ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV2639 good L KOG1294 Replication, recombination and repair Apurinic/apyrimidinic endonuclease and related enzymes
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV2639 922357 923853 499
(499 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBL019w [L] KOG1294 Apurinic/apyrimidinic endonuclease and relat... 484 e-137
SPBC3D6.10 [L] KOG1294 Apurinic/apyrimidinic endonuclease and re... 184 2e-46
Hs18375507 [L] KOG1294 Apurinic/apyrimidinic endonuclease and re... 152 1e-36
At4g36050 [L] KOG1294 Apurinic/apyrimidinic endonuclease and rel... 84 5e-16
ECU06g1360 [L] KOG1294 Apurinic/apyrimidinic endonuclease and re... 77 8e-14
CE16306 [L] KOG1294 Apurinic/apyrimidinic endonuclease and relat... 53 1e-06
>YBL019w [L] KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes
Length = 520
Score = 484 bits (1247), Expect = e-137
Identities = 244/509 (47%), Positives = 346/509 (67%), Gaps = 16/509 (3%)
Query: 5 KDKTGVRFVTFNVNGVRTLFQHYPFSRMNNSLKLAFELFQADIVTLQELKIDAKSISKWG 64
K + +RF+TFNVNG+RT F + PFS+MN SL+ F+ F+ADI+T QELK + SISKWG
Sbjct: 12 KSENTIRFLTFNVNGIRTFFHYQPFSQMNQSLRSVFDFFRADIITFQELKTEKLSISKWG 71
Query: 65 KVEGYQSYITISQKRKGYSGVGCWIRTPSEDDPLRHHLKVIKAEEGITGLLRVQA---NG 121
+V+G+ S+I+I Q RKGYSGVGCWIR P ++ PL H L+V+KAEEGITG L ++ +
Sbjct: 72 RVDGFYSFISIPQTRKGYSGVGCWIRIPEKNHPLYHALQVVKAEEGITGYLTIKNGKHSA 131
Query: 122 ISYRES-SEGIGGYTGLD-FADENDLLDIDSEGRCIIIELACNVVIFSTYCPANSSQTEE 179
ISYR ++GIGGY LD DE L++DSEGRC+++ELAC +VI S YCPANS+ +EE
Sbjct: 132 ISYRNDVNQGIGGYDSLDPDLDEKSALELDSEGRCVMVELACGIVIISVYCPANSNSSEE 191
Query: 180 GELSRLTFLKLLFKRIRNLHGLGKHVVLMGDINVCRDLKDHATALDESSISLSQQKTGSE 239
GE+ RL FLK+L +R+RNL +GK +VLMGD+NVCRDL D A L++ SI ++ G++
Sbjct: 192 GEMFRLRFLKVLLRRVRNLDKIGKKIVLMGDVNVCRDLIDSADTLEQFSIPITDPMGGTK 251
Query: 240 IEEKFNEKCVQFIMDPSRIGRRLLNTMLCDSIISKYAQEGILVDSTRKIQGRDRLKMYTV 299
+E ++ +K +QFI++P RR+ N +L DS++ ++ GIL+D+TR IQ R+RLKMYTV
Sbjct: 252 LEAQYRDKAIQFIINPDTPHRRIFNQILADSLLPDASKRGILIDTTRLIQTRNRLKMYTV 311
Query: 300 WNTLLNTRPVNYGSRVDYIFVSKGLKDNITDGDILTTIMGSDHCPVFADIKV--DNLELK 357
WN L N RP NYGSR+D+I VS L+ I DIL I+GSDHCPV++D+ + D +E
Sbjct: 312 WNMLKNLRPSNYGSRIDFILVSLKLERCIKAADILPDILGSDHCPVYSDLDILDDRIEPG 371
Query: 358 HESFNKPKFEAATRYFLNHGNILDMF-RKANRKXXXXXXXXXGKVV---KPLNVKQYNGM 413
PKFEA +Y L + N+L+MF +K K KV+ K N+K +
Sbjct: 372 TTQVPIPKFEARYKYNLRNHNVLEMFAKKDTNKESNKQKYCVSKVMNTKKNSNIKNKSLD 431
Query: 414 NALASATVSKD----QNKNVSIQPQSRVKSAHMKAFEEMLGKAPVCEHGEEAVLRVSKTD 469
+ KD ++ + Q + R+ + + F+++ GK P+C HGEE++L+ SKT
Sbjct: 432 SFFQKVNGEKDDRIKESSEIPQQAKKRISTPKLN-FKDVFGKPPLCRHGEESMLKTSKTS 490
Query: 470 KSFGKKFWVCNRSKGEKDDPEASCGFFQW 498
+ G+KFW+C RS+G+ ++ E+SCGFFQW
Sbjct: 491 ANPGRKFWICKRSRGDSNNTESSCGFFQW 519
>SPBC3D6.10 [L] KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes
Length = 523
Score = 184 bits (468), Expect = 2e-46
Identities = 157/557 (28%), Positives = 248/557 (44%), Gaps = 112/557 (20%)
Query: 10 VRFVTFNVNGVRTLFQHYPFSRMNNSLKLAFELFQADIVTLQELKIDAKSI-SKWGKVEG 68
+R +++NVNG++ F ++P+++ NS K F+ QAD++ +QELK+ S ++ VEG
Sbjct: 1 MRILSWNVNGIQNPFNYFPWNK-KNSYKEIFQELQADVICVQELKMQKDSFPQQYAVVEG 59
Query: 69 YQSYITISQKRKGYSGVGCWIRTPSEDDPLRHHLKVIKAEEGITGLLRVQANGISYRESS 128
+ SY T + RKGYSGVG +++ + +KAEEGITG+L V+ SY E+
Sbjct: 60 FDSYFTFPKIRKGYSGVGFYVK--------KDVAIPVKAEEGITGILPVRGQKYSYSEAP 111
Query: 129 EGIG-GYTGLDFADENDLLDIDSEGRCIIIELACNVVIFSTYCPANSSQTEEGELS-RLT 186
E G+ D D IDSEGRCI+++ ++I YCP NS E L R
Sbjct: 112 EHEKIGFFPKDI-DRKTANWIDSEGRCILLDFQMFILI-GVYCPVNSG---ENRLEYRRA 166
Query: 187 FLKLLFKRIRNLHGLG-KHVVLMGDINVCRDLKDHATALDESSISLSQQKTGSEIEEKFN 245
F K L +RI L G + ++L+GD+N+ + D A D+ I
Sbjct: 167 FYKALRERIERLIKEGNRKIILVGDVNILCNPIDTA---DQKDI--------------IR 209
Query: 246 EKCVQFIMDPSRIGRRLLNTMLCDSIISKYAQEGILVDSTRKIQGRDRLKMYTVWNTLLN 305
E + IM+ R+ + +L S + G+L+D R IQ R M+T WNT LN
Sbjct: 210 ESLIPSIME----SRQWIRDLLLPSRL------GLLLDIGR-IQHPTRKGMFTCWNTRLN 258
Query: 306 TRPVNYGSRVDYIFVSKGLKDNITDGDILTTIMGSDHCPVFADIKVDN------------ 353
TRP NYG+R+DY + L + D DI+ +MGSDHCPV+ D+K +
Sbjct: 259 TRPTNYGTRIDYTLATPDLLPWVQDADIMAEVMGSDHCPVYLDLKEEYEGKKLSNFLSHS 318
Query: 354 -----LELKHESFNKPK------FEAATRYFLNHGNILDMFRKANRKXXXXXXXXXGKVV 402
L H S +P F+ N N + +
Sbjct: 319 KEPPLLSTAHHSAYRPSKNIHSMFQHFNSMKKNKNNSPTQSENVSASASSGSSPTVSRAN 378
Query: 403 KPLNVKQY---------------------------NGMNALASATVSKDQNKNVSIQPQS 435
++V Y N ++ + + ++ + +
Sbjct: 379 SVIDVDAYPPEKRRRKEQSKLLSFFAKQKEEKEETNKTEDVSIEVLDNNNESDIGLTVKK 438
Query: 436 RVKSAHMKAFEEMLGK--APVCEHGEE--AVLRVSKTDKSFGKKFWVCNRSKG------- 484
+V++ + A++++ + P+CE +E L V K ++G+KFW+C R G
Sbjct: 439 KVENGN--AWKQIFSERAPPLCEGHKEPCKYLTVRKPGINYGRKFWICARPVGELIKNSN 496
Query: 485 ---EKDDPEASCGFFQW 498
E+D C FF W
Sbjct: 497 AVSEEDTQPFQCRFFIW 513
>Hs18375507 [L] KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes
Length = 518
Score = 152 bits (384), Expect = 1e-36
Identities = 144/557 (25%), Positives = 230/557 (40%), Gaps = 112/557 (20%)
Query: 10 VRFVTFNVNGVRTLFQHYPFSRMNNSLKLA----FELFQADIVTLQELKIDAKSISK-WG 64
+R V++N+NG+R Q +N +A + ADIV LQE K+ ++++
Sbjct: 2 LRVVSWNINGIRRPLQGVANQEPSNCAAVAVGRILDELDADIVCLQETKVTRDALTEPLA 61
Query: 65 KVEGYQSYITISQKRKGYSGVGCWIRTPSEDDPLRHHLKVIKAEEGITGLLRVQANGISY 124
VEGY SY + S+ R GYSGV + + + + AEEG++GL Q NG
Sbjct: 62 IVEGYNSYFSFSRNRSGYSGVATFCKDNATP---------VAAEEGLSGLFATQ-NG--- 108
Query: 125 RESSEGIGGYTGLDFADENDLLDIDSEGRCIIIELACN--------VVIFSTYCPANSSQ 176
+G Y +D + +L +DSEGR ++ + + + + YCP
Sbjct: 109 -----DVGCYGNMDEFTQEELRALDSEGRALLTQHKIRTWEGKEKTLTLINVYCPHADPG 163
Query: 177 TEEGELSRLTFLKLLFKRIRNLHGLGKHVVLMGDINVCRDLKDHATALDESSISLSQQKT 236
E + ++ F +LL R L G HV+++GD+N DH A+
Sbjct: 164 RPERLVFKMRFYRLLQIRAEALLAAGSHVIILGDLNTAHRPIDHWDAV------------ 211
Query: 237 GSEIEEKFNEKCVQFIMDPSRIGRRLLNTMLCDSIISKYAQEGILVDSTRKIQGRDRLKM 296
N +C F DP GR+ ++++L + + G +DS R Q +
Sbjct: 212 --------NLEC--FEEDP---GRKWMDSLLSNLGCQSASHVGPFIDSYRCFQPKQE-GA 257
Query: 297 YTVWNTLLNTRPVNYGSRVDYIFVSKGLK-DNITDGDILTTIMGSDHCPVFADIKVDNL- 354
+T W+ + R +NYGSR+DY+ + L D +L +MGSDHCPV A + V ++
Sbjct: 258 FTCWSAVTGARHLNYGSRLDYVLGDRTLVIDTFQASFLLPEVMGSDHCPVGAVLSVSSVP 317
Query: 355 ------------------ELKHESF-----NKPKFEAATRYFLNHGNILDMFRKANRKXX 391
+LK F P E +T N + KA +
Sbjct: 318 AKQCPPLCTRFLPEFAGTQLKILRFLVPLEQSPVLEQSTLQHNNQTRVQTCQNKAQVRST 377
Query: 392 XXXXXXXGKVVKPLNVKQYNG-------------------MNAL---------ASATVSK 423
G N+K Y M+AL A A V K
Sbjct: 378 RPQPSQVGSSRGQKNLKSYFQPSPSCPQASPDIELPSLPLMSALMTPKTPEEKAVAKVVK 437
Query: 424 DQNKNVSIQPQSRVKSAHMKAFEEMLGKAPVC-EHGEEAVLR-VSKTDKSFGKKFWVCNR 481
Q K + + ++++ K+ + P+C H E V+R V K + G++F++C R
Sbjct: 438 GQAKTSEAKDEKELRTSFWKSVLAGPLRTPLCGGHREPCVMRTVKKPGPNLGRRFYMCAR 497
Query: 482 SKGEKDDPEASCGFFQW 498
+G DP + C FF W
Sbjct: 498 PRGPPTDPSSRCNFFLW 514
>At4g36050 [L] KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes
Length = 641
Score = 84.0 bits (206), Expect = 5e-16
Identities = 66/219 (30%), Positives = 105/219 (47%), Gaps = 17/219 (7%)
Query: 10 VRFVTFNVNGVRTLFQHYPFSRMNNSLKLAFELFQADIVTLQELKIDAKSISK-WGKVEG 68
++ VT+NVNG+R + +SL + F ADI+ QE K+ + ++ +G
Sbjct: 1 MKIVTYNVNGLRQRVSQF------DSLLKLLDSFDADIICFQETKLRRQELTADLAIADG 54
Query: 69 YQSYI----TISQKRKGYSGVGCWIRTPSEDDPLRHHLKVIKAEEGITGLLRVQANGISY 124
Y+S+ T + R GYSGV + R S L V AEEGITGL+ + G
Sbjct: 55 YESFFSCTRTSEKGRTGYSGVATFCRVKSASSSCETALPVT-AEEGITGLVNSNSRGGKS 113
Query: 125 RESSEGIGGYTGLDFADENDLLDIDSEGRCIIIELACNVVIFSTYCPANSSQTEEGELSR 184
S+ GL+ ++ +LL ID EGRC+I + + V+F+ Y P + + +
Sbjct: 114 ETSTVA----EGLEEYEKEELLMIDQEGRCVITDHG-HFVVFNVYGPRAVADDADRIEFK 168
Query: 185 LTFLKLLFKRIRNLHGLGKHVVLMGDINVCRDLKDHATA 223
F +L +R L G+ V ++GD+N+ D A
Sbjct: 169 HRFYGVLERRWECLLRQGRRVFVVGDLNIAPFAMDRCEA 207
>ECU06g1360 [L] KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes
Length = 338
Score = 76.6 bits (187), Expect = 8e-14
Identities = 85/388 (21%), Positives = 156/388 (39%), Gaps = 83/388 (21%)
Query: 10 VRFVTFNVNGVRTLFQHYPFS---RMNNSLKLAFELFQADIVTLQELKIDAKSISKWGKV 66
+R +FNVNG+R+ ++ S R N +K + +ADI+ +QE + ++ ++ +
Sbjct: 18 MRITSFNVNGIRSFSKYVMKSCRLRFNEYVK---NILRADILCVQETRGREGALGEFHSL 74
Query: 67 EGYQSYITISQKRKGYSGVGCWIRTPSEDDPLRHHLKVIKAEEGITGLLRVQANGISYRE 126
Y ++ ++ SGV + ++ G+
Sbjct: 75 RDYITFTNTNKTNSSRSGVSTMVSK------------------------KLYCRGVLDSP 110
Query: 127 SSEGIGGYTGLDFADENDLLDIDSEGRCIIIELACNVVIFSTYCPANSSQTEEGELSRLT 186
+E +GR ++ + + + Y P +E + +
Sbjct: 111 FAE---------------------DGRSLLTDHG-EFKVLNLYFPFFDESSERDKSEVIG 148
Query: 187 FLKLLFKRIRNLHGLGKHVVLMGDINVCRDLKDHATALDESSISLSQQKTGSEIEEKFNE 246
F + + IR ++++ GD N + DH E + Q+K +EE E
Sbjct: 149 FYDAIGEFIRG----HDNIIMCGDFNAVYSIIDHYQFYSE--LLRIQRKDRPGLEEGAKE 202
Query: 247 KCVQFIMDPSRI-------GRRLLNTMLCDSIISKYAQE----GILVDSTRKIQGRDRLK 295
+ + P+R+ L + L ++ K+ + G +D+ R + R +
Sbjct: 203 RR-RARKSPTRLELPYEFYAEDALESYLLETEQRKWLRSLIDGGEYIDAYRALCKRP--E 259
Query: 296 MYTVWNTLLNTRPVNYGSRVDYIFVSKGLKDNITDGDILTTIMGSDHCPVFADIKVDNLE 355
YT WNT+LN RP N G+R+DYI + + + D DI I GSDHCPV+A+I D ++
Sbjct: 260 SYTCWNTMLNLRPRNLGTRIDYILIPARFLNRLKDCDIQPEIHGSDHCPVYAEIDFDVVD 319
Query: 356 LKHESFNKPKFEAATRYFLNHGNILDMF 383
+ +K K N+LD F
Sbjct: 320 DGNNILSKRK-----------NNLLDFF 336
>CE16306 [L] KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes
Length = 288
Score = 52.8 bits (125), Expect = 1e-06
Identities = 79/352 (22%), Positives = 136/352 (38%), Gaps = 95/352 (26%)
Query: 2 DEVKDKTGVRFVTFNVNGVRTLFQHYPFSRMNNSLKLAFELFQADIVTLQELKIDAKSIS 61
+E ++ +FV +NV G+R + F + LA E D+V L E K
Sbjct: 26 EEDNNQKSWKFVCWNVAGLRACVKKSDFKEV-----LAEE---PDLVFLGETKCKEWPPE 77
Query: 62 KWGKVEGYQSYITIS-QKRKGYSGVGCWIRTPSEDDPLRHHLKVIKAEEGITGLLRVQAN 120
+ Y + +S +K GY+GVG S+ P++ H
Sbjct: 78 MEETFKNYTKTLVVSTEKNGGYAGVGLL----SKCAPMKVH------------------- 114
Query: 121 GISYRESSEGIGGYTGLDFADENDLLDIDSEGRCIIIELACNVVIFSTYCPANSSQTEEG 180
+GIG + D+ GR II E + Y P + ++
Sbjct: 115 --------KGIGDP------------EFDTAGRLIIAEFS-KFYFIGAYVPNSGAKLVNL 153
Query: 181 ELSRLTFLKLLFKRIRNLHGLGKHVVLMGDINVCRDLKDHATALDESSISLSQQKTGSEI 240
E R + KLL ++++ + K V+ GD+NV + +D + ++ KT
Sbjct: 154 E-KRGRWEKLLTEKMKEMDEK-KPVIYGGDLNVAHN------EIDLKNPESNRNKTAGFT 205
Query: 241 EEK---FNEKCVQFIMDPSRIGRRLLNTMLCDSIISKYAQEGILVDSTRKIQGRDRLKMY 297
+++ F+E +L D+ + + E K Y
Sbjct: 206 DQERGWFSE---------------MLELGFTDTFRAMHPDE----------------KKY 234
Query: 298 TVWNTLLNTRPVNYGSRVDYIFVSKGLKDNITDGDILTTIMGSDHCPVFADI 349
+ W+ L N+R + G R+DY VS + + + DI++++MGSDH PV I
Sbjct: 235 SFWSYLANSRQKDVGWRLDYYVVSNRIMNKVKRSDIMSSVMGSDHAPVVMQI 286
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.136 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,619,619
Number of Sequences: 60738
Number of extensions: 1179822
Number of successful extensions: 2722
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2695
Number of HSP's gapped (non-prelim): 11
length of query: 499
length of database: 30,389,216
effective HSP length: 111
effective length of query: 388
effective length of database: 23,647,298
effective search space: 9175151624
effective search space used: 9175151624
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)