIIDIVLKGTLHVTT 145
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
++++R +++I+++ P+ SK +E T+SL E K G+ +
Sbjct: 146 ELGRRCIQQKRGASVLSITTLYAQSGAPFVVPSAVSKAGVENMTKSLASEWAKHGLRFNA 205
Query: 173 IDPHIIKTGMANSNSPADEEMAVYDSIKGKV 203
I P I T A A E D++K V
Sbjct: 206 IAPGPIPTEGAFGRLFAGELKDSGDAMKASV 236
>At5g04900 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 341
Score = 56.6 bits (135), Expect = 4e-08
Identities = 55/197 (27%), Positives = 88/197 (43%), Gaps = 15/197 (7%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSRKGS-IPGKEYSFKM--------IKLDITDE 56
ILITG++ GIG ++A AG V SR + S K K D+T+
Sbjct: 82 ILITGSTKGIGYALAREFLKAGDNVVICSRSAERVETAVQSLKEEFGEHVWGTKCDVTEG 141
Query: 57 ESVKSAVNEVIEKAGRIDVLVNNAGI-AFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
+ V+ V + ID+ +NNAG A+ + + E S + + +TN G+ R
Sbjct: 142 KDVRELVAYSQKNLKYIDIWINNAGSNAYSFKPLAEASDEDLIEVVKTNTLGLMLCCREA 201
Query: 116 LPHMREQ-RHGKIINISSMGGI-MPIPYGALYCSSKHALEGYTESLDYEVKKFGIH---V 170
+ M Q R G I NI G P P A Y ++K ++ T+SL E++ + V
Sbjct: 202 MNMMLTQSRGGHIFNIDGAGSDGRPTPRFAAYGATKRSVVHLTKSLQAELQMQDVKNVVV 261
Query: 171 STIDPHIIKTGMANSNS 187
+ P ++ T + S +
Sbjct: 262 HNLSPGMVTTDLLMSGA 278
>At3g04000 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 272
Score = 56.6 bits (135), Expect = 4e-08
Identities = 60/233 (25%), Positives = 99/233 (41%), Gaps = 39/233 (16%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVF-------------------GTSRKGSIPGKEY 44
+V ++TG+S GIG +IA L G V S+ + GK
Sbjct: 17 RVAIVTGSSRGIGRAIAIHLAELGARVVVNYSTSPVEAEKVATAITTNCSKDAEVAGKSP 76
Query: 45 SFKMIKLDITDEESVKSAVNE---VIEKAGRIDVLVNNAGIAF-KWAAVEECSTDLAKTI 100
++K DI++ VKS +E V E + +LVN+A IA + + + S +L I
Sbjct: 77 RVIVVKADISEPSQVKSLFDEAERVFESP--VHILVNSAAIADPNHSTISDMSVELFDRI 134
Query: 101 FETNFFGVHRMTRAVLPHMREQRHGKIINIS-SMGGIMPIPYGALYCSSKHALEGYTESL 159
N G R ++ G+II +S S+ + YG+ Y +SK A+E + L
Sbjct: 135 ISVNTRGAFICAREAANRLKRGGGGRIILLSTSLVQTLNTNYGS-YTASKAAVEAMAKIL 193
Query: 160 DYEVKKFGIHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSL 212
E+K I V+ + P + T M Y + ++ E++ Q+L
Sbjct: 194 AKELKGTEITVNCVSPGPVATEM------------FYTGLSNEIVEKVKSQNL 234
>7293189 [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 598
Score = 56.2 bits (134), Expect = 5e-08
Identities = 48/186 (25%), Positives = 80/186 (42%), Gaps = 15/186 (8%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKL-----------D 52
+V ++TGA G+G A G +V G+ G S + +
Sbjct: 13 RVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEA 72
Query: 53 ITDEESV---KSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
+ D SV + I+ GR+D+LVNNAGI + V+ D + + + G
Sbjct: 73 VADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDW-NLVNDVHLKGSF 131
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
+ T+A P+M++Q +G+II SS GI Y ++K L G ++ E + +
Sbjct: 132 KCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVL 191
Query: 170 VSTIDP 175
+ I P
Sbjct: 192 CNVIVP 197
>At2g29330 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 55.8 bits (133), Expect = 6e-08
Identities = 48/188 (25%), Positives = 84/188 (44%), Gaps = 14/188 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVF-----GTSRKGSIPGKEYSFKMIKLDITD------ 55
L+TG ++GIG +I E L G ++ T S+ E + + D
Sbjct: 13 LVTGGASGIGHAIVEELAGFGAKIHVCDISKTLLNQSLSEWEKKGFQVSGSVCDASNRLE 72
Query: 56 EESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E++ V + + G++++LVNN G +E + D + I TN + +++
Sbjct: 73 RETLMQTVTTIFD--GKLNILVNNVGTIRTKPTIEYEAEDFSFLI-STNLESAYHLSQLS 129
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
P ++ +G I ISS GI+ ++Y +K AL +L E K GI + + P
Sbjct: 130 HPLLKASGNGIITFISSAAGIVSFDAASIYGLTKGALNQLARNLACEWAKDGIRANAVAP 189
Query: 176 HIIKTGMA 183
+ I T +A
Sbjct: 190 NFITTALA 197
>ECU08g1150 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 296
Score = 55.5 bits (132), Expect = 8e-08
Identities = 46/177 (25%), Positives = 82/177 (45%), Gaps = 15/177 (8%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKLDITDEESVK 60
++K+ ++I GA+ IG +A+ G +V R S ++I+L E +
Sbjct: 38 LRKKYVVINGATGKIGRGLAKKFAEKGMKVLLVGRSES--------RLIRLHAAIERMTE 89
Query: 61 SAVNEVIEKAGRIDVLVN--NAGIAFKWAAVEECST-----DLAKTIFETNFFGVHRMTR 113
++ V K ++ + GI A+ E S + I N GV +TR
Sbjct: 90 CHMHIVDYKRSNNLSFIDRYDVGILINCASTMEDSPAYFVEQSIEEIMNVNLVGVMSLTR 149
Query: 114 AVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV 170
VL +M + +G +INI S+ G P + + SK AL+ ++SL YE++ + ++V
Sbjct: 150 YVLVNMMDCGYGYVINIGSLMGEASTPLYSAFGCSKQALKALSDSLYYELEGYNVNV 206
>7290912 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 247
Score = 55.5 bits (132), Expect = 8e-08
Identities = 54/211 (25%), Positives = 95/211 (44%), Gaps = 26/211 (12%)
Query: 6 ILITGASTGIGLSIAETLRSAGY---EVFGTSRKGS-------IPGKEYSFKMIKLDITD 55
ILITG + G+GL + + L + +F T R + + ++++D+ +
Sbjct: 4 ILITGCNRGLGLGLVKALLNLPQPPQHLFTTCRNREQAKELEDLAKNHSNIHILEIDLRN 63
Query: 56 EESVKSAVNEV--IEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTR 113
++ V ++ + K ++VL NNAGIA K A + + +TN + +
Sbjct: 64 FDAYDKLVADIEGVTKDQGLNVLFNNAGIAPKSARITAVRSQELLDTLQTNTVVPIMLAK 123
Query: 114 AVLPHMREQRHGK-----------IINISS-MGGIMPIPYGALYC--SSKHALEGYTESL 159
A LP +++ IIN+SS +G I G +Y +SK AL T+SL
Sbjct: 124 ACLPLLKKAAKANESQPMGVGRAAIINMSSILGSIQGNTDGGMYAYRTSKSALNAATKSL 183
Query: 160 DYEVKKFGIHVSTIDPHIIKTGMANSNSPAD 190
++ I ++ P +KT M S++P D
Sbjct: 184 SVDLYPQRIMCVSLHPGWVKTDMGGSSAPLD 214
>7297912 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 299
Score = 55.1 bits (131), Expect = 1e-07
Identities = 48/195 (24%), Positives = 90/195 (45%), Gaps = 38/195 (19%)
Query: 4 QVILITGASTGIGLSIAETLRSAG-----YEVFGTSRKGSIP-------GKEYSFKMIKL 51
+++LITG GIG +A S G ++ G + ++ G+ YS+
Sbjct: 55 EIVLITGTGHGIGRELALHYASLGSTVVCVDIDGKNNLQTVEKAKRLNLGEVYSYSC--- 111
Query: 52 DITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRM 111
D++ + V + + + G I VLVNN GI +++ + ++ + +F+
Sbjct: 112 DVSKRDEVTALADRIKSDVGCISVLVNNVGIMPTHPILQQSAEEIQR-VFD--------- 161
Query: 112 TRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFG---- 167
E+ G II +SS+ G++ I YC++K A+ G E+L E+++
Sbjct: 162 ---------EKCRGHIICMSSIAGLVGISNLVPYCATKFAVRGLMEALHAELRQGPFRDL 212
Query: 168 IHVSTIDPHIIKTGM 182
I +TI P++ TG+
Sbjct: 213 IRTTTIFPYMTNTGL 227
>YOR246c [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 330
Score = 54.7 bits (130), Expect = 1e-07
Identities = 50/176 (28%), Positives = 79/176 (44%), Gaps = 36/176 (20%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK------------------------ 36
+++++ ++TG +TGIG L G+ V+ R
Sbjct: 14 VERKIAVVTGGNTGIGWYTVLHLYLHGFVVYICGRNSHKISKAIQEILAEAKKRCHEDDD 73
Query: 37 GSIPG--------KEYSFKMIKLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAA 88
GS PG + S I LD+TD + V+ A ++++ IDVLVNNAGI A
Sbjct: 74 GSSPGAGPGPSIQRLGSLHYIHLDLTDLKCVERAALKILKLEDHIDVLVNNAGI---MAV 130
Query: 89 VEECSTDLAKTIFETNFFGVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGAL 144
E + D + +TN+ T +LP +R R G+II++SS+G + Y L
Sbjct: 131 PLEMTKDGFEVQLQTNYISHFIFTMRLLPLLRHCR-GRIISLSSIGHHLEFMYWKL 185
>SPBC16H5.14c [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 286
Score = 54.7 bits (130), Expect = 1e-07
Identities = 67/259 (25%), Positives = 112/259 (42%), Gaps = 35/259 (13%)
Query: 3 KQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYS--FKMIKLDITDEESVK 60
K +I+ITG S +G +I + G+ V +Y+ F +K +IT ++ V+
Sbjct: 35 KGLIVITGGSGILGHAIIQEALDRGFSVASLDSTEPASFLQYNSKFSALKCNITKDKDVE 94
Query: 61 SAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVLPHMR 120
V+ + + L+N A IA K + +L K FETN G +T A+ P +
Sbjct: 95 GCVHSLKKMNRTPFALINAAAIAPKNHLLSISRQELQKC-FETNVIGQLAITSALFPLLL 153
Query: 121 EQRHGKIINI-SSMGGIMPIPYGALYCSSKHALEGYTESLDYEVK------KFGIHVSTI 173
+ + ++NI SS+ + GA Y SSK AL E+L+ EV KF ++V
Sbjct: 154 QDPNPHVVNIASSLAYFSAMGVGA-YSSSKAALVSLHETLEEEVLSQHPNFKFSLYVL-- 210
Query: 174 DPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDEPEVIAKEVLKVIKTEN 233
IK+ M ++P R+L L EP+ +AK +++ + T
Sbjct: 211 --GQIKSTMFEKDTP----------------NRVLAPLL----EPQNLAKIIIQNLYTNK 248
Query: 234 PKSRYTPGKAKLYAYFSYY 252
Y P A+ ++
Sbjct: 249 SGRFYYPFYARFMPLLRFF 267
>Hs5031765 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 54.7 bits (130), Expect = 1e-07
Identities = 57/215 (26%), Positives = 96/215 (44%), Gaps = 22/215 (10%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKM---------IKLDITDE 56
+++TGAS GIG +A L G V T+R K S + I + D
Sbjct: 37 VIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDM 96
Query: 57 ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVL 116
+ V + + G +D+L+ N + + K++ E NF +T A L
Sbjct: 97 TFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSM-EVNFLSYVVLTVAAL 155
Query: 117 PHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESL--DYEVKKFGIHVSTID 174
P M +Q +G I+ +SS+ G + P A Y +SK AL+G+ S+ +Y V + + ++
Sbjct: 156 P-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCV 214
Query: 175 PHIIKT--------GMANSNSPADEEMAVYDSIKG 201
+I T G+ + + EE A+ + IKG
Sbjct: 215 LGLIDTETAMKAVSGIVHMQAAPKEECAL-EIIKG 248
>At2g37540 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 321
Score = 54.3 bits (129), Expect = 2e-07
Identities = 48/193 (24%), Positives = 89/193 (45%), Gaps = 21/193 (10%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR--KGSIPGKEYSFKM--------IKLDITDE 56
+ITG ++GIGL A L G V +R K + KE +M +++D++
Sbjct: 37 IITGGTSGIGLEAARVLAMRGAHVIIAARNPKAANESKEMILQMNPNARVDYLQIDVSSI 96
Query: 57 ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVL 116
+SV+S V++ + +++L+NNAG+ F + + D ++ F TN G +T +L
Sbjct: 97 KSVRSFVDQFLALNVPLNILINNAGVMF---CPFKLTEDGIESQFATNHIGHFLLTNLLL 153
Query: 117 PHMREQR-----HGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFG--IH 169
M+ G+I+N+SS+ G + + GY+E Y K +H
Sbjct: 154 DKMKSTARESGVQGRIVNLSSIAHTYTYSEGIKF-QGINDPAGYSERRAYGQSKLSNLLH 212
Query: 170 VSTIDPHIIKTGM 182
+ + + + G+
Sbjct: 213 SNALSRRLQEEGV 225
>CE05118 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 325
Score = 53.9 bits (128), Expect = 2e-07
Identities = 72/294 (24%), Positives = 121/294 (40%), Gaps = 64/294 (21%)
Query: 1 MKKQVILITGASTGIGLS----IAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKL----- 51
+K ++ ++TGAS G G +A L AG ++ T R P K S ++ L
Sbjct: 3 LKSKIAIVTGASRGCGRGMLKGVALQLAEAGCTLYITGRA---PSKTLSSELTYLPTLEG 59
Query: 52 -----------------DITDEESVKSAVNEVI-EKAGRIDVLVNNAGIAFKWAAVEECS 93
D ++ + V+ +EV E ++D+LVNNA ++AV +C
Sbjct: 60 TAEECRKRGGICHVRYVDHSNMDEVEKFFDEVASETDNQLDILVNNA-----FSAVTKCG 114
Query: 94 TDLAKTIFET--------NFFGVHRMTRAVLPHMREQRH----GKIINISSMGGIMPIPY 141
+ + FE N G+ + R R G I+NISS+GGIM + +
Sbjct: 115 SGDTRKFFERDPEIWDDINNVGLRNQYYCSVYGTRIMRKNGMKGLIVNISSLGGIMYL-F 173
Query: 142 GALYCSSKHALEGYTESLDYEVKKFGIHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKG 201
Y K AL+ + + E++ GI V ++ P +KT + + + ++ G
Sbjct: 174 TVAYGVGKMALDRMSSDMAQELQDTGITVISLWPSAVKTELITN---------MIETSAG 224
Query: 202 KVSERMLKQSLENSDEPEVIAKEVLKVIKTENPKSRYTPGKAKLYA----YFSY 251
K L N + E K V+ + +PK +Y G + Y+SY
Sbjct: 225 SWGATENKMFL-NGESTEYCGKAVVAI--AADPKKKYWNGSTLITTDMGNYYSY 275
>At4g05530 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 254
Score = 53.5 bits (127), Expect = 3e-07
Identities = 44/192 (22%), Positives = 87/192 (44%), Gaps = 11/192 (5%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK--------GSIPGKEYSFKMIKLD 52
++ +V ++T ++ GIG I E G V +SRK + K I
Sbjct: 9 LEGKVAIVTASTQGIGFGITERFGLEGASVVVSSRKQANVDEAVAKLKSKGIDAYGIVCH 68
Query: 53 ITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMT 112
+++ + ++ V + ++K G+ID++V NA + + ++E N +
Sbjct: 69 VSNAQHRRNLVEKTVQKYGKIDIVVCNAAANPSTDPILSSKEAVLDKLWEINVKSSILLL 128
Query: 113 RAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVST 172
+ + PH+ ++ +I I+S+ G P A+Y +K AL G T++L E+ V+
Sbjct: 129 QDMAPHL--EKGSSVIFITSIAGFSPQGAMAMYGVTKTALLGLTKALAAEMAP-DTRVNA 185
Query: 173 IDPHIIKTGMAN 184
+ P + T A+
Sbjct: 186 VAPGFVPTHFAS 197
>CE02315 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 309
Score = 53.1 bits (126), Expect = 4e-07
Identities = 63/239 (26%), Positives = 104/239 (43%), Gaps = 25/239 (10%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMI----------- 49
+K +V L+TG TGIG +IA T G V +R+ + E + + I
Sbjct: 23 LKGKVALVTGGGTGIGKAIATTFAHLGASVAIAARR--MEKLEQTAEEIMKTTGGICEPF 80
Query: 50 KLDITDEESVKSAVNEVIEKAGR-IDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGV 108
++DI D V +++ +K G+ D+LVNNA F A E S + TI + G
Sbjct: 81 RMDIKDPGMVSDTFDKIDKKFGKHPDILVNNAAGNF-IMATERLSPNAHGTIIDIVLKGT 139
Query: 109 HRMTRAVLPHMREQRHG-KIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFG 167
+T + + + G + +I++ P+ SK +E T+SL E K+G
Sbjct: 140 MNVTTELGKRCIQSKTGASVTSITAAYARSGAPFIVPSAVSKAGVEIMTKSLATEWSKYG 199
Query: 168 IHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLE-NSDEPEVIAKEV 225
+ + + P I T A ++ G V+E+M + + E S PE +A V
Sbjct: 200 LRFNAVSPGPIPTKGAWGR--------LFSGEMGDVAEKMKELNPEGRSGTPEEVANLV 250
>Hs19923983 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 313
Score = 52.8 bits (125), Expect = 5e-07
Identities = 65/258 (25%), Positives = 107/258 (41%), Gaps = 43/258 (16%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSR-----------KGSIPGKEYSFKMI 49
M QV ++TGAS GIG IA L AG V+ T R S+ G+ +
Sbjct: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQ---CVPV 61
Query: 50 KLDITDEESVKSAVNEV-IEKAGRIDVLVNNAGIAFK----------WAAVEECSTDLAK 98
D + E V+S +V E+ GR+DVLVNNA + W D+
Sbjct: 62 VCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINN 121
Query: 99 TIFETNFFGVHRMTRAVLPHMREQRHGKIINISSMGGI---MPIPYGALYCSSKHALEGY 155
++F R ++P G I+ ISS G + +PYG K A +
Sbjct: 122 VGLRGHYFCSVYGARLMVP----AGQGLIVVISSPGSLQYMFNVPYGV----GKAACDKL 173
Query: 156 TESLDYEVKKFGIHVSTIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENS 215
+E+++ G+ ++ P I++T + E MA + ++ V + K + ++
Sbjct: 174 AADCAHELRRHGVSCVSLWPGIVQTELLK------EHMAKEEVLQDPVL-KQFKSAFSSA 226
Query: 216 DEPEVIAKEVLKVIKTEN 233
+ E+ K V+ + N
Sbjct: 227 ETTELSGKCVVALATDPN 244
>Hs19923931 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 260
Score = 52.8 bits (125), Expect = 5e-07
Identities = 35/143 (24%), Positives = 66/143 (45%), Gaps = 16/143 (11%)
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHR 110
LD+ +S++ ++IE+ R+D+L+NNAG+ + D + F N G
Sbjct: 25 LDLASLKSIREFAAKIIEEEERVDILINNAGV---MRCPHWTTEDGFEMQFGVNHLGHFL 81
Query: 111 MTRAVLPHMREQRHGKIINISSMGGI-------------MPIPYGALYCSSKHALEGYTE 157
+T +L ++ +IIN+SS+ + A YC SK A+ +T+
Sbjct: 82 LTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTK 141
Query: 158 SLDYEVKKFGIHVSTIDPHIIKT 180
L ++ G+ V+ + P + +T
Sbjct: 142 ELSRRLQGSGVTVNALHPGVART 164
>At2g29150 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 52.8 bits (125), Expect = 5e-07
Identities = 45/189 (23%), Positives = 87/189 (45%), Gaps = 15/189 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTS----------RKGSIPGKEYSFKMIKLDITDE 56
L+TG S G+G ++ E L G V + R+ G E + + + ++
Sbjct: 22 LVTGGSKGLGEAVVEELAMLGARVHTCARDETQLQERLREWQAKGFEVTTSVCDVSSREQ 81
Query: 57 -ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E + V+ V + G++++LVNNAG + E + D + + TN +++
Sbjct: 82 REKLMETVSSVFQ--GKLNILVNNAGTGIIKPSTEYTAEDYS-FLMATNLESAFHLSQIA 138
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
P ++ G I+ +SS+ G++ ++Y +SK A+ SL E I V+++ P
Sbjct: 139 HPLLKASGSGSIVFMSSVAGLVHTG-ASIYGASKGAMNQLGRSLACEWASDNIRVNSVCP 197
Query: 176 HIIKTGMAN 184
+I T + +
Sbjct: 198 WVITTPLTS 206
>7297516 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 256
Score = 52.8 bits (125), Expect = 5e-07
Identities = 50/241 (20%), Positives = 117/241 (47%), Gaps = 35/241 (14%)
Query: 6 ILITGASTGIGLSIAETLRSAGYEVFGTSRK-------GSIPGKEYSFKMI--KLDITDE 56
++ G+ +GIG + L ++ G + + S K++ ++++ ++
Sbjct: 9 VVYVGSFSGIGWQMMMQLMQKDIKMMGIMHRMENVKMMKKLQAINPSVKVVFMQMNLMEK 68
Query: 57 ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVL 116
S++ A+ ++ + G IDV++N G+ D+ +T N G+ + T +
Sbjct: 69 MSIEQAMKKMGQMMGHIDVMINGEGVLL--------DKDV-ETTMGMNLTGMIQSTMMAM 119
Query: 117 PHMREQRHGK---IINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEV--KKFGIHVS 171
P+M + + G ++N+SS+ G+ P P ++Y ++ H + G+T S+ ++ +K G+
Sbjct: 120 PYMDKTQMGMGGMVVNMSSVYGLEPAPAFSVYAAAMHGILGFTRSMGDKMIYQKTGVMFM 179
Query: 172 TIDPHIIKTGMANSNSPADEEMAVYDSIKGKVSERMLKQSLENSDE--PEVIAKEVLKVI 229
+ P G+ NS + M + D++ SE M+ +++E++ PE A +++ +
Sbjct: 180 AMCP-----GLTNS----EMIMNLRDNVTWHHSESMV-EAIESAKRQMPEEAAMQMIHAM 229
Query: 230 K 230
+
Sbjct: 230 E 230
>At2g29290 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 52.4 bits (124), Expect = 7e-07
Identities = 44/211 (20%), Positives = 93/211 (43%), Gaps = 21/211 (9%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTS----------RKGSIPGKEYSFKMIKLDITDE 56
L+TG + GIG ++ E L G V + R+ G + + + + + ++
Sbjct: 13 LVTGGTKGIGEAVVEELSILGARVHTCARDETQLQERLREWQEKGFQVTTSICDVSLREQ 72
Query: 57 -ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E + V+ + + G++++LVNN G E + + + + TN +++
Sbjct: 73 REKLMETVSSLFQ--GKLNILVNNVGTLMLKPTTEYTAEEFS-FLMATNLDSAFHISQLA 129
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
P ++ G I+ +SS+ G++ + G++Y ++K A+ +L E I + I P
Sbjct: 130 HPLLKASGSGSIVLMSSIAGVVHVGVGSIYGATKGAMNQLARNLACEWASDNIRTNAICP 189
Query: 176 HIIKTGMANSNSPADEEMAVYDSIKGKVSER 206
+I T P ++ + +K + ER
Sbjct: 190 WLITT-------PLISDLLSVEEMKKEAEER 213
>YKL071w [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 256
Score = 51.2 bits (121), Expect = 1e-06
Identities = 48/192 (25%), Positives = 88/192 (45%), Gaps = 18/192 (9%)
Query: 8 ITGASTGIGLSIAETLRSAGYEVFGTSRKGS--IPGKEY---------SFKMIKLDITDE 56
I G S GIG ++ + L ++ TS +GS +P + + +++LD+T +
Sbjct: 11 IIGGSRGIGFNLVKILSASTGNTVITSIRGSPSLPKNKQVEDLAKIRKNIHIVQLDLTKD 70
Query: 57 ESVKSAVNEVIEKAG--RIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRA 114
ES+ + +E+ + ID+ + + ++ + V E + + TN G +
Sbjct: 71 ESIGNIADEIKKTPFFLGIDIFIACSAVSDSYYKVLETPKSVWLNHYSTNALGPILALQK 130
Query: 115 VLPHMREQRHGKIINISSMGG----IMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHV 170
V P + ++ KI ISS+ G +P+ A Y SK AL ++L +E+K G V
Sbjct: 131 VYPLLLLKKTRKIFFISSVAGSINAFVPLSVSA-YGQSKAALNYAVKTLSFELKPEGFTV 189
Query: 171 STIDPHIIKTGM 182
P ++ T M
Sbjct: 190 VAFHPGMVSTDM 201
>SPAC22A12.17c [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 51.2 bits (121), Expect = 1e-06
Identities = 47/187 (25%), Positives = 85/187 (45%), Gaps = 16/187 (8%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMI----------K 50
+K + ++ G + GIG +I AG F + PG++ + ++ K
Sbjct: 19 LKGKNAVVFGGARGIGHAICSVFAEAGANAFIVYN--TTPGEKAAKEIAQANGVKTYTCK 76
Query: 51 LDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHR 110
D+T + V+ A E+ + ID++V N GI +A++ + A I N GV
Sbjct: 77 CDVTIPKEVEHAFAEIQKVFDTIDIVVPNNGICTGKSAIDMTYEEFANEI-NVNLLGVFN 135
Query: 111 MTRAVLPHMREQRHGKIINISSMGG-IMPIP-YGALYCSSKHALEGYTESLDYEVKKFGI 168
+ P ++Q HG ++ +SM G ++ +P Y +SK + +SL E +KF
Sbjct: 136 VAHNAGPIFQKQGHGSLVATASMSGVVVNVPQQQCAYNTSKAGVIQLIKSLAVEWRKFA- 194
Query: 169 HVSTIDP 175
V+ + P
Sbjct: 195 RVNCVSP 201
>Hs10190704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 292
Score = 51.2 bits (121), Expect = 1e-06
Identities = 47/186 (25%), Positives = 82/186 (43%), Gaps = 14/186 (7%)
Query: 1 MKKQVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMI----------- 49
++ +V ITG +GIG IAE G SR S+P + + +
Sbjct: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASR--SLPRVLTAARKLAGATGRRCLPL 83
Query: 50 KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
+D+ +V +AV++ +++ GRID+L+N A F A S + KT+ + + G
Sbjct: 84 SMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPA-GALSFNAFKTVMDIDTSGTF 142
Query: 110 RMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIH 169
++R + G I+NI++ G S+K A++ T L E I
Sbjct: 143 NVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIR 202
Query: 170 VSTIDP 175
V+++ P
Sbjct: 203 VNSLAP 208
>At5g50130 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 51.2 bits (121), Expect = 1e-06
Identities = 51/212 (24%), Positives = 94/212 (44%), Gaps = 35/212 (16%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR--------KGSI--PGKEYSFKMIKLDITDE 56
+ITG ++GIG A L G V R K I E + ++D++
Sbjct: 40 IITGGTSGIGAETARVLAKRGVRVVMAVRDMKKAEMVKERIIRENPEADIILFEIDLSSL 99
Query: 57 ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVL 116
SV ++ + + +++L+NNAG+ ++ E S + + F TNF G + +T ++
Sbjct: 100 SSVARFCSQFLSQDLPLNILINNAGV---FSPNLEFSEEKIELTFATNFLGHYLLTEMLI 156
Query: 117 PHM-----REQRHGKIINISSM-------------GGIMPIPYGA--LYCSSKHALEGYT 156
M + G+IIN+SS+ + PI Y Y SK A +
Sbjct: 157 EKMIDTAEKSGIEGRIINLSSVIHNWVKPDCFSFPKLLHPIRYNGTRAYAQSKLATILHA 216
Query: 157 ESLDYEVK--KFGIHVSTIDPHIIKTGMANSN 186
++L ++K + ++ + P I+KTG+ ++
Sbjct: 217 KALSKQLKDRNANVTINAVHPGIVKTGIIRAH 248
>At2g29370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 51.2 bits (121), Expect = 1e-06
Identities = 41/185 (22%), Positives = 80/185 (43%), Gaps = 14/185 (7%)
Query: 7 LITGASTGIGLSIAETLRSAGYEVFGTSR----------KGSIPGKEYSFKMIKLDITDE 56
L+TG S G+G ++ E L G V +R + G + + + + D+
Sbjct: 22 LVTGGSKGLGKAVVEELAMLGARVHTCARDETQLQESLREWQAKGLQVTTSVCDVSSRDQ 81
Query: 57 -ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
E + V+ + + G++ +LV N GI EC+ + I TN ++
Sbjct: 82 REKLMETVSSLFQ--GKLSILVPNVGIGVL-KPTTECTAEEFSFIIATNLESTFHFSQLA 138
Query: 116 LPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGIHVSTIDP 175
P ++ G I+ +SS+ G++ + ++Y ++K A+ +L E I +++ P
Sbjct: 139 HPLLKASGSGNIVLMSSVAGVVNLGNTSIYGATKGAMNQLARNLACEWASDNIRANSVCP 198
Query: 176 HIIKT 180
I T
Sbjct: 199 WFITT 203
>7290022 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 330
Score = 50.8 bits (120), Expect = 2e-06
Identities = 52/198 (26%), Positives = 93/198 (46%), Gaps = 30/198 (15%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKG--SIPGK---------EYSFKMI--- 49
+V+LIT A T +GL + L + GY VF ++ S+P K EYS + I
Sbjct: 46 RVVLITSADTALGLQLCTHLANKGYRVFAGMKEAQDSLPAKLLCGWMKIREYSEEPIAGT 105
Query: 50 ----KLDITDEESVKSA-----VNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTI 100
+LD+T E+ ++ A N ++ G I ++N +G F+ VE + + +
Sbjct: 106 IIPMRLDVTREDVLREATVIIGANLNADERG-IAAVINTSGSVFR-GQVESQNVQQWEHM 163
Query: 101 FETNFFGVHRMTRAVLPHMREQRHGKIINISSM-GGIMPIPYG---ALYCSSKHALEGYT 156
TN G R+ +A + +R R G+++ + + GG G + +S+ A++
Sbjct: 164 LRTNILGTLRVAKAFVCFLRPTR-GRLLYLGGVSGGGNARNEGDGLVAFNASRVAVDKCA 222
Query: 157 ESLDYEVKKFGIHVSTID 174
E L E+ +G+ V +D
Sbjct: 223 EELRKELHPYGVSVVALD 240
>At4g13180 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 263
Score = 50.4 bits (119), Expect = 3e-06
Identities = 50/194 (25%), Positives = 92/194 (46%), Gaps = 17/194 (8%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEV----FGTSRKGSIPGKEY-------SFKMIKLD 52
+V ++TGA+ G+G IA L S G V +S K + E S +K D
Sbjct: 16 RVAIVTGATRGMGREIAIHLHSLGARVTINYVSSSSKAELLVSELNDSSQLKSAIAVKAD 75
Query: 53 ITDEESVKSAVNEVIEKAG-RIDVLVNNAGIAF-KWAAVEECSTDLAKTIFETNFFGVHR 110
++D + + + ++ ++ G ++ ++VN AG+ K+ ++ E + + F N G
Sbjct: 76 VSDPDQINNLFDQTEQEFGSKVHIVVNCAGVLDPKYPSLSETTLEDFDNTFTINTRGSFL 135
Query: 111 MTRAVLPHMREQRHGKIINISS--MGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
+ + G+II +S+ +GG+ P YG +Y +SK A+E + L E+K I
Sbjct: 136 CCKEAAKRVMRGGGGRIIMMSTSMVGGLAP-GYG-VYAASKAAVETMVKVLAKELKGSRI 193
Query: 169 HVSTIDPHIIKTGM 182
+ + P + T M
Sbjct: 194 TANCVAPGPVATEM 207
>Hs10190746 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 336
Score = 50.1 bits (118), Expect = 3e-06
Identities = 54/217 (24%), Positives = 97/217 (43%), Gaps = 38/217 (17%)
Query: 1 MKKQVILITGASTGIGLSIAETL-------------RSAGYEVFGTSRK--------GSI 39
M + +LITGA++G+G + A L R+ E G R+ G
Sbjct: 41 MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPE 100
Query: 40 PGKEYSFKMI--KLDITDEESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLA 97
PG ++I +LD+ SV++ E++++ R+DVL+NNAGI F+ ++ + D
Sbjct: 101 PGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGI-FQCPYMK--TEDGF 157
Query: 98 KTIFETNFFGVHRMTRAVLPHMREQRHGKIINISS----MGGI------MPIPYGALYCS 147
+ F N G +T +L ++ +I+ +SS G I Y +C
Sbjct: 158 EMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCY 217
Query: 148 SKHALEG--YTESLDYEVKKFGIHVSTIDPHIIKTGM 182
S+ L +T L ++ + V+ + P I++T +
Sbjct: 218 SRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNL 254
>CE02370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 309
Score = 50.1 bits (118), Expect = 3e-06
Identities = 55/206 (26%), Positives = 90/206 (42%), Gaps = 20/206 (9%)
Query: 2 KKQVILITGASTGIGLSIAETLRSAGYEVFGTSRK-----------GSIPGKEYSFKMIK 50
K +++L+TG TGIG +IA T V +R+ I G + + +
Sbjct: 24 KGKLVLVTGGGTGIGKAIATTFAHLRATVVIAARRMEKLEQTARDITKITGG--TCEPFQ 81
Query: 51 LDITDEESVKSAVNEVIEKAGRI-DVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVH 109
+DI D V A +++ K G++ ++LVNNA F A E S++ TI + G
Sbjct: 82 MDIKDPGMVSDAFDKIDMKFGKVPEILVNNAAGNF-IMATELLSSNAYGTIIDIVLKGTF 140
Query: 110 RMTRAVLPHMREQRHG-KIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYEVKKFGI 168
+T + + + G I +I++ P+ SK +E T+SL E K+G+
Sbjct: 141 NVTTELGKRCIQNKTGASITSITAGYARAGAPFIVPSAVSKAGVETMTKSLATEWSKYGL 200
Query: 169 HVSTIDPHIIKT----GMANSNSPAD 190
+ + P I T G NS D
Sbjct: 201 RFNAVSPGPIPTKGAWGRLNSGEMGD 226
>7290386 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 176
Score = 50.1 bits (118), Expect = 3e-06
Identities = 46/166 (27%), Positives = 80/166 (47%), Gaps = 12/166 (7%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIP-------GKEYSFKMIKLDITDE 56
+V L+TGA +GIG + L G +V R G E S +++D++
Sbjct: 9 KVALVTGAGSGIGRATCRLLARDGAKVIAVDRNLKAAQETVQELGSERS-AALEVDVSSA 67
Query: 57 ESVKSAVNEVIEKAGRI-DVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAV 115
+SV+ +V E ++K + ++VN+AGI ++ D ++ N G +T+A
Sbjct: 68 QSVQFSVAEALKKFQQAPTIVVNSAGITRDGYLLKMPERDY-DDVYGVNLKGTFLVTQAY 126
Query: 116 LPHMREQR--HGKIINISSMGGIMPIPYGALYCSSKHALEGYTESL 159
M EQ+ +G I+N+SS+ M A Y ++K + +TE L
Sbjct: 127 AKAMIEQKLENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTERL 172
>CE28036 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 378
Score = 49.7 bits (117), Expect = 4e-06
Identities = 29/83 (34%), Positives = 42/83 (49%), Gaps = 2/83 (2%)
Query: 100 IFETNFFGVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESL 159
I N G VLP M + G+I+ +SS G+ PIP A YC++K + ES+
Sbjct: 193 ILRVNGMGAAEFLSCVLPPMEKSGGGQIVVLSSSQGVRPIPMLAAYCATKALMTFLCESI 252
Query: 160 DYEVKKFGIHVSTIDPHIIKTGM 182
D E I+V T+ P ++ T M
Sbjct: 253 DREYST--INVQTLIPALVATKM 273
>At3g03980 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 49.7 bits (117), Expect = 4e-06
Identities = 57/224 (25%), Positives = 98/224 (43%), Gaps = 23/224 (10%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVF--GTSR----------------KGSIPGKEYS 45
+V ++TG+S GIG +IA L G + TS+ + I GK
Sbjct: 17 RVAIVTGSSRGIGRAIAIHLAELGARIVINYTSKAADAERVASEINDFPVREEITGKGPR 76
Query: 46 FKMIKLDITDEESVKSAVNEVIEKA--GRIDVLVNNAGIAF-KWAAVEECSTDLAKTIFE 102
+++ ++++ VKS + E A + +LVN+AGI K+ + + S + F
Sbjct: 77 AIVVQANVSEPSQVKSMF-DAAESAFEAPVHILVNSAGILDPKYPTIADTSVEDFDHTFS 135
Query: 103 TNFFGVHRMTRAVLPHMREQRHGKIINISSMGGIMPIPYGALYCSSKHALEGYTESLDYE 162
N G ++ +++ G+II ++S P Y +SK A+E + L E
Sbjct: 136 VNTKGAFLCSKEAANRLKQGGGGRIILLTSSQTRSLKPGFGAYAASKAAVETMVKILAKE 195
Query: 163 VKKFGIHVSTIDPHIIKTGM-ANSNSPADEEMAVYDSIKGKVSE 205
+K GI + + P I T M + +P E +S G+V E
Sbjct: 196 LKGTGITANCVAPGPIATEMFFDGKTPELVEKIAAESPFGRVGE 239
>7290709 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 406
Score = 49.7 bits (117), Expect = 4e-06
Identities = 48/206 (23%), Positives = 83/206 (39%), Gaps = 38/206 (18%)
Query: 4 QVILITGASTGIGLSIAETLRSAGYEVFGTSRKGSIPGKEYSFKMIKLDITDE------- 56
+V+++TG +TGIG L G V+ R PG+ + +LDI D
Sbjct: 75 KVVIVTGCNTGIGKETVLELAKRGARVYMACRD---PGR---CEAARLDIMDRSRNQQLF 128
Query: 57 ---------ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFG 107
+SV++ V + R+D+L+NNAG+ A + D + F N G
Sbjct: 129 NRTLDLGSLQSVRNFVERFKAEESRLDILINNAGV---MACPRTLTADGFEQQFGVNHLG 185
Query: 108 VHRMTRAVLPHMREQRHGKIINISSMGGIMP-------------IPYGALYCSSKHALEG 154
+T +L ++ +I+ +SS + + Y SK A
Sbjct: 186 HFLLTNLLLDRLKHSSPSRIVVVSSAAHLFGRINREDLMSEKNYSKFFGAYSQSKLANIL 245
Query: 155 YTESLDYEVKKFGIHVSTIDPHIIKT 180
+T L +K G+ V+ P +++T
Sbjct: 246 FTLKLSTILKDTGVTVNCCHPGVVRT 271
>7298168 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 272
Score = 48.5 bits (114), Expect = 1e-05
Identities = 32/106 (30%), Positives = 50/106 (46%), Gaps = 12/106 (11%)
Query: 57 ESVKSAVNEVIEKAGRIDVLVNNAGIAFKWAAVEECSTDLAKTIFETNFFGVHRMTRAVL 116
E +K +EV+ + IDVL+N A + C + TN G+ VL
Sbjct: 70 EDMKKYFDEVMVQMDYIDVLINGATL---------CDENNIDATINTNLTGMMNTVATVL 120
Query: 117 PHMREQRHGK---IINISSMGGIMPIPYGALYCSSKHALEGYTESL 159
P+M + G I+N++S+ G+ P P Y +SK + G+T SL
Sbjct: 121 PYMDRKMGGTGGLIVNVTSVIGLDPSPVFCAYSASKFGVIGFTRSL 166
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.133 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,125,245
Number of Sequences: 60738
Number of extensions: 606032
Number of successful extensions: 2715
Number of sequences better than 1.0e-05: 231
Number of HSP's better than 0.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 198
Number of HSP's that attempted gapping in prelim test: 2307
Number of HSP's gapped (non-prelim): 241
length of query: 268
length of database: 30,389,216
effective HSP length: 105
effective length of query: 163
effective length of database: 24,011,726
effective search space: 3913911338
effective search space used: 3913911338
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)