ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV3630 good D KOG2168 Cell cycle control, cell division, chromosome partitioning Cullins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV3630 1256795 1254216 -860
(860 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YFR002w [D] KOG2168 Cullins 878 0.0
SPCC1620.11 [D] KOG2168 Cullins 307 5e-83
SPCC1739.14 [D] KOG2168 Cullins 244 4e-64
Hs7661902 [D] KOG2168 Cullins 214 6e-55
Hs20561607 [D] KOG2168 Cullins 193 8e-49
7292936 [D] KOG2168 Cullins 102 2e-21
CE26832 [D] KOG2168 Cullins 100 1e-20
7299939 [D] KOG2168 Cullins 89 3e-17
>YFR002w [D] KOG2168 Cullins
Length = 839
Score = 878 bits (2268), Expect = 0.0
Identities = 443/827 (53%), Positives = 588/827 (70%), Gaps = 11/827 (1%)
Query: 35 NELLETSKNLPSTSSDLGAILLSVNEMKKRAQEMRKTIPHDSNHTKAHYLLAGSGLEFHX 94
NELLE+S NLPS SS+LG+I +S+NE+++R ++R ++TKAHYLLA SGL F
Sbjct: 23 NELLESSDNLPSASSELGSIQVSINELRRRVFQLRSKNKASKDYTKAHYLLANSGLSFED 82
Query: 95 XXXXXXXXXXXXXXXXQRVAQGYNDGDLDTYLHIKKDENILSSIEQSLSLAAKDFDNFIN 154
+ +L+ Y+ KK+ENIL SIEQ L+ A KDFDNFIN
Sbjct: 83 VDAFIKDLQTNQFLE-PNPPKIIESEELEFYIRTKKEENILMSIEQLLNGATKDFDNFIN 141
Query: 155 QNFNLDWKQRKDEVRESFGILVKKRQDSSNYD-TTNLAPLDPNGPIFWGKPPGSGILDGD 213
N NLDW Q K+EV ++FGIL+ QD D +++ LDP P WG + + +
Sbjct: 142 HNLNLDWAQHKNEVMKNFGILI---QDKKTVDHKKSISSLDPKLPS-WGNKGNNILNSNE 197
Query: 214 LNSNVNGNHILREKFEKYAKIIYRFNNSRQSHNDDFQLTKEFIAIFQNTTDSKYRQLLDG 273
NVN N+ILREKFE YA+I+++FNNSRQ+ N +F + EFI+I + ++ QLL+
Sbjct: 198 SRLNVNENNILREKFENYARIVFQFNNSRQA-NGNFDIANEFISILSSANGTRNAQLLES 256
Query: 274 WEIIDNATNQSPNIVEFSKKYLENQFLSYVDNLYSKNPSEGLPTNVNKIRAFIDLKLKTG 333
W+I+++ ++ NIVE K+YLE QFL Y DNLY KN +EGL TNVNKI++FID KLK
Sbjct: 257 WKILESMKSKDINIVEVGKQYLEQQFLQYTDNLYKKNMNEGLATNVNKIKSFIDTKLKKA 316
Query: 334 ENTWKFNNLTIVNGIPVWALIFYLLRAGLPQDALEVVVNNKLSFKKVEQSFLTYFKAYVT 393
+ +WK +NLT++NG+P+WALIFYLLRAGL ++AL+V+V NK + KKVEQSFLTYFKAY +
Sbjct: 317 DKSWKISNLTVINGVPIWALIFYLLRAGLIKEALQVLVENKANIKKVEQSFLTYFKAYAS 376
Query: 394 SPDHRLPQEFVSRLHTEYNQHIKNTLDSDPFRLAVYKIIGRCDLTRKNISSITLSVEDWL 453
S DH LP E+ ++LHTEYNQHIK++LD DP+RLAVYK+IGRCDL+RKNI ++TLS+EDWL
Sbjct: 377 SKDHGLPVEYSTKLHTEYNQHIKSSLDGDPYRLAVYKLIGRCDLSRKNIPAVTLSIEDWL 436
Query: 454 WIHLMLIKXXXXXXXPVYERYTLSDFQHTVVSYGEYMFKNYYLQALLLSGQYELAVQYSY 513
W+HLMLIK PVYERY+L DFQ+ ++SYG F NYYLQ LLLSG Y LA+ Y+Y
Sbjct: 437 WMHLMLIKEKDAENDPVYERYSLEDFQNIIISYGPSRFSNYYLQTLLLSGLYGLAIDYTY 496
Query: 514 KINEIDAVHLAIGLAANGMLHVSSYKKDELISVNDGQTRINFVKVLGNYTKSFKYSDPRI 573
+E+DAVHLAIGLA+ + + S + + I F +L NYTKSF+YSDPR+
Sbjct: 497 TFSEMDAVHLAIGLASLKLFKIDSSTR----LTKKPKRDIRFANILANYTKSFRYSDPRV 552
Query: 574 AVEYLILIALVNEKEQIEWAYEALRELILETKEFTILLGKINSEGIRIPGVVEERRPLLQ 633
AVEYL+LI L +E +EALREL+LETKEFT+LLGKI +G RIPGV+EER+PLL
Sbjct: 553 AVEYLVLITLNEGPTDVELCHEALRELVLETKEFTVLLGKIGRDGARIPGVIEERQPLLH 612
Query: 634 LEDQKDFLYKITXXXXXXXXXXXXIHDSLLLYQLSEEYDIVMSIINKLLGELLSSTDLNQ 693
+ D+K+FL+ IT I+DS+LLYQL+EEYDIV++++N LL + LS++DL+Q
Sbjct: 613 VRDEKEFLHTITEQAARRADEDGRIYDSILLYQLAEEYDIVITLVNSLLSDTLSASDLDQ 672
Query: 694 SLFRLNDNSETNYVLMAKKLIEVYINNIEISKKVQARNKETCIVLLKLADIRASFLARQW 753
L +DNSETN VL+A+++ +Y +N IS+++ +NKE C++LL ++ IR + +QW
Sbjct: 673 PLVGPDDNSETNPVLLARRMASIYFDNAGISRQIHVKNKEICMLLLNISSIRELYFNKQW 732
Query: 754 QNTLQQIEDLDLIPFTDESSTRKRAQEFTHLDEXXXXXXXXXXXXTMLCISNIIKQLNES 813
Q TL Q+E LDL+PF+DE S RK+AQ+F++LD+ T+ CISN+I LNES
Sbjct: 733 QETLSQMELLDLLPFSDELSARKKAQDFSNLDDNIVKNIPNLLIITLSCISNMIHILNES 792
Query: 814 DYQSLTKKQQIDSLKRVAKNCMIYAGMIQYKMPRETYSILINIEVGL 860
YQS TK QQIDSLK VA+ CMIYAGMIQY+MPRETYS LINI+V L
Sbjct: 793 KYQSSTKGQQIDSLKNVARQCMIYAGMIQYRMPRETYSTLINIDVSL 839
>SPCC1620.11 [D] KOG2168 Cullins
Length = 851
Score = 307 bits (786), Expect = 5e-83
Identities = 244/868 (28%), Positives = 415/868 (47%), Gaps = 86/868 (9%)
Query: 33 LFNELLETSKNLPSTSSDLGAILLSVNEMKKRAQEMRKTIPHDSN-HTKAHYLLAGSGLE 91
L NELLE LP +LG E+++RA+ T+P + +TKAHYLLAGSG+
Sbjct: 25 LANELLEPC--LPFIQFNLG-------EIEQRAKHYLNTVPTSKDGNTKAHYLLAGSGIN 75
Query: 92 FHXXXXXXXXXXXXXXXXXQRVAQGYNDGDLDTYLHIKKDENILSSIEQSLSLAAKDFDN 151
+ D+D +L +++N+L+S+E + FD
Sbjct: 76 ---AEQTWKKIESLSLQVRPPTTLELSFTDVDMFLKYHREKNVLNSLEALVQNTQIAFDQ 132
Query: 152 FINQNFNLDWKQRKDEVRESFGILV---KKR--------QDSSNYDTTNLAPLDPNGPIF 200
++ + +W+ + + R SF ++ KKR Q S + +T L+
Sbjct: 133 YLEE----EWRSKAAKSRPSFDNILLENKKRVSFYPFSVQRSQKFASTLKMCLEEEA--- 185
Query: 201 WGKPPGSGILDGDLNSNVNGNHILREKFEKYAKIIYRFNNSRQSHNDDFQLTKEFIAIFQ 260
L G + V+ + +F K + + + + + L K+ + +F
Sbjct: 186 ---------LHGFQSKLVSSFCEVAREFAHDTKSLLLYESWKLLSS--VILDKDSVTVFG 234
Query: 261 NT-TDSKYRQLLDGWEIIDNATNQS--PNIVEFSKKYLENQFLSYVDNLYSKNPSE---- 313
N SK + E D + N I + S+K+LE QF ++ +K P
Sbjct: 235 NKGIISKAFDI----ETEDGSVNSRFYQRISDCSRKFLEAQFFEVLNKEIAKTPQAALVG 290
Query: 314 GLPTNVNKIRAFIDLKLKTGENTWKFNNLTIVNGIPVWALIFYLLRAGLPQDALEVVVNN 373
G+P+ NKIRA+++++L W +L I+ +P+WA IFYLLR G ++A++ N
Sbjct: 291 GVPSIRNKIRAYLNIRLLRN-GVWINPDLEIIQDVPIWAFIFYLLRCGFLKEAVDFTEEN 349
Query: 374 KLSFKKVEQSFLTYFKAYVTSPDHRLPQEFVSRLHTEYNQHIKNTLDSDPFRLAVYKIIG 433
+ F+KV + F Y AY +P+ LP++ S+L +E+NQ I+ SDP++ AVYKIIG
Sbjct: 350 RDLFEKVAEKFPFYINAYAKAPNGILPRQLRSQLFSEFNQTIRLQESSDPYKYAVYKIIG 409
Query: 434 RCDLTRKNISSITLSVEDWLWIHLMLIKXXXXXXXPVYERYTLSDFQHTVVSYGEYMFKN 493
RCDL++ + SI ED++W L+L + +E ++L D QH ++SYG F N
Sbjct: 410 RCDLSKTSCPSICSVTEDYIWFQLILSREFTEKSVSAHEFFSLEDVQHILLSYGSDYFTN 469
Query: 494 ------YYLQALLLSGQYELAVQYSYKINEIDAVHLAIGLAANGMLHV---SSYKKDE-- 542
Y L+L G YE A+ + Y DAVH AI A G+L SS +E
Sbjct: 470 NGSNPVMYFFLLMLCGLYERAINFLYPYFPTDAVHFAITCAYYGLLRTAPSSSVVSNEPG 529
Query: 543 -----LISVNDGQTRINFVKVLGNYTKSFKYSDPRIAVEYLILIALVNEKEQIEWAYEAL 597
L+ G+ + F ++L +YT++ + P ++ YLI + ++ + I +++L
Sbjct: 530 KIQSMLVETKSGKPSLEFDRLLIDYTQTCQELSPVMSACYLIPMCKID--KYISMCHKSL 587
Query: 598 RELILETKEFTILLGKINSEGIRIPGVVEERRPLLQLEDQKDFLYKITXXXXXXXXXXXX 657
L+L T+++ LLG I +G R P +E R L+ L K++L KIT
Sbjct: 588 CSLVLSTRDYVNLLGDIRGDGERTPSFLENHRSLIGLSSVKEYLSKITLTAAKQADDQGL 647
Query: 658 IHDSLLLYQLSEEYDIVMSIINKLLGELLSSTDLNQSLFRLNDNSETNYVLMAKKLIEVY 717
+ D++LLY L+E+YD +++IN+ LG L L+Q +F + + K +++VY
Sbjct: 648 LSDAILLYHLAEDYDAAVTVINRRLGSALLRF-LDQFVF------PDKLISLTKSMMDVY 700
Query: 718 INNIEISKKVQARNKETCIVLLKLADIRASFLARQWQ---NTLQQIEDLDLIPFTDESST 774
N + KV +N+ET +LL + ++ + ++ ++LQQ+E L L P + T
Sbjct: 701 NRNPSLYAKVDYKNRETTNLLLLTVEAFNAYTNKDYEQALSSLQQLEILPLDPLDSDCET 760
Query: 775 ---RKRAQEFTHLDEXXXXXXXXXXXXTMLCISNI-IKQLNESDYQSLTKKQQIDSLKRV 830
RK A+EF L+E M + + KQ + S ++ ++
Sbjct: 761 FVVRKLAKEFRFLNENLLQNVPGIVLIAMNSLKELYAKQKSSSFGNDAISVDKLRLYRQK 820
Query: 831 AKNCMIYAGMIQYKMPRETYSILINIEV 858
A+ ++Y+ +I+Y+MP + L E+
Sbjct: 821 ARRIVMYSFLIEYRMPSQILEQLNRCEI 848
>SPCC1739.14 [D] KOG2168 Cullins
Length = 933
Score = 244 bits (623), Expect = 4e-64
Identities = 215/892 (24%), Positives = 394/892 (44%), Gaps = 121/892 (13%)
Query: 54 ILLSVNEMKKRAQEMR-KTIPHDSNHTKAHYLLAGSGLEFHXXXXXXXXXXXXXXXXXQR 112
I +N+++++A+ + K + TKAHYLLA SG+
Sbjct: 47 IQYGLNQLEEKARNLESKVLLTRDGDTKAHYLLAESGMNAEQTRQKIYSI---------H 97
Query: 113 VAQGYNDGDLDT-------YLHIKKDENILSSIEQSLSLAAKDFDNFINQNFNLDWKQRK 165
+ ++ +LD + + +N+++SIE +F + +N + W+ K
Sbjct: 98 IHSPWDQLELDKKSLYEQPHTKLYNGQNVVASIENGYQSNVYEFQLRLMKNNGIAWENTK 157
Query: 166 DEVRESFGILVKKRQDSSNYDTTNLAPLDPN--GPIFWGK-------------------P 204
E E G L+ + D+S T+ L PN P+ P
Sbjct: 158 TEFMEDVGKLLHSK-DNSGLGTSISMSLRPNLARPLLTASSVKSQSVRSLREVGSNLPIP 216
Query: 205 PGSGILDGDLNSNVNGNHILR----------EKFEKYAKIIYRFNNSRQSHNDDFQLTKE 254
GS LN+ ++ N + R EK +A +++ N +R N +
Sbjct: 217 TGSLTKIDGLNNQLS-NDLTRSQTTNIFGFAEKASSFAAAVHKLNEAR-IRNQACHVWSL 274
Query: 255 FIAIFQNTTDSKYRQLLDGWEIIDNATNQS------------------------PNIVEF 290
F ++ Q +++ QL D W ++ + +++ N +E
Sbjct: 275 FASVSQ-MVNTEVIQLFDAWSLLAHMIDETRYGMGDFEARHLALDSSSAALAVEKNCIEG 333
Query: 291 SKKYLENQFLSYVDNLYSKNPSEGLPTNVNKIRAFIDLKL-KTGENTWKFNNLTIVNGIP 349
S KYLENQFLS +D S +V K+ A+ L+ K G +W + +++VN +P
Sbjct: 334 SLKYLENQFLSLIDLHLSDAGHITTVNSVEKVIAYSKLRFYKNG--SWIKSTVSVVNDVP 391
Query: 350 VWALIFYLLRAGLPQDALEVVVNNKLSFKKVEQSFLTYFKAYVTSPDHRLPQEFVSRLHT 409
+W ++FYL+R+G AL+ V F+K+ +SF YF +Y +P LP++ RL
Sbjct: 392 LWVVLFYLMRSGQLDAALQFVNTYSDDFEKLGRSFPLYFYSYAKNPSLPLPKQLRDRLQA 451
Query: 410 EYNQHIKNTLDSDPFRLAVYKIIGRCDLTRKNISSITLSVEDWLWIHLMLIK------XX 463
EY Q +K DPF+ A+YK++G C+ R ++ + ++ ED++WI LM +
Sbjct: 452 EYGQLMKYA-PEDPFKHAIYKLLGNCEPHRVSLPEVCVTSEDYMWIQLMFCRVNQNDVID 510
Query: 464 XXXXXPVYERYTLSDFQHTVVSYGEYMFK-------NYYLQALLLSGQYELAVQYSYKIN 516
+ L + +V++G F NY+L ALL+ G++E A+ + +
Sbjct: 511 SNGGQSTNSLFNLYQLEKKIVAFGPRYFNPKNNTPTNYFL-ALLMCGEFERAISFLHTNY 569
Query: 517 EIDAVHLAIGLAANGMLHVSSYKKDELISVNDG-QTRINFVKVLGNYTKSFKYSDPRIAV 575
++A H A+ +A G+L +Y+K+E I + + +INF +++ Y K +Y D + +
Sbjct: 570 PVEATHFAVAMAYYGLLRTKNYEKNENILIYEADDVKINFPQLIIAYLKHLEYVDAAVYL 629
Query: 576 EYLILIALVNEKEQIEWAYEALRELILETKEFTILLGKINSEGIRIPGVVEERRPLLQLE 635
+Y+ I LV + + + L+L++ EF+ LG I + R G+++ L+ +
Sbjct: 630 DYIACIPLVPAYQAC--SINLTKILLLQSHEFSKFLGDIKPDTERTTGLLDLYLRLIPFD 687
Query: 636 DQKDFLYKITXXXXXXXXXXXXIHDSLLLYQLSEEYDIVMSIINKLLGELLSSTDL--NQ 693
D L K+ DS++LY L +YD V+ + K L + + S L
Sbjct: 688 --HDSLQKLYLEGAREADDDGRFGDSIILYHLLGDYDTVIGVAIKNLSQSIVSRGLWSID 745
Query: 694 SLFRLNDNSETNYV------LMAKKLIEVYINNIEISKKVQARNKETCIVLLKLADIRAS 747
S N + +N V +A L+ +Y +N + S KV A NK+ VLLK+ ++
Sbjct: 746 SKESKNMHISSNVVASEAPDALAANLLAMYESNPKKSAKVSATNKKALKVLLKVVKVQKL 805
Query: 748 FLARQWQNTLQQIEDLDLIPFTD--------------ESSTRKRAQEFTHLDEXXXXXXX 793
+ +W LQ IE LDL+P + + R+RA EF+ +
Sbjct: 806 YGQEKWDEVLQLIEHLDLLPINEVQAEFEPNEQIPPISARLRRRAFEFSTFQDEVLSVIP 865
Query: 794 XXXXXTMLCISNIIKQLNESDYQSLTKKQQIDSLKRVAKNCMIYAGMIQYKM 845
+M I + + +++ + K+++ L+ ++++ MI+ ++
Sbjct: 866 SLMYISMSSIKALYRTISKLPVVNEESKKKLQRLQFKGSMLVMFSTMIESRL 917
>Hs7661902 [D] KOG2168 Cullins
Length = 819
Score = 214 bits (544), Expect = 6e-55
Identities = 221/873 (25%), Positives = 389/873 (44%), Gaps = 110/873 (12%)
Query: 34 FNELLETSKNLPSTS---SDLGAILLSVNEMKKRAQEMR-KTIPHDSNHT---KAHYLLA 86
F ELL+ ++ L + + S+L + ++ E+++ + +R +T+ S T KA LL
Sbjct: 6 FGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKASVLLG 65
Query: 87 GSGLEF-HXXXXXXXXXXXXXXXXXQRVAQGYNDGDLDTYLHIKKDENILSSIEQSLSLA 145
GL+ H + V D D+ +L +KD +LS+IE+S
Sbjct: 66 SRGLDISHISQRLESLSAATTFEPLEPV----KDTDIQGFLKNEKDNALLSAIEESRKRT 121
Query: 146 AKDFDNFINQNFNLDWKQRKDEVRESFGILVKKRQDSSNYDTTNLAPLDPNGPIFWGKPP 205
+ + ++ ++W+Q K + + L+ +D+ ++ + +P+ G PP
Sbjct: 122 FGMAEEYHRESMLVEWEQVKQRILHT---LLASGEDALDFTQES----EPSYISDVG-PP 173
Query: 206 GSGILDGDLNSNVNGNHILREKFEKYAKIIYRFNNSRQSHNDDFQLTKEFIAIFQNTTDS 265
G LD N+ YA+ IY +N + + L + + + +
Sbjct: 174 GRSSLD-----NIE---------MAYARQIYIYNEKIVNGH----LQPNLVDLCASVAEL 215
Query: 266 KYRQLLDGWEIIDNAT------------NQSPNIV--EFSKK---YLENQFLSYV----- 303
+ + D W ++ T N+S V EF ++ YLE + +Y
Sbjct: 216 DDKSISDMWTMVKQMTDVLLTPATDALKNRSSVEVRMEFVRQALAYLEQSYKNYTLVTVF 275
Query: 304 DNLYSKNPSEGLPTNVNKIRAFIDLKLKTGENTWKFNNLTIVNGIPVWALIFYLLRAGLP 363
NL+ G+P +R+F+++KL + V G PVWALI+Y +R G
Sbjct: 276 GNLHQAQLG-GVPGTYQLVRSFLNIKLPAPLPGLQDGE---VEGHPVWALIYYCMRCGDL 331
Query: 364 QDALEVVVNNKLSFKKVEQSFLTYFKAYVTSPDHRLPQEFVSRLHTEYNQHIKNTLDSDP 423
A +VV N+ + E F T+F+ Y+ S D RL ++L Y + ++N ++DP
Sbjct: 332 LAASQVV--NRAQHQLGE--FKTWFQEYMNSKDRRLSPATENKLRLHYRRALRN--NTDP 385
Query: 424 FRLAVYKIIGRCDLTRKNISSITLSVEDWLWIHLMLIKXXXXXXXPVYERYTLSDFQHTV 483
++ AVY IIGRCD+T N S + ED+LW+ L + +R TLS FQ +
Sbjct: 386 YKRAVYCIIGRCDVT-DNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQL 444
Query: 484 VS-YGEYMFKN-----YYLQALLLSGQYELAVQYSYKINEI--DAVHLAIGLAANGMLHV 535
+ YGE F Y Q L L+ Q+E AV + +++ + AVH+A+ L +L
Sbjct: 445 LEDYGESHFTVNQQPFLYFQVLFLTAQFEAAVAFLFRMERLRCHAVHVALVLFELKLLLK 504
Query: 536 SSYKKDELISVNDGQT----RINFVKVLGNYTKSFKYSDPRIAVEYLILIALVNEKEQIE 591
SS + +L+S G R+NFV++L YT+ F+ +DPR A++Y + + +
Sbjct: 505 SSGQSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGEN 564
Query: 592 WAYEALRELILETKEFTILLGKINSEGIRIPGVVEERRPLLQLEDQKDFLYKITXXXXXX 651
+ EL++E++EF ++LGK+ ++G R PGV+++ D K + K+
Sbjct: 565 MFLRCVSELVIESREFDMILGKLENDGSRKPGVIDK-----FTSDTKPIINKV----ASV 615
Query: 652 XXXXXXIHDSLLLYQLSEEYDIVMSIINKLLGELLSSTDLNQSLFRLNDNSETNYVLMAK 711
++ LY L++ D V+ ++NKLL ++ QS ++ MA
Sbjct: 616 AENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQS-------NKERLKNMAL 668
Query: 712 KLIEVY-INNIEISKKVQARNKETCIVLLKLADIRASFLARQWQNTLQQIEDLDLIPFTD 770
+ E Y I +K V + T +LL L + + IE L L+P
Sbjct: 669 SIAERYRAQGISANKFVDS----TFYLLLDLITFFDEYHSGHIDRAFDIIERLKLVPLNQ 724
Query: 771 ESSTRKRAQEFTHLDEXXXXXXXXXXXXTMLCISNIIKQLNESDYQSLTKKQQI-----D 825
E S +R F + + TM + K+L + S ++ Q++
Sbjct: 725 E-SVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSSSSRPQRVIEDRDS 783
Query: 826 SLKRVAKNCMIYAGMIQYKMPRETYSILINIEV 858
L+ A+ + +AGMI Y+ +T + L+ +EV
Sbjct: 784 QLRSQARTLITFAGMIPYRTSGDTNARLVQMEV 816
>Hs20561607 [D] KOG2168 Cullins
Length = 696
Score = 193 bits (491), Expect = 8e-49
Identities = 164/588 (27%), Positives = 275/588 (45%), Gaps = 55/588 (9%)
Query: 294 YLENQFLSYV-----DNLYSKNPSEGLPTNVNKIRAFIDLKLKTGENTWKFNNLTIVNGI 348
YLE + +Y NL+ G+P +R+F+++KL + V G
Sbjct: 138 YLEQSYKNYTLVTVFGNLHQAQLG-GVPGTYQLVRSFLNIKLPAPLPGLQDGE---VEGH 193
Query: 349 PVWALIFYLLRAGLPQDALEVVVNNKLSFKKVEQSFLTYFKAYVTSPDHRLPQEFVSRLH 408
PVWALI+Y +R G A +VV N+ + E F T+F+ Y+ S D RL ++L
Sbjct: 194 PVWALIYYCMRCGDLLAASQVV--NRAQHQLGE--FKTWFQEYMNSKDRRLSPATENKLR 249
Query: 409 TEYNQHIKNTLDSDPFRLAVYKIIGRCDLTRKNISSITLSVEDWLWIHLMLIKXXXXXXX 468
Y + ++N ++DP++ AVY IIGRCD+T N S + ED+LW+ L +
Sbjct: 250 LHYRRALRN--NTDPYKRAVYCIIGRCDVT-DNQSEVADKTEDYLWLKLNQVCFDDDGTS 306
Query: 469 PVYERYTLSDFQHTVVS-YGEYMFKN-----YYLQALLLSGQYELAVQYSYKINEI--DA 520
+R TLS FQ ++ YGE F Y Q L L+ Q+E AV + +++ + A
Sbjct: 307 SPQDRLTLSQFQKQLLEDYGESHFTVNQQPFLYFQVLFLTAQFEAAVAFLFRMERLRCHA 366
Query: 521 VHLAIGLAANGMLHVSSYKKDELISVNDGQT----RINFVKVLGNYTKSFKYSDPRIAVE 576
VH+A+ L +L SS + +L+S G R+NFV++L YT+ F+ +DPR A++
Sbjct: 367 VHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFESTDPREALQ 426
Query: 577 YLILIALVNEKEQIEWAYEALRELILETKEFTILLGKINSEGIRIPGVVEERRPLLQLED 636
Y + + + + EL++E++EF ++LGK+ ++G R PGV+++ D
Sbjct: 427 YFYFLRDEKDSQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDK-----FTSD 481
Query: 637 QKDFLYKITXXXXXXXXXXXXIHDSLLLYQLSEEYDIVMSIINKLLGELLSSTDLNQSLF 696
K + K+ ++ LY L++ D V+ ++NKLL ++ QS
Sbjct: 482 TKPIINKV----ASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQS-- 535
Query: 697 RLNDNSETNYVLMAKKLIEVY-INNIEISKKVQARNKETCIVLLKLADIRASFLARQWQN 755
++ MA + E Y I +K V + T +LL L + +
Sbjct: 536 -----NKERLKNMALSIAERYRAQGISANKFVDS----TFYLLLDLITFFDEYHSGHIDR 586
Query: 756 TLQQIEDLDLIPFTDESSTRKRAQEFTHLDEXXXXXXXXXXXXTMLCISNIIKQLNESDY 815
IE L L+P E S +R F + + TM + K+L +
Sbjct: 587 AFDIIERLKLVPLNQE-SVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSP 645
Query: 816 QSLTKKQQI-----DSLKRVAKNCMIYAGMIQYKMPRETYSILINIEV 858
S ++ Q++ L+ A+ + +AGMI Y+ +T + L+ +EV
Sbjct: 646 SSSSRPQRVIEDRDSQLRSQARTLITFAGMIPYRTSGDTNARLVQMEV 693
>7292936 [D] KOG2168 Cullins
Length = 823
Score = 102 bits (255), Expect = 2e-21
Identities = 132/614 (21%), Positives = 254/614 (40%), Gaps = 76/614 (12%)
Query: 284 SPNIVEFSKKYLENQFLSYVDNLYSKNPSE----GLPTNVNKIRAFIDLKLKTGENTWKF 339
SP VE ++ YLE ++ +Y+ N ++ G+P+ + +R+++ + L+ +
Sbjct: 244 SPQFVEQARTYLERRYRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGL 303
Query: 340 NNLTIVNGIPVWALIFYLLRAGLPQDALEVVVNNKLSFKKVEQSFLTYFKAYVTSPDHRL 399
+++ NG P+W ++Y LR+G DA + + + + LT L
Sbjct: 304 HDVN--NGQPLWPHVYYSLRSG-DMDAAALYLKESGTCPDL----LTLLTLRKNGDRDNL 356
Query: 400 PQEFVSRLHTEYNQHIKNTLDSDPFRLAVYKIIGRCDLTRKNISSITLSVEDWLWIHLML 459
+ +L EYN ++ +DP++ AVY ++ CD ++ + S++D+LW+ L +
Sbjct: 357 MVKLEGQLKLEYNSRLRAC--TDPYKKAVYVVLLACDPHFTHVE-LMRSIDDFLWMQLSI 413
Query: 460 IKXXXXXXXPVYERYTLSDFQHTVVS-YGEYMFKN-----YYLQALLLSGQYELAVQYSY 513
++ E+ T S Q ++ YGE F Y Q L L+GQ+E A+++
Sbjct: 414 LRRSDQSDSNT-EQLTFSGLQSLILEKYGENYFNAREKAALYFQVLTLTGQFEAAIEFLA 472
Query: 514 KI--NEIDAVHLAIGLAANGMLHVSSYKKDELISVNDGQT----RINFVKVLGNYTKSFK 567
+ N A+H+AI L ML + L+S + R+N V+++ YTK F+
Sbjct: 473 RTEKNRTHAIHMAIALNEISMLGTPRSVEQSLLSSDPDDPKPMKRLNLVRLIVMYTKCFE 532
Query: 568 YSDPRIAVEYLILIALVNEKE-------------QIEWAYEALRELILETKEFTILLGKI 614
+D A+ Y L+ + +E + + ELI T++
Sbjct: 533 RTDTTQALHYYYLLRNFKSENGRGNVMLTCVCDLLVEKCDDEMLELIFGTED-------- 584
Query: 615 NSEGIRIPGVVEERRPLLQLEDQKDFLYKITXXXXXXXXXXXXIHDSLLLYQLSEEYDIV 674
G+R G+ E Q+ + Y + ++ LY + + D
Sbjct: 585 KKNGLRYGGIYAE----FQIHECDK--YSLAEMVGDELSKRGDYELAIELYFIGGQLDKA 638
Query: 675 MSIINKLLGELLSSTDLNQSL-FRLND-NSETNYVLMAKKLIEVYINNIEISKKVQARNK 732
+ ++N LL +++ N S+ RL D + + L+ +K +++E+ V
Sbjct: 639 LRLVNSLLAQVVHQPTQNGSVRNRLGDIINRLDAALVVRK------SDVEVQVVV----- 687
Query: 733 ETCIVLLKLADIRASFLARQWQNTLQQIEDLDLIPFT----DESST--RKRAQEFTHL-- 784
T VL K+ + ++ L+ + + LIP + DE T ++ E +
Sbjct: 688 -TYTVLTKVMKFFDHYHEGALRSALEILTNNHLIPASSLEVDECVTNIKRMGPEVIKVLP 746
Query: 785 DEXXXXXXXXXXXXTMLCISNIIKQLNESDYQSLTKKQQIDSLKRVAKNCMIYAGMIQYK 844
D L SN + + + K+ + L+ AK A + Y+
Sbjct: 747 DILLASMDIVYQEYVKLMDSNETASGFFDESKCVNKEPAVKHLRDRAKAFTNMAASVPYR 806
Query: 845 MPRETYSILINIEV 858
MP T L+ +E+
Sbjct: 807 MPSTTNQRLVQLEI 820
>CE26832 [D] KOG2168 Cullins
Length = 787
Score = 100 bits (248), Expect = 1e-20
Identities = 145/682 (21%), Positives = 275/682 (40%), Gaps = 93/682 (13%)
Query: 214 LNSNVNGNH--ILREKFEKYAKIIYRFNNSRQSHNDDFQLTKEFIAIFQNTTDSKYRQLL 271
+N N++ I +K K+ K N ++S D L KE AI ++ TD L
Sbjct: 162 VNKNISDRRELIFGDKLHKFLK-----NQGKKSLVD---LMKE--AIDESGTDGA---LG 208
Query: 272 DGWEIIDNATNQ-----------SPNIVEFSKKYLENQFLSYVDNLYSKNPSEGLPTNVN 320
D W + + N+ + N+VE + KYL+ F ++ + +N +
Sbjct: 209 DVWNDVTSVLNRKTSASRDDLTTTANLVEDACKYLQAVFTEHMQTVVERNLEVAERGGIP 268
Query: 321 KIRAFIDLKLKTGENTWKFNNLTIVNGIPVWALIFYLLRAGLPQDALEVVVNNKLSFKKV 380
R ++ LK G ++G+P W + ++ +RAG + A E + N+L K
Sbjct: 269 GTRGLVNAFLKVGTEESFQPEDDSIDGMPTWQVTYHCVRAGDMKSASETL--NRL--KSF 324
Query: 381 EQSFLTYFKAYVTSPDHRLPQEFVSRLHTEYNQHIKNTLDSDPFRLAVYKIIGRCDLTRK 440
Q + +L E +L E+ ++ +T D ++ A+Y + L
Sbjct: 325 PQCATLVAALNHVAKHGKLDSELKKKLKVEWRHNLAHT--KDKYKRALYAAL----LGGL 378
Query: 441 NISSITLSVEDWLWIHLMLIKXXXXXXXPVYERYTLSDFQHTV-VSYGEYMFKN------ 493
+ +++ ++E+W+W L + P + Q V V YGE F +
Sbjct: 379 DSAALADTLENWIWFKLYPL-----HVDPQLTDVLFKEVQKAVSVDYGEQYFMSNGPSEF 433
Query: 494 -YYLQALLLSGQYELAVQYSYKINE-IDAVHLAIGLAANGMLHVSSYKKDELISVNDGQT 551
Y+ AL LSGQ+E A+ ++ + +D+VH+A+ G L +S DE++ V+ +
Sbjct: 434 QYFFTALWLSGQFERAIYLLHECGQRVDSVHVAVLAHKLGYLRMSKKSTDEMLVVDQNDS 493
Query: 552 ---RINFVKVLGNYTKSFKYSDPRIAVEYLILIALVNEKEQIEWAYEALRELILETKEFT 608
+N +++ YTKSF+ D +++Y L+ + + A+ + T +
Sbjct: 494 TKCHLNLARLIVAYTKSFELVDVPRSLDYWFLLKGITTPTGSDVFEMAVSRSVYLTGQTD 553
Query: 609 ILLGKINSEGIRIPGVVEERRPLLQLEDQKDFLYKITXXXXXXXXXXXXIHDSLLLYQLS 668
+LGK+ +G R G+++E L+D + + ++ +++
Sbjct: 554 EILGKLTPDGRREKGLIDE-----YLDDPSEVICRVASDT-----------------EIT 591
Query: 669 EEYDIVMSIINKLLGELLSSTDLNQSLFRLNDNSETNYVLMAKKLIEVYINNIEISKKV- 727
E+D + + LL+S N ++ ++ SET +K+ ++ ++ E KKV
Sbjct: 592 GEWDQAVGLY------LLASKPTNAAILLSSEISETLRTENKEKIADL-VHVAEQFKKVQ 644
Query: 728 ---QARNKETCIVLLKLADIRASFLARQWQNTLQQIEDLDLIPFTDESSTRKRAQEFTHL 784
QA T +L+ LA + + + L LIP T+ EF +
Sbjct: 645 RGCQASEYATLSLLVDLAVLFDHCRNEEAEIAYGISTHLRLIP-TEPDQVTVIVNEFHMV 703
Query: 785 DEXXXXXXXXXXXXTML-----CISNIIKQLNESDYQSLTKK-QQIDSLKRVAKNCMIYA 838
+ M CI Q N + T + + K ++Y+
Sbjct: 704 PQKVREVLPDMCLHLMKCLVDHCIRQSTTQANRGANSATTSMFSSSNRYVKQIKAIVLYS 763
Query: 839 GMIQYKMPRETYSILINIEVGL 860
+ YK P S L+ ++ L
Sbjct: 764 ATVPYKFPTHVTSRLLQLQASL 785
>7299939 [D] KOG2168 Cullins
Length = 796
Score = 89.0 bits (219), Expect = 3e-17
Identities = 136/666 (20%), Positives = 261/666 (38%), Gaps = 84/666 (12%)
Query: 231 YAKIIYRFNNSRQSHNDDFQLTKEFIAIFQNTTDSKYRQLLDGWEIIDNATN-------- 282
YA+ + +N + L ++F + Q+ D + L D W ++ T
Sbjct: 178 YAQELRHYNELLLKSSHRPNLVQKFAHLSQSFGDCR---LTDMWTLLACVTQISEPLRSD 234
Query: 283 ------QSPNIVEFSKKYLENQF----LSYVDNLYSKNPSEGLPTNVN-KIRAFIDLKLK 331
Q P V ++K YLE ++ S V Y+ N + + VN + RA + L
Sbjct: 235 PIKSRQQRPEFVTYAKSYLERRYRVFMCSQVGGSYANNSYQLVVAYVNHRFRAQQTIGL- 293
Query: 332 TGENTWKFNNLTIVNGIPVWALIFYLLRAGLPQDALEVVVNNKLSFKKVEQSFLTYFKAY 391
+ V IP+W L++Y LR G + A+E + ++ S + +
Sbjct: 294 ----------VDTVREIPLWPLVYYGLRCGAVKVAVEFL-------REAGSSHDEFAQLV 336
Query: 392 VTSPDHRLPQEFVSRLHTEYNQHIKNTLDSDPFRLAVYKIIGRCDLTRKNISSITLSVED 451
+ ++L +Y I+N+ +D ++ AVY I+ CD+ + + +++D
Sbjct: 337 ADRNAGETNSKIENQLRLQYANKIRNS--TDAYKKAVYCILLGCDVNEVH-GEVAKTIDD 393
Query: 452 WLWIHLMLIKXXXXXXXPVYERYTLSDFQHTVVSYGEYMFK-----NYYLQALLLSGQYE 506
+LW+ L +I+ + L YGE F Y + L L+GQ+E
Sbjct: 394 FLWMRLAMIQPGDADNYGKLQSMILE-------QYGEKYFNARQQPYLYFETLALTGQFE 446
Query: 507 LAVQYSYK--INEIDAVHLAIGLAANGMLHVSSYKKDELISVN--DGQ--TRINFVKVLG 560
A+++ + N AVH+AI L G+L + L+S++ D Q R+N +++
Sbjct: 447 AAIEFLARQDENRAHAVHMAIALFELGLLGSARSVSQPLLSIDIKDPQPLRRLNLTRLIR 506
Query: 561 NYTKSFKYSDPRIAVEYLILIALVNEKEQIEWAYEALRELIL-----ETKEFTILLGKIN 615
Y + F+ +D A+ Y + + + + + +L++ +T F ++ GK
Sbjct: 507 QYVQRFERTDTSEALHYYYTLRCLKDSKGRNMFMACVCDLVVDSGVFDTTIFDLIFGKRQ 566
Query: 616 SEGIRIPGVVEERRPLLQLEDQKDFLYKITXXXXXXXXXXXXIHDSLLLYQLSEEYDIVM 675
S R Q E + + S LY+++ +Y++ +
Sbjct: 567 SSDQNDVNSGLFR----QFECPEFDTRTMAAQVGDELAALGNFEMSARLYEMAGKYNLAV 622
Query: 676 SIINKLLGELLSSTDLNQSL-FRLNDNSETNYVLMAKKLIEVYINNIEISKKVQARNKET 734
I L+ +++ L SL RL +++ L+A I+ V+ + K +
Sbjct: 623 KHICILMAQVVHLPTLGGSLRERLGQDAQRFNQLLASDSID-----------VEPKMKSS 671
Query: 735 CIVLLKLADIRASFLARQWQNTLQQIEDLDLIPFTDESSTRKRAQEFTHLDEXXXXXXXX 794
++L L + ++ L + L+P T + L
Sbjct: 672 FVLLQDLLIFFNFYHDGKFNAALDLLRQTQLVPNTLD-DVDVVLGNVKQLSGEVIKVLPD 730
Query: 795 XXXXTMLCISNIIKQLNESDYQSLTKKQQIDSLKRVAKNCMIYAGMIQYKMPRETYSILI 854
M KQL SL ++ Q+ L++ AK A + Y++P +T LI
Sbjct: 731 VIVAAMEIAQKQYKQLKAGSGSSL-EQTQMQQLRQRAKALSNMAATMPYRLPNDTNKRLI 789
Query: 855 NIEVGL 860
+E+ +
Sbjct: 790 ELELDM 795
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,029,086
Number of Sequences: 60738
Number of extensions: 1936888
Number of successful extensions: 5467
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 5415
Number of HSP's gapped (non-prelim): 11
length of query: 860
length of database: 30,389,216
effective HSP length: 115
effective length of query: 745
effective length of database: 23,404,346
effective search space: 17436237770
effective search space used: 17436237770
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)