ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV3443 good BK KOG3001 Chromatin structure and dynamics Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins
r_klactV3443 good BK KOG3001 Transcription Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV3443 1192678 1191605 -358
(358 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPR023c [BK] KOG3001 Dosage compensation regulatory complex/hist... 259 4e-69
SPAC23H4.12 [BK] KOG3001 Dosage compensation regulatory complex/... 148 1e-35
Hs5803102 [BK] KOG3001 Dosage compensation regulatory complex/hi... 135 9e-32
Hs6912448 [BK] KOG3001 Dosage compensation regulatory complex/hi... 107 4e-23
7299989 [BK] KOG3001 Dosage compensation regulatory complex/hist... 103 4e-22
At4g37280 [BK] KOG3001 Dosage compensation regulatory complex/hi... 93 5e-19
Hs6996928 [BK] KOG3001 Dosage compensation regulatory complex/hi... 93 7e-19
At1g02740 [BK] KOG3001 Dosage compensation regulatory complex/hi... 78 2e-14
CE20213 [BK] KOG3001 Dosage compensation regulatory complex/hist... 57 5e-08
>YPR023c [BK] KOG3001 Dosage compensation regulatory complex/histone
acetyltransferase complex subunit MSL-3/MRG15/EAF3 and
related CHROMO domain-containing proteins
Length = 401
Score = 259 bits (662), Expect = 4e-69
Identities = 148/397 (37%), Positives = 217/397 (54%), Gaps = 48/397 (12%)
Query: 5 LDGKCLCYHGPLLYEAKVLRVYDEKNQTITS-------------KDYKDVSI-DDEKVEF 50
L G+CL +HGPL+YEAK+L+++D ++ TS K+ K + +DE +
Sbjct: 10 LGGRCLAFHGPLMYEAKILKIWDPSSKMYTSIPNDKPGGSSQATKEIKPQKLGEDESI-- 67
Query: 51 DRPPEHMRQGQCYFVHYQGWKSSWDEWVGLDRIRPYNDENLELKKSLVEKARELXXXXXX 110
PE + G+C+F+HYQGWKSSWDEWVG DRIR YN+EN+ +KK L +A+E
Sbjct: 68 ---PEEIINGKCFFIHYQGWKSSWDEWVGYDRIRAYNEENIAMKKRLANEAKEAKKSLLE 124
Query: 111 XXXXXR---PVGRPSKVEKGKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 167
+ +G PS K K
Sbjct: 125 QQKKKKLSTSLGGPSNGGKRKGDSRSNASISKSTSQSFLTSSVSGRKSGRSSANSLHPGS 184
Query: 168 XDKS--------DRKKATPVLNKRSH-------PKIHIKVPISLRSVLVDDWENVTKDRK 212
+S DR++++ + H PKI +++PI L+SVLVDDWE VTKD+K
Sbjct: 185 SLRSSSDQNGNDDRRRSSSLSPNMLHHIAGYPTPKISLQIPIKLKSVLVDDWEYVTKDKK 244
Query: 213 LVQLPSERPIEHILSQFYADTSNSTSSVVEQAQLSEFLQGIKLYFNLSLGKLLLYRLERI 272
+ +LP++ +E +L+++ + S S Q+QLSE+ G+KLYF+ LG +LLYRLER+
Sbjct: 245 ICRLPADVTVEMVLNKYEHEVSQELESPGSQSQLSEYCAGLKLYFDKCLGNMLLYRLERL 304
Query: 273 QYAELLKAHSEKQY----TEIYGIIHLLRLVTLLPEMMESSNVDDQTAKILVKQCDILLE 328
QY ELLK S+ Q IYG IHLLRL+++LPE++ S+ +D Q+ ++L+KQ + L
Sbjct: 305 QYDELLKKSSKDQKPLVPIRIYGAIHLLRLISVLPELISSTTMDLQSCQLLIKQTEDFLV 364
Query: 329 WIAINIARKNFPVDP-------YINTSSQYEGVALSM 358
W+ +++ DP Y+NTSSQYEGVAL M
Sbjct: 365 WLLMHVDEYFNDKDPNRSDDALYVNTSSQYEGVALGM 401
>SPAC23H4.12 [BK] KOG3001 Dosage compensation regulatory complex/histone
acetyltransferase complex subunit MSL-3/MRG15/EAF3 and
related CHROMO domain-containing proteins
Length = 337
Score = 148 bits (373), Expect = 1e-35
Identities = 92/356 (25%), Positives = 156/356 (42%), Gaps = 40/356 (11%)
Query: 8 KCLCYHGPLLYEAKVLRVYDEKNQTITSKDYKDVSIDDEKVEFDRPPEHMRQGQCYFVHY 67
+ LC+HGPLLYEAK+ V E +T+ Y +HY
Sbjct: 10 RVLCFHGPLLYEAKI--VDTEMKGDVTT---------------------------YLIHY 40
Query: 68 QGWKSSWDEWVGLDRIRPYNDENLELKKSLVEKARELXXXXXXXXXXXRPVGRPSKVEK- 126
+GWK+SWDEWV DRI + +ENL+ +K L A S K
Sbjct: 41 KGWKNSWDEWVEQDRILQWTEENLKTQKELKNAAISTRQKPTSKKSASSTSKHDSTGVKT 100
Query: 127 -GKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDKSDRKKATPVLNKRSH 185
GK+ D + + P N++
Sbjct: 101 SGKRSRESSTVTVDGDSHELPSRIKTQKSESPIPQQVKRDGTTDAKNEETTKPENNEKDD 160
Query: 186 -------PKIHIKVPISLRSVLVDDWENVTKDRKLVQLPSERPIEHILSQFYADTSNSTS 238
PK I VP L+ LVDDWEN+TK+++L+ +P + ++ F + +
Sbjct: 161 FEEEPPLPKHKISVPDVLKLWLVDDWENITKNQQLIAIPRNPTVRAAIAAFRESKISHLN 220
Query: 239 SVVEQAQLSEFLQGIKLYFNLSLGKLLLYRLERIQYAELLKAHSEKQYTEIYGIIHLLRL 298
+ ++ + + G+ +YFN LG +LLYR ER QY E+ + + + + ++YG+ HL+RL
Sbjct: 221 NEIDVDVFEQAMAGLVIYFNKCLGNMLLYRFERQQYLEIRQQYPDTEMCDLYGVEHLIRL 280
Query: 299 VTLLPEMMESSNVDDQTAKILVKQCDILLEWIAINIARKNFPVDPYINTSSQYEGV 354
LPE+++ +N+D Q+ + L+ + L+++ ++ + + + Y N Y +
Sbjct: 281 FVSLPELIDRTNMDSQSIECLLNYIEEFLKYLVLH--KDEYFIKEYQNAPPNYRSL 334
>Hs5803102 [BK] KOG3001 Dosage compensation regulatory complex/histone
acetyltransferase complex subunit MSL-3/MRG15/EAF3 and
related CHROMO domain-containing proteins
Length = 323
Score = 135 bits (340), Expect = 9e-32
Identities = 87/332 (26%), Positives = 151/332 (45%), Gaps = 48/332 (14%)
Query: 8 KCLCYHGPLLYEAKVLRVYDEKNQTITSKDYKDVSIDDEKVEFDRPPEHMRQGQCYFVHY 67
+ LC+HGPLLYEAK ++V +I D++V+ YF+HY
Sbjct: 16 RVLCFHGPLLYEAKCVKV----------------AIKDKQVK-------------YFIHY 46
Query: 68 QGWKSSWDEWVGLDRIRPYNDENLELKKSLVEKARELXXXXXXXXXXXRPVGRPSKVEKG 127
GW +WDEWV R+ Y D NL+ ++ L + +E G+ G
Sbjct: 47 SGWNKNWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAE-----------GKMRGAAPG 95
Query: 128 KKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDKSDRKKATPVLNKR---- 183
KK + R + P +
Sbjct: 96 KKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQP----PRKKRARVDPTVENEETFM 151
Query: 184 SHPKIHIKVPISLRSVLVDDWENVTKDRKLVQLPSERPIEHILSQFYADTSNSTSSVVEQ 243
+ ++ +K+P L+ LVDDW+ +T+ ++L LP+++ ++ IL + + ++ ++
Sbjct: 152 NRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKE 211
Query: 244 AQLSEFLQGIKLYFNLSLGKLLLYRLERIQYAELLKAHSEKQYTEIYGIIHLLRLVTLLP 303
++E + GIK YFN+ LG LLY+ ER QYAE+L H + +++YG HLLRL +
Sbjct: 212 YAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIG 271
Query: 304 EMMESSNVDDQTAKILVKQCDILLEWIAINIA 335
M+ + +D+++ +L+ L+++A N A
Sbjct: 272 AMLAYTPLDEKSLALLLNYLHDFLKYLAKNSA 303
>Hs6912448 [BK] KOG3001 Dosage compensation regulatory complex/histone
acetyltransferase complex subunit MSL-3/MRG15/EAF3 and
related CHROMO domain-containing proteins
Length = 288
Score = 107 bits (266), Expect = 4e-23
Identities = 63/192 (32%), Positives = 112/192 (57%), Gaps = 7/192 (3%)
Query: 170 KSDRKKATPVLNK----RSHPKIHIKVPISLRSVLVDDWENVTKDRKLVQLPSERPIEHI 225
+ R +A P + ++ ++ +K+P L+ LV+DW+ VT+ ++L QLP+++ ++ I
Sbjct: 99 RKKRARADPTVESEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAI 158
Query: 226 LSQFYADTSNSTSSVV-EQAQLSEFLQGIKLYFNLSLGKLLLYRLERIQYAELLKAHSEK 284
L + YA+ S +V ++ ++E + GIK YFN+ LG LLY+ ER QYAE+L AH +
Sbjct: 159 LEE-YANCKKSQGNVDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILLAHPDA 217
Query: 285 QYTEIYGIIHLLRLVTLLPEMMESSNVDDQTAKILVKQCDILLEWIAINIARKNFPVDPY 344
+++YG HLLRL + M+ + +D+++ +L+ L+++A N A F Y
Sbjct: 218 PMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSA-SLFTASDY 276
Query: 345 INTSSQYEGVAL 356
S++Y AL
Sbjct: 277 KVASAEYHRKAL 288
>7299989 [BK] KOG3001 Dosage compensation regulatory complex/histone
acetyltransferase complex subunit MSL-3/MRG15/EAF3 and
related CHROMO domain-containing proteins
Length = 424
Score = 103 bits (257), Expect = 4e-22
Identities = 54/166 (32%), Positives = 96/166 (57%), Gaps = 2/166 (1%)
Query: 187 KIHIKVPISLRSVLVDDWENVTKDRKLVQLPSERPIEHILSQFYADTSN-STSSVVEQAQ 245
++ IK+P L+ L DDW V ++ KL++LP++ ++ I Q+ A + ++S ++
Sbjct: 255 EVKIKIPDELKHYLTDDWYAVVREHKLLELPAKVTVQQISEQYLAHKKSVKSTSASKEVA 314
Query: 246 LSEFLQGIKLYFNLSLGKLLLYRLERIQYAELLKAHSEKQYTEIYGIIHLLRLVTLLPEM 305
+++ L GI YFN+ LG LLY+ ER QYA++++ H + +E+YG HLLRL L M
Sbjct: 315 INDVLDGIVEYFNVMLGSQLLYKFERTQYADVMQKHPDTPLSELYGSFHLLRLFVRLGSM 374
Query: 306 MESSNVDDQTAKILVKQCDILLEWIAINIARKNFPVDPYINTSSQY 351
+ S +D Q+ + L+ L+++ N + F + +IN +Y
Sbjct: 375 LSYSALDQQSMQNLLTHVQDFLKFLVKN-SSIFFSMSNFINVDPEY 419
Score = 65.1 bits (157), Expect = 2e-10
Identities = 34/102 (33%), Positives = 51/102 (49%), Gaps = 30/102 (29%)
Query: 3 IVLDG-KCLCYHGPLLYEAKVLRVYDEKNQTITSKDYKDVSIDDEKVEFDRPPEHMRQGQ 61
+ +DG + LC+HGPL+YEAKVL+ T D V
Sbjct: 21 LFVDGERVLCFHGPLIYEAKVLK---------TKPDATPVE------------------- 52
Query: 62 CYFVHYQGWKSSWDEWVGLDRIRPYNDENLELKKSLVEKARE 103
Y++HY GW +WDEWV +R+ YND+N++ ++ L + E
Sbjct: 53 -YYIHYAGWSKNWDEWVPENRVLKYNDDNVKRRQELARQCGE 93
>At4g37280 [BK] KOG3001 Dosage compensation regulatory complex/histone
acetyltransferase complex subunit MSL-3/MRG15/EAF3 and
related CHROMO domain-containing proteins
Length = 284
Score = 93.2 bits (230), Expect = 5e-19
Identities = 71/272 (26%), Positives = 113/272 (41%), Gaps = 59/272 (21%)
Query: 74 WDEWVGLDRIRPYNDENLELKKSLVEKARELXXXXXXXXXXXRPVGRPSKVEKGKKXXXX 133
WDEWV DR+ + +ENL +K+L +K VEKG K
Sbjct: 35 WDEWVSADRLLKHTEENLVKQKALDKK---------------------QGVEKGTKSGRS 73
Query: 134 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDKSDRKKATPVLNKRSHPK------ 187
DK D K KR H
Sbjct: 74 AQTKTRSSADTKA----------------------DKDDTKTNAAKGKKRKHESGNEKDN 111
Query: 188 ------IHIKVPISLRSVLVDDWENVTKDRKLVQLPSERPIEHILSQFYADTSNSTSSVV 241
+ I++P SL+ L DDWE + + K+V+LP ++ ILS++ + V
Sbjct: 112 VTAEKLMKIQIPASLKKQLTDDWEYIAQKDKVVKLPRSPNVDEILSKYLEFKTKKDGMVT 171
Query: 242 EQAQLSEFLQGIKLYFNLSLGKLLLYRLERIQYAELLKAHSEKQYTEIYGIIHLLRLVTL 301
+ ++E L+GI+ YF+ +L +LLY+ ER QY E + + + +YG HLLRL
Sbjct: 172 D--SVAEILKGIRSYFDKALPVMLLYKKERRQYQESIV--DDTSPSTVYGAEHLLRLFVK 227
Query: 302 LPEMMESSNVDDQTAKILVKQCDILLEWIAIN 333
LP++ N++++T + + L++I N
Sbjct: 228 LPDLFSYVNMEEETWSRMQQTLSDFLKFIQKN 259
>Hs6996928 [BK] KOG3001 Dosage compensation regulatory complex/histone
acetyltransferase complex subunit MSL-3/MRG15/EAF3 and
related CHROMO domain-containing proteins
Length = 235
Score = 92.8 bits (229), Expect = 7e-19
Identities = 47/149 (31%), Positives = 90/149 (59%)
Query: 187 KIHIKVPISLRSVLVDDWENVTKDRKLVQLPSERPIEHILSQFYADTSNSTSSVVEQAQL 246
++ +K+P L+ LVDDW+ +T+ ++L LP+E+ ++ IL + + ++ ++ +
Sbjct: 67 EVKVKIPEELKPWLVDDWDLITRQKQLFYLPAEKNVDSILEDYANYKKSHGNTDNKEYAV 126
Query: 247 SEFLQGIKLYFNLSLGKLLLYRLERIQYAELLKAHSEKQYTEIYGIIHLLRLVTLLPEMM 306
+E + GIK YFNL LG LL + ER QYAE+L + +++YG+ HLLRL + M+
Sbjct: 127 NEVVAGIKEYFNLMLGTQLLNKFERPQYAEILADCPDAPMSQVYGVPHLLRLSVQIGAML 186
Query: 307 ESSNVDDQTAKILVKQCDILLEWIAINIA 335
+ +++++ +L+ L+++A N A
Sbjct: 187 AYTPLNEKSLALLLNYLHDFLKYLAKNSA 215
>At1g02740 [BK] KOG3001 Dosage compensation regulatory complex/histone
acetyltransferase complex subunit MSL-3/MRG15/EAF3 and
related CHROMO domain-containing proteins
Length = 316
Score = 77.8 bits (190), Expect = 2e-14
Identities = 47/132 (35%), Positives = 73/132 (54%), Gaps = 4/132 (3%)
Query: 188 IHIKVPISLRSVLVDDWENVTKDRKLVQLPSERPIEHILSQFYADTSNSTSSVVEQAQLS 247
+ +P +LR L+DD+E VT+ +KLVQLP ++ IL ++ V + L
Sbjct: 158 LSFNIPPALRKQLLDDFEFVTQMQKLVQLPRSPNVDGILKKYIDSQMKKHGRVTD--SLE 215
Query: 248 EFLQGIKLYFNLSLGKLLLYRLERIQYAELLKAHSEKQYTEIYGIIHLLRLVTLLPEMME 307
E L+G++ YF+ +L +LLY ER QY E + + +YG HLLRL LPE++
Sbjct: 216 EILKGLRCYFDKALPVMLLYNNERKQYEESVSGGVSP--STVYGAEHLLRLFVKLPELLV 273
Query: 308 SSNVDDQTAKIL 319
N+ ++T K L
Sbjct: 274 HVNMAEETLKEL 285
>CE20213 [BK] KOG3001 Dosage compensation regulatory complex/histone
acetyltransferase complex subunit MSL-3/MRG15/EAF3 and
related CHROMO domain-containing proteins
Length = 335
Score = 56.6 bits (135), Expect = 5e-08
Identities = 51/220 (23%), Positives = 97/220 (43%), Gaps = 44/220 (20%)
Query: 170 KSDRKKATPVLNKRSHPKIHIKVPISLRSVLVDDWENVTKDRKLVQL-PSERPIEHILSQ 228
K + K+ + + + +++P LR +L+DD++ V R + + P E ++ I+
Sbjct: 108 KGKKAKSVTIAPVMTADDMKVELPKPLRKILIDDYDLVC--RYFINIVPHEYSVDQIIED 165
Query: 229 FYAD--TSNSTSSVVEQAQLSEFLQGIKL--------------YFNLSLGKLLLYRLERI 272
+ SN V+ + IK+ YFN++LG LLY+ ER
Sbjct: 166 YIKTIPVSNEQMRTVDDLLIEYEEADIKITNLALICTARGLVDYFNVTLGYQLLYKFERP 225
Query: 273 QYAELLKAHSEKQYTEI----------------YGIIHLLRLVTLLPEMMESSNVDDQTA 316
QY +L+K + ++ +I YGI+H LR++ LP+ ++ + +D
Sbjct: 226 QYNDLVKKRAMEKGIDITNPTALQDSGFRPSQEYGIVHFLRMLAKLPDYLKLTQWNDHVI 285
Query: 317 -KILVKQCDILLEWIAINIARKNFPVDPYINTSSQYEGVA 355
+I++ D+++ KN Y SS Y+G +
Sbjct: 286 NRIMIGVHDLIV------FLNKNH--GKYYRGSSDYQGAS 317
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.135 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,545,091
Number of Sequences: 60738
Number of extensions: 714338
Number of successful extensions: 1979
Number of sequences better than 1.0e-05: 9
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1953
Number of HSP's gapped (non-prelim): 18
length of query: 358
length of database: 30,389,216
effective HSP length: 107
effective length of query: 251
effective length of database: 23,890,250
effective search space: 5996452750
effective search space used: 5996452750
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)