ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV3528 check: MH I KOG1206 Lipid transport and metabolism Peroxisomal multifunctional beta-oxidation protein and related enzymes
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV3528 1219430 1222096 889
(889 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 1231 0.0
7293189 [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 357 6e-98
CE01215 [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 163 1e-39
At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP... 130 1e-29
At1g76150 [I] KOG1206 Peroxisomal multifunctional beta-oxidation... 120 1e-26
7290108 [R] KOG0725 Reductases with broad range of substrate spe... 114 7e-25
CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 113 1e-24
CE04339 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 107 8e-23
CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 102 3e-21
Hs15277342 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 101 4e-21
At1g63380 [R] KOG0725 Reductases with broad range of substrate s... 101 6e-21
At3g51680 [R] KOG0725 Reductases with broad range of substrate s... 100 8e-21
Hs10047132 [R] KOG0725 Reductases with broad range of substrate ... 100 1e-20
Hs14754051 [R] KOG0725 Reductases with broad range of substrate ... 97 8e-20
CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 97 1e-19
At1g62610 [R] KOG0725 Reductases with broad range of substrate s... 96 3e-19
At1g52340 [R] KOG0725 Reductases with broad range of substrate s... 95 4e-19
7290386 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 95 5e-19
SPAC922.06 [R] KOG0725 Reductases with broad range of substrate ... 94 9e-19
7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 94 9e-19
Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 92 3e-18
At3g26770 [R] KOG0725 Reductases with broad range of substrate s... 92 3e-18
At3g46170 [R] KOG0725 Reductases with broad range of substrate s... 92 4e-18
At3g26760 [R] KOG0725 Reductases with broad range of substrate s... 91 6e-18
At4g03140 [R] KOG0725 Reductases with broad range of substrate s... 91 8e-18
7296705 [R] KOG0725 Reductases with broad range of substrate spe... 91 8e-18
At3g05260 [R] KOG0725 Reductases with broad range of substrate s... 91 1e-17
CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 90 2e-17
At3g55310 [R] KOG0725 Reductases with broad range of substrate s... 90 2e-17
At2g47120 [R] KOG0725 Reductases with broad range of substrate s... 90 2e-17
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 89 2e-17
7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 89 3e-17
At5g50690 [Q] KOG1205 Predicted dehydrogenase 89 4e-17
At5g50590 [Q] KOG1205 Predicted dehydrogenase 89 4e-17
CE21092 [R] KOG0725 Reductases with broad range of substrate spe... 86 2e-16
Hs10337605 [R] KOG0725 Reductases with broad range of substrate ... 86 3e-16
At3g03330 [Q] KOG1205 Predicted dehydrogenase 86 3e-16
At2g29340 [R] KOG0725 Reductases with broad range of substrate s... 86 3e-16
At1g07440 [R] KOG0725 Reductases with broad range of substrate s... 86 3e-16
At3g42960 [R] KOG0725 Reductases with broad range of substrate s... 85 4e-16
CE21093 [R] KOG0725 Reductases with broad range of substrate spe... 85 6e-16
CE19894 [R] KOG0725 Reductases with broad range of substrate spe... 85 6e-16
CE06649 [R] KOG0725 Reductases with broad range of substrate spe... 85 6e-16
Hs20373187 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 84 7e-16
Hs20149619 [Q] KOG1205 Predicted dehydrogenase 84 7e-16
At2g47130 [R] KOG0725 Reductases with broad range of substrate s... 84 7e-16
At1g54870 [R] KOG0725 Reductases with broad range of substrate s... 84 7e-16
At5g50700 [Q] KOG1205 Predicted dehydrogenase 84 1e-15
At5g50600 [Q] KOG1205 Predicted dehydrogenase 84 1e-15
Hs7705907 [R] KOG0725 Reductases with broad range of substrate s... 83 2e-15
Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 83 2e-15
7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 83 2e-15
Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydrox... 82 3e-15
At2g29330 [R] KOG0725 Reductases with broad range of substrate s... 82 4e-15
At2g29320 [R] KOG0725 Reductases with broad range of substrate s... 82 4e-15
CE27260 [R] KOG0725 Reductases with broad range of substrate spe... 82 5e-15
At3g47350 [Q] KOG1205 Predicted dehydrogenase 82 5e-15
At2g29300 [R] KOG0725 Reductases with broad range of substrate s... 82 5e-15
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 81 6e-15
Hs7706318 [Q] KOG1205 Predicted dehydrogenase 81 8e-15
SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate ... 80 1e-14
Hs10190704 [R] KOG0725 Reductases with broad range of substrate ... 80 1e-14
CE12990 [R] KOG0725 Reductases with broad range of substrate spe... 80 1e-14
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 80 2e-14
CE09969 [R] KOG0725 Reductases with broad range of substrate spe... 80 2e-14
At3g29260 [R] KOG0725 Reductases with broad range of substrate s... 80 2e-14
At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 80 2e-14
At2g30670 [R] KOG0725 Reductases with broad range of substrate s... 80 2e-14
CE05726 [R] KOG0725 Reductases with broad range of substrate spe... 79 2e-14
At5g06060 [R] KOG0725 Reductases with broad range of substrate s... 79 2e-14
7295487 [R] KOG0725 Reductases with broad range of substrate spe... 79 2e-14
Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 79 3e-14
CE27259 [R] KOG0725 Reductases with broad range of substrate spe... 79 3e-14
At2g29260 [R] KOG0725 Reductases with broad range of substrate s... 79 3e-14
Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 79 4e-14
Hs7657478 [Q] KOG1205 Predicted dehydrogenase 79 4e-14
CE21095 [R] KOG0725 Reductases with broad range of substrate spe... 79 4e-14
At2g29310 [R] KOG0725 Reductases with broad range of substrate s... 79 4e-14
7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 79 4e-14
At3g47360 [Q] KOG1205 Predicted dehydrogenase 78 5e-14
At3g29250 [R] KOG0725 Reductases with broad range of substrate s... 78 7e-14
7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 78 7e-14
At2g47140 [R] KOG0725 Reductases with broad range of substrate s... 77 9e-14
7301818 [Q] KOG1205 Predicted dehydrogenase 77 9e-14
7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase 77 9e-14
7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 77 9e-14
Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and... 77 1e-13
CE05427 [R] KOG0725 Reductases with broad range of substrate spe... 77 1e-13
At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase 77 2e-13
CE26808_2 [R] KOG0725 Reductases with broad range of substrate s... 77 2e-13
At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase a... 77 2e-13
SPAC22A12.17c [R] KOG0725 Reductases with broad range of substra... 76 2e-13
CE20725 [R] KOG0725 Reductases with broad range of substrate spe... 76 2e-13
CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 76 2e-13
Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 76 3e-13
Hs19923817 [R] KOG0725 Reductases with broad range of substrate ... 76 3e-13
CE15574 [R] KOG0725 Reductases with broad range of substrate spe... 76 3e-13
SPAC8E11.10 [R] KOG0725 Reductases with broad range of substrate... 75 3e-13
CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 75 3e-13
At2g29150 [R] KOG0725 Reductases with broad range of substrate s... 75 3e-13
At5g50770 [Q] KOG1205 Predicted dehydrogenase 75 4e-13
7296706_2 [R] KOG0725 Reductases with broad range of substrate s... 75 4e-13
Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase 75 6e-13
7296704 [R] KOG0725 Reductases with broad range of substrate spe... 75 6e-13
CE02490_1 [R] KOG0725 Reductases with broad range of substrate s... 75 6e-13
Hs5031737 [R] KOG0725 Reductases with broad range of substrate s... 74 1e-12
CE12594 [R] KOG0725 Reductases with broad range of substrate spe... 74 1e-12
CE03951 [R] KOG0725 Reductases with broad range of substrate spe... 74 1e-12
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 73 2e-12
CE13008 [R] KOG0725 Reductases with broad range of substrate spe... 72 3e-12
CE03954 [R] KOG0725 Reductases with broad range of substrate spe... 72 3e-12
CE03132 [R] KOG0725 Reductases with broad range of substrate spe... 72 5e-12
At2g29370 [R] KOG0725 Reductases with broad range of substrate s... 72 5e-12
At1g10310 [R] KOG0725 Reductases with broad range of substrate s... 72 5e-12
YNL202w [R] KOG0725 Reductases with broad range of substrate spe... 71 6e-12
SPAC977.08 [Q] KOG1205 Predicted dehydrogenase 71 6e-12
SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase 71 6e-12
At5g18210 [R] KOG0725 Reductases with broad range of substrate s... 71 6e-12
At4g10020 [Q] KOG1205 Predicted dehydrogenase 70 1e-11
7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 70 1e-11
7301617_1 [R] KOG0725 Reductases with broad range of substrate s... 70 2e-11
At2g29350 [R] KOG0725 Reductases with broad range of substrate s... 69 2e-11
CE10908 [R] KOG0725 Reductases with broad range of substrate spe... 69 3e-11
At2g29360 [R] KOG0725 Reductases with broad range of substrate s... 69 4e-11
At1g07450 [R] KOG0725 Reductases with broad range of substrate s... 69 4e-11
7296047 [Q] KOG1205 Predicted dehydrogenase 68 5e-11
YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 68 7e-11
At3g03980 [R] KOG0725 Reductases with broad range of substrate s... 68 7e-11
At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductas... 67 9e-11
SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate ... 67 1e-10
CE13054 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 67 1e-10
At2g29290 [R] KOG0725 Reductases with broad range of substrate s... 67 1e-10
At2g29170 [R] KOG0725 Reductases with broad range of substrate s... 67 1e-10
YMR226c [Q] KOG1205 Predicted dehydrogenase 66 3e-10
CE14538 [R] KOG0725 Reductases with broad range of substrate spe... 66 3e-10
At3g04000 [R] KOG0725 Reductases with broad range of substrate s... 66 3e-10
7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 66 3e-10
Hs4759084 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 65 4e-10
7295622 [Q] KOG1205 Predicted dehydrogenase 65 5e-10
CE07544 [Q] KOG1205 Predicted dehydrogenase 65 6e-10
7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 64 8e-10
YIR035c [Q] KOG1204 Predicted dehydrogenase 64 1e-09
At4g13180 [R] KOG0725 Reductases with broad range of substrate s... 64 1e-09
7297912 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 64 1e-09
7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 63 2e-09
SPCC1739.08c [R] KOG0725 Reductases with broad range of substrat... 62 3e-09
SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase 62 4e-09
HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 62 4e-09
Hs4503301 [R] KOG0725 Reductases with broad range of substrate s... 62 4e-09
At4g05530 [R] KOG0725 Reductases with broad range of substrate s... 62 5e-09
Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 60 1e-08
CE02315 [R] KOG0725 Reductases with broad range of substrate spe... 60 1e-08
7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 60 1e-08
Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 60 2e-08
CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 60 2e-08
SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reduct... 59 3e-08
CE02370 [R] KOG0725 Reductases with broad range of substrate spe... 59 3e-08
YIR036c [Q] KOG1204 Predicted dehydrogenase 59 4e-08
CE21514 [R] KOG0725 Reductases with broad range of substrate spe... 59 4e-08
SPCC162.03 [Q] KOG1205 Predicted dehydrogenase 58 6e-08
Hs5031765 [Q] KOG1205 Predicted dehydrogenase 58 7e-08
Hs10190746 [Q] KOG1208 Dehydrogenases with different specificiti... 58 7e-08
7300387 [Q] KOG1208 Dehydrogenases with different specificities ... 58 7e-08
Hs7705925 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 57 1e-07
Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 57 1e-07
Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 57 1e-07
CE11498 [R] KOG0725 Reductases with broad range of substrate spe... 57 1e-07
7292613 [Q] KOG1205 Predicted dehydrogenase 57 1e-07
7295621 [Q] KOG1205 Predicted dehydrogenase 57 2e-07
CE07539 [Q] KOG1205 Predicted dehydrogenase 56 2e-07
SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase 56 3e-07
SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase 56 3e-07
Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 56 3e-07
Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 55 5e-07
Hs20070272 [Q] KOG1208 Dehydrogenases with different specificiti... 55 5e-07
Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 55 5e-07
CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 55 5e-07
Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase 55 5e-07
7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 55 6e-07
ECU08g1150 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 54 8e-07
YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 54 1e-06
7304181 [Q] KOG1208 Dehydrogenases with different specificities ... 54 1e-06
At1g01800 [Q] KOG1208 Dehydrogenases with different specificitie... 54 1e-06
SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase 53 2e-06
SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 53 2e-06
CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 53 2e-06
Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 52 3e-06
7302393 [Q] KOG1208 Dehydrogenases with different specificities ... 52 3e-06
7298167 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 52 3e-06
Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 52 4e-06
7304177 [Q] KOG1208 Dehydrogenases with different specificities ... 52 4e-06
7290709 [Q] KOG1208 Dehydrogenases with different specificities ... 52 4e-06
At5g53090 [Q] KOG1208 Dehydrogenases with different specificitie... 51 7e-06
7294121 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 51 7e-06
>YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 900
Score = 1231 bits (3184), Expect = 0.0
Identities = 617/901 (68%), Positives = 732/901 (80%), Gaps = 17/901 (1%)
Query: 2 SLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRS---------AADSVVQEIK 52
+L FKDRVV+ITGAGGGLG+VYAL YA RG KVVVNDLG + AAD VV EIK
Sbjct: 4 NLSFKDRVVVITGAGGGLGKVYALAYASRGAKVVVNDLGGTLGGSGHNSKAADLVVDEIK 63
Query: 53 KLGGEGDAVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVI 112
K GG AVANYDSV++NG I+ETAI FGRVD+LINNAGILRD SFAKM+E++F V+
Sbjct: 64 KAGGI--AVANYDSVNENGEKIIETAIKEFGRVDVLINNAGILRDVSFAKMTEREFASVV 121
Query: 113 DVHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAK 172
DVHL G +KL+RAAWP+MR QKFGRIINT SPAGL+GNFGQANYSAAK+GL+G E+LAK
Sbjct: 122 DVHLTGGYKLSRAAWPYMRSQKFGRIINTASPAGLFGNFGQANYSAAKMGLVGLAETLAK 181
Query: 173 EGYKYNINVNSIAPLARSAMTENVIPANILKELGPEKIAPLILYLTHENTKVTNNIFELA 232
EG KYNINVNSIAPLARS MTENV+P +ILK+LGPEKI PL+LYLTHE+TKV+N+IFELA
Sbjct: 182 EGAKYNINVNSIAPLARSRMTENVLPPHILKQLGPEKIVPLVLYLTHESTKVSNSIFELA 241
Query: 233 AGFYSQIRWERSSGELFHPNVETLTPETILPKFNKIIEFKDKPFNKVQHPIELSNYNDLI 292
AGF+ Q+RWERSSG++F+P+ +T TPE IL K+ +I +++DKPFNK QHP +LS+YNDLI
Sbjct: 242 AGFFGQLRWERSSGQIFNPDPKTYTPEAILNKWKEITDYRDKPFNKTQHPYQLSDYNDLI 301
Query: 293 TKARELPENKNGPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVV 352
TKA++LP N+ G + IKSL KVV++TG+G GLGKSHA WFARYGAKVV+NDI+DP +VV
Sbjct: 302 TKAKKLPPNEQGSVKIKSLCNKVVVVTGAGGGLGKSHAIWFARYGAKVVVNDIKDPFSVV 361
Query: 353 DEINKKYGSGSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEW 412
+EINK YG G+A+ D+HD+V EA ++QTA+ KF RVDILVNNAGILRD+SF KM ++EW
Sbjct: 362 EEINKLYGEGTAIPDSHDVVTEAPLIIQTAISKFQRVDILVNNAGILRDKSFLKMKDEEW 421
Query: 413 NAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSR 472
AV+ VHLFSTF+LSKAVWPIF KQKSG+IINTTSTSGIYGNFGQ NYAAAKAAILGFS+
Sbjct: 422 FAVLKVHLFSTFSLSKAVWPIFTKQKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSK 481
Query: 473 TLALEGTKRGITVNVIAPHAETAMTKTIFSSKELNNHFDPGFVSPFVVLLCSDELQELGK 532
T+ALEG KRGI VNVIAPHAETAMTKTIFS KEL+NHFD VSP VVLL S+ELQ+
Sbjct: 482 TIALEGAKRGIIVNVIAPHAETAMTKTIFSEKELSNHFDASQVSPLVVLLASEELQKYSG 541
Query: 533 NRVKGLLFEVGGGWCGLTRWQRSRGIVNSDAT--PEYLAEHWKELTDFSKGTMNPSSTQE 590
RV G LFEVGGGWCG TRWQRS G V+ T PE + E+W +TDFS+ T+NPSST+E
Sbjct: 542 RRVIGQLFEVGGGWCGQTRWQRSSGYVSIKETIEPEEIKENWNHITDFSRNTINPSSTEE 601
Query: 591 SSMAILQSVHK-HAADKAKPKTYKYTSRDVILYNLGLGATTRELQYTYENHPQFQVLPTF 649
SSMA LQ+V K H++ + +KYT++D ILYNLGLG T++EL+YTYEN P FQVLPTF
Sbjct: 602 SSMATLQAVQKAHSSKELDDGLFKYTTKDCILYNLGLGCTSKELKYTYENDPDFQVLPTF 661
Query: 650 ATIPYMADGSIDIKFDELVDNFNYAMLLHGEQYFKINKFPLPTSGELRTTGKPLQVLGKS 709
A IP+M + + D LVDNFNYAMLLHGEQYFK+ +P++G L+T KPLQVL K+
Sbjct: 662 AVIPFM-QATATLAMDNLVDNFNYAMLLHGEQYFKLCTPTMPSNGTLKTLAKPLQVLDKN 720
Query: 710 SKAAIIVGGYETVDAKTNEPVIYNEGTFFVRNAVVPDNKVINKAKERSPFATKAFVTKDL 769
KAA++VGG+ET D KT + + YNEG+FF+R A VP K + K R+ FA + F
Sbjct: 721 GKAALVVGGFETYDIKTKKLIAYNEGSFFIRGAHVPPEKEVRDGK-RAKFAVQNFEVPHG 779
Query: 770 GDPDFEAEISTFEDQAALYRLSGDYNPLHIDPQLAKSVKFPKPILHGLCTLGVSAKELFE 829
PDFEAEIST +DQAALYRLSGD+NPLHIDP LAK+VKFP PILHGLCTLG+SAK LFE
Sbjct: 780 KVPDFEAEISTNKDQAALYRLSGDFNPLHIDPTLAKAVKFPTPILHGLCTLGISAKALFE 839
Query: 830 KYGPFDELKARFTNVVFPGDRLKVKAWKKNDVVIFQTTDLNTGKIVLDNSAIKLI-GKSK 888
YGP++ELK RFTNVVFPGD LKVKAWK+ VV+FQT D IVLDN+A+KL KSK
Sbjct: 840 HYGPYEELKVRFTNVVFPGDTLKVKAWKQGSVVVFQTIDTTRNVIVLDNAAVKLSQAKSK 899
Query: 889 L 889
L
Sbjct: 900 L 900
>7293189 [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 598
Score = 357 bits (915), Expect = 6e-98
Identities = 226/601 (37%), Positives = 326/601 (53%), Gaps = 51/601 (8%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDI-----------RDPSAVVDEINKKYGS 361
G+V ++TG+G+GLG+ +A FA GAKVV+ND+ R VVDEI K
Sbjct: 12 GRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRK--AG 69
Query: 362 GSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
G AVAD + ++ A+ V++TA+ FGRVDILVNNAGILRDRS K +E +WN V +VHL
Sbjct: 70 GEAVADYNSVIDGAK-VIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLK 128
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
+F ++A +P KQ G II T+S SGIYGNFGQ NY AAK ++G + T+A+EG +
Sbjct: 129 GSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARN 188
Query: 482 GITVNVIAPHAETAMTKTIFSSKELNNHFDPGFVSPFVVLLCSDELQELGKNRVKGLLFE 541
+ NVI P A + MT+ I L N P ++P V LC + ++ G E
Sbjct: 189 NVLCNVIVPTAASRMTEGILPD-ILFNELKPKLIAPVVAYLCHESCED------NGSYIE 241
Query: 542 VGGGWCGLTRWQRSRGIV-----NSDATPEYLAEHWKELTDFSKGTMNPSSTQESSMAIL 596
GW R +G V + T EY+ + W +TD SK + + E+S +L
Sbjct: 242 SAAGWATKLHMVRGKGAVLRPSLDDPVTIEYVKDVWSNVTDMSK-AKHLGAIAEASGTLL 300
Query: 597 QSVH--KHAADKAKPKTYKYTSRDVILYNLGLGAT---TRELQYTYENHPQFQVLPTFAT 651
+ + K A +++ S+++I Y LG+GA+ +++++ YEN F +PTF
Sbjct: 301 EVLEKLKEGGGDAIEDAFEFNSKELITYALGIGASVKNAKDMRFLYENDADFAAIPTFFV 360
Query: 652 IP-YMADGSIDIKFDELVDN--FNYAMLLHGEQYFKINKFPLPTSGELRTTGKPLQVLGK 708
+P + S D + + N +++ +LHGEQY +I LPTSG L T GK V+ K
Sbjct: 361 LPGLLLQMSTDKLLSKALPNSQVDFSNILHGEQYLEIVD-DLPTSGTLLTNGKVFDVMDK 419
Query: 709 SSKAAIIVGGYETVDAKTNEPVIYNEGTFFVRNAVVPDNKVINKAKERSPFA-TKAFVTK 767
S A++V E+ D ++ ++ N+ T F+ A K + P A
Sbjct: 420 GS-GAVVVTNSESFD-ESGRLLVRNQSTTFIVGAGKFGGK-------KDPIAGVVPLQPA 470
Query: 768 DLGDPDFEAEISTFEDQAALYRLSGDYNPLHIDPQLAKSVKFPKPILHGLCTLGVSAKEL 827
PD + +T EDQAALYRLSGD NPLHIDPQ+A F PILHGLCTLG S + +
Sbjct: 471 PNRQPDATVQYTTSEDQAALYRLSGDKNPLHIDPQMALLAGFKTPILHGLCTLGFSVRAV 530
Query: 828 FEKYGP-----FDELKARFTNVVFPGDRLKVKAWKKNDVVIFQTTDLNTGKIVLDNSAIK 882
++ F +K RF+ V PG L+V WK+ + F+T + TGK V+ + +
Sbjct: 531 LAQFADNNPALFKAVKVRFSGPVIPGQTLRVDLWKQGTRINFRTVVVETGKEVISGAYVD 590
Query: 883 L 883
L
Sbjct: 591 L 591
Score = 253 bits (647), Expect = 7e-67
Identities = 134/261 (51%), Positives = 180/261 (68%), Gaps = 12/261 (4%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLG---------RSAADSVVQEIKK 53
L + RV ++TGAG GLGR YAL +A+RG KVVVNDLG + AAD VV EI+K
Sbjct: 8 LRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRK 67
Query: 54 LGGEGDAVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVID 113
GGE AVA+Y+SV D GA ++ETAI FGRVDIL+NNAGILRD S K SE+ + V D
Sbjct: 68 AGGE--AVADYNSVID-GAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVND 124
Query: 114 VHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
VHL G+FK T+AA+P+M+KQ +GRII T S +G+YGNFGQ NY+AAK+GL+G ++A E
Sbjct: 125 VHLKGSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIE 184
Query: 174 GYKYNINVNSIAPLARSAMTENVIPANILKELGPEKIAPLILYLTHENTKVTNNIFELAA 233
G + N+ N I P A S MTE ++P + EL P+ IAP++ YL HE+ + + E AA
Sbjct: 185 GARNNVLCNVIVPTAASRMTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAA 244
Query: 234 GFYSQIRWERSSGELFHPNVE 254
G+ +++ R G + P+++
Sbjct: 245 GWATKLHMVRGKGAVLRPSLD 265
>CE01215 [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 298
Score = 163 bits (413), Expect = 1e-39
Identities = 109/294 (37%), Positives = 154/294 (52%), Gaps = 22/294 (7%)
Query: 604 ADKAKPKTYKYTSRDVILYNLGLGATTRE-LQYTYENHPQFQVLPTFATIP-YMADGSID 661
A A+P + Y++RD I+Y LG+GA +E L Y YENH F+VLP++ P + A +D
Sbjct: 8 AHVAEPCEFSYSTRDAIIYALGVGARAKEDLCYVYENHEDFKVLPSYIVAPGFQAHTLMD 67
Query: 662 IKFDELVDNFNYAMLLHGEQYFKINKFPLPTSGELRTTGKPLQVLGKSSKAAIIVGGYET 721
E F+ +LHGEQY ++ + PL G+L++ + + +L K S A+I+G T
Sbjct: 68 WPGVE----FDLQRVLHGEQYIEVYQ-PLSAEGKLKSEARVVDILDKGS-GALILGNVTT 121
Query: 722 VDAKTNEPVIYNEGTFFVRNAVVPDNKVINKAKERSPFATKAFVTKDLGDPDFEAEISTF 781
D + + TF + ++ SP KA D PD E T
Sbjct: 122 YDENGKKIAMQQFSTFQTGSGNFGGDRT-------SPHEIKAATVPDRA-PDAVIEQKTT 173
Query: 782 EDQAALYRL-SGDYNPLHIDPQLAKSVKFPKPILHGLCTLGVSAKELFEKYG-----PFD 835
DQAALYRL SGD NPLH+DP+ AK F PILHGLC+LG + + + + F
Sbjct: 174 VDQAALYRLGSGDMNPLHVDPEFAKMSGFKTPILHGLCSLGFATRHVIAAWAGNDSDKFK 233
Query: 836 ELKARFTNVVFPGDRLKVKAWKKNDVVIFQTTDLNTGKIVLDNSAIKLIGKSKL 889
+K RF++ V PG L + WK +IFQ TGKIV+ N+ I L S+L
Sbjct: 234 AIKVRFSSPVLPGQTLVTETWKNGKRIIFQMKVKETGKIVISNAFIDLHEASEL 287
>At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 308
Score = 130 bits (326), Expect = 1e-29
Identities = 74/180 (41%), Positives = 110/180 (61%), Gaps = 14/180 (7%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSA--ADSVVQEIKKLGGEGDAVANYDS 66
VV+ITGA G+G+ AL K G KV+VN RSA A+ V ++I++ GG+ S
Sbjct: 78 VVVITGASRGIGKAIALALGKAGCKVLVN-YARSAKEAEEVAKQIEEYGGQAITFGGDVS 136
Query: 67 VSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAA 126
+ + A+++TA+ +G +D+++NNAGI RD+ +M + Q+ +VI ++L G F T+
Sbjct: 137 KATDVDAMMKTALDKWGTIDVVVNNAGITRDTLLIRMKQSQWDEVIALNLTGVFLCTQ-- 194
Query: 127 WPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
GRIIN S GL GN GQANY+AAK G++ F ++ A+EG NINVN + P
Sbjct: 195 ---------GRIINISSVVGLIGNIGQANYAAAKGGVISFSKTAAREGASRNINVNVVCP 245
Score = 123 bits (309), Expect = 1e-27
Identities = 72/208 (34%), Positives = 116/208 (55%), Gaps = 18/208 (8%)
Query: 288 YNDLITKARELPENKNGPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRD 347
++ + KA+ ++ ++ + VV+ITG+ G+GK+ A + G KV++N R
Sbjct: 51 FSTSVVKAQATATEQSPGEVVQKVESPVVVITGASRGIGKAIALALGKAGCKVLVNYARS 110
Query: 348 PSAVVDEINKK---YGSGSAVADTHDIVK--EAQQVVQTAVDKFGRVDILVNNAGILRDR 402
+E+ K+ YG G A+ D+ K + +++TA+DK+G +D++VNNAGI RD
Sbjct: 111 AKEA-EEVAKQIEEYG-GQAITFGGDVSKATDVDAMMKTALDKWGTIDVVVNNAGITRDT 168
Query: 403 SFAKMTEDEWNAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAA 462
+M + +W+ VI ++L F ++ G IIN +S G+ GN GQ NYAA
Sbjct: 169 LLIRMKQSQWDEVIALNLTGVFLCTQ-----------GRIINISSVVGLIGNIGQANYAA 217
Query: 463 AKAAILGFSRTLALEGTKRGITVNVIAP 490
AK ++ FS+T A EG R I VNV+ P
Sbjct: 218 AKGGVISFSKTAAREGASRNINVNVVCP 245
>At1g76150 [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 312
Score = 120 bits (300), Expect = 1e-26
Identities = 96/273 (35%), Positives = 135/273 (49%), Gaps = 29/273 (10%)
Query: 618 DVILYNLGLGATTR------ELQYTYENHPQ--FQVLPTFATIPYMADGSIDIKFDELVD 669
DV +Y LG+GA + EL++ Y + Q QVLPTFA++ + GS+ D
Sbjct: 42 DVAIYALGIGACGQDAVDSDELKFVYHRNGQDLIQVLPTFASLFTL--GSLTEGLDLPGF 99
Query: 670 NFNYAMLLHGEQYFKINKFPLPTSGELRTTGKPLQVLGKSSKAAIIVGGYETVDAKTNEP 729
++ ++LLHG+QY +I + PLP+ L L L KAAI+ + + + E
Sbjct: 100 KYDPSLLLHGQQYIEIYR-PLPSKASL-INKVSLAGLQDKGKAAILELETRSYEEGSGEL 157
Query: 730 VIYNEGTFFVRNAVVPDNKVINKAKERSPFATKAFVTKDLGDPDFEAEISTFEDQAAL-Y 788
+ N T F+R A N PF+ K + + +I + AL Y
Sbjct: 158 LCMNRTTVFLRGAGGFSNS-------SQPFSYKNYPSNQ----GLAVKIPQRQPLTALLY 206
Query: 789 RLSGDYNPLHIDPQLAKSVKFPKPILHGLCTLGVSAKELFE---KYGP--FDELKARFTN 843
RLSGDYNPLH DP+ AK FP+PILHGLCTLG + K + + K P + RF
Sbjct: 207 RLSGDYNPLHSDPEFAKLAGFPRPILHGLCTLGFAIKAIIKCVCKGDPTAVKTISGRFLT 266
Query: 844 VVFPGDRLKVKAWKKNDVVIFQTTDLNTGKIVL 876
VFPG+ L + W + VI+QT K VL
Sbjct: 267 TVFPGETLITEMWLEGLRVIYQTKVKERNKTVL 299
>7290108 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 114 bits (285), Expect = 7e-25
Identities = 69/181 (38%), Positives = 104/181 (57%), Gaps = 3/181 (1%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTH 369
SL KVVI+TG+ SG+G + AQ AR GA + + + A ++ K A
Sbjct: 2 SLSNKVVIVTGASSGIGAAIAQVLAREGATLAL--VGRNVANLEATKKSLKGTQAEIVVA 59
Query: 370 DIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKA 429
D+ K+A +VQ + KFGR+D+LVNNAGIL + +E++AV+N +L L+KA
Sbjct: 60 DVTKDADAIVQQTLAKFGRIDVLVNNAGILGKGGLIDLDIEEFDAVLNTNLRGVILLTKA 119
Query: 430 VWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVIA 489
V P LK K G ++N +S +GI G +Y +KAA+ F++ +ALE +G+ VN +
Sbjct: 120 VLPHLLKTK-GAVVNVSSCAGIRPFAGALSYGVSKAALDQFTKIVALEMAPQGVRVNSVN 178
Query: 490 P 490
P
Sbjct: 179 P 179
Score = 97.4 bits (241), Expect = 8e-20
Identities = 58/184 (31%), Positives = 97/184 (52%), Gaps = 5/184 (2%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVA 62
+ ++VVI+TGA G+G A A+ G + + +GR+ A+ + G + + V
Sbjct: 1 MSLSNKVVIVTGASSGIGAAIAQVLAREGATLAL--VGRNVANLEATKKSLKGTQAEIVV 58
Query: 63 NYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKL 122
V+ + AIV+ ++ FGR+D+L+NNAGIL + ++F V++ +L G L
Sbjct: 59 A--DVTKDADAIVQQTLAKFGRIDVLVNNAGILGKGGLIDLDIEEFDAVLNTNLRGVILL 116
Query: 123 TRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVN 182
T+A PH+ K K G ++N S AG+ G +Y +K L F + +A E + VN
Sbjct: 117 TKAVLPHLLKTK-GAVVNVSSCAGIRPFAGALSYGVSKAALDQFTKIVALEMAPQGVRVN 175
Query: 183 SIAP 186
S+ P
Sbjct: 176 SVNP 179
>CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 296
Score = 113 bits (283), Expect = 1e-24
Identities = 80/247 (32%), Positives = 130/247 (52%), Gaps = 18/247 (7%)
Query: 2 SLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAV 61
S ++ I+TG G G+G+ ++A G +++V DL +SAA++ L G G +
Sbjct: 51 STMLSSKLAIVTGGGSGIGQAICKKFAASGARLIVADLKKSAAEATAGN---LPGNGHSA 107
Query: 62 ANYDSVSDNGAAIVETAISNFGRV-DILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
D A ++ I + G +L+N AGI +D++ KMS+ Q+Q V++V+LN F
Sbjct: 108 FEIDVSDPEHVARLQEFIKSSGESPSVLVNCAGITKDATLLKMSQNQWQDVMNVNLNSVF 167
Query: 121 KLTRA-AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNI 179
+++ A + I+N S G GNFGQ NY+A K G++GF +S A+E NI
Sbjct: 168 LMSQMIARESVAAGSPLSIVNVSSIVGKIGNFGQTNYAATKSGVIGFTKSAARELATKNI 227
Query: 180 NVNSIAP-LARSAMTENVIPANIL---------KELG-PEKIAPLILYLTHE-NTKVTNN 227
VN++ P R+ MTE +P +L + LG E+IA +L+L + ++ VT
Sbjct: 228 RVNAVLPGFIRTPMTE-AMPPKVLDAMVSMVPQRRLGETEEIANAVLFLASDMSSYVTGT 286
Query: 228 IFELAAG 234
E+ G
Sbjct: 287 TLEVTGG 293
Score = 102 bits (254), Expect = 3e-21
Identities = 64/196 (32%), Positives = 111/196 (55%), Gaps = 10/196 (5%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSA----VA 366
L K+ I+TG GSG+G++ + FA GA++++ D++ +A N SA V+
Sbjct: 54 LSSKLAIVTGGGSGIGQAICKKFAASGARLIVADLKKSAAEATAGNLPGNGHSAFEIDVS 113
Query: 367 DTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFAL 426
D + + Q+ ++++ + +LVN AGI +D + KM++++W V+NV+L S F +
Sbjct: 114 DPEHVAR-LQEFIKSSGES---PSVLVNCAGITKDATLLKMSQNQWQDVMNVNLNSVFLM 169
Query: 427 SKAVWPIFLKQKSGY-IINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
S+ + + S I+N +S G GNFGQ NYAA K+ ++GF+++ A E + I V
Sbjct: 170 SQMIARESVAAGSPLSIVNVSSIVGKIGNFGQTNYAATKSGVIGFTKSAARELATKNIRV 229
Query: 486 NVIAP-HAETAMTKTI 500
N + P T MT+ +
Sbjct: 230 NAVLPGFIRTPMTEAM 245
>CE04339 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 255
Score = 107 bits (267), Expect = 8e-23
Identities = 80/241 (33%), Positives = 120/241 (49%), Gaps = 25/241 (10%)
Query: 13 TGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA---VANYDSVSD 69
+G G+G+ + AK G +VVV DL A + + + V+N DSV
Sbjct: 20 SGGASGIGKAISQTLAKHGARVVVADLDSGNAAATAKALPASQSHSSFACDVSNADSVKG 79
Query: 70 NGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRA---A 126
+ + + G IL+N AGI +DS+ KM ++Q+ VI V+L G F +++A A
Sbjct: 80 -----LSEHVKSLGTPSILVNCAGITKDSTLLKMKQEQWDSVIKVNLTGVFHVSQAFVKA 134
Query: 127 WPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
IIN S G GNFGQ NY+A K G++GF +S AKE K N+ VN++ P
Sbjct: 135 SVDNNNHPLS-IINVSSIVGKMGNFGQTNYAATKAGVIGFTKSAAKELAKKNVRVNAVLP 193
Query: 187 -LARSAMTENVIPANILKEL----------GPEKIAPLILYLTHE-NTKVTNNIFELAAG 234
++ MTE +P +L E+ E+IA +LYL + ++ VT E+ G
Sbjct: 194 GFIKTPMTE-AMPPTVLAEICKGIPMGRMGEAEEIANSVLYLASDLSSYVTGATLEVTGG 252
Query: 235 F 235
F
Sbjct: 253 F 253
Score = 103 bits (258), Expect = 9e-22
Identities = 66/200 (33%), Positives = 109/200 (54%), Gaps = 11/200 (5%)
Query: 308 IKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDE----INKKYGSGS 363
+K + K +G SG+GK+ +Q A++GA+VV+ D+ +A ++ + S +
Sbjct: 9 VKRAKTKKSQFSGGASGIGKAISQTLAKHGARVVVADLDSGNAAATAKALPASQSHSSFA 68
Query: 364 AVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFST 423
D VK + V++ G ILVN AGI +D + KM +++W++VI V+L
Sbjct: 69 CDVSNADSVKGLSEHVKS----LGTPSILVNCAGITKDSTLLKMKQEQWDSVIKVNLTGV 124
Query: 424 FALSKAVWPIFLKQKSG--YIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
F +S+A + + IIN +S G GNFGQ NYAA KA ++GF+++ A E K+
Sbjct: 125 FHVSQAFVKASVDNNNHPLSIINVSSIVGKMGNFGQTNYAATKAGVIGFTKSAAKELAKK 184
Query: 482 GITVNVIAP-HAETAMTKTI 500
+ VN + P +T MT+ +
Sbjct: 185 NVRVNAVLPGFIKTPMTEAM 204
>CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 102 bits (254), Expect = 3e-21
Identities = 64/193 (33%), Positives = 104/193 (53%), Gaps = 9/193 (4%)
Query: 306 IPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAV 365
+P K L K V+ITG+G+GLGK AQ FA GA +++ DI S VDE+ +
Sbjct: 33 LPKKDLYRKKVLITGAGNGLGKLLAQKFAARGATLILWDINLQS--VDELKNEIRGNQGE 90
Query: 366 ADTHDI----VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
A ++++ + QV Q ++ G+VDILVNNAGI + +E+E N +V++
Sbjct: 91 AHSYEVNLCDPGKIAQVGQQVINDIGKVDILVNNAGIATAKMILDSSENEINRSFDVNVK 150
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLA---LEG 478
+ F + P LK +G+I+ S +G G+ G +Y++ K A +GF +L +E
Sbjct: 151 AHFYTVQQFLPAMLKDNNGHIVTIASAAGKMGSSGLADYSSTKHAAVGFHDSLVAEIMES 210
Query: 479 TKRGITVNVIAPH 491
K G+ ++ P+
Sbjct: 211 EKNGVKTTLVCPY 223
Score = 100 bits (248), Expect = 1e-20
Identities = 58/166 (34%), Positives = 92/166 (54%), Gaps = 4/166 (2%)
Query: 10 VIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSD 69
V+ITGAG GLG++ A ++A RG +++ D+ + D + EI+ G +G+A + ++ D
Sbjct: 43 VLITGAGNGLGKLLAQKFAARGATLILWDINLQSVDELKNEIR--GNQGEAHSYEVNLCD 100
Query: 70 NG--AAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAW 127
G A + + I++ G+VDIL+NNAGI SE + + DV++ F +
Sbjct: 101 PGKIAQVGQQVINDIGKVDILVNNAGIATAKMILDSSENEINRSFDVNVKAHFYTVQQFL 160
Query: 128 PHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
P M K G I+ S AG G+ G A+YS+ K +GF +SL E
Sbjct: 161 PAMLKDNNGHIVTIASAAGKMGSSGLADYSSTKHAAVGFHDSLVAE 206
>Hs15277342 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 261
Score = 101 bits (252), Expect = 4e-21
Identities = 76/252 (30%), Positives = 128/252 (50%), Gaps = 22/252 (8%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGE-----GDA 60
+ + ++TGAG G+GR ++ A G V DL R+AA V+ + G + G+
Sbjct: 10 RSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNH 69
Query: 61 VANYDSVSDNGAA--IVETAISNFGRV-DILINNAGILRDSSFAKMSEKQFQQVIDVHLN 117
A VS+ AA ++E + F R ++++ AGI +D MSE + +VI V+L
Sbjct: 70 AAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLK 129
Query: 118 GAFKLTRAAWPHMRKQKF-GRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYK 176
G F +T+AA + G IIN S G GN GQ NY+A+K G++G ++ A+E +
Sbjct: 130 GTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGR 189
Query: 177 YNINVNSIAP-LARSAMTENVIPANILKEL----------GPEKIAPLILYLTHENT-KV 224
+ I NS+ P + MT+ V P ++ ++ PE +A ++ +L E++ +
Sbjct: 190 HGIRCNSVLPGFIATPMTQKV-PQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYI 248
Query: 225 TNNIFELAAGFY 236
T E+ G +
Sbjct: 249 TGTSVEVTGGLF 260
Score = 90.1 bits (222), Expect = 1e-17
Identities = 78/257 (30%), Positives = 123/257 (47%), Gaps = 29/257 (11%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAV----- 365
LR + ++TG+GSG+G++ + A GA V D+ D +A + + G GS
Sbjct: 9 LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDL-DRAAAQETVRLLGGPGSKEGPPRG 67
Query: 366 ------ADTHDIVKEAQQVVQTAVDKFGRV-DILVNNAGILRDRSFAKMTEDEWNAVINV 418
AD + + A+ +++ F R ++V+ AGI +D M+ED+W+ VI V
Sbjct: 68 NHAAFQADVSE-ARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAV 126
Query: 419 HLFSTFALSKAVWPIFLKQKS-GYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
+L TF +++A + G IIN +S G GN GQ NYAA+KA ++G ++T A E
Sbjct: 127 NLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARE 186
Query: 478 GTKRGITVNVIAP-HAETAMTK--------TIFSSKELNNHFDPGFVSPFVVLLCSDELQ 528
+ GI N + P T MT+ I + + DP V+ V L S++
Sbjct: 187 LGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASED-- 244
Query: 529 ELGKNRVKGLLFEVGGG 545
+ G EV GG
Sbjct: 245 ---SGYITGTSVEVTGG 258
>At1g63380 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 287
Score = 101 bits (251), Expect = 6e-21
Identities = 82/254 (32%), Positives = 132/254 (51%), Gaps = 24/254 (9%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEG-DAVA 62
E KD+VV++TGA G+GR L+ K G K+V +S+ EI G G AVA
Sbjct: 21 ELKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAVA 80
Query: 63 ---NYDSVSDNGAAIVETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVHLNG 118
+ S +D V+ A FG++D+LINNAGI + S +SE+++ +V +L G
Sbjct: 81 LELDVSSEADTIRKAVKEAWETFGKIDVLINNAGIRGNVKSSLDLSEEEWDKVFRTNLTG 140
Query: 119 AFKLTRAAWPHMR-KQKFGRIINTCSPAGLYGNF--GQANYSAAKLGLLGFGESLAKEGY 175
++ +++ MR ++ G +IN S +GL+ G Y+ +K G+ +A E
Sbjct: 141 SWLISKYVCLLMRDAERGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELA 200
Query: 176 KYNINVNSIAP-LARSAMTENVIPANILKELGPEKIAP-------------LILYLTHEN 221
Y I VNSIAP + RS +T+ + LK++ EK+ P L+ YL H++
Sbjct: 201 VYKIRVNSIAPGIFRSEITQGLFQKEWLKKV-TEKVVPLKMQQTVDPGLTSLVRYLIHDS 259
Query: 222 TK-VTNNIFELAAG 234
++ VT N + + +G
Sbjct: 260 SQYVTGNTYIVDSG 273
Score = 85.5 bits (210), Expect = 3e-16
Identities = 63/194 (32%), Positives = 104/194 (53%), Gaps = 10/194 (5%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP--SAVVDEINKKYGSG-S 363
P L+ KVV++TG+ SG+G+ + G K+V R +++ EIN G
Sbjct: 18 PWCELKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQ 77
Query: 364 AVADTHDIVKEAQQV---VQTAVDKFGRVDILVNNAGILRD-RSFAKMTEDEWNAVINVH 419
AVA D+ EA + V+ A + FG++D+L+NNAGI + +S ++E+EW+ V +
Sbjct: 78 AVALELDVSSEADTIRKAVKEAWETFGKIDVLINNAGIRGNVKSSLDLSEEEWDKVFRTN 137
Query: 420 LFSTFALSKAVWPIFL-KQKSGYIINTTSTSGIYGNF--GQCNYAAAKAAILGFSRTLAL 476
L ++ +SK V + ++ G +IN +S SG++ G YA +K + +R +A+
Sbjct: 138 LTGSWLISKYVCLLMRDAERGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAI 197
Query: 477 EGTKRGITVNVIAP 490
E I VN IAP
Sbjct: 198 ELAVYKIRVNSIAP 211
>At3g51680 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 100 bits (250), Expect = 8e-21
Identities = 69/200 (34%), Positives = 104/200 (51%), Gaps = 9/200 (4%)
Query: 300 ENKNGPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRD--PSAVVDEINK 357
E N + K L GKV IITG G+GK+ FAR+GA VVI D+ + S++ ++
Sbjct: 21 EETNTTLYPKRLEGKVAIITGGAHGIGKATVMLFARHGATVVIADVDNVAGSSLAKSLSS 80
Query: 358 KYGSGSAVADTHDIVKEA--QQVVQTAVDKFGRVDILVNNAGILRD----RSFAKMTEDE 411
S + D+ EA + +V V ++GR+DIL NNAG+L D +S DE
Sbjct: 81 HKTSPMVAFISCDVSVEADVENLVNVTVARYGRLDILFNNAGVLGDQKKHKSILDFDADE 140
Query: 412 WNAVINVHLFST-FALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGF 470
++ V+ V++ + + + G II+T S +G+ G G Y A+K AI+G
Sbjct: 141 FDHVMRVNVRGVGLGMKHGARAMIKRGFKGCIISTASVAGVMGGMGPHAYTASKHAIVGL 200
Query: 471 SRTLALEGTKRGITVNVIAP 490
++ A E K GI VN I+P
Sbjct: 201 TKNAACELGKYGIRVNCISP 220
Score = 85.1 bits (209), Expect = 4e-16
Identities = 59/186 (31%), Positives = 94/186 (49%), Gaps = 7/186 (3%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIK--KLGGEGDAVANYD 65
+V IITG G+G+ + +A+ G VV+ D+ A S+ + + K ++
Sbjct: 35 KVAIITGGAHGIGKATVMLFARHGATVVIADVDNVAGSSLAKSLSSHKTSPMVAFISCDV 94
Query: 66 SVSDNGAAIVETAISNFGRVDILINNAGILRDS----SFAKMSEKQFQQVIDVHLNGAFK 121
SV + +V ++ +GR+DIL NNAG+L D S +F V+ V++ G
Sbjct: 95 SVEADVENLVNVTVARYGRLDILFNNAGVLGDQKKHKSILDFDADEFDHVMRVNVRGVGL 154
Query: 122 LTRAAWPHMRKQKF-GRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
+ M K+ F G II+T S AG+ G G Y+A+K ++G ++ A E KY I
Sbjct: 155 GMKHGARAMIKRGFKGCIISTASVAGVMGGMGPHAYTASKHAIVGLTKNAACELGKYGIR 214
Query: 181 VNSIAP 186
VN I+P
Sbjct: 215 VNCISP 220
>Hs10047132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 245
Score = 100 bits (249), Expect = 1e-20
Identities = 62/181 (34%), Positives = 104/181 (57%), Gaps = 8/181 (4%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
L GKV+I+T + G+G++ A FAR GAKV+ DI + + E+ K G + V D
Sbjct: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESK--LQELEKYPGIQTRVLD--- 58
Query: 371 IVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKAV 430
V + +Q+ Q A ++ R+D+L N AG + + E +W+ +N+++ S + + KA
Sbjct: 59 -VTKKKQIDQFA-NEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAF 116
Query: 431 WPIFLKQKSGYIINTTS-TSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVIA 489
P L QKSG IIN +S S + G +C Y+ KAA++G ++++A + ++GI N +
Sbjct: 117 LPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVC 176
Query: 490 P 490
P
Sbjct: 177 P 177
Score = 74.3 bits (181), Expect = 8e-13
Identities = 48/180 (26%), Positives = 87/180 (47%), Gaps = 10/180 (5%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+V+I+T A G+G+ AL +A+ G KV+ D+ +S +QE++K G V +
Sbjct: 7 KVIILTAAAQGIGQAAALAFAREGAKVIATDIN----ESKLQELEKYPGIQTRVLDVTKK 62
Query: 68 SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAW 127
++ + R+D+L N AG + + EK + +++++ + + +A
Sbjct: 63 KQ-----IDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFL 117
Query: 128 PHMRKQKFGRIINTCSPA-GLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
P M QK G IIN S A + G + YS K ++G +S+A + + I N + P
Sbjct: 118 PKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCP 177
>Hs14754051 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 245
Score = 97.4 bits (241), Expect = 8e-20
Identities = 62/181 (34%), Positives = 102/181 (56%), Gaps = 8/181 (4%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
L GKV+I+T + G+G++ A F R GAKV+ DI + + E+ K G + V D
Sbjct: 4 LDGKVIILTAAAQGIGQAAALAFVREGAKVIATDIN--VSKLQELEKYLGIQTRVLD--- 58
Query: 371 IVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKAV 430
V + +Q+ Q A ++ R+D+L N AG + + E +W+ +N+++ ST+ + KA
Sbjct: 59 -VTKKKQIDQFA-NEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSTYLMIKAF 116
Query: 431 WPIFLKQKSGYIINTTS-TSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVIA 489
P L QKSG II S S I G +C Y+ KAA++G ++++A + ++GI N +
Sbjct: 117 LPKMLAQKSGNIITMFSVVSSIKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVC 176
Query: 490 P 490
P
Sbjct: 177 P 177
Score = 67.4 bits (163), Expect = 9e-11
Identities = 45/180 (25%), Positives = 84/180 (46%), Gaps = 10/180 (5%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+V+I+T A G+G+ AL + + G KV+ D+ S +QE++K G V +
Sbjct: 7 KVIILTAAAQGIGQAAALAFVREGAKVIATDINVSK----LQELEKYLGIQTRVLDVTKK 62
Query: 68 SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAW 127
++ + R+D+L N AG + + EK + +++++ + + +A
Sbjct: 63 KQ-----IDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSTYLMIKAFL 117
Query: 128 PHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
P M QK G II S + + G + YS K ++G +S+A + + I N + P
Sbjct: 118 PKMLAQKSGNIITMFSVVSSIKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCP 177
>CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 307
Score = 97.1 bits (240), Expect = 1e-19
Identities = 64/218 (29%), Positives = 106/218 (48%), Gaps = 13/218 (5%)
Query: 303 NGPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSA--VVDEINKKYG 360
NG +P KS+ GK V+ITGSGSG+G+ A FA+ GA+VVI D+ A +++ K G
Sbjct: 29 NGVLPRKSVEGKKVLITGSGSGIGRLMALEFAKLGAEVVIWDVNKDGAEETKNQVVKAGG 88
Query: 361 SGSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHL 420
S K+ +V + + G +DIL+NNAGI+ + ++ + V+
Sbjct: 89 KASTFVVDLSQYKDIHKVAKETKEAVGDIDILINNAGIVTGKKLFDCPDELMEKTMAVNT 148
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE--- 477
+ F +K P L++ +G+++ S +G G G +Y A+K +G ++A+E
Sbjct: 149 NALFYTAKNFLPSMLEKDNGHLVTIASMAGKTGCVGLVDYCASKHGAIGCHDSIAMEILA 208
Query: 478 GTKRGITVNVIAP--------HAETAMTKTIFSSKELN 507
K G+ ++ P H T +F E N
Sbjct: 209 QKKYGVNTTLVCPFFIDTGMFHGVTTKCPALFPILEAN 246
Score = 95.5 bits (236), Expect = 3e-19
Identities = 58/181 (32%), Positives = 93/181 (51%), Gaps = 5/181 (2%)
Query: 10 VIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA-VANYDSVS 68
V+ITG+G G+GR+ ALE+AK G +VV+ D+ + A+ ++ K GG+ V +
Sbjct: 42 VLITGSGSGIGRLMALEFAKLGAEVVIWDVNKDGAEETKNQVVKAGGKASTFVVDLSQYK 101
Query: 69 DNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWP 128
D ET + G +DILINNAGI+ ++ ++ + V+ N F + P
Sbjct: 102 DIHKVAKETKEA-VGDIDILINNAGIVTGKKLFDCPDELMEKTMAVNTNALFYTAKNFLP 160
Query: 129 HMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE---GYKYNINVNSIA 185
M ++ G ++ S AG G G +Y A+K G +G +S+A E KY +N +
Sbjct: 161 SMLEKDNGHLVTIASMAGKTGCVGLVDYCASKHGAIGCHDSIAMEILAQKKYGVNTTLVC 220
Query: 186 P 186
P
Sbjct: 221 P 221
>At1g62610 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 307
Score = 95.5 bits (236), Expect = 3e-19
Identities = 80/254 (31%), Positives = 128/254 (49%), Gaps = 24/254 (9%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVA- 62
E KD+VV++TGA G+GR L+ K G K+V +S+ EI G G A
Sbjct: 43 ELKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAAA 102
Query: 63 ---NYDSVSDNGAAIVETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVHLNG 118
+ S +D V+ A FG +D+LINNAGI + S +S++++ +V +L G
Sbjct: 103 LELDVSSDADTIRKAVKEAWEIFGTIDVLINNAGIRGNVKSSLDLSKEEWDKVFRTNLTG 162
Query: 119 AFKLTRAAWPHMRKQK-FGRIINTCSPAGLYGNF--GQANYSAAKLGLLGFGESLAKEGY 175
++ +++ MR K G +IN S +GL+ G Y+ +K G+ +A E
Sbjct: 163 SWLISKYVCLLMRDAKRGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELA 222
Query: 176 KYNINVNSIAP-LARSAMTENVIPANILKELGPEKIAP-------------LILYLTHEN 221
Y I VNSIAP + RS +T+ + L+++ EKI P L+ YL H++
Sbjct: 223 VYKIRVNSIAPGIFRSEITQGLFQKEWLEKV-TEKIVPLKMQQTVDPGLTSLVRYLIHDS 281
Query: 222 TK-VTNNIFELAAG 234
++ VT N + + +G
Sbjct: 282 SQYVTGNTYIVDSG 295
Score = 79.3 bits (194), Expect = 2e-14
Identities = 60/194 (30%), Positives = 102/194 (51%), Gaps = 10/194 (5%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVV--INDIRDPSAVVDEINKKYGSG-S 363
P L+ KVV++TG+ SG+G+ + G K+V + +++ EIN G
Sbjct: 40 PWCELKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQ 99
Query: 364 AVADTHDIVKEA---QQVVQTAVDKFGRVDILVNNAGILRD-RSFAKMTEDEWNAVINVH 419
A A D+ +A ++ V+ A + FG +D+L+NNAGI + +S ++++EW+ V +
Sbjct: 100 AAALELDVSSDADTIRKAVKEAWEIFGTIDVLINNAGIRGNVKSSLDLSKEEWDKVFRTN 159
Query: 420 LFSTFALSKAVWPIFLKQK-SGYIINTTSTSGIYGNF--GQCNYAAAKAAILGFSRTLAL 476
L ++ +SK V + K G +IN +S SG++ G YA +K + +R +A+
Sbjct: 160 LTGSWLISKYVCLLMRDAKRGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAI 219
Query: 477 EGTKRGITVNVIAP 490
E I VN IAP
Sbjct: 220 ELAVYKIRVNSIAP 233
>At1g52340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 285
Score = 95.1 bits (235), Expect = 4e-19
Identities = 63/200 (31%), Positives = 104/200 (51%), Gaps = 20/200 (10%)
Query: 306 IPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAV 365
+P + L GKV +ITG +G+G+S + F ++GAKV I D++D E+ K G +
Sbjct: 13 LPSQRLLGKVALITGGATGIGESIVRLFHKHGAKVCIVDLQDDLG--GEVCKSLLRGESK 70
Query: 366 ADT---HDIVK---EAQQVVQTAVDKFGRVDILVNNAGI-------LRDRSFAKMTEDEW 412
H V+ + V AV FG +DIL+NNAG+ +R+ S + E+
Sbjct: 71 ETAFFIHGDVRVEDDISNAVDFAVKNFGTLDILINNAGLCGAPCPDIRNYSLS-----EF 125
Query: 413 NAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSR 472
+V++ F K + + +K G I++ S G+ G G +Y +K A+LG +R
Sbjct: 126 EMTFDVNVKGAFLSMKHAARVMIPEKKGSIVSLCSVGGVVGGVGPHSYVGSKHAVLGLTR 185
Query: 473 TLALEGTKRGITVNVIAPHA 492
++A E + GI VN ++P+A
Sbjct: 186 SVAAELGQHGIRVNCVSPYA 205
Score = 89.7 bits (221), Expect = 2e-17
Identities = 61/187 (32%), Positives = 92/187 (48%), Gaps = 8/187 (4%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDS- 66
+V +ITG G+G + K G KV + DL V + + L GE A +
Sbjct: 21 KVALITGGATGIGESIVRLFHKHGAKVCIVDLQDDLGGEVCKSL--LRGESKETAFFIHG 78
Query: 67 ---VSDNGAAIVETAISNFGRVDILINNAGILRDS--SFAKMSEKQFQQVIDVHLNGAFK 121
V D+ + V+ A+ NFG +DILINNAG+ S +F+ DV++ GAF
Sbjct: 79 DVRVEDDISNAVDFAVKNFGTLDILINNAGLCGAPCPDIRNYSLSEFEMTFDVNVKGAFL 138
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINV 181
+ A M +K G I++ CS G+ G G +Y +K +LG S+A E ++ I V
Sbjct: 139 SMKHAARVMIPEKKGSIVSLCSVGGVVGGVGPHSYVGSKHAVLGLTRSVAAELGQHGIRV 198
Query: 182 NSIAPLA 188
N ++P A
Sbjct: 199 NCVSPYA 205
>7290386 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 176
Score = 94.7 bits (234), Expect = 5e-19
Identities = 63/167 (37%), Positives = 84/167 (49%), Gaps = 7/167 (4%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+V ++TGAG G+GR A+ G KV+ D AA VQE LG E A D
Sbjct: 9 KVALVTGAGSGIGRATCRLLARDGAKVIAVDRNLKAAQETVQE---LGSERSAALEVDVS 65
Query: 68 SDNGAAI-VETAISNFGRVD-ILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRA 125
S V A+ F + I++N+AGI RD KM E+ + V V+L G F +T+A
Sbjct: 66 SAQSVQFSVAEALKKFQQAPTIVVNSAGITRDGYLLKMPERDYDDVYGVNLKGTFLVTQA 125
Query: 126 AWPHMRKQKF--GRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESL 170
M +QK G I+N S N GQANY+A K G++ F E L
Sbjct: 126 YAKAMIEQKLENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTERL 172
Score = 92.0 bits (227), Expect = 4e-18
Identities = 63/170 (37%), Positives = 95/170 (55%), Gaps = 9/170 (5%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
L GKV ++TG+GSG+G++ + AR GAKV+ D R+ A + + + SA +
Sbjct: 6 LAGKVALVTGAGSGIGRATCRLLARDGAKVIAVD-RNLKAAQETVQELGSERSAALEVD- 63
Query: 371 IVKEAQQV---VQTAVDKFGRV-DILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFAL 426
V AQ V V A+ KF + I+VN+AGI RD KM E +++ V V+L TF +
Sbjct: 64 -VSSAQSVQFSVAEALKKFQQAPTIVVNSAGITRDGYLLKMPERDYDDVYGVNLKGTFLV 122
Query: 427 SKAVWPIFLKQK--SGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTL 474
++A ++QK +G I+N +S N GQ NYAA KA ++ F+ L
Sbjct: 123 TQAYAKAMIEQKLENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTERL 172
>SPAC922.06 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 94.0 bits (232), Expect = 9e-19
Identities = 65/187 (34%), Positives = 101/187 (53%), Gaps = 19/187 (10%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTH 369
++ G+VV+ITG+ G+GK + F G +V DI DPS V D +A+A
Sbjct: 2 TVEGRVVLITGAAGGIGKVLCKMFTELGDRVAGIDIVDPSKVQD---------AALALQA 52
Query: 370 DIVKEAQQVVQTAVDK----FGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
D+ K Q ++TA++K G +D+L+NNAG+ D F +++ + W+ +++ L +
Sbjct: 53 DVSKADQ--IETAIEKVIQTLGPIDVLINNAGLADDTPFEQLSHESWDHDVSLVLRGNYL 110
Query: 426 LSKAVWPIFLKQ-KSGYIINTTSTSG-IYGNFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
+ V P KQ K G I+N S +G IY G Y+AAKA + ++ LA+ GI
Sbjct: 111 TQRYVIPHMAKQGKGGSIVNIGSVNGHIY--LGSPAYSAAKAGLENLTKALAVRYGPLGI 168
Query: 484 TVNVIAP 490
VNV AP
Sbjct: 169 RVNVCAP 175
Score = 83.2 bits (204), Expect = 2e-15
Identities = 63/180 (35%), Positives = 89/180 (49%), Gaps = 11/180 (6%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
RVV+ITGA GG+G+V + + G +V D+ S VQ+ L + D S
Sbjct: 6 RVVLITGAAGGIGKVLCKMFTELGDRVAGIDI---VDPSKVQDAA-LALQADV-----SK 56
Query: 68 SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAW 127
+D +E I G +D+LINNAG+ D+ F ++S + + + + L G + R
Sbjct: 57 ADQIETAIEKVIQTLGPIDVLINNAGLADDTPFEQLSHESWDHDVSLVLRGNYLTQRYVI 116
Query: 128 PHMRKQ-KFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
PHM KQ K G I+N S G + G YSAAK GL ++LA I VN AP
Sbjct: 117 PHMAKQGKGGSIVNIGSVNG-HIYLGSPAYSAAKAGLENLTKALAVRYGPLGIRVNVCAP 175
>7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 325
Score = 94.0 bits (232), Expect = 9e-19
Identities = 61/220 (27%), Positives = 111/220 (49%), Gaps = 14/220 (6%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLG-----GEG 58
+ +VV+ITG GGG+GR+ AL +A+ ++V+ D+ + A + V + K G G
Sbjct: 53 DISGQVVLITGGGGGVGRLIALNFARLQARIVIWDINQEAIKTTVDLLAKHGYDNCKGYV 112
Query: 59 DAVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNG 118
+++ + + + + E G VDILINNAGI+ F ++ ++ Q ++++
Sbjct: 113 VDISDREQIYQRASQVTEEV----GPVDILINNAGIVCCKPFWELHDRVIQNTYNINIIS 168
Query: 119 AFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE----G 174
+ +A PHM + G I+ S G+ G +G ++Y+A K +GF ESL + G
Sbjct: 169 HYWTVKAFLPHMMRNNRGHIVTVGSVTGMLGTYGCSDYAATKYACIGFHESLLTDLKAHG 228
Query: 175 YKYNINVNSIAPLARSAMTENVIPANILKELGPEKIAPLI 214
Y I ++ I P + + + ++ L P+ +A I
Sbjct: 229 YD-QIQMSLICPYYINTGMFSGVRPRMMPMLEPQYVADRI 267
Score = 92.0 bits (227), Expect = 4e-18
Identities = 60/191 (31%), Positives = 103/191 (53%), Gaps = 8/191 (4%)
Query: 308 IKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVD-EINKKYGSGSAVA 366
+K + G+VV+ITG G G+G+ A FAR A++VI DI + ++ K+G +
Sbjct: 51 LKDISGQVVLITGGGGGVGRLIALNFARLQARIVIWDINQEAIKTTVDLLAKHGYDNCKG 110
Query: 367 DTHDIVKEAQQVVQTA---VDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFST 423
DI + +Q+ Q A ++ G VDIL+NNAGI+ + F ++ + N+++ S
Sbjct: 111 YVVDI-SDREQIYQRASQVTEEVGPVDILINNAGIVCCKPFWELHDRVIQNTYNINIISH 169
Query: 424 FALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG- 482
+ KA P ++ G+I+ S +G+ G +G +YAA K A +GF +L + G
Sbjct: 170 YWTVKAFLPHMMRNNRGHIVTVGSVTGMLGTYGCSDYAATKYACIGFHESLLTDLKAHGY 229
Query: 483 --ITVNVIAPH 491
I +++I P+
Sbjct: 230 DQIQMSLICPY 240
>Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 179
Score = 92.4 bits (228), Expect = 3e-18
Identities = 58/181 (32%), Positives = 93/181 (51%), Gaps = 9/181 (4%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAK--VVINDIRDPSAVVDEINKKYGSGSAVADTHDI 371
KV + G G+G++ AQ AR G + V+ ++ A ++ G +A + D+
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLG-----GDHLAFSCDV 57
Query: 372 VKE--AQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKA 429
KE Q + GRV+ LVN AGI RD + ++ + ++ +L + KA
Sbjct: 58 AKEHDVQNTFEEMEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
Query: 430 VWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVIA 489
++Q+ G I+N S G+ GN GQ Y+A+K ++GFSR LA E ++ I VNV+A
Sbjct: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177
Query: 490 P 490
P
Sbjct: 178 P 178
Score = 86.7 bits (213), Expect = 1e-16
Identities = 59/180 (32%), Positives = 90/180 (49%), Gaps = 3/180 (1%)
Query: 7 DRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDS 66
D+V + G G+GR A A++G ++ V A + + LGG+ A + +
Sbjct: 2 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGD---LGGDHLAFSCDVA 58
Query: 67 VSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAA 126
+ E + GRV+ L+N AGI RD + + + +L G+ +AA
Sbjct: 59 KEHDVQNTFEEMEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAA 118
Query: 127 WPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
M +Q+ G I+N S GL GN GQ+ YSA+K GL+GF +LAKE + I VN +AP
Sbjct: 119 MRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAP 178
>At3g26770 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 92.4 bits (228), Expect = 3e-18
Identities = 58/187 (31%), Positives = 100/187 (53%), Gaps = 8/187 (4%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
K L GKV +ITG SGLGK+ A F R+GA+VVI D+ + + K+ GS +
Sbjct: 13 KKLEGKVALITGGASGLGKATASEFLRHGARVVIADLDAETGT--KTAKELGSEAEFVRC 70
Query: 369 HDIVKEAQ--QVVQTAVDKFGRVDILVNNAGI---LRDRSFAKMTEDEWNAVINVHLFST 423
D+ EA V+ V+++G++D++ NNAGI + S +++ E+ V+ +++F
Sbjct: 71 -DVTVEADIAGAVEMTVERYGKLDVMYNNAGIVGPMTPASISQLDMTEFERVMRINVFGV 129
Query: 424 FALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
+ K + +SG I+ T+S +G+ G +Y +K G ++ A E + G+
Sbjct: 130 VSGIKHAAKFMIPARSGCILCTSSVAGVTGGLAPHSYTISKFTTPGIVKSAASELCEHGV 189
Query: 484 TVNVIAP 490
+N I+P
Sbjct: 190 RINCISP 196
Score = 89.4 bits (220), Expect = 2e-17
Identities = 54/188 (28%), Positives = 101/188 (53%), Gaps = 6/188 (3%)
Query: 2 SLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAV 61
S + + +V +ITG GLG+ A E+ + G +VV+ DL A++ + K+LG E + V
Sbjct: 12 SKKLEGKVALITGGASGLGKATASEFLRHGARVVIADLD---AETGTKTAKELGSEAEFV 68
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGI---LRDSSFAKMSEKQFQQVIDVHLNG 118
+V + A VE + +G++D++ NNAGI + +S +++ +F++V+ +++ G
Sbjct: 69 RCDVTVEADIAGAVEMTVERYGKLDVMYNNAGIVGPMTPASISQLDMTEFERVMRINVFG 128
Query: 119 AFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYN 178
+ A M + G I+ T S AG+ G +Y+ +K G +S A E ++
Sbjct: 129 VVSGIKHAAKFMIPARSGCILCTSSVAGVTGGLAPHSYTISKFTTPGIVKSAASELCEHG 188
Query: 179 INVNSIAP 186
+ +N I+P
Sbjct: 189 VRINCISP 196
>At3g46170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 288
Score = 92.0 bits (227), Expect = 4e-18
Identities = 75/253 (29%), Positives = 124/253 (48%), Gaps = 23/253 (9%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEG--DAV 61
E KD+VV++TGA G+GR L+ K G K++ +S+ EI G A
Sbjct: 25 ELKDKVVLVTGASSGIGREICLDLGKAGCKIIAVARRVDRLNSLCSEINSSSSTGIQAAA 84
Query: 62 ANYDSVSDNGA--AIVETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVHLNG 118
D SD +V+ A FG++D LINNAGI + S +S++++ V +L G
Sbjct: 85 LKLDVTSDAATIQKVVQGAWGIFGKIDALINNAGIRGNVKSSLDLSKEEWDNVFKTNLTG 144
Query: 119 AFKLTRAAWPHMRKQKF-GRIINTCSPAGLYGNF-GQANYSAAKLGLLGFGESLAKEGYK 176
+ +++ MR K G +IN S AG+ G G Y+ +K+G+ + +A E
Sbjct: 145 PWLVSKYVCVLMRDAKLGGSVINISSIAGIRGILPGALAYACSKIGVDTMSKMMAVELGV 204
Query: 177 YNINVNSIAP------LARSAM--------TENVIPANILKELGPEKIAPLILYLTHENT 222
+ I VNSIAP + + M TE +P + + + P I L+ YL H+++
Sbjct: 205 HKIRVNSIAPGIFKSEITQGLMQKEWFKNVTERTVPLKLQQTVDP-GITSLVRYLIHDSS 263
Query: 223 K-VTNNIFELAAG 234
+ ++ N + + +G
Sbjct: 264 QYISGNTYIVDSG 276
Score = 84.0 bits (206), Expect = 1e-15
Identities = 64/193 (33%), Positives = 102/193 (52%), Gaps = 9/193 (4%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKV--VINDIRDPSAVVDEINKKYGSG-S 363
P L+ KVV++TG+ SG+G+ + G K+ V + +++ EIN +G
Sbjct: 22 PWCELKDKVVLVTGASSGIGREICLDLGKAGCKIIAVARRVDRLNSLCSEINSSSSTGIQ 81
Query: 364 AVADTHDIVKEA---QQVVQTAVDKFGRVDILVNNAGILRD-RSFAKMTEDEWNAVINVH 419
A A D+ +A Q+VVQ A FG++D L+NNAGI + +S ++++EW+ V +
Sbjct: 82 AAALKLDVTSDAATIQKVVQGAWGIFGKIDALINNAGIRGNVKSSLDLSKEEWDNVFKTN 141
Query: 420 LFSTFALSKAVWPIFLKQK-SGYIINTTSTSGIYGNF-GQCNYAAAKAAILGFSRTLALE 477
L + +SK V + K G +IN +S +GI G G YA +K + S+ +A+E
Sbjct: 142 LTGPWLVSKYVCVLMRDAKLGGSVINISSIAGIRGILPGALAYACSKIGVDTMSKMMAVE 201
Query: 478 GTKRGITVNVIAP 490
I VN IAP
Sbjct: 202 LGVHKIRVNSIAP 214
>At3g26760 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 91.3 bits (225), Expect = 6e-18
Identities = 63/190 (33%), Positives = 102/190 (53%), Gaps = 14/190 (7%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSA--VVDEINKKYGSGSAVA 366
+ L GKV +ITG SG+GK+ A+ F GA+V+I DI + + V E+ GSA
Sbjct: 3 RKLEGKVAVITGGASGIGKATAEEFVSQGAQVIIVDIDEEAGHMVATEL------GSAAH 56
Query: 367 DTHDIVKEAQQV---VQTAVDKFGRVDILVNNAGI---LRDRSFAKMTEDEWNAVINVHL 420
V E +Q+ V+TAV + G++D+++N+AGI + S A + D ++ V+ +++
Sbjct: 57 FLRCDVTEEEQIAKAVETAVTRHGKLDVMLNSAGISCSISPPSIADLDMDTYDKVMRLNV 116
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTK 480
T K + SG I+ +S SG+ G G Y+ +K I G +T+A E K
Sbjct: 117 RGTVLGIKHAARAMIPAGSGSILCLSSISGLMGGLGPHAYSISKFTIPGVVKTVASELCK 176
Query: 481 RGITVNVIAP 490
G+ +N I+P
Sbjct: 177 HGLRINCISP 186
Score = 78.6 bits (192), Expect = 4e-14
Identities = 51/189 (26%), Positives = 94/189 (48%), Gaps = 6/189 (3%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA 60
M + + +V +ITG G+G+ A E+ +G +V++ D+ A V E LG
Sbjct: 1 MYRKLEGKVAVITGGASGIGKATAEEFVSQGAQVIIVDIDEEAGHMVATE---LGSAAHF 57
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGI---LRDSSFAKMSEKQFQQVIDVHLN 117
+ + + A VETA++ G++D+++N+AGI + S A + + +V+ +++
Sbjct: 58 LRCDVTEEEQIAKAVETAVTRHGKLDVMLNSAGISCSISPPSIADLDMDTYDKVMRLNVR 117
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
G + A M G I+ S +GL G G YS +K + G +++A E K+
Sbjct: 118 GTVLGIKHAARAMIPAGSGSILCLSSISGLMGGLGPHAYSISKFTIPGVVKTVASELCKH 177
Query: 178 NINVNSIAP 186
+ +N I+P
Sbjct: 178 GLRINCISP 186
>At4g03140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 283
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/190 (34%), Positives = 98/190 (51%), Gaps = 7/190 (3%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
+ L GKV +ITG SG+GK+ A F +GAKV+I DI+ + E ++ G A
Sbjct: 16 RKLEGKVALITGGASGIGKATAGKFISHGAKVIIADIQPQ--IGRETEQELGPSCAYFPC 73
Query: 369 HDIVKEAQ--QVVQTAVDKFGRVDILVNNAGI--LRDRSFAKMTEDEWNAVINVHLFSTF 424
D+ KE+ V AV ++DI+ NNAGI S + + ++ VIN ++
Sbjct: 74 -DVTKESDIANAVDFAVSLHTKLDIMYNNAGIPCKTPPSIVDLDLNVFDKVINTNVRGVM 132
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
A K + + + SG II S +G+ G Q Y+ +K+A++G R+ A E K I
Sbjct: 133 AGIKHAARVMIPRNSGSIICAGSVTGMMGGLAQHTYSVSKSAVIGIVRSTASELCKHRIR 192
Query: 485 VNVIAPHAET 494
VN I+P A T
Sbjct: 193 VNCISPFAIT 202
Score = 75.5 bits (184), Expect = 3e-13
Identities = 55/188 (29%), Positives = 87/188 (46%), Gaps = 7/188 (3%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVAN 63
+ + +V +ITG G+G+ A ++ G KV++ D+ QE+ G A
Sbjct: 17 KLEGKVALITGGASGIGKATAGKFISHGAKVIIADIQPQIGRETEQEL----GPSCAYFP 72
Query: 64 YDSVSDNGAA-IVETAISNFGRVDILINNAGI--LRDSSFAKMSEKQFQQVIDVHLNGAF 120
D ++ A V+ A+S ++DI+ NNAGI S + F +VI+ ++ G
Sbjct: 73 CDVTKESDIANAVDFAVSLHTKLDIMYNNAGIPCKTPPSIVDLDLNVFDKVINTNVRGVM 132
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
+ A M + G II S G+ G Q YS +K ++G S A E K+ I
Sbjct: 133 AGIKHAARVMIPRNSGSIICAGSVTGMMGGLAQHTYSVSKSAVIGIVRSTASELCKHRIR 192
Query: 181 VNSIAPLA 188
VN I+P A
Sbjct: 193 VNCISPFA 200
>7296705 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 90.9 bits (224), Expect = 8e-18
Identities = 62/189 (32%), Positives = 101/189 (52%), Gaps = 14/189 (7%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKY------GSGS 363
S + KV+I+TG+ SG+G + A+ G + I +D++N+ G
Sbjct: 3 SFKDKVIIVTGASSGIGAGTSVLLAKLGGLLTI-----VGRNLDKLNETAEQIVAAGGAP 57
Query: 364 AVADTHDIVKEA--QQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
A+ DI E+ Q +V + K GR+D+LVNNAGIL S + ++++ V+N ++
Sbjct: 58 ALQVAADINSESDVQGIVSATLAKHGRIDVLVNNAGILELGSIENTSLEQFDRVMNTNVR 117
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
S + L+ V P +K K G I+N +S +GI G Y +KAA+ F+R +ALE +
Sbjct: 118 SLYQLTHLVTPELIKTK-GNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPK 176
Query: 482 GITVNVIAP 490
G+ VN + P
Sbjct: 177 GVRVNSVNP 185
Score = 90.1 bits (222), Expect = 1e-17
Identities = 58/184 (31%), Positives = 93/184 (50%), Gaps = 4/184 (2%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEG--DAVA 62
FKD+V+I+TGA G+G ++ AK GG + + + ++I GG A
Sbjct: 4 FKDKVIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVAA 63
Query: 63 NYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKL 122
+ +S SD IV ++ GR+D+L+NNAGIL S S +QF +V++ ++ ++L
Sbjct: 64 DINSESDV-QGIVSATLAKHGRIDVLVNNAGILELGSIENTSLEQFDRVMNTNVRSLYQL 122
Query: 123 TRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVN 182
T P + K K G I+N S G+ G Y+ +K + F +A E + VN
Sbjct: 123 THLVTPELIKTK-GNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVN 181
Query: 183 SIAP 186
S+ P
Sbjct: 182 SVNP 185
>At3g05260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 289
Score = 90.5 bits (223), Expect = 1e-17
Identities = 61/193 (31%), Positives = 92/193 (47%), Gaps = 11/193 (5%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVIN--------DIRDPSAVVDEINKK 358
P L GKV ++TG SG+GK+ +A GA V D + ++ E+ +
Sbjct: 33 PSNKLHGKVALVTGGDSGIGKAVCHCYALEGASVAFTYVKGREDKDAEETLRLLHEVKTR 92
Query: 359 YGSGSAVADTH-DIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVIN 417
+ T + ++VV+ V+ FGR+D+LVN A + S + E V
Sbjct: 93 EAKEPIMIATDLGFEENCKRVVEEVVNSFGRIDVLVNCAAEQHEVSIEDIDEARLERVFR 152
Query: 418 VHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
++FS F L K + + ++ IINTTS GN Y A K AI+ F+R LAL+
Sbjct: 153 TNIFSQFFLVK--YALKHMKEGSSIINTTSVVAYAGNSSLLEYTATKGAIVSFTRGLALQ 210
Query: 478 GTKRGITVNVIAP 490
+GI VN +AP
Sbjct: 211 LAPKGIRVNGVAP 223
Score = 75.1 bits (183), Expect = 4e-13
Identities = 64/252 (25%), Positives = 112/252 (44%), Gaps = 16/252 (6%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDL-GRSAADS-----VVQEIK-KLGGEGDA 60
+V ++TG G+G+ YA G V + GR D+ ++ E+K + E
Sbjct: 40 KVALVTGGDSGIGKAVCHCYALEGASVAFTYVKGREDKDAEETLRLLHEVKTREAKEPIM 99
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
+A +N +VE +++FGR+D+L+N A + S + E + ++V ++ F
Sbjct: 100 IATDLGFEENCKRVVEEVVNSFGRIDVLVNCAAEQHEVSIEDIDEARLERVFRTNIFSQF 159
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
L + A HM++ IINT S GN Y+A K ++ F LA + I
Sbjct: 160 FLVKYALKHMKEG--SSIINTTSVVAYAGNSSLLEYTATKGAIVSFTRGLALQLAPKGIR 217
Query: 181 VNSIAPLARSAMTENVIPANILKELGPEKIAPLILYLTHENTKVTNNIFELAAGFYSQIR 240
VN +AP + +IPA+ +E + + + + +V + LA S
Sbjct: 218 VNGVAP---GPVWTPLIPASFSEEAIKQFGSETPMKRAAQPVEVAPSYVFLACNHCSSY- 273
Query: 241 WERSSGELFHPN 252
+G++ HPN
Sbjct: 274 ---YTGQILHPN 282
>CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 427
Score = 89.7 bits (221), Expect = 2e-17
Identities = 57/173 (32%), Positives = 91/173 (51%), Gaps = 14/173 (8%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA------- 60
+ VIITG G GLGR AL++AKR KV + D+ + ++ +K + EG+
Sbjct: 42 QTVIITGGGSGLGRAMALDFAKRKAKVAIIDVNKEGG---LETVKTIAAEGNMAKFWYCD 98
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
+++ D++ I +T FG V+I+I NA IL +SF ++S++ ++ +DV++ G
Sbjct: 99 ISDVDNMKKTAKEIEDT----FGDVNIVICNAAILSFTSFMEISDELLRKCLDVNIFGTI 154
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
RA P M + G I+ CS AG G +Y +K + G ESL E
Sbjct: 155 NTIRAFLPKMETKNDGHIVCVCSIAGWSGETMGLSYCTSKFAVRGAMESLQME 207
Score = 79.7 bits (195), Expect = 2e-14
Identities = 53/178 (29%), Positives = 92/178 (50%), Gaps = 4/178 (2%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
KS++G+ VIITG GSGLG++ A FA+ AKV I D+ + + + G+
Sbjct: 37 KSVQGQTVIITGGGSGLGRAMALDFAKRKAKVAIIDVNKEGGL-ETVKTIAAEGNMAKFW 95
Query: 369 HDIVKEAQQVVQTAV---DKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
+ + + + +TA D FG V+I++ NA IL SF +++++ ++V++F T
Sbjct: 96 YCDISDVDNMKKTAKEIEDTFGDVNIVICNAAILSFTSFMEISDELLRKCLDVNIFGTIN 155
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
+A P + G+I+ S +G G +Y +K A+ G +L +E RG+
Sbjct: 156 TIRAFLPKMETKNDGHIVCVCSIAGWSGETMGLSYCTSKFAVRGAMESLQMELRDRGL 213
>At3g55310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 298
Score = 89.7 bits (221), Expect = 2e-17
Identities = 74/253 (29%), Positives = 123/253 (48%), Gaps = 23/253 (9%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVAN 63
E KD+VV++TGA G+GR L+ AK G +V+ +S+ EI G A
Sbjct: 35 ELKDKVVLVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQAAA 94
Query: 64 YDSVSDNGAAIVETAISN----FGRVDILINNAGILRDSSFA-KMSEKQFQQVIDVHLNG 118
+ + AA ++ A+ FG++D LINNAGI + + +SE ++ V + +L G
Sbjct: 95 LELDVSSDAATIQKAVREAWDIFGKIDALINNAGIRGNVKLSLDLSEDEWDNVFNTNLKG 154
Query: 119 AFKLTRAAWPHMRKQK-FGRIINTCSPAGLYGNF-GQANYSAAKLGLLGFGESLAKEGYK 176
+ + + MR K G +IN S AG+ G YS +K G+ +A E
Sbjct: 155 PWLVAKYVCVLMRDAKRGGSVINISSVAGVRSIVPGGLAYSCSKGGVDTMSRMMAIELGV 214
Query: 177 YNINVNSIAP-LARSA-------------MTENVIPANILKELGPEKIAPLILYLTHENT 222
+ I VNSIAP L +S +TE +P + + + P + L+ YL H+++
Sbjct: 215 HKIRVNSIAPGLFKSEITQALMQKEWLKNVTERTVPLKVQQTIDP-GLTSLVRYLIHDSS 273
Query: 223 K-VTNNIFELAAG 234
+ ++ N + + +G
Sbjct: 274 QYISGNTYIVDSG 286
Score = 83.2 bits (204), Expect = 2e-15
Identities = 75/249 (30%), Positives = 121/249 (48%), Gaps = 23/249 (9%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP--SAVVDEINKKYGSG-S 363
P L+ KVV++TG+ SG+G+ A+ G +V+ R +++ EIN +G
Sbjct: 32 PWCELKDKVVLVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQ 91
Query: 364 AVADTHDIVKEA---QQVVQTAVDKFGRVDILVNNAGILRDRSFA-KMTEDEWNAVINVH 419
A A D+ +A Q+ V+ A D FG++D L+NNAGI + + ++EDEW+ V N +
Sbjct: 92 AAALELDVSSDAATIQKAVREAWDIFGKIDALINNAGIRGNVKLSLDLSEDEWDNVFNTN 151
Query: 420 LFSTFALSKAVWPIFLKQK-SGYIINTTSTSGIYGNF-GQCNYAAAKAAILGFSRTLALE 477
L + ++K V + K G +IN +S +G+ G Y+ +K + SR +A+E
Sbjct: 152 LKGPWLVAKYVCVLMRDAKRGGSVINISSVAGVRSIVPGGLAYSCSKGGVDTMSRMMAIE 211
Query: 478 GTKRGITVNVIAPHA-ETAMTKTIFSSKELNN------------HFDPGFVSPFVVLLCS 524
I VN IAP ++ +T+ + + L N DPG S V L
Sbjct: 212 LGVHKIRVNSIAPGLFKSEITQALMQKEWLKNVTERTVPLKVQQTIDPGLTS-LVRYLIH 270
Query: 525 DELQELGKN 533
D Q + N
Sbjct: 271 DSSQYISGN 279
>At2g47120 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 89.7 bits (221), Expect = 2e-17
Identities = 75/224 (33%), Positives = 114/224 (50%), Gaps = 9/224 (4%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP--SAVVDEINKKYGSGSAVADT 368
L GK+VIITG SG+G A+ F +GAKVVI D+++ V I K S T
Sbjct: 6 LEGKIVIITGGASGIGADAARLFTDHGAKVVIVDVQEELGQNVAVLIGKDKASFYRCDVT 65
Query: 369 HDIVKEAQQVVQTAVDKFGRVDILVNNAGILRD-RSFAKMTEDEWNAVINVHLFSTFALS 427
++ E + V+ V+K G++D+L +NAG+L SF + ++ ++ V++ A
Sbjct: 66 NE--TEVEDAVKFTVEKHGKLDVLFSNAGVLEPLESFLDFDLERFDRIMAVNVRGAAAFI 123
Query: 428 K-AVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
K A + K G I+ TTS S G G Y A+K ++G R+ + K GI VN
Sbjct: 124 KHAARAMVEKGTRGSIVCTTSVSAEIGG-GHHGYTASKHGLVGLIRSACGDLGKYGIRVN 182
Query: 487 VIAPHA-ETAMTK-TIFSSKELNNHFDPGFVSPFVVLLCSDELQ 528
+AP+A T MT + K+L ++FD + +VL S Q
Sbjct: 183 GVAPYAVATPMTSHDEVTGKQLEDYFDAKGILKGMVLKASHVAQ 226
Score = 75.5 bits (184), Expect = 3e-13
Identities = 60/194 (30%), Positives = 94/194 (47%), Gaps = 17/194 (8%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA-- 60
L + ++VIITG G+G A + G KVV+ D+ + + Q + L G+ A
Sbjct: 4 LRLEGKIVIITGGASGIGADAARLFTDHGAKVVIVDV----QEELGQNVAVLIGKDKASF 59
Query: 61 ----VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVH 115
V N V D V+ + G++D+L +NAG+L SF ++F +++ V+
Sbjct: 60 YRCDVTNETEVED----AVKFTVEKHGKLDVLFSNAGVLEPLESFLDFDLERFDRIMAVN 115
Query: 116 LNGAFK-LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEG 174
+ GA + AA + K G I+ T S + G G Y+A+K GL+G S +
Sbjct: 116 VRGAAAFIKHAARAMVEKGTRGSIVCTTSVSAEIGG-GHHGYTASKHGLVGLIRSACGDL 174
Query: 175 YKYNINVNSIAPLA 188
KY I VN +AP A
Sbjct: 175 GKYGIRVNGVAPYA 188
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 89.4 bits (220), Expect = 2e-17
Identities = 64/188 (34%), Positives = 103/188 (54%), Gaps = 13/188 (6%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIVK 373
KV IITGS +G+G++ A FAR GAKV I R + + + +G + + + +V
Sbjct: 7 KVAIITGSSNGIGRATAVLFAREGAKVTITG-RHAERLEETRQQILAAGVSEQNVNSVVA 65
Query: 374 EA------QQVVQTAVDKFGRVDILVNNAGILRDRSFAK----MTEDEWNAVINVHLFST 423
+ +++ T + KFG++DILVNNAG S +K + + ++A +N++L S
Sbjct: 66 DVTTDAGQDEILSTTLGKFGKLDILVNNAGAAIPDSQSKTGTAQSIESYDATLNLNLRSV 125
Query: 424 FALSKAVWPIFLKQKSGYIINTTS-TSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
AL+K P L G I+N +S SG++ Y+ AKAAI ++R A++ + G
Sbjct: 126 IALTKKAVP-HLSSTKGEIVNISSIASGLHATPDFPYYSIAKAAIDQYTRNTAIDLIQHG 184
Query: 483 ITVNVIAP 490
I VN I+P
Sbjct: 185 IRVNSISP 192
Score = 85.5 bits (210), Expect = 3e-16
Identities = 69/247 (27%), Positives = 113/247 (44%), Gaps = 32/247 (12%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANY 64
F ++V IITG+ G+GR A+ +A+ G KV + + Q+I G V +
Sbjct: 4 FAEKVAIITGSSNGIGRATAVLFAREGAKVTITGRHAERLEETRQQILAAGVSEQNVNSV 63
Query: 65 --DSVSDNGA-AIVETAISNFGRVDILINNAGILRDSSFAK----MSEKQFQQVIDVHLN 117
D +D G I+ T + FG++DIL+NNAG S +K S + + ++++L
Sbjct: 64 VADVTTDAGQDEILSTTLGKFGKLDILVNNAGAAIPDSQSKTGTAQSIESYDATLNLNLR 123
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCSPA-GLYGNFGQANYSAAKLGLLGFGESLAKEGYK 176
LT+ A PH+ K G I+N S A GL+ YS AK + + + A + +
Sbjct: 124 SVIALTKKAVPHLSSTK-GEIVNISSIASGLHATPDFPYYSIAKAAIDQYTRNTAIDLIQ 182
Query: 177 YNINVNSIAP---------------------LARSAMTENVIPANILKELGPEKIAPLIL 215
+ I VNSI+P + A + +PA ++ + P+ IA +I
Sbjct: 183 HGIRVNSISPGLVATGFGSAMGMPEETSKKFYSTMATMKECVPAGVMGQ--PQDIAEVIA 240
Query: 216 YLTHENT 222
+L T
Sbjct: 241 FLADRKT 247
>7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 255
Score = 89.0 bits (219), Expect = 3e-17
Identities = 62/195 (31%), Positives = 104/195 (52%), Gaps = 19/195 (9%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
++ V ++TG SGLG++ A+ A+ GA V++ D+ PS+ +E+ K+ G V D
Sbjct: 2 IKNAVSLVTGGASGLGRATAERLAKQGASVILADL--PSSKGNEVAKELGD-KVVFVPVD 58
Query: 371 IV--KEAQQVVQTAVDKFGRVDILVNNAGILR-------DRSFAKMTEDEWNAVINVHLF 421
+ K+ +QTA DKFGR+D+ VN AG +++ A ED + VIN++
Sbjct: 59 VTSEKDVSAALQTAKDKFGRLDLTVNCAGTATAVKTFNFNKNVAHRLED-FQRVININTV 117
Query: 422 STFALSKAVWPIFLKQKS------GYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLA 475
TF + + + + G I+NT S + G GQ Y+A+KAA++G + +A
Sbjct: 118 GTFNVIRLSAGLMGANEPNQDGQRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIA 177
Query: 476 LEGTKRGITVNVIAP 490
+ + +GI + IAP
Sbjct: 178 RDLSTQGIRICTIAP 192
Score = 83.2 bits (204), Expect = 2e-15
Identities = 63/195 (32%), Positives = 100/195 (50%), Gaps = 19/195 (9%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
K+ V ++TG GLGR A AK+G V++ DL S + V +E+ G+ D
Sbjct: 3 KNAVSLVTGGASGLGRATAERLAKQGASVILADLPSSKGNEVAKEL----GDKVVFVPVD 58
Query: 66 SVSDNG-AAIVETAISNFGRVDILINNAG---ILRDSSFAKMSE---KQFQQVIDVHLNG 118
S+ +A ++TA FGR+D+ +N AG ++ +F K + FQ+VI+++ G
Sbjct: 59 VTSEKDVSAALQTAKDKFGRLDLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVG 118
Query: 119 AFKLTR-------AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLA 171
F + R A P+ Q+ G I+NT S A G GQA YSA+K ++G +A
Sbjct: 119 TFNVIRLSAGLMGANEPNQDGQR-GVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIA 177
Query: 172 KEGYKYNINVNSIAP 186
++ I + +IAP
Sbjct: 178 RDLSTQGIRICTIAP 192
>At5g50690 [Q] KOG1205 Predicted dehydrogenase
Length = 303
Score = 88.6 bits (218), Expect = 4e-17
Identities = 61/168 (36%), Positives = 85/168 (50%), Gaps = 3/168 (1%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD-S 66
+VVIITG+ G+G A EYA+RG + + V +KLG AV D S
Sbjct: 48 KVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGDVS 107
Query: 67 VSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSE-KQFQQVIDVHLNGAFKLTRA 125
V + V+ IS FGR+D L+NNAGI F SE +++ + G T
Sbjct: 108 VIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGPVYATHF 167
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
A PH++K K G+II SPAG G + Y+A+K ++ F E+L E
Sbjct: 168 AIPHLKKTK-GKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIE 214
Score = 84.0 bits (206), Expect = 1e-15
Identities = 61/173 (35%), Positives = 92/173 (52%), Gaps = 5/173 (2%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIR-DPSAVVDEINKKYGSGSAVAD 367
+ + GKVVIITGS SG+G+ A +AR GA + + R D VV + +K GS
Sbjct: 43 EKVNGKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVV 102
Query: 368 THDI--VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTE-DEWNAVINVHLFSTF 424
D+ +K+ ++ VQ + +FGR+D LVNNAGI + F +E + ++N + +
Sbjct: 103 RGDVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGPV 162
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
+ P LK+ G II S +G G YAA+KAA++ F TL +E
Sbjct: 163 YATHFAIP-HLKKTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIE 214
>At5g50590 [Q] KOG1205 Predicted dehydrogenase
Length = 299
Score = 88.6 bits (218), Expect = 4e-17
Identities = 61/168 (36%), Positives = 85/168 (50%), Gaps = 3/168 (1%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD-S 66
+VVIITG+ G+G A EYA+RG + + V +KLG AV D S
Sbjct: 48 KVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGDVS 107
Query: 67 VSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSE-KQFQQVIDVHLNGAFKLTRA 125
V + V+ IS FGR+D L+NNAGI F SE +++ + G T
Sbjct: 108 VIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGPVYATHF 167
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
A PH++K K G+II SPAG G + Y+A+K ++ F E+L E
Sbjct: 168 AIPHLKKTK-GKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIE 214
Score = 84.0 bits (206), Expect = 1e-15
Identities = 61/173 (35%), Positives = 92/173 (52%), Gaps = 5/173 (2%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIR-DPSAVVDEINKKYGSGSAVAD 367
+ + GKVVIITGS SG+G+ A +AR GA + + R D VV + +K GS
Sbjct: 43 EKVNGKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVV 102
Query: 368 THDI--VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTE-DEWNAVINVHLFSTF 424
D+ +K+ ++ VQ + +FGR+D LVNNAGI + F +E + ++N + +
Sbjct: 103 RGDVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGPV 162
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
+ P LK+ G II S +G G YAA+KAA++ F TL +E
Sbjct: 163 YATHFAIP-HLKKTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIE 214
>CE21092 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 86.3 bits (212), Expect = 2e-16
Identities = 61/190 (32%), Positives = 90/190 (47%), Gaps = 9/190 (4%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGD---AV 61
F D+V IITG+ G+GR A+ A+ G KV V V EI K GG D V
Sbjct: 4 FSDKVAIITGSSSGIGRSTAVLLAQEGAKVTVTGRSSEKIQETVNEIHKNGGSSDNINIV 63
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ----FQQVIDVHLN 117
+ S+ ++++ +S FG++DILINNAG K+ + F ++ ++L
Sbjct: 64 LGDLNESECQDELIKSTLSRFGKIDILINNAGAAFADPSGKIGSEAAIGIFDDMMKLNLR 123
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLAKEGYK 176
+L + PH+ K G I+N S AG Y K GL SLA E
Sbjct: 124 SVVELVKKCRPHLIASK-GEIVNVSSIAAGPQPYIYYTYYGICKAGLDQLTRSLALELIP 182
Query: 177 YNINVNSIAP 186
+++ VNS++P
Sbjct: 183 FDVRVNSVSP 192
Score = 70.1 bits (170), Expect = 1e-11
Identities = 56/187 (29%), Positives = 94/187 (49%), Gaps = 11/187 (5%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVI--NDIRDPSAVVDEINKKYGSGSAVADTHDI 371
KV IITGS SG+G+S A A+ GAKV + V+EI+K GS +
Sbjct: 7 KVAIITGSSSGIGRSTAVLLAQEGAKVTVTGRSSEKIQETVNEIHKNGGSSDNINIVLGD 66
Query: 372 VKEAQ---QVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDE----WNAVINVHLFSTF 424
+ E++ +++++ + +FG++DIL+NNAG K+ + ++ ++ ++L S
Sbjct: 67 LNESECQDELIKSTLSRFGKIDILINNAGAAFADPSGKIGSEAAIGIFDDMMKLNLRSVV 126
Query: 425 ALSKAVWPIFLKQKSGYIINTTS-TSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
L K P + K G I+N +S +G Y KA + +R+LALE +
Sbjct: 127 ELVKKCRPHLIASK-GEIVNVSSIAAGPQPYIYYTYYGICKAGLDQLTRSLALELIPFDV 185
Query: 484 TVNVIAP 490
VN ++P
Sbjct: 186 RVNSVSP 192
>Hs10337605 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 85.5 bits (210), Expect = 3e-16
Identities = 71/250 (28%), Positives = 123/250 (48%), Gaps = 21/250 (8%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
L KV ++T S G+G + A+ A+ GA VV++ R V + G G +V T
Sbjct: 12 LANKVALVTASTDGIGFAIARRLAQDGAHVVVSS-RKQQNVDQAVATLQGEGLSVTGTVC 70
Query: 371 IVKEAQ---QVVQTAVDKFGRVDILVNNAGILRD-RSFAKMTEDEWNAVINVHLFSTFAL 426
V +A+ ++V AV G +DILV+NA + S +TE+ W+ +++++ + +
Sbjct: 71 HVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALM 130
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
+KAV P K+ G ++ +S + + G Y +K A+LG ++TLA+E R I VN
Sbjct: 131 TKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVN 190
Query: 487 VIAPH-AETAMTKTIFSSKELNNHF----------DPGFVSPFVVLLCSDELQELGKNRV 535
+AP +T+ ++ ++ KE +P + V LCS++ + +
Sbjct: 191 CLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSED-----ASYI 245
Query: 536 KGLLFEVGGG 545
G VGGG
Sbjct: 246 TGETVVVGGG 255
Score = 72.4 bits (176), Expect = 3e-12
Identities = 63/250 (25%), Positives = 121/250 (48%), Gaps = 20/250 (8%)
Query: 7 DRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVAN--- 63
++V ++T + G+G A A+ G VVV+ + D Q + L GEG +V
Sbjct: 14 NKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVD---QAVATLQGEGLSVTGTVC 70
Query: 64 YDSVSDNGAAIVETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVHLNGAFKL 122
+ +++ +V A+ G +DIL++NA + S ++E+ + + +D+++ +
Sbjct: 71 HVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALM 130
Query: 123 TRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVN 182
T+A P M K+ G ++ S A + G + Y+ +K LLG ++LA E NI VN
Sbjct: 131 TKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVN 190
Query: 183 SIAP-LARSAMT----------ENVIPANILKELG-PEKIAPLILYLTHENTK-VTNNIF 229
+AP L +++ + E++ ++ LG PE A ++ +L E+ +T
Sbjct: 191 CLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETV 250
Query: 230 ELAAGFYSQI 239
+ G S++
Sbjct: 251 VVGGGTPSRL 260
>At3g03330 [Q] KOG1205 Predicted dehydrogenase
Length = 345
Score = 85.5 bits (210), Expect = 3e-16
Identities = 64/185 (34%), Positives = 92/185 (49%), Gaps = 6/185 (3%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIK-KLGGEGDAVANYDS 66
+VV ITGA G+G + A ++A K++++ ++ D V E+K K E V D
Sbjct: 44 KVVWITGASRGIGEILAKQFASLDAKLILSARNKAELDRVKSELKGKFAPEDVKVLPLDL 103
Query: 67 VSDNGAA--IVETAISNF--GRVDILINNAGILRDSSFAK-MSEKQFQQVIDVHLNGAFK 121
S + +VE A+S F VD L++NA R S A SE+ + DV++ G
Sbjct: 104 ASGEESLKHVVEQAVSLFPGAGVDYLVHNAAFERPKSKASDASEETLKTTFDVNVFGTIS 163
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINV 181
LT+ PHM KQ G + S AG + GQA YSA+K L G+ SL E + I V
Sbjct: 164 LTKLVAPHMLKQGGGHFVVISSAAGKVPSPGQAIYSASKHALHGYFHSLRSEFCQKGIKV 223
Query: 182 NSIAP 186
+ P
Sbjct: 224 TVVCP 228
Score = 84.3 bits (207), Expect = 7e-16
Identities = 60/190 (31%), Positives = 102/190 (53%), Gaps = 8/190 (4%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVIN--DIRDPSAVVDEINKKYGSGSAVA 366
++++GKVV ITG+ G+G+ A+ FA AK++++ + + V E+ K+
Sbjct: 39 EAIQGKVVWITGASRGIGEILAKQFASLDAKLILSARNKAELDRVKSELKGKFAPEDVKV 98
Query: 367 DTHDIV---KEAQQVVQTAVDKF--GRVDILVNNAGILRDRSFAK-MTEDEWNAVINVHL 420
D+ + + VV+ AV F VD LV+NA R +S A +E+ +V++
Sbjct: 99 LPLDLASGEESLKHVVEQAVSLFPGAGVDYLVHNAAFERPKSKASDASEETLKTTFDVNV 158
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTK 480
F T +L+K V P LKQ G+ + +S +G + GQ Y+A+K A+ G+ +L E +
Sbjct: 159 FGTISLTKLVAPHMLKQGGGHFVVISSAAGKVPSPGQAIYSASKHALHGYFHSLRSEFCQ 218
Query: 481 RGITVNVIAP 490
+GI V V+ P
Sbjct: 219 KGIKVTVVCP 228
>At2g29340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 85.5 bits (210), Expect = 3e-16
Identities = 60/229 (26%), Positives = 111/229 (48%), Gaps = 16/229 (6%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP--SAVVDEINKK-YGSGSAVA 366
SL+G ++TG SG+G + + A +GA++ + DI + + + E KK + +V
Sbjct: 6 SLKGMTALVTGGASGIGYAIVEELAGFGARIHVCDISEAKLNQSLSEWEKKGFQVSGSVC 65
Query: 367 DTHDIVKEAQQVVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
D E ++++QT +F G+++ILV+N G++R + + TED++ I+ ++ + +
Sbjct: 66 DVASR-PEREELMQTVSSQFDGKLNILVSNVGVIRSKPTTEYTEDDFAFHISSNVEAAYH 124
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
S+ P+ G II +S +G+ Y K A++ ++ LA E K GI
Sbjct: 125 FSQLSHPLLKASGYGSIIFVSSIAGVISFDAGSIYGLTKGALIQLAKNLACEWAKDGIRA 184
Query: 486 NVIAPHA-----------ETAMTKTIFSSKELNNHFDPGFVSPFVVLLC 523
N +AP+ + + K + S L +P V+ V LC
Sbjct: 185 NAVAPNVINTPLSQSYLEDVSFKKALLSRTPLGRVGEPNEVASLVAFLC 233
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/182 (24%), Positives = 84/182 (45%), Gaps = 1/182 (0%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
K ++TG G+G E A G ++ V D+ + + + E +K G +
Sbjct: 8 KGMTALVTGGASGIGYAIVEELAGFGARIHVCDISEAKLNQSLSEWEKKGFQVSGSVCDV 67
Query: 66 SVSDNGAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTR 124
+ +++T S F G+++IL++N G++R + +E F I ++ A+ ++
Sbjct: 68 ASRPEREELMQTVSSQFDGKLNILVSNVGVIRSKPTTEYTEDDFAFHISSNVEAAYHFSQ 127
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSI 184
+ P ++ +G II S AG+ + Y K L+ ++LA E K I N++
Sbjct: 128 LSHPLLKASGYGSIIFVSSIAGVISFDAGSIYGLTKGALIQLAKNLACEWAKDGIRANAV 187
Query: 185 AP 186
AP
Sbjct: 188 AP 189
>At1g07440 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 266
Score = 85.5 bits (210), Expect = 3e-16
Identities = 64/228 (28%), Positives = 107/228 (46%), Gaps = 15/228 (6%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT- 368
SL+ K V++TG G+G + + FA +GA V+ R+ + + ++K G V +
Sbjct: 11 SLKAKTVLVTGGTKGIGHAIVEEFAGFGA-VIHTCARNEYELNECLSKWQKKGFQVTGSV 69
Query: 369 --HDIVKEAQQVVQTAVDKFG-RVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
+ E ++++QT FG ++DIL+NN G +R + T ++++ I+ +L S +
Sbjct: 70 CDASLRPEREKLMQTVSSMFGGKLDILINNLGAIRSKPTLDYTAEDFSFHISTNLESAYH 129
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
LS+ P+ G II +S +G+ Y+A K A+ +R LA E GI
Sbjct: 130 LSQLAHPLLKASGCGNIIFMSSIAGVVSASVGSIYSATKGALNQLARNLACEWASDGIRA 189
Query: 486 NVIAPHA----------ETAMTKTIFSSKELNNHFDPGFVSPFVVLLC 523
N +AP + K + S K L +P VS V LC
Sbjct: 190 NAVAPAVIATPLAEAVYDDEFKKVVISRKPLGRFGEPEEVSSLVAFLC 237
Score = 64.7 bits (156), Expect = 6e-10
Identities = 59/224 (26%), Positives = 97/224 (42%), Gaps = 12/224 (5%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
K + V++TG G+G E+A G + + + + +K G +
Sbjct: 13 KAKTVLVTGGTKGIGHAIVEEFAGFGAVIHTCARNEYELNECLSKWQKKGFQVTGSVCDA 72
Query: 66 SVSDNGAAIVETAISNFG-RVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTR 124
S+ +++T S FG ++DILINN G +R + + F I +L A+ L++
Sbjct: 73 SLRPEREKLMQTVSSMFGGKLDILINNLGAIRSKPTLDYTAEDFSFHISTNLESAYHLSQ 132
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSI 184
A P ++ G II S AG+ + YSA K L +LA E I N++
Sbjct: 133 LAHPLLKASGCGNIIFMSSIAGVVSASVGSIYSATKGALNQLARNLACEWASDGIRANAV 192
Query: 185 A------PLARSAMTEN----VIPANILKELG-PEKIAPLILYL 217
A PLA + + VI L G PE+++ L+ +L
Sbjct: 193 APAVIATPLAEAVYDDEFKKVVISRKPLGRFGEPEEVSSLVAFL 236
>At3g42960 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 272
Score = 85.1 bits (209), Expect = 4e-16
Identities = 63/187 (33%), Positives = 96/187 (50%), Gaps = 9/187 (4%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
K L KV IITG G+G + A+ F GA V++ DI + ++ + + G
Sbjct: 6 KRLFEKVAIITGGARGIGAATARLFTENGAYVIVADILENEGIL--VAESIGGCYVHC-- 61
Query: 369 HDIVKEA--QQVVQTAVDKFGRVDILVNNAGI-LRDRSFAKMTEDEWNAVINVHLFSTF- 424
D+ KEA + V+ A+ + GR+D++ NNAG+ L + S M D N +++V++
Sbjct: 62 -DVSKEADVEAAVELAMRRKGRLDVMFNNAGMSLNEGSIMGMDVDMVNKLVSVNVNGVLH 120
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
+ A + + G II T+S+SG+ G G Y +K AI G RT A E GI
Sbjct: 121 GIKHAAKAMIKGGRGGSIICTSSSSGLMGGLGGHAYTLSKGAINGVVRTTACELGSHGIR 180
Query: 485 VNVIAPH 491
VN I+PH
Sbjct: 181 VNSISPH 187
Score = 72.8 bits (177), Expect = 2e-12
Identities = 56/183 (30%), Positives = 89/183 (48%), Gaps = 9/183 (4%)
Query: 7 DRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD- 65
++V IITG G+G A + + G V+V D+ + V + I G + D
Sbjct: 10 EKVAIITGGARGIGAATARLFTENGAYVIVADILENEGILVAESI------GGCYVHCDV 63
Query: 66 SVSDNGAAIVETAISNFGRVDILINNAGI-LRDSSFAKMSEKQFQQVIDVHLNGAFK-LT 123
S + A VE A+ GR+D++ NNAG+ L + S M +++ V++NG +
Sbjct: 64 SKEADVEAAVELAMRRKGRLDVMFNNAGMSLNEGSIMGMDVDMVNKLVSVNVNGVLHGIK 123
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNS 183
AA ++ + G II T S +GL G G Y+ +K + G + A E + I VNS
Sbjct: 124 HAAKAMIKGGRGGSIICTSSSSGLMGGLGGHAYTLSKGAINGVVRTTACELGSHGIRVNS 183
Query: 184 IAP 186
I+P
Sbjct: 184 ISP 186
>CE21093 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 281
Score = 84.7 bits (208), Expect = 6e-16
Identities = 59/194 (30%), Positives = 95/194 (48%), Gaps = 9/194 (4%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA 60
M F +V ++TG+ G+GR A+ +AK G KV V + QEI K G
Sbjct: 1 MLSRFSGKVALVTGSSNGIGRAAAVLFAKDGAKVTVTGRNAERLEETRQEILKSGVPESH 60
Query: 61 VANY--DSVSDNGA-AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ----FQQVID 113
V + D ++ G +V + I FGR+DIL+NNAG + ++ Q + +++
Sbjct: 61 VLSVATDLAAEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDKIMQ 120
Query: 114 VHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAG-LYGNFGQANYSAAKLGLLGFGESLAK 172
+++ LT+ A H+ K K G I+N S AG + G Y+ +K L F A
Sbjct: 121 INMRSVVTLTQKAKEHLVKAK-GEIVNVSSIAGTAHAQPGVMYYAMSKSALDQFTRCAAI 179
Query: 173 EGYKYNINVNSIAP 186
+ +Y + VNS++P
Sbjct: 180 DLIQYGVRVNSVSP 193
Score = 79.3 bits (194), Expect = 2e-14
Identities = 59/195 (30%), Positives = 106/195 (54%), Gaps = 17/195 (8%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTH--- 369
GKV ++TGS +G+G++ A FA+ GAKV + R+ + + + SG V ++H
Sbjct: 7 GKVALVTGSSNGIGRAAAVLFAKDGAKVTVTG-RNAERLEETRQEILKSG--VPESHVLS 63
Query: 370 ---DIVKEAQQ--VVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDE----WNAVINVHL 420
D+ E Q +V + + KFGR+DILVNNAG + ++ D+ ++ ++ +++
Sbjct: 64 VATDLAAEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDKIMQINM 123
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSG-IYGNFGQCNYAAAKAAILGFSRTLALEGT 479
S L++ +K K G I+N +S +G + G YA +K+A+ F+R A++
Sbjct: 124 RSVVTLTQKAKEHLVKAK-GEIVNVSSIAGTAHAQPGVMYYAMSKSALDQFTRCAAIDLI 182
Query: 480 KRGITVNVIAPHAET 494
+ G+ VN ++P T
Sbjct: 183 QYGVRVNSVSPGGVT 197
>CE19894 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 84.7 bits (208), Expect = 6e-16
Identities = 66/255 (25%), Positives = 124/255 (47%), Gaps = 22/255 (8%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA-VAN 63
F+ +V I+T A G+G A G VV+ + D ++ +K G A +A
Sbjct: 8 FEGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAG 67
Query: 64 YDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFA---KMSEKQFQQVIDVHLNGAF 120
+ + +D+ +V+ + FG+++IL+NN GI + +F ++S++ + ++ +V++ F
Sbjct: 68 HIASTDDQKKLVDFTLQKFGKINILVNNHGI--NPAFGHILEVSDQVWDKLFEVNVKAGF 125
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
++T+ PH+ K+ G II S + G A Y K L+G +LA K NI
Sbjct: 126 QMTKLVHPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIR 185
Query: 181 VNSIAP-LARSAMTENV-------------IPANILKELG-PEKIAPLILYLTHENTK-V 224
VN IAP + ++ M++ + I L LG P+ A + YL +++ +
Sbjct: 186 VNGIAPGVIKTKMSQVLWDGGEDAEKELTDIQEIALGRLGVPDDCAGTVAYLASDDSSYI 245
Query: 225 TNNIFELAAGFYSQI 239
T + +A G +++
Sbjct: 246 TGEMIIIAGGVQARL 260
Score = 79.0 bits (193), Expect = 3e-14
Identities = 63/214 (29%), Positives = 102/214 (47%), Gaps = 21/214 (9%)
Query: 305 PIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDE---------I 355
P + GKV I+T + G+G + A+ GA VVI + VDE +
Sbjct: 2 PSNCRRFEGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKN--VDEAIEYLKNKGL 59
Query: 356 NKKYGSGSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFA---KMTEDEW 412
K G +A T D +++V + KFG+++ILVNN GI + +F ++++ W
Sbjct: 60 TKVAGIAGHIASTDD----QKKLVDFTLQKFGKINILVNNHGI--NPAFGHILEVSDQVW 113
Query: 413 NAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSR 472
+ + V++ + F ++K V P K+ G II S S G Y K ++G +R
Sbjct: 114 DKLFEVNVKAGFQMTKLVHPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTR 173
Query: 473 TLALEGTKRGITVNVIAPHA-ETAMTKTIFSSKE 505
LA+ K I VN IAP +T M++ ++ E
Sbjct: 174 ALAMGLAKDNIRVNGIAPGVIKTKMSQVLWDGGE 207
>CE06649 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 84.7 bits (208), Expect = 6e-16
Identities = 69/199 (34%), Positives = 99/199 (49%), Gaps = 26/199 (13%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA---- 60
F +VV+I+G+ G+G+ A+++A G K+V+N GRSA D V++ +KL E A
Sbjct: 6 FSGKVVLISGSSKGIGQATAVKFAAEGAKIVLN--GRSADD--VEKTRKLCMEVGAKPWD 61
Query: 61 -------VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVID 113
+ N D V +V T I NFG++DILINNAG L K + V+D
Sbjct: 62 LLPTVGDITNEDFVK----MMVNTVIHNFGKLDILINNAGTLEVDMTGKEGWEMGVDVMD 117
Query: 114 VHLNGAFK----LTRAAWPHMRKQKFGRIIN--TCSPAGLYGNFGQANYSAAKLGLLGFG 167
N FK LT+AA PH+ K K G I+N T +G G Y+ K L
Sbjct: 118 RSWNSNFKSVLMLTQAAMPHLIKTK-GDIVNVSTFLSSGPIGVMSMPYYAVPKAALDQMS 176
Query: 168 ESLAKEGYKYNINVNSIAP 186
S+A E + +N++ P
Sbjct: 177 RSMAHEYMLKGVRLNTVNP 195
Score = 82.4 bits (202), Expect = 3e-15
Identities = 62/197 (31%), Positives = 96/197 (48%), Gaps = 14/197 (7%)
Query: 306 IPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVIN-----DIRDPSAVVDEINKKYG 360
+P GKVV+I+GS G+G++ A FA GAK+V+N D+ + E+ K
Sbjct: 1 MPGTRFSGKVVLISGSSKGIGQATAVKFAAEGAKIVLNGRSADDVEKTRKLCMEVGAK-- 58
Query: 361 SGSAVADTHDIVKE--AQQVVQTAVDKFGRVDILVNNAGILRDRSFAK----MTEDEWNA 414
+ DI E + +V T + FG++DIL+NNAG L K M D +
Sbjct: 59 PWDLLPTVGDITNEDFVKMMVNTVIHNFGKLDILINNAGTLEVDMTGKEGWEMGVDVMDR 118
Query: 415 VINVHLFSTFALSKAVWPIFLKQKSGYI-INTTSTSGIYGNFGQCNYAAAKAAILGFSRT 473
N + S L++A P +K K + ++T +SG G YA KAA+ SR+
Sbjct: 119 SWNSNFKSVLMLTQAAMPHLIKTKGDIVNVSTFLSSGPIGVMSMPYYAVPKAALDQMSRS 178
Query: 474 LALEGTKRGITVNVIAP 490
+A E +G+ +N + P
Sbjct: 179 MAHEYMLKGVRLNTVNP 195
>Hs20373187 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 231
Score = 84.3 bits (207), Expect = 7e-16
Identities = 55/192 (28%), Positives = 103/192 (53%), Gaps = 6/192 (3%)
Query: 305 PIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDI-RDPSAVVDEINKKYGSGS 363
P P K++ G++V+ITG+GSGLG+ A FAR G+ +V+ DI ++ + ++ ++ G+
Sbjct: 32 PKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATR 91
Query: 364 AVADTHDIVKE--AQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
A T D ++ +V + G V IL+NNAGI+ + F ++ +V+
Sbjct: 92 VHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFK 151
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE---G 478
+ KA P + G+++ +S++G+ G G +Y A+K A GF+ ++ +E
Sbjct: 152 AHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQ 211
Query: 479 TKRGITVNVIAP 490
++GI ++ P
Sbjct: 212 KQKGIKTTIVCP 223
Score = 82.8 bits (203), Expect = 2e-15
Identities = 51/168 (30%), Positives = 80/168 (47%), Gaps = 1/168 (0%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVS 68
+V+ITGAG GLGR+ AL++A+ G +V+ D+ + + + ++ G D
Sbjct: 42 IVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQ 101
Query: 69 DNGA-AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAW 127
G + + G V ILINNAGI+ F ++ ++ DV+ +A
Sbjct: 102 KEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFL 161
Query: 128 PHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGY 175
P M G ++ S AGL G G A+Y A+K GF ES+ E +
Sbjct: 162 PAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETF 209
>Hs20149619 [Q] KOG1205 Predicted dehydrogenase
Length = 325
Score = 84.3 bits (207), Expect = 7e-16
Identities = 66/192 (34%), Positives = 94/192 (48%), Gaps = 16/192 (8%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVV------------INDIRDPSAVVDEINKK 358
LR VV+ITG+ SGLGK A+ F GAK+V I ++ A + +K
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
Query: 359 YGSGSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINV 418
Y + D+ IV A +++Q FG VDILVNNAGI + T D V+
Sbjct: 110 YLVTFDLTDSGAIVAAAAEILQC----FGYVDILVNNAGISYRGTIMDTTVDVDKRVMET 165
Query: 419 HLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEG 478
+ F AL+KA+ P +K++ G+I+ +S G + YAA+K A F L E
Sbjct: 166 NYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEM 225
Query: 479 TKRGITVNVIAP 490
+ I V VI+P
Sbjct: 226 EQYEIEVTVISP 237
Score = 73.6 bits (179), Expect = 1e-12
Identities = 55/188 (29%), Positives = 94/188 (49%), Gaps = 8/188 (4%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIK-----KLGGEGDA 60
++ VV+ITGA GLG+ A + G K+V+ A + +++E+ K+
Sbjct: 51 RNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPY 110
Query: 61 VANYDSVSDNGAAIVETA--ISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNG 118
+ +D ++D+GA + A + FG VDIL+NNAGI + + ++V++ + G
Sbjct: 111 LVTFD-LTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFG 169
Query: 119 AFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYN 178
LT+A P M K++ G I+ S G ++ Y+A+K F + L E +Y
Sbjct: 170 PVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYE 229
Query: 179 INVNSIAP 186
I V I+P
Sbjct: 230 IEVTVISP 237
>At2g47130 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 84.3 bits (207), Expect = 7e-16
Identities = 61/186 (32%), Positives = 98/186 (51%), Gaps = 6/186 (3%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP--SAVVDEINKKYGSGSAVADT 368
L GK+ IITG SG+G + F +GAKVVI D ++ V + K S T
Sbjct: 6 LDGKIAIITGGASGIGAEAVRLFTDHGAKVVIVDFQEELGQNVAVSVGKDKASFYRCDVT 65
Query: 369 HDIVKEAQQVVQTAVDKFGRVDILVNNAGIL-RDRSFAKMTEDEWNAVINVHLFSTFALS 427
++ KE + V+ V+K+G++D+L +NAG++ + SF + ++++ + V++ A
Sbjct: 66 NE--KEVENAVKFTVEKYGKLDVLFSNAGVMEQPGSFLDLNLEQFDRTMAVNVRGAAAFI 123
Query: 428 K-AVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
K A + K G I+ TTS + G G Y A+K A+LG ++ K GI VN
Sbjct: 124 KHAARAMVEKGTRGSIVCTTSVASEIGGPGPHAYTASKHALLGLVKSACGGLGKYGIRVN 183
Query: 487 VIAPHA 492
+AP+A
Sbjct: 184 GVAPYA 189
Score = 75.5 bits (184), Expect = 3e-13
Identities = 56/191 (29%), Positives = 88/191 (45%), Gaps = 10/191 (5%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVA 62
L ++ IITG G+G + G KVV+ D +V + K D +
Sbjct: 4 LRLDGKIAIITGGASGIGAEAVRLFTDHGAKVVIVDFQEELGQNVAVSVGK-----DKAS 58
Query: 63 NYDSVSDNGAAI---VETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVHLNG 118
Y N + V+ + +G++D+L +NAG++ SF ++ +QF + + V++ G
Sbjct: 59 FYRCDVTNEKEVENAVKFTVEKYGKLDVLFSNAGVMEQPGSFLDLNLEQFDRTMAVNVRG 118
Query: 119 AFKLTR-AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
A + AA + K G I+ T S A G G Y+A+K LLG +S KY
Sbjct: 119 AAAFIKHAARAMVEKGTRGSIVCTTSVASEIGGPGPHAYTASKHALLGLVKSACGGLGKY 178
Query: 178 NINVNSIAPLA 188
I VN +AP A
Sbjct: 179 GIRVNGVAPYA 189
>At1g54870 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 84.3 bits (207), Expect = 7e-16
Identities = 65/207 (31%), Positives = 106/207 (50%), Gaps = 15/207 (7%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVIN--------DIRDPSAVVDEINKKYGSGSAV 365
+V +ITG SG+G++ FA GA V D ++ ++ E+ K S +
Sbjct: 36 RVALITGGDSGIGRAVGYCFASEGATVAFTYVKGQEEKDAQETLQMLKEV-KTSDSKEPI 94
Query: 366 ADTHDIV--KEAQQVVQTAVDKFGRVDILVNNAGILRDRS-FAKMTEDEWNAVINVHLFS 422
A D+ + ++VV V+ FGR+D+L+NNA + S ++ E V ++FS
Sbjct: 95 AIPTDLGFDENCKRVVDEVVNAFGRIDVLINNAAEQYESSTIEEIDEPRLERVFRTNIFS 154
Query: 423 TFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
F L++ +K+ S IINTTS + GN +Y A K AI+ F+R LAL+ ++G
Sbjct: 155 YFFLTRHALK-HMKEGSS-IINTTSVNAYKGNASLLDYTATKGAIVAFTRGLALQLAEKG 212
Query: 483 ITVNVIAP-HAETAMTKTIFSSKELNN 508
I VN +AP T + F+ +++ N
Sbjct: 213 IRVNGVAPGPIWTPLIPASFNEEKIKN 239
Score = 78.2 bits (191), Expect = 5e-14
Identities = 62/207 (29%), Positives = 98/207 (46%), Gaps = 13/207 (6%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVV---VNDLGRSAADSVVQEIKKL----GGEG 58
K RV +ITG G+GR +A G V V A +Q +K++ E
Sbjct: 34 KLRVALITGGDSGIGRAVGYCFASEGATVAFTYVKGQEEKDAQETLQMLKEVKTSDSKEP 93
Query: 59 DAVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSS-FAKMSEKQFQQVIDVHLN 117
A+ +N +V+ ++ FGR+D+LINNA +SS ++ E + ++V ++
Sbjct: 94 IAIPTDLGFDENCKRVVDEVVNAFGRIDVLINNAAEQYESSTIEEIDEPRLERVFRTNIF 153
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
F LTR A HM++ IINT S GN +Y+A K ++ F LA + +
Sbjct: 154 SYFFLTRHALKHMKEGS--SIINTTSVNAYKGNASLLDYTATKGAIVAFTRGLALQLAEK 211
Query: 178 NINVNSIAPLARSAMTENVIPANILKE 204
I VN +AP + +IPA+ +E
Sbjct: 212 GIRVNGVAP---GPIWTPLIPASFNEE 235
>At5g50700 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 84.0 bits (206), Expect = 1e-15
Identities = 56/168 (33%), Positives = 92/168 (54%), Gaps = 3/168 (1%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD-S 66
+VV+ITGA G+G A EYA RG + + ++ + V + ++LG + D S
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVS 107
Query: 67 VSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSE-KQFQQVIDVHLNGAFKLTRA 125
D+ IV+ I++FGR+D L+NNAG+ + S F + + + + V+D + G+ TRA
Sbjct: 108 KPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSVYTTRA 167
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
A P++R Q G+I+ S A + Y+A+K LL F E++ E
Sbjct: 168 ALPYLR-QSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIE 214
Score = 78.2 bits (191), Expect = 5e-14
Identities = 65/225 (28%), Positives = 117/225 (51%), Gaps = 11/225 (4%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIR-DPSAVVDEINKKYGSGSAVAD 367
++L GKVV+ITG+ SG+G+ A +A GA + + R + V EI ++ GS + V
Sbjct: 43 ENLYGKVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTV 102
Query: 368 THDIVK--EAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTE-DEWNAVINVHLFSTF 424
D+ K + +++V + FGR+D LVNNAG+ + F + + AV++ + + +
Sbjct: 103 HADVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSV 162
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
++A P +L+Q +G I+ +S++ Y A+KAA+L F T+ +E +
Sbjct: 163 YTTRAALP-YLRQSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIE-LGGDVH 220
Query: 485 VNVIAP-HAETAMTKTIFSSKE----LNNHFDPGFVSPFVVLLCS 524
+ ++ P + E+ +T+ + S E +N V PF V S
Sbjct: 221 ITIVTPGYIESELTQGKYFSGEGELIVNQDMRDVQVGPFPVASAS 265
>At5g50600 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 84.0 bits (206), Expect = 1e-15
Identities = 56/168 (33%), Positives = 92/168 (54%), Gaps = 3/168 (1%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD-S 66
+VV+ITGA G+G A EYA RG + + ++ + V + ++LG + D S
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVS 107
Query: 67 VSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSE-KQFQQVIDVHLNGAFKLTRA 125
D+ IV+ I++FGR+D L+NNAG+ + S F + + + + V+D + G+ TRA
Sbjct: 108 KPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSVYTTRA 167
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
A P++R Q G+I+ S A + Y+A+K LL F E++ E
Sbjct: 168 ALPYLR-QSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIE 214
Score = 78.2 bits (191), Expect = 5e-14
Identities = 65/225 (28%), Positives = 117/225 (51%), Gaps = 11/225 (4%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIR-DPSAVVDEINKKYGSGSAVAD 367
++L GKVV+ITG+ SG+G+ A +A GA + + R + V EI ++ GS + V
Sbjct: 43 ENLYGKVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTV 102
Query: 368 THDIVK--EAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTE-DEWNAVINVHLFSTF 424
D+ K + +++V + FGR+D LVNNAG+ + F + + AV++ + + +
Sbjct: 103 HADVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSV 162
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
++A P +L+Q +G I+ +S++ Y A+KAA+L F T+ +E +
Sbjct: 163 YTTRAALP-YLRQSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIE-LGGDVH 220
Query: 485 VNVIAP-HAETAMTKTIFSSKE----LNNHFDPGFVSPFVVLLCS 524
+ ++ P + E+ +T+ + S E +N V PF V S
Sbjct: 221 ITIVTPGYIESELTQGKYFSGEGELIVNQDMRDVQVGPFPVASAS 265
>Hs7705907 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 83.2 bits (204), Expect = 2e-15
Identities = 59/184 (32%), Positives = 96/184 (52%), Gaps = 14/184 (7%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPS---AVVDEINKKYGSGSAVADTH 369
GKVV++TG G G+G + F GA+VVI D +D S A+ E+ AV
Sbjct: 9 GKVVVVTGGGRGIGAGIVRAFVNSGARVVICD-KDESGGRALEQELP------GAVFILC 61
Query: 370 DIVKE--AQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDE-WNAVINVHLFSTFAL 426
D+ +E + +V + +FGR+D +VNNAG + T + + ++ ++L T+ L
Sbjct: 62 DVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTL 121
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
+K P +L++ G +IN +S G G Y A K A+ ++ LAL+ + G+ VN
Sbjct: 122 TKLALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180
Query: 487 VIAP 490
I+P
Sbjct: 181 CISP 184
Score = 81.3 bits (199), Expect = 6e-15
Identities = 54/184 (29%), Positives = 91/184 (49%), Gaps = 8/184 (4%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANY 64
+ +VV++TG G G+G + G +VV+ D S ++ QE+ G
Sbjct: 7 YAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL-----PGAVFILC 61
Query: 65 D-SVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ-FQQVIDVHLNGAFKL 122
D + D+ +V I FGR+D ++NNAG + + Q F+Q+++++L G + L
Sbjct: 62 DVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTL 121
Query: 123 TRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVN 182
T+ A P++RK + G +IN S G G Y A K + ++LA + Y + VN
Sbjct: 122 TKLALPYLRKSQ-GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180
Query: 183 SIAP 186
I+P
Sbjct: 181 CISP 184
>Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 310
Score = 82.8 bits (203), Expect = 2e-15
Identities = 61/239 (25%), Positives = 109/239 (45%), Gaps = 4/239 (1%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
+ITGAG G+G+ Y+ E AKRG VV+ +++ EI++ G + D D+
Sbjct: 52 VITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDD 111
Query: 71 GAAIVETAISNFGRVDILINNAGILRD--SSFAKMSEKQFQQVIDVHLNGAFKLTRAAWP 128
++ ++ + IL+NN G+L + S + + Q +I ++ K+T+
Sbjct: 112 IYEHIKEKLAGL-EIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILK 170
Query: 129 HMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAPLA 188
HM ++ G I+N S L+ + YSA+K + F ++L +E + + + P A
Sbjct: 171 HMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYA 230
Query: 189 RSAMTENVIPANILKELGPEKIAPLILYLTHENTKVTNNIFELAAGFYSQI-RWERSSG 246
S + N++ + E + + Y+T E+ AGF S I W SG
Sbjct: 231 VSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSG 289
Score = 64.7 bits (156), Expect = 6e-10
Identities = 60/243 (24%), Positives = 111/243 (44%), Gaps = 30/243 (12%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVI--NDIRDPSAVVDEINKKYGSGSAVADTHD 370
G+ +ITG+G G+GK+++ A+ G VV+ + A+ EI + G + D
Sbjct: 48 GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQA-D 106
Query: 371 IVKEAQQVVQTAVDKFG--RVDILVNNAGILRD--RSFAKMTEDEWNAVINVHLFSTFAL 426
K+ + + +K + ILVNN G+L + S DE ++I+ ++ S +
Sbjct: 107 FTKD--DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKM 164
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
++ + ++ G I+N +S ++ Y+A+KA + FS+ L E + + +
Sbjct: 165 TQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQ 224
Query: 487 VIAPHA-ETAMTKTIFSSKELNNHFDPGFVSPFVVLLCSDELQELGKNRVKGLLFEVGGG 545
V+ P+A TAMTK +++ V+ +DE + N V +GG
Sbjct: 225 VLTPYAVSTAMTK---------------YLNTNVITKTADEFVKESLNYV-----TIGGE 264
Query: 546 WCG 548
CG
Sbjct: 265 TCG 267
>7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 320
Score = 82.8 bits (203), Expect = 2e-15
Identities = 53/187 (28%), Positives = 97/187 (51%), Gaps = 10/187 (5%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPS--AVVDEIN----KKYG 360
P+ + GKVV+ITG+G G+GK A +A+ GA ++ D+ + + V EI K +G
Sbjct: 52 PLDDVNGKVVLITGTGHGMGKEMALQYAKLGATILCWDVNEQTNNQTVKEIKNNGGKAFG 111
Query: 361 SGSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHL 420
V ++++ AQ+V + + G + ++VNNAGI+ + TE+E + +++
Sbjct: 112 YVCNVTKREELIELAQKVRK----EHGFIHVVVNNAGIMPCHPLLEHTENEIRLMYEINV 167
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTK 480
S F + +A P +++ G I+ +S +G++G Y K A+ G+ L E +
Sbjct: 168 LSHFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAALVEELRQ 227
Query: 481 RGITVNV 487
+ NV
Sbjct: 228 KNPQNNV 234
Score = 78.6 bits (192), Expect = 4e-14
Identities = 47/183 (25%), Positives = 90/183 (48%), Gaps = 4/183 (2%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+VV+ITG G G+G+ AL+YAK G ++ D+ + V+EIK GG+ +
Sbjct: 59 KVVLITGTGHGMGKEMALQYAKLGATILCWDVNEQTNNQTVKEIKNNGGKAFGYVCNVTK 118
Query: 68 SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAW 127
+ + + G + +++NNAGI+ + +E + + + ++++ F + +A
Sbjct: 119 REELIELAQKVRKEHGFIHVVVNNAGIMPCHPLLEHTENEIRLMYEINVLSHFWIIQAFL 178
Query: 128 PHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGF----GESLAKEGYKYNINVNS 183
P M ++ G I+ S AGL+G Y K + G+ E L ++ + N+ + +
Sbjct: 179 PDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAALVEELRQKNPQNNVKLTT 238
Query: 184 IAP 186
I P
Sbjct: 239 IYP 241
>Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 261
Score = 82.4 bits (202), Expect = 3e-15
Identities = 68/194 (35%), Positives = 93/194 (47%), Gaps = 17/194 (8%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGD-AVANY 64
K V +ITG GLG A +G V+ DL S ++ + KKLG A A+
Sbjct: 9 KGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEA---QAKKLGNNCVFAPADV 65
Query: 65 DSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ------FQQVIDVHLNG 118
S D A+ A FGRVD+ +N AGI S + + Q FQ+V+DV+L G
Sbjct: 66 TSEKDVQTALA-LAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMG 124
Query: 119 AFKLTRAAWPHMRKQK------FGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAK 172
F + R M + + G IINT S A G GQA YSA+K G++G +A+
Sbjct: 125 TFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIAR 184
Query: 173 EGYKYNINVNSIAP 186
+ I V +IAP
Sbjct: 185 DLAPIGIRVMTIAP 198
Score = 81.3 bits (199), Expect = 6e-15
Identities = 63/196 (32%), Positives = 97/196 (49%), Gaps = 17/196 (8%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
+S++G V +ITG SGLG + A+ GA V+ D+ P++ + KK G+ A
Sbjct: 6 RSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDL--PNSGGEAQAKKLGNNCVFAPA 63
Query: 369 HDIV--KEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKM------TEDEWNAVINVHL 420
D+ K+ Q + A KFGRVD+ VN AGI + T +++ V++V+L
Sbjct: 64 -DVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
Query: 421 FSTFALSKAVWPIFLKQKS------GYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTL 474
TF + + V + + G IINT S + G GQ Y+A+K I+G + +
Sbjct: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
Query: 475 ALEGTKRGITVNVIAP 490
A + GI V IAP
Sbjct: 183 ARDLAPIGIRVMTIAP 198
>At2g29330 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 82.0 bits (201), Expect = 4e-15
Identities = 69/230 (30%), Positives = 111/230 (48%), Gaps = 18/230 (7%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP--SAVVDEINKK--YGSGSAV 365
SL+G ++TG SG+G + + A +GAK+ + DI + + E KK SGS
Sbjct: 6 SLQGLTALVTGGASGIGHAIVEELAGFGAKIHVCDISKTLLNQSLSEWEKKGFQVSGSVC 65
Query: 366 ADTHDIVKEA-QQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTF 424
++ + +E Q V T D G+++ILVNN G +R + + ++++ +I+ +L S +
Sbjct: 66 DASNRLERETLMQTVTTIFD--GKLNILVNNVGTIRTKPTIEYEAEDFSFLISTNLESAY 123
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
LS+ P+ +G I +S +GI Y K A+ +R LA E K GI
Sbjct: 124 HLSQLSHPLLKASGNGIITFISSAAGIVSFDAASIYGLTKGALNQLARNLACEWAKDGIR 183
Query: 485 VNVIAPH-AETAMTK---------TIFSSK-ELNNHFDPGFVSPFVVLLC 523
N +AP+ TA+ K I SS+ L +P V+ V LC
Sbjct: 184 ANAVAPNFITTALAKPFLEDAGFNEILSSRTPLGRAGEPREVASLVAFLC 233
Score = 63.5 bits (153), Expect = 1e-09
Identities = 45/177 (25%), Positives = 80/177 (44%), Gaps = 1/177 (0%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TG G+G E A G K+ V D+ ++ + + E +K G + S
Sbjct: 13 LVTGGASGIGHAIVEELAGFGAKIHVCDISKTLLNQSLSEWEKKGFQVSGSVCDASNRLE 72
Query: 71 GAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
+++T + F G+++IL+NN G +R + + F +I +L A+ L++ + P
Sbjct: 73 RETLMQTVTTIFDGKLNILVNNVGTIRTKPTIEYEAEDFSFLISTNLESAYHLSQLSHPL 132
Query: 130 MRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
++ G I S AG+ + Y K L +LA E K I N++AP
Sbjct: 133 LKASGNGIITFISSAAGIVSFDAASIYGLTKGALNQLARNLACEWAKDGIRANAVAP 189
>At2g29320 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 82.0 bits (201), Expect = 4e-15
Identities = 65/232 (28%), Positives = 112/232 (48%), Gaps = 21/232 (9%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP---SAVVDEINKKYGSGSAVA 366
SL+G ++TG+ SG+G + + A +GAK+ I DI ++ + NK + +V
Sbjct: 12 SLQGMTALVTGAASGIGYAIVEELAGFGAKIHICDISKTLLNQSLSEWENKGFQVSGSVC 71
Query: 367 D--THDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTF 424
D +H ++ Q V + D G+++ILVNN G+LR + + D++ I+ +L + +
Sbjct: 72 DVTSHPEREKLMQTVSSIFD--GKLNILVNNVGVLRGKPTTEYVADDFTFHISTNLEAAY 129
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCN--YAAAKAAILGFSRTLALEGTKRG 482
+ P+ G I+ +S +G+ + C Y K A+ +R LA E K G
Sbjct: 130 HFCQLSHPLLKASGYGSIVFLSSVAGVV-SLIDCGSIYGLTKGALNQLARNLACEWAKDG 188
Query: 483 ITVNVIAPH-AETAMTKT----------IFSSKELNNHFDPGFVSPFVVLLC 523
I N +AP+ +TA +++ + S L +P VS VV LC
Sbjct: 189 IRANAVAPNVVKTAQSQSFLEDVSKKEGLLSRTPLGRVGEPNEVSSLVVFLC 240
Score = 61.2 bits (147), Expect = 7e-09
Identities = 52/221 (23%), Positives = 100/221 (44%), Gaps = 14/221 (6%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TGA G+G E A G K+ + D+ ++ + + E + G + +
Sbjct: 19 LVTGAASGIGYAIVEELAGFGAKIHICDISKTLLNQSLSEWENKGFQVSGSVCDVTSHPE 78
Query: 71 GAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
+++T S F G+++IL+NN G+LR + F I +L A+ + + P
Sbjct: 79 REKLMQTVSSIFDGKLNILVNNVGVLRGKPTTEYVADDFTFHISTNLEAAYHFCQLSHPL 138
Query: 130 MRKQKFGRIINTCSPAGLYGNFGQAN-YSAAKLGLLGFGESLAKEGYKYNINVNSIAP-L 187
++ +G I+ S AG+ + Y K L +LA E K I N++AP +
Sbjct: 139 LKASGYGSIVFLSSVAGVVSLIDCGSIYGLTKGALNQLARNLACEWAKDGIRANAVAPNV 198
Query: 188 ARSAMTENVIPANILKE-------LG----PEKIAPLILYL 217
++A +++ + KE LG P +++ L+++L
Sbjct: 199 VKTAQSQSFLEDVSKKEGLLSRTPLGRVGEPNEVSSLVVFL 239
>CE27260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 206
Score = 81.6 bits (200), Expect = 5e-15
Identities = 56/185 (30%), Positives = 98/185 (52%), Gaps = 14/185 (7%)
Query: 315 VVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIVKE 374
V I+TG+ SG+G++ A AR K+ + R+ +A+ + + +GS D +D++
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTG-RNVAALNELAGQIVSAGS---DKNDVLVT 58
Query: 375 AQQ---------VVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
A + +V V KFGR+D L+N+AGILR + ++ ++NV++ S
Sbjct: 59 AVELASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYDELMNVNVRSLIR 118
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
L++A P + K G ++N +S +G G Y +K+A+ F++ LALE G+ V
Sbjct: 119 LTRAALPHIITTK-GTVVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVRV 177
Query: 486 NVIAP 490
N + P
Sbjct: 178 NAVCP 182
Score = 80.1 bits (196), Expect = 1e-14
Identities = 59/204 (28%), Positives = 97/204 (46%), Gaps = 12/204 (5%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGE-GDAVANYDSV 67
V I+TGA G+GR AL A+ K+ + +A + + +I G + D + +
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVEL 62
Query: 68 SDNGA--AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRA 125
+ A IV+ + FGR+D LIN+AGILR + + ++++V++ +LTRA
Sbjct: 63 ASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYDELMNVNVRSLIRLTRA 122
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIA 185
A PH+ K G ++N S G G Y +K + F + LA E + VN++
Sbjct: 123 ALPHIITTK-GTVVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVC 181
Query: 186 PLARSAMTENVIPANILKELGPEK 209
P VI NI + G ++
Sbjct: 182 P--------GVIVTNIHRASGQDE 197
>At3g47350 [Q] KOG1205 Predicted dehydrogenase
Length = 308
Score = 81.6 bits (200), Expect = 5e-15
Identities = 55/169 (32%), Positives = 92/169 (53%), Gaps = 5/169 (2%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+VV+ITGA G+G A EYAK+G K+ + + + V + ++L G GD + V
Sbjct: 47 KVVLITGASSGIGEHVAYEYAKKGAKLALVARRKDRLEIVAETSRQL-GSGDVIIIPGDV 105
Query: 68 S--DNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ-FQQVIDVHLNGAFKLTR 124
S ++ ++ I +FG++D LINNAG+ + F ++ Q ++D++ G+ +T
Sbjct: 106 SNVEDCKKFIDETIHHFGKLDHLINNAGVPQTVIFEDFTQIQDANSIMDINFWGSTYITY 165
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
A PH+RK K G+I+ S + + YSA+K L+ F E+L E
Sbjct: 166 FAIPHLRKSK-GKIVVISSATAIIPLQAASVYSASKAALVKFFETLRVE 213
Score = 79.7 bits (195), Expect = 2e-14
Identities = 49/173 (28%), Positives = 101/173 (58%), Gaps = 5/173 (2%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKV-VINDIRDPSAVVDEINKKYGSGSAVAD 367
+++ GKVV+ITG+ SG+G+ A +A+ GAK+ ++ +D +V E +++ GSG +
Sbjct: 42 ENVTGKVVLITGASSGIGEHVAYEYAKKGAKLALVARRKDRLEIVAETSRQLGSGDVIII 101
Query: 368 THDI--VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTE-DEWNAVINVHLFSTF 424
D+ V++ ++ + + FG++D L+NNAG+ + F T+ + N++++++ + +
Sbjct: 102 PGDVSNVEDCKKFIDETIHHFGKLDHLINNAGVPQTVIFEDFTQIQDANSIMDINFWGST 161
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
++ P L++ G I+ +S + I Y+A+KAA++ F TL +E
Sbjct: 162 YITYFAIP-HLRKSKGKIVVISSATAIIPLQAASVYSASKAALVKFFETLRVE 213
>At2g29300 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 263
Score = 81.6 bits (200), Expect = 5e-15
Identities = 61/231 (26%), Positives = 110/231 (47%), Gaps = 19/231 (8%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP---SAVVDEINKKYGSGSAVA 366
SL+G ++TG+ SG+G + + A +GA++ + DI + ++ + K + +V
Sbjct: 6 SLQGMTALVTGAASGIGYAIVEELAGFGARIHVCDISETLLNQSLREWEKKGFQVSGSVC 65
Query: 367 DTHDIVKEAQQVVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
D E ++++QT F G+++ILVNN G+LR + + D++ I+ +L + +
Sbjct: 66 DVTSR-PEREKLMQTVSSLFDGKLNILVNNVGVLRAKPTTEYVADDFTFHISTNLEAAYH 124
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCN--YAAAKAAILGFSRTLALEGTKRGI 483
+ P+ G I+ +S SG+ + C Y K A+ +R LA E K GI
Sbjct: 125 FCQLSHPLLKTSGYGSIVFLSSVSGVV-SITDCGSLYGLTKGALNQLARNLACEWAKDGI 183
Query: 484 TVNVIAPHA-----------ETAMTKTIFSSKELNNHFDPGFVSPFVVLLC 523
N +AP+ + + + +FS L +P V+ VV LC
Sbjct: 184 RANAVAPNVVKTAQSQFFLQDVSKKEGLFSRTPLGRSGEPNEVASLVVFLC 234
Score = 59.7 bits (143), Expect = 2e-08
Identities = 50/221 (22%), Positives = 94/221 (41%), Gaps = 14/221 (6%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TGA G+G E A G ++ V D+ + + ++E +K G + +
Sbjct: 13 LVTGAASGIGYAIVEELAGFGARIHVCDISETLLNQSLREWEKKGFQVSGSVCDVTSRPE 72
Query: 71 GAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
+++T S F G+++IL+NN G+LR + F I +L A+ + + P
Sbjct: 73 REKLMQTVSSLFDGKLNILVNNVGVLRAKPTTEYVADDFTFHISTNLEAAYHFCQLSHPL 132
Query: 130 MRKQKFGRIINTCSPAGLYGNFGQAN-YSAAKLGLLGFGESLAKEGYKYNINVNSIAPLA 188
++ +G I+ S +G+ + Y K L +LA E K I N++AP
Sbjct: 133 LKTSGYGSIVFLSSVSGVVSITDCGSLYGLTKGALNQLARNLACEWAKDGIRANAVAPNV 192
Query: 189 RSAMTENVIPANILKELG------------PEKIAPLILYL 217
++ K+ G P ++A L+++L
Sbjct: 193 VKTAQSQFFLQDVSKKEGLFSRTPLGRSGEPNEVASLVVFL 233
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 81.3 bits (199), Expect = 6e-15
Identities = 59/190 (31%), Positives = 103/190 (54%), Gaps = 13/190 (6%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSG----SAVADTH 369
KV IITGS +G+G++ A+ A GAKV + R+ + + N G+G + +
Sbjct: 7 KVAIITGSSNGIGQATARLLASEGAKVTVTG-RNAERLEETKNILLGAGVPEGNVLVVVG 65
Query: 370 DIVKEAQQ--VVQTAVDKFGRVDILVNNAGI----LRDRSFAKMTEDEWNAVINVHLFST 423
DI +E+ Q ++++ +DKFG++DILVNNAG + +S + D ++ +++ S
Sbjct: 66 DITQESVQENLIKSTLDKFGKIDILVNNAGAGIPDAQGKSGVNQSIDTYHKTFELNVQSV 125
Query: 424 FALSKAVWPIFLKQKSGYIINTTST-SGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
+++ P L + G I+N +S +G Y+ AKAA+ ++RT A++ G
Sbjct: 126 IEMTQKARP-HLAKTQGEIVNISSIGAGPAAQVASPYYSIAKAALDQYTRTAAIDLVPEG 184
Query: 483 ITVNVIAPHA 492
I VN ++P A
Sbjct: 185 IRVNSVSPGA 194
Score = 73.2 bits (178), Expect = 2e-12
Identities = 60/199 (30%), Positives = 96/199 (48%), Gaps = 19/199 (9%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGG---EGDAV 61
F D+V IITG+ G+G+ A A G KV V GR+A + LG EG+ +
Sbjct: 4 FTDKVAIITGSSNGIGQATARLLASEGAKVTVT--GRNAERLEETKNILLGAGVPEGNVL 61
Query: 62 A-----NYDSVSDNGAAIVETAISNFGRVDILINNAGI----LRDSSFAKMSEKQFQQVI 112
+SV +N ++++ + FG++DIL+NNAG + S S + +
Sbjct: 62 VVVGDITQESVQEN---LIKSTLDKFGKIDILVNNAGAGIPDAQGKSGVNQSIDTYHKTF 118
Query: 113 DVHLNGAFKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLA 171
++++ ++T+ A PH+ K + G I+N S AG YS AK L + + A
Sbjct: 119 ELNVQSVIEMTQKARPHLAKTQ-GEIVNISSIGAGPAAQVASPYYSIAKAALDQYTRTAA 177
Query: 172 KEGYKYNINVNSIAPLARS 190
+ I VNS++P A S
Sbjct: 178 IDLVPEGIRVNSVSPGAVS 196
>Hs7706318 [Q] KOG1205 Predicted dehydrogenase
Length = 339
Score = 80.9 bits (198), Expect = 8e-15
Identities = 61/209 (29%), Positives = 102/209 (48%), Gaps = 6/209 (2%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGG--EGDAV 61
E D VV +TGA G+G A + +K G +V++ + V + + G E D +
Sbjct: 47 ELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDIL 106
Query: 62 ANYDSVSDNGA--AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGA 119
++D G+ A + + FGR+DIL+NN G+ + S S ++++I+++ G
Sbjct: 107 VLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGT 166
Query: 120 FKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY-N 178
LT+ PHM ++K G+I+ S G+ Y A+K L GF L E Y
Sbjct: 167 VSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPG 226
Query: 179 INVNSIAP-LARSAMTENVIPANILKELG 206
I V++I P +S + EN + + K +G
Sbjct: 227 IIVSNICPGPVQSNIVENSLAGEVTKTIG 255
Score = 67.4 bits (163), Expect = 9e-11
Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 11/196 (5%)
Query: 304 GPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGS 363
G P L VV +TG+ SG+G+ A ++ G +V++ R ++ + ++
Sbjct: 41 GRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHE--LERVKRRCLENG 98
Query: 364 AVADTHDIVKEA--------QQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAV 415
+ + +V + + + +FGR+DILVNN G+ + + D + +
Sbjct: 99 NLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKL 158
Query: 416 INVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLA 475
I ++ T +L+K V P +++K G I+ S GI Y A+K A+ GF L
Sbjct: 159 IELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLR 218
Query: 476 LE-GTKRGITVNVIAP 490
E T GI V+ I P
Sbjct: 219 TELATYPGIIVSNICP 234
>SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 80.5 bits (197), Expect = 1e-14
Identities = 66/231 (28%), Positives = 114/231 (48%), Gaps = 19/231 (8%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDI---RDPSAVVDEINKKYGSGSAVAD 367
L K ++TG SG+GK+ A FAR G+ +VI+ + RD + V ++ ++ G + +
Sbjct: 40 LAEKKTLLTGGDSGIGKAAAVMFAREGSDLVISCLPEERDDAEVTRDLIEREGRNCWIWE 99
Query: 368 TH-DIVKEAQQVVQTAVDKFGRVDILVNNAGILR-DRSFAKMTEDEWNAVINVHLFSTFA 425
D + +V A+ K G +D+LVNN + +S + +++W+ ++FS F
Sbjct: 100 GKLDKSDNCRDLVDFALKKLGWIDVLVNNIAYQQVAQSIEDIDDEQWDLTFKTNIFSFFW 159
Query: 426 LSKAVWPIFLKQKSGY-IINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
++KA KSG I+N +S + G +Y + K AI F+R L+ + + GI
Sbjct: 160 VTKAA---ISHMKSGSSIVNCSSINAYVGRPDLLDYTSTKGAITAFTRGLSNQYAQHGIR 216
Query: 485 VNVIAP-HAETAMTKTIFSSK--ELNNHFDPG-------FVSPFVVLLCSD 525
VN +AP T + + F + EL++ G S ++ L CSD
Sbjct: 217 VNAVAPGPIYTPLVSSTFPKEKIELSDQVPLGRMGQPVEVASCYLFLACSD 267
Score = 64.3 bits (155), Expect = 8e-10
Identities = 47/184 (25%), Positives = 87/184 (46%), Gaps = 7/184 (3%)
Query: 7 DRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQE--IKKLGGEGDAVANY 64
++ ++TG G+G+ A+ +A+ G +V++ L D+ V I++ G
Sbjct: 42 EKKTLLTGGDSGIGKAAAVMFAREGSDLVISCLPEERDDAEVTRDLIEREGRNCWIWEGK 101
Query: 65 DSVSDNGAAIVETAISNFGRVDILINNAGILR-DSSFAKMSEKQFQQVIDVHLNGAFKLT 123
SDN +V+ A+ G +D+L+NN + S + ++Q+ ++ F +T
Sbjct: 102 LDKSDNCRDLVDFALKKLGWIDVLVNNIAYQQVAQSIEDIDDEQWDLTFKTNIFSFFWVT 161
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLY-GNFGQANYSAAKLGLLGFGESLAKEGYKYNINVN 182
+AA HM K G I CS Y G +Y++ K + F L+ + ++ I VN
Sbjct: 162 KAAISHM---KSGSSIVNCSSINAYVGRPDLLDYTSTKGAITAFTRGLSNQYAQHGIRVN 218
Query: 183 SIAP 186
++AP
Sbjct: 219 AVAP 222
>Hs10190704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 292
Score = 80.5 bits (197), Expect = 1e-14
Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 5/184 (2%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
LR KV ITG GSG+G A+ F R+G VI R V+ K G+
Sbjct: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIAS-RSLPRVLTAARKLAGATGRRCLPLS 84
Query: 371 IVKEAQQVVQTAVDK----FGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFAL 426
+ A V AVD+ FGR+DIL+N A ++ + + V+++ TF +
Sbjct: 85 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNV 144
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
S+ ++ F + G I+N T+T G G Q + +AKAA+ +R LA+E + I VN
Sbjct: 145 SRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVN 204
Query: 487 VIAP 490
+AP
Sbjct: 205 SLAP 208
Score = 67.4 bits (163), Expect = 9e-11
Identities = 62/226 (27%), Positives = 98/226 (42%), Gaps = 14/226 (6%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
+D+V ITG G G+G A + + G V+ + +++ G + D
Sbjct: 27 RDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMD 86
Query: 66 SVSDNGA-AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTR 124
+ A V+ A+ FGR+DILIN A +S F+ V+D+ +G F ++R
Sbjct: 87 VRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSR 146
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSI 184
+ + G I+N + G G Q + +AK + LA E NI VNS+
Sbjct: 147 VLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSL 206
Query: 185 AP--------LAR----SAMTENVIPANILKELGPE-KIAPLILYL 217
AP L R A + A+ L+ LG + +IA +LYL
Sbjct: 207 APGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYL 252
>CE12990 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 80.5 bits (197), Expect = 1e-14
Identities = 61/188 (32%), Positives = 102/188 (53%), Gaps = 13/188 (6%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIV 372
GK VIITGS SG+G++ A FA+ GA+V I + ++ KK D+ ++V
Sbjct: 6 GKSVIITGSSSGIGRATAVLFAKNGAQVTITGRN--AEKLEATKKKLLKVVKTPDSVNVV 63
Query: 373 ----KEAQ---QVVQTAVDKFGRVDILVNNAG--ILRDRSFAKMTEDEWNAVINVHLFST 423
+AQ Q++Q+AV KFG++DIL+NNAG ++ + D ++ ++ +
Sbjct: 64 VANLTDAQGQDQIIQSAVKKFGKIDILINNAGANVVDGTVNTDQSIDLYHKTFQINFQAV 123
Query: 424 FALSKAVWPIFLKQKSGYIINTTS-TSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
+ K ++ K G I+N +S +G YAAAKAA+ ++R +AL+ K+G
Sbjct: 124 VEMVKKTKKYLIESK-GEIVNVSSIAAGPQAVSMSPYYAAAKAALNQYTRCVALDLIKQG 182
Query: 483 ITVNVIAP 490
+ VN ++P
Sbjct: 183 VRVNSVSP 190
Score = 72.4 bits (176), Expect = 3e-12
Identities = 61/240 (25%), Positives = 110/240 (45%), Gaps = 28/240 (11%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA---- 60
F + VIITG+ G+GR A+ +AK G +V + ++ +++ K+ D+
Sbjct: 4 FAGKSVIITGSSSGIGRATAVLFAKNGAQVTITGRNAEKLEATKKKLLKVVKTPDSVNVV 63
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAG--ILRDSSFAKMSEKQFQQVIDVHLNG 118
VAN I+++A+ FG++DILINNAG ++ + S + + ++
Sbjct: 64 VANLTDAQGQD-QIIQSAVKKFGKIDILINNAGANVVDGTVNTDQSIDLYHKTFQINFQA 122
Query: 119 AFKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
++ + ++ + K G I+N S AG Y+AAK L + +A + K
Sbjct: 123 VVEMVKKTKKYLIESK-GEIVNVSSIAAGPQAVSMSPYYAAAKAALNQYTRCVALDLIKQ 181
Query: 178 NINVNSIAP--LARSAMTENVIPANILKEL-----------------GPEKIAPLILYLT 218
+ VNS++P +A + M +P K++ PE IA LI++L+
Sbjct: 182 GVRVNSVSPGIIATNFMGAMGVPEQAQKKIVNLFASEKGCIPAGVPGKPEDIAELIVFLS 241
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 79.7 bits (195), Expect = 2e-14
Identities = 55/190 (28%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANY 64
F +V ++TG+ G+GR A+ A+ G KV + + QEI K G D V +
Sbjct: 4 FSGKVALVTGSSNGIGRATAVLLAQEGAKVTITGRNADRLEETRQEILKSGVPEDHVLSI 63
Query: 65 --DSVSDNGA-AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ----FQQVIDVHLN 117
D ++ G +V + I FGR+DIL+NNAG + ++ Q + +++ +++
Sbjct: 64 ATDLATEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDRIMQINMR 123
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLAKEGYK 176
LT+ A H+ K K G ++N S AG Y+ +K L + S A + +
Sbjct: 124 SVVTLTQKAKEHLVKAK-GEVVNVSSIGAGPQAQPTFMYYAMSKAALDQYTRSAAIDLIQ 182
Query: 177 YNINVNSIAP 186
Y + VNS++P
Sbjct: 183 YGVRVNSVSP 192
Score = 72.0 bits (175), Expect = 4e-12
Identities = 54/191 (28%), Positives = 101/191 (52%), Gaps = 13/191 (6%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSG------SAVA 366
GKV ++TGS +G+G++ A A+ GAKV I R+ + + + SG ++A
Sbjct: 6 GKVALVTGSSNGIGRATAVLLAQEGAKVTITG-RNADRLEETRQEILKSGVPEDHVLSIA 64
Query: 367 DTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDE----WNAVINVHLFS 422
K ++V + + KFGR+DILVNNAG + ++ D+ ++ ++ +++ S
Sbjct: 65 TDLATEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDRIMQINMRS 124
Query: 423 TFALSKAVWPIFLKQKSGYIINTTST-SGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
L++ +K K G ++N +S +G YA +KAA+ ++R+ A++ +
Sbjct: 125 VVTLTQKAKEHLVKAK-GEVVNVSSIGAGPQAQPTFMYYAMSKAALDQYTRSAAIDLIQY 183
Query: 482 GITVNVIAPHA 492
G+ VN ++P A
Sbjct: 184 GVRVNSVSPGA 194
>CE09969 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 79.7 bits (195), Expect = 2e-14
Identities = 49/181 (27%), Positives = 86/181 (47%), Gaps = 1/181 (0%)
Query: 7 DRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDS 66
DRV ++T + G+G A + G VVV + D V ++ + +
Sbjct: 11 DRVALVTASTKGIGFAIAKQLGAAGASVVVCSRKKENVDEAVAALRLENIDAHGTTAHVG 70
Query: 67 VSDNGAAIVETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVHLNGAFKLTRA 125
+ +++ + F ++DIL++NA + K+++ Q+ +++D+++ AF+LT+
Sbjct: 71 NKSDRTKLIDFTLDRFTKLDILVSNAAVNPHYGDLMKVTDSQWDKLLDLNVKSAFELTKE 130
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIA 185
A PH+ G ++ S AG YS K L G +SLA + NI VNSIA
Sbjct: 131 AVPHLEASGRGNVVFVSSVAGYSPMNEIGAYSVMKTTLTGLSKSLALNLARRNIRVNSIA 190
Query: 186 P 186
P
Sbjct: 191 P 191
Score = 73.2 bits (178), Expect = 2e-12
Identities = 63/237 (26%), Positives = 112/237 (46%), Gaps = 24/237 (10%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVI------NDIRDPSAVVDEINKKYGSG 362
K L +V ++T S G+G + A+ GA VV+ N +A+ E +G+
Sbjct: 7 KFLTDRVALVTASTKGIGFAIAKQLGAAGASVVVCSRKKENVDEAVAALRLENIDAHGTT 66
Query: 363 SAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRS-FAKMTEDEWNAVINVHLF 421
+ V + D K ++ +D+F ++DILV+NA + K+T+ +W+ ++++++
Sbjct: 67 AHVGNKSDRTK----LIDFTLDRFTKLDILVSNAAVNPHYGDLMKVTDSQWDKLLDLNVK 122
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCN-YAAAKAAILGFSRTLALEGTK 480
S F L+K P G ++ +S +G Y + Y+ K + G S++LAL +
Sbjct: 123 SAFELTKEAVPHLEASGRGNVVFVSSVAG-YSPMNEIGAYSVMKTTLTGLSKSLALNLAR 181
Query: 481 RGITVNVIAPH-AETAMTKTIFSSKELNNHF----------DPGFVSPFVVLLCSDE 526
R I VN IAP +T ++ +FS + + DP + V L SDE
Sbjct: 182 RNIRVNSIAPGIIQTDFSQVLFSDESEKQKWLSQIAQRRFGDPDECAEAVAFLVSDE 238
>At3g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 259
Score = 79.7 bits (195), Expect = 2e-14
Identities = 60/185 (32%), Positives = 94/185 (50%), Gaps = 6/185 (3%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
L GK+VIITG SG+G A+ F +GAKVVI D+++ + + G A D
Sbjct: 6 LDGKIVIITGGASGIGAEAARLFTDHGAKVVIVDLQE--ELGQNVAVSIGLDKASFYRCD 63
Query: 371 IV--KEAQQVVQTAVDKFGRVDILVNNAGILRDR-SFAKMTEDEWNAVINVHLFSTFALS 427
I E + V+ V+K G++D+L +NAG++ S + + ++ + V++ A
Sbjct: 64 ITDETEVENAVKFTVEKHGKLDVLFSNAGVMEPHGSILDLDLEAFDRTMAVNVRGAAAFI 123
Query: 428 K-AVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
K A + G I+ TTS + G G +Y A+K A+LG R+ K GI VN
Sbjct: 124 KHAARSMVASGTRGSIVCTTSVTAEIGGPGPHSYTASKHALLGLVRSACGGLGKYGIRVN 183
Query: 487 VIAPH 491
+AP+
Sbjct: 184 GVAPY 188
Score = 65.9 bits (159), Expect = 3e-10
Identities = 53/183 (28%), Positives = 82/183 (43%), Gaps = 8/183 (4%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
++VIITG G+G A + G KVV+ DL +V I G A +
Sbjct: 9 KIVIITGGASGIGAEAARLFTDHGAKVVIVDLQEELGQNVAVSI----GLDKASFYRCDI 64
Query: 68 SDNGAA--IVETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVHLNGAFKLTR 124
+D V+ + G++D+L +NAG++ S + + F + + V++ GA +
Sbjct: 65 TDETEVENAVKFTVEKHGKLDVLFSNAGVMEPHGSILDLDLEAFDRTMAVNVRGAAAFIK 124
Query: 125 -AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNS 183
AA + G I+ T S G G +Y+A+K LLG S KY I VN
Sbjct: 125 HAARSMVASGTRGSIVCTTSVTAEIGGPGPHSYTASKHALLGLVRSACGGLGKYGIRVNG 184
Query: 184 IAP 186
+AP
Sbjct: 185 VAP 187
>At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 327
Score = 79.7 bits (195), Expect = 2e-14
Identities = 61/189 (32%), Positives = 88/189 (46%), Gaps = 6/189 (3%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA 60
+ + K R ITG G+G A A G +V + S + + I+ G A
Sbjct: 33 IKIPIKSRHAFITGGSSGIGLALAHRAASEGARVSILARSGSKLEEAKKSIQLATGVEVA 92
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
+ D V D A V AI G +D+LI N G+ K S + + IDV+L G+F
Sbjct: 93 TFSAD-VRDYDA--VSKAIDESGPIDVLIVNQGVFTAKELVKHSPEDVKFTIDVNLVGSF 149
Query: 121 KLTRAAWPHMRKQKF---GRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
+ +AA P M+ +K I S AG G +G A YSA+K GL G ++L +E
Sbjct: 150 NVIKAALPAMKARKDRGPASISLVSSQAGQVGVYGYAAYSASKFGLQGLAQALQQEVISD 209
Query: 178 NINVNSIAP 186
+I+V I P
Sbjct: 210 DIHVTLIFP 218
Score = 65.9 bits (159), Expect = 3e-10
Identities = 54/192 (28%), Positives = 92/192 (47%), Gaps = 9/192 (4%)
Query: 305 PIPIK-SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINK--KYGS 361
P PIK ++ + ITG SG+G + A A GA+V I + + ++E K + +
Sbjct: 30 PRPIKIPIKSRHAFITGGSSGIGLALAHRAASEGARVSI--LARSGSKLEEAKKSIQLAT 87
Query: 362 GSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
G VA V++ V A+D+ G +D+L+ N G+ + K + ++ I+V+L
Sbjct: 88 GVEVATFSADVRD-YDAVSKAIDESGPIDVLIVNQGVFTAKELVKHSPEDVKFTIDVNLV 146
Query: 422 STFALSKAVWPIFLKQKS---GYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEG 478
+F + KA P +K I +S +G G +G Y+A+K + G ++ L E
Sbjct: 147 GSFNVIKAALPAMKARKDRGPASISLVSSQAGQVGVYGYAAYSASKFGLQGLAQALQQEV 206
Query: 479 TKRGITVNVIAP 490
I V +I P
Sbjct: 207 ISDDIHVTLIFP 218
>At2g30670 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 79.7 bits (195), Expect = 2e-14
Identities = 63/229 (27%), Positives = 109/229 (47%), Gaps = 16/229 (6%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP--SAVVDEINKK-YGSGSAVA 366
SL+G ++TG SG+G + + A GA++ + DI + + + E KK + ++
Sbjct: 6 SLQGMTALVTGGASGIGHAIVEELAGLGARIYVCDISETLLNQSLSEWEKKGFQVSGSIC 65
Query: 367 DTHDIVKEAQQVVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
D E + ++QT F G+++ILVNN G++ + + +++ I+ +L S +
Sbjct: 66 DVSSH-SERETLMQTVSKMFDGKLNILVNNVGVVNPKPTIEYVAADFSFSISTNLESAYH 124
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
LS+ P+ + G II +S G+ Y+ K A+ ++TLA E + GI
Sbjct: 125 LSQLSHPLLKASEFGSIIFISSVGGVVSMECGSIYSLTKGALNQLAKTLACEWARDGIRA 184
Query: 486 NVIAPH-AETAMT----------KTIFSSKELNNHFDPGFVSPFVVLLC 523
N +AP+ TAM K++ S L +P VS V LC
Sbjct: 185 NSVAPNFIYTAMAQPFFKDADYEKSLVSRTPLGRAGEPNEVSSLVAFLC 233
Score = 66.6 bits (161), Expect = 2e-10
Identities = 46/178 (25%), Positives = 85/178 (46%), Gaps = 3/178 (1%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGE-GDAVANYDSVSD 69
++TG G+G E A G ++ V D+ + + + E +K G + ++ + S S+
Sbjct: 13 LVTGGASGIGHAIVEELAGLGARIYVCDISETLLNQSLSEWEKKGFQVSGSICDVSSHSE 72
Query: 70 NGAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWP 128
+++T F G+++IL+NN G++ + F I +L A+ L++ + P
Sbjct: 73 R-ETLMQTVSKMFDGKLNILVNNVGVVNPKPTIEYVAADFSFSISTNLESAYHLSQLSHP 131
Query: 129 HMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
++ +FG II S G+ + YS K L ++LA E + I NS+AP
Sbjct: 132 LLKASEFGSIIFISSVGGVVSMECGSIYSLTKGALNQLAKTLACEWARDGIRANSVAP 189
>CE05726 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 79.3 bits (194), Expect = 2e-14
Identities = 64/242 (26%), Positives = 109/242 (44%), Gaps = 26/242 (10%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGD---AV 61
F + VIITG+ G+GR A+ +AK G +V + + Q+I K G + AV
Sbjct: 4 FSGKSVIITGSSNGIGRSAAVIFAKEGAQVTITGRNEDRLEETKQQILKAGVPAEKINAV 63
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSE--KQFQQVIDVHLNGA 119
+ + I+ T ++ FG++DIL+NNAG A + + +Q+ ++
Sbjct: 64 VADVTEASGQDDIINTTLAKFGKIDILVNNAGANLADGTANTDQPVELYQKTFKLNFQAV 123
Query: 120 FKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYN 178
++T+ H+ K K G I+N S AG + G Y+ AK L + A + ++
Sbjct: 124 IEMTQKTKEHLIKTK-GEIVNVSSIVAGPQAHSGYPYYACAKAALDQYTRCTAIDLIQHG 182
Query: 179 INVNSIAP--LARSAMTENVIPANILKEL-----------------GPEKIAPLILYLTH 219
+ VNS++P +A M +P +L PE+IA +I++L
Sbjct: 183 VRVNSVSPGAVATGFMGAMGLPETASDKLYSFIGSRKECIPVGHCGKPEEIANIIVFLAD 242
Query: 220 EN 221
N
Sbjct: 243 RN 244
Score = 75.9 bits (185), Expect = 3e-13
Identities = 63/195 (32%), Positives = 101/195 (51%), Gaps = 23/195 (11%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIV 372
GK VIITGS +G+G+S A FA+ GA+V I R+ + + + +G + +V
Sbjct: 6 GKSVIITGSSNGIGRSAAVIFAKEGAQVTITG-RNEDRLEETKQQILKAGVPAEKINAVV 64
Query: 373 KEAQQ------VVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF-STFA 425
+ + ++ T + KFG++DILVNNAG A + + N V L+ TF
Sbjct: 65 ADVTEASGQDDIINTTLAKFGKIDILVNNAG-------ANLADGTANTDQPVELYQKTFK 117
Query: 426 LS-KAVWPIFLKQK------SGYIINTTS-TSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
L+ +AV + K K G I+N +S +G + G YA AKAA+ ++R A++
Sbjct: 118 LNFQAVIEMTQKTKEHLIKTKGEIVNVSSIVAGPQAHSGYPYYACAKAALDQYTRCTAID 177
Query: 478 GTKRGITVNVIAPHA 492
+ G+ VN ++P A
Sbjct: 178 LIQHGVRVNSVSPGA 192
>At5g06060 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 79.3 bits (194), Expect = 2e-14
Identities = 64/252 (25%), Positives = 117/252 (46%), Gaps = 21/252 (8%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT- 368
SL GK ++TG G+G++ + A++GAKV R+ + +N +G V+ +
Sbjct: 8 SLAGKTALVTGGTRGIGRAVVEELAKFGAKVHTCS-RNQEELNACLNDWKANGLVVSGSV 66
Query: 369 --HDIVKEAQQVVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
+ + ++++Q A F G+++IL+NN G + + + +E+ +++ +L S F
Sbjct: 67 CDASVRDQREKLIQEASSAFSGKLNILINNVGTNVRKPTVEYSSEEYAKIMSTNLESAFH 126
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
LS+ P+ G I+ +S +G+ Y A K A+ +R LA E I
Sbjct: 127 LSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSIYGATKGALNQLTRNLACEWASDNIRT 186
Query: 486 NVIAP-HAETAMTKTIFSSKE----------LNNHFDPGFVSPFVVLLCSDELQELGKNR 534
N +AP + +T++ +T+ KE L +P VS V LC +
Sbjct: 187 NCVAPWYIKTSLVETLLEKKEFVEAVVSRTPLGRVGEPEEVSSLVAFLCLP-----ASSY 241
Query: 535 VKGLLFEVGGGW 546
+ G + V GG+
Sbjct: 242 ITGQVISVDGGF 253
Score = 76.3 bits (186), Expect = 2e-13
Identities = 63/242 (26%), Positives = 107/242 (44%), Gaps = 14/242 (5%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+ ++TG G+GR E AK G KV + ++ + + K G SV
Sbjct: 12 KTALVTGGTRGIGRAVVEELAKFGAKVHTCSRNQEELNACLNDWKANGLVVSGSVCDASV 71
Query: 68 SDNGAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAA 126
D +++ A S F G+++ILINN G + S +++ +++ +L AF L++ A
Sbjct: 72 RDQREKLIQEASSAFSGKLNILINNVGTNVRKPTVEYSSEEYAKIMSTNLESAFHLSQIA 131
Query: 127 WPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
P ++ G I+ S AGL + Y A K L +LA E NI N +AP
Sbjct: 132 HPLLKASGVGSIVFISSVAGLVHLSSGSIYGATKGALNQLTRNLACEWASDNIRTNCVAP 191
Query: 187 -----------LARSAMTENVIPANILKELG-PEKIAPLILYL-THENTKVTNNIFELAA 233
L + E V+ L +G PE+++ L+ +L ++ +T + +
Sbjct: 192 WYIKTSLVETLLEKKEFVEAVVSRTPLGRVGEPEEVSSLVAFLCLPASSYITGQVISVDG 251
Query: 234 GF 235
GF
Sbjct: 252 GF 253
>7295487 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 317
Score = 79.3 bits (194), Expect = 2e-14
Identities = 60/215 (27%), Positives = 112/215 (51%), Gaps = 26/215 (12%)
Query: 308 IKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPS--AVVDEINK----KYGS 361
+K L GKV ++T S G+G + A+ A GA VVI+ + + + + E+ K +G
Sbjct: 66 MKRLAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGL 125
Query: 362 GSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNA-------GILRDRSFAKMTEDEWNA 414
V++ D +Q+ + + KFG+++ILV+NA G+L + E W+
Sbjct: 126 KCHVSEPED----RKQLFEETISKFGKLNILVSNAATNPAVGGVL------ECDEKVWDK 175
Query: 415 VINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCN-YAAAKAAILGFSRT 473
+ +V++ S++ L+K P+ +QK+ I+ +S +G Y F Y+ +K A++G ++
Sbjct: 176 IFDVNVKSSYLLAKEALPLLRQQKNSSIVFVSSIAG-YDAFELLGAYSVSKTALIGLTKA 234
Query: 474 LALEGTKRGITVNVIAPHA-ETAMTKTIFSSKELN 507
A + GI VN +AP T +K ++ ++ N
Sbjct: 235 AAKDLAPEGIRVNCLAPGVIRTKFSKALYENESAN 269
Score = 77.4 bits (189), Expect = 9e-14
Identities = 50/180 (27%), Positives = 90/180 (49%), Gaps = 1/180 (0%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+V ++T + G+G A A+ G VV++ + DS + E++KL + + S
Sbjct: 72 KVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHVSE 131
Query: 68 SDNGAAIVETAISNFGRVDILINNAGI-LRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAA 126
++ + E IS FG+++IL++NA + EK + ++ DV++ ++ L + A
Sbjct: 132 PEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKSSYLLAKEA 191
Query: 127 WPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
P +R+QK I+ S AG YS +K L+G ++ AK+ I VN +AP
Sbjct: 192 LPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCLAP 251
>Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 341
Score = 79.0 bits (193), Expect = 3e-14
Identities = 50/191 (26%), Positives = 89/191 (46%), Gaps = 25/191 (13%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+V +ITGAG GLGR++ALE+A+R +V+ D+ + + ++ + + +A
Sbjct: 37 QVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQ 96
Query: 68 SDNGAAIV-------------------------ETAISNFGRVDILINNAGILRDSSFAK 102
+ NG + E G V +L+NNAG++ +
Sbjct: 97 AGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLE 156
Query: 103 MSEKQFQQVIDVHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLG 162
++ ++ + V+ + F T+A P M + G I+ S GL+ G +Y A+K G
Sbjct: 157 CPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFG 216
Query: 163 LLGFGESLAKE 173
++GF ESL+ E
Sbjct: 217 VVGFHESLSHE 227
Score = 75.9 bits (185), Expect = 3e-13
Identities = 66/236 (27%), Positives = 107/236 (44%), Gaps = 33/236 (13%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPS-----AVVDEINKKYGSGS 363
KS+ G+V +ITG+GSGLG+ A FAR A +V+ DI S +V I + +
Sbjct: 32 KSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAAD 91
Query: 364 AVA--------------------DTHDIVKEAQQVVQTAV---DKFGRVDILVNNAGILR 400
A A T D+ K + V TA + G V +LVNNAG++
Sbjct: 92 AAALQAGNGEEEILPHCNLQVFTYTCDVGKR-ENVYLTAERVRKEVGEVSVLVNNAGVVS 150
Query: 401 DRSFAKMTEDEWNAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNY 460
+ ++ + V+ + F +KA P L+ G+I+ S+ G++ G +Y
Sbjct: 151 GHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDY 210
Query: 461 AAAKAAILGFSRTLALE---GTKRGITVNVIAPH-AETAMTKTIFSSKELNNHFDP 512
A+K ++GF +L+ E K GI ++ P+ +T M + KE+ P
Sbjct: 211 CASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPP 266
>CE27259 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 501
Score = 79.0 bits (193), Expect = 3e-14
Identities = 58/205 (28%), Positives = 104/205 (50%), Gaps = 21/205 (10%)
Query: 315 VVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIVKE 374
V I+TG+ SG+G++ A AR K+ + R+ +A+ + + +GS D +D++
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTG-RNVAALNELAGQIVSAGS---DKNDVLVT 58
Query: 375 AQQ---------VVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
A + +V V KFGR+D L+N+AGILR + ++ ++NV++ S
Sbjct: 59 AVELASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYDELMNVNVRSLIR 118
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
L++A P + K G ++N +S +G Y +K+A+ F++ LALE G+ V
Sbjct: 119 LTRAALPHIITTK-GTVVNVSSINGPCPFPNVTYYCMSKSAVDQFTKCLALEMAPNGVRV 177
Query: 486 NVIAP-------HAETAMTKTIFSS 503
N + P H + +T +S+
Sbjct: 178 NAVCPGVTVTNLHRTSGQDETTYSA 202
Score = 76.6 bits (187), Expect = 2e-13
Identities = 53/181 (29%), Positives = 88/181 (48%), Gaps = 4/181 (2%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGE-GDAVANYDSV 67
V I+TGA G+GR AL A+ K+ + +A + + +I G + D + +
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVEL 62
Query: 68 SDNGA--AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRA 125
+ A IV+ + FGR+D LIN+AGILR + + ++++V++ +LTRA
Sbjct: 63 ASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYDELMNVNVRSLIRLTRA 122
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIA 185
A PH+ K G ++N S G Y +K + F + LA E + VN++
Sbjct: 123 ALPHIITTK-GTVVNVSSINGPCPFPNVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVC 181
Query: 186 P 186
P
Sbjct: 182 P 182
>At2g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 322
Score = 79.0 bits (193), Expect = 3e-14
Identities = 60/229 (26%), Positives = 108/229 (46%), Gaps = 16/229 (6%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKV---VINDIRDPSAVVDEINKKYGSGSAVA 366
SL G ++TG G+G++ + A GA+V N+ + + D + +V
Sbjct: 67 SLNGMSALVTGGTRGIGRAIVEELAGLGAEVHTCARNEYELENCLSDWNRSGFRVAGSVC 126
Query: 367 DTHDIVKEAQQVVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
D D + + +++T F G++ ILVNN G + + T E++ +++ + S F
Sbjct: 127 DVSDR-SQREALMETVSSVFEGKLHILVNNVGTNIRKPMVEFTAGEFSTLMSTNFESVFH 185
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
L + +P+ + K+G ++ +S SG ++ K AI +R+LA E K I +
Sbjct: 186 LCQLAYPLLRESKAGSVVFISSVSGFVSLKNMSVQSSTKGAINQLTRSLACEWAKDNIRI 245
Query: 486 NVIAP-HAETAMTKTIFSSKE----------LNNHFDPGFVSPFVVLLC 523
N +AP + +T+M + + S+KE L +P VS V LC
Sbjct: 246 NAVAPWYIKTSMVEQVLSNKEYLEEVYSVTPLGRLGEPREVSSAVAFLC 294
Score = 62.4 bits (150), Expect = 3e-09
Identities = 49/191 (25%), Positives = 87/191 (44%), Gaps = 6/191 (3%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TG G+GR E A G +V ++ + + + G + VSD
Sbjct: 74 LVTGGTRGIGRAIVEELAGLGAEVHTCARNEYELENCLSDWNRSGFR--VAGSVCDVSDR 131
Query: 71 GA--AIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAW 127
A++ET S F G++ IL+NN G + + +F ++ + F L + A+
Sbjct: 132 SQREALMETVSSVFEGKLHILVNNVGTNIRKPMVEFTAGEFSTLMSTNFESVFHLCQLAY 191
Query: 128 PHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP- 186
P +R+ K G ++ S +G + S+ K + SLA E K NI +N++AP
Sbjct: 192 PLLRESKAGSVVFISSVSGFVSLKNMSVQSSTKGAINQLTRSLACEWAKDNIRINAVAPW 251
Query: 187 LARSAMTENVI 197
+++M E V+
Sbjct: 252 YIKTSMVEQVL 262
>Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 300
Score = 78.6 bits (192), Expect = 4e-14
Identities = 48/165 (29%), Positives = 81/165 (49%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVS 68
+V+ITGAG G+GR+ A E+AK K+V+ D+ + + + K LG + S
Sbjct: 38 IVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNR 97
Query: 69 DNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWP 128
++ + + + G V IL+NNAG++ S + Q ++ +V++ F T+A P
Sbjct: 98 EDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLP 157
Query: 129 HMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
M K G I+ S AG Y ++K +GF ++L E
Sbjct: 158 AMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDE 202
Score = 71.6 bits (174), Expect = 5e-12
Identities = 52/176 (29%), Positives = 87/176 (48%), Gaps = 12/176 (6%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAV--- 365
KS+ G++V+ITG+G G+G+ A FA+ +K+V+ DI + + + K G G+ V
Sbjct: 32 KSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDI-NKHGLEETAAKCKGLGAKVHTF 90
Query: 366 ----ADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
++ DI A++V + G V ILVNNAG++ + + V++
Sbjct: 91 VVDCSNREDIYSSAKKVKA----EIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVL 146
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
+ F +KA P K G+I+ S +G Y ++K A +GF +TL E
Sbjct: 147 AHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDE 202
>Hs7657478 [Q] KOG1205 Predicted dehydrogenase
Length = 311
Score = 78.6 bits (192), Expect = 4e-14
Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 9/184 (4%)
Query: 8 RVVIITGAGGGLGRVYALEYA---KRGGKVV--VNDLGRSAADSVVQEIKKLGGEGDAVA 62
R V+I+G G+G A++ A K+ +VV + DLG+ +++ + G+ VA
Sbjct: 6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKK--ETLEAAAGEALGQTLTVA 63
Query: 63 NYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKL 122
D SD A + I G VD+L+NNAG+ +S Q V D + GA +L
Sbjct: 64 QLDVCSDESVAQCLSCIQ--GEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRL 121
Query: 123 TRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVN 182
+A P M++++ G I+ S GL G Y+A+K L GF ESLA + ++NI ++
Sbjct: 122 VKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFIS 181
Query: 183 SIAP 186
+ P
Sbjct: 182 LVEP 185
Score = 61.6 bits (148), Expect = 5e-09
Identities = 53/187 (28%), Positives = 85/187 (45%), Gaps = 17/187 (9%)
Query: 314 KVVIITGSGSGLGKSHAQWFA-----RYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
+ V+I+G SG+G A A RY + D+ + + G VA
Sbjct: 6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQL 65
Query: 369 HDIVKEAQQVVQTAVDKFGRVDILVNNAGI-----LRDRSFAKMTEDEWNAVINVHLFST 423
D+ + + V Q G VD+LVNNAG+ L S A M V + + F
Sbjct: 66 -DVCSD-ESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQN-----VFDTNFFGA 118
Query: 424 FALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
L KAV P +++ G+I+ +S G+ G YAA+K A+ GF +LA++ + I
Sbjct: 119 VRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNI 178
Query: 484 TVNVIAP 490
++++ P
Sbjct: 179 FISLVEP 185
>CE21095 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 78.6 bits (192), Expect = 4e-14
Identities = 53/190 (27%), Positives = 90/190 (46%), Gaps = 9/190 (4%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLG---GEGDAV 61
F ++ VIITG+ G+GR A+ +A+ G V + + Q I K G + ++V
Sbjct: 4 FSNKTVIITGSSNGIGRTTAILFAQEGANVTITGRSSERLEETRQIILKSGVSEKQVNSV 63
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ----FQQVIDVHLN 117
+ D I+ + + FG++D+L+NNAG +F Q + + + ++L
Sbjct: 64 VADVTTEDGQDQIINSTLKQFGKIDVLVNNAGAAIPDAFGTTGTDQGIDIYHKTLKLNLQ 123
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLAKEGYK 176
++T+ PH+ K G I+N S AG Y+ AK L + S A + K
Sbjct: 124 AVIEMTKKVKPHLVASK-GEIVNVSSIVAGPQAQPDFLYYAIAKAALDQYTRSTAIDLAK 182
Query: 177 YNINVNSIAP 186
+ I VNS++P
Sbjct: 183 FGIRVNSVSP 192
Score = 77.4 bits (189), Expect = 9e-14
Identities = 60/209 (28%), Positives = 104/209 (49%), Gaps = 14/209 (6%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIVK 373
K VIITGS +G+G++ A FA+ GA V I R + + SG + + +V
Sbjct: 7 KTVIITGSSNGIGRTTAILFAQEGANVTITG-RSSERLEETRQIILKSGVSEKQVNSVVA 65
Query: 374 EA------QQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDE----WNAVINVHLFST 423
+ Q++ + + +FG++D+LVNNAG +F D+ ++ + ++L +
Sbjct: 66 DVTTEDGQDQIINSTLKQFGKIDVLVNNAGAAIPDAFGTTGTDQGIDIYHKTLKLNLQAV 125
Query: 424 FALSKAVWPIFLKQKSGYIINTTS-TSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
++K V P + K G I+N +S +G YA AKAA+ ++R+ A++ K G
Sbjct: 126 IEMTKKVKPHLVASK-GEIVNVSSIVAGPQAQPDFLYYAIAKAALDQYTRSTAIDLAKFG 184
Query: 483 ITVNVIAP-HAETAMTKTIFSSKELNNHF 510
I VN ++P ET T + + + F
Sbjct: 185 IRVNSVSPGMVETGFTNAMGMPDQASQKF 213
>At2g29310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 78.6 bits (192), Expect = 4e-14
Identities = 64/232 (27%), Positives = 108/232 (45%), Gaps = 22/232 (9%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP--SAVVDEINKK----YGSGS 363
SL+G ++TG+ SG+G + + A +GA + I DI + S + E KK GS
Sbjct: 6 SLQGMTALVTGAASGIGYAIVEELASFGAIIHICDISETLLSQSLSEWEKKGFQVSGSIC 65
Query: 364 AVADTHDIVKEAQQVVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFS 422
VA D ++++QT F G+++ILVNN G++R + + ++++ I+ +L
Sbjct: 66 DVASRPD----REKLMQTVSSLFDGKLNILVNNVGVIRGKPTTEYVAEDFSYHISTNLEP 121
Query: 423 TFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
F S+ + G I+ +S +G+ Y+ K A+ +R LA E K G
Sbjct: 122 AFHFSQLSHLLLKASGFGSIVFMSSATGVVSVQCGSIYSLTKGALNQLTRNLACEWAKDG 181
Query: 483 ITVNVIAPHA-----------ETAMTKTIFSSKELNNHFDPGFVSPFVVLLC 523
I N +AP+ + + +FS L +P V+ VV LC
Sbjct: 182 IRANAVAPNVVKTPLSQSYLEDVGFKEALFSRTPLGRAGEPNEVASLVVFLC 233
Score = 61.6 bits (148), Expect = 5e-09
Identities = 54/221 (24%), Positives = 103/221 (46%), Gaps = 15/221 (6%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGE-GDAVANYDSVSD 69
++TGA G+G E A G + + D+ + + E +K G + ++ + S D
Sbjct: 13 LVTGAASGIGYAIVEELASFGAIIHICDISETLLSQSLSEWEKKGFQVSGSICDVASRPD 72
Query: 70 NGAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWP 128
+++T S F G+++IL+NN G++R + + F I +L AF ++ +
Sbjct: 73 R-EKLMQTVSSLFDGKLNILVNNVGVIRGKPTTEYVAEDFSYHISTNLEPAFHFSQLSHL 131
Query: 129 HMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP-L 187
++ FG I+ S G+ + YS K L +LA E K I N++AP +
Sbjct: 132 LLKASGFGSIVFMSSATGVVSVQCGSIYSLTKGALNQLTRNLACEWAKDGIRANAVAPNV 191
Query: 188 ARSAMTENVIPANILKE-------LG----PEKIAPLILYL 217
++ ++++ + KE LG P ++A L+++L
Sbjct: 192 VKTPLSQSYLEDVGFKEALFSRTPLGRAGEPNEVASLVVFL 232
>7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 321
Score = 78.6 bits (192), Expect = 4e-14
Identities = 55/186 (29%), Positives = 91/186 (48%), Gaps = 12/186 (6%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIK-----KLGGEGDAVAN 63
V ++TGAG GLGR +LE AK+G + V D+ S A+ V++I+ + V N
Sbjct: 54 VAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDIYKVRAKAYKANVTN 113
Query: 64 YDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLT 123
YD + + + +VE G V +L+NNAG++ + Q +I+V+L F
Sbjct: 114 YDDLVELNSKVVE----EMGPVTVLVNNAGVMMHRNMFNPDPADVQLMINVNLTSHFWTK 169
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE---GYKYNIN 180
P M++ + G I+ S AG++ A Y+ K G L +L E + +I+
Sbjct: 170 LVFLPKMKELRKGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELDLENQKDIH 229
Query: 181 VNSIAP 186
V ++ P
Sbjct: 230 VTTVLP 235
Score = 72.8 bits (177), Expect = 2e-12
Identities = 53/192 (27%), Positives = 92/192 (47%), Gaps = 14/192 (7%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSA--VVDEINKKY-----GS 361
KS+ G+V ++TG+G GLG++ + A+ G + + DI A V +I Y
Sbjct: 48 KSIAGEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDIYKVRAKAY 107
Query: 362 GSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
+ V + D+V+ +VV+ + G V +LVNNAG++ R+ + +INV+L
Sbjct: 108 KANVTNYDDLVELNSKVVE----EMGPVTVLVNNAGVMMHRNMFNPDPADVQLMINVNLT 163
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE---G 478
S F P + + G+I+ +S +G++ Y K+ L RTL +E
Sbjct: 164 SHFWTKLVFLPKMKELRKGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELDLE 223
Query: 479 TKRGITVNVIAP 490
++ I V + P
Sbjct: 224 NQKDIHVTTVLP 235
>At3g47360 [Q] KOG1205 Predicted dehydrogenase
Length = 309
Score = 78.2 bits (191), Expect = 5e-14
Identities = 54/181 (29%), Positives = 100/181 (54%), Gaps = 6/181 (3%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKV-VINDIRDPSAVVDEINKKYGSGSAVADTHDI- 371
KVV+ITG+ SG+G+ A +A+ GA + ++ RD +V E +++ GSG+ + D+
Sbjct: 48 KVVLITGASSGIGEHVAYEYAKKGAYLALVARRRDRLEIVAETSRQLGSGNVIIIPGDVS 107
Query: 372 -VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTE-DEWNAVINVHLFSTFALSKA 429
V++ ++ + + FG++D L+NNAG+ + F T+ + N +++++ + T ++
Sbjct: 108 NVEDCKKFIDETIRHFGKLDHLINNAGVFQTVLFEDFTQIQDANPIMDINFWGTTYITYF 167
Query: 430 VWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVIA 489
P L++ G I+ TS S YAA+KAA+L F TL +E I + ++
Sbjct: 168 AIP-HLRKSKGKIVAITSGSANIPLPLASIYAASKAALLRFFETLRIE-LSPDIKITIVL 225
Query: 490 P 490
P
Sbjct: 226 P 226
Score = 74.7 bits (182), Expect = 6e-13
Identities = 54/169 (31%), Positives = 90/169 (52%), Gaps = 5/169 (2%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+VV+ITGA G+G A EYAK+G + + R + V + ++L G G+ + V
Sbjct: 48 KVVLITGASSGIGEHVAYEYAKKGAYLALVARRRDRLEIVAETSRQL-GSGNVIIIPGDV 106
Query: 68 S--DNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ-FQQVIDVHLNGAFKLTR 124
S ++ ++ I +FG++D LINNAG+ + F ++ Q ++D++ G +T
Sbjct: 107 SNVEDCKKFIDETIRHFGKLDHLINNAGVFQTVLFEDFTQIQDANPIMDINFWGTTYITY 166
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
A PH+RK K G+I+ S + + Y+A+K LL F E+L E
Sbjct: 167 FAIPHLRKSK-GKIVAITSGSANIPLPLASIYAASKAALLRFFETLRIE 214
>At3g29250 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 77.8 bits (190), Expect = 7e-14
Identities = 64/197 (32%), Positives = 98/197 (49%), Gaps = 17/197 (8%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP----SAVVDEINKKYGSGSAVA 366
L GK+ IITG SG+G + F +GAKVVI DI++ AV ++K V
Sbjct: 6 LDGKIAIITGGASGIGAEAVRLFTDHGAKVVIVDIQEELGQNLAVSIGLDKASFYRCNVT 65
Query: 367 DTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNA-----VINVHLF 421
D D+ + V+ V+K G++D+L +NAG+L +F + + + A +NV
Sbjct: 66 DETDV----ENAVKFTVEKHGKLDVLFSNAGVL--EAFGSVLDLDLEAFDRTMAVNVRGA 119
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
+ F + A + G I+ TTS + G G +Y A+K A+LG R+ +
Sbjct: 120 AAF-IKHAARSMVASGTRGSIVCTTSIAAEIGGPGPHSYTASKHALLGLIRSACAGLGQY 178
Query: 482 GITVNVIAPH-AETAMT 497
GI VN +AP+ T MT
Sbjct: 179 GIRVNGVAPYGVATGMT 195
Score = 61.6 bits (148), Expect = 5e-09
Identities = 52/188 (27%), Positives = 83/188 (43%), Gaps = 8/188 (4%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVA 62
L ++ IITG G+G + G KVV+ D+ ++ I G A
Sbjct: 4 LRLDGKIAIITGGASGIGAEAVRLFTDHGAKVVIVDIQEELGQNLAVSI----GLDKASF 59
Query: 63 NYDSVSDNGAA--IVETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVHLNGA 119
+V+D V+ + G++D+L +NAG+L S + + F + + V++ GA
Sbjct: 60 YRCNVTDETDVENAVKFTVEKHGKLDVLFSNAGVLEAFGSVLDLDLEAFDRTMAVNVRGA 119
Query: 120 FKLTR-AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYN 178
+ AA + G I+ T S A G G +Y+A+K LLG S +Y
Sbjct: 120 AAFIKHAARSMVASGTRGSIVCTTSIAAEIGGPGPHSYTASKHALLGLIRSACAGLGQYG 179
Query: 179 INVNSIAP 186
I VN +AP
Sbjct: 180 IRVNGVAP 187
>7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 361
Score = 77.8 bits (190), Expect = 7e-14
Identities = 52/172 (30%), Positives = 83/172 (48%), Gaps = 3/172 (1%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVD-EINKKYGSGSAVAD 367
K + GKV ++TG GSGLG+ AR G K+ + D+ E+ K A A
Sbjct: 88 KDVSGKVALVTGGGSGLGREICLELARRGCKLAVVDVNSKGCYETVELLSKIPRCVAKAY 147
Query: 368 THDIV--KEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
+D+ +E Q + + G VDILVNNA ++ S + DE + ++ ++L S
Sbjct: 148 KNDVSSPRELQLMAAKVEKELGPVDILVNNASLMPMTSTPSLKSDEIDTILQLNLGSYIM 207
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
+K P + +KSG+++ + +G+ G Y A K I GF +L E
Sbjct: 208 TTKEFLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAE 259
Score = 76.6 bits (187), Expect = 2e-13
Identities = 52/177 (29%), Positives = 83/177 (46%), Gaps = 4/177 (2%)
Query: 1 MSLEFKD---RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGE 57
+ L+ KD +V ++TG G GLGR LE A+RG K+ V D+ V+ + K+
Sbjct: 83 LGLKEKDVSGKVALVTGGGSGLGREICLELARRGCKLAVVDVNSKGCYETVELLSKIPRC 142
Query: 58 GDAVANYDSVSDNGAAIVETAISN-FGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHL 116
D S ++ + G VDIL+NNA ++ +S + + ++ ++L
Sbjct: 143 VAKAYKNDVSSPRELQLMAAKVEKELGPVDILVNNASLMPMTSTPSLKSDEIDTILQLNL 202
Query: 117 NGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
T+ P M +K G ++ + AGL G Y+A K G+ GF ESL E
Sbjct: 203 GSYIMTTKEFLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAE 259
>At2g47140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 77.4 bits (189), Expect = 9e-14
Identities = 57/184 (30%), Positives = 91/184 (48%), Gaps = 6/184 (3%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
L GK+VIITG SG+G + F +GA+VVI D++D + + G A D
Sbjct: 13 LDGKIVIITGGASGIGAESVRLFTEHGARVVIVDVQD--ELGQNVAVSIGEDKASYYHCD 70
Query: 371 IVK--EAQQVVQTAVDKFGRVDILVNNAGILRD-RSFAKMTEDEWNAVINVHLFSTFALS 427
+ E + V+ V+K+G++D+L +NAG++ S + +E + I ++L T A
Sbjct: 71 VTNETEVENAVKFTVEKYGKLDVLFSNAGVIEPFVSILDLNLNELDRTIAINLRGTAAFI 130
Query: 428 K-AVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
K A + K G I+ TTS + Y +K +LG ++ + K GI VN
Sbjct: 131 KHAARAMVEKGIRGSIVCTTSVAAEIAGTAPHGYTTSKHGLLGLIKSASGGLGKYGIRVN 190
Query: 487 VIAP 490
+AP
Sbjct: 191 GVAP 194
Score = 66.6 bits (161), Expect = 2e-10
Identities = 52/185 (28%), Positives = 85/185 (45%), Gaps = 12/185 (6%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
++VIITG G+G + + G +VV+ D+ +V I G+ A+Y
Sbjct: 16 KIVIITGGASGIGAESVRLFTEHGARVVIVDVQDELGQNVAVSI------GEDKASYYHC 69
Query: 68 SDNGAAIVETAIS----NFGRVDILINNAGILRDS-SFAKMSEKQFQQVIDVHLNG-AFK 121
VE A+ +G++D+L +NAG++ S ++ + + I ++L G A
Sbjct: 70 DVTNETEVENAVKFTVEKYGKLDVLFSNAGVIEPFVSILDLNLNELDRTIAINLRGTAAF 129
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINV 181
+ AA + K G I+ T S A Y+ +K GLLG +S + KY I V
Sbjct: 130 IKHAARAMVEKGIRGSIVCTTSVAAEIAGTAPHGYTTSKHGLLGLIKSASGGLGKYGIRV 189
Query: 182 NSIAP 186
N +AP
Sbjct: 190 NGVAP 194
>7301818 [Q] KOG1205 Predicted dehydrogenase
Length = 326
Score = 77.4 bits (189), Expect = 9e-14
Identities = 56/187 (29%), Positives = 93/187 (48%), Gaps = 8/187 (4%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSA-------VVDEINKKYGSGS 363
L GKVV+ITG+ SGLG+S A F R G +V++ R + +++ Y
Sbjct: 51 LPGKVVLITGASSGLGESLAHVFYRAGCRVILAARRTQELERVKKDLLALDVDPAYPPTV 110
Query: 364 AVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFST 423
D ++ + V + + +VDIL+NN GI A D V+ V+ F +
Sbjct: 111 LPLDLAEL-NSIPEFVTRVLAVYNQVDILINNGGISVRADVASTAVDVDLKVMVVNYFGS 169
Query: 424 FALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
AL+KA+ P +K+ SG+I +S G + + Y+A+K A+ F+ +L E + I
Sbjct: 170 VALTKALLPSMVKRGSGHICFISSVQGKFAIPQRAAYSASKHAMQAFADSLRAEVANKNI 229
Query: 484 TVNVIAP 490
V+ ++P
Sbjct: 230 NVSCVSP 236
Score = 71.2 bits (173), Expect = 6e-12
Identities = 63/223 (28%), Positives = 100/223 (44%), Gaps = 15/223 (6%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEG---DAVANY 64
+VV+ITGA GLG A + + G +V++ + V +++ L + V
Sbjct: 54 KVVLITGASSGLGESLAHVFYRAGCRVILAARRTQELERVKKDLLALDVDPAYPPTVLPL 113
Query: 65 DSVSDNGAA-IVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLT 123
D N V ++ + +VDILINN GI + A + +V+ V+ G+ LT
Sbjct: 114 DLAELNSIPEFVTRVLAVYNQVDILINNGGISVRADVASTAVDVDLKVMVVNYFGSVALT 173
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNS 183
+A P M K+ G I S G + +A YSA+K + F +SL E NINV+
Sbjct: 174 KALLPSMVKRGSGHICFISSVQGKFAIPQRAAYSASKHAMQAFADSLRAEVANKNINVSC 233
Query: 184 IAP-----------LARSAMTENVIPANILKELGPEKIAPLIL 215
++P L S + + K + P+K+A IL
Sbjct: 234 VSPGYIRTQLSLNALTGSGSSYGKVDETTAKGMSPDKLAERIL 276
>7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 336
Score = 77.4 bits (189), Expect = 9e-14
Identities = 51/184 (27%), Positives = 86/184 (46%), Gaps = 5/184 (2%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
R V++TG G+G A+E A +G V V V ++ + D Y S+
Sbjct: 36 RHVVVTGGSKGIGLCLAVECAMKGANVTVIARDEKMLSGAVALMEVIRQRPDQKFQYRSL 95
Query: 68 SDNG-----AAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKL 122
+G A ++ +FG + LIN AG+ F ++S + ++++V+ G +
Sbjct: 96 DISGDYDQVAKVLGEIEDSFGPIYTLINCAGMAICGVFEEVSVQDVHKLMNVNFFGTYNC 155
Query: 123 TRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVN 182
TR P M+K G I+ T S A ++G +G YSA K L E++A E ++ ++V
Sbjct: 156 TRYVLPKMKKAGDGIIVITASQAAMFGIYGYGPYSATKYALRAMAETIAMESREHGVSVT 215
Query: 183 SIAP 186
P
Sbjct: 216 LAMP 219
Score = 70.9 bits (172), Expect = 8e-12
Identities = 50/193 (25%), Positives = 93/193 (47%), Gaps = 15/193 (7%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVI-----NDIRDPSAVVDEINKK----- 358
+S+ G+ V++TG G+G A A GA V + + A+++ I ++
Sbjct: 31 RSIVGRHVVVTGGSKGIGLCLAVECAMKGANVTVIARDEKMLSGAVALMEVIRQRPDQKF 90
Query: 359 -YGSGSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVIN 417
Y S D + K V+ D FG + L+N AG+ F +++ + + ++N
Sbjct: 91 QYRSLDISGDYDQVAK----VLGEIEDSFGPIYTLINCAGMAICGVFEEVSVQDVHKLMN 146
Query: 418 VHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
V+ F T+ ++ V P K G I+ T S + ++G +G Y+A K A+ + T+A+E
Sbjct: 147 VNFFGTYNCTRYVLPKMKKAGDGIIVITASQAAMFGIYGYGPYSATKYALRAMAETIAME 206
Query: 478 GTKRGITVNVIAP 490
+ G++V + P
Sbjct: 207 SREHGVSVTLAMP 219
>7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 399
Score = 77.4 bits (189), Expect = 9e-14
Identities = 61/227 (26%), Positives = 99/227 (42%), Gaps = 8/227 (3%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVAN 63
E + +ITG G GLGR+ A K G KVV+ D+ + VQ +++ GG
Sbjct: 83 ELNTDIALITGGGNGLGRLLAERLGKMGTKVVIWDINKKGIAETVQIVEEAGGYCKGYVV 142
Query: 64 YDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLT 123
S + + G + +LINNAG++ + ++ +V++ F T
Sbjct: 143 DISKKEEVYKAADVIRDEVGDITLLINNAGVVSGLHLLDTPDHLIERSFNVNVMAHFWTT 202
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE----GYKYNI 179
+A P M + G I S AG G +Y A+K +GF E+L E G+ NI
Sbjct: 203 KAFLPKMIENDRGHIATIASLAGHVGISKLVDYCASKFAAVGFDEALRLELEVLGHT-NI 261
Query: 180 NVNSIAP--LARSAMTENVIPANILKELGPEKIAPLILYLTHENTKV 224
I P + + M ++V A + L P +A ++ +N K+
Sbjct: 262 RTTCICPFFIQATGMFDDV-NARWVPTLNPNDVADRVIAAIRKNEKL 307
Score = 71.6 bits (174), Expect = 5e-12
Identities = 50/173 (28%), Positives = 76/173 (43%), Gaps = 2/173 (1%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVA 366
P K L + +ITG G+GLG+ A+ + G KVVI DI + G
Sbjct: 80 PEKELNTDIALITGGGNGLGRLLAERLGKMGTKVVIWDINKKGIAETVQIVEEAGGYCKG 139
Query: 367 DTHDIVK--EAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTF 424
DI K E + D+ G + +L+NNAG++ + NV++ + F
Sbjct: 140 YVVDISKKEEVYKAADVIRDEVGDITLLINNAGVVSGLHLLDTPDHLIERSFNVNVMAHF 199
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
+KA P ++ G+I S +G G +Y A+K A +GF L LE
Sbjct: 200 WTTKAFLPKMIENDRGHIATIASLAGHVGISKLVDYCASKFAAVGFDEALRLE 252
>Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 266
Score = 77.0 bits (188), Expect = 1e-13
Identities = 58/211 (27%), Positives = 102/211 (47%), Gaps = 18/211 (8%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDE--INKKYGSGSAVADT 368
+ GKV ++TG+ G+G++ A+ GAKV + D + V + +++++ +
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKTLFIQ 62
Query: 369 HDIVKEAQ--QVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFAL 426
D+ + Q + VD FGR+DILVNNAG+ E W + ++L S +
Sbjct: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVISG 114
Query: 427 SKAVWPIFLKQ---KSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGT--KR 481
+ KQ + G IIN +S +G+ Q Y A+K I+GF+R+ AL
Sbjct: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNS 174
Query: 482 GITVNVIAP-HAETAMTKTIFSSKELNNHFD 511
G+ +N I P TA+ ++I + + + +
Sbjct: 175 GVRLNAICPGFVNTAILESIEKEENMGQYIE 205
Score = 69.3 bits (168), Expect = 2e-11
Identities = 60/202 (29%), Positives = 97/202 (47%), Gaps = 26/202 (12%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLG-------RSAADSVVQEIKKLGGEGDA 60
+V ++TGA G+GR +A +G KV + D ++A + K L + D
Sbjct: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKTLFIQCD- 64
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
VA+ + D +V+ +FGR+DIL+NNAG+ +EK +++ + ++L
Sbjct: 65 VADQQQLRDTFRKVVD----HFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVI 112
Query: 121 KLTRAAWPHMRKQKFGR---IINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
T +M KQ G IIN S AGL Q Y A+K G++GF S A
Sbjct: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLM 172
Query: 178 N--INVNSIAP-LARSAMTENV 196
N + +N+I P +A+ E++
Sbjct: 173 NSGVRLNAICPGFVNTAILESI 194
>CE05427 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 293
Score = 77.0 bits (188), Expect = 1e-13
Identities = 59/194 (30%), Positives = 92/194 (47%), Gaps = 13/194 (6%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSV-------VQEIKKLGGE 57
F + V ITGA G+G+ AL+ AK G +VV +A + EI+K GG
Sbjct: 11 FAGKTVFITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYTAAAEIEKAGGH 70
Query: 58 GDAVANYDSVSDNGA--AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVH 115
A+ V D A A V+ A+ FG +DILINNA + ++ K++ + ++
Sbjct: 71 --ALPCVVDVRDEAAVKAAVDAAVKKFGGIDILINNASAISLTNTEDTDMKRYDLMHSIN 128
Query: 116 LNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGN-FG-QANYSAAKLGLLGFGESLAKE 173
G + LT+ P+++K K ++N P + FG Y+ AK G+ +E
Sbjct: 129 TRGTYLLTKTCLPYLKKGKNPHVLNISPPLDMEAKWFGPHVGYTMAKFGMSMCVLGHHEE 188
Query: 174 GYKYNINVNSIAPL 187
Y I VN++ PL
Sbjct: 189 FRPYGIAVNALWPL 202
Score = 54.7 bits (130), Expect = 6e-07
Identities = 42/143 (29%), Positives = 68/143 (47%), Gaps = 13/143 (9%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVIN------DIRDPSAVVD---EINKKYGSGS 363
GK V ITG+ G+GK A A+ GA +V+ + P + EI K G
Sbjct: 13 GKTVFITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYTAAAEIEK--AGGH 70
Query: 364 AVADTHDIVKEA--QQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
A+ D+ EA + V AV KFG +DIL+NNA + + ++ + +++
Sbjct: 71 ALPCVVDVRDEAAVKAAVDAAVKKFGGIDILINNASAISLTNTEDTDMKRYDLMHSINTR 130
Query: 422 STFALSKAVWPIFLKQKSGYIIN 444
T+ L+K P K K+ +++N
Sbjct: 131 GTYLLTKTCLPYLKKGKNPHVLN 153
>At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 331
Score = 76.6 bits (187), Expect = 2e-13
Identities = 63/191 (32%), Positives = 90/191 (46%), Gaps = 10/191 (5%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA 60
+++ K R V ITG G+G A G KV + L RS + G
Sbjct: 31 VTIPIKFRHVFITGGSSGIGLALAHRAVSEGAKVSI--LARSTEKLAEAKRSIQLATGVE 88
Query: 61 VANYDS-VSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGA 119
VA + + V D A V AI G +D+LI N G+ K S ++ + +IDV+L G+
Sbjct: 89 VATFSADVRDYDA--VSKAIDESGPIDVLIVNQGVFIGKELEKQSPEEVKFMIDVNLTGS 146
Query: 120 FKLTRAAWPHMRKQKFGR----IINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGY 175
F + +AA P M K + GR I S AG G +G YSA+K GL G ++L +E
Sbjct: 147 FNVIKAALPAM-KAREGRGPASISLVSSQAGQAGIYGYTAYSASKFGLQGLAQALQQEVI 205
Query: 176 KYNINVNSIAP 186
I+V + P
Sbjct: 206 SDGIHVTLLFP 216
Score = 64.7 bits (156), Expect = 6e-10
Identities = 55/189 (29%), Positives = 90/189 (47%), Gaps = 9/189 (4%)
Query: 306 IPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAV 365
IPIK + V ITG SG+G + A GAKV I + + + +G V
Sbjct: 33 IPIKF---RHVFITGGSSGIGLALAHRAVSEGAKVSILARSTEKLAEAKRSIQLATGVEV 89
Query: 366 ADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
A V++ V A+D+ G +D+L+ N G+ + K + +E +I+V+L +F
Sbjct: 90 ATFSADVRD-YDAVSKAIDESGPIDVLIVNQGVFIGKELEKQSPEEVKFMIDVNLTGSFN 148
Query: 426 LSKAVWPIFLKQKSG----YIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
+ KA P +K + G I +S +G G +G Y+A+K + G ++ L E
Sbjct: 149 VIKAALPA-MKAREGRGPASISLVSSQAGQAGIYGYTAYSASKFGLQGLAQALQQEVISD 207
Query: 482 GITVNVIAP 490
GI V ++ P
Sbjct: 208 GIHVTLLFP 216
>CE26808_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 550
Score = 76.6 bits (187), Expect = 2e-13
Identities = 57/192 (29%), Positives = 88/192 (45%), Gaps = 13/192 (6%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLG--GEGDAVA 62
F +V ++TG+ G+GR AL +A++G KV + + Q I K G E
Sbjct: 219 FSGKVALVTGSSNGIGRAAALLFAQQGAKVTITGRNAERLEETRQAILKSGVPAENVLAI 278
Query: 63 NYDSVSDNGAA-IVETAISNFGRVDILINNAGILRDSSFAKMSEKQ----FQQVIDVHLN 117
D +D G ++ + FGR+DIL+NNAG + +M Q F + +++
Sbjct: 279 AADLATDQGQTDLINGTLQKFGRLDILVNNAGAAVNDPQGRMGIDQQIEDFDKTFQINMR 338
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQAN---YSAAKLGLLGFGESLAKEG 174
L + A H+ K K G IIN S G G Q + Y +K L F S A
Sbjct: 339 SVVTLVQKAKEHLIKTK-GEIINVSSIGG--GPHAQPDMMYYGMSKAALDQFTRSTAITL 395
Query: 175 YKYNINVNSIAP 186
++ + VNS++P
Sbjct: 396 IQHGVRVNSVSP 407
Score = 71.6 bits (174), Expect = 5e-12
Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 13/189 (6%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSG----SAVADT 368
GKV ++TGS +G+G++ A FA+ GAKV I R+ + + SG + +A
Sbjct: 221 GKVALVTGSSNGIGRAAALLFAQQGAKVTITG-RNAERLEETRQAILKSGVPAENVLAIA 279
Query: 369 HDIVKEAQQ--VVQTAVDKFGRVDILVNNAGILRDRSFAKMTED----EWNAVINVHLFS 422
D+ + Q ++ + KFGR+DILVNNAG + +M D +++ +++ S
Sbjct: 280 ADLATDQGQTDLINGTLQKFGRLDILVNNAGAAVNDPQGRMGIDQQIEDFDKTFQINMRS 339
Query: 423 TFALSKAVWPIFLKQKSGYIINTTST-SGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
L + +K K G IIN +S G + Y +KAA+ F+R+ A+ +
Sbjct: 340 VVTLVQKAKEHLIKTK-GEIINVSSIGGGPHAQPDMMYYGMSKAALDQFTRSTAITLIQH 398
Query: 482 GITVNVIAP 490
G+ VN ++P
Sbjct: 399 GVRVNSVSP 407
>At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 305
Score = 76.6 bits (187), Expect = 2e-13
Identities = 63/195 (32%), Positives = 94/195 (47%), Gaps = 20/195 (10%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDI-----RDPSAVVDEINKKYGSG----S 363
G ++TG SG+G++ A G V + D ++ +++V E N K+ G S
Sbjct: 6 GLSALVTGGASGIGRALCLALAEKGVFVTVADFSEEKGQETTSLVREANAKFHQGLSFPS 65
Query: 364 AVADTHDIVKEAQQVVQTAVDK----FGRVDILVNNAGILRDRSFAKMTED---EWNAVI 416
A+ D+ + A DK FG +DI +NNAGI F K D W I
Sbjct: 66 AIFVKCDVTNRGDLLA--AFDKHLATFGTLDICINNAGISTPLRFDKDDTDGSKSWKHTI 123
Query: 417 NVHLFSTF-ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLA 475
NV L + A+ + KQK G IIN S +G+Y YAA+KA ++ F+R+LA
Sbjct: 124 NVDLIAVVEGTQLAIKAMKAKQKPGVIINMGSAAGLYPMPVDPIYAASKAGVVLFTRSLA 183
Query: 476 LEGTKRGITVNVIAP 490
++GI +NV+ P
Sbjct: 184 YY-RRQGIRINVLCP 197
Score = 70.1 bits (170), Expect = 1e-11
Identities = 62/209 (29%), Positives = 95/209 (44%), Gaps = 14/209 (6%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDS---- 66
++TG G+GR L A++G V V D +++ + ++ S
Sbjct: 10 LVTGGASGIGRALCLALAEKGVFVTVADFSEEKGQETTSLVREANAKFHQGLSFPSAIFV 69
Query: 67 ---VSDNG--AAIVETAISNFGRVDILINNAGILRDSSFAKMS---EKQFQQVIDVHLNG 118
V++ G A + ++ FG +DI INNAGI F K K ++ I+V L
Sbjct: 70 KCDVTNRGDLLAAFDKHLATFGTLDICINNAGISTPLRFDKDDTDGSKSWKHTINVDLIA 129
Query: 119 AFKLTRAAWPHMR-KQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
+ T+ A M+ KQK G IIN S AGLY Y+A+K G++ F SLA +
Sbjct: 130 VVEGTQLAIKAMKAKQKPGVIINMGSAAGLYPMPVDPIYAASKAGVVLFTRSLAYY-RRQ 188
Query: 178 NINVNSIAPLARSAMTENVIPANILKELG 206
I +N + P I A+IL+ +G
Sbjct: 189 GIRINVLCPEFIKTDLAEAIDASILESIG 217
>SPAC22A12.17c [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 76.3 bits (186), Expect = 2e-13
Identities = 57/194 (29%), Positives = 90/194 (46%), Gaps = 5/194 (2%)
Query: 306 IPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKV-VINDIRDPSAVVDEINKKYGSGSA 364
+ + SL+GK ++ G G+G + FA GA ++ + EI + G +
Sbjct: 14 LDLLSLKGKNAVVFGGARGIGHAICSVFAEAGANAFIVYNTTPGEKAAKEIAQANGVKTY 73
Query: 365 VADTH-DIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFST 423
I KE + F +DI+V N GI +S MT +E+ INV+L
Sbjct: 74 TCKCDVTIPKEVEHAFAEIQKVFDTIDIVVPNNGICTGKSAIDMTYEEFANEINVNLLGV 133
Query: 424 FALSKAVWPIFLKQKSGYIINTTSTSGIYGNF--GQCNYAAAKAAILGFSRTLALEGTKR 481
F ++ PIF KQ G ++ T S SG+ N QC Y +KA ++ ++LA+E K
Sbjct: 134 FNVAHNAGPIFQKQGHGSLVATASMSGVVVNVPQQQCAYNTSKAGVIQLIKSLAVEWRKF 193
Query: 482 GITVNVIAPHAETA 495
VN ++P T+
Sbjct: 194 A-RVNCVSPGYTTS 206
Score = 62.4 bits (150), Expect = 3e-09
Identities = 59/250 (23%), Positives = 100/250 (39%), Gaps = 18/250 (7%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVA 62
L K + ++ G G+G +A+ G + + + +EI + G
Sbjct: 17 LSLKGKNAVVFGGARGIGHAICSVFAEAGANAFIV-YNTTPGEKAAKEIAQANGVKTYTC 75
Query: 63 NYDSVSDNGAAIVETAISN-FGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFK 121
D I F +DI++ N GI S M+ ++F I+V+L G F
Sbjct: 76 KCDVTIPKEVEHAFAEIQKVFDTIDIVVPNNGICTGKSAIDMTYEEFANEINVNLLGVFN 135
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQAN--YSAAKLGLLGFGESLAKEGYKYNI 179
+ A P +KQ G ++ T S +G+ N Q Y+ +K G++ +SLA E K+
Sbjct: 136 VAHNAGPIFQKQGHGSLVATASMSGVVVNVPQQQCAYNTSKAGVIQLIKSLAVEWRKF-A 194
Query: 180 NVNSIAPLARSAMTENVIPANILKELGP----------EKIAPLILYLTHENTKVTNNIF 229
VN ++P T ++ KE P ++IA LYL + +
Sbjct: 195 RVNCVSP---GYTTSDMTGGKFHKEWEPYTPFERNGLAKEIASAYLYLASDAASYASGTN 251
Query: 230 ELAAGFYSQI 239
+ G Y+ I
Sbjct: 252 LIVDGGYTSI 261
>CE20725 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 76.3 bits (186), Expect = 2e-13
Identities = 55/190 (28%), Positives = 89/190 (45%), Gaps = 9/190 (4%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLG--GEGDAVA 62
F +V +ITG+ G+GR A+ +A++G KV + EIKK G E
Sbjct: 4 FSGKVALITGSSNGIGRAAAILFAQQGAKVTITGRNAERLKETRHEIKKSGIPAENILAI 63
Query: 63 NYDSVSDNG-AAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ----FQQVIDVHLN 117
D ++D G ++ + FG +DIL+NNAG + ++ Q F + +++
Sbjct: 64 VADVITDEGQMRLINDTVRKFGHLDILVNNAGGALMDAQGRVGMDQDISVFDNTMQINMR 123
Query: 118 GAFKLTRAAWPHMRKQKFGRIIN-TCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYK 176
L + A H+ K K G IIN + AG +G+ Y +K L F S A +
Sbjct: 124 SVVTLVQKAKEHLIKSK-GEIINVSAMAAGHHGDPIATFYGMSKAALDQFTRSSAISLIQ 182
Query: 177 YNINVNSIAP 186
+ + VNS++P
Sbjct: 183 HGVRVNSVSP 192
Score = 72.0 bits (175), Expect = 4e-12
Identities = 62/200 (31%), Positives = 107/200 (53%), Gaps = 17/200 (8%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSG----SAVADT 368
GKV +ITGS +G+G++ A FA+ GAKV I R+ + + ++ SG + +A
Sbjct: 6 GKVALITGSSNGIGRAAAILFAQQGAKVTITG-RNAERLKETRHEIKKSGIPAENILAIV 64
Query: 369 HDIVKEAQQ--VVQTAVDKFGRVDILVNNAG--ILRDRSFAKMTED--EWNAVINVHLFS 422
D++ + Q ++ V KFG +DILVNNAG ++ + M +D ++ + +++ S
Sbjct: 65 ADVITDEGQMRLINDTVRKFGHLDILVNNAGGALMDAQGRVGMDQDISVFDNTMQINMRS 124
Query: 423 TFALSKAVWPIFLKQKSGYIINTTS-TSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
L + +K K G IIN ++ +G +G+ Y +KAA+ F+R+ A+ +
Sbjct: 125 VVTLVQKAKEHLIKSK-GEIINVSAMAAGHHGDPIATFYGMSKAALDQFTRSSAISLIQH 183
Query: 482 GITVNVIAPHAETAMTKTIF 501
G+ VN ++P TKT F
Sbjct: 184 GVRVNSVSP----GFTKTGF 199
>CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 258
Score = 76.3 bits (186), Expect = 2e-13
Identities = 62/197 (31%), Positives = 100/197 (50%), Gaps = 19/197 (9%)
Query: 308 IKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGS--GSAV 365
++S +G V ++TG SGLGK A+ A+ GA+V I D+ P + ++ K+ G A
Sbjct: 4 LRSTKGLVALVTGGASGLGKGAAEVLAKAGAQVAILDL--PQSKGADVAKEIGGIFTPAS 61
Query: 366 ADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGI---LRDRSFAKMTEDEWNAV---INVH 419
+ + V+ A VQ ++GR+D LVN AGI + S K ++ + I+V+
Sbjct: 62 VTSEEEVRAAFAKVQA---EYGRLDALVNCAGIAYAFKLYSVQKKKHVDFEKIRQTIDVN 118
Query: 420 LFSTFALSKAVWPIFLKQKS------GYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRT 473
+ TF + + + + + G +INT S + G GQ Y+A+K AI+G +
Sbjct: 119 VLGTFNVIRHGVALMGEHEKDANGQRGVVINTASVAAFDGQTGQSAYSASKGAIVGMTLP 178
Query: 474 LALEGTKRGITVNVIAP 490
LA + GI N IAP
Sbjct: 179 LARDFAGDGIRFNTIAP 195
Score = 74.3 bits (181), Expect = 8e-13
Identities = 69/237 (29%), Positives = 105/237 (44%), Gaps = 17/237 (7%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
K V ++TG GLG+ A AK G +V + DL +S V +EI G A+
Sbjct: 8 KGLVALVTGGASGLGKGAAEVLAKAGAQVAILDLPQSKGADVAKEI----GGIFTPASVT 63
Query: 66 SVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ------FQQVIDVHLNGA 119
S + AA + + +GR+D L+N AGI + +K+ +Q IDV++ G
Sbjct: 64 SEEEVRAAFAKVQ-AEYGRLDALVNCAGIAYAFKLYSVQKKKHVDFEKIRQTIDVNVLGT 122
Query: 120 FKLTRAAWPHMRKQKF------GRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
F + R M + + G +INT S A G GQ+ YSA+K ++G LA++
Sbjct: 123 FNVIRHGVALMGEHEKDANGQRGVVINTASVAAFDGQTGQSAYSASKGAIVGMTLPLARD 182
Query: 174 GYKYNINVNSIAPLARSAMTENVIPANILKELGPEKIAPLILYLTHENTKVTNNIFE 230
I N+IAP + +P + L P L HE + +I E
Sbjct: 183 FAGDGIRFNTIAPGLMDTPLLSSLPEKVKSFLAQLIPNPSRLGHPHEYGALVQHIIE 239
>Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 75.9 bits (185), Expect = 3e-13
Identities = 46/165 (27%), Positives = 77/165 (45%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVS 68
+V+ITGAG G+GR E+AKR +V+ D+ + + E +KLG A S
Sbjct: 38 IVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNR 97
Query: 69 DNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWP 128
+ + G V I++NNAG + + +++ + +V++ G F +T+A P
Sbjct: 98 EEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLP 157
Query: 129 HMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
M ++ G I+ S G G Y ++K +GF L E
Sbjct: 158 SMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSE 202
Score = 68.9 bits (167), Expect = 3e-11
Identities = 54/196 (27%), Positives = 89/196 (44%), Gaps = 6/196 (3%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDI--RDPSAVVDEINKKYGSGSAVA 366
KS+ G++V+ITG+G G+G+ FA+ + +V+ DI R E K + A
Sbjct: 32 KSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYV 91
Query: 367 DTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFAL 426
+E + + + G V I+VNNAG + ++E V++ F +
Sbjct: 92 VDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWI 151
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGT---KRGI 483
+KA+ P +++ G+I+ S G G Y ++K A +GF R L E K GI
Sbjct: 152 TKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGI 211
Query: 484 TVNVIAP-HAETAMTK 498
+ + P T TK
Sbjct: 212 KTSCLCPVFVNTGFTK 227
>Hs19923817 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 75.9 bits (185), Expect = 3e-13
Identities = 54/196 (27%), Positives = 98/196 (49%), Gaps = 11/196 (5%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVI--NDIRDPSAVVDEINK-----KYGSGS 363
L+G+V I+TG +G+GK+ + G+ VVI + + DE+ K
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 364 AVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFST 423
+ +E +V++ +D FG+++ LVNN G ++ W+AV+ +L T
Sbjct: 76 PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
Query: 424 FALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
F + KAV+ ++K+ G I+N + G + AA+A + +++LALE GI
Sbjct: 136 FYMCKAVYSSWMKEHGGSIVNIIVPTKA-GFPLAVHSGAARAGVYNLTKSLALEWACSGI 194
Query: 484 TVNVIAP---HAETAM 496
+N +AP +++TA+
Sbjct: 195 RINCVAPGVIYSQTAV 210
Score = 62.4 bits (150), Expect = 3e-09
Identities = 50/189 (26%), Positives = 86/189 (45%), Gaps = 16/189 (8%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIK-KLGGEGDA------ 60
+V I+TG G+G+ E + G VV+ S E++ L A
Sbjct: 19 QVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQ 78
Query: 61 --VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNG 118
+ N + V++ +V++ + FG+++ L+NN G S +S K + V++ +L G
Sbjct: 79 CNIRNEEEVNN----LVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTG 134
Query: 119 AFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYS-AAKLGLLGFGESLAKEGYKY 177
F + +A + K+ G I+N P F A +S AA+ G+ +SLA E
Sbjct: 135 TFYMCKAVYSSWMKEHGGSIVNIIVPT--KAGFPLAVHSGAARAGVYNLTKSLALEWACS 192
Query: 178 NINVNSIAP 186
I +N +AP
Sbjct: 193 GIRINCVAP 201
>CE15574 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 75.9 bits (185), Expect = 3e-13
Identities = 56/192 (29%), Positives = 93/192 (48%), Gaps = 13/192 (6%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANY 64
F +V ++TG+ G+GR A+ A+ G KV + + QEI + G D V +
Sbjct: 4 FSGKVALVTGSSNGIGRATAILLAREGAKVTITGRNAQRLEETKQEILRSGVPEDHVLSI 63
Query: 65 --DSVSDNG-AAIVETAISNFGRVDILINNAGI----LRDSSFAKMSEKQFQQVIDVHLN 117
D +++G ++ + + FGR+DIL+NNAG L + F + + ++L
Sbjct: 64 IADLATESGQIELMNSTVDIFGRLDILVNNAGAAITDLEGHIGVGTNVSVFDKTMRINLR 123
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQAN---YSAAKLGLLGFGESLAKEG 174
LT+ A H+ K K G I+N S AG G Q Y+ +K L + S A +
Sbjct: 124 SVVTLTQKAKEHLIKTK-GEIVNVSSIAG--GQHAQPELIYYAMSKSALDQYTRSAAIDL 180
Query: 175 YKYNINVNSIAP 186
++ + VNS++P
Sbjct: 181 IQHGVRVNSVSP 192
Score = 73.9 bits (180), Expect = 1e-12
Identities = 65/209 (31%), Positives = 107/209 (51%), Gaps = 22/209 (10%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTH--- 369
GKV ++TGS +G+G++ A AR GAKV I +A E K+ S V + H
Sbjct: 6 GKVALVTGSSNGIGRATAILLAREGAKVTIT---GRNAQRLEETKQEILRSGVPEDHVLS 62
Query: 370 ---DIVKEAQQV--VQTAVDKFGRVDILVNNAGI----LRDRSFAKMTEDEWNAVINVHL 420
D+ E+ Q+ + + VD FGR+DILVNNAG L ++ + ++L
Sbjct: 63 IIADLATESGQIELMNSTVDIFGRLDILVNNAGAAITDLEGHIGVGTNVSVFDKTMRINL 122
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQ---CNYAAAKAAILGFSRTLALE 477
S L++ +K K G I+N +S +G G Q YA +K+A+ ++R+ A++
Sbjct: 123 RSVVTLTQKAKEHLIKTK-GEIVNVSSIAG--GQHAQPELIYYAMSKSALDQYTRSAAID 179
Query: 478 GTKRGITVNVIAP-HAETAMTKTIFSSKE 505
+ G+ VN ++P T + +T+ +KE
Sbjct: 180 LIQHGVRVNSVSPGDIRTGIYETMGMNKE 208
>SPAC8E11.10 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 255
Score = 75.5 bits (184), Expect = 3e-13
Identities = 59/198 (29%), Positives = 97/198 (48%), Gaps = 13/198 (6%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAV--VDEINKKYG-----SG 362
SL+GK +ITG G+G S A+ FA G+ V + R+ A+ E+ K+G
Sbjct: 6 SLKGKTTLITGGSGGIGFSIAKAFAAAGSNVGLLYGRNKKALEYAAELRDKHGVQAKAYS 65
Query: 363 SAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGI-LRDRSFAKMTEDEWNAVINVHLF 421
+ + +++ Q V+ + GR+D+++ NAGI + S ED W V+ ++L
Sbjct: 66 CPIENRSAVIETTNQAVE---ELGGRLDVMIANAGIAIPHLSLEDKNEDIWTKVVGINLN 122
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQ--CNYAAAKAAILGFSRTLALEGT 479
+ ++A F KQ G +I T S SG N+ Q +Y A KAA+ +R LA+E
Sbjct: 123 GAYYTAQAAGHHFKKQGKGSLIFTASMSGHIANWPQQWASYHATKAAVKHLARALAVEWA 182
Query: 480 KRGITVNVIAPHAETAMT 497
+V + +T +T
Sbjct: 183 PFARVNSVSPGYIDTDLT 200
Score = 74.3 bits (181), Expect = 8e-13
Identities = 59/189 (31%), Positives = 96/189 (50%), Gaps = 12/189 (6%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKV-VVNDLGRSAADSVVQEIKKLGGEGDAVANY 64
K + +ITG GG+G A +A G V ++ + A + + K G + A Y
Sbjct: 8 KGKTTLITGGSGGIGFSIAKAFAAAGSNVGLLYGRNKKALEYAAELRDKHGVQAKA---Y 64
Query: 65 DSVSDNGAAIVET---AISNFG-RVDILINNAGI-LRDSSFAKMSEKQFQQVIDVHLNGA 119
+N +A++ET A+ G R+D++I NAGI + S +E + +V+ ++LNGA
Sbjct: 65 SCPIENRSAVIETTNQAVEELGGRLDVMIANAGIAIPHLSLEDKNEDIWTKVVGINLNGA 124
Query: 120 FKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQ--ANYSAAKLGLLGFGESLAKEGYKY 177
+ +AA H +KQ G +I T S +G N+ Q A+Y A K + +LA E +
Sbjct: 125 YYTAQAAGHHFKKQGKGSLIFTASMSGHIANWPQQWASYHATKAAVKHLARALAVEWAPF 184
Query: 178 NINVNSIAP 186
VNS++P
Sbjct: 185 -ARVNSVSP 192
>CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 347
Score = 75.5 bits (184), Expect = 3e-13
Identities = 60/193 (31%), Positives = 85/193 (43%), Gaps = 15/193 (7%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVV-----VNDLGRSAADSVV------QEIKK 53
F R I+TG G+G A+ +RG V V DL ++ AD V Q K
Sbjct: 36 FFRRHAIVTGGSKGIGFQLAVGLIERGCHVTIVARNVKDLEKACADLQVLADQRGQRQKV 95
Query: 54 LGGEGDAVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVID 113
D YD + + + A G +DILINNAG + F ++ F++ +
Sbjct: 96 HWKSIDMTGGYDVIK----SAFDDAARELGPIDILINNAGHSVQAPFCELPITDFEKQMA 151
Query: 114 VHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
V+ A TRA M+ +K G I S AG + FG + YS K L GF ++L E
Sbjct: 152 VNYLSAVHATRAVVDDMKTRKTGHISFVSSAAGQFAIFGYSAYSPTKFALRGFADTLHME 211
Query: 174 GYKYNINVNSIAP 186
Y +NV + P
Sbjct: 212 LLPYKVNVGVLYP 224
Score = 58.9 bits (141), Expect = 3e-08
Identities = 48/186 (25%), Positives = 80/186 (42%), Gaps = 15/186 (8%)
Query: 317 IITGSGSGLGKSHAQWFARYGAKVVI-----NDIRDPSAVVDEINKKYGSGSAV------ 365
I+TG G+G A G V I D+ A + + + G V
Sbjct: 42 IVTGGSKGIGFQLAVGLIERGCHVTIVARNVKDLEKACADLQVLADQRGQRQKVHWKSID 101
Query: 366 -ADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTF 424
+D++K A A + G +DIL+NNAG F ++ ++ + V+ S
Sbjct: 102 MTGGYDVIKSA---FDDAARELGPIDILINNAGHSVQAPFCELPITDFEKQMAVNYLSAV 158
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
++AV +K+G+I +S +G + FG Y+ K A+ GF+ TL +E +
Sbjct: 159 HATRAVVDDMKTRKTGHISFVSSAAGQFAIFGYSAYSPTKFALRGFADTLHMELLPYKVN 218
Query: 485 VNVIAP 490
V V+ P
Sbjct: 219 VGVLYP 224
>At2g29150 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 75.5 bits (184), Expect = 3e-13
Identities = 59/202 (29%), Positives = 101/202 (49%), Gaps = 7/202 (3%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTH 369
SL G ++TG GLG++ + A GA+V RD + + + + + G V +
Sbjct: 15 SLEGMTALVTGGSKGLGEAVVEELAMLGARVH-TCARDETQLQERLREWQAKGFEVTTSV 73
Query: 370 DIVKEAQQ---VVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
V +Q +++T F G+++ILVNNAG + + T ++++ ++ +L S F
Sbjct: 74 CDVSSREQREKLMETVSSVFQGKLNILVNNAGTGIIKPSTEYTAEDYSFLMATNLESAFH 133
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
LS+ P+ SG I+ +S +G+ + G Y A+K A+ R+LA E I V
Sbjct: 134 LSQIAHPLLKASGSGSIVFMSSVAGLV-HTGASIYGASKGAMNQLGRSLACEWASDNIRV 192
Query: 486 NVIAPHA-ETAMTKTIFSSKEL 506
N + P T +T IFS ++L
Sbjct: 193 NSVCPWVITTPLTSFIFSDEKL 214
Score = 62.8 bits (151), Expect = 2e-09
Identities = 51/177 (28%), Positives = 82/177 (45%), Gaps = 2/177 (1%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TG GLG E A G +V + ++E + G E S +
Sbjct: 22 LVTGGSKGLGEAVVEELAMLGARVHTCARDETQLQERLREWQAKGFEVTTSVCDVSSREQ 81
Query: 71 GAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
++ET S F G+++IL+NNAG + + + + ++ +L AF L++ A P
Sbjct: 82 REKLMETVSSVFQGKLNILVNNAGTGIIKPSTEYTAEDYSFLMATNLESAFHLSQIAHPL 141
Query: 130 MRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
++ G I+ S AGL + G + Y A+K + G SLA E NI VNS+ P
Sbjct: 142 LKASGSGSIVFMSSVAGLV-HTGASIYGASKGAMNQLGRSLACEWASDNIRVNSVCP 197
>At5g50770 [Q] KOG1205 Predicted dehydrogenase
Length = 342
Score = 75.1 bits (183), Expect = 4e-13
Identities = 59/203 (29%), Positives = 111/203 (54%), Gaps = 9/203 (4%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIR-DPSAVVDEINKKYGSGSAVAD 367
+++ GKVV+ITG+ SG+G++ A + + GA + + DIR +P V + + YGS +
Sbjct: 43 ENVAGKVVVITGAASGIGEALAYEYGKRGAYLALVDIRGEPLFHVAALAELYGSPEVLPL 102
Query: 368 THDIVK--EAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTE-DEWNAVINVHLFSTF 424
D+ K + ++ ++ V FGR+D LV NAG+ FA + + + + ++++ + +
Sbjct: 103 VADVSKLQDCERFIRATVLHFGRLDHLVTNAGVAPLYFFADIEDVSKASPAMDINFWGSV 162
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE-GTKRGI 483
+ P +LK+ G I+ S G + Y A+KAA++ F TL E G+ G+
Sbjct: 163 YCTFFASP-YLKKFRGRIVVIASGCGYIASPRLSFYCASKAAVIAFYETLRTEFGSDIGV 221
Query: 484 TVNVIAPH-AETAMTKTIFSSKE 505
T ++AP ++ M++ F +K+
Sbjct: 222 T--IVAPGIVDSEMSRGKFMTKD 242
Score = 68.9 bits (167), Expect = 3e-11
Identities = 53/182 (29%), Positives = 91/182 (49%), Gaps = 6/182 (3%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+VV+ITGA G+G A EY KRG + + D+ R V + +L G + + V
Sbjct: 48 KVVVITGAASGIGEALAYEYGKRGAYLALVDI-RGEPLFHVAALAELYGSPEVLPLVADV 106
Query: 68 S--DNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSE-KQFQQVIDVHLNGAFKLTR 124
S + + + +FGR+D L+ NAG+ FA + + + +D++ G+ T
Sbjct: 107 SKLQDCERFIRATVLHFGRLDHLVTNAGVAPLYFFADIEDVSKASPAMDINFWGSVYCTF 166
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSI 184
A P+++K + GRI+ S G + + Y A+K ++ F E+L E + +I V +
Sbjct: 167 FASPYLKKFR-GRIVVIASGCGYIASPRLSFYCASKAAVIAFYETLRTE-FGSDIGVTIV 224
Query: 185 AP 186
AP
Sbjct: 225 AP 226
>7296706_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 233
Score = 75.1 bits (183), Expect = 4e-13
Identities = 44/123 (35%), Positives = 71/123 (56%), Gaps = 3/123 (2%)
Query: 370 DIVKEA--QQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALS 427
D+ KEA QQ+V + K GR+D+LVNNAGIL S + ++++ ++N ++ S + L+
Sbjct: 40 DMTKEAEVQQIVGATLAKHGRIDVLVNNAGILETGSIEATSLEQFDRLMNTNVRSLYQLT 99
Query: 428 KAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNV 487
P +K K G I+N +S G+ G Y +KAA+ F+ +ALE +G+ VN
Sbjct: 100 MLATPELVKTK-GNIVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNA 158
Query: 488 IAP 490
+ P
Sbjct: 159 VNP 161
Score = 67.8 bits (164), Expect = 7e-11
Identities = 46/160 (28%), Positives = 72/160 (44%), Gaps = 2/160 (1%)
Query: 28 AKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDNGAA-IVETAISNFGRVD 86
AK GG +V+ I GG D + IV ++ GR+D
Sbjct: 3 AKLGGLLVIVGRNEEKLKETADNIVAAGGATPLELQADMTKEAEVQQIVGATLAKHGRID 62
Query: 87 ILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAG 146
+L+NNAGIL S S +QF ++++ ++ ++LT A P + K K G I+N S G
Sbjct: 63 VLVNNAGILETGSIEATSLEQFDRLMNTNVRSLYQLTMLATPELVKTK-GNIVNVSSVCG 121
Query: 147 LYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
L G Y+ +K + F +A E + VN++ P
Sbjct: 122 LRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNP 161
>Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 332
Score = 74.7 bits (182), Expect = 6e-13
Identities = 50/189 (26%), Positives = 92/189 (48%), Gaps = 19/189 (10%)
Query: 10 VIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEG----------- 58
V++TG G+G+ A+E K+G + + + R+ D ++Q K++
Sbjct: 35 VVVTGGSSGIGKCIAIECYKQGAFITL--VARNE-DKLLQAKKEIEMHSINDKQVVLCIS 91
Query: 59 -DAVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLN 117
D +Y+ V + +++ A G VD+L+N AG+ F + F++++ ++
Sbjct: 92 VDVSQDYNQVEN----VIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYL 147
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
G+ +RA M++++ GRI+ S AG G FG YSA+K + G E+L E Y
Sbjct: 148 GSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPY 207
Query: 178 NINVNSIAP 186
N+ + P
Sbjct: 208 NVYITVAYP 216
Score = 66.2 bits (160), Expect = 2e-10
Identities = 50/193 (25%), Positives = 89/193 (45%), Gaps = 8/193 (4%)
Query: 305 PIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAV-------VDEINK 357
P P+ +L G V++TG SG+GK A + GA + + + + + IN
Sbjct: 25 PKPL-ALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSIND 83
Query: 358 KYGSGSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVIN 417
K D + + V++ A +K G VD+LVN AG+ F + + +++
Sbjct: 84 KQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMS 143
Query: 418 VHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
++ + S+AV +++ G I+ +S +G G FG Y+A+K AI G + L +E
Sbjct: 144 INYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQME 203
Query: 478 GTKRGITVNVIAP 490
+ + V P
Sbjct: 204 VKPYNVYITVAYP 216
>7296704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 74.7 bits (182), Expect = 6e-13
Identities = 54/182 (29%), Positives = 99/182 (53%), Gaps = 6/182 (3%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSG-SAVADTHDI 371
GKVV+ITG+ SG+G + A+ F++ GA + + D R+ ++ + + G D+
Sbjct: 13 GKVVLITGAASGIGAAAAEMFSKLGACLALVD-REEEGLICVMKRCMKMGHEPYGIAGDL 71
Query: 372 VK--EAQQVVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSK 428
+K E + + + +++ G++D+LVN AGI+ + + V+ ++ S F L+K
Sbjct: 72 LKPPEIECIARKTTERYEGKLDVLVNGAGIMPTGTLQSTELACFTHVMEANVRSGFYLTK 131
Query: 429 AVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVI 488
+ P L+ K G I+N +S G+ Y +KAA+ F+R+LAL+ +G+ VN +
Sbjct: 132 LLLPQLLQCK-GSIVNVSSVCGLRAFPNLVAYNMSKAAVDQFTRSLALDLGPQGVRVNAV 190
Query: 489 AP 490
P
Sbjct: 191 NP 192
Score = 68.6 bits (166), Expect = 4e-11
Identities = 49/185 (26%), Positives = 83/185 (44%), Gaps = 2/185 (1%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVA 62
L+F +VV+ITGA G+G A ++K G + + D V++ K+G E +A
Sbjct: 9 LDFSGKVVLITGAASGIGAAAAEMFSKLGACLALVDREEEGLICVMKRCMKMGHEPYGIA 68
Query: 63 NYDSVSDNGAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFK 121
I + G++D+L+N AGI+ + F V++ ++ F
Sbjct: 69 GDLLKPPEIECIARKTTERYEGKLDVLVNGAGIMPTGTLQSTELACFTHVMEANVRSGFY 128
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINV 181
LT+ P + + K G I+N S GL Y+ +K + F SLA + + V
Sbjct: 129 LTKLLLPQLLQCK-GSIVNVSSVCGLRAFPNLVAYNMSKAAVDQFTRSLALDLGPQGVRV 187
Query: 182 NSIAP 186
N++ P
Sbjct: 188 NAVNP 192
>CE02490_1 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 302
Score = 74.7 bits (182), Expect = 6e-13
Identities = 57/195 (29%), Positives = 93/195 (47%), Gaps = 13/195 (6%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAAD-------SVVQEIKKLGG 56
+F R V+ITGA G+G+ AL+ AK G +VV +A S +EI+K GG
Sbjct: 6 KFVGRTVLITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYSAAEEIEKAGG 65
Query: 57 EGDAVANYDSVSDNGA--AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDV 114
+ A+ V D + A VE A+ FG +DILINNA + + K++ + +
Sbjct: 66 K--ALPCIVDVRDEASVKASVEEAVKKFGGIDILINNASAISLTDTENTEMKRYDLMHSI 123
Query: 115 HLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNF--GQANYSAAKLGLLGFGESLAK 172
+ G F +T+ P+++ K ++N P + + Y+ AK G+ +
Sbjct: 124 NTRGTFLMTKTCLPYLKSGKNPHVLNISPPLLMETRWFANHVAYTMAKYGMSMCVLGQHE 183
Query: 173 EGYKYNINVNSIAPL 187
E + I VN++ PL
Sbjct: 184 EFRPHGIAVNALWPL 198
Score = 54.7 bits (130), Expect = 6e-07
Identities = 52/192 (27%), Positives = 84/192 (43%), Gaps = 17/192 (8%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVI---NDIRDPS------AVVDEINKKYGSGS 363
G+ V+ITG+ G+GK A A+ GA +V+ P + +EI K G
Sbjct: 9 GRTVLITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYSAAEEIEK--AGGK 66
Query: 364 AVADTHDIVKEA--QQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
A+ D+ EA + V+ AV KFG +DIL+NNA + ++ + +++
Sbjct: 67 ALPCIVDVRDEASVKASVEEAVKKFGGIDILINNASAISLTDTENTEMKRYDLMHSINTR 126
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLA---LEG 478
TF ++K P K+ +++N S + N+ A A G S + E
Sbjct: 127 GTFLMTKTCLPYLKSGKNPHVLN-ISPPLLMETRWFANHVAYTMAKYGMSMCVLGQHEEF 185
Query: 479 TKRGITVNVIAP 490
GI VN + P
Sbjct: 186 RPHGIAVNALWP 197
>Hs5031737 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 73.9 bits (180), Expect = 1e-12
Identities = 64/205 (31%), Positives = 105/205 (51%), Gaps = 7/205 (3%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
L +V ++TGS SG+G + A+ AR GA VVI+ R V + K G G +VA
Sbjct: 34 LANRVAVVTGSTSGIGFAIARRLARDGAHVVISS-RKQQNVDRAMAKLQGEGLSVAGIVC 92
Query: 371 IVKEAQ---QVVQTAVDKFGRVDILVNNAGILR-DRSFAKMTEDEWNAVINVHLFSTFAL 426
V +A+ Q+V A++ G VD LV +AG+ S +E W+ +++V++ S L
Sbjct: 93 HVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALL 152
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
+ P +++ + G +I +S + Y +K A+LG +RTLALE + I VN
Sbjct: 153 LSQLLP-YMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVN 211
Query: 487 VIAPH-AETAMTKTIFSSKELNNHF 510
+ P +T +K ++ L +F
Sbjct: 212 CVVPGIIKTDFSKVFHGNESLWKNF 236
Score = 60.8 bits (146), Expect = 9e-09
Identities = 51/185 (27%), Positives = 90/185 (48%), Gaps = 10/185 (5%)
Query: 7 DRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVAN--- 63
+RV ++TG+ G+G A A+ G VV++ + D + + KL GEG +VA
Sbjct: 36 NRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVD---RAMAKLQGEGLSVAGIVC 92
Query: 64 YDSVSDNGAAIVETAISNFGRVDILINNAGI--LRDSSFAKMSEKQFQQVIDVHLNGAFK 121
+ +++ +V A+ + G VD L+ +AG+ L S+ SE+ + +++ V++
Sbjct: 93 HVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLG-TSEQIWDKILSVNVKSPAL 151
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINV 181
L P+M ++ G +I S A Y+ +K LLG +LA E +I V
Sbjct: 152 LLSQLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210
Query: 182 NSIAP 186
N + P
Sbjct: 211 NCVVP 215
>CE12594 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 73.9 bits (180), Expect = 1e-12
Identities = 66/199 (33%), Positives = 99/199 (49%), Gaps = 35/199 (17%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVIN------------DIRDPSAVVDEINKKYG 360
GK +IITGS SG+G+S A FA+ GA+V I I ++IN
Sbjct: 6 GKSIIITGSSSGIGRSAAVIFAKEGAQVTITGRSADRLEETRLQILKAGVPAEKIN---- 61
Query: 361 SGSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHL 420
+ VAD + +V++T + KFG++DILVNNAG L +T+ N V L
Sbjct: 62 --AVVADVCE-ASGQDEVIRTTLAKFGKIDILVNNAGAL-------LTDGTSNTDQAVEL 111
Query: 421 F-STFALS-KAVWPIFLKQK------SGYIINTTS-TSGIYGNFGQCNYAAAKAAILGFS 471
+ TF L+ +AV + K K G I+N +S +G YA AKAA+ ++
Sbjct: 112 YQKTFKLNFQAVVEMTQKTKEYLIKTKGEIVNVSSIVAGPQAQPASPYYACAKAALDQYT 171
Query: 472 RTLALEGTKRGITVNVIAP 490
R A++ + G+ VN ++P
Sbjct: 172 RCTAIDLIQHGVRVNSVSP 190
Score = 69.7 bits (169), Expect = 2e-11
Identities = 49/188 (26%), Positives = 89/188 (47%), Gaps = 7/188 (3%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGD---AV 61
F + +IITG+ G+GR A+ +AK G +V + + +I K G + AV
Sbjct: 4 FSGKSIIITGSSSGIGRSAAVIFAKEGAQVTITGRSADRLEETRLQILKAGVPAEKINAV 63
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGIL--RDSSFAKMSEKQFQQVIDVHLNGA 119
+ ++ T ++ FG++DIL+NNAG L +S + + +Q+ ++
Sbjct: 64 VADVCEASGQDEVIRTTLAKFGKIDILVNNAGALLTDGTSNTDQAVELYQKTFKLNFQAV 123
Query: 120 FKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYN 178
++T+ ++ K K G I+N S AG Y+ AK L + A + ++
Sbjct: 124 VEMTQKTKEYLIKTK-GEIVNVSSIVAGPQAQPASPYYACAKAALDQYTRCTAIDLIQHG 182
Query: 179 INVNSIAP 186
+ VNS++P
Sbjct: 183 VRVNSVSP 190
>CE03951 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 73.6 bits (179), Expect = 1e-12
Identities = 52/191 (27%), Positives = 102/191 (53%), Gaps = 17/191 (8%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIV 372
GKV IITGS G+G++ A FA+ GAKV + + + +K+ + ++D++ ++
Sbjct: 7 GKVAIITGSSFGIGRATALLFAKEGAKVTVTGRSEERL---QGSKQALLDAGISDSNFLI 63
Query: 373 KEA--------QQVVQTAVDKFGRVDILVNNAGI----LRDRSFAKMTEDEWNAVINVHL 420
A ++ ++KFG+++ILVNNAG ++R+ D + V+ +++
Sbjct: 64 VPADITTSSGQDALISKTLEKFGQINILVNNAGASIADSQNRAGLDQGIDTYEKVLKLNV 123
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSGI-YGNFGQCNYAAAKAAILGFSRTLALEGT 479
S +++ + P K + G I+N +S + + + + Y AKAA+ ++R+ A++
Sbjct: 124 QSVIEMTQKIRPHLAKTR-GEIVNVSSVAALKFAHVRNPYYPLAKAALDQYTRSAAIDLI 182
Query: 480 KRGITVNVIAP 490
+GI VN + P
Sbjct: 183 SQGIRVNTVNP 193
Score = 72.8 bits (177), Expect = 2e-12
Identities = 54/194 (27%), Positives = 90/194 (45%), Gaps = 9/194 (4%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLG--GEG 58
M+ F +V IITG+ G+GR AL +AK G KV V Q + G
Sbjct: 1 MTGRFSGKVAIITGSSFGIGRATALLFAKEGAKVTVTGRSEERLQGSKQALLDAGISDSN 60
Query: 59 DAVANYDSVSDNGA-AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ----FQQVID 113
+ D + +G A++ + FG+++IL+NNAG S + Q +++V+
Sbjct: 61 FLIVPADITTSSGQDALISKTLEKFGQINILVNNAGASIADSQNRAGLDQGIDTYEKVLK 120
Query: 114 VHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGL-YGNFGQANYSAAKLGLLGFGESLAK 172
+++ ++T+ PH+ K + G I+N S A L + + Y AK L + S A
Sbjct: 121 LNVQSVIEMTQKIRPHLAKTR-GEIVNVSSVAALKFAHVRNPYYPLAKAALDQYTRSAAI 179
Query: 173 EGYKYNINVNSIAP 186
+ I VN++ P
Sbjct: 180 DLISQGIRVNTVNP 193
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/187 (29%), Positives = 92/187 (48%), Gaps = 9/187 (4%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVA---- 366
L GK ++ITG+ SG+GKS A A+ AKV + + V+EI K+ S V+
Sbjct: 4 LDGKTILITGASSGIGKSTAFEIAKV-AKVKLILAARRFSTVEEIAKELESKYEVSVLPL 62
Query: 367 --DTHDIVKEAQQVVQTAVDKFGRVDILVNNAGI-LRDRSFAKMTEDEWNAVINVHLFST 423
D D+ K V+++ +F +D+L+NNAG+ L + D+ +I ++
Sbjct: 63 KLDVSDL-KSIPGVIESLPKEFADIDVLINNAGLALGTDKVIDLNIDDAVTMITTNVLGM 121
Query: 424 FALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
A+++AV PIF + G I+N S +G G Y + K+A+ F+ L E I
Sbjct: 122 MAMTRAVLPIFYSKNKGDILNVGSIAGRESYVGGSVYCSTKSALAQFTSALRKETIDTRI 181
Query: 484 TVNVIAP 490
+ + P
Sbjct: 182 RIMEVDP 188
Score = 59.3 bits (142), Expect = 3e-08
Identities = 59/223 (26%), Positives = 98/223 (43%), Gaps = 15/223 (6%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGG-KVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDS 66
+ ++ITGA G+G+ A E AK K+++ S + + +E++ D
Sbjct: 7 KTILITGASSGIGKSTAFEIAKVAKVKLILAARRFSTVEEIAKELESKYEVSVLPLKLD- 65
Query: 67 VSDNGA--AIVETAISNFGRVDILINNAGI-LRDSSFAKMSEKQFQQVIDVHLNGAFKLT 123
VSD + ++E+ F +D+LINNAG+ L ++ +I ++ G +T
Sbjct: 66 VSDLKSIPGVIESLPKEFADIDVLINNAGLALGTDKVIDLNIDDAVTMITTNVLGMMAMT 125
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNS 183
RA P + G I+N S AG G + Y + K L F +L KE I +
Sbjct: 126 RAVLPIFYSKNKGDILNVGSIAGRESYVGGSVYCSTKSALAQFTSALRKETIDTRIRIME 185
Query: 184 IAP-LARSAMT------ENVIPANILKE---LGPEKIAPLILY 216
+ P L + + + N+ K L PE IA +IL+
Sbjct: 186 VDPGLVETEFSVVRFHGDKQKADNVYKNSEPLTPEDIAEVILF 228
>CE13008 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 247
Score = 72.4 bits (176), Expect = 3e-12
Identities = 65/195 (33%), Positives = 101/195 (51%), Gaps = 23/195 (11%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINK-----KYGSGSAVAD 367
GK VI+TGS SG+G++ A FA+YGA+V I RD + K K V
Sbjct: 6 GKSVIVTGSSSGIGRATAVLFAKYGAQVTITG-RDAGKLEATKKKMLKVMKNPENVCVVV 64
Query: 368 THDIVKEAQ-QVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF-STFA 425
+ + Q ++VQ+A+D FGR+D+LVNNAG A + + +N + L+ TF
Sbjct: 65 ANLTDSDGQDEIVQSALDAFGRIDVLVNNAG-------ANVVDGTFNTDQSTELYHKTFQ 117
Query: 426 LS-KAVWPIFLKQKS------GYIINTTS-TSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
++ +AV + K K+ G I+N +S +G YAA+KAA+ ++R +AL+
Sbjct: 118 INFEAVIEMVKKTKNHLIESKGEIVNVSSVAAGPQALAPSPYYAASKAALDQYTRCVALD 177
Query: 478 GTKRGITVNVIAPHA 492
+GI N + A
Sbjct: 178 LILQGIEENFTSNRA 192
Score = 68.9 bits (167), Expect = 3e-11
Identities = 60/220 (27%), Positives = 104/220 (47%), Gaps = 18/220 (8%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGD----A 60
F + VI+TG+ G+GR A+ +AK G +V + ++ +++ K+ +
Sbjct: 4 FSGKSVIVTGSSSGIGRATAVLFAKYGAQVTITGRDAGKLEATKKKMLKVMKNPENVCVV 63
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGI-LRDSSF-AKMSEKQFQQVIDVHLNG 118
VAN SD IV++A+ FGR+D+L+NNAG + D +F S + + + ++
Sbjct: 64 VANLTD-SDGQDEIVQSALDAFGRIDVLVNNAGANVVDGTFNTDQSTELYHKTFQINFEA 122
Query: 119 AFKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
++ + H+ + K G I+N S AG Y+A+K L + +A +
Sbjct: 123 VIEMVKKTKNHLIESK-GEIVNVSSVAAGPQALAPSPYYAASKAALDQYTRCVALDLILQ 181
Query: 178 NINVNSIAPLARSAMTENVIPANILKELGPEKIAPLILYL 217
I N + A IPA + + PE IA LI++L
Sbjct: 182 GIEENFTSNRA-------CIPAGVCGK--PEDIAELIIFL 212
>CE03954 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 274
Score = 72.4 bits (176), Expect = 3e-12
Identities = 54/188 (28%), Positives = 97/188 (50%), Gaps = 13/188 (6%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIVK 373
KV IITGS +G+G++ A A GAKV I RD + + + +G + + + +V
Sbjct: 7 KVAIITGSSNGIGRATAVLLATDGAKVTITG-RDAARLEETRQAILKAGISATNVNSVVA 65
Query: 374 EA------QQVVQTAVDKFGRVDILVNNAGI----LRDRSFAKMTEDEWNAVINVHLFST 423
+ ++ + +DKFG+++IL+NNAG + ++ K + + + ++L S
Sbjct: 66 DVTTAEGQDLLISSTLDKFGKINILINNAGANIPDSQGQTRTKCSIENLTKMFQLNLQSV 125
Query: 424 FALSKAVWPIFLKQKSGYIINTTST-SGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
+ + V P K + G I+N +S +G Y++AKAA+ +SR A++ G
Sbjct: 126 VEMVQKVRPHLAKTR-GEIVNISSIGAGPAAQPASPYYSSAKAALDQYSRCAAIDLISEG 184
Query: 483 ITVNVIAP 490
I +NV+ P
Sbjct: 185 IRINVVQP 192
Score = 68.2 bits (165), Expect = 5e-11
Identities = 52/190 (27%), Positives = 89/190 (46%), Gaps = 9/190 (4%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEG---DAV 61
F D+V IITG+ G+GR A+ A G KV + + + Q I K G ++V
Sbjct: 4 FTDKVAIITGSSNGIGRATAVLLATDGAKVTITGRDAARLEETRQAILKAGISATNVNSV 63
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGI-LRDS---SFAKMSEKQFQQVIDVHLN 117
+ ++ ++ + + FG+++ILINNAG + DS + K S + ++ ++L
Sbjct: 64 VADVTTAEGQDLLISSTLDKFGKINILINNAGANIPDSQGQTRTKCSIENLTKMFQLNLQ 123
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGESLAKEGYK 176
++ + PH+ K + G I+N S AG YS+AK L + A +
Sbjct: 124 SVVEMVQKVRPHLAKTR-GEIVNISSIGAGPAAQPASPYYSSAKAALDQYSRCAAIDLIS 182
Query: 177 YNINVNSIAP 186
I +N + P
Sbjct: 183 EGIRINVVQP 192
>CE03132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 71.6 bits (174), Expect = 5e-12
Identities = 60/198 (30%), Positives = 94/198 (47%), Gaps = 17/198 (8%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKK-LGGEGD 59
M F +V IITG+ G+GR AL +AK G KV V GRS + ++E KK L G
Sbjct: 1 MPKRFSKKVAIITGSSSGIGRETALLFAKEGAKVTVT--GRS--EEKLEETKKALLDAGI 56
Query: 60 AVANYDSV------SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ----FQ 109
+N+ V S ++ + FGR++IL+NNAG + + Q ++
Sbjct: 57 KESNFLIVPADITFSTGQDELISQTLKKFGRINILVNNAGASIPDAKKRTGIDQGIETYE 116
Query: 110 QVIDVHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQA-NYSAAKLGLLGFGE 168
QV+ +++ ++T+ PH+ K + G I+N S L + + Y AK L +
Sbjct: 117 QVMKLNVQSVIEMTQKVRPHLAKSR-GEIVNVSSVVALKAGWTRTPYYPLAKAALDQYTR 175
Query: 169 SLAKEGYKYNINVNSIAP 186
S A I VN++ P
Sbjct: 176 SAAIALISEGIRVNTVNP 193
Score = 71.6 bits (174), Expect = 5e-12
Identities = 55/195 (28%), Positives = 96/195 (49%), Gaps = 17/195 (8%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
K KV IITGS SG+G+ A FA+ GAKV + + E KK + + ++
Sbjct: 3 KRFSKKVAIITGSSSGIGRETALLFAKEGAKVTVTGRSEEKL---EETKKALLDAGIKES 59
Query: 369 HDIVKEA--------QQVVQTAVDKFGRVDILVNNAGI----LRDRSFAKMTEDEWNAVI 416
+ ++ A +++ + KFGR++ILVNNAG + R+ + + V+
Sbjct: 60 NFLIVPADITFSTGQDELISQTLKKFGRINILVNNAGASIPDAKKRTGIDQGIETYEQVM 119
Query: 417 NVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQC-NYAAAKAAILGFSRTLA 475
+++ S +++ V P K + G I+N +S + + + Y AKAA+ ++R+ A
Sbjct: 120 KLNVQSVIEMTQKVRPHLAKSR-GEIVNVSSVVALKAGWTRTPYYPLAKAALDQYTRSAA 178
Query: 476 LEGTKRGITVNVIAP 490
+ GI VN + P
Sbjct: 179 IALISEGIRVNTVNP 193
>At2g29370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 71.6 bits (174), Expect = 5e-12
Identities = 58/205 (28%), Positives = 92/205 (44%), Gaps = 6/205 (2%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVA 366
P SL G ++TG GLGK+ + A GA+V RD + + + + + G V
Sbjct: 12 PKWSLEGMTALVTGGSKGLGKAVVEELAMLGARVH-TCARDETQLQESLREWQAKGLQVT 70
Query: 367 DTHDIVKEAQQ---VVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFS 422
+ V Q +++T F G++ ILV N GI + + T +E++ +I +L S
Sbjct: 71 TSVCDVSSRDQREKLMETVSSLFQGKLSILVPNVGIGVLKPTTECTAEEFSFIIATNLES 130
Query: 423 TFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
TF S+ P+ SG I+ +S +G+ Y A K A+ +R LA E
Sbjct: 131 TFHFSQLAHPLLKASGSGNIVLMSSVAGVVNLGNTSIYGATKGAMNQLARNLACEWASDN 190
Query: 483 ITVNVIAP-HAETAMTKTIFSSKEL 506
I N + P T TK K++
Sbjct: 191 IRANSVCPWFITTPSTKDFLGDKDV 215
Score = 55.5 bits (132), Expect = 4e-07
Identities = 45/177 (25%), Positives = 75/177 (41%), Gaps = 1/177 (0%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TG GLG+ E A G +V + ++E + G + S D
Sbjct: 22 LVTGGSKGLGKAVVEELAMLGARVHTCARDETQLQESLREWQAKGLQVTTSVCDVSSRDQ 81
Query: 71 GAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
++ET S F G++ IL+ N GI + + ++F +I +L F ++ A P
Sbjct: 82 REKLMETVSSLFQGKLSILVPNVGIGVLKPTTECTAEEFSFIIATNLESTFHFSQLAHPL 141
Query: 130 MRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
++ G I+ S AG+ + Y A K + +LA E NI NS+ P
Sbjct: 142 LKASGSGNIVLMSSVAGVVNLGNTSIYGATKGAMNQLARNLACEWASDNIRANSVCP 198
>At1g10310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 242
Score = 71.6 bits (174), Expect = 5e-12
Identities = 53/167 (31%), Positives = 81/167 (47%), Gaps = 2/167 (1%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
R V+ITG GLGR ALE AKRG V+ + ++ E+ A+ S
Sbjct: 18 RTVLITGVSKGLGRALALELAKRGHTVIGCARSQEKLTALQSELSSSTNHLLLTADVKSN 77
Query: 68 SDNGAAIVETAISNFGRVDILINNAGIL-RDSSFAKMSEKQFQQVIDVHLNGAFKLTRAA 126
S + + T + G DI++NNAG + ++S ++S + F V+D ++ G + R
Sbjct: 78 S-SVEEMAHTIVEKKGVPDIIVNNAGTINKNSKIWEVSAEDFDNVMDTNVKGVANVLRHF 136
Query: 127 WPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
P M +K G I+N S G G A Y A+K + G ++AKE
Sbjct: 137 IPLMLPRKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKE 183
Score = 60.8 bits (146), Expect = 9e-09
Identities = 51/180 (28%), Positives = 90/180 (49%), Gaps = 5/180 (2%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIVK 373
+ V+ITG GLG++ A A+ G VI R + ++ S + + T D+
Sbjct: 18 RTVLITGVSKGLGRALALELAKRG-HTVIGCARSQEKLTALQSELSSSTNHLLLTADVKS 76
Query: 374 EA--QQVVQTAVDKFGRVDILVNNAGILRDRS-FAKMTEDEWNAVINVHLFSTFALSKAV 430
+ +++ T V+K G DI+VNNAG + S +++ ++++ V++ ++ + +
Sbjct: 77 NSSVEEMAHTIVEKKGVPDIIVNNAGTINKNSKIWEVSAEDFDNVMDTNVKGVANVLRHF 136
Query: 431 WPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVIAP 490
P+ L +K G I+N +S G G Y A+K AI G SR +A E G+ V + P
Sbjct: 137 IPLMLPRKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKE-VVEGMAVVALNP 195
>YNL202w [R] KOG0725 Reductases with broad range of substrate specificities
Length = 295
Score = 71.2 bits (173), Expect = 6e-12
Identities = 67/237 (28%), Positives = 100/237 (41%), Gaps = 8/237 (3%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANY 64
FK +V +TG G + RV G K + + + + I +L + DAV
Sbjct: 25 FKGKVAFVTGGAGTICRVQTEALVLLGCKAAIVGRDQERTEQAAKGISQLAKDKDAVLAI 84
Query: 65 DSVSDNGAAIVETAISN----FGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
+V VE A+ FG++D +I A FA +S F+ V+D+ L G+F
Sbjct: 85 ANVDVRNFEQVENAVKKTVEKFGKIDFVIAGAAGNFVCDFANLSPNAFKSVVDIDLLGSF 144
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
+A ++K K G I+ + YG Q + AAK G+ ++LA E I
Sbjct: 145 NTAKACLKELKKSK-GSILFVSATFHYYGVPFQGHVGAAKAGIDALAKNLAVELGPLGIR 203
Query: 181 VNSIAPLARSAMTENV--IPANILKELGPEKIAPLILYLTHENTKVTNNIFELAAGF 235
N IAP A TE + + KE KI L T + + T IF AA +
Sbjct: 204 SNCIAPGAID-NTEGLKRLAGKKYKEKALAKIPLQRLGSTRDIAESTVYIFSPAASY 259
Score = 61.6 bits (148), Expect = 5e-09
Identities = 51/188 (27%), Positives = 91/188 (48%), Gaps = 9/188 (4%)
Query: 312 RGKVVIITGSGSGLGKSHAQWFARYGAKVVI---NDIRDPSAV--VDEINKKYGSGSAVA 366
+GKV +TG + + + G K I + R A + ++ K + A+A
Sbjct: 26 KGKVAFVTGGAGTICRVQTEALVLLGCKAAIVGRDQERTEQAAKGISQLAKDKDAVLAIA 85
Query: 367 DTHDI--VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTF 424
+ D+ ++ + V+ V+KFG++D ++ A FA ++ + + +V+++ L +F
Sbjct: 86 NV-DVRNFEQVENAVKKTVEKFGKIDFVIAGAAGNFVCDFANLSPNAFKSVVDIDLLGSF 144
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
+KA LK+ G I+ ++T YG Q + AAKA I ++ LA+E GI
Sbjct: 145 NTAKACLKE-LKKSKGSILFVSATFHYYGVPFQGHVGAAKAGIDALAKNLAVELGPLGIR 203
Query: 485 VNVIAPHA 492
N IAP A
Sbjct: 204 SNCIAPGA 211
>SPAC977.08 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 71.2 bits (173), Expect = 6e-12
Identities = 40/112 (35%), Positives = 57/112 (50%)
Query: 379 VQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKAVWPIFLKQK 438
V+ A+ FGR+D+L+NNAG TE++ + + N ++F + KA+ PIF Q
Sbjct: 33 VEKAISHFGRIDVLLNNAGYSVYSPLESTTEEQIHNIFNTNVFGALEVIKAITPIFRSQH 92
Query: 439 SGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVIAP 490
+G IIN +S G C Y K AI G S L E G+ V +I P
Sbjct: 93 NGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIGVKVKIIEP 144
Score = 63.2 bits (152), Expect = 2e-09
Identities = 41/126 (32%), Positives = 60/126 (47%), Gaps = 4/126 (3%)
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
V N+ S+ + VE AIS+FGR+D+L+NNAG S +E+Q + + ++ GA
Sbjct: 23 VNNFSSIKKS----VEKAISHFGRIDVLLNNAGYSVYSPLESTTEEQIHNIFNTNVFGAL 78
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
++ +A P R Q G IIN S G Y K + G E+L E +
Sbjct: 79 EVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIGVK 138
Query: 181 VNSIAP 186
V I P
Sbjct: 139 VKIIEP 144
>SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 71.2 bits (173), Expect = 6e-12
Identities = 40/112 (35%), Positives = 57/112 (50%)
Query: 379 VQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKAVWPIFLKQK 438
V+ A+ FGR+D+L+NNAG TE++ + + N ++F + KA+ PIF Q
Sbjct: 33 VEKAISHFGRIDVLLNNAGYSVYSPLESTTEEQIHNIFNTNVFGALEVIKAITPIFRSQH 92
Query: 439 SGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVIAP 490
+G IIN +S G C Y K AI G S L E G+ V +I P
Sbjct: 93 NGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIGVKVKIIEP 144
Score = 63.2 bits (152), Expect = 2e-09
Identities = 41/126 (32%), Positives = 60/126 (47%), Gaps = 4/126 (3%)
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
V N+ S+ + VE AIS+FGR+D+L+NNAG S +E+Q + + ++ GA
Sbjct: 23 VNNFSSIKKS----VEKAISHFGRIDVLLNNAGYSVYSPLESTTEEQIHNIFNTNVFGAL 78
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
++ +A P R Q G IIN S G Y K + G E+L E +
Sbjct: 79 EVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIGVK 138
Query: 181 VNSIAP 186
V I P
Sbjct: 139 VKIIEP 144
>At5g18210 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 71.2 bits (173), Expect = 6e-12
Identities = 78/250 (31%), Positives = 110/250 (43%), Gaps = 18/250 (7%)
Query: 308 IKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVIN---DIRDPSAVVDEINKKYGS--- 361
+ SL G+V I+TGS G+G++ A A GAK+VIN + V EIN G+
Sbjct: 5 VSSLAGRVAIVTGSSRGIGRAIAIHLAELGAKIVINYTTRSTEADQVAAEINSSAGTVPQ 64
Query: 362 GSAVADTHDIVKEAQ--QVVQTAVDKFGR-VDILVNNAGILRDR--SFAKMTEDEWNAVI 416
AV DI + +Q + A F V ILVN+AGIL + A +E++ +
Sbjct: 65 PIAVVFLADISEPSQIKSLFDAAEKAFNSPVHILVNSAGILNPNYPTIANTPIEEFDRIF 124
Query: 417 NVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLAL 476
V+ +F K + G II TS+ GQ Y A+KAA+ + LA
Sbjct: 125 KVNTRGSFLCCKEAAKRLKRGGGGRIILLTSSLTEALIPGQGAYTASKAAVEAMVKILAK 184
Query: 477 EGTKRGITVNVIAPHAETAMTKTIFSSKELNNHFDPGFVSPFVVLLCSDELQELGKNRVK 536
E GIT N ++P T+ F K + SPF L E +++ V
Sbjct: 185 ELKGLGITANCVSP--GPVATEMFFDGKSEETVMNIIERSPFGRL---GETKDIAS--VV 237
Query: 537 GLLFEVGGGW 546
G L GG W
Sbjct: 238 GFLASDGGEW 247
Score = 69.3 bits (168), Expect = 2e-11
Identities = 58/188 (30%), Positives = 91/188 (47%), Gaps = 9/188 (4%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSA-ADSVVQEIKKLGG---EGDAVAN 63
RV I+TG+ G+GR A+ A+ G K+V+N RS AD V EI G + AV
Sbjct: 11 RVAIVTGSSRGIGRAIAIHLAELGAKIVINYTTRSTEADQVAAEINSSAGTVPQPIAVVF 70
Query: 64 YDSVSDNG--AAIVETAISNFGR-VDILINNAGILRDS--SFAKMSEKQFQQVIDVHLNG 118
+S+ ++ + A F V IL+N+AGIL + + A ++F ++ V+ G
Sbjct: 71 LADISEPSQIKSLFDAAEKAFNSPVHILVNSAGILNPNYPTIANTPIEEFDRIFKVNTRG 130
Query: 119 AFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYN 178
+F + A +++ GRII S GQ Y+A+K + + LAKE
Sbjct: 131 SFLCCKEAAKRLKRGGGGRIILLTSSLTEALIPGQGAYTASKAAVEAMVKILAKELKGLG 190
Query: 179 INVNSIAP 186
I N ++P
Sbjct: 191 ITANCVSP 198
>At4g10020 [Q] KOG1205 Predicted dehydrogenase
Length = 389
Score = 70.5 bits (171), Expect = 1e-11
Identities = 52/170 (30%), Positives = 83/170 (48%), Gaps = 3/170 (1%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
+D+VV+ITGA +G A EYAKRG +V+ V + K++G + D
Sbjct: 48 EDKVVVITGASSAIGEQIAYEYAKRGANLVLVARREQRLRVVSNKAKQIGANHVIIIAAD 107
Query: 66 SV-SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ-FQQVIDVHLNGAFKLT 123
+ D+ + A++ +GRVD L+N A + F ++S+ F ++D++ G T
Sbjct: 108 VIKEDDCRRFITQAVNYYGRVDHLVNTASLGHTFYFEEVSDTTVFPHLLDINFWGNVYPT 167
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
A P++ Q GRI+ S + YSAAK L+ F E+L E
Sbjct: 168 YVALPYLH-QTNGRIVVNASVENWLPLPRMSLYSAAKAALVNFYETLRFE 216
Score = 64.3 bits (155), Expect = 8e-10
Identities = 49/179 (27%), Positives = 90/179 (49%), Gaps = 5/179 (2%)
Query: 303 NGPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPS-AVVDEINKKYGS 361
N +++ KVV+ITG+ S +G+ A +A+ GA +V+ R+ VV K+ G+
Sbjct: 39 NSYFATENMEDKVVVITGASSAIGEQIAYEYAKRGANLVLVARREQRLRVVSNKAKQIGA 98
Query: 362 GSAVADTHDIVKE--AQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDE-WNAVINV 418
+ D++KE ++ + AV+ +GRVD LVN A + F ++++ + ++++
Sbjct: 99 NHVIIIAADVIKEDDCRRFITQAVNYYGRVDHLVNTASLGHTFYFEEVSDTTVFPHLLDI 158
Query: 419 HLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
+ + + P +L Q +G I+ S Y+AAKAA++ F TL E
Sbjct: 159 NFWGNVYPTYVALP-YLHQTNGRIVVNASVENWLPLPRMSLYSAAKAALVNFYETLRFE 216
>7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 242
Score = 70.5 bits (171), Expect = 1e-11
Identities = 52/181 (28%), Positives = 95/181 (51%), Gaps = 9/181 (4%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHD 370
L GKV+++TG+G+G+G++ + A GA VI R P +++ +
Sbjct: 5 LAGKVILVTGAGAGIGQALVKQLASAGA-TVIAVARKP----EQLQQLVAFDPVHIQPLQ 59
Query: 371 IVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKAV 430
+ Q V+ + K +D LVNNAG+ + F ++TE +++ +V++ + F +++++
Sbjct: 60 LDLSGWQAVREGLAKVPLLDGLVNNAGVAIIKPFEELTEQDFDTHFDVNIKAVFNVTQSL 119
Query: 431 WPIFLKQKSG-YIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVIA 489
P + K G I+N +S + G Y+A KAA+ +++LALE R I VN +
Sbjct: 120 LP---RLKDGASIVNVSSIASSRSFGGHTAYSATKAALDSLTKSLALELGPRKIRVNSVN 176
Query: 490 P 490
P
Sbjct: 177 P 177
Score = 65.5 bits (158), Expect = 4e-10
Identities = 48/186 (25%), Positives = 83/186 (43%), Gaps = 9/186 (4%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA 60
M + +V+++TGAG G+G+ + A G V+ A +++++L
Sbjct: 1 MWTDLAGKVILVTGAGAGIGQALVKQLASAGATVI-------AVARKPEQLQQLVAFDPV 53
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
+ +G V ++ +D L+NNAG+ F +++E+ F DV++ F
Sbjct: 54 HIQPLQLDLSGWQAVREGLAKVPLLDGLVNNAGVAIIKPFEELTEQDFDTHFDVNIKAVF 113
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
+T++ P ++ I+N S A G YSA K L +SLA E I
Sbjct: 114 NVTQSLLPRLKDG--ASIVNVSSIASSRSFGGHTAYSATKAALDSLTKSLALELGPRKIR 171
Query: 181 VNSIAP 186
VNS+ P
Sbjct: 172 VNSVNP 177
>7301617_1 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 302
Score = 69.7 bits (169), Expect = 2e-11
Identities = 51/190 (26%), Positives = 90/190 (46%), Gaps = 13/190 (6%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAAD---------SVVQEIKKLGGEG 58
R + ITGA G+G+ AL+ A+ G +VV ++A S +EI+K GG+
Sbjct: 10 RTLFITGASRGIGKEIALKAARDGANIVV--AAKTAEPHPKLPGTIYSAAEEIEKAGGKA 67
Query: 59 DAVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNG 118
+ VE A++ FG +DI+INNA + ++ K++ + +++ G
Sbjct: 68 YPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAISLTNTPDTDMKRYDLMHNINTRG 127
Query: 119 AFKLTRAAWPHMRKQKFGRIINTCSPAGLYGN-FG-QANYSAAKLGLLGFGESLAKEGYK 176
F +++ P+++K I+N P + FG Y+ AK G+ +A E
Sbjct: 128 TFLVSKVCLPYLKKSNHAHILNISPPLSMKPKWFGPHVAYTMAKYGMSMCVLGMAAEFKD 187
Query: 177 YNINVNSIAP 186
I+VN++ P
Sbjct: 188 EGISVNALWP 197
Score = 63.5 bits (153), Expect = 1e-09
Identities = 54/192 (28%), Positives = 86/192 (44%), Gaps = 13/192 (6%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVIN-DIRDPS--------AVVDEINKKYGS 361
L G+ + ITG+ G+GK A AR GA +V+ +P + +EI K G
Sbjct: 7 LAGRTLFITGASRGIGKEIALKAARDGANIVVAAKTAEPHPKLPGTIYSAAEEIEKAGGK 66
Query: 362 G-SAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHL 420
V D D ++ + V+ AV KFG +DI++NNA + + ++ + N++
Sbjct: 67 AYPCVVDVRD-EQQVRSAVEAAVAKFGGIDIVINNASAISLTNTPDTDMKRYDLMHNINT 125
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGN-FG-QCNYAAAKAAILGFSRTLALEG 478
TF +SK P K +I+N + + FG Y AK + +A E
Sbjct: 126 RGTFLVSKVCLPYLKKSNHAHILNISPPLSMKPKWFGPHVAYTMAKYGMSMCVLGMAAEF 185
Query: 479 TKRGITVNVIAP 490
GI+VN + P
Sbjct: 186 KDEGISVNALWP 197
>At2g29350 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 69.3 bits (168), Expect = 2e-11
Identities = 62/229 (27%), Positives = 102/229 (44%), Gaps = 17/229 (7%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTH 369
SL G ++TG G+G++ + A GAKV RD + + + + + G V +
Sbjct: 14 SLGGMTALVTGGSKGIGEAVVEELAMLGAKVH-TCARDETQLQERLREWQAKGFQVTTSV 72
Query: 370 -DIVKEAQQV--VQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
D+ Q+V ++T + G+++ILVNN G + + T ++++ V+ +L S F
Sbjct: 73 CDVSSRDQRVKLMETVSSLYQGKLNILVNNVGTSIFKPTTEYTAEDFSFVMATNLESAFH 132
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSG-IYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
LS+ P+ SG I+ +S +G ++ N G Y A K A+ +R LA E I
Sbjct: 133 LSQLAHPLLKASGSGSIVLISSAAGVVHVNVGSI-YGATKGAMNQLARNLACEWASDNIR 191
Query: 485 VNVIAPHAETAMTKTIFSSKELNNHF----------DPGFVSPFVVLLC 523
N + P T F +E + VSP V LC
Sbjct: 192 TNSVCPWYITTPLSNDFFDEEFKKEAVRTTPMGRVGEANEVSPLVAFLC 240
Score = 56.6 bits (135), Expect = 2e-07
Identities = 48/178 (26%), Positives = 78/178 (42%), Gaps = 3/178 (1%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TG G+G E A G KV + ++E + G + S D
Sbjct: 21 LVTGGSKGIGEAVVEELAMLGAKVHTCARDETQLQERLREWQAKGFQVTTSVCDVSSRDQ 80
Query: 71 GAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
++ET S + G+++IL+NN G + + + F V+ +L AF L++ A P
Sbjct: 81 RVKLMETVSSLYQGKLNILVNNVGTSIFKPTTEYTAEDFSFVMATNLESAFHLSQLAHPL 140
Query: 130 MRKQKFGRIINTCSPAG-LYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
++ G I+ S AG ++ N G Y A K + +LA E NI NS+ P
Sbjct: 141 LKASGSGSIVLISSAAGVVHVNVGSI-YGATKGAMNQLARNLACEWASDNIRTNSVCP 197
>CE10908 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 313
Score = 68.9 bits (167), Expect = 3e-11
Identities = 61/202 (30%), Positives = 96/202 (47%), Gaps = 15/202 (7%)
Query: 299 PENKNGPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVIN----DIRDPSAVVDE 354
P K+ +P SL GKV ++TG G+GLGK+ A FA GA V I D+ + +A DE
Sbjct: 12 PVVKSVALPPGSLNGKVALVTGGGTGLGKAIATTFAHLGASVAIAARRLDVLEKTA--DE 69
Query: 355 INKKYGS--GSAVADTHDIVKEAQQVVQTAVDKFGRV-DILVNNAGILRDRSFAKMTEDE 411
I G D D K A + K G DIL+NNA + +++ +
Sbjct: 70 IRSSTGGVCEPFQMDVKDPAKVA-KAFDAVEKKLGHTPDILINNAAGNFIMATERLSPNA 128
Query: 412 WNAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQ---CNYAAAKAAIL 468
+ +I++ L T ++ + ++QK G + + +T +Y G A +KA +
Sbjct: 129 YGTIIDIVLKGTLHVTTELGRRCIQQKRGASVLSITT--LYAQSGAPFVVPSAVSKAGVE 186
Query: 469 GFSRTLALEGTKRGITVNVIAP 490
+++LA E K G+ N IAP
Sbjct: 187 NMTKSLASEWAKHGLRFNAIAP 208
Score = 52.4 bits (124), Expect = 3e-06
Identities = 50/185 (27%), Positives = 75/185 (40%), Gaps = 9/185 (4%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+V ++TG G GLG+ A +A G V + + EI+ G G V
Sbjct: 27 KVALVTGGGTGLGKAIATTFAHLGASVAIAARRLDVLEKTADEIRSSTG-GVCEPFQMDV 85
Query: 68 SDNG--AAIVETAISNFGRV-DILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTR 124
D A + G DILINNA + ++S + +ID+ L G +T
Sbjct: 86 KDPAKVAKAFDAVEKKLGHTPDILINNAAGNFIMATERLSPNAYGTIIDIVLKGTLHVTT 145
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQ---ANYSAAKLGLLGFGESLAKEGYKYNINV 181
+QK G + S LY G + +K G+ +SLA E K+ +
Sbjct: 146 ELGRRCIQQKRG--ASVLSITTLYAQSGAPFVVPSAVSKAGVENMTKSLASEWAKHGLRF 203
Query: 182 NSIAP 186
N+IAP
Sbjct: 204 NAIAP 208
>At2g29360 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 271
Score = 68.6 bits (166), Expect = 4e-11
Identities = 54/212 (25%), Positives = 94/212 (43%), Gaps = 10/212 (4%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVA 366
P SL G ++TG G+G++ + A GA++ RD + + + + K G V
Sbjct: 12 PRWSLVGMTALVTGGSKGIGEAVVEELATLGARIH-TCARDETQLQESLRKWQAKGFQVT 70
Query: 367 ------DTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHL 420
+ D ++ + V T + G+++ILVNN G + + T ++++ + +L
Sbjct: 71 TSVCDVSSRDKREKLMETVSTIFE--GKLNILVNNVGTCIVKPTLQHTAEDFSFTMATNL 128
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTK 480
S F LS+ P+ SG I+ +S SG+ G Y +K A+ R LA E
Sbjct: 129 ESAFHLSQLAHPLLKASGSGSIVLISSVSGVVHVNGASIYGVSKGAMNQLGRNLACEWAS 188
Query: 481 RGITVNVIAP-HAETAMTKTIFSSKELNNHFD 511
I N + P ET + S++E +
Sbjct: 189 DNIRTNSVCPWFIETPLVTESLSNEEFRKEVE 220
Score = 55.5 bits (132), Expect = 4e-07
Identities = 46/198 (23%), Positives = 86/198 (43%), Gaps = 3/198 (1%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TG G+G E A G ++ + +++ + G + S D
Sbjct: 22 LVTGGSKGIGEAVVEELATLGARIHTCARDETQLQESLRKWQAKGFQVTTSVCDVSSRDK 81
Query: 71 GAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
++ET + F G+++IL+NN G + + + F + +L AF L++ A P
Sbjct: 82 REKLMETVSTIFEGKLNILVNNVGTCIVKPTLQHTAEDFSFTMATNLESAFHLSQLAHPL 141
Query: 130 MRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP--L 187
++ G I+ S +G+ G + Y +K + G +LA E NI NS+ P +
Sbjct: 142 LKASGSGSIVLISSVSGVVHVNGASIYGVSKGAMNQLGRNLACEWASDNIRTNSVCPWFI 201
Query: 188 ARSAMTENVIPANILKEL 205
+TE++ KE+
Sbjct: 202 ETPLVTESLSNEEFRKEV 219
>At1g07450 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 68.6 bits (166), Expect = 4e-11
Identities = 56/229 (24%), Positives = 106/229 (45%), Gaps = 17/229 (7%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTH 369
SL+G ++TG G+G + + +GA+V I DI D + + + ++ + G V+ +
Sbjct: 7 SLQGMTALVTGGSKGIGYAIVEELVGFGARVHICDI-DETLLNECLSGWHAKGFEVSGSI 65
Query: 370 -DIVKEAQ--QVVQTAVDKFG-RVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
D+ Q Q++QT FG +++IL+NN G + + T +++++++ +L S +
Sbjct: 66 CDVSSRPQRVQLMQTVSSLFGAKLNILINNVGKYILKPTLESTAEDFSSLMATNLESAYY 125
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
+S+ P+ +G I+ +S +G+ Y K A+ +R LA E I
Sbjct: 126 ISQLAHPLLKASGNGNIVFISSVTGVVSGTSTI-YGVTKGALNQLARDLACEWASDNIRA 184
Query: 486 NVIAPHA-----------ETAMTKTIFSSKELNNHFDPGFVSPFVVLLC 523
N +AP + + +FS L +P V+ V LC
Sbjct: 185 NSVAPWVTATSLVQKYLEDEIFAEAMFSRTPLGRACEPREVASLVTFLC 233
>7296047 [Q] KOG1205 Predicted dehydrogenase
Length = 321
Score = 68.2 bits (165), Expect = 5e-11
Identities = 54/197 (27%), Positives = 104/197 (52%), Gaps = 16/197 (8%)
Query: 306 IPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKK-YGSGSA 364
+ + S+RG+VV ITG+ SG+G++ A AR+G K+V++ R ++++ ++ +
Sbjct: 39 VSLSSMRGQVVWITGASSGIGRALALSLARHGVKLVLSARR--LEQLEQVQEECLAAARG 96
Query: 365 VADTHDI---------VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAV 415
+ T D+ + E + + T ++ F R+D+LVNNAG + S+ ++ + +
Sbjct: 97 LLATKDVLVIQMDMLDLDEHKTHLNTVLNHFHRLDVLVNNAGRSQRASWTEVEIEVDREL 156
Query: 416 INVHLFSTFALSKAVWPIFLKQKS--GYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRT 473
+ +F+ LS+ V F++Q G+I T+S +G Y AAK A+ + +
Sbjct: 157 FELDVFAVVHLSRLVVRYFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLS 216
Query: 474 LALEGTKRGITVNVIAP 490
L +E R + V++ AP
Sbjct: 217 LKVE--MRKLDVSLFAP 231
Score = 60.8 bits (146), Expect = 9e-09
Identities = 53/197 (26%), Positives = 94/197 (46%), Gaps = 8/197 (4%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKK-----LGGEGDA 60
+ +VV ITGA G+GR AL A+ G K+V++ + V +E L +
Sbjct: 45 RGQVVWITGASSGIGRALALSLARHGVKLVLSARRLEQLEQVQEECLAAARGLLATKDVL 104
Query: 61 VANYDSVS-DNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGA 119
V D + D + T +++F R+D+L+NNAG + +S+ ++ + +++ ++ +
Sbjct: 105 VIQMDMLDLDEHKTHLNTVLNHFHRLDVLVNNAGRSQRASWTEVEIEVDRELFELDVFAV 164
Query: 120 FKLTRAAWPHMRKQKFGR--IINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
L+R + +Q GR I T S AG Y AAK L + SL E K
Sbjct: 165 VHLSRLVVRYFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVEMRKL 224
Query: 178 NINVNSIAPLARSAMTE 194
++++ + P+A + E
Sbjct: 225 DVSLFAPGPIATDFLQE 241
>YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 308
Score = 67.8 bits (164), Expect = 7e-11
Identities = 63/252 (25%), Positives = 112/252 (44%), Gaps = 17/252 (6%)
Query: 2 SLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAV 61
S+ K+ +ITG GLG A E ++R KV+V D+ + V+ + D +
Sbjct: 33 SILSKNATALITGGSSGLGFELAKELSRRINKVIVADIQSFPTFAQVEYNNIFYYQCD-I 91
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFK 121
+ D + + AI + G ++I+INNAG+ M+ K+ +Q+ID++L GA++
Sbjct: 92 TSLDEIKNLKKAIER----DHGNINIIINNAGVAHIKKLEHMTNKEVEQLIDINLIGAYR 147
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGE-------SLAKEG 174
+ M + G IIN S G +Y A+K ++GF + SL+ E
Sbjct: 148 IISTFAEDMIDNREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLSTEC 207
Query: 175 YKYNINVNSIAP--LARSAMTENVIPANIL-KELGPEKIAPLILYLTHENTKVTNN--IF 229
K I + P + + + P+ +L ++ P ++A I+ N T N +
Sbjct: 208 NKTGIKTLLVCPGKIKTNMFIDVPTPSKLLAPDIIPSQLALAIISAMEHNHLQTLNAPYY 267
Query: 230 ELAAGFYSQIRW 241
F+ + W
Sbjct: 268 VNLVPFFKTLSW 279
Score = 67.0 bits (162), Expect = 1e-10
Identities = 48/187 (25%), Positives = 86/187 (45%), Gaps = 12/187 (6%)
Query: 312 RGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRD-PSAVVDEINKKYGSGSAVADTHD 370
+ +ITG SGLG A+ +R KV++ DI+ P+ E N + + D
Sbjct: 37 KNATALITGGSSGLGFELAKELSRRINKVIVADIQSFPTFAQVEYNNIFYYQCDITSL-D 95
Query: 371 IVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKAV 430
+K ++ ++ G ++I++NNAG+ + MT E +I+++L + +
Sbjct: 96 EIKNLKKAIER---DHGNINIIINNAGVAHIKKLEHMTNKEVEQLIDINLIGAYRIISTF 152
Query: 431 WPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFS-------RTLALEGTKRGI 483
+ + G+IIN S G +Y A+K A++GF R+L+ E K GI
Sbjct: 153 AEDMIDNREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLSTECNKTGI 212
Query: 484 TVNVIAP 490
++ P
Sbjct: 213 KTLLVCP 219
>At3g03980 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 67.8 bits (164), Expect = 7e-11
Identities = 68/203 (33%), Positives = 93/203 (45%), Gaps = 22/203 (10%)
Query: 305 PIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVIN---DIRDPSAVVDEIN----- 356
P+P L G+V I+TGS G+G++ A A GA++VIN D V EIN
Sbjct: 11 PLP---LAGRVAIVTGSSRGIGRAIAIHLAELGARIVINYTSKAADAERVASEINDFPVR 67
Query: 357 -KKYGSGSAVADTHDIVKEAQQV---VQTAVDKF-GRVDILVNNAGILRDR--SFAKMTE 409
+ G G V E QV A F V ILVN+AGIL + + A +
Sbjct: 68 EEITGKGPRAIVVQANVSEPSQVKSMFDAAESAFEAPVHILVNSAGILDPKYPTIADTSV 127
Query: 410 DEWNAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTS--TSGIYGNFGQCNYAAAKAAI 467
++++ +V+ F SK + G II TS T + FG YAA+KAA+
Sbjct: 128 EDFDHTFSVNTKGAFLCSKEAANRLKQGGGGRIILLTSSQTRSLKPGFGA--YAASKAAV 185
Query: 468 LGFSRTLALEGTKRGITVNVIAP 490
+ LA E GIT N +AP
Sbjct: 186 ETMVKILAKELKGTGITANCVAP 208
Score = 66.2 bits (160), Expect = 2e-10
Identities = 60/197 (30%), Positives = 97/197 (48%), Gaps = 13/197 (6%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSA-ADSVVQEI------KKLG 55
L RV I+TG+ G+GR A+ A+ G ++V+N ++A A+ V EI +++
Sbjct: 12 LPLAGRVAIVTGSSRGIGRAIAIHLAELGARIVINYTSKAADAERVASEINDFPVREEIT 71
Query: 56 GEGD-AVANYDSVSDNG--AAIVETAISNF-GRVDILINNAGIL--RDSSFAKMSEKQFQ 109
G+G A+ +VS+ ++ + A S F V IL+N+AGIL + + A S + F
Sbjct: 72 GKGPRAIVVQANVSEPSQVKSMFDAAESAFEAPVHILVNSAGILDPKYPTIADTSVEDFD 131
Query: 110 QVIDVHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGES 169
V+ GAF ++ A +++ GRII S G Y+A+K + +
Sbjct: 132 HTFSVNTKGAFLCSKEAANRLKQGGGGRIILLTSSQTRSLKPGFGAYAASKAAVETMVKI 191
Query: 170 LAKEGYKYNINVNSIAP 186
LAKE I N +AP
Sbjct: 192 LAKELKGTGITANCVAP 208
>At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 299
Score = 67.4 bits (163), Expect = 9e-11
Identities = 48/199 (24%), Positives = 89/199 (44%), Gaps = 26/199 (13%)
Query: 9 VVIITGAG-GGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
VV+ITG GG+G A E+ ++G +VV RS + Q+ + E D ++
Sbjct: 9 VVLITGCSQGGIGHALAREFTEKGCRVVATSRSRSTMTDLEQDSRLFVKELDVQSD---- 64
Query: 68 SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHL----------- 116
N + ++ I FG++D+L+NNAG+ A+ + + ++
Sbjct: 65 -QNVSKVLSEVIDKFGKIDVLVNNAGVQCVGPLAETPISAMENTFNTNVFGNKDLIFSFN 123
Query: 117 ---------NGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFG 167
+G+ ++T+A PHM +K G+I+N S + Y+A K +
Sbjct: 124 YYIYWSFNSSGSMRMTQAVVPHMVSKKKGKIVNVGSITVMAPGPWAGVYTATKAAIHALT 183
Query: 168 ESLAKEGYKYNINVNSIAP 186
++L E + I+V ++ P
Sbjct: 184 DTLRLELRPFGIDVINVVP 202
Score = 58.2 bits (139), Expect = 6e-08
Identities = 58/200 (29%), Positives = 95/200 (47%), Gaps = 30/200 (15%)
Query: 315 VVIITG-SGSGLGKSHAQWFARYGAKVVINDIRDPSAVVD--EINKKYGSGSAVADTHDI 371
VV+ITG S G+G + A+ F G +VV R S + D + ++ + V ++
Sbjct: 9 VVLITGCSQGGIGHALAREFTEKGCRVVATS-RSRSTMTDLEQDSRLFVKELDVQSDQNV 67
Query: 372 VKEAQQVVQTAVDKFGRVDILVNNAGI-----LRDRSFAKMTEDEWNAVI---------- 416
K V+ +DKFG++D+LVNNAG+ L + + M E+ +N +
Sbjct: 68 SK----VLSEVIDKFGKIDVLVNNAGVQCVGPLAETPISAM-ENTFNTNVFGNKDLIFSF 122
Query: 417 NVHLFSTF------ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGF 470
N +++ +F +++AV P + +K G I+N S + + Y A KAAI
Sbjct: 123 NYYIYWSFNSSGSMRMTQAVVPHMVSKKKGKIVNVGSITVMAPGPWAGVYTATKAAIHAL 182
Query: 471 SRTLALEGTKRGITVNVIAP 490
+ TL LE GI V + P
Sbjct: 183 TDTLRLELRPFGIDVINVVP 202
>SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 236
Score = 67.0 bits (162), Expect = 1e-10
Identities = 54/190 (28%), Positives = 92/190 (48%), Gaps = 14/190 (7%)
Query: 316 VIITGSGSGLGKSHAQWFARYGAKVVI---NDIRDPSAVVD-EINKKYGSGSAVADTHDI 371
V+ITG SGLGK AQ +++ G + I N+ + + K +AD
Sbjct: 4 VLITGGSSGLGKRIAQIWSQKGHQCHIVGRNEFHLKETLQSLSVAKGQQHTLTIADVQSD 63
Query: 372 VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKAVW 431
+K + + ++ +D +V+ AG+L+ + +E E +++I +L S LSK
Sbjct: 64 MKNLKSIFESV-----EIDTVVHAAGVLQSSLCVRTSEKEIDSIICTNLVSAIKLSKMAI 118
Query: 432 PIFLKQKSG----YIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNV 487
+ + K+ I+N +S Y G YAA+KA + F++ LA E +GI VN
Sbjct: 119 LEWFRNKNSERDRLILNISSRLSTYALPGTSVYAASKAGLESFTKVLAAEVASKGIRVNA 178
Query: 488 IAP-HAETAM 496
I+P + +T M
Sbjct: 179 ISPGYVDTPM 188
Score = 65.9 bits (159), Expect = 3e-10
Identities = 53/185 (28%), Positives = 88/185 (46%), Gaps = 11/185 (5%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
R V+ITG GLG+ A ++++G + + +Q + G+ + D
Sbjct: 2 RKVLITGGSSGLGKRIAQIWSQKGHQCHIVGRNEFHLKETLQSLSVAKGQQHTLTIADVQ 61
Query: 68 SD--NGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRA 125
SD N +I E+ +D +++ AG+L+ S + SEK+ +I +L A KL++
Sbjct: 62 SDMKNLKSIFESV-----EIDTVVHAAGVLQSSLCVRTSEKEIDSIICTNLVSAIKLSKM 116
Query: 126 A---WPHMRKQKFGRII-NTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINV 181
A W + + R+I N S Y G + Y+A+K GL F + LA E I V
Sbjct: 117 AILEWFRNKNSERDRLILNISSRLSTYALPGTSVYAASKAGLESFTKVLAAEVASKGIRV 176
Query: 182 NSIAP 186
N+I+P
Sbjct: 177 NAISP 181
>CE13054 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 240
Score = 67.0 bits (162), Expect = 1e-10
Identities = 43/141 (30%), Positives = 69/141 (48%), Gaps = 5/141 (3%)
Query: 80 SNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPHMRKQKFGRII 139
S G+VDIL+NNAGI+ + ++ + + V+ N F T+ P M + G I+
Sbjct: 45 SEVGKVDILVNNAGIVTGKKLLQCPDELMVKTVSVNTNALFFTTKNFLPGMLESNKGHIV 104
Query: 140 NTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGY--KYNINVNSIAPL-ARSAMTENV 196
S AG G G +Y A+K G +GF +SLA E Y K ++ + P+ + M + +
Sbjct: 105 TIASMAGKCGVAGLVDYCASKHGAVGFNDSLASELYALKKDVKTTVVCPIYINTGMFDGI 164
Query: 197 IP--ANILKELGPEKIAPLIL 215
+L L PE + I+
Sbjct: 165 ATKWPTLLPILSPEYVVDCIM 185
Score = 60.5 bits (145), Expect = 1e-08
Identities = 35/120 (29%), Positives = 60/120 (49%), Gaps = 2/120 (1%)
Query: 373 KEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKAVWP 432
KE + + G+VDILVNNAGI+ + + ++ ++V+ + F +K P
Sbjct: 34 KEINRTADLVKSEVGKVDILVNNAGIVTGKKLLQCPDELMVKTVSVNTNALFFTTKNFLP 93
Query: 433 IFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE--GTKRGITVNVIAP 490
L+ G+I+ S +G G G +Y A+K +GF+ +LA E K+ + V+ P
Sbjct: 94 GMLESNKGHIVTIASMAGKCGVAGLVDYCASKHGAVGFNDSLASELYALKKDVKTTVVCP 153
>At2g29290 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 67.0 bits (162), Expect = 1e-10
Identities = 57/229 (24%), Positives = 105/229 (44%), Gaps = 16/229 (6%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTH 369
SL+G ++TG G+G++ + + GA+V RD + + + + + G V +
Sbjct: 6 SLQGMNALVTGGTKGIGEAVVEELSILGARVH-TCARDETQLQERLREWQEKGFQVTTSI 64
Query: 370 ---DIVKEAQQVVQTAVDKF-GRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
+ ++ +++++T F G+++ILVNN G L + + T +E++ ++ +L S F
Sbjct: 65 CDVSLREQREKLMETVSSLFQGKLNILVNNVGTLMLKPTTEYTAEEFSFLMATNLDSAFH 124
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
+S+ P+ SG I+ +S +G+ Y A K A+ +R LA E I
Sbjct: 125 ISQLAHPLLKASGSGSIVLMSSIAGVVHVGVGSIYGATKGAMNQLARNLACEWASDNIRT 184
Query: 486 NVIAPH-AETAMTKTIFSSKELNNHF----------DPGFVSPFVVLLC 523
N I P T + + S +E+ + VSP V LC
Sbjct: 185 NAICPWLITTPLISDLLSVEEMKKEAEERTPMGRVGEANEVSPLVAFLC 233
Score = 55.1 bits (131), Expect = 5e-07
Identities = 49/220 (22%), Positives = 99/220 (44%), Gaps = 13/220 (5%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TG G+G E + G +V + ++E ++ G + S+ +
Sbjct: 13 LVTGGTKGIGEAVVEELSILGARVHTCARDETQLQERLREWQEKGFQVTTSICDVSLREQ 72
Query: 71 GAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
++ET S F G+++IL+NN G L + + ++F ++ +L+ AF +++ A P
Sbjct: 73 REKLMETVSSLFQGKLNILVNNVGTLMLKPTTEYTAEEFSFLMATNLDSAFHISQLAHPL 132
Query: 130 MRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP-LA 188
++ G I+ S AG+ + Y A K + +LA E NI N+I P L
Sbjct: 133 LKASGSGSIVLMSSIAGVVHVGVGSIYGATKGAMNQLARNLACEWASDNIRTNAICPWLI 192
Query: 189 RSAMTENVIPANILKELGPEK-----------IAPLILYL 217
+ + +++ +K+ E+ ++PL+ +L
Sbjct: 193 TTPLISDLLSVEEMKKEAEERTPMGRVGEANEVSPLVAFL 232
>At2g29170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 67.0 bits (162), Expect = 1e-10
Identities = 52/185 (28%), Positives = 90/185 (48%), Gaps = 5/185 (2%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKV---VINDIRDPSAVVDEINKKYGSGSAVA 366
SL G ++TG GLG++ + A GA+V N+ + V + K + ++V
Sbjct: 15 SLGGMTALVTGGSKGLGEAVVEELAMLGARVHTCARNETQLQECVREWQAKGFEVTTSVC 74
Query: 367 DTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFAL 426
D + + + A G+++ILVNNAG + + T +++ ++ +L S F L
Sbjct: 75 DVSSRDQREKLMENVASIFQGKLNILVNNAGTGITKPTTEYTAQDYSFLMATNLDSAFHL 134
Query: 427 SKAVWPIFLKQKSGYIINTTSTSG-IYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
S+ P+ SG I+ +ST+G ++ N G Y A K A+ ++ LA E + I V
Sbjct: 135 SQLAHPLLKASGSGSIVLMSSTAGVVHINVGSI-YGATKGAMNQLAKNLACEWARDNIRV 193
Query: 486 NVIAP 490
N + P
Sbjct: 194 NSVCP 198
Score = 60.8 bits (146), Expect = 9e-09
Identities = 48/177 (27%), Positives = 80/177 (45%), Gaps = 1/177 (0%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TG GLG E A G +V + V+E + G E S D
Sbjct: 22 LVTGGSKGLGEAVVEELAMLGARVHTCARNETQLQECVREWQAKGFEVTTSVCDVSSRDQ 81
Query: 71 GAAIVETAISNF-GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
++E S F G+++IL+NNAG + + + + ++ +L+ AF L++ A P
Sbjct: 82 REKLMENVASIFQGKLNILVNNAGTGITKPTTEYTAQDYSFLMATNLDSAFHLSQLAHPL 141
Query: 130 MRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
++ G I+ S AG+ + Y A K + ++LA E + NI VNS+ P
Sbjct: 142 LKASGSGSIVLMSSTAGVVHINVGSIYGATKGAMNQLAKNLACEWARDNIRVNSVCP 198
>YMR226c [Q] KOG1205 Predicted dehydrogenase
Length = 267
Score = 65.9 bits (159), Expect = 3e-10
Identities = 66/244 (27%), Positives = 108/244 (44%), Gaps = 28/244 (11%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA------- 60
+ V+ITGA G+G+ ALEY + D+ A ++++++L D
Sbjct: 14 KTVLITGASAGIGKATALEYLEASN----GDMKLILAARRLEKLEELKKTIDQEFPNAKV 69
Query: 61 -VANYD-SVSDNGAAIVETAISNFGRVDILINNAG-ILRDSSFAKMSEKQFQQVIDVHLN 117
VA D + ++ +E F +DIL+NNAG L +++ + Q V D ++
Sbjct: 70 HVAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVT 129
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
+T+A P + + G I+N S AG + Y A+K + F +SL KE
Sbjct: 130 ALINITQAVLPIFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELINT 189
Query: 178 NINVNSIAP--------LARSAMTENVIPANILKELGP---EKIAPLILYLT--HENTKV 224
I V IAP L R E N+ K+ P + +A LI+Y T +NT +
Sbjct: 190 KIRVILIAPGLVETEFSLVRYRGNEEQ-AKNVYKDTTPLMADDVADLIVYATSRKQNTVI 248
Query: 225 TNNI 228
+ +
Sbjct: 249 ADTL 252
Score = 55.1 bits (131), Expect = 5e-07
Identities = 57/190 (30%), Positives = 93/190 (48%), Gaps = 12/190 (6%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWF--ARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
L K V+ITG+ +G+GK+ A + A G +I R + +E+ K A
Sbjct: 11 LAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKL-EELKKTIDQEFPNAKV 69
Query: 369 HDI---VKEAQQV---VQTAVDKFGRVDILVNNAG--ILRDRSFAKMTEDEWNAVINVHL 420
H + +A+++ ++ +F +DILVNNAG + DR TED + V + ++
Sbjct: 70 HVAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQD-VFDTNV 128
Query: 421 FSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTK 480
+ +++AV PIF + SG I+N S +G Y A+K A+ F+ +L E
Sbjct: 129 TALINITQAVLPIFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELIN 188
Query: 481 RGITVNVIAP 490
I V +IAP
Sbjct: 189 TKIRVILIAP 198
>CE14538 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 65.9 bits (159), Expect = 3e-10
Identities = 54/198 (27%), Positives = 87/198 (43%), Gaps = 17/198 (8%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA 60
M+ F D V I+TG+ G+GR A+ A G KV + + Q + K+G
Sbjct: 1 MAQRFTDEVAIVTGSSNGIGRATAILLASEGAKVTITGRNAERLEESRQALLKVGVPSGH 60
Query: 61 VANYDSVSDNGA---AIVETAISNFGRVDILINNAGIL--------RDSSFAKMSEKQFQ 109
+ + + GA ++++ + FG+++ILINNAG L S+ + K FQ
Sbjct: 61 INSVVADVTTGAGQDVLIDSTLKKFGKINILINNAGALIVDPEGKTNTSTGVETCLKTFQ 120
Query: 110 QVIDVHLNGAFKLTRAAWPHMRKQKFGRIINTCS-PAGLYGNFGQANYSAAKLGLLGFGE 168
++ ++T+ PH+ G I+N S AG YSAAK L +
Sbjct: 121 ----LNFQSVVEMTQKIRPHL-ANTHGEIVNVSSVGAGPAAENRFPYYSAAKAALDQYSR 175
Query: 169 SLAKEGYKYNINVNSIAP 186
+ A + I VN + P
Sbjct: 176 NTAIDLIPDGIRVNIVQP 193
Score = 59.7 bits (143), Expect = 2e-08
Identities = 53/187 (28%), Positives = 90/187 (47%), Gaps = 11/187 (5%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVI---NDIRDPSAVVDEINKKYGSGSAVADTHD 370
+V I+TGS +G+G++ A A GAKV I N R + + SG + D
Sbjct: 8 EVAIVTGSSNGIGRATAILLASEGAKVTITGRNAERLEESRQALLKVGVPSGHINSVVAD 67
Query: 371 IVKEAQQ--VVQTAVDKFGRVDILVNNAGIL----RDRSFAKMTEDEWNAVINVHLFSTF 424
+ A Q ++ + + KFG+++IL+NNAG L ++ + ++ S
Sbjct: 68 VTTGAGQDVLIDSTLKKFGKINILINNAGALIVDPEGKTNTSTGVETCLKTFQLNFQSVV 127
Query: 425 ALSKAVWPIFLKQKSGYIINTTST-SGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
+++ + P L G I+N +S +G Y+AAKAA+ +SR A++ GI
Sbjct: 128 EMTQKIRP-HLANTHGEIVNVSSVGAGPAAENRFPYYSAAKAALDQYSRNTAIDLIPDGI 186
Query: 484 TVNVIAP 490
VN++ P
Sbjct: 187 RVNIVQP 193
>At3g04000 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 272
Score = 65.9 bits (159), Expect = 3e-10
Identities = 72/260 (27%), Positives = 117/260 (44%), Gaps = 41/260 (15%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVN-DLGRSAADSVVQEI-------KKLGGEGD 59
RV I+TG+ G+GR A+ A+ G +VVVN A+ V I ++ G+
Sbjct: 17 RVAIVTGSSRGIGRAIAIHLAELGARVVVNYSTSPVEAEKVATAITTNCSKDAEVAGKSP 76
Query: 60 AV----------ANYDSVSDNGAAIVETAISNFGRVDILINNAGIL--RDSSFAKMSEKQ 107
V + S+ D + E+ V IL+N+A I S+ + MS +
Sbjct: 77 RVIVVKADISEPSQVKSLFDEAERVFESP------VHILVNSAAIADPNHSTISDMSVEL 130
Query: 108 FQQVIDVHLNGAFKLTRAAWPHMRKQKFGRII--NTCSPAGLYGNFGQANYSAAKLGLLG 165
F ++I V+ GAF R A +++ GRII +T L N+G +Y+A+K +
Sbjct: 131 FDRIISVNTRGAFICAREAANRLKRGGGGRIILLSTSLVQTLNTNYG--SYTASKAAVEA 188
Query: 166 FGESLAKE--GYKYNINVNSIAPLA--------RSAMTENVIPANILKELGPEK-IAPLI 214
+ LAKE G + +N S P+A + + E V N+ +G K IAP++
Sbjct: 189 MAKILAKELKGTEITVNCVSPGPVATEMFYTGLSNEIVEKVKSQNLFGRIGETKDIAPVV 248
Query: 215 LYLTHENTKVTNNIFELAAG 234
+L + + N +A G
Sbjct: 249 GFLASDAGEWINGQVIMANG 268
Score = 57.0 bits (136), Expect = 1e-07
Identities = 57/203 (28%), Positives = 95/203 (46%), Gaps = 22/203 (10%)
Query: 307 PIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP-------SAVVDEINKK- 358
P L G+V I+TGS G+G++ A A GA+VV+N P +A+ +K
Sbjct: 10 PPLCLAGRVAIVTGSSRGIGRAIAIHLAELGARVVVNYSTSPVEAEKVATAITTNCSKDA 69
Query: 359 --YGSGSAVADTHDIVKEAQQVVQTAVDKFGR-----VDILVNNAGIL--RDRSFAKMTE 409
G V + E Q V++ D+ R V ILVN+A I + + M+
Sbjct: 70 EVAGKSPRVIVVKADISEPSQ-VKSLFDEAERVFESPVHILVNSAAIADPNHSTISDMSV 128
Query: 410 DEWNAVINVHLFSTFALSKAVWPIFLKQKSGYII--NTTSTSGIYGNFGQCNYAAAKAAI 467
+ ++ +I+V+ F ++ + G II +T+ + N+G +Y A+KAA+
Sbjct: 129 ELFDRIISVNTRGAFICAREAANRLKRGGGGRIILLSTSLVQTLNTNYG--SYTASKAAV 186
Query: 468 LGFSRTLALEGTKRGITVNVIAP 490
++ LA E ITVN ++P
Sbjct: 187 EAMAKILAKELKGTEITVNCVSP 209
>7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 278
Score = 65.9 bits (159), Expect = 3e-10
Identities = 54/201 (26%), Positives = 86/201 (41%), Gaps = 22/201 (10%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGG-KVVVNDLGRSAADSVVQEIKKLGG----E 57
+ F+ + ++TG GG+G + + G KV + DL + ++E KL +
Sbjct: 18 MSFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDN-----LEEFVKLRAAHPTQ 72
Query: 58 GDAVANYDSVSDNGA-AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHL 116
+ D + G A E FG +DI++N AGI D K Q+ + V+L
Sbjct: 73 SVMIIKMDVANKKGVEATYEEIAKTFGNIDIVVNVAGIFND--------KDVQRTLLVNL 124
Query: 117 NGAFKLTRAAWPHMRKQKFGR---IINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
G T +A P+M K G+ ++N S GL F Y A K G++ F LA E
Sbjct: 125 GGIINSTLSALPYMGKDNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANE 184
Query: 174 GYKYNINVNSIAPLARSAMTE 194
Y + + + MT+
Sbjct: 185 KYYQRSGIKFVTVCPGATMTD 205
Score = 63.5 bits (153), Expect = 1e-09
Identities = 56/200 (28%), Positives = 86/200 (43%), Gaps = 10/200 (5%)
Query: 310 SLRGKVVIITGSGSGLG-KSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
S RGK ++TG G+G + Q A AKV I D++D ++ + + S +
Sbjct: 19 SFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVMIIK 78
Query: 369 HDIV--KEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFAL 426
D+ K + + FG +DI+VN AGI D+ + +IN L + +
Sbjct: 79 MDVANKKGVEATYEEIAKTFGNIDIVVNVAGIFNDKDVQRTLLVNLGGIINSTLSALPYM 138
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEG--TKRGIT 484
K K G ++N +S G+ F Y A KA I+ F+R LA E + GI
Sbjct: 139 GKDNGG-----KGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGIK 193
Query: 485 VNVIAPHAETAMTKTIFSSK 504
+ P A T F+ K
Sbjct: 194 FVTVCPGATMTDMFTNFTEK 213
>Hs4759084 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 302
Score = 65.5 bits (158), Expect = 4e-10
Identities = 51/197 (25%), Positives = 90/197 (44%), Gaps = 5/197 (2%)
Query: 305 PIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSA 364
P ++ L + V+ITG G G+G+ A+ FA GA+ ++ R + + + G+
Sbjct: 30 PAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTE 89
Query: 365 VADTHDIVKEAQQVVQTAV---DKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
V ++V QTA +K G + ILVNNA ++ +S +D +++
Sbjct: 90 CHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTL 149
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTK- 480
F +KA P L+ ++G+I+ S + G +Y +KA+ F +L L
Sbjct: 150 GQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDC 209
Query: 481 RGITVNVIAP-HAETAM 496
G++ + P H T M
Sbjct: 210 PGVSATTVLPFHTSTEM 226
Score = 62.0 bits (149), Expect = 4e-09
Identities = 48/166 (28%), Positives = 74/166 (43%), Gaps = 9/166 (5%)
Query: 10 VIITGAGGGLGRVYALEYAKRGG-KVVVNDLGRSAADSVVQEIKKLGGEGDA----VANY 64
V+ITG G G+GR A E+A+RG K+V+ +EI+++G E V N
Sbjct: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNR 100
Query: 65 DSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTR 124
+ V A+ E G + IL+NNA ++ S + + ++ G F T+
Sbjct: 101 EEVYQTAKAVREKV----GDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTK 156
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESL 170
A P M + + G I+ S L G +Y +K F ESL
Sbjct: 157 AFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESL 202
>7295622 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 65.1 bits (157), Expect = 5e-10
Identities = 64/226 (28%), Positives = 101/226 (44%), Gaps = 20/226 (8%)
Query: 7 DRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSA--ADSVVQEIK-KLGGEGDAVAN 63
DRV ++TGA G+G A G V+V L R ++ +++ +L G A+
Sbjct: 6 DRVAVVTGASSGIGAAVARHLVSAG--VIVVGLARRVDRMKAIKEQLPPELQGRLHAIHC 63
Query: 64 YDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLT 123
D+ A + G DIL+NNAG L + +Q QQV++V+L G T
Sbjct: 64 DVEDLDSVTAAFDWIEEQLGGCDILVNNAGCLNPGQLLTLELEQLQQVLNVNLMGVVICT 123
Query: 124 RAAWPHMRKQKFGR---IINTCSPAGLYGNFGQA-----NYSAAKLGLLGFGESLAKE-- 173
R A+ M++++ +IN+ + + G Y K G+ E L +E
Sbjct: 124 RRAFRSMQQREVDGHVILINSLTGRNIINPPGDELQVLNMYPLTKHGVTAMLEVLRQELR 183
Query: 174 GYKYNINVNSIAPLARSAMTENVIPA--NILKELGPEKIAPLILYL 217
G+K I V SI P ++P+ IL L P+ IA I+Y+
Sbjct: 184 GFKTKIKVTSITP---GVTDTEILPSGYGILPMLKPDDIAAGIMYV 226
>CE07544 [Q] KOG1205 Predicted dehydrogenase
Length = 262
Score = 64.7 bits (156), Expect = 6e-10
Identities = 52/183 (28%), Positives = 88/183 (47%), Gaps = 8/183 (4%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLG--GEGDA 60
L+ K++VV+ITGA GLG+ A E KRG +V++ + +E+K+ + +
Sbjct: 43 LDVKNKVVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICEELKETFPLNQNEP 102
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
+ Y ++D+ A + RVDILINNAG+ S + + +Q ++ + G
Sbjct: 103 IYYYFDITDSEQA----PWAEIPRVDILINNAGMSNRGSCQDTTMEIHRQAMETNYFGHV 158
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
+T+A + G I+ T S G + +Y A+K L G+ + L E +I
Sbjct: 159 HVTQALLSKLSPD--GCIVVTSSIQGKVAIPYRGSYGASKHALQGYFDCLRAEHKNLHIL 216
Query: 181 VNS 183
V S
Sbjct: 217 VVS 219
>7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 321
Score = 64.3 bits (155), Expect = 8e-10
Identities = 53/192 (27%), Positives = 87/192 (44%), Gaps = 15/192 (7%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVI--NDIRDPSAVVDEINKKYGSGSAVAD 367
S G+ ++TGS G+GK++A+ AR G K+V+ + + V EI KYG V D
Sbjct: 49 SKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVID 108
Query: 368 TH----DIVKEAQQVVQTAVDKFGRVDILVNNAGILRDR-----SFAKMTEDEWNAVINV 418
D + + + T ++ V +LVNN GI K ++
Sbjct: 109 VDFTGGDEIYDKIREKTTGLN----VGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAA 164
Query: 419 HLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEG 478
++ S ++ P + Q+ G IIN +ST+G+ N Y++ KA + FS L E
Sbjct: 165 NIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEY 224
Query: 479 TKRGITVNVIAP 490
+ GI + + P
Sbjct: 225 KEHGILIQSVQP 236
Score = 56.2 bits (134), Expect = 2e-07
Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 27/192 (14%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEI-KKLGGE----------GD 59
++TG+ G+G+ YA E A+RG K+V+ + V +EI K G E GD
Sbjct: 56 VVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGD 115
Query: 60 AVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDS-----SFAKMSEKQFQQVIDV 114
+ YD + + + V +L+NN GI K + ++
Sbjct: 116 EI--YDKIREKTTGL---------NVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAA 164
Query: 115 HLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEG 174
+++ +T P M Q+ G IIN S AG+ N + YS+ K + F + L E
Sbjct: 165 NIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEY 224
Query: 175 YKYNINVNSIAP 186
++ I + S+ P
Sbjct: 225 KEHGILIQSVQP 236
>YIR035c [Q] KOG1204 Predicted dehydrogenase
Length = 254
Score = 63.5 bits (153), Expect = 1e-09
Identities = 51/183 (27%), Positives = 89/183 (47%), Gaps = 11/183 (6%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSG--SAVAD-TH 369
GKV+++TG G+GKS V+ + A + ++ +KYG V D T
Sbjct: 2 GKVILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEAPLKKLKEKYGDRFFYVVGDITE 61
Query: 370 DIVKEAQQVVQTAVDKFGRVDILVNNAGILRD-RSFAKMTEDEWNAVINVHLFSTFALSK 428
D V +Q+V AV G++D LV NAG+L ++ ++ + W + +++ FS +L
Sbjct: 62 DSV--LKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSLVG 119
Query: 429 AVWPIFLKQKSGYIINTTSTSGIY-GNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNV 487
P K + ++ +Y ++G Y ++KAA+ F+ TLA E +R +
Sbjct: 120 IALPELKKTNGNVVFVSSDACNMYFSSWGA--YGSSKAALNHFAMTLANE--ERQVKAIA 175
Query: 488 IAP 490
+AP
Sbjct: 176 VAP 178
>At4g13180 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 263
Score = 63.5 bits (153), Expect = 1e-09
Identities = 56/190 (29%), Positives = 92/190 (47%), Gaps = 12/190 (6%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPS---AVVDEINKKYGSGSAVAD 367
L G+V I+TG+ G+G+ A GA+V IN + S +V E+N SA+A
Sbjct: 13 LAGRVAIVTGATRGMGREIAIHLHSLGARVTINYVSSSSKAELLVSELNDSSQLKSAIAV 72
Query: 368 THDIVKEAQ--QVVQTAVDKFG-RVDILVNNAGILRDR--SFAKMTEDEWNAVINVHLFS 422
D+ Q + +FG +V I+VN AG+L + S ++ T ++++ ++
Sbjct: 73 KADVSDPDQINNLFDQTEQEFGSKVHIVVNCAGVLDPKYPSLSETTLEDFDNTFTINTRG 132
Query: 423 TFALSKAVWPIFLKQKSGYII--NTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTK 480
+F K ++ G II +T+ G+ +G YAA+KAA+ + LA E
Sbjct: 133 SFLCCKEAAKRVMRGGGGRIIMMSTSMVGGLAPGYGV--YAASKAAVETMVKVLAKELKG 190
Query: 481 RGITVNVIAP 490
IT N +AP
Sbjct: 191 SRITANCVAP 200
Score = 63.2 bits (152), Expect = 2e-09
Identities = 58/194 (29%), Positives = 91/194 (46%), Gaps = 12/194 (6%)
Query: 2 SLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSA-ADSVVQEIKKLGGEGDA 60
SL RV I+TGA G+GR A+ G +V +N + S+ A+ +V E+ A
Sbjct: 10 SLPLAGRVAIVTGATRGMGREIAIHLHSLGARVTINYVSSSSKAELLVSELNDSSQLKSA 69
Query: 61 VANYDSVSDNGAA--IVETAISNFG-RVDILINNAGILRDSSFAKMSE---KQFQQVIDV 114
+A VSD + + FG +V I++N AG+L D + +SE + F +
Sbjct: 70 IAVKADVSDPDQINNLFDQTEQEFGSKVHIVVNCAGVL-DPKYPSLSETTLEDFDNTFTI 128
Query: 115 HLNGAFKLTRAAWPHMRKQKFGRII--NTCSPAGLYGNFGQANYSAAKLGLLGFGESLAK 172
+ G+F + A + + GRII +T GL +G Y+A+K + + LAK
Sbjct: 129 NTRGSFLCCKEAAKRVMRGGGGRIIMMSTSMVGGLAPGYGV--YAASKAAVETMVKVLAK 186
Query: 173 EGYKYNINVNSIAP 186
E I N +AP
Sbjct: 187 ELKGSRITANCVAP 200
>7297912 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 299
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/166 (30%), Positives = 74/166 (44%), Gaps = 19/166 (11%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLG-GEGDAVANYDSV 67
+V+ITG G G+GR AL YA G VV D+ V++ K+L GE + + S
Sbjct: 56 IVLITGTGHGIGRELALHYASLGSTVVCVDIDGKNNLQTVEKAKRLNLGEVYSYSCDVSK 115
Query: 68 SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAW 127
D A+ + S+ G + +L+NN GI+ + S ++ Q+V D
Sbjct: 116 RDEVTALADRIKSDVGCISVLVNNVGIMPTHPILQQSAEEIQRVFD-------------- 161
Query: 128 PHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE 173
++ G II S AGL G Y A K + G E+L E
Sbjct: 162 ----EKCRGHIICMSSIAGLVGISNLVPYCATKFAVRGLMEALHAE 203
Score = 55.1 bits (131), Expect = 5e-07
Identities = 50/196 (25%), Positives = 84/196 (42%), Gaps = 29/196 (14%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAV-VDEINKKYGSGSAVAD 367
K + G++V+ITG+G G+G+ A +A G+ VV DI + + E K+ G +
Sbjct: 50 KDVSGEIVLITGTGHGIGRELALHYASLGSTVVCVDIDGKNNLQTVEKAKRLNLGEVYSY 109
Query: 368 THDIVK--EAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
+ D+ K E + G + +LVNN GI+ + + +E
Sbjct: 110 SCDVSKRDEVTALADRIKSDVGCISVLVNNVGIMPTHPILQQSAEE-------------- 155
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
+ +F ++ G+II +S +G+ G Y A K A+ G L E ++G
Sbjct: 156 ----IQRVFDEKCRGHIICMSSIAGLVGISNLVPYCATKFAVRGLMEALHAE-LRQG--- 207
Query: 486 NVIAPHAETAMTKTIF 501
P + T TIF
Sbjct: 208 ----PFRDLIRTTTIF 219
>7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 339
Score = 62.8 bits (151), Expect = 2e-09
Identities = 53/185 (28%), Positives = 92/185 (49%), Gaps = 8/185 (4%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPS--AVVDEINKKYGSGSAVADTHD 370
G+ ++TG+ G+GK +A+ AR G +V+ AV +EI +Y + D
Sbjct: 70 GQWAVVTGATDGIGKEYARELARQGINLVLISRTKEKLIAVTNEIESQYKVKTKWIAA-D 128
Query: 371 IVKEAQQVVQTAVDKFG-RVDILVNNAGILRDR--SFAKMTEDE-WNAVINVHLFSTFAL 426
K + Q + G V ILVNN G++ + S ++ED WN ++ V++ S L
Sbjct: 129 FAKGREVYDQIEKELAGIDVGILVNNVGMMYEHPESLDLVSEDLLWN-LLTVNMGSVTML 187
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
++ + P + ++ G I+N S+S + YAA+K + FS+ L LE + I V
Sbjct: 188 TRKILPQMIGRRKGAIVNLGSSSELQPLPNMTVYAASKKFVTYFSKALELEVAEHNIHVQ 247
Query: 487 VIAPH 491
++ P+
Sbjct: 248 LVMPN 252
Score = 55.1 bits (131), Expect = 5e-07
Identities = 50/189 (26%), Positives = 85/189 (44%), Gaps = 24/189 (12%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLG-----------GEGD 59
++TGA G+G+ YA E A++G +V+ + +V EI+ +G
Sbjct: 74 VVTGATDGIGKEYARELARQGINLVLISRTKEKLIAVTNEIESQYKVKTKWIAADFAKGR 133
Query: 60 AVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRD--SSFAKMSEKQFQQVIDVHLN 117
V YD + A I V IL+NN G++ + S +SE ++ V++
Sbjct: 134 EV--YDQIEKELAGI---------DVGILVNNVGMMYEHPESLDLVSEDLLWNLLTVNMG 182
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
LTR P M ++ G I+N S + L Y+A+K + F ++L E ++
Sbjct: 183 SVTMLTRKILPQMIGRRKGAIVNLGSSSELQPLPNMTVYAASKKFVTYFSKALELEVAEH 242
Query: 178 NINVNSIAP 186
NI+V + P
Sbjct: 243 NIHVQLVMP 251
>SPCC1739.08c [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 62.4 bits (150), Expect = 3e-09
Identities = 53/188 (28%), Positives = 90/188 (47%), Gaps = 11/188 (5%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIR-DPSAVVDEINKKYGSGSAVADT 368
SL+GK ++ G+ G+G S A FA+ G V+I + DP+ ++ ++ G T
Sbjct: 18 SLKGKNCVVFGAAKGIGFSIATAFAQAGGNVIITYLTTDPTEKAKKLAEETG---VQVHT 74
Query: 369 HDIVKEAQQVVQTAVDK----FGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTF 424
I V+ V++ F + ++V NAG+ RS E+ V+N++ S +
Sbjct: 75 LKIDISRSDTVEAGVEEIQKIFKEIHVVVANAGMPFRRSVLDSPPHEFEKVMNINTNSVY 134
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQ--CNYAAAKAAILGFSRTLALEGTKRG 482
++ + IF KQ G +I T S S N Q Y A+KAA+ + LA+E +
Sbjct: 135 RVAYYMGKIFKKQGFGNLIATASMSATIVNAPQHIAAYCASKAAVRQLCKALAVEWAEFA 194
Query: 483 ITVNVIAP 490
+N ++P
Sbjct: 195 -RINSVSP 201
Score = 59.7 bits (143), Expect = 2e-08
Identities = 45/183 (24%), Positives = 86/183 (46%), Gaps = 3/183 (1%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
K + ++ GA G+G A +A+ GG V++ L + + ++ G + +
Sbjct: 20 KGKNCVVFGAAKGIGFSIATAFAQAGGNVIITYLTTDPTEKAKKLAEETGVQVHTLKIDI 79
Query: 66 SVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRA 125
S SD A VE F + +++ NAG+ S +F++V++++ N +++
Sbjct: 80 SRSDTVEAGVEEIQKIFKEIHVVVANAGMPFRRSVLDSPPHEFEKVMNINTNSVYRVAYY 139
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQ--ANYSAAKLGLLGFGESLAKEGYKYNINVNS 183
+KQ FG +I T S + N Q A Y A+K + ++LA E ++ +NS
Sbjct: 140 MGKIFKKQGFGNLIATASMSATIVNAPQHIAAYCASKAAVRQLCKALAVEWAEF-ARINS 198
Query: 184 IAP 186
++P
Sbjct: 199 VSP 201
>SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 62.0 bits (149), Expect = 4e-09
Identities = 51/206 (24%), Positives = 87/206 (41%), Gaps = 10/206 (4%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVD--EINKKYGSGSAVAD 367
S K+ I G G+G S + + VV R P A + E +K + + +
Sbjct: 2 STTNKIYFIAGGNRGIGLSLVKELSNREGTVVFASARKPEAATELQEWSKSHSNVHIIKL 61
Query: 368 THDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDE-WNAVINVHLFSTFAL 426
++ A + Q G+VD+L N+GI + T D+ WN+ ++ +
Sbjct: 62 DISSLESANEAAQEVAKAVGKVDVLWVNSGIFHSFNTVLNTPDDVWNSHYKTNVLGPIHV 121
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYG---NFGQCNYAAAKAAILGFSRTLALEGTKRGI 483
+A +P+ K +S I+ T+S G G F Q Y +KAA+ + ++ E G
Sbjct: 122 YQAFYPLVKKGESKIIVFTSSLVGSMGAFFPFNQSGYGQSKAALNFTMKEISFELQDEGF 181
Query: 484 TVNVIAPHAETAMTKTIFSSKELNNH 509
V I P M +T + + +N H
Sbjct: 182 IVISIHP----GMVRTDSAQEAVNQH 203
>HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 62.0 bits (149), Expect = 4e-09
Identities = 55/183 (30%), Positives = 90/183 (49%), Gaps = 6/183 (3%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSV-VQEIKKLGGEGDAVANY 64
+D+ V ITG G G++ A + RG +V+ L A+ + Q +L V
Sbjct: 28 RDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKT 87
Query: 65 DSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ-FQQVIDVHLNGAFKLT 123
+SV+ A V+ + + G L+NNAGI ++ ++ KQ F ++DV+L G +T
Sbjct: 88 ESVA-AAAQWVKECVRDKGLWG-LVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVT 145
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNS 183
+ P +RK + GR++N S G FG Y +K G+ F +SL +E + + V
Sbjct: 146 LSLLPLVRKAR-GRVVNVSSVMGRVSLFG-GGYCISKYGVEAFSDSLRRELSYFGVKVAM 203
Query: 184 IAP 186
I P
Sbjct: 204 IEP 206
Score = 53.9 bits (128), Expect = 1e-06
Identities = 57/204 (27%), Positives = 96/204 (46%), Gaps = 16/204 (7%)
Query: 308 IKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSA--VVDEINKKYGSGSA- 364
+ LR K V ITG SG GK A+ G +V+ + + A + + + + + +
Sbjct: 24 LSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLD 83
Query: 365 VADTHDIVKEAQQVVQTAVDK--FGRVDILVNNAGI-LRDRSFAKMTEDEWNAVINVHLF 421
V T + AQ V + DK +G LVNNAGI L +T+ ++ +++V+L
Sbjct: 84 VTKTESVAAAAQWVKECVRDKGLWG----LVNNAGISLPTAPNELLTKQDFVTILDVNLL 139
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
++ ++ P+ K + G ++N +S G FG Y +K + FS +L E +
Sbjct: 140 GVIDVTLSLLPLVRKAR-GRVVNVSSVMGRVSLFGG-GYCISKYGVEAFSDSLRRELSYF 197
Query: 482 GITVNVIAPHAETAMTKTIFSSKE 505
G+ V +I P KT +SKE
Sbjct: 198 GVKVAMIEP----GYFKTAVTSKE 217
>Hs4503301 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 335
Score = 62.0 bits (149), Expect = 4e-09
Identities = 56/211 (26%), Positives = 94/211 (44%), Gaps = 8/211 (3%)
Query: 306 IPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP--SAVVDEINKKYGS-- 361
+P S +GKV ITG G+GLGK + GA+ VI + A ++I+ + G+
Sbjct: 52 LPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKV 111
Query: 362 GSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLF 421
+ D D Q V + G +I++NNA +++ + W + ++ L
Sbjct: 112 HAIQCDVRD-PDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLN 170
Query: 422 STFALSKAVWPIFLK-QKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTK 480
T ++ + +K QK ++ T+ G+ A+AKA + S++LA E K
Sbjct: 171 GTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGK 230
Query: 481 RGITVNVIAPHAETAMTKTIFSSKELNNHFD 511
G+ NVI P TK FS + F+
Sbjct: 231 YGMRFNVIQP--GPIKTKGAFSRLDPTGTFE 259
>At4g05530 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 254
Score = 61.6 bits (148), Expect = 5e-09
Identities = 55/247 (22%), Positives = 108/247 (43%), Gaps = 19/247 (7%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+V I+T + G+G + G VVV+ ++ D V ++K G + + + S
Sbjct: 12 KVAIVTASTQGIGFGITERFGLEGASVVVSSRKQANVDEAVAKLKSKGIDAYGIVCHVSN 71
Query: 68 SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ--FQQVIDVHLNGAFKLTRA 125
+ + +VE + +G++DI++ NA S+ +S K+ ++ ++++ + L +
Sbjct: 72 AQHRRNLVEKTVQKYGKIDIVVCNAA-ANPSTDPILSSKEAVLDKLWEINVKSSILLLQD 130
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIA 185
PH+ +K +I S AG A Y K LLG ++LA E + VN++A
Sbjct: 131 MAPHL--EKGSSVIFITSIAGFSPQGAMAMYGVTKTALLGLTKALAAE-MAPDTRVNAVA 187
Query: 186 P-----------LARSAMTENVIPANILKELGP--EKIAPLILYLTHENTKVTNNIFELA 232
P S + E + +L LG + A + +++ +T +A
Sbjct: 188 PGFVPTHFASFITGSSEVREGIEEKTLLNRLGTTGDMAAAAAFLASDDSSYITGETLVVA 247
Query: 233 AGFYSQI 239
G S++
Sbjct: 248 GGMPSRL 254
Score = 56.6 bits (135), Expect = 2e-07
Identities = 53/189 (28%), Positives = 84/189 (44%), Gaps = 14/189 (7%)
Query: 309 KSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADT 368
+ L GKV I+T S G+G + F GA VV++ + A VDE K S D
Sbjct: 7 RRLEGKVAIVTASTQGIGFGITERFGLEGASVVVSSRK--QANVDEAVAKLKSKG--IDA 62
Query: 369 HDIV------KEAQQVVQTAVDKFGRVDILVNNAGILRDRS-FAKMTEDEWNAVINVHLF 421
+ IV + + +V+ V K+G++DI+V NA E + + +++
Sbjct: 63 YGIVCHVSNAQHRRNLVEKTVQKYGKIDIVVCNAAANPSTDPILSSKEAVLDKLWEINVK 122
Query: 422 STFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
S+ L + + P +K +I TS +G Y K A+LG ++ LA E
Sbjct: 123 SSILLLQDMAPHL--EKGSSVIFITSIAGFSPQGAMAMYGVTKTALLGLTKALAAE-MAP 179
Query: 482 GITVNVIAP 490
VN +AP
Sbjct: 180 DTRVNAVAP 188
>Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 343
Score = 60.5 bits (145), Expect = 1e-08
Identities = 51/199 (25%), Positives = 85/199 (42%), Gaps = 6/199 (3%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+ V++TG G G A +G V L + V+E+ L + +
Sbjct: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
Query: 68 SDNGAA-IVETAISNFGRVDI----LINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKL 122
S +VE S+ + L+NNAGI S + ++QV +V+L G ++
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRM 175
Query: 123 TRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVN 182
T++ P +R+ K GR++N S G N ++ Y K G+ F + L E Y + V+
Sbjct: 176 TKSFLPLIRRAK-GRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
Query: 183 SIAPLARSAMTENVIPANI 201
+ P A T P +I
Sbjct: 235 VVEPGNFIAATSLYSPESI 253
Score = 51.2 bits (121), Expect = 7e-06
Identities = 45/184 (24%), Positives = 82/184 (44%), Gaps = 8/184 (4%)
Query: 314 KVVIITGSGSGLGKS-----HAQWFARYGAKVVINDIRDPSAVVDEIN--KKYGSGSAVA 366
K V++TG SG G S H++ F + ++ + D +D +N + V
Sbjct: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
Query: 367 DTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFAL 426
+ ++ K + V + D + LVNNAGI + + + V V+L+ T +
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRM 175
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
+K+ P+ +++ G ++N +S G N + Y K + FS L E G+ V+
Sbjct: 176 TKSFLPL-IRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
Query: 487 VIAP 490
V+ P
Sbjct: 235 VVEP 238
>CE02315 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 309
Score = 60.5 bits (145), Expect = 1e-08
Identities = 54/198 (27%), Positives = 92/198 (46%), Gaps = 29/198 (14%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVI--NDIRDPSAVVDEINKKYG------- 360
+L+GKV ++TG G+G+GK+ A FA GA V I + +EI K G
Sbjct: 22 ALKGKVALVTGGGTGIGKAIATTFAHLGASVAIAARRMEKLEQTAEEIMKTTGGICEPFR 81
Query: 361 ----SGSAVADTHDIVKEAQQVVQTAVDKFGR-VDILVNNAGILRDRSFAKMTEDEWNAV 415
V+DT D + + KFG+ DILVNNA + +++ + +
Sbjct: 82 MDIKDPGMVSDTFDKIDK----------KFGKHPDILVNNAAGNFIMATERLSPNAHGTI 131
Query: 416 INVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQ---CNYAAAKAAILGFSR 472
I++ L T ++ + ++ K+G + TS + Y G A +KA + ++
Sbjct: 132 IDIVLKGTMNVTTELGKRCIQSKTG--ASVTSITAAYARSGAPFIVPSAVSKAGVEIMTK 189
Query: 473 TLALEGTKRGITVNVIAP 490
+LA E +K G+ N ++P
Sbjct: 190 SLATEWSKYGLRFNAVSP 207
Score = 57.0 bits (136), Expect = 1e-07
Identities = 61/266 (22%), Positives = 104/266 (38%), Gaps = 24/266 (9%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
K +V ++TG G G+G+ A +A G V + + +EI K G G
Sbjct: 24 KGKVALVTGGGTGIGKAIATTFAHLGASVAIAARRMEKLEQTAEEIMKTTG-GICEPFRM 82
Query: 66 SVSDNG--AAIVETAISNFGR-VDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKL 122
+ D G + + FG+ DIL+NNA + ++S +ID+ L G +
Sbjct: 83 DIKDPGMVSDTFDKIDKKFGKHPDILVNNAAGNFIMATERLSPNAHGTIIDIVLKGTMNV 142
Query: 123 TRAAWPHMRKQKFGRIINTCSPAGLYGNFGQ---ANYSAAKLGLLGFGESLAKEGYKYNI 179
T + K G + + + A Y G + +K G+ +SLA E KY +
Sbjct: 143 TTELGKRCIQSKTGASVTSITAA--YARSGAPFIVPSAVSKAGVEIMTKSLATEWSKYGL 200
Query: 180 NVNSIAP--------LARSAMTENVIPANILKELG-------PEKIAPLILYLTHENTKV 224
N+++P R E A +KEL PE++A L+ +++ ++
Sbjct: 201 RFNAVSPGPIPTKGAWGRLFSGEMGDVAEKMKELNPEGRSGTPEEVANLVAFISSDHMSF 260
Query: 225 TNNIFELAAGFYSQIRWERSSGELFH 250
N + G G+ H
Sbjct: 261 MNGVIIDLDGGQQHFNHGSHMGDFLH 286
>7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 308
Score = 60.5 bits (145), Expect = 1e-08
Identities = 50/181 (27%), Positives = 84/181 (45%), Gaps = 10/181 (5%)
Query: 12 ITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSD-- 69
+TGA G+G+ YA E A++ VV+ +V +EI G V ++D
Sbjct: 54 VTGASDGIGKEYAKELARQNINVVLIARTEEKLQAVAKEIADCGA---GVQTKIVIADFT 110
Query: 70 NGAAI---VETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAA 126
G+ + +E +N + IL+NN GI S K ++++ Q +ID ++ +L+R
Sbjct: 111 KGSQVYEHIEKETANIP-ISILVNNVGIATPKSLLKYNQEETQNIIDTNVVAVSQLSRIF 169
Query: 127 WPHMRKQKF-GRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIA 185
+ M+ K G I+N S L A Y+A+K +L E Y I+V ++
Sbjct: 170 FQRMKASKLKGAIVNVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQMLS 229
Query: 186 P 186
P
Sbjct: 230 P 230
Score = 53.5 bits (127), Expect = 1e-06
Identities = 47/190 (24%), Positives = 82/190 (42%), Gaps = 8/190 (4%)
Query: 308 IKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVAD 367
+K G +TG+ G+GK +A+ AR VV+ I + + K+ A
Sbjct: 44 LKERFGDWAAVTGASDGIGKEYAKELARQNINVVL--IARTEEKLQAVAKEIADCGAGVQ 101
Query: 368 THDIVKE---AQQVVQTAVDKFGRV--DILVNNAGILRDRSFAKMTEDEWNAVINVHLFS 422
T ++ + QV + + + ILVNN GI +S K ++E +I+ ++ +
Sbjct: 102 TKIVIADFTKGSQVYEHIEKETANIPISILVNNVGIATPKSLLKYNQEETQNIIDTNVVA 161
Query: 423 TFALSKAVWPIFLKQK-SGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKR 481
LS+ + K G I+N S + + YAA+KA + L E
Sbjct: 162 VSQLSRIFFQRMKASKLKGAIVNVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPY 221
Query: 482 GITVNVIAPH 491
GI V +++P+
Sbjct: 222 GIHVQMLSPN 231
>Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 312
Score = 59.7 bits (143), Expect = 2e-08
Identities = 49/185 (26%), Positives = 92/185 (49%), Gaps = 7/185 (3%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVV-INDIRDP-SAVVDEINKKYGSGSAVADTHD 370
G+ ++TGS G+GKS+A+ A++G KVV I+ +D V EI +K+ +
Sbjct: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109
Query: 371 IVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAV----INVHLFSTFAL 426
++ ++T + + ILVNN G+ + + + + V IN+++ S +
Sbjct: 110 ASEDIYDKIKTGLAGL-EIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKM 168
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVN 486
++ V P +++ G I+N +S SG+ Y+A K + FS+ L E +G+ V
Sbjct: 169 TQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQ 228
Query: 487 VIAPH 491
+ P+
Sbjct: 229 SVLPY 233
Score = 58.9 bits (141), Expect = 3e-08
Identities = 46/180 (25%), Positives = 85/180 (46%), Gaps = 5/180 (2%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSDN 70
++TG+ G+G+ YA E AK G KVV+ + D V EIK+ D S++
Sbjct: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113
Query: 71 GAAIVETAISNFGRVDILINNAGILRDSSFAKMS----EKQFQQVIDVHLNGAFKLTRAA 126
++T ++ + IL+NN G+ + + + +++I++++ K+T+
Sbjct: 114 IYDKIKTGLAGL-EIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLV 172
Query: 127 WPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSIAP 186
P M ++ G I+N S +G+ YSA K + F + L +E + V S+ P
Sbjct: 173 LPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLP 232
>CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 368
Score = 59.7 bits (143), Expect = 2e-08
Identities = 48/186 (25%), Positives = 87/186 (45%), Gaps = 8/186 (4%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANY--D 65
R V ITG G GR AL+ ++G V L +S+ E +K G G ++ + D
Sbjct: 70 RAVFITGCDSGFGRGLALKCLEQGMPVFAGCLTEQGIESLSAEARKSIGNGRSLDAFLMD 129
Query: 66 SVSDNG----AAIVETAISNFGRVDILINNAGIL-RDSSFAKMSEKQFQQVIDVHLNGAF 120
SD A +E +G + ++NNAGI + + + ++ +V +++L G
Sbjct: 130 VTSDESVGEVAKRLEKKCEQYGGLHAVVNNAGITGKHIADDFLDINEYLKVANINLWGPI 189
Query: 121 KLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
+ T A ++K + GR++ S G G YS +K G+ + + + +E + I+
Sbjct: 190 RTTMAVKKLLKKAR-GRVVTVASICARVGLPGLGPYSVSKYGVSAYCDVIRQELRPFGIS 248
Query: 181 VNSIAP 186
V+ + P
Sbjct: 249 VHVLEP 254
>SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 296
Score = 59.3 bits (142), Expect = 3e-08
Identities = 68/265 (25%), Positives = 109/265 (40%), Gaps = 37/265 (13%)
Query: 7 DRVVIITGAG-GGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
++ V+ITG GG+G AL++ + G +V+ A V+ + L G D
Sbjct: 4 EKFVLITGCSEGGIGNALALKFHQEGFQVL-------ATARQVERMDNLTKAGLQTLKLD 56
Query: 66 SVSDNGAAIVETAISNF--GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLT 123
++ VE + F G + LINNAG + + + +V+DV+ G ++
Sbjct: 57 VTDEDSVREVEQEVRKFTNGSLHYLINNAGAPCSAPAIDLDIEDVSKVMDVNFYGVIRMN 116
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNS 183
+A + H + G I+N S A Y+A+K LL + +L E + + V S
Sbjct: 117 KA-FQHQLIRAKGTIVNVNSLVSYVPFAFNAAYNASKAALLAYSNTLRIELAPFGVQVTS 175
Query: 184 I-----------APLARSAMTENVIPANIL----KELGPEKIAPLILYLTHENTKVTNNI 228
I PL MTE IP N + ++L E P+ ++T E
Sbjct: 176 IMTGGVQTKIQSKPL--GTMTEAAIPENSIYYPYRKLILENRNPVEKFVTIE-------- 225
Query: 229 FELAAGFYSQIRWERSSGELFHPNV 253
E A Y Q+ +LF P V
Sbjct: 226 -EFADAAYPQLVGRGRWYQLFKPGV 249
>CE02370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 309
Score = 58.9 bits (141), Expect = 3e-08
Identities = 58/202 (28%), Positives = 99/202 (48%), Gaps = 15/202 (7%)
Query: 299 PENKNGPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVI--NDIRDPSAVVDEIN 356
P K+ + + +GK+V++TG G+G+GK+ A FA A VVI + +I
Sbjct: 11 PIRKSPVLRDGAFKGKLVLVTGGGTGIGKAIATTFAHLRATVVIAARRMEKLEQTARDIT 70
Query: 357 KKYGSGSAVADTHDIVKEAQQVVQTAVD----KFGRV-DILVNNAGILRDRSFAKMTEDE 411
K G G+ DI + +V A D KFG+V +ILVNNA + ++ +
Sbjct: 71 KITG-GTCEPFQMDI--KDPGMVSDAFDKIDMKFGKVPEILVNNAAGNFIMATELLSSNA 127
Query: 412 WNAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQ---CNYAAAKAAIL 468
+ +I++ L TF ++ + ++ K+G I TS + Y G A +KA +
Sbjct: 128 YGTIIDIVLKGTFNVTTELGKRCIQNKTGASI--TSITAGYARAGAPFIVPSAVSKAGVE 185
Query: 469 GFSRTLALEGTKRGITVNVIAP 490
+++LA E +K G+ N ++P
Sbjct: 186 TMTKSLATEWSKYGLRFNAVSP 207
Score = 58.5 bits (140), Expect = 4e-08
Identities = 60/252 (23%), Positives = 105/252 (40%), Gaps = 25/252 (9%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANY 64
FK ++V++TG G G+G+ A +A VV+ + ++I K+ G G
Sbjct: 23 FKGKLVLVTGGGTGIGKAIATTFAHLRATVVIAARRMEKLEQTARDITKITG-GTCEPFQ 81
Query: 65 DSVSDNG--AAIVETAISNFGRV-DILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFK 121
+ D G + + FG+V +IL+NNA + +S + +ID+ L G F
Sbjct: 82 MDIKDPGMVSDAFDKIDMKFGKVPEILVNNAAGNFIMATELLSSNAYGTIIDIVLKGTFN 141
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQ---ANYSAAKLGLLGFGESLAKEGYKYN 178
+T + K G I + + Y G + +K G+ +SLA E KY
Sbjct: 142 VTTELGKRCIQNKTGASITSITAG--YARAGAPFIVPSAVSKAGVETMTKSLATEWSKYG 199
Query: 179 INVNSIAP-----------LARSAMTENVIPANILKELG----PEKIAPLILYLTHENTK 223
+ N+++P L M + L G PE++A L+ +++ ++
Sbjct: 200 LRFNAVSPGPIPTKGAWGRLNSGEMGDIAEKMKFLNPEGRVGSPEEVANLVAFISSDHMS 259
Query: 224 VTNN-IFELAAG 234
N I +L G
Sbjct: 260 FLNGAIIDLDGG 271
>YIR036c [Q] KOG1204 Predicted dehydrogenase
Length = 263
Score = 58.5 bits (140), Expect = 4e-08
Identities = 48/197 (24%), Positives = 89/197 (44%), Gaps = 9/197 (4%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIV 372
GKV++ITG+ G+G + + ++ + A + + ++YG+ V DI
Sbjct: 2 GKVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQREYGADKFVYRVLDIT 61
Query: 373 KEA--QQVVQTAVDKFGRVDILVNNAGILR-----DRSFAKMTEDEWNAVINVHLFSTFA 425
+ + +V+ K G++D +V NAG+L +S ++ +W + +V+ FS +
Sbjct: 62 DRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIVS 121
Query: 426 LSKAVWPIFLKQK-SGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
L P+ G I+ +S + + G Y +KAA+ F+ +A E +
Sbjct: 122 LVALCLPLLKSSPFVGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKVR 181
Query: 485 VNVIAPH-AETAMTKTI 500
IAP +T M K I
Sbjct: 182 AVCIAPGVVDTQMQKDI 198
Score = 56.2 bits (134), Expect = 2e-07
Identities = 51/216 (23%), Positives = 94/216 (42%), Gaps = 14/216 (6%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSV 67
+V++ITGA G+G + + +V + R+ A +Q +++ G V +
Sbjct: 3 KVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAG--LQSLQREYGADKFVYRVLDI 60
Query: 68 SDNG--AAIVETAISNFGRVDILINNAGILR-----DSSFAKMSEKQFQQVIDVHLNGAF 120
+D A+VE G++D ++ NAG+L S ++ KQ++++ DV+
Sbjct: 61 TDRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIV 120
Query: 121 KLTRAAWPHMRKQKF-GRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNI 179
L P ++ F G I+ S A + G + Y +K L F +A E +
Sbjct: 121 SLVALCLPLLKSSPFVGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKV 180
Query: 180 NVNSIAPLARSAMTENVIPANILKELGPEKIAPLIL 215
IAP + + + +I + LGP+ + P L
Sbjct: 181 RAVCIAP----GVVDTQMQKDIRETLGPQGMTPKAL 212
>CE21514 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 319
Score = 58.5 bits (140), Expect = 4e-08
Identities = 56/204 (27%), Positives = 87/204 (42%), Gaps = 23/204 (11%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP-------------SAVVDEIN 356
SL G++ I+TG+ G+G+ A GA V I R P A DEI
Sbjct: 2 SLAGQIAIVTGASRGIGRGIALQLGEAGATVYITG-RKPEESLNSKVGLSGLEATADEIT 60
Query: 357 KKYGSGSAVADTHDIVKEAQQVVQTAVDKF-GRVDILVNNA--GIL-----RDRSFAKMT 408
K+ G G A H ++E + + + G++DILVNNA G+ + F +
Sbjct: 61 KRGGKGIARFVDHQNMEEVKNFFEVVEKEHQGQLDILVNNAYQGVTAISENMGKPFYETD 120
Query: 409 EDEWNAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAIL 468
W+ + NV L + + + + + G I+N +S G+ F Y K A+
Sbjct: 121 PYVWDTINNVGLRNHYFCTVYAARLMTARNKGLIVNVSSGGGLRYLFNVA-YGVGKQALD 179
Query: 469 GFSRTLALEGTKRGITVNVIAPHA 492
S A+E K+ + V I P A
Sbjct: 180 RMSADTAVELRKKNVCVVSIWPGA 203
Score = 51.6 bits (122), Expect = 5e-06
Identities = 57/199 (28%), Positives = 88/199 (43%), Gaps = 23/199 (11%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVV----------NDLGRSAADSVVQEIKKLGGE 57
++ I+TGA G+GR AL+ + G V + + +G S ++ EI K GG+
Sbjct: 6 QIAIVTGASRGIGRGIALQLGEAGATVYITGRKPEESLNSKVGLSGLEATADEITKRGGK 65
Query: 58 GDA-VANYDSVSD--NGAAIVETAISNFGRVDILINNA--GILRDSS-----FAKMSEKQ 107
G A ++ ++ + N +VE + G++DIL+NNA G+ S F +
Sbjct: 66 GIARFVDHQNMEEVKNFFEVVEK--EHQGQLDILVNNAYQGVTAISENMGKPFYETDPYV 123
Query: 108 FQQVIDVHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFG 167
+ + +V L + T A M + G I+N S GL F A Y K L
Sbjct: 124 WDTINNVGLRNHYFCTVYAARLMTARNKGLIVNVSSGGGLRYLFNVA-YGVGKQALDRMS 182
Query: 168 ESLAKEGYKYNINVNSIAP 186
A E K N+ V SI P
Sbjct: 183 ADTAVELRKKNVCVVSIWP 201
>SPCC162.03 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 58.2 bits (139), Expect = 6e-08
Identities = 49/177 (27%), Positives = 80/177 (44%), Gaps = 7/177 (3%)
Query: 316 VIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIVKEA 375
V+ITGS GLG + + G V+ R P + E +K V D VK
Sbjct: 8 VLITGSSKGLGYALVKVGLAQGYNVIACS-RAPDTITIEHSKLLKLKLDVTD----VKSV 62
Query: 376 QQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKAVWPIFL 435
+ + A +FG VDI++NNAG F +E + +NV+ + ++K +
Sbjct: 63 ETAFKDAKRRFGNVDIVINNAGYGLVGEFESYNIEEMHRQMNVNFWGVAYITKEALNLMR 122
Query: 436 KQ-KSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE-GTKRGITVNVIAP 490
+ K G I+ +S +G Y + Y A+K A+ G S+T+ E I + ++ P
Sbjct: 123 ESGKGGRILQISSVAGYYPSPCLSMYNASKFAVEGLSQTIMRELDPNWNIAITIVQP 179
Score = 55.5 bits (132), Expect = 4e-07
Identities = 51/179 (28%), Positives = 83/179 (45%), Gaps = 9/179 (5%)
Query: 10 VIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSD 69
V+ITG+ GLG +G V+ A D++ E KL V + SV
Sbjct: 8 VLITGSSKGLGYALVKVGLAQGYNVIACS---RAPDTITIEHSKLLKLKLDVTDVKSVE- 63
Query: 70 NGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAAWPH 129
+ A FG VDI+INNAG F + ++ + ++V+ G +T+ A
Sbjct: 64 ---TAFKDAKRRFGNVDIVINNAGYGLVGEFESYNIEEMHRQMNVNFWGVAYITKEALNL 120
Query: 130 MRKQ-KFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKE-GYKYNINVNSIAP 186
MR+ K GRI+ S AG Y + + Y+A+K + G +++ +E +NI + + P
Sbjct: 121 MRESGKGGRILQISSVAGYYPSPCLSMYNASKFAVEGLSQTIMRELDPNWNIAITIVQP 179
>Hs5031765 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 57.8 bits (138), Expect = 7e-08
Identities = 55/177 (31%), Positives = 78/177 (43%), Gaps = 8/177 (4%)
Query: 10 VIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVSD 69
VI+TGA G+GR A AK G VVV + VV +LG A A+Y + +
Sbjct: 37 VIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGA---ASAHYIAGTM 93
Query: 70 NGAAIVETAISNFGR----VDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRA 125
E ++ G+ +D+LI N + ++ ++V+ LT A
Sbjct: 94 EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153
Query: 126 AWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVN 182
A P M KQ G I+ S AG A YSA+K L GF S+ KE +NV+
Sbjct: 154 ALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVS 209
Score = 53.5 bits (127), Expect = 1e-06
Identities = 51/183 (27%), Positives = 90/183 (48%), Gaps = 10/183 (5%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINK--KYGSGSA--VA 366
L+GK VI+TG+ G+G+ A A+ GA VV+ R + ++ + G+ SA +A
Sbjct: 32 LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVT-ARSKETLQKVVSHCLELGAASAHYIA 90
Query: 367 DTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTED--EWNAVINVHLFSTF 424
T + + A+Q V A G +D+L+ N + + S +D + V+ S
Sbjct: 91 GTMEDMTFAEQFVAQAGKLMGGLDMLILNH--ITNTSLNLFHDDIHHVRKSMEVNFLSYV 148
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
L+ A P+ LKQ +G I+ +S +G Y+A+K A+ GF ++ E + +
Sbjct: 149 VLTVAALPM-LKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVN 207
Query: 485 VNV 487
V++
Sbjct: 208 VSI 210
>Hs10190746 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 336
Score = 57.8 bits (138), Expect = 7e-08
Identities = 54/206 (26%), Positives = 89/206 (42%), Gaps = 29/206 (14%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKK-------------L 54
+ V+ITGA GLGR A E + G +V++ R+ A+ ++++ +
Sbjct: 44 KTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGV 103
Query: 55 GGEGDAVANYDSVSD--NGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVI 112
G G+ + ++ + A + + R+D+LINNAGI + + K +E F+
Sbjct: 104 SGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQ-CPYMK-TEDGFEMQF 161
Query: 113 DVHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYG--NFGQAN----------YSAAK 160
V+ G F LT ++ RI+ S YG NF N YS +K
Sbjct: 162 GVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSK 221
Query: 161 LGLLGFGESLAKEGYKYNINVNSIAP 186
L + F LA+ N+ VN + P
Sbjct: 222 LANILFTRELARRLEGTNVTVNVLHP 247
Score = 57.4 bits (137), Expect = 1e-07
Identities = 57/211 (27%), Positives = 93/211 (44%), Gaps = 35/211 (16%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVI--NDIRDPSAVVDEINKKY--------- 359
+ GK V+ITG+ SGLG++ A R GA+V++ D ++ ++
Sbjct: 41 MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPE 100
Query: 360 ----GSGSAVADTHDI--VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWN 413
G G + D+ ++ + Q + + R+D+L+NNAGI + TED +
Sbjct: 101 PGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYM--KTEDGFE 158
Query: 414 AVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYG--NFGQCN----------YA 461
V+ F L+ + + I+ +S YG NF N Y+
Sbjct: 159 MQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYS 218
Query: 462 AAKAAILGFSRTLA--LEGTKRGITVNVIAP 490
+K A + F+R LA LEGT +TVNV+ P
Sbjct: 219 RSKLANILFTRELARRLEGT--NVTVNVLHP 247
>7300387 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 57.8 bits (138), Expect = 7e-08
Identities = 54/197 (27%), Positives = 92/197 (46%), Gaps = 19/197 (9%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVI--NDIRDPSAVVDEINKKYGSGSAVADT 368
+ GK VIITG+ SG+GK A+ A GA++++ ++ +AV DEI K+ + +
Sbjct: 31 MEGKTVIITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKETKNNKILVKK 90
Query: 369 HDI--VKEAQQVVQTAVDKFGRVDILVNNAGIL--------RDRSFAKMTEDEWNAVINV 418
D+ K ++ V ++D+L++NAG+ D M + + +
Sbjct: 91 LDLGSQKSVREFAADIVKTEPKIDVLIHNAGMALAFRGQTSEDGVELTMATNHYGPFLLT 150
Query: 419 HLFSTFALSKAVWPIFLKQKSGYIINTTSTSGI--YGNFGQCN-YAAAKAAILGFSRTLA 475
HL A I + Y +++ + + + G F Y +K A + F+R LA
Sbjct: 151 HLLIDVLKKSAPARIVIVASELYRLSSVNLAKLNPIGTFPAAYLYYVSKFANIYFARELA 210
Query: 476 --LEGTKRGITVNVIAP 490
LEGTK +TVN + P
Sbjct: 211 KRLEGTK--VTVNFLHP 225
>Hs7705925 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 244
Score = 57.4 bits (137), Expect = 1e-07
Identities = 47/182 (25%), Positives = 85/182 (45%), Gaps = 9/182 (4%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKY-GSGSAVADTH 369
L G+ V++TG+G G+G+ Q GA+VV + A +D + ++ G D
Sbjct: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVA--VSRTQADLDSLVRECPGIEPVCVDLG 62
Query: 370 DIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFALSKA 429
D + + A+ G VD+LVNNA + + F ++T++ ++ V+L + +S+
Sbjct: 63 D-----WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117
Query: 430 V-WPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITVNVI 488
V + + G I+N +S Y + K A+ ++ +ALE I VN +
Sbjct: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177
Query: 489 AP 490
P
Sbjct: 178 NP 179
Score = 54.3 bits (129), Expect = 8e-07
Identities = 45/187 (24%), Positives = 86/187 (45%), Gaps = 9/187 (4%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDA 60
M L R V++TGAG G+GR G +VV ++ DS+V+E +
Sbjct: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60
Query: 61 VANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
+ ++++ E A+ + G VD+L+NNA + F +++++ F + +V+L
Sbjct: 61 LGDWEAT--------ERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVI 112
Query: 121 KLTR-AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNI 179
++++ A + + G I+N S + Y + K L + +A E + I
Sbjct: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172
Query: 180 NVNSIAP 186
VN++ P
Sbjct: 173 RVNAVNP 179
>Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 57.0 bits (136), Expect = 1e-07
Identities = 53/183 (28%), Positives = 88/183 (47%), Gaps = 6/183 (3%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSV-VQEIKKLGGEGDAVANY 64
+D+ V ITG G G++ A + RG +V+ L A+ + Q +L V
Sbjct: 28 RDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKT 87
Query: 65 DSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQ-FQQVIDVHLNGAFKLT 123
+SV+ A V+ + + G L+NNAGI ++ ++ KQ ++DV+L G +T
Sbjct: 88 ESVA-AAAQWVKECVRDKGLWG-LVNNAGISLPTAPNELLTKQDLLTILDVNLLGVIDVT 145
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNS 183
P +R+ + GR++N S G FG Y +K G+ F +SL +E + + V
Sbjct: 146 LNLLPLVRRAR-GRVVNVFSVMGRVSLFG-GGYCISKYGVEAFSDSLRRELSYFGVKVAM 203
Query: 184 IAP 186
I P
Sbjct: 204 IEP 206
>Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 309
Score = 57.0 bits (136), Expect = 1e-07
Identities = 52/193 (26%), Positives = 92/193 (46%), Gaps = 26/193 (13%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVI------------NDIRDPSAV-VDEINKKY 359
G+ +++G+ G+GK++A+ A G +++ DI D V D I +
Sbjct: 46 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADF 105
Query: 360 GSGSAVADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRD--RSFAKMTEDEWNAVIN 417
SG + + ++EA + DK V ILVNN G+ + F +++ED+ +IN
Sbjct: 106 SSGREI---YLPIREALK------DK--DVGILVNNVGVFYPYPQYFTQLSEDKLWDIIN 154
Query: 418 VHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
V++ + + V P +++K G I+ +S S ++A+KA + FSR L E
Sbjct: 155 VNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYE 214
Query: 478 GTKRGITVNVIAP 490
+GI V + P
Sbjct: 215 YASKGIFVQSLIP 227
Score = 52.8 bits (125), Expect = 2e-06
Identities = 54/199 (27%), Positives = 87/199 (43%), Gaps = 8/199 (4%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEI-KKLGGEGD-AVANYD 65
R +++GA G+G+ YA E A RG +++ V ++I E D VA++
Sbjct: 47 RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFS 106
Query: 66 SVSDNGAAIVETAISNFGRVDILINNAGIL--RDSSFAKMSEKQFQQVIDVHLNGAFKLT 123
S + I E V IL+NN G+ F ++SE + +I+V++ A +
Sbjct: 107 SGREIYLPIREALKDK--DVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMV 164
Query: 124 RAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNS 183
P M ++K G I+ S + A +SA+K L F +L E I V S
Sbjct: 165 HVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQS 224
Query: 184 IAPLARSAMTENVIPANIL 202
+ P +A P+N L
Sbjct: 225 LIPFYVAA--SMTAPSNFL 241
>CE11498 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 323
Score = 57.0 bits (136), Expect = 1e-07
Identities = 53/204 (25%), Positives = 90/204 (43%), Gaps = 19/204 (9%)
Query: 1 MSLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVND----------LGRSAADSVVQE 50
M + +D+V ++TGA G+GR AL+ + G V + LG + D V +E
Sbjct: 1 MGVILQDQVALVTGASRGIGRGIALQLGEAGATVYITGRRPELSDNFRLGLPSLDYVAKE 60
Query: 51 IKKLGGEGDAV-ANYDSVSDNGAAIVETAISNFGRVDILINN-------AGILRDSSFAK 102
I GG+G A+ ++ ++++ + G++DIL+NN A + +F
Sbjct: 61 ITSRGGKGIALYVDHSNMTEVKFLFEKIKEDEEGKLDILVNNVYNSLGKATEMIGKTFFD 120
Query: 103 MSEKQFQQVIDVHLNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLG 162
+ + V L + + A M +++ G I+N S GL F A Y A K
Sbjct: 121 QDPSFWDDINGVGLRNHYYCSVYAARMMVERRKGLIVNVGSLGGLKYVFNVA-YGAGKEA 179
Query: 163 LLGFGESLAKEGYKYNINVNSIAP 186
L +A E YN+ V ++ P
Sbjct: 180 LARMSTDMAVELNPYNVCVVTLIP 203
Score = 52.8 bits (125), Expect = 2e-06
Identities = 51/200 (25%), Positives = 86/200 (42%), Gaps = 21/200 (10%)
Query: 311 LRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRD----------PSA--VVDEINKK 358
L+ +V ++TG+ G+G+ A GA V I R PS V EI +
Sbjct: 5 LQDQVALVTGASRGIGRGIALQLGEAGATVYITGRRPELSDNFRLGLPSLDYVAKEITSR 64
Query: 359 YGSGSAVADTHDIVKEAQQVVQ-TAVDKFGRVDILVNN-------AGILRDRSFAKMTED 410
G G A+ H + E + + + D+ G++DILVNN A + ++F
Sbjct: 65 GGKGIALYVDHSNMTEVKFLFEKIKEDEEGKLDILVNNVYNSLGKATEMIGKTFFDQDPS 124
Query: 411 EWNAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGF 470
W+ + V L + + S + ++++ G I+N S G+ F Y A K A+
Sbjct: 125 FWDDINGVGLRNHYYCSVYAARMMVERRKGLIVNVGSLGGLKYVFNVA-YGAGKEALARM 183
Query: 471 SRTLALEGTKRGITVNVIAP 490
S +A+E + V + P
Sbjct: 184 STDMAVELNPYNVCVVTLIP 203
>7292613 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 57.0 bits (136), Expect = 1e-07
Identities = 62/231 (26%), Positives = 101/231 (42%), Gaps = 25/231 (10%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGE--GDAVA 62
+++RV ++TGA G+G A + G VV L R D V + ++L E G A
Sbjct: 4 WQNRVAVVTGASSGIGSAIAKDLVLAGMTVV--GLARRV-DRVKELQRELPAEKRGKLFA 60
Query: 63 NYDSVSDNGAA--IVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAF 120
Y V + + + I G +D+L+NNAG L+ M+ QQV+ ++ G
Sbjct: 61 LYCDVGNESSVNEAFDWIIQKLGAIDVLVNNAGTLQPGYLVDMNPAVMQQVLQTNIMGIV 120
Query: 121 KLTRAAWPHMRKQKF-GRIINTCSPAG---LYGNFGQAN----YSAAKLGLLGFGESLAK 172
T+ A MR++KF G ++ S G + G A Y +K + E +
Sbjct: 121 LCTQRAVRSMRERKFDGHVVLINSILGHKTMTATEGVAPDVNVYPPSKHAVTALAEGYRQ 180
Query: 173 E--GYKYNINVNSIAPLARSAMTENVIPANIL-----KELGPEKIAPLILY 216
E G I + S++P + ++P +I + L E IA +LY
Sbjct: 181 EFFGLGTRIKITSVSP---GVVDTEIVPDSIREAIKDRMLHSEDIAQGVLY 228
>7295621 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 56.6 bits (135), Expect = 2e-07
Identities = 59/223 (26%), Positives = 96/223 (42%), Gaps = 18/223 (8%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYDSVS 68
V ++TGA G+G + G VV + + +E+ + + D VS
Sbjct: 8 VAVVTGASSGIGAAITRKLISAGVMVVALARRMDRLEQLREELPQDRRSRLRIMQCD-VS 66
Query: 69 DNGA--AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRAA 126
D + A+ + + G VDILINNAG L MS QQ++ ++ G T+ A
Sbjct: 67 DVSSVNAVFDAVQGDLGNVDILINNAGKLSGGQLLTMSVDTVQQMLQTNVMGVVYCTQRA 126
Query: 127 WPHMR-KQKFGRIINTCSPAGLY------GNFGQAN-YSAAKLGLLGFGESLAKE--GYK 176
+ MR +Q G ++ S G Y G+ + N Y A K + E +E +K
Sbjct: 127 FESMRQRQSKGHVVLINSIVGHYIFNPLPGSQQELNMYPATKHAITALTELFRQEMRDFK 186
Query: 177 YNINVNSIAPLARSAMTENVIPANI--LKELGPEKIAPLILYL 217
+ V SI+P + ++P + L L E +A I+Y+
Sbjct: 187 TKVKVTSISP---GLVDTELVPLDYKGLPMLQAEDVANAIMYV 226
>CE07539 [Q] KOG1205 Predicted dehydrogenase
Length = 537
Score = 56.2 bits (134), Expect = 2e-07
Identities = 49/184 (26%), Positives = 84/184 (45%), Gaps = 10/184 (5%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKK---LGGEGD 59
L K+++V+ITGA GLG+ A E KRG +V++ + E+ K L
Sbjct: 74 LNVKNKIVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICAELTKTFPLNKNKP 133
Query: 60 AVANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGA 119
+D + + A + +VD+LINNAG+ S + ++ ++ +L G
Sbjct: 134 TYYFFDITNPDKAPWAQ-----IPKVDVLINNAGMSNRGSCQDTTMAIHRKAMETNLFGH 188
Query: 120 FKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNI 179
++T++ + G I+ T S G + +YSA+K L G+ + L E +I
Sbjct: 189 VQVTQSLLSKLSPD--GCIVVTSSIQGKVAIPYRGSYSASKHALQGYFDCLRAEHKNLHI 246
Query: 180 NVNS 183
V S
Sbjct: 247 LVVS 250
>SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 55.8 bits (133), Expect = 3e-07
Identities = 52/186 (27%), Positives = 81/186 (42%), Gaps = 12/186 (6%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVD--EINKKYGSGSAV---ADT 368
KV I G G+G S + + V R P A + E +K + + V +
Sbjct: 6 KVYFIAGGNRGIGLSLVKELSSREGTTVFASARKPEAATELQEWSKSHPNVKTVELDVTS 65
Query: 369 HDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDR-SFAKMTEDEWNAVINVHLFSTFALS 427
EA Q V AVD +D+L N+GI + + + E+ WNA ++ +
Sbjct: 66 QQSANEAAQSVAKAVDG---IDVLWLNSGICQSYYTVMEAPEEVWNAHYQTNVLGPIHVF 122
Query: 428 KAVWPIFLKQKSGYIINTTSTSGIYGNF---GQCNYAAAKAAILGFSRTLALEGTKRGIT 484
KA +P+ K+K+ +I T+S G G+F G Y +KAAI + L++E T
Sbjct: 123 KAFYPLLTKKKTRQVIFTSSECGSMGDFRATGFSAYGQSKAAINFTMKELSVELADEHFT 182
Query: 485 VNVIAP 490
I P
Sbjct: 183 FISIHP 188
>SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase
Length = 247
Score = 55.8 bits (133), Expect = 3e-07
Identities = 46/168 (27%), Positives = 84/168 (49%), Gaps = 21/168 (12%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVAN 63
E ++V+++TG+ G+G A E ++ KV+ + + S+ E++ L + N
Sbjct: 3 ETAEKVILLTGSSKGIGLATA-EALQKKAKVI------AVSRSLTPELETL-----LIQN 50
Query: 64 YDS-------VSDNGAAIVETAISNFGRVDILINNAGILRD-SSFAKMSEKQFQQVIDVH 115
DS V++ G A +ETAI FG++D +I NAG+L + A +++++ D++
Sbjct: 51 PDSFVHVKGDVTEVGKASIETAIKKFGKLDSVILNAGVLEPIAKIADADINEWRKLFDIN 110
Query: 116 LNGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGL 163
+ + A PH+RK K G I+ S A + A Y +K +
Sbjct: 111 FFSVVETVKYAIPHLRKTK-GTIVIVSSGAAVRVFPAWAAYCCSKAAI 157
Score = 54.3 bits (129), Expect = 8e-07
Identities = 39/155 (25%), Positives = 72/155 (46%), Gaps = 5/155 (3%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDIVK 373
KV+++TGS G+G + A+ + + ++ P I S V D+ +
Sbjct: 7 KVILLTGSSKGIGLATAEALQKKAKVIAVSRSLTPELETLLIQNP---DSFVHVKGDVTE 63
Query: 374 EAQQVVQTAVDKFGRVDILVNNAGILRD-RSFAKMTEDEWNAVINVHLFSTFALSKAVWP 432
+ ++TA+ KFG++D ++ NAG+L A +EW + +++ FS K P
Sbjct: 64 VGKASIETAIKKFGKLDSVILNAGVLEPIAKIADADINEWRKLFDINFFSVVETVKYAIP 123
Query: 433 IFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAI 467
L++ G I+ +S + + Y +KAAI
Sbjct: 124 -HLRKTKGTIVIVSSGAAVRVFPAWAAYCCSKAAI 157
>Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 318
Score = 55.8 bits (133), Expect = 3e-07
Identities = 53/187 (28%), Positives = 85/187 (45%), Gaps = 6/187 (3%)
Query: 2 SLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAV 61
SL + V ITG G GR+ AL+ ++ +V+ + L S A+ +Q + G +
Sbjct: 23 SLPASNAFVFITGCDSGFGRLLALQLDQKSFRVLASCLTPSGAED-LQGVASSGFNTTLL 81
Query: 62 ANYDSVS-DNGAAIVETAISNFGRVDILINNAGILR-DSSFAKMSEKQFQQVIDVHLNGA 119
D S A VE + G L+NNAG+ ++ FQ+V++V+ G
Sbjct: 82 DITDPQSFQQAAKWVEMHVKEAGLFG-LVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGP 140
Query: 120 FKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNI 179
+T A P + +Q GR+IN S G G Y +K GL F +SL ++ + I
Sbjct: 141 IGVTLALLP-LLQQARGRVINITSVLGRLAANG-GGYCVSKFGLEAFSDSLRRDVAHFGI 198
Query: 180 NVNSIAP 186
+ + P
Sbjct: 199 RESIVEP 205
>Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 387
Score = 55.1 bits (131), Expect = 5e-07
Identities = 50/185 (27%), Positives = 84/185 (45%), Gaps = 13/185 (7%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDI-- 371
K V++TG GLG + ++ G V + + +E+ + +V DI
Sbjct: 83 KAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQM-DITK 141
Query: 372 ---VKEAQQVVQTAVDKFGRVDILVNNAGIL---RDRSFAKMTEDEWNAVINVHLFSTFA 425
+K+A V + G + ++NNAG+L D MT ++ + V+ F T
Sbjct: 142 PVQIKDAYSKVAAMLQDRG-LWAVINNAGVLGFPTDGELLLMT--DYKQCMAVNFFGTVE 198
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGITV 485
++K P+ K K G ++N +S G +Y ++KAA+ FS + LE +K GI V
Sbjct: 199 VTKTFLPLLRKSK-GRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKV 257
Query: 486 NVIAP 490
I P
Sbjct: 258 ASIQP 262
>Hs20070272 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 318
Score = 55.1 bits (131), Expect = 5e-07
Identities = 50/199 (25%), Positives = 92/199 (46%), Gaps = 16/199 (8%)
Query: 2 SLEFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAV 61
+++ +VV++TGA G+G+ A E A+RG +V + + V +EI+ G +
Sbjct: 36 TVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVL 95
Query: 62 ANYDSVSDNGA--AIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGA 119
+SD + A + ++ + +LINNAG++ ++K ++ F+ I V+ G
Sbjct: 96 VRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMM-CPYSKTAD-GFEMHIGVNHLGH 153
Query: 120 FKLTRAAWPHMRKQKFGRIINTCSPAGLYGNF------GQANYSA------AKLGLLGFG 167
F LT +++ RI+N S A G G+ Y+A +KL + F
Sbjct: 154 FLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFT 213
Query: 168 ESLAKEGYKYNINVNSIAP 186
+ LA+ + S+ P
Sbjct: 214 QELARRLKGSGVTTYSVHP 232
>Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 319
Score = 55.1 bits (131), Expect = 5e-07
Identities = 50/194 (25%), Positives = 90/194 (45%), Gaps = 10/194 (5%)
Query: 302 KNGPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGS 361
+ G + I+ + K + ITG SG G A+ F + G V+ + + + +
Sbjct: 18 RKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERL 77
Query: 362 GSAVADTHD--IVKEAQQVVQTAVDKFGRVDILVNNA---GILRDRSFAKMTEDEWNAVI 416
+ + D D VK Q V+ V + G L+NNA G+L + +T +++ I
Sbjct: 78 RTVLLDVTDPENVKRTAQWVKNQVGEKGLWG-LINNAGVPGVLAPTDW--LTLEDYREPI 134
Query: 417 NVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLAL 476
V+LF +++ + P+ +K+ G +IN +S G G Y +K A+ GF+ +L
Sbjct: 135 EVNLFGLISVTLNMLPL-VKKAQGRVINVSSVGGRLAIVGG-GYTPSKYAVEGFNDSLRR 192
Query: 477 EGTKRGITVNVIAP 490
+ G+ V+ I P
Sbjct: 193 DMKAFGVHVSCIEP 206
Score = 52.4 bits (124), Expect = 3e-06
Identities = 49/187 (26%), Positives = 91/187 (48%), Gaps = 10/187 (5%)
Query: 4 EFKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEI-KKLGGEGDAVA 62
+ D+ + ITG G G + A + K+G V+ L S + ++ E ++L V
Sbjct: 26 DITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVT 85
Query: 63 NYDSVSDNGAAIVETAISNFGRVDILINNA---GILRDSSFAKMSEKQFQQVIDVHLNGA 119
+ ++V A V+ + G LINNA G+L + + + + +++ I+V+L G
Sbjct: 86 DPENVK-RTAQWVKNQVGEKGLWG-LINNAGVPGVLAPTDWLTLED--YREPIEVNLFGL 141
Query: 120 FKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNI 179
+T P ++K + GR+IN S G G Y+ +K + GF +SL ++ + +
Sbjct: 142 ISVTLNMLPLVKKAQ-GRVINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMKAFGV 199
Query: 180 NVNSIAP 186
+V+ I P
Sbjct: 200 HVSCIEP 206
>CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 333
Score = 55.1 bits (131), Expect = 5e-07
Identities = 56/219 (25%), Positives = 92/219 (41%), Gaps = 17/219 (7%)
Query: 305 PIPIKSLRGKV-VIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINK----KY 359
PI +K G ++TG+ G+GK++A AR G V++ + + +DE K KY
Sbjct: 55 PIDLKKRAGASWAVVTGATDGIGKAYAFELARRGFNVLL--VSRTQSKLDETKKEILEKY 112
Query: 360 GSGSAVADTHDIVKEAQQVVQTAVDKFGRVDI--LVNNAGILRD-RSFAKMTEDEWNAVI 416
S D A + + +V+I L+NN G+ + + +
Sbjct: 113 SSIEVRTAAFDFTNAAPSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIERLA 172
Query: 417 NVHLFSTF---ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRT 473
N+ +T LS + P + +K+G I+N S++G Y+A K + +
Sbjct: 173 NITTINTLPPTLLSAGILPQMVARKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAI 232
Query: 474 LALEGTKRGITVNVIAPHAETAMTKTIFSSKELNNHFDP 512
L E +GITV IAP M T S + + F P
Sbjct: 233 LRKEYEHQGITVQTIAP----MMVATKMSKVKRTSFFTP 267
Score = 51.6 bits (122), Expect = 5e-06
Identities = 51/183 (27%), Positives = 81/183 (43%), Gaps = 6/183 (3%)
Query: 11 IITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEI-KKLGGEGDAVANYDSVSD 69
++TGA G+G+ YA E A+RG V++ +S D +EI +K A +D +
Sbjct: 68 VVTGATDGIGKAYAFELARRGFNVLLVSRTQSKLDETKKEILEKYSSIEVRTAAFDFTNA 127
Query: 70 NGAAIVE-TAISNFGRVDILINNAGILRD--SSFAKMSE--KQFQQVIDVHLNGAFKLTR 124
+A + A N + +LINN G+ + K+ ++ + ++ L+
Sbjct: 128 APSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIERLANITTINTLPPTLLSA 187
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSI 184
P M +K G I+N S AG A YSA K + L KE I V +I
Sbjct: 188 GILPQMVARKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRKEYEHQGITVQTI 247
Query: 185 APL 187
AP+
Sbjct: 248 APM 250
>Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase
Length = 244
Score = 55.1 bits (131), Expect = 5e-07
Identities = 55/218 (25%), Positives = 90/218 (41%), Gaps = 7/218 (3%)
Query: 9 VVIITGAGGGLGRVYALEYAK---RGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
VV+ITG G+G A+ A + KV + + + L ++
Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64
Query: 66 -SVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTR 124
V D+ + GRVD+L+ NAG+ + E V+DV++ G ++ +
Sbjct: 65 LDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQ 124
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSI 184
A P M+++ GR++ T S GL G Y A+K L G ESLA + ++++ I
Sbjct: 125 AFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLI 184
Query: 185 -APLARSAMTENVI--PANILKELGPEKIAPLILYLTH 219
+A E V+ P +L YL H
Sbjct: 185 ECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAH 222
>7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 335
Score = 54.7 bits (130), Expect = 6e-07
Identities = 50/189 (26%), Positives = 82/189 (42%), Gaps = 13/189 (6%)
Query: 9 VVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANY---- 64
VV+ITG GLG A+ Y + V + + ++ L D ++
Sbjct: 28 VVLITGCDSGLGHSMAV-YCHESLHMTVISCCHNIKSEGAKLLQGLASAKDGLSRMHTLE 86
Query: 65 -DSVSDNGAAIVETAISNF------GRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLN 117
D + + +V + + R+ LINNAG++ F +Q + I+ +L
Sbjct: 87 LDLLEPDSIRLVHRQLRDILAKDPSYRLTALINNAGVMCFGEFEWQLTEQIEAQINCNLL 146
Query: 118 GAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKY 177
G +LT P +R+Q+ GRIIN S GL Y+A+K L + +SL E +Y
Sbjct: 147 GTMRLTHELLPLLRQQQ-GRIINVTSHCGLQALPALGPYAASKAALRFWTDSLRVELQQY 205
Query: 178 NINVNSIAP 186
+ V + P
Sbjct: 206 GMEVVNFIP 214
Score = 53.5 bits (127), Expect = 1e-06
Identities = 53/183 (28%), Positives = 88/183 (47%), Gaps = 13/183 (7%)
Query: 315 VVIITGSGSGLGKSHAQWFARYGAKVVIN---DIRDPSAVV--------DEINKKYGSGS 363
VV+ITG SGLG S A + VI+ +I+ A + D +++ +
Sbjct: 28 VVLITGCDSGLGHSMAVYCHESLHMTVISCCHNIKSEGAKLLQGLASAKDGLSRMHTLEL 87
Query: 364 AVADTHDIVKEAQQVVQT-AVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFS 422
+ + I +Q+ A D R+ L+NNAG++ F ++ A IN +L
Sbjct: 88 DLLEPDSIRLVHRQLRDILAKDPSYRLTALINNAGVMCFGEFEWQLTEQIEAQINCNLLG 147
Query: 423 TFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
T L+ + P+ L+Q+ G IIN TS G+ YAA+KAA+ ++ +L +E + G
Sbjct: 148 TMRLTHELLPL-LRQQQGRIINVTSHCGLQALPALGPYAASKAALRFWTDSLRVELQQYG 206
Query: 483 ITV 485
+ V
Sbjct: 207 MEV 209
>ECU08g1150 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 296
Score = 54.3 bits (129), Expect = 8e-07
Identities = 51/181 (28%), Positives = 84/181 (46%), Gaps = 18/181 (9%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANYD 65
+ + V+I GA G +GR A ++A++G KV++ S + I+++ + +Y
Sbjct: 39 RKKYVVINGATGKIGRGLAKKFAEKGMKVLLVGRSESRLIRLHAAIERMTECHMHIVDYK 98
Query: 66 SVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFKLTRA 125
N + ++ V ILIN A + DS A E+ +++++V+L G LTR
Sbjct: 99 R--SNNLSFIDRY-----DVGILINCASTMEDSP-AYFVEQSIEEIMNVNLVGVMSLTRY 150
Query: 126 AWPHMRKQKFGRIINTCSPAG-----LYGNFGQANYSAAKLGLLGFGESLAKEGYKYNIN 180
+M +G +IN S G LY FG +K L +SL E YN+N
Sbjct: 151 VLVNMMDCGYGYVINIGSLMGEASTPLYSAFG-----CSKQALKALSDSLYYELEGYNVN 205
Query: 181 V 181
V
Sbjct: 206 V 206
>YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 326
Score = 53.9 bits (128), Expect = 1e-06
Identities = 48/188 (25%), Positives = 86/188 (45%), Gaps = 12/188 (6%)
Query: 302 KNGPIPIKSLR---GKVVIITGSGSGLGKSH-AQWFARYGAKVVINDIRDPSAVVDEINK 357
++G + KSLR +V+ITG GLG++ +Q Y ++N PS+V + K
Sbjct: 56 RSGQVAWKSLREFKNGIVLITGGSKGLGRAIVSQLLQDYSNLTILNVDICPSSVRNTRVK 115
Query: 358 KYGSGSAVADTHDIVKEAQQVVQTAVDKF-GRVDILVNNAGILRD-RSFAKMTEDEWNAV 415
+ D D +E ++ K+ + ++VNNAG+ + F M D + +
Sbjct: 116 -----DLICDLSDD-EEVAALLNLLKRKYKNEIRLIVNNAGVRANFTGFNGMERDNLDKI 169
Query: 416 INVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLA 475
++ F+ + + P + YI+N S GI YAA+KAA++ F ++ +
Sbjct: 170 FKINTFAPLQFIQELAPSRHSTRQCYIVNIASILGILTPAKVAAYAASKAALIAFHQSYS 229
Query: 476 LEGTKRGI 483
E G+
Sbjct: 230 FELQNEGV 237
>7304181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 331
Score = 53.9 bits (128), Expect = 1e-06
Identities = 62/226 (27%), Positives = 101/226 (44%), Gaps = 30/226 (13%)
Query: 313 GKVVIITGSGSGLGKSHAQWFARYGAKVVI--NDIRDPSAVVDEINKKYGSGSAVADTHD 370
GKV I+TG+ +G+GK + A+ G V + +++ +EI + + D
Sbjct: 45 GKVFIVTGANTGIGKETVREIAKRGGTVYMACRNLKKCEEAREEIVLETKNKYVYCRQCD 104
Query: 371 IVKEAQQVVQTAVDKFGR----VDILVNNAGILR-DRSFAKMTEDEWNAVINVHLFSTFA 425
+ +Q+ ++ V F R + +L+NNAG++R RS +T D + V+ F
Sbjct: 105 LA--SQESIRHFVAAFKREQEHLHVLINNAGVMRCPRS---LTSDGIELQLGVNHMGHFL 159
Query: 426 LSKAVWPIFLKQKSGYIINTTSTSGIYG--NFGQCN----------YAAAKAAILGFSRT 473
L+ + + K I+N +S + G N G N Y+ +K A + F+R
Sbjct: 160 LTNLLLDLLKKSSPSRIVNVSSLAHTRGEINTGDLNSDKSYDEGKAYSQSKLANVLFTRE 219
Query: 474 LA--LEGTKRGITVNVIAPHAETAMTKTIFSSKELNNHFDPGFVSP 517
LA LEGT +T N + H T+ I NN F FV P
Sbjct: 220 LAKRLEGT--NVTANAL--HPGVVDTEIIRHMGFFNNFFAGLFVKP 261
Score = 52.4 bits (124), Expect = 3e-06
Identities = 57/217 (26%), Positives = 90/217 (41%), Gaps = 32/217 (14%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEI------KKLGGEGDAV 61
+V I+TGA G+G+ E AKRGG V + + +EI K + +
Sbjct: 46 KVFIVTGANTGIGKETVREIAKRGGTVYMACRNLKKCEEAREEIVLETKNKYVYCRQCDL 105
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFK 121
A+ +S+ AA + +LINNAG++R ++ + + V+ G F
Sbjct: 106 ASQESIRHFVAAFKREQ----EHLHVLINNAGVMRCP--RSLTSDGIELQLGVNHMGHFL 159
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYG--NFGQAN----------YSAAKLGLLGFGES 169
LT ++K RI+N S A G N G N YS +KL + F
Sbjct: 160 LTNLLLDLLKKSSPSRIVNVSSLAHTRGEINTGDLNSDKSYDEGKAYSQSKLANVLFTRE 219
Query: 170 LAKEGYKYNINVNSIAPLARSAMTENVIPANILKELG 206
LAK N+ N++ P V+ I++ +G
Sbjct: 220 LAKRLEGTNVTANALHP--------GVVDTEIIRHMG 248
>At1g01800 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 309
Score = 53.5 bits (127), Expect = 1e-06
Identities = 46/184 (25%), Positives = 83/184 (45%), Gaps = 12/184 (6%)
Query: 5 FKDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIKKLGGEGDAVANY 64
F RV ++TG+ G+G + A G VV+ + + VQ++K G D ++
Sbjct: 32 FVSRVAVVTGSNKGIGFEICRQLANNGITVVLTARDENKGLAAVQKLKTENGFSDQAISF 91
Query: 65 D----SVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVID----VHL 116
S D A++ + FG++DIL+NNAG+ + + + Q ++++ +
Sbjct: 92 HPLDVSNPDTIASLAAFVKTRFGKLDILVNNAGVGGANVNVDVLKAQIAEIVEECVKTNY 151
Query: 117 NGAFKLTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYK 176
G ++ A P ++ RI++ S G N + AK G+L E+L +E
Sbjct: 152 YGVKRMCEAMIPLLQSSDSPRIVSIASTMGKLEN---VSNEWAK-GVLSDAENLTEEKID 207
Query: 177 YNIN 180
IN
Sbjct: 208 EVIN 211
>SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 52.8 bits (125), Expect = 2e-06
Identities = 48/206 (23%), Positives = 84/206 (40%), Gaps = 10/206 (4%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAV--VDEINKKYGSGSAVAD 367
S K+ I G G+G S + + VV R P A + E +K + + +
Sbjct: 2 STTNKIYFIAGGNRGIGLSLVKELSNRKGTVVFASARKPGAATKLQEWSKSHSNVHIIKL 61
Query: 368 THDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDE-WNAVINVHLFSTFAL 426
++ A + Q VD+L N+ + T D+ WN+ ++ +
Sbjct: 62 DVSSLESANEAAQEVTKVVDAVDVLWVNSAVFHSFGPVVNTPDDVWNSHYKTNVLGPIHV 121
Query: 427 SKAVWPIFLKQKSGYIINTTSTSGIYGNF---GQCNYAAAKAAILGFSRTLALEGTKRGI 483
+A +P+ K +S I+ T+S +G G F Q Y +KAA+ + ++ E G
Sbjct: 122 YQAFYPLIKKGRSKIIVFTSSLAGSMGAFFPSSQSAYGQSKAALNYTMKEISFELQDEGF 181
Query: 484 TVNVIAPHAETAMTKTIFSSKELNNH 509
V I P A +T + + +N H
Sbjct: 182 IVISIHPGA----VRTDSAQEIVNQH 203
>SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 341
Score = 52.8 bits (125), Expect = 2e-06
Identities = 48/189 (25%), Positives = 87/189 (45%), Gaps = 18/189 (9%)
Query: 312 RGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVADTHDI 371
+G ++TG+ G+GK +A A G VV+ I +D + K+ + + V T I
Sbjct: 56 KGYWAVVTGATDGIGKEYATQLAMSGFNVVL--ISRTQEKLDALAKELETVAKVK-TRTI 112
Query: 372 VKEAQQVVQTAVDKFGR------VDILVNNAGILR--DRSFAKMTEDEWNAVINVHLFST 423
+ + +K + + +L+NN G SFA+ T E + +++++ F T
Sbjct: 113 AIDYTKTTAETFEKLHQDLVGTPITVLINNVGQSHYMPTSFAETTVKEMDDIMHINCFGT 172
Query: 424 FALSKAVWPIFLKQKSG-------YIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLAL 476
+KAV I L+++ I+ S +G+ + YA +KA + +S +L
Sbjct: 173 LHTTKAVLSIMLRERQKNEKGPRCLILTMGSFAGLLPSPYLSTYAGSKAFLSNWSASLGE 232
Query: 477 EGTKRGITV 485
E K+GI V
Sbjct: 233 EVKKQGIDV 241
>CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 52.8 bits (125), Expect = 2e-06
Identities = 56/207 (27%), Positives = 85/207 (41%), Gaps = 9/207 (4%)
Query: 305 PIPIKSLRGKV-VIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVV---DEINKKYG 360
PI +K G ++TG+ G+G+S+A AR G + + R S +V +I KY
Sbjct: 44 PIDLKRTAGASWAVVTGATDGIGRSYALDLARRGFNIFLIS-RTKSKLVKTKKQILNKYS 102
Query: 361 SGSAVADTHDIVKEAQQVVQTAVDKFGRVD--ILVNNAGILRDR-SFAKMTEDEWNAVIN 417
D + + + + + VD IL+NN G+ D E + + N
Sbjct: 103 DIEVRYAICDFTRVSYEDYKRLLHSLNEVDIGILINNVGMCFDNPEVLHRVEGGIDTLTN 162
Query: 418 VHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALE 477
V + L+ + P + +KSG I+N S +G Y+A K I F+ L E
Sbjct: 163 VINVNILPLTAGILPQMMARKSGIIVNIGSAAGSIHMAKWSVYSATKKYIEWFTSILQKE 222
Query: 478 GTKRGITVNVIAP-HAETAMTKTIFSS 503
GI I P T M K SS
Sbjct: 223 YENEGIICQTITPLLVSTNMIKNPLSS 249
>Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 52.4 bits (124), Expect = 3e-06
Identities = 50/193 (25%), Positives = 90/193 (45%), Gaps = 11/193 (5%)
Query: 6 KDRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSV-VQEIKKLGGEGDAVANY 64
+D+ V ITG G G + A + RG +V+ L A+ + Q +L V
Sbjct: 28 QDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKM 87
Query: 65 DSVSDNGAAIVETAISNFGRVDI--LINNAGILRDSSFAK-MSEKQFQQVIDVHLNGAFK 121
+S+ AA + + G + L+NNAGIL + + ++ + ++ V+L G +
Sbjct: 88 ESI----AAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQ 143
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINV 181
+T + P +R+ + GRI+N S G F Y +K G+ F + L +E + + +
Sbjct: 144 VTLSMLPLVRRAR-GRIVNVSSILGRVA-FFVGGYCVSKYGVEAFSDILRREIQHFGVKI 201
Query: 182 NSIAP-LARSAMT 193
+ + P R+ MT
Sbjct: 202 SIVEPGYFRTGMT 214
>7302393 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 355
Score = 52.4 bits (124), Expect = 3e-06
Identities = 50/203 (24%), Positives = 93/203 (45%), Gaps = 31/203 (15%)
Query: 314 KVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP----SAVVDEINKKYGSGSAVADTH 369
++ +ITG G+G + VV+ +RDP +AV ++ G + +
Sbjct: 68 RIAVITGGNRGIGLRIVEKLLACDMTVVMG-VRDPKIAETAVASIVDLNATKGKLICEQL 126
Query: 370 DI--VKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFA--KMTEDEWNAVINVHLFSTFA 425
D+ +K + Q +++ +VD+L+NNAGI+ FA K+T D + + ++ F
Sbjct: 127 DVGDLKSVKAFAQLIKERYSKVDLLLNNAGIM----FAPFKLTADGYESHFAINFLGHFL 182
Query: 426 LSKAVWPIF----LKQKSGYIINTTSTSGIYG--NFGQCN----------YAAAKAAILG 469
L+ + P + ++ I+N +S + G N+ N Y+ +K A +
Sbjct: 183 LTHLLLPQLRAAGKEGRNSRIVNVSSCVNLIGRINYKDINGTKHYYPGTAYSQSKLAQIL 242
Query: 470 FSRTL--ALEGTKRGITVNVIAP 490
F+R L L+ K + VNV+ P
Sbjct: 243 FTRHLQTLLDAEKSHVQVNVVHP 265
>7298167 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 256
Score = 52.4 bits (124), Expect = 3e-06
Identities = 45/188 (23%), Positives = 82/188 (42%), Gaps = 15/188 (7%)
Query: 310 SLRGKVVIITGSGSGLGKSHAQWFARYGAK--VVINDIRDPSAVVD--EINKKYGSGSAV 365
+L K VI G+G ++ + K V+++ I +P+A+ + IN K
Sbjct: 4 TLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFYP 63
Query: 366 ADTHDIVKEAQQVVQTAVDKFGRVDILVNNAGILRDRSFAKMTEDEWNAVINVHLFSTFA 425
D + E ++++T + VD+L+N AGIL D + + ++N
Sbjct: 64 YDVTVPIAETTKLLKTIFAQLKTVDVLINGAGILDDHQIERTIAVNYTGLVNT------- 116
Query: 426 LSKAVWPIFLKQK---SGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRG 482
+ A+ + K+K G I N S +G + Y+ KAA++ F+ +LA G
Sbjct: 117 -TTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLAKLAPITG 175
Query: 483 ITVNVIAP 490
+T + P
Sbjct: 176 VTAYTVNP 183
>Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 313
Score = 52.0 bits (123), Expect = 4e-06
Identities = 48/182 (26%), Positives = 83/182 (45%), Gaps = 6/182 (3%)
Query: 7 DRVVIITGAGGGLGRVYALEYAKRGGKVVVNDLGRSAADSVVQEIK-KLGGEGDAVANYD 65
++ V ITG G G + A + RG +V+ + + ++ +L V +
Sbjct: 25 EKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKSE 84
Query: 66 SVSDNGAAIVETAISNFGRVDILINNAGI-LRDSSFAKMSEKQFQQVIDVHLNGAFKLTR 124
S+ A V + G + L+NNAG+ L +++ F +VI+V+L G ++T
Sbjct: 85 SIK-AAAQWVRDKVGEQG-LWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEVTL 142
Query: 125 AAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAKLGLLGFGESLAKEGYKYNINVNSI 184
P M K+ GR++N S G G Y +K G+ F +S+ +E Y + + V I
Sbjct: 143 HMLP-MVKRARGRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDSIRRELYYFGVKVCII 200
Query: 185 AP 186
P
Sbjct: 201 EP 202
Score = 51.6 bits (122), Expect = 5e-06
Identities = 50/186 (26%), Positives = 88/186 (46%), Gaps = 6/186 (3%)
Query: 308 IKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEINKKYGSGSAVAD 367
+ +L K V ITG SG G A+ G +V+ + + + + Y + + D
Sbjct: 20 VGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLD 79
Query: 368 T--HDIVKEAQQVVQTAVDKFGRVDILVNNAGI-LRDRSFAKMTEDEWNAVINVHLFSTF 424
+ +K A Q V+ V + G + LVNNAG+ L +T+D++ VINV+L
Sbjct: 80 VTKSESIKAAAQWVRDKVGEQG-LWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLI 138
Query: 425 ALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCNYAAAKAAILGFSRTLALEGTKRGIT 484
++ + P+ +K+ G ++N +S+ G G Y +K + FS ++ E G+
Sbjct: 139 EVTLHMLPM-VKRARGRVVNMSSSGGRVAVIGG-GYCVSKFGVEAFSDSIRRELYYFGVK 196
Query: 485 VNVIAP 490
V +I P
Sbjct: 197 VCIIEP 202
>7304177 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 300
Score = 52.0 bits (123), Expect = 4e-06
Identities = 51/197 (25%), Positives = 87/197 (43%), Gaps = 24/197 (12%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVV--NDLGR--SAADSVVQEI--KKLGGEGDAV 61
+V I+TGA G+G+ LE AKRGG V + D+ R A +++E + + +
Sbjct: 15 KVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQNIFSRELDL 74
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFK 121
++ +S+ A + ++ +LINNAG++ +++ F+ + V+ G F
Sbjct: 75 SSLESIRKFAAGFKKEQ----DKLHVLINNAGVMHCP--RTLTKDGFEMQLGVNHMGHFL 128
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQAN------------YSAAKLGLLGFGES 169
LT ++K RI+N S G A+ YS +KL + F
Sbjct: 129 LTHLLLDVLKKTAPSRIVNVSSLVHTQGFIKTADLNSEKSYSRIGAYSQSKLANVLFTRE 188
Query: 170 LAKEGYKYNINVNSIAP 186
LAK + NS+ P
Sbjct: 189 LAKRLEGTGVTTNSLHP 205
>7290709 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 406
Score = 52.0 bits (123), Expect = 4e-06
Identities = 46/159 (28%), Positives = 74/159 (45%), Gaps = 12/159 (7%)
Query: 8 RVVIITGAGGGLGRVYALEYAKRGGKVVV--NDLGRSAADSV----VQEIKKLGGEGDAV 61
+VVI+TG G+G+ LE AKRG +V + D GR A + ++L +
Sbjct: 75 KVVIVTGCNTGIGKETVLELAKRGARVYMACRDPGRCEAARLDIMDRSRNQQLFNRTLDL 134
Query: 62 ANYDSVSDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNGAFK 121
+ SV + VE + R+DILINNAG++ + ++ F+Q V+ G F
Sbjct: 135 GSLQSVRN----FVERFKAEESRLDILINNAGVM--ACPRTLTADGFEQQFGVNHLGHFL 188
Query: 122 LTRAAWPHMRKQKFGRIINTCSPAGLYGNFGQANYSAAK 160
LT ++ RI+ S A L+G + + + K
Sbjct: 189 LTNLLLDRLKHSSPSRIVVVSSAAHLFGRINREDLMSEK 227
Score = 50.8 bits (120), Expect = 9e-06
Identities = 62/235 (26%), Positives = 104/235 (43%), Gaps = 37/235 (15%)
Query: 304 GPIPIKSLR--GKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDP---SAVVDEINKK 358
GP K+ R GKVVI+TG +G+GK A+ GA+V + RDP A +I +
Sbjct: 63 GPAYRKANRIDGKVVIVTGCNTGIGKETVLELAKRGARVYM-ACRDPGRCEAARLDIMDR 121
Query: 359 YGSGSAVADTHDIVKEAQQVVQTAVDKF----GRVDILVNNAGILRDRSFAKMTEDEWNA 414
+ T D+ + Q V+ V++F R+DIL+NNAG++ +T D +
Sbjct: 122 SRNQQLFNRTLDL--GSLQSVRNFVERFKAEESRLDILINNAGVM--ACPRTLTADGFEQ 177
Query: 415 VINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYGNFGQCN-------------YA 461
V+ F L+ + I+ +S + ++G + + Y+
Sbjct: 178 QFGVNHLGHFLLTNLLLDRLKHSSPSRIVVVSSAAHLFGRINREDLMSEKNYSKFFGAYS 237
Query: 462 AAKAAILGFSRTLALEGTKRGITVNVIAPHAETAMTKTIFSSKELNNHFD-PGFV 515
+K A + F+ L+ G+TVN P + +T E+N HF PG++
Sbjct: 238 QSKLANILFTLKLSTILKDTGVTVNCCHP----GVVRT-----EINRHFSGPGWM 283
>At5g53090 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 364
Score = 51.2 bits (121), Expect = 7e-06
Identities = 44/171 (25%), Positives = 77/171 (44%), Gaps = 18/171 (10%)
Query: 296 RELPENKNGPIPIKSLRGKVVIITGSGSGLGKSHAQWFARYGAKVVINDIRDPSAVVDEI 355
R + + P+P+ SL I+TGS SG+G+ A+ A GA+VV+ +R+ A + I
Sbjct: 28 RFMASHLQNPLPLPSLNHLTCIVTGSTSGIGRETARQLAEAGARVVM-AVRNTKAAHELI 86
Query: 356 N--KKYGSGSAVADTHDIVKEAQQVVQTAVD-----------KFGRVDILVNNAGILRDR 402
+K SG + + EA ++ ++D + + +L+NNAGI
Sbjct: 87 QQWQKEWSGKGI----PLNLEAMELDLLSLDSVVGFCNLWNARLSPLHVLINNAGIFSMG 142
Query: 403 SFAKMTEDEWNAVINVHLFSTFALSKAVWPIFLKQKSGYIINTTSTSGIYG 453
K ++D + + V+ + LS + P ++ IIN S G
Sbjct: 143 EEQKFSKDGYEQHMQVNHLAPALLSLLLLPSLIRGSPSRIINVNSVMHYVG 193
>7294121 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 482
Score = 51.2 bits (121), Expect = 7e-06
Identities = 49/176 (27%), Positives = 82/176 (45%), Gaps = 18/176 (10%)
Query: 3 LEFKDRVVIITGAGGGLGRVYALEYAKRGGKVV-VNDLGRSAADSVVQEIKKLGGEGDAV 61
++ + V+ G GG+G+ E +R K + + DL +A + ++ + K + D
Sbjct: 1 MDLAGKNVVYLGGFGGIGQKCVQELLQRPIKALAIFDL--NANEQLLAKWKSQHPDTDVF 58
Query: 62 ANYDSV---SDNGAAIVETAISNFGRVDILINNAGILRDSSFAKMSEKQFQQVIDVHLNG 118
+ + SD AA TA FG D+++N +G++ D + + I ++L G
Sbjct: 59 YHKLDITQKSDIDAAYKATA-ERFGHFDVVVNGSGLMND--------RLVELTIQINLLG 109
Query: 119 AFKLTRAAWPHMRKQKFGR---IINTCSPAGLYGNFGQANYSAAKLGLLGFGESLA 171
T A +M K K G+ I+N S AGL A YSAAK G+ F ++A
Sbjct: 110 VINSTLTALEYMDKAKGGKGGLIVNISSVAGLQPTAIMAIYSAAKTGVTTFTRAMA 165
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.135 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,828,968
Number of Sequences: 60738
Number of extensions: 2353424
Number of successful extensions: 6989
Number of sequences better than 1.0e-05: 194
Number of HSP's better than 0.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 150
Number of HSP's that attempted gapping in prelim test: 6192
Number of HSP's gapped (non-prelim): 410
length of query: 889
length of database: 30,389,216
effective HSP length: 115
effective length of query: 774
effective length of database: 23,404,346
effective search space: 18114963804
effective search space used: 18114963804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)