ORF      STATUS       Function Best COG  Functional category                                          Pathways and functional systems
r_klactV3050    suspect: LH   I     KOG1933  Lipid transport and metabolism                                 Cholesterol transport protein (Niemann-Pick C disease protein)

BLASTP 2.2.3 [May-13-2002]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= r_klactV3050 1055838  1059563 1242 
         (1242 letters)

Database: KOG eukaryal database 04/03 
           60,738 sequences; 30,389,216 total letters

Searching..................................................done

Color Key for Alignment Scores:   


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

SPBC3B9.15c [I] KOG1933 Cholesterol transport protein (Niemann-P...    54   2e-06

>SPBC3B9.15c [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
           protein)
          Length = 1086

 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 36/168 (21%), Positives = 73/168 (43%), Gaps = 16/168 (9%)

Query: 244 IVSFFIYNMEHMKSVKSPFGISVAIIAQLILTLYTGKAVTCFFFKTSSDNIPWFLIYIPI 303
           + ++   ++  +  +++ FG++  I  Q   T Y       +FF+ +    PW + Y  I
Sbjct: 244 LFAYLYLSLVRLHDIRAKFGLTATIFIQSG-TAYFSTCSLLYFFERTGPICPWPMAYYII 302

Query: 304 MFASLSNLFKLTIEKKGTIFIEREPVFIQTSNDQTNTPPFLSSQQDFLNSMVKSNRDTLR 363
           +F  + N F+L      +   +R P  I                + F ++++ S    L+
Sbjct: 303 IFMDIENSFRLLRAVIASPQTKRVPSRIM---------------EGFSSTIIASFSSLLK 347

Query: 364 TTLAMLILLVIITPFSRKVCCFFITALLTNLFLQITYFCAVLSLDHRR 411
             L + +L   + P  ++ C F   + + +  L  ++F AVLS+D RR
Sbjct: 348 KLLTLFVLSFFVYPLVQEFCLFLACSFVVSFLLHGSFFLAVLSVDIRR 395


  Database: KOG eukaryal database 04/03
    Posted date:  Apr 14, 2003  1:07 PM
  Number of letters in database: 30,389,216
  Number of sequences in database:  60,738
  
Lambda     K      H
   0.321    0.136    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,424,052
Number of Sequences: 60738
Number of extensions: 2726297
Number of successful extensions: 6564
Number of sequences better than 1.0e-05: 1
Number of HSP's better than  0.0 without gapping: 0
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 6560
Number of HSP's gapped (non-prelim): 4
length of query: 1242
length of database: 30,389,216
effective HSP length: 118
effective length of query: 1124
effective length of database: 23,222,132
effective search space: 26101676368
effective search space used: 26101676368
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)