ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV3906 check: MH R KOG1469 General function prediction only Predicted acyl-CoA dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV3906 1351633 1350239 -465
(465 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
Hs21314747 [R] KOG1469 Predicted acyl-CoA dehydrogenase 153 6e-37
HsM14149851 [R] KOG1469 Predicted acyl-CoA dehydrogenase 152 8e-37
At3g06810 [R] KOG1469 Predicted acyl-CoA dehydrogenase 152 1e-36
CE21068_3 [R] KOG1469 Predicted acyl-CoA dehydrogenase 125 1e-28
Hs13376864 [R] KOG1469 Predicted acyl-CoA dehydrogenase 114 2e-25
Hs7656849 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase 83 8e-16
CE18284 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase 77 4e-14
CE19411 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase 64 6e-10
Hs4504799 [EI] KOG0141 Isovaleryl-CoA dehydrogenase 62 2e-09
CE08612 [I] KOG0139 Short-chain acyl-CoA dehydrogenase 62 2e-09
CE02807 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase 62 2e-09
CE11776 [I] KOG0139 Short-chain acyl-CoA dehydrogenase 60 9e-09
Hs21361497 [I] KOG0137 Very-long-chain acyl-CoA dehydrogenase 59 2e-08
CE07473 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase 58 3e-08
Hs4557231 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase 55 2e-07
7300557 [I] KOG0139 Short-chain acyl-CoA dehydrogenase 55 3e-07
CE09015 [I] KOG0139 Short-chain acyl-CoA dehydrogenase 54 4e-07
7299576 [I] KOG0139 Short-chain acyl-CoA dehydrogenase 54 5e-07
Hs4501859 [I] KOG0139 Short-chain acyl-CoA dehydrogenase 52 2e-06
7293851 [I] KOG0139 Short-chain acyl-CoA dehydrogenase 52 2e-06
7295201 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase 51 4e-06
>Hs21314747 [R] KOG1469 Predicted acyl-CoA dehydrogenase
Length = 391
Score = 153 bits (386), Expect = 6e-37
Identities = 107/344 (31%), Positives = 180/344 (52%), Gaps = 20/344 (5%)
Query: 114 VSMVEFAMIAFLAGRSVIASYLFHLDDLIDLGTIQVLLRNGCSNHDLWVQVIDELVSNNM 173
+S V++A+IA G+ A +F+ D G ++VL G Q ++ L+ N+
Sbjct: 55 LSHVDYALIAEETGKCFFAPDVFNCQ-APDTGNMEVLHLYGSEEQKK--QWLEPLLQGNI 111
Query: 174 KSCLMVSERDVSGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSD--IWLVL 231
SC ++E DV+ SDA N++ C I+ D E + +NG KW+ AG+ I +VL
Sbjct: 112 TSCFCMTEPDVASSDATNIE--CSIQRD-----EDSYVINGKKWWSSGAGNPKCKIAIVL 164
Query: 232 CVTEFDEGNIYRKHTLCLVNRNDLPPNSTRIEPIE----TNEAIGKFYEVQFKDCKVPL- 286
T+ + +++H++ LV N P I P+ T+ G +E+ F +VP
Sbjct: 165 GRTQNTSLSRHKQHSMILVPMNT--PGVKIIRPLSVFGYTDNFHGGHFEIHFNQVRVPAT 222
Query: 287 NIIGERGEGYQILQMKSSVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFK 346
N+I G G++I Q + ++ C++ G+ + +L++ +RA +R F KL E
Sbjct: 223 NLILGEGRGFEISQGRLGPGRIHHCMRTVGLAERALQIMCERATQRIAFKKKLYAHEVVA 282
Query: 347 FDLAHWRIKIETCKLLCFNAAIKCDYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGC 406
+A RI IE +LL AA D G A++EI M+K P+ +S +VDW+IQ+ G
Sbjct: 283 HWIAESRIAIEKIRLLTLKAAHSMDTLGSAGAKKEIAMIKVAAPRAVSKIVDWAIQVCGG 342
Query: 407 YGLCSTQTPLSHMWQVSRSLRINDTPDESLISQLGRLEISNYNK 450
G+ S PL++M+ ++R LR+ D PDE +S + +E+ + K
Sbjct: 343 AGV-SQDYPLANMYAITRVLRLADGPDEVHLSAIATMELRDQAK 385
>HsM14149851 [R] KOG1469 Predicted acyl-CoA dehydrogenase
Length = 391
Score = 152 bits (385), Expect = 8e-37
Identities = 106/344 (30%), Positives = 180/344 (51%), Gaps = 20/344 (5%)
Query: 114 VSMVEFAMIAFLAGRSVIASYLFHLDDLIDLGTIQVLLRNGCSNHDLWVQVIDELVSNNM 173
+S V++A+IA G+ A +F+ D G ++VL G Q ++ L+ N+
Sbjct: 55 LSHVDYALIAEETGKCFFAPDVFNCQ-APDTGNMEVLHLYGSEEQKK--QWLEPLLQGNI 111
Query: 174 KSCLMVSERDVSGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSD--IWLVL 231
SC ++E DV+ SDA N++ C I+ D E + +NG KW+ AG+ + +VL
Sbjct: 112 TSCFCMTEPDVASSDATNIE--CSIQRD-----EDSYVINGKKWWSSGAGNPKCKVAIVL 164
Query: 232 CVTEFDEGNIYRKHTLCLVNRNDLPPNSTRIEPIE----TNEAIGKFYEVQFKDCKVPL- 286
T+ + +++H++ LV N P I P+ T+ G +E+ F +VP
Sbjct: 165 GRTQNTSLSRHKQHSMILVPMNT--PGVKIIRPLSVFGYTDNFHGGHFEIHFNQVRVPAT 222
Query: 287 NIIGERGEGYQILQMKSSVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFK 346
N+I G G++I Q + ++ C++ G+ + +L++ +RA +R F KL E
Sbjct: 223 NLILGEGRGFEISQGRLGPGRIHHCMRTVGLAERALQIMCERATQRIAFKKKLYAHEVVA 282
Query: 347 FDLAHWRIKIETCKLLCFNAAIKCDYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGC 406
+A RI IE +LL AA D G A++EI M+K P+ +S +VDW+IQ+ G
Sbjct: 283 HWIAESRIAIEKIRLLTLKAAHSMDTLGSAGAKKEIAMIKVAAPRAVSKIVDWAIQVCGG 342
Query: 407 YGLCSTQTPLSHMWQVSRSLRINDTPDESLISQLGRLEISNYNK 450
G+ S PL++M+ ++R LR+ D PDE +S + +E+ + K
Sbjct: 343 AGV-SQDYPLANMYAITRVLRLADGPDEVHLSAIATMELRDQAK 385
>At3g06810 [R] KOG1469 Predicted acyl-CoA dehydrogenase
Length = 423
Score = 152 bits (384), Expect = 1e-36
Identities = 121/440 (27%), Positives = 219/440 (49%), Gaps = 31/440 (7%)
Query: 18 DVDP-ITNYIPASVRDKFDERQMDRFKKLRKFVEFECLPLDTVYLQESTLFEHESDLETC 76
DV P + + S R + + ++ +KL KF+E P++ + S L + +
Sbjct: 7 DVSPSYESLVDGSGRFIPNRKVLELRQKLIKFMETHIYPMENEF---SKLAQSDMRWTVH 63
Query: 77 PVIINLRKKLEAYQLHKMFVPMDQRGYDHSFNDNWEVVSMVEFAMIAFLAGRSVIASYLF 136
P L++ + L +FVP +D F + ++ +E+ + + GRSV A +F
Sbjct: 64 PQEEKLKEMAKREGLWNLFVP----SFDQLFGEG---LTNLEYGYLCEIMGRSVWAPQVF 116
Query: 137 HLDDLIDLGTIQVLLRNGCSNHDLWVQVIDELVSNNMKSCLMVSERDVSGSDALNVQTTC 196
+ D G ++V+LR G N + + + L+ ++S ++E V+ SDA N++ +
Sbjct: 117 NCG-APDTGNMEVILRYG--NKEQISEWLIPLLEGRIRSGFAMTEPQVASSDATNIECSI 173
Query: 197 KIEGDDLNEEEATMTLNGTKWFIKDAGDSD--IWLVLCVTEFDEGNIYRKHTLCLVNRND 254
+ +GD + +NGTKW+ A D + +++ T+F+ +++ ++ LV+
Sbjct: 174 RRQGD-------SYVINGTKWWTSGAMDPRCRVLILMGKTDFNAPK-HKQQSMILVDMRT 225
Query: 255 LPPNSTRIEPIET---NEAIGKFYEVQFKDCKVPL-NIIGERGEGYQILQMKSSVTKLFQ 310
P + P+ ++A E+ F++ VP NI+ G G++I Q + +L
Sbjct: 226 --PGISVKRPLTVFGFDDAPHGHAEISFENVVVPAKNILLGEGRGFEIAQGRLGPGRLHH 283
Query: 311 CLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLCFNAAIKC 370
C++L G + + L +RA RK FG + + F DLA R+++E +LL AA
Sbjct: 284 CMRLIGAAERGMELMAQRALSRKTFGKFIAQHGSFVSDLAKLRVELEGTRLLVLEAADHL 343
Query: 371 DYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGCYGLCSTQTPLSHMWQVSRSLRIND 430
D G K AR + M K P ++D +IQ+HG G+ S+ T L+H+W +R+LRI D
Sbjct: 344 DKFGNKKARGILAMAKVAAPNMALKVLDTAIQVHGAAGV-SSDTVLAHLWATARTLRIAD 402
Query: 431 TPDESLISQLGRLEISNYNK 450
PDE + +G+LE+ +K
Sbjct: 403 GPDEVHLGTIGKLELQRASK 422
>CE21068_3 [R] KOG1469 Predicted acyl-CoA dehydrogenase
Length = 417
Score = 125 bits (315), Expect = 1e-28
Identities = 106/415 (25%), Positives = 197/415 (46%), Gaps = 30/415 (7%)
Query: 42 FKKLRKFVEFECLPLDTVYLQESTLFEHESDLETCPVIINLRKKLEAYQLHKMFVPMDQR 101
++ +R+ ++ + +PL+ L+ H + P I L++K ++ +F+ +
Sbjct: 22 YEIVREIIQNDVIPLEQELLEYYEEGPHRWTIPH-PKIEKLKEKSKSLGAWNLFIS-EHI 79
Query: 102 GYDHSFNDNWEVVSMVEFAMIAFLAGRSVIASYLFHLDDLIDLGTIQVLLRNGCSNH-DL 160
+ + ++ VE+A I L GRS+ A +F+ D G ++VL++ G
Sbjct: 80 DPEQKYGKG---LTNVEYAHICELMGRSIFAPEVFNCQ-APDTGNMEVLIKYGSEEQKSK 135
Query: 161 WVQVIDELVSNNMKSCLMVSERDVSGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIK 220
W + L++ +KSC ++E DV+ SDA N+Q + G++ +N KWFI
Sbjct: 136 W---LTPLLNGEIKSCFAMTEPDVASSDATNIQGSIVRVGNEY-------IINARKWFIS 185
Query: 221 DAGDSDIWLVLCVTEFDEGNIYRKHTLCLVNRNDLPPNSTRIEPIETN-------EAIGK 273
+A + + + + R ++ L P T I N +A G
Sbjct: 186 NASHPKCRIAIFMGQVSGAKRSRNLQQSMI----LVPMQTEGVKIIRNTHVFGSQDAPGG 241
Query: 274 FYEVQFKDCKVPL-NIIGERGEGYQILQMKSSVTKLFQCLKLCGMGQESLRLSNKRAAER 332
E+ F + +VP+ N++ G+G++I Q + ++ ++L G + ++ + R R
Sbjct: 242 HPEITFTNVRVPVGNMLLGEGKGFEIAQGRLGPGRIHHAMRLIGHAERAIDVIKDRLLTR 301
Query: 333 KVFGSKLQKSEYFKFDLAHWRIKIETCKLLCFNAAIKCDYEGVKAAREEIGMVKAVTPKE 392
FG KL + + + +LA R ++E +LL AA D G K A+ EI M+K V P
Sbjct: 302 IAFGRKLVQFDSLRKELALSRCEVEQARLLVLKAAHMIDTVGPKEAKSEIAMIKVVAPNM 361
Query: 393 ISSLVDWSIQLHGCYGLCSTQTPLSHMWQVSRSLRINDTPDESLISQLGRLEISN 447
S++D ++Q G GL + TPL+ + +RSLRI D PD + + ++E+ +
Sbjct: 362 AISILDRAMQQQGARGL-TPFTPLASFYVWARSLRIADGPDAVHLETIAKIEMKS 415
>Hs13376864 [R] KOG1469 Predicted acyl-CoA dehydrogenase
Length = 455
Score = 114 bits (286), Expect = 2e-25
Identities = 100/380 (26%), Positives = 176/380 (46%), Gaps = 40/380 (10%)
Query: 59 VYLQESTLFEHESDL---ETCPVIINLRKKLEAYQLHKMFVPMD---QRGYDHSFNDNWE 112
VY E L H++ P+I +L++K +A L +F+P++ ++ Y +
Sbjct: 5 VYPAEPELQSHQASAARWSPSPLIEDLKEKAKAEGLWNLFLPLEADPEKKYGAGLTN--- 61
Query: 113 VVSMVEFAMIAFLAGRSVIASYLFHLDDLIDLGTIQVLLRNGCSNHDLWVQVIDELVSNN 172
VE+A + L G S+ A + + D G +++L+R G + + L+
Sbjct: 62 ----VEYAHLCELMGTSLYAPEVCNCS-APDTGNMELLVRYGTEAQK--ARWLIPLLEGK 114
Query: 173 MKSCLMVSERDVSGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLC 232
+SC ++E V+ SDA N++ + + EE++ +NG KW+I D L +
Sbjct: 115 ARSCFAMTEPQVASSDATNIEAS-------IREEDSFYVINGHKWWITGILDPRCQLCVF 167
Query: 233 VTEFD-EGNIYRKHTLCLVNRNDLPPNSTRIEPIET---NEAIGKFYEVQFKDCKVPL-N 287
+ + D +R+ ++ LV + P I P+ +A G EV+F+ +VP N
Sbjct: 168 MGKTDPHAPRHRQQSVLLVPMDT--PGIKIIRPLTVYGLEDAPGGHGEVRFEHVRVPKEN 225
Query: 288 IIGERGEGYQILQMKSSVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKF 347
++ G G++I Q + ++ C++L G + +L L R R FG L +
Sbjct: 226 MVLGPGRGFEIAQGRLGPGRIHHCMRLIGFSERALALMKARVKSRLAFGKPLVEQGTVLA 285
Query: 348 DLAHWRIKIETCKLLCFNAAIKCDYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGCY 407
D+A R++IE +LL AA D G KAA +I M+K V P S ++D +IQ
Sbjct: 286 DIAQSRVEIEQARLLVLRAAHLMDLAGNKAAALDIAMIKMVAPSMASRVIDRAIQ----- 340
Query: 408 GLCSTQTPLSHMWQVSRSLR 427
+T L W + ++ R
Sbjct: 341 -----KTSLQEAWSLFQARR 355
>Hs7656849 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase
Length = 415
Score = 83.2 bits (204), Expect = 8e-16
Identities = 68/225 (30%), Positives = 103/225 (45%), Gaps = 13/225 (5%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
SGSDA ++ T+ K +GD LNG+K FI AG+SDI++V+C T G K
Sbjct: 165 SGSDAASLLTSAKKQGDHY-------ILNGSKAFISGAGESDIYVVMCRT----GGPGPK 213
Query: 245 HTLCLVNRNDLPPNSTRIEPIETNEAIGKFYEVQFKDCKVPL-NIIGERGEGYQILQMKS 303
C+V P S + + V F+DC VP+ N IG G+G+ I
Sbjct: 214 GISCIVVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGL 273
Query: 304 SVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLC 363
+ ++ G S+ L+ RK FG L ++Y +F LA ++ +L+
Sbjct: 274 NGGRINIASCSLGAAHASVILTRDHLNVRKQFGEPLASNQYLQFTLADMATRLVAARLMV 333
Query: 364 FNAAIKCDYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGCYG 408
NAA+ E K A M K E ++ + ++Q+HG YG
Sbjct: 334 RNAAVALQEER-KDAVALCSMAKLFATDECFAICNQALQMHGGYG 377
>CE18284 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase
Length = 412
Score = 77.4 bits (189), Expect = 4e-14
Identities = 53/218 (24%), Positives = 100/218 (45%), Gaps = 9/218 (4%)
Query: 155 CSNHDLWVQVIDELVSNNMKSCLMVSERDVSGSDALNVQTTCKIEGDDLNEEEATMTLNG 214
C+N D+ + + ++ N + V+E +GSD V+T C+ +GD+ LNG
Sbjct: 123 CANDDIKKRFLGRMIDNPFVASYAVTEPG-AGSDVAGVKTKCEKKGDEY-------ILNG 174
Query: 215 TKWFIKDAGDSDIWLVLCVTEFDEGNIYRKHTLCLVNRNDLPPNSTRIEPIETNEAIGKF 274
+K +I +AG ++ + VL ++ D K V D P + + I +
Sbjct: 175 SKMWITNAGHANWFFVLARSDPDPKTAAGKAFTAFVVEGDTPGLTRGRKEINMGQRCSDT 234
Query: 275 YEVQFKDCKVPL-NIIGERGEGYQILQMKSSVTKLFQCLKLCGMGQESLRLSNKRAAERK 333
+ F+D +VP N++G GEG+++ T+ G+ L ++ + + ERK
Sbjct: 235 RGITFEDVRVPAANVVGAPGEGFKVAMKTFDKTRPTVAALATGVAYRCLDVATQYSLERK 294
Query: 334 VFGSKLQKSEYFKFDLAHWRIKIETCKLLCFNAAIKCD 371
FG+++ + F LA I E +L+ + + + D
Sbjct: 295 AFGTQIANHQGVSFLLAEMAINCELARLMTYKSGAEVD 332
>CE19411 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase
Length = 409
Score = 63.5 bits (153), Expect = 6e-10
Identities = 61/225 (27%), Positives = 99/225 (43%), Gaps = 11/225 (4%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
+GSDA +++TT +GD +NG+K FI AG S+ + V+ D K
Sbjct: 151 AGSDAASIRTTATKKGD-------YYVVNGSKAFISGAGTSNNYFVMM--RQDGAAPGAK 201
Query: 245 HTLCLVNRNDLPPNSTRIEPIETNEAIGKFYEVQFKDCKVPL-NIIGERGEGYQILQMKS 303
CL+ + S + + + F+DCKVP+ N IG+ G G+ I
Sbjct: 202 GIFCLMIEDGTEGFSYGKKEDKLGWNSQPTRILTFEDCKVPITNQIGKDGFGFNIAMAGL 261
Query: 304 SVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLC 363
+ ++ G Q S+ L+ + RK FG L +Y +F LA K+ T +L+
Sbjct: 262 NGGRINIASCSLGAAQRSMDLAIEHLKYRKQFGKSLADFQYNQFKLAELATKLYTSRLIV 321
Query: 364 FNAAIKCDYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGCYG 408
NAA + D + + M K +V+ ++Q+ G YG
Sbjct: 322 RNAAEQLDNDDPEKV-ALCAMAKLHATDNCFDVVNGALQMFGGYG 365
>Hs4504799 [EI] KOG0141 Isovaleryl-CoA dehydrogenase
Length = 423
Score = 62.0 bits (149), Expect = 2e-09
Identities = 59/240 (24%), Positives = 109/240 (44%), Gaps = 13/240 (5%)
Query: 147 IQVLLRNGCSNHDLWVQVIDELVSNNMKSCLMVSERDVSGSDALNVQTTCKIEGDDLNEE 206
I L+RNG N + + +L+S L +SE + +GSD ++++ + +G+
Sbjct: 134 INQLVRNG--NEAQKEKYLPKLISGEYIGALAMSEPN-AGSDVVSMKLKAEKKGNHY--- 187
Query: 207 EATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRKHTLCLVNRNDLPPNSTRIEPIE 266
LNG K++I + D+D+ +V T+ R T +V + +P ST + +
Sbjct: 188 ----ILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKG-MPGFSTSKKLDK 242
Query: 267 TNEAIGKFYEVQFKDCKVPL-NIIGERGEGYQILQMKSSVTKLFQCLKLCGMGQESLRLS 325
E+ F+DCK+P NI+G +G +L + +L G+ Q L +
Sbjct: 243 LGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHT 302
Query: 326 NKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLCFNAAIKCDYEGVKAAREEIGMV 385
R+ FG K+ + + +A ++ C+ +N A CD EG A++ G++
Sbjct: 303 IPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACD-EGHCTAKDCAGVI 361
>CE08612 [I] KOG0139 Short-chain acyl-CoA dehydrogenase
Length = 442
Score = 61.6 bits (148), Expect = 2e-09
Identities = 64/252 (25%), Positives = 121/252 (47%), Gaps = 35/252 (13%)
Query: 169 VSNNMKSCLMVSERDVSGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIW 228
++ ++ S L VSE +GSD V T + +G DL +NG+K +I + G +D W
Sbjct: 171 ITGDLVSSLAVSEPH-AGSDVSAVHTHARRQGSDL-------IINGSKMWITNGGQAD-W 221
Query: 229 LVLCVTEFDEGNIYRKHTLCLVNRNDLPPN-STRIEPI--ETNEAIGKFYEVQFKDCKVP 285
+ V + N+++ +L V + + + ST ++ + +++ + F+E D +VP
Sbjct: 222 ACVLVNTSNTSNVHKNKSLVCVPLDAVGVHRSTPLDKLGMRSSDTVQLFFE----DVRVP 277
Query: 286 LN-IIGE--RGEGYQILQMKSS--VTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQ 340
+ IIGE RG GYQ+ Q VT L L Q+ + + + A +R +FG L
Sbjct: 278 SSYIIGEEGRGFGYQMKQFNDERLVTVAVGLLPL----QKCIDETIEYARDRLLFGKTLL 333
Query: 341 KSEYFKFDLAHWRIKIETCKLLCFNAAIKCDYEGVKAAREEIGMVKAVTPKEIS----SL 396
+Y +F LA ++E + L + + ++ +++ M+ A+ +I ++
Sbjct: 334 DQQYIQFQLAELEAELEATRALLYRTVL------ARSRGDDVSMLTAMAKLKIGRLARAI 387
Query: 397 VDWSIQLHGCYG 408
D +Q+ G G
Sbjct: 388 TDQCLQVWGGAG 399
>CE02807 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase
Length = 412
Score = 61.6 bits (148), Expect = 2e-09
Identities = 58/267 (21%), Positives = 110/267 (40%), Gaps = 11/267 (4%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
+GSD V+T +GD+ +NG+K +I G + + VL T+ + K
Sbjct: 149 AGSDVNGVKTKAVKQGDEY-------IINGSKAWITGGGHAKWFFVLARTDDNPKTPAGK 201
Query: 245 HTLCLVNRNDLPPNSTRIEPIETNEAIGKFYEVQFKDCKVPL-NIIGERGEGYQILQMKS 303
+ D P + + + + F+D +VP NI+G G G+++
Sbjct: 202 AFTAFIVDGDTPGITRGKKENNMGQRCSDTRSITFEDVRVPKENILGAPGAGFKVAMGAF 261
Query: 304 SVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLC 363
+T+ G+ L S K A ER FG+ + + +F +A I +E +L
Sbjct: 262 DLTRPQVAASAVGLAWRCLDESTKYAMERHAFGTPIANHQGVQFMIADMAINLELSRLFT 321
Query: 364 FNAAIKCDYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGCYGLCSTQTPLSHMWQVS 423
+ AA + D GV + I A +++ + Q+ G G + + P+ + + +
Sbjct: 322 YRAAAEVDSYGVSSYNASIAKCFAADTANVAATN--ACQIFGGAGF-NCEYPVEKLMRDA 378
Query: 424 RSLRINDTPDESLISQLGRLEISNYNK 450
+ +I + + +GR N+ K
Sbjct: 379 KIYQIYEGTSQIQRMVIGRTLFQNFAK 405
>CE11776 [I] KOG0139 Short-chain acyl-CoA dehydrogenase
Length = 419
Score = 59.7 bits (143), Expect = 9e-09
Identities = 58/220 (26%), Positives = 101/220 (45%), Gaps = 17/220 (7%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
SGSDA ++TT K +GDD ++G+K +I +AG + +LV + +G Y+
Sbjct: 164 SGSDAFALKTTAKKDGDDF-------VISGSKMWITNAGHAQFFLVFANADSAKG--YKG 214
Query: 245 HTLCLVNRNDLPPNSTRIEPIETNEAIGKFYEVQFKDCKV-PLNIIGERGEGYQILQMKS 303
T LV+RN + + E + V F + +V +I+GE G+GY+
Sbjct: 215 ITCFLVDRNQEGVSVGKKED-KLGIRASSTCSVHFDNVRVHKSSILGEYGKGYKYAIECL 273
Query: 304 SVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLC 363
+ ++ ++ G+ Q + +R+ FG +L + + + R++IE +LL
Sbjct: 274 NAGRIGIGAQMLGLAQGCFDQTIPYLQQREQFGQRLIDFQGMQHQIGQTRMEIEAARLLV 333
Query: 364 FNAAIKCDYEGVKAAREEIGMVK----AVTPKEISSLVDW 399
+NAA + G+ R E M K V S V+W
Sbjct: 334 YNAA-RMKQNGLPFVR-EAAMAKLFASQVATTATSKCVEW 371
>Hs21361497 [I] KOG0137 Very-long-chain acyl-CoA dehydrogenase
Length = 621
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/284 (22%), Positives = 122/284 (42%), Gaps = 22/284 (7%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEF--DEGNIY 242
SGSDA ++++ L+E++ LNG+K +I + G ++I+ V TE +G++
Sbjct: 185 SGSDAASIRSRAT-----LSEDKKHYILNGSKVWITNGGLANIFTVFAKTEVVDSDGSVK 239
Query: 243 RKHTLCLVNR------NDLPPNSTRIEPIETNEAIGKFYEVQFKDCKVPL-NIIGERGEG 295
K T +V R N P + I T EV F++ K+P+ NI+GE G+G
Sbjct: 240 DKITAFIVERDFGGVTNGKPEDKLGIRGSNT-------CEVHFENTKIPVENILGEVGDG 292
Query: 296 YQILQMKSSVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIK 355
+++ + + + G+ + + ++ + A RK F +L + + A K
Sbjct: 293 FKVAMNILNSGRFSMGSVVAGLLKRLIEMTAEYACTRKQFNKRLSEFGLIQEKFALMAQK 352
Query: 356 IETCKLLCFNAAIKCDYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGCYGLCSTQTP 415
+ + + A D G E MVK + + V ++Q+ G G + P
Sbjct: 353 AYVMESMTYLTAGMLDQPGFPDCSIEAAMVKVFSSEAAWQCVSEALQILGGLGY-TRDYP 411
Query: 416 LSHMWQVSRSLRINDTPDESLISQLGRLEISNYNKFQKTYDQEL 459
+ + +R L I + +E L + + + + T EL
Sbjct: 412 YERILRDTRILLIFEGTNEILRMYIALTGLQHAGRILTTRIHEL 455
>CE07473 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase
Length = 417
Score = 57.8 bits (138), Expect = 3e-08
Identities = 44/188 (23%), Positives = 82/188 (43%), Gaps = 8/188 (4%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
+GSD V+T C+ +GD+ +NG+K +I G + + VL ++ + K
Sbjct: 155 AGSDVNGVKTKCEKKGDEY-------IINGSKAWITGGGHAKWFFVLARSDPNPKTPAGK 207
Query: 245 HTLCLVNRNDLPPNSTRIEPIETNEAIGKFYEVQFKDCKVPL-NIIGERGEGYQILQMKS 303
+ D P + + + + F+D +VP N++G G G+++
Sbjct: 208 AFTAFIVDGDTPGITRGKKEKNMGQRCSDTRVITFEDVRVPAENVLGAPGAGFKVAMEAF 267
Query: 304 SVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLC 363
+T+ G+ L S K A ERK FG+ + + +F LA + +E +L+
Sbjct: 268 DMTRPGVAAGALGLSWRCLDESAKYALERKAFGTVIANHQAVQFMLADMAVNLELARLIT 327
Query: 364 FNAAIKCD 371
+ +A D
Sbjct: 328 YKSANDVD 335
>Hs4557231 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase
Length = 421
Score = 55.5 bits (132), Expect = 2e-07
Identities = 44/188 (23%), Positives = 81/188 (42%), Gaps = 8/188 (4%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
+GSD ++T + +GD+ +NG K +I + G ++ + +L ++ D K
Sbjct: 165 AGSDVAGIKTKAEKKGDEY-------IINGQKMWITNGGKANWYFLLARSDPDPKAPANK 217
Query: 245 HTLCLVNRNDLPPNSTRIEPIETNEAIGKFYEVQFKDCKVPL-NIIGERGEGYQILQMKS 303
+ D P + + + + F+D KVP N++ G G+++
Sbjct: 218 AFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAF 277
Query: 304 SVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLC 363
T+ G+ Q +L + K A ERK FG L + + F LA +K+E ++
Sbjct: 278 DKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY 337
Query: 364 FNAAIKCD 371
AA + D
Sbjct: 338 QRAAWEVD 345
>7300557 [I] KOG0139 Short-chain acyl-CoA dehydrogenase
Length = 405
Score = 54.7 bits (130), Expect = 3e-07
Identities = 67/276 (24%), Positives = 120/276 (43%), Gaps = 28/276 (10%)
Query: 176 CLMVSERDVSGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTE 235
C +SE +GSDA T +GD LNGTK +I +A +++ +V T
Sbjct: 144 CFALSEPG-NGSDAGAASTIATDKGDHF-------VLNGTKAWITNAFEAEAAIVFATT- 194
Query: 236 FDEGNIYRKHTLCLVNRNDLPPNSTRIEPIETNEAIG----KFYEVQFKDCKVPL-NIIG 290
N KH ++ +P + + + +G ++ F+DC VP N++G
Sbjct: 195 ----NKQLKHKG--ISAFIVPKATKGFSLGKKEDKLGIRGSSTCQLIFEDCVVPKENMLG 248
Query: 291 ERGEGYQILQMKSSVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLA 350
E G G++I ++ + G+GQ +L L+ A +R+ FG + K + + +A
Sbjct: 249 EPGFGFKIAMQTLDAGRIGIAGQALGIGQAALELAVDYAQKRQAFGKPIAKLQSIQQKIA 308
Query: 351 HWRIKIETCKLLCFNAAIKCDYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGCYGLC 410
+ +E+ +LL + AA D + + +E M K + + IQ+ G G
Sbjct: 309 DMSLAMESARLLTWRAAWLKDQK--QPYTKEAAMAKLAASEAATLCSHQCIQILGGMGYV 366
Query: 411 STQTPLSHMWQVSRSLRINDTPDESLISQLGRLEIS 446
+ H R RI + + + S++ RL I+
Sbjct: 367 TDMAAERHY----RDARITEIYEGT--SEIQRLVIA 396
>CE09015 [I] KOG0139 Short-chain acyl-CoA dehydrogenase
Length = 427
Score = 54.3 bits (129), Expect = 4e-07
Identities = 54/222 (24%), Positives = 106/222 (47%), Gaps = 18/222 (8%)
Query: 162 VQVIDELVSNNMKSCLMVSERDVSGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKD 221
++ + L S+++ S +SE +GSDA ++T K +GD ++GTK +I +
Sbjct: 151 LKYLPRLCSDSLAS-FCISESG-AGSDAFALKTIAKRDGDHF-------LISGTKMWITN 201
Query: 222 AGDSDIWLVLCVTEFDEGNIYRKHTLCLVNRNDLPPNSTRIEPIETNEAI--GKFYEVQF 279
+G++ +++V D Y+ T +V R+ + ++ E I +V F
Sbjct: 202 SGEAQVFVVFA--NADPSQKYKGITCFIVERS---ADGLTVDKEEDKLGIRASSTCQVHF 256
Query: 280 KDCKVPLN-IIGERGEGYQILQMKSSVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSK 338
+ +V + I+GE G+GY+ + ++ ++ G+ Q + +R+ FG +
Sbjct: 257 DNVRVHKSAILGEYGKGYKYAIECLNAGRIAIGAQMIGLAQGCFDQTIPYLQQREQFGQR 316
Query: 339 LQKSEYFKFDLAHWRIKIETCKLLCFNAAIKCDYEGVKAARE 380
L + + +A R +IE +LL +NAA +Y G+ RE
Sbjct: 317 LIDFQGLQHQIAQARTEIEAARLLVYNAARMKEY-GIPYVRE 357
>7299576 [I] KOG0139 Short-chain acyl-CoA dehydrogenase
Length = 415
Score = 53.9 bits (128), Expect = 5e-07
Identities = 58/264 (21%), Positives = 113/264 (41%), Gaps = 19/264 (7%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
+GSDA TT K++GD +NGTK +I ++ ++ +V + ++ K
Sbjct: 161 NGSDAGAASTTAKLQGDSYQ-------INGTKAWISNSKEASGGIVFATVD---KSMKHK 210
Query: 245 HTLCLVNRNDLPPNSTRIEPIETNEAIGKFYEVQFKDCKVPLN-IIGERGEGYQILQMKS 303
+ D+P S + + ++ +D VP + ++G G+G++I
Sbjct: 211 GITAFLTPKDVPGLSIAKKESKMGMRATSTCQLVLEDVHVPRSRVLGAAGDGFKIAMQSL 270
Query: 304 SVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLC 363
++ + G+ Q +L L+ + +R FG L + + + LA ++E +LL
Sbjct: 271 DCGRIGIAAQATGIAQAALELAVDYSQKRVAFGKHLARLQLIQQKLADMATRVEISRLLT 330
Query: 364 FNAAIKCDYEGVKAAREEIGMVKAVTPKEISSLVDWSIQLHGCYGLCSTQTPLSHMWQVS 423
+ AA D G+ + E M K + + IQ+ G G +T P ++ +
Sbjct: 331 WRAAWLKD-NGLPITK-EAAMAKLHASESATFCAHQCIQILGGMGY-TTDLPAELYYRNA 387
Query: 424 RSLRINDTPDESLISQLGRLEISN 447
R I + S++ R+ I+N
Sbjct: 388 RVTEIYEG-----TSEIQRIVIAN 406
>Hs4501859 [I] KOG0139 Short-chain acyl-CoA dehydrogenase
Length = 432
Score = 51.6 bits (122), Expect = 2e-06
Identities = 53/224 (23%), Positives = 96/224 (42%), Gaps = 25/224 (11%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
+GSD+ ++T EGD LNG+K +I A + ++LV+ + G Y+
Sbjct: 181 AGSDSFALKTRADKEGD-------YYVLNGSKMWISSAEHAGLFLVMANVDPTIG--YKG 231
Query: 245 HTLCLVNRND------LPPNSTRIEPIETNEAIGKFYEVQFKDCKVP-LNIIGERGEGYQ 297
T LV+R+ P N + T + F++ KVP NI+G+ G GY+
Sbjct: 232 ITSFLVDRDTPGLHIGKPENKLGLRASST-------CPLTFENVKVPEANILGQIGHGYK 284
Query: 298 ILQMKSSVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIE 357
+ ++ ++ G+ Q + ER FG +L + + +AH ++E
Sbjct: 285 YAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLE 344
Query: 358 TCKLLCFNAA--IKCDYEGVKAAREEIGMVKAVTPKEISSLVDW 399
+LL +NAA ++ +K A + + S ++W
Sbjct: 345 AARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEW 388
>7293851 [I] KOG0139 Short-chain acyl-CoA dehydrogenase
Length = 414
Score = 51.6 bits (122), Expect = 2e-06
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 17/220 (7%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
+GSDA +++T K +G +NG+K +I ++ + ++L+ + ++G YR
Sbjct: 161 AGSDAFSLKTVAKKDGSHY-------VINGSKMWISNSDVAGVFLIFANAKPEDG--YRG 211
Query: 245 HTLCLVNRNDLPPNSTRIEPIETNEAIGKFYEVQFKDCKVPL-NIIGERGEGYQILQMKS 303
T +V+R + E A G ++ F + +VP NI+G G GY+
Sbjct: 212 ITTFIVDRETPGLIVNKPEDKLGIRASGTC-QLTFDNVRVPEENILGTFGHGYKYAAGFL 270
Query: 304 SVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKLLC 363
+ ++ ++ G+ Q + + ERK FG + + + +A +IE +L+
Sbjct: 271 NEGRIGIAAQMVGLAQGTFDATIPYLLERKQFGDAIYNFQSMQHQIATVATEIEAARLMT 330
Query: 364 FNAAIKCDYEGVKAAREEIGMVK----AVTPKEISSLVDW 399
+NAA + +GV ++E M K V + VDW
Sbjct: 331 YNAA-RLQEQGV-PFQKEAAMAKYYASEVAQRAAIKCVDW 368
>7295201 [I] KOG0140 Medium-chain acyl-CoA dehydrogenase
Length = 419
Score = 50.8 bits (120), Expect = 4e-06
Identities = 44/178 (24%), Positives = 76/178 (41%), Gaps = 8/178 (4%)
Query: 185 SGSDALNVQTTCKIEGDDLNEEEATMTLNGTKWFIKDAGDSDIWLVLCVTEFDEGNIYRK 244
+GSD ++T + +GD+ +NG K +I + G ++ + VL T D K
Sbjct: 161 AGSDVSGIKTRAEKKGDE-------WVINGQKMWITNGGVANWYFVLARTNPDPKCPPSK 213
Query: 245 HTLCLVNRNDLPPNSTRIEPIETNEAIGKFYEVQFKDCKVPL-NIIGERGEGYQILQMKS 303
+ D P + + + + + F+D +VP N++ G G++I
Sbjct: 214 AFTGFIVERDSPGLTPGRKELNMGQRASDTRGITFEDVRVPKENVLIGEGAGFKIAMGTF 273
Query: 304 SVTKLFQCLKLCGMGQESLRLSNKRAAERKVFGSKLQKSEYFKFDLAHWRIKIETCKL 361
T+ G+ Q L + K A ERK FG + + +F LA I +ET +L
Sbjct: 274 DKTRPPVAAGAVGLAQRCLDEALKYALERKTFGVPIAYHQAVQFMLADMAIGVETSRL 331
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,549,172
Number of Sequences: 60738
Number of extensions: 1226014
Number of successful extensions: 2698
Number of sequences better than 1.0e-05: 21
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2666
Number of HSP's gapped (non-prelim): 21
length of query: 465
length of database: 30,389,216
effective HSP length: 110
effective length of query: 355
effective length of database: 23,708,036
effective search space: 8416352780
effective search space used: 8416352780
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)