ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV2656 good R KOG3511 General function prediction only Sortilin and related receptors
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV2656 929401 924704 -1566
(1566 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBL017c [R] KOG3511 Sortilin and related receptors 1258 0.0
YJL222w [R] KOG3511 Sortilin and related receptors 1128 0.0
YIL173w [R] KOG3511 Sortilin and related receptors 1128 0.0
YNR065c [R] KOG3511 Sortilin and related receptors 1092 0.0
SPBC16C6.06 [R] KOG3511 Sortilin and related receptors 420 e-116
Hs18379344 [R] KOG3511 Sortilin and related receptors 147 1e-34
Hs4507157_1 [R] KOG3511 Sortilin and related receptors 146 2e-34
Hs17149834 [R] KOG3511 Sortilin and related receptors 139 5e-32
Hs18379342 [R] KOG3511 Sortilin and related receptors 130 2e-29
Hs18379346 [R] KOG3511 Sortilin and related receptors 122 5e-27
YCR100c [R] KOG3511 Sortilin and related receptors 119 5e-26
YCR099c [R] KOG3511 Sortilin and related receptors 112 4e-24
YNR066c [R] KOG3511 Sortilin and related receptors 89 7e-17
>YBL017c [R] KOG3511 Sortilin and related receptors
Length = 1579
Score = 1258 bits (3255), Expect = 0.0
Identities = 687/1591 (43%), Positives = 958/1591 (60%), Gaps = 115/1591 (7%)
Query: 20 AQDFKPKVSFHSDVDTHGRLSILGFDDSRVVLKLLRGVELYRSEDNGVTWDSVGLPLSSD 79
A++F PKV+ D+ IL FDDS +++ + + S D+G TW+ V +
Sbjct: 21 AEEFTPKVTKTIAQDS---FDILSFDDSNTLIRK-QDTSVTISFDDGETWEKV------E 70
Query: 80 NKPQEWNHLVLDRIYKADVAYLSGENG--VLATGDKGKSWKQLTFLDADNHKIDFSDYSN 137
E + +D + D A + NG + T D+GKSW+++T D+ Y
Sbjct: 71 GIEGEITWIYIDPFNRHDRAVATAMNGSYLYITNDQGKSWERITLPDSGESISPRECY-- 128
Query: 138 VGDENRKPIINVEIESHPTNKNARII-------------NIYELGKLDGKFTLRQIS--- 181
IE+HP NKN + N G +G+F + I+
Sbjct: 129 -------------IETHPLNKNYFLAKCNYCEKTEVNNDNEENSGDEEGQFEIFNITRCT 175
Query: 182 ---FYSKDGNNFKLASSGSKSNDDSNPLNMF-CSFVQXXXXXXXXXXXXXVIC---QEST 234
F S DG S ++++P+++ C F + +IC
Sbjct: 176 DKVFASNDGGKSFSEIKSSLERNENSPISISDCGFAKTSKDSDLESSDTSIICLFQNMQL 235
Query: 235 VLSPFGD--VSSKLYITDVNFKSLSPFAEQLQDLSPASTFISDNHLFILTLSDRFNENSA 292
++ F SKL +T KSL F +Q +D I +H+ +LT DR+N+ S+
Sbjct: 236 IMDEFSSPYTESKLVLTTDWGKSLKEF-DQFKDKVVNGYRILKSHMVVLTQGDRYNDMSS 294
Query: 293 ANLWRLEDDSTDKFEQISLGTQIRKSLMD--VNEIDGRAIITIYHXXXXXXXXXXXXXXX 350
++W D S F+ + TQ+R S+ + GR I+ +
Sbjct: 295 MDVWVSNDLSN--FKMAYMPTQLRHSMQGEIYEDAMGRIILPM-------------SRER 339
Query: 351 SPFEDIFSGSIEALISDSYGKNFRHLSFDEQKASS-LTLSTSIFVKKTMFATW------- 402
S E+ E LISDS G F + + + + ++K TM A+
Sbjct: 340 SDQEEDKGIVSEILISDSQGLKFSPIPWTANEVFGYINFYQPTYLKGTMIASLYPLSRRR 399
Query: 403 -----TNTMRDFGFFDFRSKVSFDLGNTWSKLKVSDPEGKWNYNCDINSDSNDCGFQ-MF 456
++ G +K+S D G TW+ LKV DP+ +++CDI +D +C Q MF
Sbjct: 400 NRKGKAKGVKSKGV----TKISVDNGLTWTMLKVVDPDNADSFDCDI-TDFENCSLQNMF 454
Query: 457 IVYGGGVEGDSDIFSPGIIAAIGDVYEENPSGDFLKMGTFISRDDGSTWEKVLDFPSRVV 516
G + + GI+ G V+ D+ TFISRD G TW+ DFP
Sbjct: 455 YTREGSTPTAGILMTTGIVGD-GSVF------DWGDQRTFISRDGGLTWKLAFDFPCLYA 507
Query: 517 MGDYGNIILAVPFDPESDKDPQSEFYFSLDQGKTFQEYQLDKSFYPTELLPSALDGSGNS 576
+GDYGN+I+A+P++ + D DPQSEFY+SLDQGKT+ EYQL+ + YP E++ + DGSG
Sbjct: 508 VGDYGNVIVAIPYNADEDDDPQSEFYYSLDQGKTWTEYQLETTIYPNEVMNTTPDGSGAK 567
Query: 577 FMLVGTIMSEDYQNLESVSYVVDFSDAFKGASCKTSDMEDWYYSNGQCVDGTILKFRRRK 636
F+L G ++ + Y +DFS AF +C+ +D EDW + G+CV+G K RRRK
Sbjct: 568 FILNGFTLAH-MDGTTNFIYAIDFSTAFNDKTCEENDFEDWNLAEGKCVNGVKYKIRRRK 626
Query: 637 QDAQCLIKTTYKDLTFEEELCG-CSELDYECADDFSIDSAGKCVPDFSKASLMEKCES-- 693
QDAQCL+K ++DL E C C+E DYECA +F D+ GKCVPD++ L + C+
Sbjct: 627 QDAQCLVKKVFEDLQLFETACDKCTEADYECAFEFVRDATGKCVPDYNLIVLSDVCDKTK 686
Query: 694 KKSIQLEPKKISKTTKCKRPQNIIKEEISCAAVPAPSN----VKVTENKFSSIFKSYQYF 749
KK++ ++P ++ K KCK+P + +ISC VP + VTENKF + YQYF
Sbjct: 687 KKTVPVKPLQLVKGDKCKKPMTVKSVDISCEGVPKKGTNDKEIVVTENKFDFKIQFYQYF 746
Query: 750 DTFVRESILFRTDKSEAYVSHDGGQNIKQIQTGGEDILEINFNPFFNSSAYLFGKNKNLF 809
DT ES+L + EAY+SHDGGQ IK+ + GE I+E+ FNP++NSSAYLFG ++F
Sbjct: 747 DTVTDESLLMINSRGEAYISHDGGQTIKRFDSNGETIIEVVFNPYYNSSAYLFGSKGSIF 806
Query: 810 ATHDYGLSFKVTELPAGRQLGFPLSFHAKDIQTFIYYGGESCESFFDPNCHAVAYITRDG 869
+THD G SF +LP RQLG PL F+AK TFIYYGG++CES P CHAVAY+T DG
Sbjct: 807 STHDRGYSFMTAKLPEARQLGMPLDFNAKAQDTFIYYGGKNCESILSPECHAVAYLTNDG 866
Query: 870 GASFEKLLEGASNCEFLESAVESPRVENGIVCMVKDKSTGARSYVSSTDYFKT-QTVLYS 928
G +F ++L+ A +CEF S + P E+ ++C VK+KS+ RS VSSTD+F+ + ++
Sbjct: 867 GETFTEMLDNAIHCEFAGSLFKYPSNEDMVMCQVKEKSSQTRSLVSSTDFFQDDKNTVFE 926
Query: 929 DILGFMSTGGYIVVAVSHGERQLRAYLTIDGVEYSEAVLPADLDSYEQKAFTVLGSQEGA 988
+I+G++STGGYI+VAV H +LRAY+TIDG E++EA P D D +Q+AFT+L S++G+
Sbjct: 927 NIIGYLSTGGYIIVAVPHENNELRAYVTIDGTEFAEAKFPYDEDVGKQEAFTILESEKGS 986
Query: 989 IFMHMTTNLDKNEEFGALLKSNTEGTSFVILERAVNRNSFGFVDFEKIQGLEGIILINTV 1048
IF+H+ TNL +FG LLKSN+ GTSFV LE AVNRN+FG+VDFEKIQGLEGIIL N V
Sbjct: 987 IFLHLATNLVPGRDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKIQGLEGIILTNIV 1046
Query: 1049 ANAKEIVESXXXXXXXXXXXXXXFNDGADWTYIKPPSVDSEGKKYNCNPKNLEKCSLNLH 1108
+N+ ++ E+ FN+G+DW ++KPP DSEGKK++C+ K+L++CSL+LH
Sbjct: 1047 SNSDKVAENKEDKQLKTKIT---FNEGSDWNFLKPPKRDSEGKKFSCSSKSLDECSLHLH 1103
Query: 1109 GFTERKDVRDTYSSGSAIGYMFALGNVGEYLTPVSEASTFMTNDGGISWSEVKKGSYQWE 1168
G+TERKD+RDTYSSGSA+G MF +GNVG L P E STF T DGG +W+EVKK +QWE
Sbjct: 1104 GYTERKDIRDTYSSGSALGMMFGVGNVGPNLLPYKECSTFFTTDGGETWAEVKKTPHQWE 1163
Query: 1169 YGDHGSVLVLVKDNEPTDTVSYSINGGKTWKDYQFASEKINVYDLVTVPRDSAMRFLVIG 1228
YGDHG +LVLV +N TD++SYS + GKTWKDY+F ++K+ V D+ TVPRDSA+RFL+ G
Sbjct: 1164 YGDHGGILVLVPENSETDSISYSTDFGKTWKDYKFCADKVLVKDITTVPRDSALRFLLFG 1223
Query: 1229 SSVNVRGEETRTYTLDFVDMFSRQCQY--SKDDLKDFEYISLSHPNTKECLFGHKAKYLR 1286
+ ++ G RTYT+DF ++F RQC + + + D++Y L + CLFGH+ ++LR
Sbjct: 1224 EAADIGGSSFRTYTIDFRNIFERQCDFDITGKESADYKYSPLG--SKSNCLFGHQTEFLR 1281
Query: 1287 KKSDDCYVGMAPLEDKFRIFANCSCTRNDYECDYNFMRVSDGTCKLIDGLKPADPKDICS 1346
K ++C++G PL + R NCSCTR D+ECDYNF + +DGTCKL+ GL PA+ D+C
Sbjct: 1282 KTDENCFIGNIPLSEFSRNIKNCSCTRQDFECDYNFYKANDGTCKLVKGLSPANAADVCK 1341
Query: 1347 KDNSLIEYFEPTGYRKIALSTCNGGLMLANSDSPHPCPGKEKEFKEKYKVNHTSFLAIWI 1406
K+ LIEYFE +GYRKI LSTC GGL L SPH CPGKEKEFKEKY V+ F I+I
Sbjct: 1342 KEPDLIEYFESSGYRKIPLSTCEGGLKLDAPSSPHACPGKEKEFKEKYSVSAGPFAFIFI 1401
Query: 1407 FAVLIFTGMLSFIYYRGIKRNGGFARFGEIRLGDDDLIEENNTDRAVNTVLRNGVFLFSN 1466
+LI F+Y RGI+RNGGFARFGEIRLGDD LIE NNTDR VN ++++G ++FSN
Sbjct: 1402 SILLIIFFAAWFVYDRGIRRNGGFARFGEIRLGDDGLIENNNTDRVVNNIVKSGFYVFSN 1461
Query: 1467 VYTGLQYFGHQVGNFFKRGLSRFGNTTGPSYQSLLHDQFLDDADDLLVGHDEDADDLASF 1526
+ + LQ+ + + + RFGN TGPSY SL+HDQFLD+ADDLL GHDEDA+DL+SF
Sbjct: 1462 IGSLLQHTKTNIAHAISKIRGRFGNRTGPSYSSLIHDQFLDEADDLLAGHDEDANDLSSF 1521
Query: 1527 IENEGNFEIGNDEEVDLSSDTPTHAPYSDNP 1557
++ NFEI EE D+ + H Y+D P
Sbjct: 1522 MDQGSNFEI---EEDDVPTLEEEHTSYTDQP 1549
>YJL222w [R] KOG3511 Sortilin and related receptors
Length = 1549
Score = 1128 bits (2917), Expect = 0.0
Identities = 641/1559 (41%), Positives = 903/1559 (57%), Gaps = 93/1559 (5%)
Query: 20 AQDFKPKVSFHSDVDTHGR--LSILGFDDSRVVLKLLR-GVELYRSEDNGVTWDSVGLPL 76
A++F PKV+ T R I+ FDDS +++ VE+ S D G W ++
Sbjct: 21 AEEFTPKVT-----RTLSRYVFDIVNFDDSNTLIRAEEDSVEI--SFDAGENWKTI---- 69
Query: 77 SSDNKPQEWNHLVLD--RIYKADVAYLSGENGVLATGDKGKSWKQLTFLDADNHKIDFSD 134
D + V+D R + A++ T D+GKSW+ LT ++ F D
Sbjct: 70 --DEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPISEKASNYFCD 127
Query: 135 YSNVGDENRKPIINVEIESHPTNKNARIINI-YELGKLDGKFTLRQI--SFYSKDGNNFK 191
+ + + II ++ T KN+ ++ + E+ + + Q+ SF DG+
Sbjct: 128 VTTHPIKKKHLIIRCDLL---TIKNSGLMYVGREIYTTNDGVSFSQVKPSFGKIDGHIST 184
Query: 192 LASSGSKSNDDSNPLNMFCSFVQXXXXXXXXXXXXXVICQESTVLSPFGDVSSKLYITDV 251
KS++DS+ S + I + +LS G + K +
Sbjct: 185 ARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTGSTIDKSELILSADGGETFKELV--- 241
Query: 252 NFKSLSPFAEQLQDLSPASTFISDNHLFILTLSDRFNENSAANLWRLEDDSTDKFEQISL 311
Q +D + I +H+ +LT D +NE S+ N+W D ST F+
Sbjct: 242 ----------QFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVST--FQVART 289
Query: 312 GTQIRKSLMDVNEID--GRAIITIYHXXXXXXXXXXXXXXXSPFEDIFSGSIEALISDSY 369
T+IR M D GR ++ + G+ E LISDS
Sbjct: 290 PTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQ-------------PGAAEVLISDSE 336
Query: 370 GKNFRHLSF-DEQKASSLTLSTSIFVKKTMFAT------WTNTMRDFGFFDFR--SKVSF 420
G F +++ + + ++ F+K T F + +++ R + R +KVS
Sbjct: 337 GLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSV 396
Query: 421 DLGNTWSKLKVSDPEGKWNYNCDINSDSNDCGFQMFIVYGGGVEGDSDIFSPGIIAAIGD 480
D G TW+ LKV D E + CD+ C Q + + I I G
Sbjct: 397 DNGLTWTNLKVVDRENVDLFGCDVTKPER-CSLQTHFYDLRNLNPSAGIMMISGIVGDGS 455
Query: 481 VYEENPSGDFLKMGTFISRDDGSTWEKVLDFPSRVVMGDYGNIILAVPFDPESDKDPQSE 540
Y ++ + TFISRD G TW V + GD GNII+ +P+ + D S+
Sbjct: 456 AY------NWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIPYRSNENGDVPSK 509
Query: 541 FYFSLDQGKTFQEYQLDKSFYPTELLPSALDGSGNSFMLVGTIMSEDYQNLESVSYVVDF 600
FY+SLDQGKT+ EY L YP L+ + DGSG+ F+L GT ++ED ++Y +DF
Sbjct: 510 FYYSLDQGKTWGEYDLIMPIYPYRLVSTISDGSGSKFILTGTSITEDPI---FITYSIDF 566
Query: 601 SDAFKGASCKTSDMEDWYYSNGQCVDGTILKFRRRKQDAQCLIKTTYKDLTFEEELCG-C 659
S F SC+ D EDW ++G+CV+G K+RRRKQDAQCL+K +KDL+ +E C C
Sbjct: 567 SAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSC 626
Query: 660 SELDYECADDFSIDSAGKCVPDFSKASLMEKCESKK--SIQLEPKKISKTTKCKRPQNII 717
+ DYEC+ +F D+ G C+PD++ +L + C+ K S+ ++P ++ K KCK P I
Sbjct: 627 TGSDYECSFEFVRDAKGDCIPDYNLIALSDICDKSKGKSVLVKPLQLIKGDKCKTPMKIE 686
Query: 718 KEEISCAAVP----APSNVKVTENKFSSIFKSYQYFDTFVRESILFRTDKSEAYVSHDGG 773
+I C +P + + TENKF K YQYFDT ES++ +AY+SHDGG
Sbjct: 687 SVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGG 746
Query: 774 QNIKQIQTGGEDILEINFNPFFNSSAYLFGKNKNLFATHDYGLSFKVTELPAGRQLGFPL 833
Q IK+ T GE I+EI FNP+FNSSAYLFG N+F THD G SF + +LP RQLG PL
Sbjct: 747 QTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPL 806
Query: 834 SFHAKDIQTFIYYGGESCESFFDPNCHAVAYITRDGGASFEKLLEGASNCEFLESAVESP 893
F AK TFIYYGG++CES P CHAVAY+T+DGG +F ++L+ A +CEF + + P
Sbjct: 807 DFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYP 866
Query: 894 RVENGIVCMVKDKSTGARSYVSSTDYFKT-QTVLYSDILGFMSTGGYIVVAVSHGERQLR 952
++ ++C VK+K + RS VSSTD+F+ + ++ +I+G++STGGYI+VAV H + +LR
Sbjct: 867 SNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELR 926
Query: 953 AYLTIDGVEYSEAVLPADLDSYEQKAFTVLGSQEGAIFMHMTTNLDKNEEFGALLKSNTE 1012
AY+T DG E++EA P D D +Q AFT+LGS+EG+IF+H+ TNL+ +FG LLKSN+
Sbjct: 927 AYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSN 986
Query: 1013 GTSFVILERAVNRNSFGFVDFEKIQGLEGIILINTVANAKEIVESXXXXXXXXXXXXXXF 1072
GTSFV LE AVNRN+FG+VDFEK+QGLEGII+ N V+N++++ E+ F
Sbjct: 987 GTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKIT---F 1043
Query: 1073 NDGADWTYIKPPSVDSEGKKYNCNPKNLEKCSLNLHGFTERKDVRDTYSSGSAIGYMFAL 1132
NDG+DW ++KPP DSEGKK+ C+ +L+KCSL+LHG+TERKD+RDTYSSGSA+G MF +
Sbjct: 1044 NDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGV 1103
Query: 1133 GNVGEYLTPVSEASTFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLVKDNEPTDTVSYSI 1192
GNVG+ L P E STF+T DGG +W+EVKKG +QWEYGDHG VLVLV +N TD++SYS
Sbjct: 1104 GNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYST 1163
Query: 1193 NGGKTWKDYQFASEKINVYDLVTVPRDSAMRFLVIGSSVNVRGEETRTYTLDFVDMFSRQ 1252
+ GKTWKDY+F +K+ V D++TVPRDSA+RFL+ G + N+ RTYT+DF ++F RQ
Sbjct: 1164 DFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQ 1223
Query: 1253 CQYSKDDLK--DFEYISLSHPNTKECLFGHKAKYLRKKSDDCYVGMAPLEDKFRIFANCS 1310
C++ K DF+Y L + CLFGHK ++LRK + C++G PL + R NC
Sbjct: 1224 CEFDITGRKRADFKYSPLG--SRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCP 1281
Query: 1311 CTRNDYECDYNFMRVSDGTCKLIDGLKPADPKDICSKDNSLIEYFEPTGYRKIALSTCNG 1370
CTR D+ECDYNF + SDGTCKL+ GL A+ DIC K+ LIEY++ +GYRKI LSTC G
Sbjct: 1282 CTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKG 1341
Query: 1371 GLMLANSDSPHPCPGKEKEFKEKYKVNHTSFLAIWIFAVLIFTGMLSFIYYRGIKRNGGF 1430
GL L +PHPCPGKEK F+EKY +N ++ +++ +L+ + F+Y RGI+RNGGF
Sbjct: 1342 GLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGF 1401
Query: 1431 ARFGEIRLGDDDLIEENNTDRAVNTVLRNGVFLFSNVYTGLQYFGHQVGNFFKRGLSRFG 1490
+RF EIRLGDD LIE N TDR VN ++R G+ + + Q + +RFG
Sbjct: 1402 SRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRAKAGTAQLSSKFRARFG 1461
Query: 1491 NTTGPSYQSLLHDQFLDDADDLLVGHDEDADDLASFIENEGNFEIGNDEEVDLSSDTPT 1549
N G +Y SLLHDQ D+ D G ED++DL+SF N EI E+VD S T
Sbjct: 1462 NKKGATYSSLLHDQLSDEPD----GFHEDSNDLSSFRGQGSNSEI-EQEDVDTSQQEHT 1515
>YIL173w [R] KOG3511 Sortilin and related receptors
Length = 1549
Score = 1128 bits (2917), Expect = 0.0
Identities = 641/1559 (41%), Positives = 903/1559 (57%), Gaps = 93/1559 (5%)
Query: 20 AQDFKPKVSFHSDVDTHGR--LSILGFDDSRVVLKLLR-GVELYRSEDNGVTWDSVGLPL 76
A++F PKV+ T R I+ FDDS +++ VE+ S D G W ++
Sbjct: 21 AEEFTPKVT-----RTLSRYVFDIVNFDDSNTLIRAEEDSVEI--SFDAGENWKTI---- 69
Query: 77 SSDNKPQEWNHLVLD--RIYKADVAYLSGENGVLATGDKGKSWKQLTFLDADNHKIDFSD 134
D + V+D R + A++ T D+GKSW+ LT ++ F D
Sbjct: 70 --DEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPISEKASNYFCD 127
Query: 135 YSNVGDENRKPIINVEIESHPTNKNARIINI-YELGKLDGKFTLRQI--SFYSKDGNNFK 191
+ + + II ++ T KN+ ++ + E+ + + Q+ SF DG+
Sbjct: 128 VTTHPIKKKHLIIRCDLL---TIKNSGLMYVGREIYTTNDGVSFSQVKPSFGKIDGHIST 184
Query: 192 LASSGSKSNDDSNPLNMFCSFVQXXXXXXXXXXXXXVICQESTVLSPFGDVSSKLYITDV 251
KS++DS+ S + I + +LS G + K +
Sbjct: 185 ARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTGSTIDKSELILSADGGETFKELV--- 241
Query: 252 NFKSLSPFAEQLQDLSPASTFISDNHLFILTLSDRFNENSAANLWRLEDDSTDKFEQISL 311
Q +D + I +H+ +LT D +NE S+ N+W D ST F+
Sbjct: 242 ----------QFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVST--FQVART 289
Query: 312 GTQIRKSLMDVNEID--GRAIITIYHXXXXXXXXXXXXXXXSPFEDIFSGSIEALISDSY 369
T+IR M D GR ++ + G+ E LISDS
Sbjct: 290 PTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQ-------------PGAAEVLISDSE 336
Query: 370 GKNFRHLSF-DEQKASSLTLSTSIFVKKTMFAT------WTNTMRDFGFFDFR--SKVSF 420
G F +++ + + ++ F+K T F + +++ R + R +KVS
Sbjct: 337 GLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSV 396
Query: 421 DLGNTWSKLKVSDPEGKWNYNCDINSDSNDCGFQMFIVYGGGVEGDSDIFSPGIIAAIGD 480
D G TW+ LKV D E + CD+ C Q + + I I G
Sbjct: 397 DNGLTWTNLKVVDRENVDLFGCDVTKPER-CSLQTHFYDLRNLNPSAGIMMISGIVGDGS 455
Query: 481 VYEENPSGDFLKMGTFISRDDGSTWEKVLDFPSRVVMGDYGNIILAVPFDPESDKDPQSE 540
Y ++ + TFISRD G TW V + GD GNII+ +P+ + D S+
Sbjct: 456 AY------NWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIPYRSNENGDVPSK 509
Query: 541 FYFSLDQGKTFQEYQLDKSFYPTELLPSALDGSGNSFMLVGTIMSEDYQNLESVSYVVDF 600
FY+SLDQGKT+ EY L YP L+ + DGSG+ F+L GT ++ED ++Y +DF
Sbjct: 510 FYYSLDQGKTWGEYDLIMPIYPYRLVSTISDGSGSKFILTGTSITEDPI---FITYSIDF 566
Query: 601 SDAFKGASCKTSDMEDWYYSNGQCVDGTILKFRRRKQDAQCLIKTTYKDLTFEEELCG-C 659
S F SC+ D EDW ++G+CV+G K+RRRKQDAQCL+K +KDL+ +E C C
Sbjct: 567 SAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSC 626
Query: 660 SELDYECADDFSIDSAGKCVPDFSKASLMEKCESKK--SIQLEPKKISKTTKCKRPQNII 717
+ DYEC+ +F D+ G C+PD++ +L + C+ K S+ ++P ++ K KCK P I
Sbjct: 627 TGSDYECSFEFVRDAKGDCIPDYNLIALSDICDKSKGKSVLVKPLQLIKGDKCKTPMKIE 686
Query: 718 KEEISCAAVP----APSNVKVTENKFSSIFKSYQYFDTFVRESILFRTDKSEAYVSHDGG 773
+I C +P + + TENKF K YQYFDT ES++ +AY+SHDGG
Sbjct: 687 SVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGG 746
Query: 774 QNIKQIQTGGEDILEINFNPFFNSSAYLFGKNKNLFATHDYGLSFKVTELPAGRQLGFPL 833
Q IK+ T GE I+EI FNP+FNSSAYLFG N+F THD G SF + +LP RQLG PL
Sbjct: 747 QTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPL 806
Query: 834 SFHAKDIQTFIYYGGESCESFFDPNCHAVAYITRDGGASFEKLLEGASNCEFLESAVESP 893
F AK TFIYYGG++CES P CHAVAY+T+DGG +F ++L+ A +CEF + + P
Sbjct: 807 DFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYP 866
Query: 894 RVENGIVCMVKDKSTGARSYVSSTDYFKT-QTVLYSDILGFMSTGGYIVVAVSHGERQLR 952
++ ++C VK+K + RS VSSTD+F+ + ++ +I+G++STGGYI+VAV H + +LR
Sbjct: 867 SNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELR 926
Query: 953 AYLTIDGVEYSEAVLPADLDSYEQKAFTVLGSQEGAIFMHMTTNLDKNEEFGALLKSNTE 1012
AY+T DG E++EA P D D +Q AFT+LGS+EG+IF+H+ TNL+ +FG LLKSN+
Sbjct: 927 AYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSN 986
Query: 1013 GTSFVILERAVNRNSFGFVDFEKIQGLEGIILINTVANAKEIVESXXXXXXXXXXXXXXF 1072
GTSFV LE AVNRN+FG+VDFEK+QGLEGII+ N V+N++++ E+ F
Sbjct: 987 GTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKIT---F 1043
Query: 1073 NDGADWTYIKPPSVDSEGKKYNCNPKNLEKCSLNLHGFTERKDVRDTYSSGSAIGYMFAL 1132
NDG+DW ++KPP DSEGKK+ C+ +L+KCSL+LHG+TERKD+RDTYSSGSA+G MF +
Sbjct: 1044 NDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGV 1103
Query: 1133 GNVGEYLTPVSEASTFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLVKDNEPTDTVSYSI 1192
GNVG+ L P E STF+T DGG +W+EVKKG +QWEYGDHG VLVLV +N TD++SYS
Sbjct: 1104 GNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYST 1163
Query: 1193 NGGKTWKDYQFASEKINVYDLVTVPRDSAMRFLVIGSSVNVRGEETRTYTLDFVDMFSRQ 1252
+ GKTWKDY+F +K+ V D++TVPRDSA+RFL+ G + N+ RTYT+DF ++F RQ
Sbjct: 1164 DFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQ 1223
Query: 1253 CQYSKDDLK--DFEYISLSHPNTKECLFGHKAKYLRKKSDDCYVGMAPLEDKFRIFANCS 1310
C++ K DF+Y L + CLFGHK ++LRK + C++G PL + R NC
Sbjct: 1224 CEFDITGRKRADFKYSPLG--SRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCP 1281
Query: 1311 CTRNDYECDYNFMRVSDGTCKLIDGLKPADPKDICSKDNSLIEYFEPTGYRKIALSTCNG 1370
CTR D+ECDYNF + SDGTCKL+ GL A+ DIC K+ LIEY++ +GYRKI LSTC G
Sbjct: 1282 CTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKG 1341
Query: 1371 GLMLANSDSPHPCPGKEKEFKEKYKVNHTSFLAIWIFAVLIFTGMLSFIYYRGIKRNGGF 1430
GL L +PHPCPGKEK F+EKY +N ++ +++ +L+ + F+Y RGI+RNGGF
Sbjct: 1342 GLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGF 1401
Query: 1431 ARFGEIRLGDDDLIEENNTDRAVNTVLRNGVFLFSNVYTGLQYFGHQVGNFFKRGLSRFG 1490
+RF EIRLGDD LIE N TDR VN ++R G+ + + Q + +RFG
Sbjct: 1402 SRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRAKAGTAQLSSKFRARFG 1461
Query: 1491 NTTGPSYQSLLHDQFLDDADDLLVGHDEDADDLASFIENEGNFEIGNDEEVDLSSDTPT 1549
N G +Y SLLHDQ D+ D G ED++DL+SF N EI E+VD S T
Sbjct: 1462 NKKGATYSSLLHDQLSDEPD----GFHEDSNDLSSFRGQGSNSEI-EQEDVDTSQQEHT 1515
>YNR065c [R] KOG3511 Sortilin and related receptors
Length = 1116
Score = 1092 bits (2823), Expect = 0.0
Identities = 540/1091 (49%), Positives = 728/1091 (66%), Gaps = 30/1091 (2%)
Query: 489 DFLKMGTFISRDDGSTWEKVLDFPSRVVMGDYGNIILAVPFDPESDKDPQSEFYFSLDQG 548
D+ TFISRD G TW V + GD GNII+ +P+DPE D D QSEFY+SLDQG
Sbjct: 14 DWEDQKTFISRDGGLTWRFVHNSSGLYATGDLGNIIVYIPYDPEEDGDFQSEFYYSLDQG 73
Query: 549 KTFQEYQLDK---SFYPTELLPSALDGSGNSFMLVGTIMSEDYQ-----NLESVSYVVDF 600
+T+ EY+L S +P +L+ DGSG+ F+ GT + D + +L+ V Y++DF
Sbjct: 74 RTWNEYELTNAISSVHPYKLINPTPDGSGSKFIFKGTFATTDSETNSITSLKGVEYIIDF 133
Query: 601 SDAFKGASCKTSDMEDWYYSNGQCVDGTILKFRRRKQDAQCLIKTTYKDLTFEEELCG-C 659
S AF +C+ D EDW ++G+CV+G K+RRRKQDAQCL+K +KDL+ +E C C
Sbjct: 134 SAAFDSRTCEEEDFEDWDLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSC 193
Query: 660 SELDYECADDFSIDSAGKCVPDFSKASLMEKCESKK--SIQLEPKKISKTTKCKRPQNII 717
E DYEC+ +F D+ G C+PD++ + C+ K S+ +EP ++ K +CK P I
Sbjct: 194 GESDYECSFEFVRDANGLCIPDYNLIAFSNICDKSKDKSVLVEPLQLIKGDECKTPMKIE 253
Query: 718 KEEISCAAVPAPSN----VKVTENKFSSIFKSYQYFDTFVRESILFRTDKSEAYVSHDGG 773
+I C +P + + TENKF K YQYFDT ES++ +AY+SHDGG
Sbjct: 254 PVDIPCDEIPEEGSSDREIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGG 313
Query: 774 QNIKQIQTGGEDILEINFNPFFNSSAYLFGKNKNLFATHDYGLSFKVTELPAGRQLGFPL 833
Q IK+ T GE I+E+ FNP+FNSSAYLFG N+F+THD G SF + +LP RQLG PL
Sbjct: 314 QTIKRFDTNGEKIVEVVFNPYFNSSAYLFGSKGNIFSTHDRGHSFMIAKLPEARQLGMPL 373
Query: 834 SFHAKDIQTFIYYGGESCESFFDPNCHAVAYITRDGGASFEKLLEGASNCEFLESAVESP 893
F AK TFIYYGG++CES P CHAVAY+T+DGG +F ++L+ A +CEF + E P
Sbjct: 374 DFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFEYP 433
Query: 894 RVENGIVCMVKDKSTGARSYVSSTDYFKTQT-VLYSDILGFMSTGGYIVVAVSHGERQLR 952
E ++C VK KS+ RS VSS D+F+ +++ +I+G++STGGYI+VAV H + +LR
Sbjct: 434 SNEEMVMCQVKKKSSETRSLVSSIDFFQGDNKIIFENIIGYLSTGGYIIVAVPHEDNELR 493
Query: 953 AYLTIDGVEYSEAVLPADLDSYEQKAFTVLGSQEGAIFMHMTTNLDKNEEFGALLKSNTE 1012
AY+TIDG E++EA P D +Q+AFT+LGS++G+IF+H+ TNL+ +FG LLKSN+
Sbjct: 494 AYVTIDGTEFAEAKFPYGQDVSKQEAFTILGSEKGSIFLHLATNLESGHDFGNLLKSNSN 553
Query: 1013 GTSFVILERAVNRNSFGFVDFEKIQGLEGIILINTVANAKEIVESXXXXXXXXXXXXXXF 1072
GTSFV LE AVNRN+FG+VDFEK+QGLEGII+ N V+N +++ E+ F
Sbjct: 554 GTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNREKVGENKEDEQLKTKIT---F 610
Query: 1073 NDGADWTYIKPPSVDSEGKKYNCNPKNLEKCSLNLHGFTERKDVRDTYSSGSAIGYMFAL 1132
NDG+DW ++KPP DSEGKK+ C+ +L+KCSL+LHG+TERKD+RDTYSSGSA+G MF +
Sbjct: 611 NDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGV 670
Query: 1133 GNVGEYLTPVSEASTFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLVKDNEPTDTVSYSI 1192
GNVG+ L P E STF+T DGG +W+EVKKG +QWEYGDHG VLVLV +N TD++SYS
Sbjct: 671 GNVGDKLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYST 730
Query: 1193 NGGKTWKDYQFASEKINVYDLVTVPRDSAMRFLVIGSSVNVRGEETRTYTLDFVDMFSRQ 1252
+ GKTWKDY+F +K+ V D++TVPRDSA+RFL+ G + N+ RTYT+DF ++F RQ
Sbjct: 731 DFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQ 790
Query: 1253 CQYSKDDLK--DFEYISLSHPNTKECLFGHKAKYLRKKSDDCYVGMAPLEDKFRIFANCS 1310
C++ K DF+Y L + CLFGH+ ++LRK + C++G PL + R NCS
Sbjct: 791 CEFDITGKKRADFKYSPLG--SRTGCLFGHQTEFLRKTDEKCFIGNIPLSEFSRNVKNCS 848
Query: 1311 CTRNDYECDYNFMRVSDGTCKLIDGLKPADPKDICSKDNSLIEYFEPTGYRKIALSTCNG 1370
CTR D+ECDYNF + SDGTCKL+ GL A+ DIC K+ LIEY++ +GYRKI LSTC G
Sbjct: 849 CTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKG 908
Query: 1371 GLMLANSDSPHPCPGKEKEFKEKYKVNHTSFLAIWIFAVLIFTGMLSFIYYRGIKRNGGF 1430
GL L +PHPCPGKEK F+EKY +N ++ +++ +L+ F+Y RGI+RNGGF
Sbjct: 909 GLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFAAWFVYDRGIRRNGGF 968
Query: 1431 ARFGEIRLGDDDLIEENNTDRAVNTVLRNGVFLFSNVYTGLQYFGHQVGNFFKRGLSRFG 1490
+RF EIRLGDD LIE N TDR VN ++R G+ + + Q V F + +RFG
Sbjct: 969 SRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRTKAGVARFSSKLRARFG 1028
Query: 1491 NTTGPSYQSLLHDQFLDDADDLLVGHDEDADDLASFIENEGNFEIGNDEEVDLSSDTPTH 1550
N GP+Y SLL QF D++D G EDA+DL+SF + NFEI E+ D H
Sbjct: 1029 NRKGPTYSSLLQGQFSDESD----GLHEDANDLSSFTSQDSNFEI---EQEDAYRPEQEH 1081
Query: 1551 APYSDNPEEAN 1561
D P +N
Sbjct: 1082 TSQIDQPATSN 1092
>SPBC16C6.06 [R] KOG3511 Sortilin and related receptors
Length = 1466
Score = 420 bits (1079), Expect = e-116
Identities = 305/1064 (28%), Positives = 515/1064 (47%), Gaps = 79/1064 (7%)
Query: 416 SKVSFDLGNTWSKLKVSDPEGKWNYNCDINSDSNDCGFQMFI-VYGGGVEGDSDIFSPGI 474
S+++FD G TWS V+ PE N C +F+ + S F+PGI
Sbjct: 387 SRITFDGGKTWST--VASPESSCN-------SMKQCSLHLFLDPHVSHASIASSKFAPGI 437
Query: 475 IAAIGDVYEENPSGDFLKMGTFISRDDGSTWEKVLDFPSRVVMGDYGNIILAVPFDPESD 534
+ A G V + S + +M F+S D G W D M +G+I A +
Sbjct: 438 LLASGSVGDRLLSEN--QMDLFVSEDGGRNWTLSRDGMHLFAMSGFGSIFFASEY----- 490
Query: 535 KDPQSEFYFSLDQGKTFQEYQLDKSFYPTELLPSALDGSGNSFMLVGTIMSEDYQNLESV 594
D +E Y+SLD G+++ LDK+ P +L S D F L+ + N
Sbjct: 491 LDVINEVYYSLDHGQSWVTVTLDKTIVPIKLFASE-DPYAEIFYLLAMTDDGEQSNYSLF 549
Query: 595 SY----VVDFSDAFKGASCKTSDMEDWY--YSNGQCVDGTILK---FRRRKQDAQCLIKT 645
S+ + F + +D E WY Y+NG + + K F R+K + C +
Sbjct: 550 SFNFGKFLPKECQFSNSESNKNDFEKWYTRYANGSPICSEMGKKEFFWRKKATSVCSVPK 609
Query: 646 TYKDLTFEEELCGCSELDYECADDFSIDSAGKC-VPDFSKASLMEKCESKKSIQLEPKKI 704
+ DL + C C++ DYEC F + G+C + DF SL+ E + Q P ++
Sbjct: 610 SITDLHGSFDACECTDEDYECNTQFISNDQGECKLLDFI-GSLLCASEDLDTFQKIPYRL 668
Query: 705 SKTTKC---KRPQNIIKEEISCAAVPAPSNVKVTE--NKFSSIFKSYQYFDTFVRESILF 759
KC KR + + +C + P ++T F Y + V E F
Sbjct: 669 VPGNKCTPNKRDSHREPQTFNCDSFNEPGT-EITSFLYDFDEKIVDVVYLEGTVPEENTF 727
Query: 760 RTD---KSEAYVSHDGGQNIKQIQTGGEDILEINFNPFFNSSAYLFGKNKNLFATHDYGL 816
S Y S D G+ + E+ + + + +S Y+ ++ T + G
Sbjct: 728 LIGISVNSHVYFSEDEGKTWDKFSK--EEFSSVLPHAYNKNSVYMVTSKNIVYFTTNRGK 785
Query: 817 SFKVTELPAG-RQLGFPL-SFHAKDIQTFIYYGGESCESF-FDPNCHAVAYITRDGGASF 873
+F + P+ Q G L SFH +Y G E+CE F +C V +++ D G ++
Sbjct: 786 NFYKFKAPSPPNQNGKSLFSFHPSRPAWLLYAGSENCEKNPFADDCRDVVFVSLDFGDTW 845
Query: 874 EKLLEGASNCEFLESAVESPRVENGIVCMVKDKSTGA--RSYVSSTDYFK-TQTVLYSDI 930
+L C + ++ E V++ ++ ++ + + +SS D+F+ Q + +D+
Sbjct: 846 SRLPSNLEYCSWAKA--EKLVVDDTLIFCIRQNTNDPFKKELISSIDFFEYEQDEILNDV 903
Query: 931 LGFMSTGGYIVVAVSHGE-RQLRAYLTIDGVEYSEAVLPADLDSYEQKAFTVLGSQEGAI 989
+GFM Y++VAV E L ++I+G+ ++ PA L+ + ++A+T+L SQ ++
Sbjct: 904 VGFMIEDEYVIVAVQDEEGTSLSLDVSINGLNFASCSFPAYLNVHPKQAYTILDSQTHSL 963
Query: 990 FMHMTTNLDKNEEFGALLKSNTEGTSFVILERAVNRNSFGFVDFEKIQGLEGIILINTVA 1049
F+H+TTN E+G +LKSN+ GT F+ VNR+S G+VDFE+++G++GI L N V+
Sbjct: 964 FIHVTTNTHLGSEWGDILKSNSNGTYFMTSLANVNRDSVGYVDFERLEGIQGIALANIVS 1023
Query: 1050 NAKEIVESXXXXXXXXXXXXXXFNDGADWTYIKPPSVDSEGKKYNCNPKNLEKCSLNLHG 1109
N KE+ + FNDG DW+Y+ G+K PK + C L+LHG
Sbjct: 1024 NTKELTDGGTKKLQTLIT----FNDGLDWSYLNLVG----GEKIV--PKCGKNCYLHLHG 1073
Query: 1110 FTERKDVRDTYSSGSAIGYMFALGNVGEYLTPVSEASTFMTNDGGISWSEVKKGSYQWEY 1169
+TER D S+ +A+G + +G+ +L P E+ TF++ D G++W + + W +
Sbjct: 1074 YTERNQFSDPTSTNAAVGLIIGVGSFSPFLIPYEESQTFISRDAGVTWYRIFDSPHLWAF 1133
Query: 1170 GDHGSVLVLVKDNEPTDTVSYSINGGKTWKDYQFASEKINVYDLVTVPRDSAMRFLVIGS 1229
D GS+++ V+ PT+ + YS + G+TW++YQF+ + V D+ T P + L++
Sbjct: 1134 LDSGSIIIAVESISPTNVIKYSADEGRTWQEYQFSEKSKVVVDVSTKPSGVGHQVLLL-- 1191
Query: 1230 SVNVRGEETRTYTLDFVDMFSRQCQYSKDDLKDFEYISLSHPNTKE---CLFGHKAKYLR 1286
+ + + +DF ++ R C + +++ ++ +++ + CL G + + R
Sbjct: 1192 TTDDENAPISSVLIDFDALYRRTCVFDEENSEESDFVRWVPTDISGKPLCLRGRISSFYR 1251
Query: 1287 KK-SDDCYVGMAPLEDKFRIFANCSCTRNDYECDYNFMRVSDGTCKLIDGLKPADPK-DI 1344
K C VG + L K + + C CTR D+ECDYN+ R+ DGTC L+ GL+P D + +
Sbjct: 1252 KSIHKKCRVGSSLLV-KEEVLSKCECTRADFECDYNYRRLKDGTCVLVSGLQPPDTREEQ 1310
Query: 1345 CSKDNSLIEYFEPTGYRKIALSTCNGGLMLANSDSPHPCPGKEKE-FKEKYKVNHTSFLA 1403
CS D++ E+ +PTGY++ L+ C GG+ L ++ + HPCPGKE + +K K S
Sbjct: 1311 CSVDDA-FEWRQPTGYKRTPLTECEGGVPL-DAGTLHPCPGKEDDYYKAHPKPGGWSIFL 1368
Query: 1404 IWIFAVLI--FTGMLSFIYYRGIKRNGGFARFGEIRLGDDDLIE 1445
IF++L+ G + + Y R + G IRLG D E
Sbjct: 1369 TIIFSILLAAVAGCILYYYSRRFLK-------GAIRLGSDSATE 1405
Score = 157 bits (397), Expect = 1e-37
Identities = 165/673 (24%), Positives = 292/673 (42%), Gaps = 56/673 (8%)
Query: 723 CAAVPAPSNVKVTENKFSSIFKSYQYFDTFVRESILFRTDKSEAYVSHDGGQNIKQIQTG 782
C A PA +V E F S + F ++ + + Y+S D GQ+ +
Sbjct: 31 CIASPA---AEVAETVFDSKPVDFMTFKDSTN-TLFLNAEFGDVYLSQDNGQSWRNGVIS 86
Query: 783 GE--DILEINFNPFFNSSAYLFGKNKNLFATHDYGLS---FKVTELPAGRQLGFPLSFHA 837
G+ I ++ + F NS + + ++ ++D G + F + + QL P FHA
Sbjct: 87 GQVCPIKKLIKHSFENSRVFALTECDTVYYSYDNGENWDYFTIDHPISITQL--PFHFHA 144
Query: 838 KDIQTFIYYGGESCES---FFDPNCHAVAYITRDGGASF-EKLLEGASNCEFLESAVESP 893
K+ ++ + + C S + C Y T+DG S E + G+S C F +S+ +
Sbjct: 145 KN-PDYVIFNNQYCSSSGTWVGKICKPDLYYTKDGFQSDPEPMPVGSSYCIFADSSEKMV 203
Query: 894 -RVENGIVCMVKDKSTGARS-----YVSSTDYFKT------QTVLYSD-ILGFMSTGGYI 940
E I+C+ + ++ AR V S D+F++ L SD G +STG ++
Sbjct: 204 VSSEEQIICISLNPNSAARPPFSHHIVYSDDWFQSIVPVQLHNFLGSDGAYGILSTGSFL 263
Query: 941 VVA-VSHGERQLRAYLTIDGVEYSEAVLPADLDSYEQKAFTVLGSQEGAIFMHMTTNLDK 999
V A + R+L Y++ DG + EA+ +E AFT+L S E + F+ + +
Sbjct: 264 VAALIDAATRKLFVYVSQDGYYWEEAL--KFHKGFEFDAFTILPSTEYSFFID-SLDSHP 320
Query: 1000 NEEFGALLKSNTEGTSFVILERAVNRNSFGFVDFEKIQGLEGIILINTVANAKEIVESXX 1059
N G L ++E +FVI + NR G+ DF I L+G+ +N V N EI
Sbjct: 321 NNPTGILYSLDSESNTFVIRQMNTNRYVDGYTDFMLIDYLDGLQFVNVVENVDEI--EVD 378
Query: 1060 XXXXXXXXXXXXFNDGADWTYIKPPSVDSEGKKYNCNPKNLEKCSLNLHGFTERKDVRDT 1119
F+ G W+ + P + +CN ++++CSL+L
Sbjct: 379 PQVDKVLSSRITFDGGKTWSTVASP-------ESSCN--SMKQCSLHLF-LDPHVSHASI 428
Query: 1120 YSSGSAIGYMFALGNVGEYLTPVSEASTFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLV 1179
SS A G + A G+VG+ L ++ F++ DGG +W+ + G + + GS+
Sbjct: 429 ASSKFAPGILLASGSVGDRLLSENQMDLFVSEDGGRNWTLSRDGMHLFAMSGFGSIFFAS 488
Query: 1180 KDNEPTDTVSYSINGGKTWKDYQFASEKINVYDLVTVPRDSAMRFLVIGSSVNVRGEETR 1239
+ + + V YS++ G++W + I L A F ++ + +
Sbjct: 489 EYLDVINEVYYSLDHGQSWVTVTL-DKTIVPIKLFASEDPYAEIFYLLAMTDDGEQSNYS 547
Query: 1240 TYTLDFVDMFSRQCQY--SKDDLKDFE--YISLSHPNTKECLFGHKAKYLRKKSDDCYVG 1295
++ +F ++CQ+ S+ + DFE Y ++ + G K + RKK+
Sbjct: 548 LFSFNFGKFLPKECQFSNSESNKNDFEKWYTRYANGSPICSEMGKKEFFWRKKATSVCSV 607
Query: 1296 MAPLEDKFRIFANCSCTRNDYECDYNFMRVSDGTCKLIDGLKPADPKDICSKDNSLIEYF 1355
+ D F C CT DYEC+ F+ G CKL+D + +C+ ++ ++ F
Sbjct: 608 PKSITDLHGSFDACECTDEDYECNTQFISNDQGECKLLDFIGSL----LCASED--LDTF 661
Query: 1356 EPTGYRKIALSTC 1368
+ YR + + C
Sbjct: 662 QKIPYRLVPGNKC 674
>Hs18379344 [R] KOG3511 Sortilin and related receptors
Length = 1009
Score = 147 bits (372), Expect = 1e-34
Identities = 146/611 (23%), Positives = 254/611 (40%), Gaps = 79/611 (12%)
Query: 798 SAYLFGKNKNLFATHDYGLSFKVTELPAGRQLGFPLSFHAKDIQTFIYYGGESCESFFDP 857
S+ L ++++LF + D G +F+ +P + L FH K+ + Y ES
Sbjct: 71 SSSLSDRDQSLFLSADEGATFQKQPIPFFVET---LIFHPKEEDKVLAYTKES------- 120
Query: 858 NCHAVAYITRDGGASFEKLLEGASNCEFLESAVESPRVENGIVCMVKDKSTGARSYVSST 917
Y++ D G + L E + S V + +V + G YV+
Sbjct: 121 ----KLYVSSDLGKKWTLLQERVTKDHVFWS-VSGVDADPDLVHVEAQDLGGDFRYVTCA 175
Query: 918 DYFKTQTVLYSDILGFMSTGGYIV-----VAVSHGERQLRAYLTIDGVEYSEAVLPADLD 972
+ ++ +L + G + G V + Q + Y++ E+ LP
Sbjct: 176 IHNCSEKMLTAPFAGPIDHGSLTVQDDYIFFKATSANQTKYYVSYRRNEFVLMKLP---- 231
Query: 973 SYE-QKAFTVLGSQEGAIFMHMTTNLDKNEEFGALLKSNTEGTSFVILERAVNRNSFG-- 1029
Y K ++ + E +F+ + + L +S+ G + ++ + V +
Sbjct: 232 KYALPKDLQIISTDESQVFVAVQEWYQMDTY--NLYQSDPRGVRYALVLQDVRSSRQAEE 289
Query: 1030 --FVDFEKIQGLEGIILINTVANAKEIVESXXXXXXXXXXXXXXFNDGADWTYIKPPSVD 1087
+D +++G++G+ L N + K + +N G DW Y++PPS+D
Sbjct: 290 SVLIDILEVRGVKGVFLANQKIDGKVMT-------------LITYNKGRDWDYLRPPSMD 336
Query: 1088 SEGKKYNCNPKNLEKCSLNLH-GFTERKDVRDT-YSSGSAIGYMFALGNVGEYLTPVSEA 1145
GK NC P + C L+LH + + V T ++ +A G + GN+G L E
Sbjct: 337 MNGKPTNCKPPD---CHLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKE- 392
Query: 1146 STFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLVKDNE-PTDTVSYSINGGKTWKDYQFA 1204
++T+D G +W +V + + Y DHG V+V +KD P + +S++ G TW + F
Sbjct: 393 EMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFT 452
Query: 1205 SEKINVYDLVTVPRDSAMRFLVIGSSVNVRGEETRTYTLDFVDMFSRQCQYSKDDLKDFE 1264
S + V L++ P D + V G ++ R + +DF FSRQC ++D +E
Sbjct: 453 STSVFVDGLLSEPGDETLVMTVFG-HISFR-SDWELVKVDFRPSFSRQC--GEEDYSSWE 508
Query: 1265 YISLSHPNTKECLFGHKAKYLRKKSDDCYVGMAPLEDKFRIFAN------CSCTRNDYEC 1318
LS+ C+ G + + ++KS + K R F + C C +D+ C
Sbjct: 509 ---LSNLQGDRCIMGQQRSFRKRKSTSWCI-------KGRSFTSALTSRVCECRDSDFLC 558
Query: 1319 DYNFMRVSD-----GTCKLIDGLKPADPKDICSKDNSLIEYFEPTGYRKIALSTCNGGLM 1373
DY F R S C P P D C+ + Y GYRK+ + C GG+
Sbjct: 559 DYGFERSSSSESSTNKCSANFWFNPLSPPDDCALGQT---YTSSLGYRKVVSNVCEGGVD 615
Query: 1374 LANSDSPHPCP 1384
+ S CP
Sbjct: 616 MQQSQVQLQCP 626
Score = 62.8 bits (151), Expect = 4e-09
Identities = 66/280 (23%), Positives = 108/280 (38%), Gaps = 34/280 (12%)
Query: 418 VSFDLGNTWSKLKVS--DPEGKWNYNCDINSDSNDCGFQMFI-----VYGGGVEGDSDIF 470
++++ G W L+ D GK N DC + + Y G D
Sbjct: 319 ITYNKGRDWDYLRPPSMDMNGK-----PTNCKPPDCHLHLHLRWADNPYVSGTVHTKDT- 372
Query: 471 SPGIIAAIGDVYEENPSGDFLKMGTFISRDDGSTWEKVLDFPSRVVMGDYGNIILAVPFD 530
+PG+I G++ + K +I+ D G TW +V + ++ D+G +I+A+
Sbjct: 373 APGLIMGAGNLGSQLVE---YKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAI--- 426
Query: 531 PESDKDPQSEFYFSLDQGKTFQEYQLDKSFYPTELLPSALDGSGNSFMLVGTIMSEDYQN 590
+ P FS+D+G T+ + +F T + L LV T+
Sbjct: 427 -KDTSIPLKILKFSVDEGLTWSTH----NFTSTSVFVDGLLSEPGDETLVMTVFGHISFR 481
Query: 591 LESVSYVVDFSDAFKGASCKTSDMEDWYYSNGQ---CVDGTILKFRRRKQDAQCLIKTTY 647
+ VDF +F C D W SN Q C+ G FR+RK + C+ ++
Sbjct: 482 SDWELVKVDFRPSF-SRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSF 540
Query: 648 KDLTFEEELCGCSELDYECADDF-----SIDSAGKCVPDF 682
+C C + D+ C F S S KC +F
Sbjct: 541 TS-ALTSRVCECRDSDFLCDYGFERSSSSESSTNKCSANF 579
>Hs4507157_1 [R] KOG3511 Sortilin and related receptors
Length = 757
Score = 146 bits (369), Expect = 2e-34
Identities = 167/687 (24%), Positives = 294/687 (42%), Gaps = 103/687 (14%)
Query: 754 RESI-LFRTDKSEAYVSHDGGQNIKQIQT----GGEDILEINFNPFFNSSAYLFGKNKNL 808
R+S+ L R S+ YVS+D G++ K+I G + E F++S A NK
Sbjct: 122 RDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPA----DNKRY 177
Query: 809 FATHDYGLSFKVTELPAGRQLGFPLSFHAKDIQTFIYYGGESCESFFD---PNCHAVAYI 865
Y +T GF + F A D+ ++ + FD PN +
Sbjct: 178 IFADAYAQYLWITFDFCNTLQGFSIPFRAADL--LLHSKASNLLLGFDRSHPNKQL--WK 233
Query: 866 TRDGGASFEKLLEGASNCEFLESAVESPRVENGIVCMVKDKSTGARSYVSSTDYFKT--- 922
+ D G ++ + E + + + P + + + + +G + STD+F++
Sbjct: 234 SDDFGQTWIMIQEHVKSFSWGIDPYDKPNT----IYIERHEPSGYSTVFRSTDFFQSREN 289
Query: 923 QTVLYSDILGFMSTGGYI----VVAVSHGERQLRAYLTID----GVEYSEAVLPADLDSY 974
Q V+ ++ F Y+ VV + E+Q L + + ++ V ++ Y
Sbjct: 290 QEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEY 349
Query: 975 EQKAFTVLGSQEGAIFMHMTTNLDKNEEFGALLKSNTEGTSFVI-LERAVNRNSFG---- 1029
+ + E +F+ ++ + ++ L S EG F + LE + + G
Sbjct: 350 Y-----IADASEDQVFVCVSHSNNRTN----LYISEAEGLKFSLSLENVLYYSPGGAGSD 400
Query: 1030 ----------FVDFEKIQGLEGIILINTVANAKEIVESXXXXXXXXXXXXXXFNDGADWT 1079
F DF +++GL+G+ I T+ N E+ F+ G W
Sbjct: 401 TLVRYFANEPFADFHRVEGLQGVY-IATLINGSMNEENMRSVIT--------FDKGGTWE 451
Query: 1080 YIKPPSVDSEGKKYNCNPKNLEKCSLNL-HGFTERKDVR----DTYSSGSAIGYMFALGN 1134
+++ P+ G+K NC + CSL+L ++ +++ S SA G + A G+
Sbjct: 452 FLQAPAFTGYGEKINCELS--QGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGS 509
Query: 1135 VGEYLTPVSEASTFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLVKDNEPTDTVSYSING 1194
VG+ L S+ + ++++ G W E G + + +GDHG ++ + T+ + YS N
Sbjct: 510 VGKNLA--SKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNE 567
Query: 1195 GKTWKDYQFASEKINVYDLVTVPRDSAMRFLVIGSSVNVRGEETRTYTL---DFVDMFSR 1251
G+TWK + F+ + + VY L+T P + + F + GS+ E ++ + + D
Sbjct: 568 GETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSN----KENVHSWLILQVNATDALGV 623
Query: 1252 QCQYSKDDLKDFEYISLSHPNTKECLFGHKAKYLRKKSD-DCYVGMAPLEDKFR--IFAN 1308
C + D++ S S ECL GHK + R+ C+ G ED R + +N
Sbjct: 624 PCTEN-----DYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNG----EDFDRPVVVSN 674
Query: 1309 CSCTRNDYECDYNFMRVSDGTCKL------IDGLKPADPKDICSKDNSLIEYFEPTGYRK 1362
CSCTR DYECD+ F D + ++ G K P C ++ Y GYRK
Sbjct: 675 CSCTREDYECDFGFKMSEDLSLEVCVPDPEFSG-KSYSPPVPCPVGST---YRRTRGYRK 730
Query: 1363 IALSTCNGGLMLANSDSP-HPCPGKEK 1388
I+ TC+GG + A + PCP E+
Sbjct: 731 ISGDTCSGGDVEARLEGELVPCPLAEE 757
Score = 69.3 bits (168), Expect = 5e-11
Identities = 77/285 (27%), Positives = 121/285 (42%), Gaps = 35/285 (12%)
Query: 413 DFRSKVSFDLGNTWSKLKVSDPEGKWN-YNCDINSDSNDCGF-------QMFIVYGGGVE 464
+ RS ++FD G TW L+ G NC++ S C Q+ + +
Sbjct: 437 NMRSVITFDKGGTWEFLQAPAFTGYGEKINCEL---SQGCSLHLAQRLSQLLNLQLRRMP 493
Query: 465 GDSDIFSPGIIAAIGDVYEENPSGDFLKMGTFISRDDGSTWEKVLDFPSRVVMGDYGNII 524
S +PG+I A G V + S K +IS G+ W + L P GD+G II
Sbjct: 494 ILSKESAPGLIIATGSVGKNLAS----KTNVYISSSAGARWREALPGPHYYTWGDHGGII 549
Query: 525 LAVPFDPESDKDPQSEFYFSLDQGKTFQEYQL-DKSFYPTELLPSALDGSGNSFMLVGTI 583
A+ E+ +E +S ++G+T++ + +K + LL + S V TI
Sbjct: 550 TAIAQGMET-----NELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKS-----TVFTI 599
Query: 584 MSEDYQNLES-VSYVVDFSDAFKGASCKTSDMEDWYYSN---GQCVDGTILKFRRRKQDA 639
+ +N+ S + V+ +DA G C +D + W S+ +C+ G F+RR A
Sbjct: 600 FGSNKENVHSWLILQVNATDAL-GVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHA 658
Query: 640 QCLIKTTYKDLTFEEELCGCSELDYECADDFSID---SAGKCVPD 681
C + D C C+ DYEC F + S CVPD
Sbjct: 659 TCFNGEDF-DRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPD 702
>Hs17149834 [R] KOG3511 Sortilin and related receptors
Length = 831
Score = 139 bits (349), Expect = 5e-32
Identities = 146/656 (22%), Positives = 287/656 (43%), Gaps = 91/656 (13%)
Query: 751 TFVRESILFRTDKSEAYVSHDGGQNIKQIQTGGEDILEINFNPFFNS------------- 797
TF ++ +S+ Y S D G+N K DI ++ N F +
Sbjct: 129 TFHVPLVIMTFGQSKLYRSEDYGKNFK-------DITDLINNTFIRTEFGMAIGPENSGK 181
Query: 798 ---SAYLFGKNKN--LFATHDYGLSFKVTELPAGRQLGFPLSFHAKDIQTFIYYGGESCE 852
+A + G ++ +F + D+ +F T+LP FH T + Y ++ +
Sbjct: 182 VVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLP----------FHPL---TQMMYSPQNSD 228
Query: 853 SFFDPNCHAVAYITRDGGASFEKLLEGASNCEF-LESAVESPRVENGIVCMVKDKSTGAR 911
+ +++++ G +E++ + ++ ++ + NG GA
Sbjct: 229 YLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSC----KADLGAL 284
Query: 912 SYVSSTDYFKTQTVLYSDILGFMSTGGYIVVAV-SHGERQLRAYLTID-GVEYSEAVLPA 969
++D K+ + I F G ++ +V + + R +++ D G +S A LP+
Sbjct: 285 ELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPS 344
Query: 970 DLDSYEQKAFTVLGSQEGAIFMHMTTNLDKNEEFGALLKSNTEGTSFV-ILERAVNRNSF 1028
+++ +++L + + +FMH+ D FG + S+ G + L+R + +
Sbjct: 345 ---VGQEQFYSILAANDDMVFMHVDEPGDTG--FGTIFTSDDRGIVYSKSLDRHLYTTTG 399
Query: 1029 GFVDFEKIQGLEGIILINTVANAKEIVESXXXXXXXXXXXXXXFNDGADWTYIKPPSVDS 1088
G DF + L G+ + + ++ I F+ G WT+++ P
Sbjct: 400 GETDFTNVTSLRGVYITSVLSEDNSI------------QTMITFDQGGRWTHLRKP---- 443
Query: 1089 EGKKYNCNPKNLEKCSLNLHG---FTERKDV-RDTYSSGSAIGYMFALGNVGEYLTPVSE 1144
E + + KN +CSL++H +++ +V S +A+G + A G+VG+ ++ V
Sbjct: 444 ENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAIS-VMV 502
Query: 1145 ASTFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLVK-DNEPTDTVSYSINGGKTWKDYQF 1203
++++DGG SW+++ +G + + D G ++V ++ + P + + +S + G+ W+ Y F
Sbjct: 503 PDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTF 562
Query: 1204 ASEKINVYDLVTVPRDSAMRFLVIGSSVNVRGEETRTYTLDFVDMFSRQCQYSKDDLKDF 1263
+ I L + P +M + G + + + +YT+DF D+ R C+ KD+
Sbjct: 563 TRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEE-----KDY 617
Query: 1264 EYISLSHPNTKE-----CLFGHKAKYLR-KKSDDCYVGMAPLEDKFRIFANCSCTRNDYE 1317
I L+H E C+ G+K ++LR +KS C G + K + C C+ D+
Sbjct: 618 T-IWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQP--SICLCSLEDFL 674
Query: 1318 CDYNFMR-VSDGTCKLIDGLKPADPKDICSKDNSLIEYFEPTGYRKIALSTCNGGL 1372
CD+ + R +D C LK D + C E+ GYRKI C GG+
Sbjct: 675 CDFGYYRPENDSKCVEQPELKGHD-LEFCLYGRE--EHLTTNGYRKIPGDKCQGGV 727
Score = 72.4 bits (176), Expect = 5e-12
Identities = 71/280 (25%), Positives = 120/280 (42%), Gaps = 31/280 (11%)
Query: 415 RSKVSFDLGNTWSKLKVSDPEGKWNYNCDINS-DSNDCGFQMFIVYGGGVEGDSDIFSPG 473
++ ++FD G W+ L+ PE N CD + + N+C + Y + + +
Sbjct: 426 QTMITFDQGGRWTHLR--KPE---NSECDATAKNKNECSLHIHASYSISQKLNVPMAPLS 480
Query: 474 IIAAIGDVYEENPSGDFLKM---GTFISRDDGSTWEKVLDFPSRVVMGDYGNIILAVPFD 530
A+G V GD + + +IS D G +W K+L+ P + D G II+A+
Sbjct: 481 EPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAI--- 537
Query: 531 PESDKDPQSEFYFSLDQGKTFQEYQLDKSFYPTELLPSALDGSGNSFMLVGTIMSEDYQN 590
E P + FS D+G+ +Q Y + P A + S + +E +
Sbjct: 538 -EHSSRPINVIKFSTDEGQCWQTYTFTRD--PIYFTGLASEPGARSMNISIWGFTESFLT 594
Query: 591 LESVSYVVDFSDAFKGASCKTSDMEDWY--------YSNGQCVDGTILKFRRRKQDAQCL 642
+ VSY +DF D + +C+ D W Y +G C+ G +F R ++ + C
Sbjct: 595 SQWVSYTIDFKDILE-RNCEEKDYTIWLAHSTDPEDYEDG-CILGYKEQFLRLRKSSVCQ 652
Query: 643 IKTTYKDLTFEEELCGCSELDYECADDFSI---DSAGKCV 679
Y +T + +C CS D+ C DF ++ KCV
Sbjct: 653 NGRDYV-VTKQPSICLCSLEDFLC--DFGYYRPENDSKCV 689
>Hs18379342 [R] KOG3511 Sortilin and related receptors
Length = 1168
Score = 130 bits (327), Expect = 2e-29
Identities = 114/442 (25%), Positives = 191/442 (42%), Gaps = 67/442 (15%)
Query: 973 SYEQKAFTVLGSQEGAIFMHM-TTNLDKNEEFGALLK-----------SNTEGTSFVILE 1020
SY + AF + + A+ M + D+N+ F A+ + S+T G F +
Sbjct: 393 SYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTLAL 452
Query: 1021 RAV--NRNSFG--FVDFEKIQGLEGIILINTVANAKEIVESXXXXXXXXXXXXXXFNDGA 1076
V +R G +D ++ G++G+ L N + + +N G
Sbjct: 453 ENVQSSRGPEGNIMIDLYEVAGIKGMFLANKKIDNQ-------------VKTFITYNKGR 499
Query: 1077 DWTYIKPPSVDSEGKKYNCNPKNLEKCSLNLHGFTERKDVRDTYSSG------SAIGYMF 1130
DW ++ P D G +C L CSL+LH K + Y+SG +A +
Sbjct: 500 DWRLLQAPDTDLRGDPVHCL---LPYCSLHLH----LKVSENPYTSGIIASKDTAPSIIV 552
Query: 1131 ALGNVGEYLTPVSEASTFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLVKDNE-PTDTVS 1189
A GN+G L+ ++ S F+++D G +W ++ + + Y D G VLV +K P +
Sbjct: 553 ASGNIGSELSD-TDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLW 611
Query: 1190 YSINGGKTWKDYQFASEKINVYDLVTVPRDSAMRFLVIGSSVNVRGEETRTYTLDFVDMF 1249
S + G++W Y F S + V ++ P + + V G + E + +D+ +F
Sbjct: 612 LSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSH--RSEWQLVKVDYKSIF 669
Query: 1250 SRQCQYSKDDLKDFEYISLSHPNTKECLFGHKAKYLRKKSD-DC----YVGMAPLEDKFR 1304
R+C +++D + ++ H + C+ G K Y ++KS+ C Y G E
Sbjct: 670 DRRC--AEEDYRPWQL----HSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP--- 720
Query: 1305 IFANCSCTRNDYECDYNFMRVSDGTCKLIDGLKPADPKDICSKDNSLIEYFEPTGYRKIA 1364
C CT D++CDY + R S+G C P+ CS S Y TGYRK+
Sbjct: 721 ----CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQS---YLNSTGYRKVV 773
Query: 1365 LSTCNGGLMLANSDSPHPCPGK 1386
+ C G+ + P CPGK
Sbjct: 774 SNNCTDGVREQYTAKPQKCPGK 795
Score = 77.8 bits (190), Expect = 1e-13
Identities = 62/242 (25%), Positives = 108/242 (44%), Gaps = 19/242 (7%)
Query: 459 YGGGVEGDSDIFSPGIIAAIGDVYEENPSGDFLKMGTFISRDDGSTWEKVLDFPSRVVMG 518
Y G+ D +P II A G++ E D + F+S D G+TW ++ + V+
Sbjct: 536 YTSGIIASKDT-APSIIVASGNIGSELSDTD---ISMFVSSDAGNTWRQIFEEEHSVLYL 591
Query: 519 DYGNIILAVPFDPESDKDPQSEFYFSLDQGKTFQEYQLDKSFYPTELLPSALDGSGNSFM 578
D G +++A+ + P + S D+G+++ +Y SF L + G
Sbjct: 592 DQGGVLVAM----KHTSLPIRHLWLSFDEGRSWSKY----SFTSIPLFVDGVLGEPGEET 643
Query: 579 LVGTIMSEDYQNLESVSYVVDFSDAFKGASCKTSDMEDWY-YSNGQ-CVDGTILKFRRRK 636
L+ T+ E VD+ F C D W +S G+ C+ G +++RK
Sbjct: 644 LIMTVFGHFSHRSEWQLVKVDYKSIFD-RRCAEEDYRPWQLHSQGEACIMGAKRIYKKRK 702
Query: 637 QDAQCLIKTTYKDLTFEEELCGCSELDYECADDFSIDSAGKCVPD--FSKASLMEKCESK 694
+ +C+ + Y E E C C+E D++C + S G+C+P F+ +SL + C
Sbjct: 703 SERKCM-QGKYAG-AMESEPCVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLG 760
Query: 695 KS 696
+S
Sbjct: 761 QS 762
>Hs18379346 [R] KOG3511 Sortilin and related receptors
Length = 1222
Score = 122 bits (306), Expect = 5e-27
Identities = 110/438 (25%), Positives = 185/438 (42%), Gaps = 58/438 (13%)
Query: 973 SYEQKAFTVLGSQEGAI--FMHMTTNLDKNEEFGALLK-----------SNTEGTSFVIL 1019
SY ++AF + + ++ MH+ + D+N+ F A+ + S+T G F +
Sbjct: 416 SYRREAFAQIKLPKYSLPKDMHIIST-DENQVFAAVQEWNQNDTYNLYISDTRGIYFTLA 474
Query: 1020 ERAV--NRNSFG--FVDFEKIQGLEGIILINTVANAKEIVESXXXXXXXXXXXXXXFNDG 1075
+ +R G ++ ++ G++GI L N + + +N G
Sbjct: 475 MENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQ-------------VKTYITYNKG 521
Query: 1076 ADWTYIKPPSVDSEGKKYNCNPKNLEKCSLNLHGFTERKDVRDTYSSG------SAIGYM 1129
DW ++ P VD G +C L CSL+LH + + YSSG +A G +
Sbjct: 522 RDWRLLQAPDVDLRGSPVHCL---LPFCSLHLH----LQLSENPYSSGRISSKETAPGLV 574
Query: 1130 FALGNVGEYLTPVSEASTFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLVKDNE-PTDTV 1188
A GN+G L+ ++ F+++DGG +W ++ Y + D G LV +K P +
Sbjct: 575 VATGNIGPELS-YTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHL 633
Query: 1189 SYSINGGKTWKDYQFASEKINVYDLVTVPRDSAMRFLVIGSSVNVRGEETRTYTLDFVDM 1248
S + G +W Y F S + V D V + + ++R E + +D+ +
Sbjct: 634 WVSFDEGHSWDKYGFTSVPLFV-DGALVEAGMETHIMTVFGHFSLRSE-WQLVKVDYKSI 691
Query: 1249 FSRQCQYSKDDLKDFEYISLSHPNTKECLFGHKAKYLRKKSDDCYVGMAPLEDKFRIFAN 1308
FSR C +K+D + + ++ P C+ G + K +K+ + +
Sbjct: 692 FSRHC--TKEDYQTWHLLNQGEP----CVMGER-KIFKKRKPGAQCALGRDHSGSVVSEP 744
Query: 1309 CSCTRNDYECDYNFMRVSDGTCKLIDGLKPADPKDICSKDNSLIEYFEPTGYRKIALSTC 1368
C C D+ECDY + R + C PA P CS S Y TGYR+I + C
Sbjct: 745 CVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQS---YLNSTGYRRIVSNNC 801
Query: 1369 NGGLMLANSDSPHPCPGK 1386
GL + CPGK
Sbjct: 802 TDGLREKYTAKAQMCPGK 819
Score = 74.3 bits (181), Expect = 1e-12
Identities = 59/233 (25%), Positives = 97/233 (41%), Gaps = 23/233 (9%)
Query: 471 SPGIIAAIGDVYEENPSGDFLKMGTFISRDDGSTWEKVLDFPSRVVMGDYGNIILAVPFD 530
+PG++ A G++ P + +G FIS D G+TW ++ D V D+G ++A+
Sbjct: 570 APGLVVATGNI---GPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHT 626
Query: 531 PESDKDPQSEFYFSLDQGKTFQEYQLDKSFYPTELLPSALDGS---GNSFMLVGTIMSED 587
P P + S D+G ++ +Y +P +DG+ + T+
Sbjct: 627 PL----PVRHLWVSFDEGHSWDKYGFTS-------VPLFVDGALVEAGMETHIMTVFGHF 675
Query: 588 YQNLESVSYVVDFSDAFKGASCKTSDMEDWYYSN--GQCVDGTILKFRRRKQDAQCLIKT 645
E VD+ F C D + W+ N CV G F++RK AQC +
Sbjct: 676 SLRSEWQLVKVDYKSIF-SRHCTKEDYQTWHLLNQGEPCVMGERKIFKKRKPGAQCALGR 734
Query: 646 TYKDLTFEEELCGCSELDYECADDFSIDSAGKCVPDF--SKASLMEKCESKKS 696
+ E C C+ D+EC + +CVP F + AS + C +S
Sbjct: 735 DHSGSVVSEP-CVCANWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQS 786
>YCR100c [R] KOG3511 Sortilin and related receptors
Length = 316
Score = 119 bits (297), Expect = 5e-26
Identities = 109/337 (32%), Positives = 155/337 (45%), Gaps = 45/337 (13%)
Query: 291 SAANLWRLEDDSTDKFEQISLGTQIR--KSLMDVNEIDGRAIITIYHXXXXXXXXXXXXX 348
S+ ++W D ST F++ L TQ+R K + + GR I+ I
Sbjct: 2 SSTDIWISNDAST--FQKAQLPTQLRHVKVIKIREDSIGRIILLI-------------ST 46
Query: 349 XXSPFEDIFSGSIEALISDSYGKNFRHLSFD-EQKASSLTLSTSIFVKKTMFAT------ 401
+ E+ E ISDS G F + + + + L+ F+K T+F +
Sbjct: 47 EITNEENADPDLSEIFISDSQGLKFSPVEWTPNHQFGNFRLTFPDFLKGTIFGSFHPSID 106
Query: 402 WTNTMRDF--GFFDFRSKVSFDLGNTWSKLKVSDPEGKWNYNCDINSDSNDCGFQMFIVY 459
++N ++ +K+S D G TWS LKV D E ++ CDI C Q + Y
Sbjct: 107 YSNHQVNYTENIAGGETKISVDNGLTWSNLKVVDEENADSFGCDITRPER-CSLQGYF-Y 164
Query: 460 GGGVEGDSDIFSPGIIAAIGDVYEENPSGDFLKMGTFISRDDGSTWEKVLDFPSRVVMGD 519
+ S GII G V ++N D TFISRD G TW + GD
Sbjct: 165 NLKLSNPS----AGIILMTGSVGDDNEF-DRKDRKTFISRDGGLTWRVAHNSSGLYATGD 219
Query: 520 YGNIILAVPFDPESDKDPQSEFYFSLDQGKTFQEYQL-DKSFY--PTELLPSALDGSGNS 576
GNII+ +P D D QS+ YFSLDQG+T+ +Y+L D FY P EL+ + DGSG+
Sbjct: 220 LGNIIVYIPSPSYKDGDVQSKLYFSLDQGRTWNQYELVDALFYIHPLELINTTPDGSGSK 279
Query: 577 FMLVG---TIMSEDYQN------LESVSYVVDFSDAF 604
F+L G T S++ N SV Y +DFS AF
Sbjct: 280 FILSGHLITTASQEGNNTNISYIARSVLYAIDFSAAF 316
Score = 60.1 bits (144), Expect = 3e-08
Identities = 41/184 (22%), Positives = 82/184 (44%), Gaps = 19/184 (10%)
Query: 1073 NDGADWTYIKPPSVDSEGK-KYNCNPKNLEKCSLNLHGFTERKDVRDTYSSGSAIGYMFA 1131
++G W+ +K VD E + C+ E+CSL + + + S + G +
Sbjct: 128 DNGLTWSNLKV--VDEENADSFGCDITRPERCSLQGYFYNLKL-------SNPSAGIILM 178
Query: 1132 LGNVGEYLT-PVSEASTFMTNDGGISWSEVKKGSYQWEYGDHGSVLVLV-----KDNEPT 1185
G+VG+ + TF++ DGG++W S + GD G+++V + KD +
Sbjct: 179 TGSVGDDNEFDRKDRKTFISRDGGLTWRVAHNSSGLYATGDLGNIIVYIPSPSYKDGDVQ 238
Query: 1186 DTVSYSINGGKTWKDYQFASEKINVYDLV---TVPRDSAMRFLVIGSSVNVRGEETRTYT 1242
+ +S++ G+TW Y+ ++ L T P S +F++ G + +E
Sbjct: 239 SKLYFSLDQGRTWNQYELVDALFYIHPLELINTTPDGSGSKFILSGHLITTASQEGNNTN 298
Query: 1243 LDFV 1246
+ ++
Sbjct: 299 ISYI 302
>YCR099c [R] KOG3511 Sortilin and related receptors
Length = 155
Score = 112 bits (281), Expect = 4e-24
Identities = 53/143 (37%), Positives = 86/143 (60%), Gaps = 7/143 (4%)
Query: 604 FKGASCKTSDMEDWYYSNGQCVDGTILKFRRRKQDAQCLIKTTYKDLTFEEELC-GCSEL 662
F +C+ D EDW ++G+C++G ++RRKQDA+CL+K T+KD+ E C C+E
Sbjct: 9 FDYKTCEEEDFEDWNLADGKCLNGAKYMYKRRKQDARCLVKRTFKDMILHEIPCDSCTES 68
Query: 663 DYECADDFSIDSAGKCVPDFSKASLMEKCE--SKKSIQLEPKKISKTTKCKRPQNIIKEE 720
DYEC+ +F D+ G C+PD+ + +L + C+ + +++ LEP ++ K KCK+P I
Sbjct: 69 DYECSSEFVRDAKGDCIPDYDQIALSDICDKANGETVSLEPLQLIKGDKCKKPMEIEAMN 128
Query: 721 ISCAAVPAPSN----VKVTENKF 739
I C + S+ + ENKF
Sbjct: 129 IPCEKILRESSNGKKIATIENKF 151
>YNR066c [R] KOG3511 Sortilin and related receptors
Length = 436
Score = 88.6 bits (218), Expect = 7e-17
Identities = 105/448 (23%), Positives = 190/448 (41%), Gaps = 70/448 (15%)
Query: 20 AQDFKPKVSFHSDVDTHGRLSILGFDDSRVVLKLLRGVELYRSEDNGVTWDSVGLPLSSD 79
A++F PKV+ + + S+ FDDS +++L V ++ S D+G W++V
Sbjct: 21 AEEFVPKVT---ETLSEYSFSLESFDDSNSLIRLDNQV-VWISSDSGENWEAV------- 69
Query: 80 NKPQEWN--HLVLDRIYKADVAYLSGENG--VLATGDKGKSWKQLTFLDADNHKIDFSDY 135
K E + L++D ++ D A++S T D+GKSW+ LT ++N ++ S
Sbjct: 70 -KEIEGHILELIVDPLHGQDRAFVSIHLSPKFYVTDDRGKSWRALTIPVSENCRLGTS-- 126
Query: 136 SNVGDENRKPIINVEIESHPTNKNARIINIYELGKLDGKFTLRQISFYSKDGNNFKLASS 195
I +HPT+K I + +G ++ ++++ DG +F
Sbjct: 127 -------------CSIATHPTDKKYLIADCPCFINDNGYIQIQNETYFTNDGESFYNIEP 173
Query: 196 GSKSNDDSNPLNMFCSFVQXXXXXXXXXXXXXVICQESTVLSPFGDVSSK--------LY 247
K +D + + C+FV+ ++C + S G S + L
Sbjct: 174 SLKKKEDDHITSSSCNFVKSSKDSDIEGNDASILC----LFSNHGYDSDRHLSAAYTQLA 229
Query: 248 ITDVNFKSLSPFAEQLQDLSPASTFISDNHLFILTLSDRFNENSAANLWRLEDDSTDKFE 307
++ K+ F ++ D I +H+ + T DR+NE S ++W D ST F+
Sbjct: 230 LSTDGGKTFKKF-DEFNDKIIYQYKILKSHIIVSTQDDRYNEMSPMDIWISNDAST--FQ 286
Query: 308 QISLGTQIRKSLMD--VNEIDGRAIITIYHXXXXXXXXXXXXXXXSPFEDIFSGSIEALI 365
+ L Q+R M + GR II I + ++ E LI
Sbjct: 287 KARLPAQVRHVHMYGIYEDSIGRIIIPI-------------STIFTDEKNDQPAPSEILI 333
Query: 366 SDSYGKNFRHLSFD-EQKASSLTLSTSIFVKKTMFATWTNTM---RDFGFFD-----FRS 416
SDS G F + + + +++ F++ T+ ++ + + G ++ + +
Sbjct: 334 SDSQGLKFLPVEWTINPHFGYIDIASPHFLEGTIIGSFHPSFDYSHNKGKYNKKIARYET 393
Query: 417 KVSFDLGNTWSKLKVSDPEGKWNYNCDI 444
K+S D G TWS LKV D E ++ CDI
Sbjct: 394 KISVDNGLTWSNLKVVDEENADSFPCDI 421
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.136 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,014,270
Number of Sequences: 60738
Number of extensions: 4565331
Number of successful extensions: 10436
Number of sequences better than 1.0e-05: 13
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 10238
Number of HSP's gapped (non-prelim): 40
length of query: 1566
length of database: 30,389,216
effective HSP length: 120
effective length of query: 1446
effective length of database: 23,100,656
effective search space: 33403548576
effective search space used: 33403548576
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)