ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV4072 check: MH O KOG4412 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit PSMD10
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV4072 1407194 1406505 -230
(230 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGR232w [O] KOG4412 26S proteasome regulatory complex subunit PS... 217 1e-56
SPAC6C3.08 [O] KOG4412 26S proteasome regulatory complex subunit... 122 4e-28
At2g03430 [O] KOG4412 26S proteasome regulatory complex subunit ... 103 3e-22
Hs10947042 [M] KOG4177 Ankyrin 97 2e-20
Hs10947040 [M] KOG4177 Ankyrin 97 2e-20
Hs10947038 [M] KOG4177 Ankyrin 97 2e-20
Hs10947036 [M] KOG4177 Ankyrin 97 2e-20
Hs4506217 [O] KOG4412 26S proteasome regulatory complex subunit ... 94 2e-19
Hs4502093 [M] KOG4177 Ankyrin 92 5e-19
Hs10947056 [M] KOG4177 Ankyrin 92 5e-19
Hs10947054 [M] KOG4177 Ankyrin 89 5e-18
Hs10947052 [M] KOG4177 Ankyrin 89 5e-18
7304338 [M] KOG4177 Ankyrin 88 9e-18
CE06705 [M] KOG4177 Ankyrin 86 4e-17
CE06704 [M] KOG4177 Ankyrin 86 4e-17
CE06703 [M] KOG4177 Ankyrin 86 4e-17
CE06702 [M] KOG4177 Ankyrin 86 4e-17
7295202 [M] KOG4177 Ankyrin 84 1e-16
Hs10190676_2 [R] KOG0504 FOG: Ankyrin repeat 84 2e-16
7297920 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domai... 82 6e-16
Hs20538133 [R] KOG0504 FOG: Ankyrin repeat 79 4e-15
CE26238_1 [M] KOG4177 Ankyrin 79 4e-15
Hs22064845 [T] KOG0192 Tyrosine kinase specific for activated (G... 79 5e-15
CE19848_2 [R] KOG0504 FOG: Ankyrin repeat 79 7e-15
7294199_2 [R] KOG0504 FOG: Ankyrin repeat 78 9e-15
Hs18079216 [T] KOG0507 CASK-interacting adaptor protein (caskin)... 78 1e-14
Hs16076877 [R] KOG0504 FOG: Ankyrin repeat 77 2e-14
7301583 [R] KOG0504 FOG: Ankyrin repeat 77 2e-14
Hs13899329 [R] KOG0504 FOG: Ankyrin repeat 75 6e-14
7301689 [R] KOG0504 FOG: Ankyrin repeat 74 2e-13
Hs14731279 [R] KOG0504 FOG: Ankyrin repeat 74 2e-13
Hs14149803 [U] KOG2319 Vacuolar assembly/sorting protein VPS9 74 2e-13
Hs7657238 [R] KOG0504 FOG: Ankyrin repeat 73 3e-13
Hs16159328 [R] KOG0504 FOG: Ankyrin repeat 73 4e-13
Hs4885087 [R] KOG0504 FOG: Ankyrin repeat 72 5e-13
Hs13376842 [M] KOG4177 Ankyrin 72 8e-13
CE16523 [R] KOG0504 FOG: Ankyrin repeat 71 1e-12
Hs4505319 [OT] KOG0505 Myosin phosphatase regulatory subunit 71 1e-12
Hs14195601 [OT] KOG0505 Myosin phosphatase regulatory subunit 71 1e-12
Hs4507613 [M] KOG4177 Ankyrin 70 2e-12
Hs21264330_2 [R] KOG0504 FOG: Ankyrin repeat 70 2e-12
7301133 [T] KOG4369 RTK signaling protein MASK/UNC-44 70 2e-12
7291939 [R] KOG0510 Ankyrin repeat protein 69 4e-12
7301359 [M] KOG4177 Ankyrin 69 7e-12
7296936 [R] KOG0504 FOG: Ankyrin repeat 69 7e-12
Hs7705831 [R] KOG0504 FOG: Ankyrin repeat 68 9e-12
Hs6601590 [R] KOG0510 Ankyrin repeat protein 68 9e-12
Hs20543919 [R] KOG0504 FOG: Ankyrin repeat 68 9e-12
Hs18426879 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 68 9e-12
Hs18375637 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 68 9e-12
Hs18252778 [R] KOG0504 FOG: Ankyrin repeat 68 9e-12
Hs14738291 [R] KOG0504 FOG: Ankyrin repeat 68 9e-12
7298956 [R] KOG0510 Ankyrin repeat protein 67 2e-11
Hs13386462 [R] KOG0504 FOG: Ankyrin repeat 67 2e-11
7295200_2 [R] KOG0504 FOG: Ankyrin repeat 67 2e-11
Hs20556512 [T] KOG0507 CASK-interacting adaptor protein (caskin)... 66 4e-11
At1g05640 [R] KOG0504 FOG: Ankyrin repeat 66 4e-11
7298524_2 [R] KOG0504 FOG: Ankyrin repeat 66 5e-11
CE05333 [R] KOG0510 Ankyrin repeat protein 65 6e-11
7296976 [M] KOG4177 Ankyrin 65 6e-11
Hs14744423 [R] KOG0504 FOG: Ankyrin repeat 65 8e-11
Hs13540484 [R] KOG0504 FOG: Ankyrin repeat 65 8e-11
CE05814 [R] KOG0502 Integral membrane ankyrin-repeat protein Kid... 65 8e-11
Hs17864094 [R] KOG0508 Ankyrin repeat protein 65 1e-10
Hs14770818 [OT] KOG0505 Myosin phosphatase regulatory subunit 64 1e-10
CE23926 [T] KOG4369 RTK signaling protein MASK/UNC-44 64 1e-10
CE06305 [T] KOG4369 RTK signaling protein MASK/UNC-44 64 1e-10
7291279 [R] KOG0502 Integral membrane ankyrin-repeat protein Kid... 64 1e-10
Hs21314722 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 64 2e-10
At3g09890 [R] KOG0504 FOG: Ankyrin repeat 64 2e-10
SPAC2F7.10 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger do... 64 2e-10
Hs10863929_1 [M] KOG4177 Ankyrin 64 2e-10
At5g40160 [R] KOG0504 FOG: Ankyrin repeat 63 3e-10
At3g04710_1 [R] KOG0504 FOG: Ankyrin repeat 63 3e-10
Hs8923104 [R] KOG0504 FOG: Ankyrin repeat 63 4e-10
Hs10835177_2 [R] KOG0504 FOG: Ankyrin repeat 63 4e-10
Hs20557885 [R] KOG0504 FOG: Ankyrin repeat 62 5e-10
CE07175 [R] KOG0508 Ankyrin repeat protein 62 5e-10
7300995 [T] KOG0507 CASK-interacting adaptor protein (caskin) an... 62 5e-10
Hs13376003 [M] KOG4177 Ankyrin 62 7e-10
7295892 [M] KOG4177 Ankyrin 62 7e-10
At5g13530_3 [R] KOG0504 FOG: Ankyrin repeat 62 7e-10
Hs7705748 [T] KOG0192 Tyrosine kinase specific for activated (GT... 62 9e-10
Hs7662406 [R] KOG0504 FOG: Ankyrin repeat 62 9e-10
Hs4502753 [R] KOG0504 FOG: Ankyrin repeat 62 9e-10
Hs18561834 [M] KOG4177 Ankyrin 62 9e-10
Hs18254470 [R] KOG0504 FOG: Ankyrin repeat 62 9e-10
At2g31820 [R] KOG0504 FOG: Ankyrin repeat 62 9e-10
Hs20472035 [R] KOG0504 FOG: Ankyrin repeat 61 1e-09
Hs18254462 [R] KOG0504 FOG: Ankyrin repeat 61 1e-09
Hs17485543 [R] KOG0504 FOG: Ankyrin repeat 61 1e-09
At4g32500 [PT] KOG0498 K+-channel ERG and related proteins conta... 61 1e-09
Hs18551475 [R] KOG0504 FOG: Ankyrin repeat 60 2e-09
Hs17441942 [R] KOG0504 FOG: Ankyrin repeat 60 2e-09
7294194 [OT] KOG0505 Myosin phosphatase regulatory subunit 60 2e-09
Hs13249344 [T] KOG1217 Fibrillins and related proteins containin... 60 3e-09
At5g60070 [R] KOG0504 FOG: Ankyrin repeat 60 3e-09
7301132 [R] KOG0504 FOG: Ankyrin repeat 60 3e-09
7293882 [OT] KOG0505 Myosin phosphatase regulatory subunit 60 3e-09
YPL110c_2 [R] KOG0504 FOG: Ankyrin repeat 60 3e-09
Hs4758606 [T] KOG0195 Integrin-linked kinase 60 3e-09
Hs4758818 [T] KOG1217 Fibrillins and related proteins containing... 59 4e-09
At5g02620 [R] KOG0504 FOG: Ankyrin repeat 59 4e-09
CE24712 [KLO] KOG1037 NAD+ ADP-ribosyltransferase Parp required ... 59 6e-09
CE05185 [R] KOG0504 FOG: Ankyrin repeat 59 6e-09
Hs11968152_1 [R] KOG0504 FOG: Ankyrin repeat 59 6e-09
Hs4505317 [OT] KOG0505 Myosin phosphatase regulatory subunit 59 7e-09
Hs13631463 [R] KOG0504 FOG: Ankyrin repeat 59 7e-09
Hs12746412 [R] KOG0502 Integral membrane ankyrin-repeat protein ... 58 1e-08
At4g27780 [I] KOG0817 Acyl-CoA-binding protein 58 1e-08
At1g07710 [R] KOG0504 FOG: Ankyrin repeat 58 1e-08
Hs10092619 [R] KOG0504 FOG: Ankyrin repeat 58 1e-08
CE27723 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 58 1e-08
At5g61230 [R] KOG0504 FOG: Ankyrin repeat 58 1e-08
At2g26650 [PT] KOG0498 K+-channel ERG and related proteins conta... 58 1e-08
7301236 [T] KOG0507 CASK-interacting adaptor protein (caskin) an... 58 1e-08
7293339 [R] KOG0504 FOG: Ankyrin repeat 58 1e-08
Hs4557349_2 [R] KOG0504 FOG: Ankyrin repeat 58 1e-08
Hs7656961 [R] KOG0504 FOG: Ankyrin repeat 57 2e-08
CE16688 [R] KOG0504 FOG: Ankyrin repeat 57 2e-08
7298294 [R] KOG0504 FOG: Ankyrin repeat 57 2e-08
7295029 [R] KOG0510 Ankyrin repeat protein 57 2e-08
Hs22062923 [R] KOG0504 FOG: Ankyrin repeat 57 2e-08
CE21005 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domai... 57 2e-08
CE19676 [R] KOG0504 FOG: Ankyrin repeat 57 2e-08
Hs9506623 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger dom... 57 3e-08
Hs18571424 [R] KOG0510 Ankyrin repeat protein 57 3e-08
At5g53470 [I] KOG0817 Acyl-CoA-binding protein 57 3e-08
At2g25600 [PT] KOG0498 K+-channel ERG and related proteins conta... 57 3e-08
7302342 [R] KOG0508 Ankyrin repeat protein 57 3e-08
Hs20270347 [R] KOG0504 FOG: Ankyrin repeat 56 4e-08
Hs7705278_2 [R] KOG0504 FOG: Ankyrin repeat 56 4e-08
Hs19923223_2 [R] KOG0504 FOG: Ankyrin repeat 56 4e-08
YDR264c [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domai... 56 5e-08
Hs14764060 [R] KOG0508 Ankyrin repeat protein 56 5e-08
7296935 [R] KOG0504 FOG: Ankyrin repeat 56 5e-08
YMR068w [R] KOG0504 FOG: Ankyrin repeat 55 6e-08
Hs19718743 [T] KOG2209 Oxysterol-binding protein 55 6e-08
Hs19718741 [T] KOG2209 Oxysterol-binding protein 55 6e-08
YIL112w [R] KOG0504 FOG: Ankyrin repeat 55 8e-08
Hs14742395 [R] KOG0514 Ankyrin repeat protein 55 8e-08
CE27598 [R] KOG0504 FOG: Ankyrin repeat 55 8e-08
CE20486 [OT] KOG0505 Myosin phosphatase regulatory subunit 55 8e-08
At4g35450 [R] KOG0504 FOG: Ankyrin repeat 55 8e-08
7296403 [T] KOG0195 Integrin-linked kinase 55 8e-08
YOR034c [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domai... 55 1e-07
Hs22047757 [M] KOG4177 Ankyrin 55 1e-07
CE28127 [R] KOG0504 FOG: Ankyrin repeat 55 1e-07
At5g37500 [PT] KOG0498 K+-channel ERG and related proteins conta... 55 1e-07
At3g12360 [R] KOG0504 FOG: Ankyrin repeat 55 1e-07
7291960_1 [R] KOG0504 FOG: Ankyrin repeat 55 1e-07
Hs7706007 [R] KOG0504 FOG: Ankyrin repeat 54 1e-07
Hs6981364 [I] KOG0513 Ca2+-independent phospholipase A2 54 1e-07
Hs22064210 [R] KOG0504 FOG: Ankyrin repeat 54 1e-07
Hs20562143 [R] KOG0504 FOG: Ankyrin repeat 54 1e-07
Hs20561564 [I] KOG0513 Ca2+-independent phospholipase A2 54 1e-07
Hs14150037 [R] KOG0504 FOG: Ankyrin repeat 54 1e-07
7294864 [R] KOG0504 FOG: Ankyrin repeat 54 1e-07
HsM11545809 [M] KOG4177 Ankyrin 54 2e-07
Hs22060186 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger do... 54 2e-07
Hs21450703 [R] KOG0504 FOG: Ankyrin repeat 54 2e-07
Hs21314697 [M] KOG4177 Ankyrin 54 2e-07
Hs20543460 [R] KOG0504 FOG: Ankyrin repeat 54 2e-07
Hs14720884 [R] KOG0504 FOG: Ankyrin repeat 54 2e-07
Hs14149716 [OT] KOG0505 Myosin phosphatase regulatory subunit 54 2e-07
7294632_2 [R] KOG0504 FOG: Ankyrin repeat 54 2e-07
Hs7657265 [R] KOG0508 Ankyrin repeat protein 54 2e-07
Hs4758806 [R] KOG0504 FOG: Ankyrin repeat 54 2e-07
CE28922 [K] KOG0512 Fetal globin-inducing factor (contains ankyr... 54 2e-07
7290390 [T] KOG1217 Fibrillins and related proteins containing C... 54 2e-07
Hs18593188 [R] KOG0508 Ankyrin repeat protein 53 3e-07
Hs13129098 [R] KOG0504 FOG: Ankyrin repeat 53 3e-07
At4g03460 [R] KOG0504 FOG: Ankyrin repeat 53 3e-07
At2g14250 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger dom... 53 3e-07
7299952 [R] KOG0508 Ankyrin repeat protein 53 3e-07
Hs20548307_2 [R] KOG0504 FOG: Ankyrin repeat 53 3e-07
At5g07840 [R] KOG0504 FOG: Ankyrin repeat 53 4e-07
At4g03500 [R] KOG0504 FOG: Ankyrin repeat 53 4e-07
At3g04140 [R] KOG0504 FOG: Ankyrin repeat 53 4e-07
At1g03670 [R] KOG0504 FOG: Ankyrin repeat 53 4e-07
YGR233c_2 [R] KOG0504 FOG: Ankyrin repeat 53 4e-07
Hs22058625_1 [R] KOG0504 FOG: Ankyrin repeat 53 4e-07
Hs4557799 [T] KOG1217 Fibrillins and related proteins containing... 52 5e-07
Hs18640738 [R] KOG0504 FOG: Ankyrin repeat 52 5e-07
Hs18254474 [R] KOG0504 FOG: Ankyrin repeat 52 5e-07
Hs14249672 [OT] KOG0505 Myosin phosphatase regulatory subunit 52 5e-07
CE19706 [T] KOG0195 Integrin-linked kinase 52 5e-07
Hs22054847_2 [R] KOG0504 FOG: Ankyrin repeat 52 5e-07
Hs15718772_1 [R] KOG0504 FOG: Ankyrin repeat 52 5e-07
Hs4885643 [D] KOG0515 p53-interacting protein 53BP/ASPP contains... 52 7e-07
Hs13443014 [R] KOG0504 FOG: Ankyrin repeat 52 7e-07
At5g13300 [T] KOG0521 Putative GTPase activating proteins (GAPs) 52 7e-07
SPBP16F5.05c [R] KOG0504 FOG: Ankyrin repeat 52 9e-07
Hs4758156 [T] KOG0782 Predicted diacylglycerol kinase 52 9e-07
Hs18390335 [R] KOG0504 FOG: Ankyrin repeat 52 9e-07
CE28044 [OT] KOG0505 Myosin phosphatase regulatory subunit 52 9e-07
CE19874 [D] KOG0515 p53-interacting protein 53BP/ASPP contains a... 52 9e-07
CE11616 [OT] KOG0505 Myosin phosphatase regulatory subunit 52 9e-07
CE02585 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domai... 52 9e-07
7299262 [E] KOG0503 Asparaginase 52 9e-07
YIR033w [K] KOG3836 HLH transcription factor EBF/Olf-1 and relat... 51 1e-06
Hs14149971 [R] KOG0504 FOG: Ankyrin repeat 51 1e-06
Hs13375989 [R] KOG0504 FOG: Ankyrin repeat 51 1e-06
7304080 [R] KOG0504 FOG: Ankyrin repeat 51 1e-06
At5g20350 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger dom... 51 2e-06
At4g14390 [R] KOG0504 FOG: Ankyrin repeat 51 2e-06
Hs20478597 [O] KOG4412 26S proteasome regulatory complex subunit... 50 2e-06
CE08106 [T] KOG0507 CASK-interacting adaptor protein (caskin) an... 50 3e-06
At2g17390 [R] KOG0504 FOG: Ankyrin repeat 50 3e-06
7303116 [R] KOG0514 Ankyrin repeat protein 50 3e-06
YPL239w [R] KOG0504 FOG: Ankyrin repeat 50 3e-06
CE27420 [R] KOG0504 FOG: Ankyrin repeat 50 3e-06
At4g03470 [R] KOG0504 FOG: Ankyrin repeat 50 3e-06
At3g09550 [R] KOG0504 FOG: Ankyrin repeat 50 3e-06
7303699 [R] KOG0504 FOG: Ankyrin repeat 50 3e-06
7294202 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domai... 50 3e-06
Hs7706379 [R] KOG0504 FOG: Ankyrin repeat 49 4e-06
Hs22044723 [R] KOG0504 FOG: Ankyrin repeat 49 4e-06
At3g02850 [PT] KOG0498 K+-channel ERG and related proteins conta... 49 4e-06
7295521_2 [I] KOG0817 Acyl-CoA-binding protein 49 4e-06
Hs22059561 [R] KOG0504 FOG: Ankyrin repeat 49 6e-06
Hs18129634 [M] KOG4177 Ankyrin 49 6e-06
At5g51160 [R] KOG0504 FOG: Ankyrin repeat 49 6e-06
At5g50140 [R] KOG0504 FOG: Ankyrin repeat 49 6e-06
At4g03480 [R] KOG0504 FOG: Ankyrin repeat 49 6e-06
At1g60860 [T] KOG0521 Putative GTPase activating proteins (GAPs) 49 6e-06
Hs4502751 [R] KOG0504 FOG: Ankyrin repeat 49 8e-06
Hs22057484 [R] KOG0504 FOG: Ankyrin repeat 49 8e-06
7291268 [D] KOG0515 p53-interacting protein 53BP/ASPP contains a... 49 8e-06
At4g19150 [R] KOG0504 FOG: Ankyrin repeat 48 1e-05
At1g10340 [R] KOG0504 FOG: Ankyrin repeat 48 1e-05
SPAPB1E7.05_1 [R] KOG0504 FOG: Ankyrin repeat 48 1e-05
Hs22045770_1 [R] KOG0504 FOG: Ankyrin repeat 48 1e-05
>YGR232w [O] KOG4412 26S proteasome regulatory complex subunit PSMD10
Length = 228
Score = 217 bits (552), Expect = 1e-56
Identities = 108/228 (47%), Positives = 151/228 (65%), Gaps = 2/228 (0%)
Query: 3 ADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKK 62
+++ LH ACM + KVQ++L P + KD DGR PLHW+VSFQ I LLS M+
Sbjct: 2 SNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMEN 61
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
++LD D+SGW+P HIA S+G++ +++ L + ++P+L+ N G+T LHLA KK
Sbjct: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCD-KNSPVNIKDKNGWSPLFHA 181
V Q L+E GASVRIKD Q+PLHRAA+ GS+ ++ +LC S VN +DK GW+PLFHA
Sbjct: 122 VSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHA 181
Query: 182 LAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKICVDAKVKDYFLSKV 229
LAEGHGD AV LV KY A ++ DN + + ++ +VK +FL+ V
Sbjct: 182 LAEGHGDAAVLLVEKYGAEYD-LVDNKGAKAEDVALNEQVKKFFLNNV 228
>SPAC6C3.08 [O] KOG4412 26S proteasome regulatory complex subunit PSMD10
Length = 234
Score = 122 bits (306), Expect = 4e-28
Identities = 83/218 (38%), Positives = 120/218 (54%), Gaps = 10/218 (4%)
Query: 13 NGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDES 72
N E V+Q + P ++ DDD R PLHWA S + N I LL I D DE+
Sbjct: 13 NCPEEYVEQAIQNDPNSLNAVDDDKRTPLHWACSVGKVNTIYFLLK-QPNIKPDE-KDEA 70
Query: 73 GWSPVHIASSIGSV--TILEKLLNHT-VEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
GW+P+ I+ + SV ++E+L+N + V+P + + G T LH A K L++VQLL +
Sbjct: 71 GWTPLMISINNRSVPDNVIEELINRSDVDPTITTRG--GQTCLHYAAGKGRLSIVQLLCD 128
Query: 130 RGAS-VRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGD 188
+ +R KD GQ PLHRAAA G + +V L + +P+N D G++PL ALAEGH D
Sbjct: 129 KAPELIRKKDLQGQTPLHRAAAVGKIQVVKYLISQRAPLNTSDSYGFTPLHFALAEGHPD 188
Query: 189 VAVTLVNKYHALWEGETDNDDLSIDKICVDAKVKDYFL 226
V V LV +++N + ++C D V + FL
Sbjct: 189 VGVELVRAGADTLRKDSENH--TALEVCPDRIVCNEFL 224
>At2g03430 [O] KOG4412 26S proteasome regulatory complex subunit PSMD10
Length = 247
Score = 103 bits (256), Expect = 3e-22
Identities = 55/154 (35%), Positives = 88/154 (56%), Gaps = 2/154 (1%)
Query: 29 AVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTI 88
++ +++DGR LH A SF I+ +L S + + D+ GW+P+H A+SIG+ +
Sbjct: 39 SLNFRNEDGRSLLHVAASFGHSQIVKLLSSSDEAKTVINSKDDEGWAPLHSAASIGNAEL 98
Query: 89 LEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRA 148
+E LL + N + N G TALH A SK L + QLL+ GA + I D +G PLHRA
Sbjct: 99 VEVLLTRGADVNA--KNNGGRTALHYAASKGRLEIAQLLLTHGAKINITDKVGCTPLHRA 156
Query: 149 AASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
A+ G + + L ++ + ++ DK G + L H++
Sbjct: 157 ASVGKLEVCEFLIEEGAEIDATDKMGQTALMHSV 190
>Hs10947042 [M] KOG4177 Ankyrin
Length = 1719
Score = 97.1 bits (240), Expect = 2e-20
Identities = 62/188 (32%), Positives = 99/188 (51%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A NG ++ +IL + ++ K +G P+H A + + +LL Y +ID D
Sbjct: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-D 333
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
LD +P+H+A+ G + + LL+ +PN +A NG T LH+AC K H+ V++L
Sbjct: 334 ITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNS--RALNGFTPLHIACKKNHVRVMEL 389
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GAS+ G PLH A+ G + IV L + + N+ + +PL A GH
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449
Query: 187 GDVAVTLV 194
+VA L+
Sbjct: 450 TEVAKYLL 457
Score = 87.8 bits (216), Expect = 1e-17
Identities = 57/190 (30%), Positives = 90/190 (47%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G T V+ +L E + G PLH A ++ ++ +L+ ++K
Sbjct: 474 LHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAA---REGHVETVLALLEKEASQ 529
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ + G++P+H+A+ G V + E LL PN NG+T LH+A +L++V+L
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKL 587
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ RG S G PLH AA V + L N + G +PL A EGH
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Query: 187 GDVAVTLVNK 196
++ L++K
Sbjct: 648 AEMVALLLSK 657
Score = 87.4 bits (215), Expect = 1e-17
Identities = 68/224 (30%), Positives = 110/224 (48%), Gaps = 35/224 (15%)
Query: 18 KVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL------------ 65
+V + L E V +DG PL A+ +N++ L++Y K +
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 66 DT--------------ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
DT +L ++G++P+HIA+ ++ + + LLN N Q NGIT
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ--NGITP 242
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A + ++ +V+LL++RGA + K PLH AA +G V I IL D +P+ K
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 172 KNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKI 215
KNG SP+ H A+G V L+ +Y A + DD+++D +
Sbjct: 303 KNGLSPI-HMAAQGDHLDCVRLLLQYDA------EIDDITLDHL 339
Score = 83.2 bits (204), Expect = 3e-16
Identities = 57/216 (26%), Positives = 102/216 (46%), Gaps = 31/216 (14%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G E V+++++ + V + G PL+ A Q+N ++++ ++
Sbjct: 82 LHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAA---QENHLEVVKFLLENGANQ 137
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------EP 99
+ E G++P+ +A G ++ L+N+ +P
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
N D+ + G T LH+A ++LNV QLL+ RGASV G PLH A+ G+V +V +
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
Query: 160 LCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
L D+ + + K K+ +PL A GH ++ L++
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Score = 83.2 bits (204), Expect = 3e-16
Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + + + V+ +L G+ +G PLH A Q + LL Y + +
Sbjct: 573 LHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++ G +P+H+A+ G ++ LL+ NL ++ G+T LHL + H+ V +
Sbjct: 632 SV---QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS--GLTPLHLVAQEGHVPVADV 686
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ G V +G PLH A+ G++ +V L + VN K K G+SPL A +GH
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 187 GDVAVTLV 194
D+ L+
Sbjct: 747 TDIVTLLL 754
Score = 82.8 bits (203), Expect = 4e-16
Identities = 60/191 (31%), Positives = 93/191 (48%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A ++++LL ID
Sbjct: 342 LHVAAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI-TALHLACSKKHLNVVQ 125
T ESG +P+H+AS +G + I++ LL PN+ +N + T LH+A H V +
Sbjct: 401 T---ESGLTPLHVASFMGHLPIVKNLLQRGASPNV---SNVKVETPLHMAARAGHTEVAK 454
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
L++ A V K Q PLH AA G +V +L + N+ N+ G +PL A EG
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 186 HGDVAVTLVNK 196
H + + L+ K
Sbjct: 515 HVETVLALLEK 525
Score = 80.1 bits (196), Expect = 2e-15
Identities = 57/190 (30%), Positives = 94/190 (49%), Gaps = 8/190 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A E + +L ++ G+ + G PLH A ++ +LLS +L
Sbjct: 606 LHIAAKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++SG +P+H+ + G V + + L+ H V +D G T LH+A ++ +V+
Sbjct: 665 ---NKSGLTPLHLVAQEGHVPVADVLIKHGVM--VDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ A V K LG PLH+AA G IV++L + N +G +PL A+A+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL--AIAKRL 777
Query: 187 GDVAVTLVNK 196
G ++VT V K
Sbjct: 778 GYISVTDVLK 787
Score = 76.6 bits (187), Expect = 3e-14
Identities = 52/190 (27%), Positives = 93/190 (48%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A N DT +L P V G PLH A ++ N+ +LL+ ++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++G +P+HIAS G+V ++ LL+ + ++ + + +T LH A H+ + ++
Sbjct: 236 P---QNGITPLHIASRRGNVIMVRLLLDRGAQ--IETKTKDELTPLHCAARNGHVRISEI 290
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA ++ K G P+H AA + V +L ++ ++ + +PL A GH
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 187 GDVAVTLVNK 196
VA L++K
Sbjct: 351 HRVAKVLLDK 360
Score = 69.3 bits (168), Expect = 4e-12
Identities = 44/144 (30%), Positives = 80/144 (55%), Gaps = 4/144 (2%)
Query: 53 IDILLSYMKK-IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
+D L +++ +D++T +++G + +H+AS G V ++ +LL+ + L+ G TA
Sbjct: 25 LDKALDHLRNGVDINTC-NQNGLNGLHLASKEGHVKMVVELLHKEII--LETTTKKGNTA 81
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A VV+ LV GA+V + G PL+ AA + +V L + + N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 172 KNGWSPLFHALAEGHGDVAVTLVN 195
++G++PL AL +GH +V L+N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLIN 165
Score = 63.5 bits (153), Expect = 2e-10
Identities = 52/191 (27%), Positives = 89/191 (46%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G+ V+ +L GA ++ K D PLH A I +ILL + I
Sbjct: 243 LHIASRRGNVIMVRLLLDR--GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
T ++G SP+H+A+ + + LL + E +D + +T LH+A H V +
Sbjct: 301 KT---KNGLSPIHMAAQGDHLDCVRLLLQYDAE--IDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+L+++GA + G PLH A V ++ +L + ++ ++G +PL A G
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
Query: 186 HGDVAVTLVNK 196
H + L+ +
Sbjct: 416 HLPIVKNLLQR 426
>Hs10947040 [M] KOG4177 Ankyrin
Length = 1880
Score = 97.1 bits (240), Expect = 2e-20
Identities = 62/188 (32%), Positives = 99/188 (51%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A NG ++ +IL + ++ K +G P+H A + + +LL Y +ID D
Sbjct: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-D 333
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
LD +P+H+A+ G + + LL+ +PN +A NG T LH+AC K H+ V++L
Sbjct: 334 ITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNS--RALNGFTPLHIACKKNHVRVMEL 389
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GAS+ G PLH A+ G + IV L + + N+ + +PL A GH
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449
Query: 187 GDVAVTLV 194
+VA L+
Sbjct: 450 TEVAKYLL 457
Score = 87.8 bits (216), Expect = 1e-17
Identities = 57/190 (30%), Positives = 90/190 (47%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G T V+ +L E + G PLH A ++ ++ +L+ ++K
Sbjct: 474 LHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAA---REGHVETVLALLEKEASQ 529
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ + G++P+H+A+ G V + E LL PN NG+T LH+A +L++V+L
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKL 587
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ RG S G PLH AA V + L N + G +PL A EGH
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Query: 187 GDVAVTLVNK 196
++ L++K
Sbjct: 648 AEMVALLLSK 657
Score = 87.4 bits (215), Expect = 1e-17
Identities = 68/224 (30%), Positives = 110/224 (48%), Gaps = 35/224 (15%)
Query: 18 KVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL------------ 65
+V + L E V +DG PL A+ +N++ L++Y K +
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 66 DT--------------ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
DT +L ++G++P+HIA+ ++ + + LLN N Q NGIT
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ--NGITP 242
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A + ++ +V+LL++RGA + K PLH AA +G V I IL D +P+ K
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 172 KNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKI 215
KNG SP+ H A+G V L+ +Y A + DD+++D +
Sbjct: 303 KNGLSPI-HMAAQGDHLDCVRLLLQYDA------EIDDITLDHL 339
Score = 83.2 bits (204), Expect = 3e-16
Identities = 57/216 (26%), Positives = 102/216 (46%), Gaps = 31/216 (14%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G E V+++++ + V + G PL+ A Q+N ++++ ++
Sbjct: 82 LHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAA---QENHLEVVKFLLENGANQ 137
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------EP 99
+ E G++P+ +A G ++ L+N+ +P
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
N D+ + G T LH+A ++LNV QLL+ RGASV G PLH A+ G+V +V +
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
Query: 160 LCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
L D+ + + K K+ +PL A GH ++ L++
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Score = 83.2 bits (204), Expect = 3e-16
Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + + + V+ +L G+ +G PLH A Q + LL Y + +
Sbjct: 573 LHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++ G +P+H+A+ G ++ LL+ NL ++ G+T LHL + H+ V +
Sbjct: 632 SV---QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS--GLTPLHLVAQEGHVPVADV 686
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ G V +G PLH A+ G++ +V L + VN K K G+SPL A +GH
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 187 GDVAVTLV 194
D+ L+
Sbjct: 747 TDIVTLLL 754
Score = 82.8 bits (203), Expect = 4e-16
Identities = 60/191 (31%), Positives = 93/191 (48%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A ++++LL ID
Sbjct: 342 LHVAAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI-TALHLACSKKHLNVVQ 125
T ESG +P+H+AS +G + I++ LL PN+ +N + T LH+A H V +
Sbjct: 401 T---ESGLTPLHVASFMGHLPIVKNLLQRGASPNV---SNVKVETPLHMAARAGHTEVAK 454
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
L++ A V K Q PLH AA G +V +L + N+ N+ G +PL A EG
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 186 HGDVAVTLVNK 196
H + + L+ K
Sbjct: 515 HVETVLALLEK 525
Score = 80.1 bits (196), Expect = 2e-15
Identities = 57/190 (30%), Positives = 94/190 (49%), Gaps = 8/190 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A E + +L ++ G+ + G PLH A ++ +LLS +L
Sbjct: 606 LHIAAKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++SG +P+H+ + G V + + L+ H V +D G T LH+A ++ +V+
Sbjct: 665 ---NKSGLTPLHLVAQEGHVPVADVLIKHGVM--VDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ A V K LG PLH+AA G IV++L + N +G +PL A+A+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL--AIAKRL 777
Query: 187 GDVAVTLVNK 196
G ++VT V K
Sbjct: 778 GYISVTDVLK 787
Score = 76.6 bits (187), Expect = 3e-14
Identities = 52/190 (27%), Positives = 93/190 (48%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A N DT +L P V G PLH A ++ N+ +LL+ ++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++G +P+HIAS G+V ++ LL+ + ++ + + +T LH A H+ + ++
Sbjct: 236 P---QNGITPLHIASRRGNVIMVRLLLDRGAQ--IETKTKDELTPLHCAARNGHVRISEI 290
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA ++ K G P+H AA + V +L ++ ++ + +PL A GH
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 187 GDVAVTLVNK 196
VA L++K
Sbjct: 351 HRVAKVLLDK 360
Score = 69.3 bits (168), Expect = 4e-12
Identities = 44/144 (30%), Positives = 80/144 (55%), Gaps = 4/144 (2%)
Query: 53 IDILLSYMKK-IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
+D L +++ +D++T +++G + +H+AS G V ++ +LL+ + L+ G TA
Sbjct: 25 LDKALDHLRNGVDINTC-NQNGLNGLHLASKEGHVKMVVELLHKEII--LETTTKKGNTA 81
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A VV+ LV GA+V + G PL+ AA + +V L + + N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 172 KNGWSPLFHALAEGHGDVAVTLVN 195
++G++PL AL +GH +V L+N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLIN 165
Score = 63.5 bits (153), Expect = 2e-10
Identities = 52/191 (27%), Positives = 89/191 (46%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G+ V+ +L GA ++ K D PLH A I +ILL + I
Sbjct: 243 LHIASRRGNVIMVRLLLDR--GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
T ++G SP+H+A+ + + LL + E +D + +T LH+A H V +
Sbjct: 301 KT---KNGLSPIHMAAQGDHLDCVRLLLQYDAE--IDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+L+++GA + G PLH A V ++ +L + ++ ++G +PL A G
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
Query: 186 HGDVAVTLVNK 196
H + L+ +
Sbjct: 416 HLPIVKNLLQR 426
>Hs10947038 [M] KOG4177 Ankyrin
Length = 1881
Score = 97.1 bits (240), Expect = 2e-20
Identities = 62/188 (32%), Positives = 99/188 (51%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A NG ++ +IL + ++ K +G P+H A + + +LL Y +ID D
Sbjct: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-D 333
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
LD +P+H+A+ G + + LL+ +PN +A NG T LH+AC K H+ V++L
Sbjct: 334 ITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNS--RALNGFTPLHIACKKNHVRVMEL 389
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GAS+ G PLH A+ G + IV L + + N+ + +PL A GH
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449
Query: 187 GDVAVTLV 194
+VA L+
Sbjct: 450 TEVAKYLL 457
Score = 87.8 bits (216), Expect = 1e-17
Identities = 57/190 (30%), Positives = 90/190 (47%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G T V+ +L E + G PLH A ++ ++ +L+ ++K
Sbjct: 474 LHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAA---REGHVETVLALLEKEASQ 529
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ + G++P+H+A+ G V + E LL PN NG+T LH+A +L++V+L
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKL 587
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ RG S G PLH AA V + L N + G +PL A EGH
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Query: 187 GDVAVTLVNK 196
++ L++K
Sbjct: 648 AEMVALLLSK 657
Score = 87.4 bits (215), Expect = 1e-17
Identities = 68/224 (30%), Positives = 110/224 (48%), Gaps = 35/224 (15%)
Query: 18 KVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL------------ 65
+V + L E V +DG PL A+ +N++ L++Y K +
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 66 DT--------------ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
DT +L ++G++P+HIA+ ++ + + LLN N Q NGIT
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ--NGITP 242
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A + ++ +V+LL++RGA + K PLH AA +G V I IL D +P+ K
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 172 KNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKI 215
KNG SP+ H A+G V L+ +Y A + DD+++D +
Sbjct: 303 KNGLSPI-HMAAQGDHLDCVRLLLQYDA------EIDDITLDHL 339
Score = 83.2 bits (204), Expect = 3e-16
Identities = 57/216 (26%), Positives = 102/216 (46%), Gaps = 31/216 (14%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G E V+++++ + V + G PL+ A Q+N ++++ ++
Sbjct: 82 LHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAA---QENHLEVVKFLLENGANQ 137
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------EP 99
+ E G++P+ +A G ++ L+N+ +P
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
N D+ + G T LH+A ++LNV QLL+ RGASV G PLH A+ G+V +V +
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
Query: 160 LCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
L D+ + + K K+ +PL A GH ++ L++
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Score = 83.2 bits (204), Expect = 3e-16
Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + + + V+ +L G+ +G PLH A Q + LL Y + +
Sbjct: 573 LHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++ G +P+H+A+ G ++ LL+ NL ++ G+T LHL + H+ V +
Sbjct: 632 SV---QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS--GLTPLHLVAQEGHVPVADV 686
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ G V +G PLH A+ G++ +V L + VN K K G+SPL A +GH
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 187 GDVAVTLV 194
D+ L+
Sbjct: 747 TDIVTLLL 754
Score = 82.8 bits (203), Expect = 4e-16
Identities = 60/191 (31%), Positives = 93/191 (48%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A ++++LL ID
Sbjct: 342 LHVAAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI-TALHLACSKKHLNVVQ 125
T ESG +P+H+AS +G + I++ LL PN+ +N + T LH+A H V +
Sbjct: 401 T---ESGLTPLHVASFMGHLPIVKNLLQRGASPNV---SNVKVETPLHMAARAGHTEVAK 454
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
L++ A V K Q PLH AA G +V +L + N+ N+ G +PL A EG
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 186 HGDVAVTLVNK 196
H + + L+ K
Sbjct: 515 HVETVLALLEK 525
Score = 80.1 bits (196), Expect = 2e-15
Identities = 57/190 (30%), Positives = 94/190 (49%), Gaps = 8/190 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A E + +L ++ G+ + G PLH A ++ +LLS +L
Sbjct: 606 LHIAAKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++SG +P+H+ + G V + + L+ H V +D G T LH+A ++ +V+
Sbjct: 665 ---NKSGLTPLHLVAQEGHVPVADVLIKHGVM--VDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ A V K LG PLH+AA G IV++L + N +G +PL A+A+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL--AIAKRL 777
Query: 187 GDVAVTLVNK 196
G ++VT V K
Sbjct: 778 GYISVTDVLK 787
Score = 76.6 bits (187), Expect = 3e-14
Identities = 52/190 (27%), Positives = 93/190 (48%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A N DT +L P V G PLH A ++ N+ +LL+ ++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++G +P+HIAS G+V ++ LL+ + ++ + + +T LH A H+ + ++
Sbjct: 236 P---QNGITPLHIASRRGNVIMVRLLLDRGAQ--IETKTKDELTPLHCAARNGHVRISEI 290
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA ++ K G P+H AA + V +L ++ ++ + +PL A GH
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 187 GDVAVTLVNK 196
VA L++K
Sbjct: 351 HRVAKVLLDK 360
Score = 69.3 bits (168), Expect = 4e-12
Identities = 44/144 (30%), Positives = 80/144 (55%), Gaps = 4/144 (2%)
Query: 53 IDILLSYMKK-IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
+D L +++ +D++T +++G + +H+AS G V ++ +LL+ + L+ G TA
Sbjct: 25 LDKALDHLRNGVDINTC-NQNGLNGLHLASKEGHVKMVVELLHKEII--LETTTKKGNTA 81
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A VV+ LV GA+V + G PL+ AA + +V L + + N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 172 KNGWSPLFHALAEGHGDVAVTLVN 195
++G++PL AL +GH +V L+N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLIN 165
Score = 63.5 bits (153), Expect = 2e-10
Identities = 52/191 (27%), Positives = 89/191 (46%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G+ V+ +L GA ++ K D PLH A I +ILL + I
Sbjct: 243 LHIASRRGNVIMVRLLLDR--GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
T ++G SP+H+A+ + + LL + E +D + +T LH+A H V +
Sbjct: 301 KT---KNGLSPIHMAAQGDHLDCVRLLLQYDAE--IDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+L+++GA + G PLH A V ++ +L + ++ ++G +PL A G
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
Query: 186 HGDVAVTLVNK 196
H + L+ +
Sbjct: 416 HLPIVKNLLQR 426
>Hs10947036 [M] KOG4177 Ankyrin
Length = 1856
Score = 97.1 bits (240), Expect = 2e-20
Identities = 62/188 (32%), Positives = 99/188 (51%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A NG ++ +IL + ++ K +G P+H A + + +LL Y +ID D
Sbjct: 276 LHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID-D 333
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
LD +P+H+A+ G + + LL+ +PN +A NG T LH+AC K H+ V++L
Sbjct: 334 ITLDHL--TPLHVAAHCGHHRVAKVLLDKGAKPNS--RALNGFTPLHIACKKNHVRVMEL 389
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GAS+ G PLH A+ G + IV L + + N+ + +PL A GH
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGH 449
Query: 187 GDVAVTLV 194
+VA L+
Sbjct: 450 TEVAKYLL 457
Score = 87.8 bits (216), Expect = 1e-17
Identities = 57/190 (30%), Positives = 90/190 (47%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G T V+ +L E + G PLH A ++ ++ +L+ ++K
Sbjct: 474 LHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAA---REGHVETVLALLEKEASQ 529
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ + G++P+H+A+ G V + E LL PN NG+T LH+A +L++V+L
Sbjct: 530 ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKL 587
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ RG S G PLH AA V + L N + G +PL A EGH
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Query: 187 GDVAVTLVNK 196
++ L++K
Sbjct: 648 AEMVALLLSK 657
Score = 87.4 bits (215), Expect = 1e-17
Identities = 68/224 (30%), Positives = 110/224 (48%), Gaps = 35/224 (15%)
Query: 18 KVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL------------ 65
+V + L E V +DG PL A+ +N++ L++Y K +
Sbjct: 125 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARND 184
Query: 66 DT--------------ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
DT +L ++G++P+HIA+ ++ + + LLN N Q NGIT
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ--NGITP 242
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A + ++ +V+LL++RGA + K PLH AA +G V I IL D +P+ K
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 172 KNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKI 215
KNG SP+ H A+G V L+ +Y A + DD+++D +
Sbjct: 303 KNGLSPI-HMAAQGDHLDCVRLLLQYDA------EIDDITLDHL 339
Score = 83.2 bits (204), Expect = 3e-16
Identities = 57/216 (26%), Positives = 102/216 (46%), Gaps = 31/216 (14%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G E V+++++ + V + G PL+ A Q+N ++++ ++
Sbjct: 82 LHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAA---QENHLEVVKFLLENGANQ 137
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------EP 99
+ E G++P+ +A G ++ L+N+ +P
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
N D+ + G T LH+A ++LNV QLL+ RGASV G PLH A+ G+V +V +
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 257
Query: 160 LCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
L D+ + + K K+ +PL A GH ++ L++
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Score = 83.2 bits (204), Expect = 3e-16
Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + + + V+ +L G+ +G PLH A Q + LL Y + +
Sbjct: 573 LHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++ G +P+H+A+ G ++ LL+ NL ++ G+T LHL + H+ V +
Sbjct: 632 SV---QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS--GLTPLHLVAQEGHVPVADV 686
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ G V +G PLH A+ G++ +V L + VN K K G+SPL A +GH
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 187 GDVAVTLV 194
D+ L+
Sbjct: 747 TDIVTLLL 754
Score = 82.8 bits (203), Expect = 4e-16
Identities = 60/191 (31%), Positives = 93/191 (48%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A ++++LL ID
Sbjct: 342 LHVAAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI-TALHLACSKKHLNVVQ 125
T ESG +P+H+AS +G + I++ LL PN+ +N + T LH+A H V +
Sbjct: 401 T---ESGLTPLHVASFMGHLPIVKNLLQRGASPNV---SNVKVETPLHMAARAGHTEVAK 454
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
L++ A V K Q PLH AA G +V +L + N+ N+ G +PL A EG
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 186 HGDVAVTLVNK 196
H + + L+ K
Sbjct: 515 HVETVLALLEK 525
Score = 80.1 bits (196), Expect = 2e-15
Identities = 57/190 (30%), Positives = 94/190 (49%), Gaps = 8/190 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A E + +L ++ G+ + G PLH A ++ +LLS +L
Sbjct: 606 LHIAAKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++SG +P+H+ + G V + + L+ H V +D G T LH+A ++ +V+
Sbjct: 665 ---NKSGLTPLHLVAQEGHVPVADVLIKHGVM--VDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ A V K LG PLH+AA G IV++L + N +G +PL A+A+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL--AIAKRL 777
Query: 187 GDVAVTLVNK 196
G ++VT V K
Sbjct: 778 GYISVTDVLK 787
Score = 76.6 bits (187), Expect = 3e-14
Identities = 52/190 (27%), Positives = 93/190 (48%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A N DT +L P V G PLH A ++ N+ +LL+ ++
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNP-DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++G +P+HIAS G+V ++ LL+ + ++ + + +T LH A H+ + ++
Sbjct: 236 P---QNGITPLHIASRRGNVIMVRLLLDRGAQ--IETKTKDELTPLHCAARNGHVRISEI 290
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA ++ K G P+H AA + V +L ++ ++ + +PL A GH
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 187 GDVAVTLVNK 196
VA L++K
Sbjct: 351 HRVAKVLLDK 360
Score = 69.3 bits (168), Expect = 4e-12
Identities = 44/144 (30%), Positives = 80/144 (55%), Gaps = 4/144 (2%)
Query: 53 IDILLSYMKK-IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
+D L +++ +D++T +++G + +H+AS G V ++ +LL+ + L+ G TA
Sbjct: 25 LDKALDHLRNGVDINTC-NQNGLNGLHLASKEGHVKMVVELLHKEII--LETTTKKGNTA 81
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A VV+ LV GA+V + G PL+ AA + +V L + + N+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 172 KNGWSPLFHALAEGHGDVAVTLVN 195
++G++PL AL +GH +V L+N
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLIN 165
Score = 63.5 bits (153), Expect = 2e-10
Identities = 52/191 (27%), Positives = 89/191 (46%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G+ V+ +L GA ++ K D PLH A I +ILL + I
Sbjct: 243 LHIASRRGNVIMVRLLLDR--GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 300
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
T ++G SP+H+A+ + + LL + E +D + +T LH+A H V +
Sbjct: 301 KT---KNGLSPIHMAAQGDHLDCVRLLLQYDAE--IDDITLDHLTPLHVAAHCGHHRVAK 355
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+L+++GA + G PLH A V ++ +L + ++ ++G +PL A G
Sbjct: 356 VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMG 415
Query: 186 HGDVAVTLVNK 196
H + L+ +
Sbjct: 416 HLPIVKNLLQR 426
>Hs4506217 [O] KOG4412 26S proteasome regulatory complex subunit PSMD10
Length = 226
Score = 93.6 bits (231), Expect = 2e-19
Identities = 64/203 (31%), Positives = 102/203 (49%), Gaps = 6/203 (2%)
Query: 13 NGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDES 72
+G E++++ + D D R LHWA S I++ LL ++ D++
Sbjct: 16 SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK---DDA 72
Query: 73 GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGA 132
GWSP+HIA+S G I++ LL + N Q NG T LH A SK + +L+E GA
Sbjct: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQ--NGCTPLHYAASKNRHEIAVMLLEGGA 130
Query: 133 SVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVT 192
+ KD +HRAAA G++ ++ IL + NI+D G +PL A E + A
Sbjct: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKL 190
Query: 193 LVNKYHALW-EGETDNDDLSIDK 214
LV++ +++ E + + L + K
Sbjct: 191 LVSQGASIYIENKEEKTPLQVAK 213
Score = 75.1 bits (183), Expect = 8e-14
Identities = 55/172 (31%), Positives = 87/172 (49%), Gaps = 6/172 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC G TE V+ +L + V KDD G PLH A S +D I+ LL +++
Sbjct: 44 LHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN-- 100
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++++G +P+H A+S I LL P D + + TA+H A +K +L ++ +
Sbjct: 101 -AVNQNGCTPLHYAASKNRHEIAVMLLEGGANP--DAKDHYEATAMHRAAAKGNLKMIHI 157
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
L+ AS I+D G PLH A V +L + + + I++K +PL
Sbjct: 158 LLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPL 209
>Hs4502093 [M] KOG4177 Ankyrin
Length = 1088
Score = 92.4 bits (228), Expect = 5e-19
Identities = 61/188 (32%), Positives = 95/188 (50%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + D +KV +L + + +G PLH A Q +I LL Y +
Sbjct: 223 LHVAA-HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 281
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T G + VH+A+ G V ++ LL N++L +G+T LHLA + +NV ++
Sbjct: 282 T---RQGIASVHLAAQEGHVDMVSLLLGRNA--NVNLSNKSGLTPLHLAAQEDRVNVAEV 336
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LV +GA V + +G PLH G++ IV+ L ++ VN K KNG++PL A +GH
Sbjct: 337 LVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGH 396
Query: 187 GDVAVTLV 194
+ L+
Sbjct: 397 THIINVLL 404
Score = 89.0 bits (219), Expect = 5e-18
Identities = 56/160 (35%), Positives = 84/160 (52%), Gaps = 5/160 (3%)
Query: 36 DGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNH 95
+G PLH A + ++++LL + I T ESG +P+H+A+ +G V I+ +L++H
Sbjct: 20 NGFTPLHIACKKNRIKVMELLLKHGASIQAVT---ESGLTPIHVAAFMGHVNIVSQLMHH 76
Query: 96 TVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVG 155
PN G TALH+A VV+ LV+ GA V K Q PLH +A G
Sbjct: 77 GASPNTTNV--RGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 134
Query: 156 IVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
IV L + + N +G++PL + EGH DVA L++
Sbjct: 135 IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD 174
Score = 84.3 bits (207), Expect = 1e-16
Identities = 57/190 (30%), Positives = 92/190 (48%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH + G E V L + ++ + G PLH A + + + ++LL D
Sbjct: 157 LHLSAREGH-EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA- 214
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+SG +P+H+A+ + + LL+ P+ A NG T LH+A K +++
Sbjct: 215 --AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA--AAKNGYTPLHIAAKKNQMDIATT 270
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E GA G +H AA G V +VS+L +N+ VN+ +K+G +PL A E
Sbjct: 271 LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDR 330
Query: 187 GDVAVTLVNK 196
+VA LVN+
Sbjct: 331 VNVAEVLVNQ 340
Score = 73.9 bits (180), Expect = 2e-13
Identities = 52/192 (27%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 7 LHAACMNGDTEKVQQILSE--FPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID 64
+H A G V Q++ P V+ G LH A Q ++ L+ +++
Sbjct: 58 IHVAAFMGHVNIVSQLMHHGASPNTTNVR---GETALHMAARSGQAEVVRYLVQDGAQVE 114
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
D++ P+HI++ +G I+++LL PN +G T LHL+ + H +V
Sbjct: 115 AKAKDDQT---PLHISARLGKADIVQQLLQQGASPNA--ATTSGYTPLHLSAREGHEDVA 169
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
L++ GAS+ I G PLH AA G + + ++L K++ + K+G +PL A
Sbjct: 170 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 229
Query: 185 GHGDVAVTLVNK 196
+ VA+ L+++
Sbjct: 230 DNQKVALLLLDQ 241
Score = 72.0 bits (175), Expect = 6e-13
Identities = 54/196 (27%), Positives = 86/196 (43%), Gaps = 15/196 (7%)
Query: 8 HAACMNGDTE----------KVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILL 57
HAA NG T + L E+ G +H A +++ +LL
Sbjct: 246 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 305
Query: 58 SYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACS 117
++L ++SG +P+H+A+ V + E L+N ++D Q G T LH+ C
Sbjct: 306 GRNANVNLS---NKSGLTPLHLAAQEDRVNVAEVLVNQGA--HVDAQTKMGYTPLHVGCH 360
Query: 118 KKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSP 177
++ +V L++ A V K G PLH+AA G I+++L N+ N NG +
Sbjct: 361 YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 420
Query: 178 LFHALAEGHGDVAVTL 193
L A G+ V TL
Sbjct: 421 LGIARRLGYISVVDTL 436
Score = 67.0 bits (162), Expect = 2e-11
Identities = 37/125 (29%), Positives = 63/125 (49%), Gaps = 2/125 (1%)
Query: 72 SGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERG 131
+G++P+HIA + ++E LL H ++ +G+T +H+A H+N+V L+ G
Sbjct: 20 NGFTPLHIACKKNRIKVMELLLKHGA--SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 77
Query: 132 ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAV 191
AS + G+ LH AA SG +V L + V K K+ +PL + G D+
Sbjct: 78 ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 137
Query: 192 TLVNK 196
L+ +
Sbjct: 138 QLLQQ 142
Score = 61.6 bits (148), Expect = 9e-10
Identities = 38/103 (36%), Positives = 53/103 (50%), Gaps = 2/103 (1%)
Query: 92 LLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAAS 151
LL+ PN +A NG T LH+AC K + V++LL++ GAS++ G P+H AA
Sbjct: 7 LLDKKANPNA--KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 64
Query: 152 GSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
G V IVS L + N + G + L A G +V LV
Sbjct: 65 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLV 107
>Hs10947056 [M] KOG4177 Ankyrin
Length = 4377
Score = 92.4 bits (228), Expect = 5e-19
Identities = 61/188 (32%), Positives = 95/188 (50%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + D +KV +L + + +G PLH A Q +I LL Y +
Sbjct: 602 LHVAA-HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T G + VH+A+ G V ++ LL N++L +G+T LHLA + +NV ++
Sbjct: 661 T---RQGIASVHLAAQEGHVDMVSLLLGRNA--NVNLSNKSGLTPLHLAAQEDRVNVAEV 715
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LV +GA V + +G PLH G++ IV+ L ++ VN K KNG++PL A +GH
Sbjct: 716 LVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGH 775
Query: 187 GDVAVTLV 194
+ L+
Sbjct: 776 THIINVLL 783
Score = 92.4 bits (228), Expect = 5e-19
Identities = 64/189 (33%), Positives = 95/189 (49%), Gaps = 6/189 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G KV ++L + K +G PLH A + ++++LL + I
Sbjct: 371 LHVAAHCGHY-KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T ESG +P+H+A+ +G V I+ +L++H PN G TALH+A VV+
Sbjct: 430 T---ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNV--RGETALHMAARSGQAEVVRY 484
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LV+ GA V K Q PLH +A G IV L + + N +G++PL + EGH
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
Query: 187 GDVAVTLVN 195
DVA L++
Sbjct: 545 EDVAAFLLD 553
Score = 86.7 bits (213), Expect = 3e-17
Identities = 62/191 (32%), Positives = 94/191 (48%), Gaps = 10/191 (5%)
Query: 41 LHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN 100
LH A +LL D+++ +SG++P+HIA+ G++ + LLN
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVES---KSGFTPLHIAAHYGNINVATLLLNRAAA-- 260
Query: 101 LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
+D A N IT LH+A + + N+V+LL++RGA + K G PLH A SG +V +L
Sbjct: 261 VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320
Query: 161 CDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLS---IDKICV 217
D+ +P+ K KNG SPL A H + L+ H + + ND L+ + C
Sbjct: 321 LDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ--HNVPVDDVTNDYLTALHVAAHCG 378
Query: 218 DAKVKDYFLSK 228
KV L K
Sbjct: 379 HYKVAKVLLDK 389
Score = 84.3 bits (207), Expect = 1e-16
Identities = 57/190 (30%), Positives = 92/190 (48%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH + G E V L + ++ + G PLH A + + + ++LL D
Sbjct: 536 LHLSAREGH-EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA- 593
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+SG +P+H+A+ + + LL+ P+ A NG T LH+A K +++
Sbjct: 594 --AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA--AAKNGYTPLHIAAKKNQMDIATT 649
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E GA G +H AA G V +VS+L +N+ VN+ +K+G +PL A E
Sbjct: 650 LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDR 709
Query: 187 GDVAVTLVNK 196
+VA LVN+
Sbjct: 710 VNVAEVLVNQ 719
Score = 84.0 bits (206), Expect = 2e-16
Identities = 57/188 (30%), Positives = 93/188 (49%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH +G E+V ++L + + K +G PLH A N + +LL + + +D
Sbjct: 305 LHCGARSGH-EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH--NVPVD 361
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ ++ + +H+A+ G + + LL+ PN +A NG T LH+AC K + V++L
Sbjct: 362 DVTNDY-LTALHVAAHCGHYKVAKVLLDKKANPNA--KALNGFTPLHIACKKNRIKVMEL 418
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GAS++ G P+H AA G V IVS L + N + G + L A G
Sbjct: 419 LLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQ 478
Query: 187 GDVAVTLV 194
+V LV
Sbjct: 479 AEVVRYLV 486
Score = 75.1 bits (183), Expect = 8e-14
Identities = 46/139 (33%), Positives = 77/139 (55%), Gaps = 4/139 (2%)
Query: 57 LSYMKK-IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLA 115
L Y+K +D++ I +++G + +H+AS G V ++ +LL E N+D G TALH+A
Sbjct: 58 LDYIKNGVDIN-ICNQNGLNALHLASKEGHVEVVSELLQR--EANVDAATKKGNTALHIA 114
Query: 116 CSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGW 175
VV++LV GA+V + G PL+ AA + +V L D + ++ ++G+
Sbjct: 115 SLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGF 174
Query: 176 SPLFHALAEGHGDVAVTLV 194
+PL AL +GH V L+
Sbjct: 175 TPLAVALQQGHDQVVSLLL 193
Score = 73.9 bits (180), Expect = 2e-13
Identities = 52/192 (27%), Positives = 92/192 (47%), Gaps = 10/192 (5%)
Query: 7 LHAACMNGDTEKVQQILSE--FPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID 64
+H A G V Q++ P V+ G LH A Q ++ L+ +++
Sbjct: 437 IHVAAFMGHVNIVSQLMHHGASPNTTNVR---GETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
D++ P+HI++ +G I+++LL PN +G T LHL+ + H +V
Sbjct: 494 AKAKDDQT---PLHISARLGKADIVQQLLQQGASPNA--ATTSGYTPLHLSAREGHEDVA 548
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
L++ GAS+ I G PLH AA G + + ++L K++ + K+G +PL A
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608
Query: 185 GHGDVAVTLVNK 196
+ VA+ L+++
Sbjct: 609 DNQKVALLLLDQ 620
Score = 72.8 bits (177), Expect = 4e-13
Identities = 62/232 (26%), Positives = 100/232 (42%), Gaps = 29/232 (12%)
Query: 8 HAACMNGDTE----------KVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILL 57
HAA NG T + L E+ G +H A +++ +LL
Sbjct: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
Query: 58 SYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACS 117
++L ++SG +P+H+A+ V + E L+N ++D Q G T LH+ C
Sbjct: 685 GRNANVNLS---NKSGLTPLHLAAQEDRVNVAEVLVNQGA--HVDAQTKMGYTPLHVGCH 739
Query: 118 KKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSP 177
++ +V L++ A V K G PLH+AA G I+++L N+ N NG +
Sbjct: 740 YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799
Query: 178 LFHALAEGHGDVAVTL------------VNKYHALWEGETDND--DLSIDKI 215
L A G+ V TL V + H + ET N+ D+S D++
Sbjct: 800 LGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEV 851
Score = 68.9 bits (167), Expect = 5e-12
Identities = 60/201 (29%), Positives = 91/201 (44%), Gaps = 7/201 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+ V +L AV + PLH A N++ +LL KID
Sbjct: 239 LHIAAHYGNIN-VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAK 297
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T G +P+H + G ++E LL+ P L + NG++ LH+A HLN VQL
Sbjct: 298 T---RDGLTPLHCGARSGHEQVVEMLLDRAA-PILS-KTKNGLSPLHMATQGDHLNCVQL 352
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ V LH AA G + +L DK + N K NG++PL H + +
Sbjct: 353 LLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPL-HIACKKN 411
Query: 187 GDVAVTLVNKYHALWEGETDN 207
+ L+ K+ A + T++
Sbjct: 412 RIKVMELLLKHGASIQAVTES 432
Score = 63.9 bits (154), Expect = 2e-10
Identities = 37/109 (33%), Positives = 62/109 (55%), Gaps = 3/109 (2%)
Query: 89 LEKLLNHTVEPNLDLQA--NNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLH 146
LEK L++ ++ +D+ NG+ ALHLA + H+ VV L++R A+V G LH
Sbjct: 54 LEKALDY-IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALH 112
Query: 147 RAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
A+ +G +V +L + VN + +NG++PL+ A E H +V L++
Sbjct: 113 IASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161
Score = 62.0 bits (149), Expect = 7e-10
Identities = 45/191 (23%), Positives = 93/191 (48%), Gaps = 12/191 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A + G E V+ +++ GA V + +G PL+ A Q+N ++++ +
Sbjct: 111 LHIASLAGQAEVVKVLVTN--GANVNAQSQNGFTPLYMAA---QENHLEVVKFLLDNGAS 165
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
++ E G++P+ +A G ++ LL + D + + ALH+A K
Sbjct: 166 QSLATEDGFTPLAVALQQGHDQVVSLLLEN------DTKGKVRLPALHIAARKDDTKAAA 219
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL++ + ++ G PLH AA G++ + ++L ++ + V+ +N +PL A G
Sbjct: 220 LLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRG 279
Query: 186 HGDVAVTLVNK 196
+ ++ L+++
Sbjct: 280 NANMVKLLLDR 290
Score = 61.2 bits (147), Expect = 1e-09
Identities = 49/200 (24%), Positives = 91/200 (45%), Gaps = 34/200 (17%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
+ + + +G LH A ++ LL +D T + G + +HIAS G ++
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAAT---KKGNTALHIASLAGQAEVV 123
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGAS-------------VRI 136
+ L+ + N++ Q+ NG T L++A + HL VV+ L++ GAS V +
Sbjct: 124 KVLVTNGA--NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181
Query: 137 KDGLGQL----------------PLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFH 180
+ G Q+ LH AA ++L ++ +++ K+G++PL
Sbjct: 182 QQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHI 241
Query: 181 ALAEGHGDVAVTLVNKYHAL 200
A G+ +VA L+N+ A+
Sbjct: 242 AAHYGNINVATLLLNRAAAV 261
>Hs10947054 [M] KOG4177 Ankyrin
Length = 1872
Score = 89.0 bits (219), Expect = 5e-18
Identities = 60/188 (31%), Positives = 95/188 (49%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + D +KV +L E + +G PLH A Q I LL+Y + ++
Sbjct: 600 LHVAA-HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T + G +P+H+AS G ++ LL+ N+ + +G+T+LHLA + +NV +
Sbjct: 659 T---KQGVTPLHLASQEGHTDMVTLLLDKGA--NIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L + GA LG PL A G+V +V+ L + + VN K KNG++PL A +GH
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 187 GDVAVTLV 194
+ L+
Sbjct: 774 THIINVLL 781
Score = 87.0 bits (214), Expect = 2e-17
Identities = 48/115 (41%), Positives = 71/115 (61%), Gaps = 3/115 (2%)
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
ESG++P+HIA+ G+V + LLN +D A NGIT LH+A + + N+V+LL++R
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAA--VDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 131 GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
G + K G PLH AA SG +V +L ++ +P+ + KNG SPL H A+G
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL-HMAAQG 342
Score = 86.3 bits (212), Expect = 3e-17
Identities = 64/192 (33%), Positives = 91/192 (47%), Gaps = 10/192 (5%)
Query: 7 LHAACMNGDTEKVQQILSEF--PGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID 64
LH A G TE VQ +L P A +G PLH + Q ++ +LL
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATT---NGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
L T + G++P+H+A+ GS+ + + LL D NG+T LH+A + V
Sbjct: 558 LAT---KKGFTPLHVAAKYGSLDVAKLLLQRRAAA--DSAGKNGLTPLHVAAHYDNQKVA 612
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
LL+E+GAS G PLH AA + I S L + + NI K G +PL A E
Sbjct: 613 LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672
Query: 185 GHGDVAVTLVNK 196
GH D+ L++K
Sbjct: 673 GHTDMVTLLLDK 684
Score = 79.3 bits (194), Expect = 4e-15
Identities = 56/188 (29%), Positives = 92/188 (48%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A +G ++V ++L E + + +G PLH A + LL + +D D
Sbjct: 303 LHCAARSGH-DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD-D 360
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
LD + +H+A+ G + + LL+ PN +A NG T LH+AC K + V++L
Sbjct: 361 VTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNA--RALNGFTPLHIACKKNRIKVMEL 416
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LV+ GAS++ G P+H AA G + IV +L + ++ + G + L A G
Sbjct: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476
Query: 187 GDVAVTLV 194
+V L+
Sbjct: 477 VEVVRCLL 484
Score = 77.4 bits (189), Expect = 2e-14
Identities = 58/188 (30%), Positives = 92/188 (48%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A + ++++L+ Y I
Sbjct: 369 LHVAAHCGHY-RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T ESG +P+H+A+ +G + I+ LL + P D+ G TALH+A + VV+
Sbjct: 428 T---ESGLTPIHVAAFMGHLNIVLLLLQNGASP--DVTNIRGETALHMAARAGQVEVVRC 482
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ GA V + Q PLH A+ G IV +L + + NG++PL + EG
Sbjct: 483 LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 542
Query: 187 GDVAVTLV 194
DVA L+
Sbjct: 543 VDVASVLL 550
Score = 73.9 bits (180), Expect = 2e-13
Identities = 58/197 (29%), Positives = 90/197 (45%), Gaps = 12/197 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-------VKVKDDDGRYPLHWAVSFQQDNIIDILLSY 59
LH A DT+ +L A V + G PLH A + N+ +LL+
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 60 MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKK 119
+D +G +P+H+AS G+ +++ LL+ + +D + +G+T LH A
Sbjct: 256 GAAVDFTA---RNGITPLHVASKRGNTNMVKLLLDRGGQ--IDAKTRDGLTPLHCAARSG 310
Query: 120 HLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLF 179
H VV+LL+ERGA + + G PLH AA V V L +PV+ + + L
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370
Query: 180 HALAEGHGDVAVTLVNK 196
A GH V L++K
Sbjct: 371 VAAHCGHYRVTKLLLDK 387
Score = 73.2 bits (178), Expect = 3e-13
Identities = 54/190 (28%), Positives = 90/190 (46%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC KV ++L ++ +++ + G P+H A NI+ +LL D+
Sbjct: 402 LHIACKKNRI-KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
I E+ +H+A+ G V ++ LL + +D +A T LH+A +VQL
Sbjct: 461 NIRGETA---LHMAARAGQVEVVRCLLRNGAL--VDARAREEQTPLHIASRLGKTEIVQL 515
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ A G PLH +A G V + S+L + + ++ K G++PL A G
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 187 GDVAVTLVNK 196
DVA L+ +
Sbjct: 576 LDVAKLLLQR 585
Score = 69.7 bits (169), Expect = 3e-12
Identities = 58/226 (25%), Positives = 99/226 (43%), Gaps = 41/226 (18%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A + G E V+ ++ E GA + + +G PL+ A Q+N ID++ ++
Sbjct: 101 LHIASLAGQAEVVKVLVKE--GANINAQSQNGFTPLYMAA---QENHIDVVKYLLENGAN 155
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------E 98
+ E G++P+ +A G + LL + +
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215
Query: 99 PNLDLQAN--------NGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAA 150
N D+Q+ +G T LH+A ++NV LL+ RGA+V G PLH A+
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275
Query: 151 SGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
G+ +V +L D+ ++ K ++G +PL A GH V L+ +
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Score = 68.9 bits (167), Expect = 5e-12
Identities = 44/145 (30%), Positives = 82/145 (56%), Gaps = 5/145 (3%)
Query: 53 IDILLSYMKK-IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
+D ++ Y+K ID++T +++G + +H+A+ G V ++++LL ++D G TA
Sbjct: 44 LDKVVEYLKGGIDINTC-NQNGLNALHLAAKEGHVGLVQELLGRG--SSVDSATKKGNTA 100
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A VV++LV+ GA++ + G PL+ AA + +V L + + +
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 172 KNGWSPLFHALAEGHGD-VAVTLVN 195
++G++PL AL +GH VA+ L N
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLEN 185
Score = 55.1 bits (131), Expect = 8e-08
Identities = 43/163 (26%), Positives = 77/163 (46%), Gaps = 10/163 (6%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVK--DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDT 67
A G+ +KV + L G + + + +G LH A ++ LL +D T
Sbjct: 38 AARAGNLDKVVEYLK---GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
+ G + +HIAS G +++ L+ N++ Q+ NG T L++A + H++VV+ L
Sbjct: 95 ---KKGNTALHIASLAGQAEVVKVLVKEGA--NINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK 170
+E GA+ G PL A G V+IL + ++ ++
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
>Hs10947052 [M] KOG4177 Ankyrin
Length = 3957
Score = 89.0 bits (219), Expect = 5e-18
Identities = 60/188 (31%), Positives = 95/188 (49%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + D +KV +L E + +G PLH A Q I LL+Y + ++
Sbjct: 600 LHVAA-HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T + G +P+H+AS G ++ LL+ N+ + +G+T+LHLA + +NV +
Sbjct: 659 T---KQGVTPLHLASQEGHTDMVTLLLDKGA--NIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L + GA LG PL A G+V +V+ L + + VN K KNG++PL A +GH
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 187 GDVAVTLV 194
+ L+
Sbjct: 774 THIINVLL 781
Score = 87.0 bits (214), Expect = 2e-17
Identities = 48/115 (41%), Positives = 71/115 (61%), Gaps = 3/115 (2%)
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
ESG++P+HIA+ G+V + LLN +D A NGIT LH+A + + N+V+LL++R
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAA--VDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 131 GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
G + K G PLH AA SG +V +L ++ +P+ + KNG SPL H A+G
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL-HMAAQG 342
Score = 86.3 bits (212), Expect = 3e-17
Identities = 64/192 (33%), Positives = 91/192 (47%), Gaps = 10/192 (5%)
Query: 7 LHAACMNGDTEKVQQILSEF--PGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID 64
LH A G TE VQ +L P A +G PLH + Q ++ +LL
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATT---NGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
L T + G++P+H+A+ GS+ + + LL D NG+T LH+A + V
Sbjct: 558 LAT---KKGFTPLHVAAKYGSLDVAKLLLQRRAAA--DSAGKNGLTPLHVAAHYDNQKVA 612
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
LL+E+GAS G PLH AA + I S L + + NI K G +PL A E
Sbjct: 613 LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672
Query: 185 GHGDVAVTLVNK 196
GH D+ L++K
Sbjct: 673 GHTDMVTLLLDK 684
Score = 79.3 bits (194), Expect = 4e-15
Identities = 56/188 (29%), Positives = 92/188 (48%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A +G ++V ++L E + + +G PLH A + LL + +D D
Sbjct: 303 LHCAARSGH-DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD-D 360
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
LD + +H+A+ G + + LL+ PN +A NG T LH+AC K + V++L
Sbjct: 361 VTLDYL--TALHVAAHCGHYRVTKLLLDKRANPNA--RALNGFTPLHIACKKNRIKVMEL 416
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LV+ GAS++ G P+H AA G + IV +L + ++ + G + L A G
Sbjct: 417 LVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQ 476
Query: 187 GDVAVTLV 194
+V L+
Sbjct: 477 VEVVRCLL 484
Score = 77.4 bits (189), Expect = 2e-14
Identities = 58/188 (30%), Positives = 92/188 (48%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A + ++++L+ Y I
Sbjct: 369 LHVAAHCGHY-RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T ESG +P+H+A+ +G + I+ LL + P D+ G TALH+A + VV+
Sbjct: 428 T---ESGLTPIHVAAFMGHLNIVLLLLQNGASP--DVTNIRGETALHMAARAGQVEVVRC 482
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ GA V + Q PLH A+ G IV +L + + NG++PL + EG
Sbjct: 483 LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 542
Query: 187 GDVAVTLV 194
DVA L+
Sbjct: 543 VDVASVLL 550
Score = 73.9 bits (180), Expect = 2e-13
Identities = 58/197 (29%), Positives = 90/197 (45%), Gaps = 12/197 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-------VKVKDDDGRYPLHWAVSFQQDNIIDILLSY 59
LH A DT+ +L A V + G PLH A + N+ +LL+
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 60 MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKK 119
+D +G +P+H+AS G+ +++ LL+ + +D + +G+T LH A
Sbjct: 256 GAAVDFTA---RNGITPLHVASKRGNTNMVKLLLDRGGQ--IDAKTRDGLTPLHCAARSG 310
Query: 120 HLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLF 179
H VV+LL+ERGA + + G PLH AA V V L +PV+ + + L
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370
Query: 180 HALAEGHGDVAVTLVNK 196
A GH V L++K
Sbjct: 371 VAAHCGHYRVTKLLLDK 387
Score = 73.2 bits (178), Expect = 3e-13
Identities = 54/190 (28%), Positives = 90/190 (46%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC KV ++L ++ +++ + G P+H A NI+ +LL D+
Sbjct: 402 LHIACKKNRI-KVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
I E+ +H+A+ G V ++ LL + +D +A T LH+A +VQL
Sbjct: 461 NIRGETA---LHMAARAGQVEVVRCLLRNGAL--VDARAREEQTPLHIASRLGKTEIVQL 515
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ A G PLH +A G V + S+L + + ++ K G++PL A G
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 187 GDVAVTLVNK 196
DVA L+ +
Sbjct: 576 LDVAKLLLQR 585
Score = 69.7 bits (169), Expect = 3e-12
Identities = 58/226 (25%), Positives = 99/226 (43%), Gaps = 41/226 (18%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A + G E V+ ++ E GA + + +G PL+ A Q+N ID++ ++
Sbjct: 101 LHIASLAGQAEVVKVLVKE--GANINAQSQNGFTPLYMAA---QENHIDVVKYLLENGAN 155
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------E 98
+ E G++P+ +A G + LL + +
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215
Query: 99 PNLDLQAN--------NGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAA 150
N D+Q+ +G T LH+A ++NV LL+ RGA+V G PLH A+
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275
Query: 151 SGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
G+ +V +L D+ ++ K ++G +PL A GH V L+ +
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Score = 68.9 bits (167), Expect = 5e-12
Identities = 44/145 (30%), Positives = 82/145 (56%), Gaps = 5/145 (3%)
Query: 53 IDILLSYMKK-IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
+D ++ Y+K ID++T +++G + +H+A+ G V ++++LL ++D G TA
Sbjct: 44 LDKVVEYLKGGIDINTC-NQNGLNALHLAAKEGHVGLVQELLGRG--SSVDSATKKGNTA 100
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A VV++LV+ GA++ + G PL+ AA + +V L + + +
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 172 KNGWSPLFHALAEGHGD-VAVTLVN 195
++G++PL AL +GH VA+ L N
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLEN 185
Score = 55.1 bits (131), Expect = 8e-08
Identities = 43/163 (26%), Positives = 77/163 (46%), Gaps = 10/163 (6%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVK--DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDT 67
A G+ +KV + L G + + + +G LH A ++ LL +D T
Sbjct: 38 AARAGNLDKVVEYLK---GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 94
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
+ G + +HIAS G +++ L+ N++ Q+ NG T L++A + H++VV+ L
Sbjct: 95 ---KKGNTALHIASLAGQAEVVKVLVKEGA--NINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK 170
+E GA+ G PL A G V+IL + ++ ++
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
>7304338 [M] KOG4177 Ankyrin
Length = 1526
Score = 88.2 bits (217), Expect = 9e-18
Identities = 69/206 (33%), Positives = 102/206 (49%), Gaps = 18/206 (8%)
Query: 9 AACMNGDTEKVQQILSEFPGAVKVKDDDGRYP-LHWAVSFQQDNIIDILLSYMKKIDLDT 67
A M +K+ +L E KV R P LH A N +LL + D
Sbjct: 154 AVAMQQGHDKIVAVLLENDVRGKV-----RLPALHIAAKKNDVNAAKLLLQHDPNAD--- 205
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
I+ +SG++P+HIA+ G+V I LLN+ + N A + IT LH+AC L++ LL
Sbjct: 206 IVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNY--VAKHNITPLHVACKWGKLSLCTLL 263
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHG 187
+ RGA + G PLH A+ SG V ++ L +N+P+ K KNG S L H A+G
Sbjct: 264 LCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSAL-HMAAQGEH 322
Query: 188 DVAVTLVNKYHALWEGETDNDDLSID 213
D A H L + + D++++D
Sbjct: 323 DEAA------HLLLDNKAPVDEVTVD 342
Score = 87.4 bits (215), Expect = 1e-17
Identities = 59/210 (28%), Positives = 102/210 (48%), Gaps = 34/210 (16%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSY------- 59
LH AC G + V QIL + ++ + + PLH A + +I+++LL
Sbjct: 544 LHLACKYGK-QNVVQILLQNGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLC 602
Query: 60 -----------MKKIDLD------------TILDESGWSPVHIASSIGSVTILEKLLNHT 96
KK L+ I+ +SG+SP+H+A+ G+V +++ LL +
Sbjct: 603 ARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYG 662
Query: 97 VEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGI 156
V + A NG+T LH+A + H+ V Q+L+E GA++ + G PLH AA G + +
Sbjct: 663 V---ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDL 719
Query: 157 VSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
V + ++ + + G++PL A +GH
Sbjct: 720 VKFFIENDADIEMSSNIGYTPLHQAAQQGH 749
Score = 83.2 bits (204), Expect = 3e-16
Identities = 52/183 (28%), Positives = 87/183 (47%), Gaps = 6/183 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A +G E ++ +L + + K +G LH A + D +LL +D
Sbjct: 281 LHCASRSGHVEVIKHLLQQ-NAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEV 339
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+ + +H+A+ G V + + LL++ PN +A NG T LH+AC K + +V+L
Sbjct: 340 TV---DYLTALHVAAHCGHVKVAKLLLDYKANPNA--RALNGFTPLHIACKKNRIKMVEL 394
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA++ G PLH A+ G + IV L + ++ G +PL A
Sbjct: 395 LIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQ 454
Query: 187 GDV 189
D+
Sbjct: 455 ADI 457
Score = 81.6 bits (200), Expect = 8e-16
Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 9/188 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
+H AC E Q+L GA V + G PLH A +++ +LL Y +
Sbjct: 610 IHIACKKNYLEIAMQLLQH--GADVNIISKSGFSPLHLAAQGGNVDMVQLLLEY----GV 663
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
+ ++G +P+H+A+ G V + + LL H N+ + NG T LH+A HL++V+
Sbjct: 664 ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGA--NISERTRNGYTPLHMAAHYGHLDLVK 721
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+E A + + +G PLH+AA G + I+++L + N K+G + L A G
Sbjct: 722 FFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLG 781
Query: 186 HGDVAVTL 193
+ V +L
Sbjct: 782 YVTVMESL 789
Score = 76.3 bits (186), Expect = 3e-14
Identities = 53/191 (27%), Positives = 95/191 (48%), Gaps = 7/191 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+ + +L + + + +D LH A Q+NI+ +LL + +
Sbjct: 478 LHVASRLGNINIIMLLL-QHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAE---N 533
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ + G++P+H+A G +++ LL + ++D Q N +T LH+A + ++V+L
Sbjct: 534 NAVTKKGFTPLHLACKYGKQNVVQILLQNGA--SIDFQGKNDVTPLHVATHYNNPSIVEL 591
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ G+S + GQ +H A + I L + VNI K+G+SPL H A+G
Sbjct: 592 LLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPL-HLAAQGG 650
Query: 187 GDVAVTLVNKY 197
V L+ +Y
Sbjct: 651 NVDMVQLLLEY 661
Score = 75.9 bits (185), Expect = 4e-14
Identities = 59/207 (28%), Positives = 93/207 (44%), Gaps = 8/207 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC + V+ +L + + + G PLH A NI+ LL + DL
Sbjct: 380 LHIACKKNRIKMVE-LLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLP 438
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
TI E+ P+H+A+ I+ LL +D A G T LH+A ++N++ L
Sbjct: 439 TIRGET---PLHLAARANQADIIRILLRSA---KVDAIAREGQTPLHVASRLGNINIIML 492
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA + + LH AA G IV +L + + N K G++PL A G
Sbjct: 493 LLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGK 552
Query: 187 GDVA-VTLVNKYHALWEGETDNDDLSI 212
+V + L N ++G+ D L +
Sbjct: 553 QNVVQILLQNGASIDFQGKNDVTPLHV 579
Score = 60.5 bits (145), Expect = 2e-09
Identities = 50/189 (26%), Positives = 85/189 (44%), Gaps = 6/189 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A D + +L P A + G PLH A + +I +LL+ K D++
Sbjct: 182 LHIAAKKNDVNAAKLLLQHDPNA-DIVSKSGFTPLHIAAHYGNVDIATLLLN--NKADVN 238
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ + +P+H+A G +++ LL + +D +G+T LH A H+ V++
Sbjct: 239 YVAKHN-ITPLHVACKWGKLSLCTLLLCRGAK--IDAATRDGLTPLHCASRSGHVEVIKH 295
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+++ A + K G LH AA +L D +PV+ + + L A GH
Sbjct: 296 LLQQNAPILTKTKNGLSALHMAAQGEHDEAAHLLLDNKAPVDEVTVDYLTALHVAAHCGH 355
Query: 187 GDVAVTLVN 195
VA L++
Sbjct: 356 VKVAKLLLD 364
Score = 55.8 bits (133), Expect = 5e-08
Identities = 55/217 (25%), Positives = 94/217 (42%), Gaps = 37/217 (17%)
Query: 10 ACMNGDTEKVQQILSEFP-GAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKK-IDLDT 67
A +GD +KV L + + +G LH A +D +DI +++ I +D
Sbjct: 22 AARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAA---KDGYVDICCELLRRGIKIDN 78
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
+ G + +HIAS G ++ +L+ + N+++Q+ NG T L++A + H N + L
Sbjct: 79 AT-KKGNTALHIASLAGQHDVINQLILYNA--NVNVQSLNGFTPLYMAAQENHDNCCRTL 135
Query: 128 VERGA--SVRIKDGLGQL---------------------------PLHRAAASGSVGIVS 158
+ GA S+ +DG L LH AA V
Sbjct: 136 LANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAK 195
Query: 159 ILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
+L + +I K+G++PL A G+ D+A L+N
Sbjct: 196 LLLQHDPNADIVSKSGFTPLHIAAHYGNVDIATLLLN 232
>CE06705 [M] KOG4177 Ankyrin
Length = 1815
Score = 85.9 bits (211), Expect = 4e-17
Identities = 61/210 (29%), Positives = 100/210 (47%), Gaps = 8/210 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+T+ V +L + D PLH A Q+ + ILL +
Sbjct: 495 LHIASRLGNTDIVILLLQAGANS-NATTRDNYSPLHIAAKEGQEEVAGILLDHNAD---K 550
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+L + G++P+H+AS G++ ++ LL +D++ N +T LH+A + V L
Sbjct: 551 TLLTKKGFTPLHLASKYGNLEVVRLLLERGTP--VDIEGKNQVTPLHVAAHYNNDKVAML 608
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E GAS + G PLH AA + I S L + N K + G++PL + EGH
Sbjct: 609 LLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGH 668
Query: 187 GDVAVTLVNKYHALWEGETDNDDLSIDKIC 216
+++ L+ + G N+ L+ +C
Sbjct: 669 KEISGLLIENGSDV--GAKANNGLTAMHLC 696
Score = 85.1 bits (209), Expect = 7e-17
Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + + +KV +L E + K +G PLH A Q I LL + K D +
Sbjct: 594 LHVAA-HYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQF--KADPN 650
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+G++P+H+++ G I L+ + + + +ANNG+TA+HL + H+ V Q+
Sbjct: 651 A-KSRAGFTPLHLSAQEGHKEISGLLIENGSD--VGAKANNGLTAMHLCAQEDHVPVAQI 707
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L GA + K G PLH A G + +V L + + V K + ++PL A +GH
Sbjct: 708 LYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGH 767
Query: 187 GD 188
+
Sbjct: 768 NN 769
Score = 84.7 bits (208), Expect = 1e-16
Identities = 59/189 (31%), Positives = 96/189 (50%), Gaps = 6/189 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A + ++++LL Y I+
Sbjct: 363 LHVAAHCGHV-RVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEAT 421
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T ESG +P+H+A+ +G++ I+ LL P D++ G T LHLA +VV++
Sbjct: 422 T---ESGLTPLHVAAFMGAINIVIYLLQQGANP--DVETVRGETPLHLAARANQTDVVRV 476
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ GA V + Q PLH A+ G+ IV +L + N ++ +SPL A EG
Sbjct: 477 LIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQ 536
Query: 187 GDVAVTLVN 195
+VA L++
Sbjct: 537 EEVAGILLD 545
Score = 83.6 bits (205), Expect = 2e-16
Identities = 58/189 (30%), Positives = 95/189 (49%), Gaps = 8/189 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A +G + V ++ + GA + K +G PLH A + LL + +D
Sbjct: 297 LHCAARSGHDQVVDLLVVQ--GAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVD- 353
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
D +D +P+H+A+ G V + + LL+ + +PN +A NG T LH+AC K + VV+
Sbjct: 354 DVTVDYL--TPLHVAAHCGHVRVAKLLLDRSADPNS--RALNGFTPLHIACKKNRIKVVE 409
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL++ A++ G PLH AA G++ IV L + + +++ G +PL A
Sbjct: 410 LLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARAN 469
Query: 186 HGDVAVTLV 194
DV L+
Sbjct: 470 QTDVVRVLI 478
Score = 75.9 bits (185), Expect = 4e-14
Identities = 54/190 (28%), Positives = 91/190 (47%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC KV ++L ++ A++ + G PLH A NI+ LL D++
Sbjct: 396 LHIACKKNRI-KVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVE 454
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+ E+ P+H+A+ ++ L+ + + +D QA T LH+A + ++V L
Sbjct: 455 TVRGET---PLHLAARANQTDVVRVLIRNGAK--VDAQARELQTPLHIASRLGNTDIVIL 509
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA+ PLH AA G + IL D N+ + K G++PL A G+
Sbjct: 510 LLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGN 569
Query: 187 GDVAVTLVNK 196
+V L+ +
Sbjct: 570 LEVVRLLLER 579
Score = 73.2 bits (178), Expect = 3e-13
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+ E V+ +L E V ++ + PLH A + D + +LL
Sbjct: 561 LHLASKYGNLEVVRLLL-ERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAA 619
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++G++P+HIA+ + I LL +PN +A G T LHL+ + H + L
Sbjct: 620 A---KNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRA--GFTPLHLSAQEGHKEISGL 674
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E G+ V K G +H A V + IL + + +N K G++PL A G
Sbjct: 675 LIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQ 734
Query: 187 GDVAVTLV 194
++ LV
Sbjct: 735 LNMVKFLV 742
Score = 68.9 bits (167), Expect = 5e-12
Identities = 73/269 (27%), Positives = 108/269 (40%), Gaps = 75/269 (27%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G + + IL E V V+ +G PL+ A + ++ LL + L
Sbjct: 103 LHIASLAGQS-LIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALS 161
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------EP 99
T E G++P+ +A G ++ LL + E
Sbjct: 162 T---EDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEH 218
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASV------------------------- 134
N D+ + +G T LH+A H NV QLL+E+GA+V
Sbjct: 219 NPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANL 278
Query: 135 ----------RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
R KD L PLH AA SG +V +L + +P++ K KNG +PL A
Sbjct: 279 LLSRGAIIDSRTKDLL--TPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQG 336
Query: 185 GHGDVAVTLVNKYHALWEGETDNDDLSID 213
H D A TL+ YH DD+++D
Sbjct: 337 DHVDAARTLL--YH-----RAPVDDVTVD 358
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/187 (28%), Positives = 78/187 (40%), Gaps = 6/187 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A E + L +F K G PLH + I +L+ +
Sbjct: 627 LHIAAKKNQME-IASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAK 685
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+G + +H+ + V + + L N+ E N + N G T LH+AC LN+V+
Sbjct: 686 A---NNGLTAMHLCAQEDHVPVAQILYNNGAEINS--KTNAGYTPLHVACHFGQLNMVKF 740
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LVE GA V K PLH+AA G V L + + N + G +PL A G+
Sbjct: 741 LVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGY 800
Query: 187 GDVAVTL 193
V TL
Sbjct: 801 VSVVETL 807
Score = 63.9 bits (154), Expect = 2e-10
Identities = 62/234 (26%), Positives = 94/234 (39%), Gaps = 40/234 (17%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A DT +L V G PLH A + +N+ +LL ++
Sbjct: 198 LHIAAKKDDTTAATLLLQNEHNP-DVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQ 256
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
SP+H+A+ G + LL+ +D + + +T LH A H VV L
Sbjct: 257 A---RHNISPLHVATKWGRTNMANLLLSRGAI--IDSRTKDLLTPLHCAARSGHDQVVDL 311
Query: 127 LVERGA--SVRIKDGLGQL-------------------------------PLHRAAASGS 153
LV +GA S + K+GL L PLH AA G
Sbjct: 312 LVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGH 371
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDN 207
V + +L D+++ N + NG++PL H + + V L+ KY A E T++
Sbjct: 372 VRVAKLLLDRSADPNSRALNGFTPL-HIACKKNRIKVVELLLKYRAAIEATTES 424
Score = 62.0 bits (149), Expect = 7e-10
Identities = 38/108 (35%), Positives = 60/108 (55%), Gaps = 3/108 (2%)
Query: 89 LEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLH 146
LEK+L + D+ +N G+ +LHLA + H VV+ L++R A V G LH
Sbjct: 46 LEKVLE-LLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALH 104
Query: 147 RAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
A+ +G IV+IL + + VN++ NG++PL+ A E H +V L+
Sbjct: 105 IASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLL 152
Score = 61.2 bits (147), Expect = 1e-09
Identities = 51/191 (26%), Positives = 86/191 (44%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAV-KVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G T +LS GA+ + D PLH A D ++D+L+ I
Sbjct: 264 LHVATKWGRTNMANLLLSR--GAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISA 321
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
T ++G +P+H+A+ V LL H +D + +T LH+A H+ V +
Sbjct: 322 KT---KNGLAPLHMAAQGDHVDAARTLLYHRAP--VDDVTVDYLTPLHVAAHCGHVRVAK 376
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL++R A + G PLH A + +V +L + + ++G +PL A G
Sbjct: 377 LLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMG 436
Query: 186 HGDVAVTLVNK 196
++ + L+ +
Sbjct: 437 AINIVIYLLQQ 447
Score = 60.1 bits (144), Expect = 3e-09
Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
A GD EKV ++L + + +G LH A ++ L+ ++D T
Sbjct: 40 AARAGDLEKVLELLRAGTD-INTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAAT-- 96
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
G + +HIAS G I+ L+ + N+++Q+ NG T L++A + H VV+ L++
Sbjct: 97 -RKGNTALHIASLAGQSLIVTILVENGA--NVNVQSVNGFTPLYMAAQENHEEVVKYLLK 153
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
GA+ + G PL A G +V++L + +S ++ P H A+
Sbjct: 154 HGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVR-----LPALHIAAKKDDTT 208
Query: 190 AVTLV 194
A TL+
Sbjct: 209 AATLL 213
>CE06704 [M] KOG4177 Ankyrin
Length = 1867
Score = 85.9 bits (211), Expect = 4e-17
Identities = 61/210 (29%), Positives = 100/210 (47%), Gaps = 8/210 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+T+ V +L + D PLH A Q+ + ILL +
Sbjct: 495 LHIASRLGNTDIVILLLQAGANS-NATTRDNYSPLHIAAKEGQEEVAGILLDHNAD---K 550
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+L + G++P+H+AS G++ ++ LL +D++ N +T LH+A + V L
Sbjct: 551 TLLTKKGFTPLHLASKYGNLEVVRLLLERGTP--VDIEGKNQVTPLHVAAHYNNDKVAML 608
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E GAS + G PLH AA + I S L + N K + G++PL + EGH
Sbjct: 609 LLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGH 668
Query: 187 GDVAVTLVNKYHALWEGETDNDDLSIDKIC 216
+++ L+ + G N+ L+ +C
Sbjct: 669 KEISGLLIENGSDV--GAKANNGLTAMHLC 696
Score = 85.1 bits (209), Expect = 7e-17
Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + + +KV +L E + K +G PLH A Q I LL + K D +
Sbjct: 594 LHVAA-HYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQF--KADPN 650
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+G++P+H+++ G I L+ + + + +ANNG+TA+HL + H+ V Q+
Sbjct: 651 A-KSRAGFTPLHLSAQEGHKEISGLLIENGSD--VGAKANNGLTAMHLCAQEDHVPVAQI 707
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L GA + K G PLH A G + +V L + + V K + ++PL A +GH
Sbjct: 708 LYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGH 767
Query: 187 GD 188
+
Sbjct: 768 NN 769
Score = 84.7 bits (208), Expect = 1e-16
Identities = 59/189 (31%), Positives = 96/189 (50%), Gaps = 6/189 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A + ++++LL Y I+
Sbjct: 363 LHVAAHCGHV-RVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEAT 421
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T ESG +P+H+A+ +G++ I+ LL P D++ G T LHLA +VV++
Sbjct: 422 T---ESGLTPLHVAAFMGAINIVIYLLQQGANP--DVETVRGETPLHLAARANQTDVVRV 476
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ GA V + Q PLH A+ G+ IV +L + N ++ +SPL A EG
Sbjct: 477 LIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQ 536
Query: 187 GDVAVTLVN 195
+VA L++
Sbjct: 537 EEVAGILLD 545
Score = 83.6 bits (205), Expect = 2e-16
Identities = 58/189 (30%), Positives = 95/189 (49%), Gaps = 8/189 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A +G + V ++ + GA + K +G PLH A + LL + +D
Sbjct: 297 LHCAARSGHDQVVDLLVVQ--GAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVD- 353
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
D +D +P+H+A+ G V + + LL+ + +PN +A NG T LH+AC K + VV+
Sbjct: 354 DVTVDYL--TPLHVAAHCGHVRVAKLLLDRSADPNS--RALNGFTPLHIACKKNRIKVVE 409
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL++ A++ G PLH AA G++ IV L + + +++ G +PL A
Sbjct: 410 LLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARAN 469
Query: 186 HGDVAVTLV 194
DV L+
Sbjct: 470 QTDVVRVLI 478
Score = 75.9 bits (185), Expect = 4e-14
Identities = 54/190 (28%), Positives = 91/190 (47%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC KV ++L ++ A++ + G PLH A NI+ LL D++
Sbjct: 396 LHIACKKNRI-KVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVE 454
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+ E+ P+H+A+ ++ L+ + + +D QA T LH+A + ++V L
Sbjct: 455 TVRGET---PLHLAARANQTDVVRVLIRNGAK--VDAQARELQTPLHIASRLGNTDIVIL 509
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA+ PLH AA G + IL D N+ + K G++PL A G+
Sbjct: 510 LLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGN 569
Query: 187 GDVAVTLVNK 196
+V L+ +
Sbjct: 570 LEVVRLLLER 579
Score = 73.2 bits (178), Expect = 3e-13
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+ E V+ +L E V ++ + PLH A + D + +LL
Sbjct: 561 LHLASKYGNLEVVRLLL-ERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAA 619
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++G++P+HIA+ + I LL +PN +A G T LHL+ + H + L
Sbjct: 620 A---KNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRA--GFTPLHLSAQEGHKEISGL 674
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E G+ V K G +H A V + IL + + +N K G++PL A G
Sbjct: 675 LIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQ 734
Query: 187 GDVAVTLV 194
++ LV
Sbjct: 735 LNMVKFLV 742
Score = 68.9 bits (167), Expect = 5e-12
Identities = 73/269 (27%), Positives = 108/269 (40%), Gaps = 75/269 (27%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G + + IL E V V+ +G PL+ A + ++ LL + L
Sbjct: 103 LHIASLAGQS-LIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALS 161
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------EP 99
T E G++P+ +A G ++ LL + E
Sbjct: 162 T---EDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEH 218
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASV------------------------- 134
N D+ + +G T LH+A H NV QLL+E+GA+V
Sbjct: 219 NPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANL 278
Query: 135 ----------RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
R KD L PLH AA SG +V +L + +P++ K KNG +PL A
Sbjct: 279 LLSRGAIIDSRTKDLL--TPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQG 336
Query: 185 GHGDVAVTLVNKYHALWEGETDNDDLSID 213
H D A TL+ YH DD+++D
Sbjct: 337 DHVDAARTLL--YH-----RAPVDDVTVD 358
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/187 (28%), Positives = 78/187 (40%), Gaps = 6/187 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A E + L +F K G PLH + I +L+ +
Sbjct: 627 LHIAAKKNQME-IASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAK 685
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+G + +H+ + V + + L N+ E N + N G T LH+AC LN+V+
Sbjct: 686 A---NNGLTAMHLCAQEDHVPVAQILYNNGAEINS--KTNAGYTPLHVACHFGQLNMVKF 740
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LVE GA V K PLH+AA G V L + + N + G +PL A G+
Sbjct: 741 LVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGY 800
Query: 187 GDVAVTL 193
V TL
Sbjct: 801 VSVVETL 807
Score = 63.9 bits (154), Expect = 2e-10
Identities = 62/234 (26%), Positives = 94/234 (39%), Gaps = 40/234 (17%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A DT +L V G PLH A + +N+ +LL ++
Sbjct: 198 LHIAAKKDDTTAATLLLQNEHNP-DVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQ 256
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
SP+H+A+ G + LL+ +D + + +T LH A H VV L
Sbjct: 257 A---RHNISPLHVATKWGRTNMANLLLSRGAI--IDSRTKDLLTPLHCAARSGHDQVVDL 311
Query: 127 LVERGA--SVRIKDGLGQL-------------------------------PLHRAAASGS 153
LV +GA S + K+GL L PLH AA G
Sbjct: 312 LVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGH 371
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDN 207
V + +L D+++ N + NG++PL H + + V L+ KY A E T++
Sbjct: 372 VRVAKLLLDRSADPNSRALNGFTPL-HIACKKNRIKVVELLLKYRAAIEATTES 424
Score = 62.0 bits (149), Expect = 7e-10
Identities = 38/108 (35%), Positives = 60/108 (55%), Gaps = 3/108 (2%)
Query: 89 LEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLH 146
LEK+L + D+ +N G+ +LHLA + H VV+ L++R A V G LH
Sbjct: 46 LEKVLE-LLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALH 104
Query: 147 RAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
A+ +G IV+IL + + VN++ NG++PL+ A E H +V L+
Sbjct: 105 IASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLL 152
Score = 61.2 bits (147), Expect = 1e-09
Identities = 51/191 (26%), Positives = 86/191 (44%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAV-KVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G T +LS GA+ + D PLH A D ++D+L+ I
Sbjct: 264 LHVATKWGRTNMANLLLSR--GAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISA 321
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
T ++G +P+H+A+ V LL H +D + +T LH+A H+ V +
Sbjct: 322 KT---KNGLAPLHMAAQGDHVDAARTLLYHRAP--VDDVTVDYLTPLHVAAHCGHVRVAK 376
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL++R A + G PLH A + +V +L + + ++G +PL A G
Sbjct: 377 LLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMG 436
Query: 186 HGDVAVTLVNK 196
++ + L+ +
Sbjct: 437 AINIVIYLLQQ 447
Score = 60.1 bits (144), Expect = 3e-09
Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
A GD EKV ++L + + +G LH A ++ L+ ++D T
Sbjct: 40 AARAGDLEKVLELLRAGTD-INTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAAT-- 96
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
G + +HIAS G I+ L+ + N+++Q+ NG T L++A + H VV+ L++
Sbjct: 97 -RKGNTALHIASLAGQSLIVTILVENGA--NVNVQSVNGFTPLYMAAQENHEEVVKYLLK 153
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
GA+ + G PL A G +V++L + +S ++ P H A+
Sbjct: 154 HGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVR-----LPALHIAAKKDDTT 208
Query: 190 AVTLV 194
A TL+
Sbjct: 209 AATLL 213
>CE06703 [M] KOG4177 Ankyrin
Length = 1809
Score = 85.9 bits (211), Expect = 4e-17
Identities = 61/210 (29%), Positives = 100/210 (47%), Gaps = 8/210 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+T+ V +L + D PLH A Q+ + ILL +
Sbjct: 495 LHIASRLGNTDIVILLLQAGANS-NATTRDNYSPLHIAAKEGQEEVAGILLDHNAD---K 550
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+L + G++P+H+AS G++ ++ LL +D++ N +T LH+A + V L
Sbjct: 551 TLLTKKGFTPLHLASKYGNLEVVRLLLERGTP--VDIEGKNQVTPLHVAAHYNNDKVAML 608
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E GAS + G PLH AA + I S L + N K + G++PL + EGH
Sbjct: 609 LLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGH 668
Query: 187 GDVAVTLVNKYHALWEGETDNDDLSIDKIC 216
+++ L+ + G N+ L+ +C
Sbjct: 669 KEISGLLIENGSDV--GAKANNGLTAMHLC 696
Score = 85.1 bits (209), Expect = 7e-17
Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + + +KV +L E + K +G PLH A Q I LL + K D +
Sbjct: 594 LHVAA-HYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQF--KADPN 650
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+G++P+H+++ G I L+ + + + +ANNG+TA+HL + H+ V Q+
Sbjct: 651 A-KSRAGFTPLHLSAQEGHKEISGLLIENGSD--VGAKANNGLTAMHLCAQEDHVPVAQI 707
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L GA + K G PLH A G + +V L + + V K + ++PL A +GH
Sbjct: 708 LYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGH 767
Query: 187 GD 188
+
Sbjct: 768 NN 769
Score = 84.7 bits (208), Expect = 1e-16
Identities = 59/189 (31%), Positives = 96/189 (50%), Gaps = 6/189 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A + ++++LL Y I+
Sbjct: 363 LHVAAHCGHV-RVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEAT 421
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T ESG +P+H+A+ +G++ I+ LL P D++ G T LHLA +VV++
Sbjct: 422 T---ESGLTPLHVAAFMGAINIVIYLLQQGANP--DVETVRGETPLHLAARANQTDVVRV 476
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ GA V + Q PLH A+ G+ IV +L + N ++ +SPL A EG
Sbjct: 477 LIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQ 536
Query: 187 GDVAVTLVN 195
+VA L++
Sbjct: 537 EEVAGILLD 545
Score = 83.6 bits (205), Expect = 2e-16
Identities = 58/189 (30%), Positives = 95/189 (49%), Gaps = 8/189 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A +G + V ++ + GA + K +G PLH A + LL + +D
Sbjct: 297 LHCAARSGHDQVVDLLVVQ--GAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVD- 353
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
D +D +P+H+A+ G V + + LL+ + +PN +A NG T LH+AC K + VV+
Sbjct: 354 DVTVDYL--TPLHVAAHCGHVRVAKLLLDRSADPNS--RALNGFTPLHIACKKNRIKVVE 409
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL++ A++ G PLH AA G++ IV L + + +++ G +PL A
Sbjct: 410 LLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARAN 469
Query: 186 HGDVAVTLV 194
DV L+
Sbjct: 470 QTDVVRVLI 478
Score = 75.9 bits (185), Expect = 4e-14
Identities = 54/190 (28%), Positives = 91/190 (47%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC KV ++L ++ A++ + G PLH A NI+ LL D++
Sbjct: 396 LHIACKKNRI-KVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVE 454
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+ E+ P+H+A+ ++ L+ + + +D QA T LH+A + ++V L
Sbjct: 455 TVRGET---PLHLAARANQTDVVRVLIRNGAK--VDAQARELQTPLHIASRLGNTDIVIL 509
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA+ PLH AA G + IL D N+ + K G++PL A G+
Sbjct: 510 LLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGN 569
Query: 187 GDVAVTLVNK 196
+V L+ +
Sbjct: 570 LEVVRLLLER 579
Score = 73.2 bits (178), Expect = 3e-13
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+ E V+ +L E V ++ + PLH A + D + +LL
Sbjct: 561 LHLASKYGNLEVVRLLL-ERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAA 619
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++G++P+HIA+ + I LL +PN +A G T LHL+ + H + L
Sbjct: 620 A---KNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRA--GFTPLHLSAQEGHKEISGL 674
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E G+ V K G +H A V + IL + + +N K G++PL A G
Sbjct: 675 LIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQ 734
Query: 187 GDVAVTLV 194
++ LV
Sbjct: 735 LNMVKFLV 742
Score = 68.9 bits (167), Expect = 5e-12
Identities = 73/269 (27%), Positives = 108/269 (40%), Gaps = 75/269 (27%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G + + IL E V V+ +G PL+ A + ++ LL + L
Sbjct: 103 LHIASLAGQS-LIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALS 161
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------EP 99
T E G++P+ +A G ++ LL + E
Sbjct: 162 T---EDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEH 218
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASV------------------------- 134
N D+ + +G T LH+A H NV QLL+E+GA+V
Sbjct: 219 NPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANL 278
Query: 135 ----------RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
R KD L PLH AA SG +V +L + +P++ K KNG +PL A
Sbjct: 279 LLSRGAIIDSRTKDLL--TPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQG 336
Query: 185 GHGDVAVTLVNKYHALWEGETDNDDLSID 213
H D A TL+ YH DD+++D
Sbjct: 337 DHVDAARTLL--YH-----RAPVDDVTVD 358
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/187 (28%), Positives = 78/187 (40%), Gaps = 6/187 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A E + L +F K G PLH + I +L+ +
Sbjct: 627 LHIAAKKNQME-IASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAK 685
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+G + +H+ + V + + L N+ E N + N G T LH+AC LN+V+
Sbjct: 686 A---NNGLTAMHLCAQEDHVPVAQILYNNGAEINS--KTNAGYTPLHVACHFGQLNMVKF 740
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LVE GA V K PLH+AA G V L + + N + G +PL A G+
Sbjct: 741 LVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGY 800
Query: 187 GDVAVTL 193
V TL
Sbjct: 801 VSVVETL 807
Score = 63.9 bits (154), Expect = 2e-10
Identities = 62/234 (26%), Positives = 94/234 (39%), Gaps = 40/234 (17%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A DT +L V G PLH A + +N+ +LL ++
Sbjct: 198 LHIAAKKDDTTAATLLLQNEHNP-DVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQ 256
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
SP+H+A+ G + LL+ +D + + +T LH A H VV L
Sbjct: 257 A---RHNISPLHVATKWGRTNMANLLLSRGAI--IDSRTKDLLTPLHCAARSGHDQVVDL 311
Query: 127 LVERGA--SVRIKDGLGQL-------------------------------PLHRAAASGS 153
LV +GA S + K+GL L PLH AA G
Sbjct: 312 LVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGH 371
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDN 207
V + +L D+++ N + NG++PL H + + V L+ KY A E T++
Sbjct: 372 VRVAKLLLDRSADPNSRALNGFTPL-HIACKKNRIKVVELLLKYRAAIEATTES 424
Score = 62.0 bits (149), Expect = 7e-10
Identities = 38/108 (35%), Positives = 60/108 (55%), Gaps = 3/108 (2%)
Query: 89 LEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLH 146
LEK+L + D+ +N G+ +LHLA + H VV+ L++R A V G LH
Sbjct: 46 LEKVLE-LLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALH 104
Query: 147 RAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
A+ +G IV+IL + + VN++ NG++PL+ A E H +V L+
Sbjct: 105 IASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLL 152
Score = 61.2 bits (147), Expect = 1e-09
Identities = 51/191 (26%), Positives = 86/191 (44%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAV-KVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G T +LS GA+ + D PLH A D ++D+L+ I
Sbjct: 264 LHVATKWGRTNMANLLLSR--GAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISA 321
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
T ++G +P+H+A+ V LL H +D + +T LH+A H+ V +
Sbjct: 322 KT---KNGLAPLHMAAQGDHVDAARTLLYHRAP--VDDVTVDYLTPLHVAAHCGHVRVAK 376
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL++R A + G PLH A + +V +L + + ++G +PL A G
Sbjct: 377 LLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMG 436
Query: 186 HGDVAVTLVNK 196
++ + L+ +
Sbjct: 437 AINIVIYLLQQ 447
Score = 60.1 bits (144), Expect = 3e-09
Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
A GD EKV ++L + + +G LH A ++ L+ ++D T
Sbjct: 40 AARAGDLEKVLELLRAGTD-INTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAAT-- 96
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
G + +HIAS G I+ L+ + N+++Q+ NG T L++A + H VV+ L++
Sbjct: 97 -RKGNTALHIASLAGQSLIVTILVENGA--NVNVQSVNGFTPLYMAAQENHEEVVKYLLK 153
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
GA+ + G PL A G +V++L + +S ++ P H A+
Sbjct: 154 HGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVR-----LPALHIAAKKDDTT 208
Query: 190 AVTLV 194
A TL+
Sbjct: 209 AATLL 213
>CE06702 [M] KOG4177 Ankyrin
Length = 2039
Score = 85.9 bits (211), Expect = 4e-17
Identities = 61/210 (29%), Positives = 100/210 (47%), Gaps = 8/210 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+T+ V +L + D PLH A Q+ + ILL +
Sbjct: 495 LHIASRLGNTDIVILLLQAGANS-NATTRDNYSPLHIAAKEGQEEVAGILLDHNAD---K 550
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+L + G++P+H+AS G++ ++ LL +D++ N +T LH+A + V L
Sbjct: 551 TLLTKKGFTPLHLASKYGNLEVVRLLLERGTP--VDIEGKNQVTPLHVAAHYNNDKVAML 608
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E GAS + G PLH AA + I S L + N K + G++PL + EGH
Sbjct: 609 LLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGH 668
Query: 187 GDVAVTLVNKYHALWEGETDNDDLSIDKIC 216
+++ L+ + G N+ L+ +C
Sbjct: 669 KEISGLLIENGSDV--GAKANNGLTAMHLC 696
Score = 85.1 bits (209), Expect = 7e-17
Identities = 55/182 (30%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + + +KV +L E + K +G PLH A Q I LL + K D +
Sbjct: 594 LHVAA-HYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKNQMEIASTLLQF--KADPN 650
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+G++P+H+++ G I L+ + + + +ANNG+TA+HL + H+ V Q+
Sbjct: 651 A-KSRAGFTPLHLSAQEGHKEISGLLIENGSD--VGAKANNGLTAMHLCAQEDHVPVAQI 707
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L GA + K G PLH A G + +V L + + V K + ++PL A +GH
Sbjct: 708 LYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGH 767
Query: 187 GD 188
+
Sbjct: 768 NN 769
Score = 84.7 bits (208), Expect = 1e-16
Identities = 59/189 (31%), Positives = 96/189 (50%), Gaps = 6/189 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A + ++++LL Y I+
Sbjct: 363 LHVAAHCGHV-RVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEAT 421
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T ESG +P+H+A+ +G++ I+ LL P D++ G T LHLA +VV++
Sbjct: 422 T---ESGLTPLHVAAFMGAINIVIYLLQQGANP--DVETVRGETPLHLAARANQTDVVRV 476
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ GA V + Q PLH A+ G+ IV +L + N ++ +SPL A EG
Sbjct: 477 LIRNGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQ 536
Query: 187 GDVAVTLVN 195
+VA L++
Sbjct: 537 EEVAGILLD 545
Score = 83.6 bits (205), Expect = 2e-16
Identities = 58/189 (30%), Positives = 95/189 (49%), Gaps = 8/189 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A +G + V ++ + GA + K +G PLH A + LL + +D
Sbjct: 297 LHCAARSGHDQVVDLLVVQ--GAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVD- 353
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
D +D +P+H+A+ G V + + LL+ + +PN +A NG T LH+AC K + VV+
Sbjct: 354 DVTVDYL--TPLHVAAHCGHVRVAKLLLDRSADPNS--RALNGFTPLHIACKKNRIKVVE 409
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL++ A++ G PLH AA G++ IV L + + +++ G +PL A
Sbjct: 410 LLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARAN 469
Query: 186 HGDVAVTLV 194
DV L+
Sbjct: 470 QTDVVRVLI 478
Score = 75.9 bits (185), Expect = 4e-14
Identities = 54/190 (28%), Positives = 91/190 (47%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC KV ++L ++ A++ + G PLH A NI+ LL D++
Sbjct: 396 LHIACKKNRI-KVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVE 454
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+ E+ P+H+A+ ++ L+ + + +D QA T LH+A + ++V L
Sbjct: 455 TVRGET---PLHLAARANQTDVVRVLIRNGAK--VDAQARELQTPLHIASRLGNTDIVIL 509
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA+ PLH AA G + IL D N+ + K G++PL A G+
Sbjct: 510 LLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGN 569
Query: 187 GDVAVTLVNK 196
+V L+ +
Sbjct: 570 LEVVRLLLER 579
Score = 73.2 bits (178), Expect = 3e-13
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+ E V+ +L E V ++ + PLH A + D + +LL
Sbjct: 561 LHLASKYGNLEVVRLLL-ERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAA 619
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++G++P+HIA+ + I LL +PN +A G T LHL+ + H + L
Sbjct: 620 A---KNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRA--GFTPLHLSAQEGHKEISGL 674
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E G+ V K G +H A V + IL + + +N K G++PL A G
Sbjct: 675 LIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQ 734
Query: 187 GDVAVTLV 194
++ LV
Sbjct: 735 LNMVKFLV 742
Score = 68.9 bits (167), Expect = 5e-12
Identities = 73/269 (27%), Positives = 108/269 (40%), Gaps = 75/269 (27%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G + + IL E V V+ +G PL+ A + ++ LL + L
Sbjct: 103 LHIASLAGQS-LIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQALS 161
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------EP 99
T E G++P+ +A G ++ LL + E
Sbjct: 162 T---EDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEH 218
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASV------------------------- 134
N D+ + +G T LH+A H NV QLL+E+GA+V
Sbjct: 219 NPDVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANL 278
Query: 135 ----------RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
R KD L PLH AA SG +V +L + +P++ K KNG +PL A
Sbjct: 279 LLSRGAIIDSRTKDLL--TPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQG 336
Query: 185 GHGDVAVTLVNKYHALWEGETDNDDLSID 213
H D A TL+ YH DD+++D
Sbjct: 337 DHVDAARTLL--YH-----RAPVDDVTVD 358
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/187 (28%), Positives = 78/187 (40%), Gaps = 6/187 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A E + L +F K G PLH + I +L+ +
Sbjct: 627 LHIAAKKNQME-IASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAK 685
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+G + +H+ + V + + L N+ E N + N G T LH+AC LN+V+
Sbjct: 686 A---NNGLTAMHLCAQEDHVPVAQILYNNGAEINS--KTNAGYTPLHVACHFGQLNMVKF 740
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LVE GA V K PLH+AA G V L + + N + G +PL A G+
Sbjct: 741 LVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGY 800
Query: 187 GDVAVTL 193
V TL
Sbjct: 801 VSVVETL 807
Score = 63.9 bits (154), Expect = 2e-10
Identities = 62/234 (26%), Positives = 94/234 (39%), Gaps = 40/234 (17%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A DT +L V G PLH A + +N+ +LL ++
Sbjct: 198 LHIAAKKDDTTAATLLLQNEHNP-DVTSKSGFTPLHIAAHYGHENVGQLLLEKGANVNYQ 256
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
SP+H+A+ G + LL+ +D + + +T LH A H VV L
Sbjct: 257 A---RHNISPLHVATKWGRTNMANLLLSRGAI--IDSRTKDLLTPLHCAARSGHDQVVDL 311
Query: 127 LVERGA--SVRIKDGLGQL-------------------------------PLHRAAASGS 153
LV +GA S + K+GL L PLH AA G
Sbjct: 312 LVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYLTPLHVAAHCGH 371
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDN 207
V + +L D+++ N + NG++PL H + + V L+ KY A E T++
Sbjct: 372 VRVAKLLLDRSADPNSRALNGFTPL-HIACKKNRIKVVELLLKYRAAIEATTES 424
Score = 62.0 bits (149), Expect = 7e-10
Identities = 38/108 (35%), Positives = 60/108 (55%), Gaps = 3/108 (2%)
Query: 89 LEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLH 146
LEK+L + D+ +N G+ +LHLA + H VV+ L++R A V G LH
Sbjct: 46 LEKVLE-LLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAATRKGNTALH 104
Query: 147 RAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
A+ +G IV+IL + + VN++ NG++PL+ A E H +V L+
Sbjct: 105 IASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLL 152
Score = 61.2 bits (147), Expect = 1e-09
Identities = 51/191 (26%), Positives = 86/191 (44%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAV-KVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G T +LS GA+ + D PLH A D ++D+L+ I
Sbjct: 264 LHVATKWGRTNMANLLLSR--GAIIDSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISA 321
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
T ++G +P+H+A+ V LL H +D + +T LH+A H+ V +
Sbjct: 322 KT---KNGLAPLHMAAQGDHVDAARTLLYHRAP--VDDVTVDYLTPLHVAAHCGHVRVAK 376
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL++R A + G PLH A + +V +L + + ++G +PL A G
Sbjct: 377 LLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMG 436
Query: 186 HGDVAVTLVNK 196
++ + L+ +
Sbjct: 437 AINIVIYLLQQ 447
Score = 60.1 bits (144), Expect = 3e-09
Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
A GD EKV ++L + + +G LH A ++ L+ ++D T
Sbjct: 40 AARAGDLEKVLELLRAGTD-INTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDAAT-- 96
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
G + +HIAS G I+ L+ + N+++Q+ NG T L++A + H VV+ L++
Sbjct: 97 -RKGNTALHIASLAGQSLIVTILVENGA--NVNVQSVNGFTPLYMAAQENHEEVVKYLLK 153
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
GA+ + G PL A G +V++L + +S ++ P H A+
Sbjct: 154 HGANQALSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVR-----LPALHIAAKKDDTT 208
Query: 190 AVTLV 194
A TL+
Sbjct: 209 AATLL 213
>7295202 [M] KOG4177 Ankyrin
Length = 2443
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/183 (31%), Positives = 88/183 (47%), Gaps = 6/183 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A +G E+V +L E + K +G PLH A + + ILL + +D
Sbjct: 275 LHCAARSGH-EQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEV 333
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T+ + +H+A+ G V + + LL+ + N +A NG T LH+AC K L VV+L
Sbjct: 334 TV---DYLTALHVAAHCGHVRVAKLLLDRNADANA--RALNGFTPLHIACKKNRLKVVEL 388
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ GAS+ G PLH AA G + IV L ++ ++ G +PL A
Sbjct: 389 LLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQ 448
Query: 187 GDV 189
D+
Sbjct: 449 TDI 451
Score = 83.2 bits (204), Expect = 3e-16
Identities = 61/203 (30%), Positives = 98/203 (48%), Gaps = 21/203 (10%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID-- 64
LH A G+ + V +L + V D LH A QD + D++ KKI
Sbjct: 473 LHIASRLGNVDIVMLLL-QHGAQVDATTKDMYTALHIAAKEGQDEVKDLIA---KKITDH 528
Query: 65 LDTI----------LD---ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
+DT+ LD + G++P+H+ + G + + + LL E ++D Q NG+T
Sbjct: 529 IDTVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQK--EADVDAQGKNGVTP 586
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+AC + V LL+E+GAS G PLH AA + I + L + + N +
Sbjct: 587 LHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAES 646
Query: 172 KNGWSPLFHALAEGHGDVAVTLV 194
K G++PL + EGH +++ L+
Sbjct: 647 KAGFTPLHLSSQEGHAEISNLLI 669
Score = 80.9 bits (198), Expect = 1e-15
Identities = 63/191 (32%), Positives = 91/191 (46%), Gaps = 13/191 (6%)
Query: 9 AACMNGDTEKVQQILSEFPGAVKVKDDDGRYP-LHWAVSFQQDNIIDILLSYMKKIDLDT 67
A M +KV +L E KV R P LH A +LL D
Sbjct: 148 AVAMQQGHDKVVAVLLESDTRGKV-----RLPALHIAAKKDDVKAATLLLDNDHNPD--- 199
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
+ +SG++P+HIAS G+ I L+ + N A + I+ LH+A N+V LL
Sbjct: 200 VTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYS--AKHNISPLHVAAKWGKTNMVSLL 257
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHG 187
+E+G ++ K G PLH AA SG +V +L ++ +P++ K KNG +PL A H
Sbjct: 258 LEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHV 317
Query: 188 DVAVTLVNKYH 198
D A L+ YH
Sbjct: 318 DAARILL--YH 326
Score = 80.1 bits (196), Expect = 2e-15
Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G +V ++L + + +G PLH A + ++++LL + I
Sbjct: 341 LHVAAHCGHV-RVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISAT 399
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T ESG +P+H+A+ +G + I+ LL H P D+ G T LHLA +++++
Sbjct: 400 T---ESGLTPLHVAAFMGCMNIVIYLLQHDASP--DVPTVRGETPLHLAARANQTDIIRI 454
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ GA V + Q PLH A+ G+V IV +L + V+ K+ ++ L A EG
Sbjct: 455 LLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQ 514
Query: 187 GDVAVTLVNK 196
+V + K
Sbjct: 515 DEVKDLIAKK 524
Score = 77.8 bits (190), Expect = 1e-14
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 31/217 (14%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G E+V ++L E +V V+ +G PL+ A D ++ +LLS L
Sbjct: 81 LHIASLAGQ-EEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLA 139
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV---------------------------EP 99
T E G++P+ +A G ++ LL +
Sbjct: 140 T---EDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDH 196
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
N D+ + +G T LH+A + N+ LL+++GA V PLH AA G +VS+
Sbjct: 197 NPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSL 256
Query: 160 LCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
L +K + K ++G +PL A GH V L+ +
Sbjct: 257 LLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLER 293
Score = 72.4 bits (176), Expect = 5e-13
Identities = 40/109 (36%), Positives = 65/109 (58%), Gaps = 3/109 (2%)
Query: 89 LEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLH 146
LE++L H ++ N+D+ +N G+ ALHLA H++VV L+ RGA V G LH
Sbjct: 24 LERVLEH-LKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALH 82
Query: 147 RAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
A+ +G +V +L + N+ VN++ +NG++PL+ A E H V L++
Sbjct: 83 IASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLS 131
Score = 72.4 bits (176), Expect = 5e-13
Identities = 61/205 (29%), Positives = 94/205 (45%), Gaps = 21/205 (10%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G V +L + + V G PLH A Q +II ILL ++D
Sbjct: 407 LHVAAFMGCMNIVIYLL-QHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDAR 465
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSK-------- 118
++ P+HIAS +G+V I+ LL H + +D + TALH+A +
Sbjct: 466 AREQQT---PLHIASRLGNVDIVMLLLQHGAQ--VDATTKDMYTALHIAAKEGQDEVKDL 520
Query: 119 ------KHLNVVQ-LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
H++ V +L+E GA++ G PLH A G + + +L K + V+ +
Sbjct: 521 IAKKITDHIDTVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQG 580
Query: 172 KNGWSPLFHALAEGHGDVAVTLVNK 196
KNG +PL A + VA+ L+ K
Sbjct: 581 KNGVTPLHVACHYNNQQVALLLLEK 605
Score = 72.0 bits (175), Expect = 6e-13
Identities = 54/188 (28%), Positives = 89/188 (46%), Gaps = 6/188 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G T V +L E G ++ K DG PLH A + ++D+LL I
Sbjct: 242 LHVAAKWGKTNMVSLLL-EKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAK 300
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T ++G +P+H+A+ V LL H +D + +TALH+A H+ V +L
Sbjct: 301 T---KNGLAPLHMAAQGEHVDAARILLYHRAP--VDEVTVDYLTALHVAAHCGHVRVAKL 355
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++R A + G PLH A + +V +L + ++ ++G +PL A G
Sbjct: 356 LLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGC 415
Query: 187 GDVAVTLV 194
++ + L+
Sbjct: 416 MNIVIYLL 423
Score = 70.9 bits (172), Expect = 1e-12
Identities = 56/218 (25%), Positives = 93/218 (41%), Gaps = 35/218 (16%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC + + ++V +L E + +G PLH A Q +I LL Y + +
Sbjct: 587 LHVAC-HYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAE 645
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVE---------------------------- 98
+ ++G++P+H++S G I L+ H
Sbjct: 646 S---KAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILE 702
Query: 99 ---PNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVG 155
N+D+ G T LH+A N+V+ L++ GA+V +G PLH+ A G
Sbjct: 703 KNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCH 762
Query: 156 IVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTL 193
IV++L + + N + NG +PL A G+ V +L
Sbjct: 763 IVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSL 800
Score = 68.9 bits (167), Expect = 5e-12
Identities = 55/190 (28%), Positives = 84/190 (43%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A D K +L + V G PLH A + NI ++L+ ++
Sbjct: 176 LHIAAKKDDV-KAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYS 234
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ SP+H+A+ G ++ LL N++ + +G+T LH A H VV +
Sbjct: 235 A---KHNISPLHVAAKWGKTNMVSLLLEKG--GNIEAKTRDGLTPLHCAARSGHEQVVDM 289
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ERGA + K G PLH AA V IL +PV+ + + L A GH
Sbjct: 290 LLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGH 349
Query: 187 GDVAVTLVNK 196
VA L+++
Sbjct: 350 VRVAKLLLDR 359
Score = 65.9 bits (159), Expect = 5e-11
Identities = 42/144 (29%), Positives = 74/144 (51%), Gaps = 3/144 (2%)
Query: 51 NIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGIT 110
N+ +L ID++T + +G + +H+AS G + ++ +LL +D G T
Sbjct: 23 NLERVLEHLKNNIDINTS-NANGLNALHLASKDGHIHVVSELLRRGAI--VDSATKKGNT 79
Query: 111 ALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK 170
ALH+A VV+LL+E ASV ++ G PL+ AA +V +L + ++
Sbjct: 80 ALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLA 139
Query: 171 DKNGWSPLFHALAEGHGDVAVTLV 194
++G++PL A+ +GH V L+
Sbjct: 140 TEDGFTPLAVAMQQGHDKVVAVLL 163
Score = 57.8 bits (138), Expect = 1e-08
Identities = 51/196 (26%), Positives = 85/196 (43%), Gaps = 34/196 (17%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
+ + +G LH A +++ LL +D T + G + +HIAS G ++
Sbjct: 37 INTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSAT---KKGNTALHIASLAGQEEVV 93
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGA--SVRIKDGLGQL---- 143
+ LL H N+ Q+ NG T L++A + H VV+LL+ GA S+ +DG L
Sbjct: 94 KLLLEHNASVNV--QSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAM 151
Query: 144 -----------------------PLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFH 180
LH AA V ++L D + ++ K+G++PL
Sbjct: 152 QQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHI 211
Query: 181 ALAEGHGDVAVTLVNK 196
A G+ ++A L+ K
Sbjct: 212 ASHYGNQNIANLLIQK 227
>Hs10190676_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 280
Score = 83.6 bits (205), Expect = 2e-16
Identities = 57/180 (31%), Positives = 92/180 (50%), Gaps = 5/180 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A NGD E ++L E +V D +GR P+H A Q+NI+ ILL + +D+
Sbjct: 4 LHFAAQNGD-ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLR--RGVDV- 59
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++ + W P+H A+ G + I+ KLL +++ Q +G T LHLA + H V ++
Sbjct: 60 SLQGKDAWLPLHYAAWQGHLPIV-KLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARI 118
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ + V + L Q PLH AA +G +L + + +G++ L A GH
Sbjct: 119 LIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKKAVTSDGYTALHLAARNGH 178
Score = 61.6 bits (148), Expect = 9e-10
Identities = 48/157 (30%), Positives = 75/157 (47%), Gaps = 6/157 (3%)
Query: 41 LHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN 100
LH+A ++ +LL ++ +D G +P+H+A G I+ LL V+
Sbjct: 4 LHFAAQNGDESSTRLLLEKNASVNE---VDFEGRTPMHVACQHGQENIVRILLRRGVD-- 58
Query: 101 LDLQANNGITALHLACSKKHLNVVQLLVER-GASVRIKDGLGQLPLHRAAASGSVGIVSI 159
+ LQ + LH A + HL +V+LL ++ G SV + G+ PLH AA G + I
Sbjct: 59 VSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARI 118
Query: 160 LCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
L D S VN+ +PL A GH A L+++
Sbjct: 119 LIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHR 155
Score = 54.3 bits (129), Expect = 1e-07
Identities = 29/77 (37%), Positives = 42/77 (53%)
Query: 110 TALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNI 169
TALH A + +LL+E+ ASV D G+ P+H A G IV IL + V++
Sbjct: 2 TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSL 61
Query: 170 KDKNGWSPLFHALAEGH 186
+ K+ W PL +A +GH
Sbjct: 62 QGKDAWLPLHYAAWQGH 78
>7297920 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 585
Score = 82.0 bits (201), Expect = 6e-16
Identities = 56/185 (30%), Positives = 91/185 (48%), Gaps = 9/185 (4%)
Query: 8 HAACMNGDTEKVQQILSEF-PGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
H +NG+ + ++ ++ P + G P+HWA +++ +LL ++
Sbjct: 126 HWIALNGNVQLMRYLIERTAPIDLPCLGTQGPRPIHWACRKGHASVVQVLLQAGVAVNA- 184
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNL-DLQANNGITALHLACSKKHLNVVQ 125
D G +P+H+A G LL NL D+ NG TALH A K H ++++
Sbjct: 185 --ADFKGLTPLHLACMYGRTATAAYLLGMGALNNLTDI---NGDTALHWAAYKGHADLMR 239
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNS-PVNIKDKNGWSPLFHALAE 184
LL+ G ++ D G PLH A SG++ V +LC+K+ + +DKNG +P+ A A
Sbjct: 240 LLMYSGVELQKTDNFGSTPLHLACLSGNMTCVRLLCEKSQLDLEPRDKNGKTPIMLAQAH 299
Query: 185 GHGDV 189
H DV
Sbjct: 300 QHQDV 304
Score = 70.1 bits (170), Expect = 2e-12
Identities = 43/138 (31%), Positives = 66/138 (47%), Gaps = 2/138 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D G++P H + G+V ++ L+ T +L G +H AC K H +VVQ+L++
Sbjct: 118 DRHGYTPAHWIALNGNVQLMRYLIERTAPIDLPCLGTQGPRPIHWACRKGHASVVQVLLQ 177
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
G +V D G PLH A G + L + N+ D NG + L A +GH D+
Sbjct: 178 AGVAVNAADFKGLTPLHLACMYGRTATAAYLLGMGALNNLTDINGDTALHWAAYKGHADL 237
Query: 190 AVTLVNKYHALWEGETDN 207
L+ Y + +TDN
Sbjct: 238 MRLLM--YSGVELQKTDN 253
>Hs20538133 [R] KOG0504 FOG: Ankyrin repeat
Length = 899
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/206 (28%), Positives = 102/206 (49%), Gaps = 21/206 (10%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + K + L ++D G +H++ ++ + ++ S + LD
Sbjct: 321 LHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIAS---ETPLD 377
Query: 67 TILDESGW------------SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHL 114
+++ SG SP+H+A+ G LE L+ ++ LD++ ++G T L L
Sbjct: 378 VLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLD--LDVRNSSGRTPLDL 435
Query: 115 ACSKKHLNVVQLLVERGASVRIKDG-LGQLPLHRAAASGSVGIVSILCDKNSP---VNIK 170
A K H+ V +L+ +GAS+ +KD L + P+H AA +G + +L P V+I+
Sbjct: 436 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 495
Query: 171 DKNGWSPLFHALAEGHGDVAVTLVNK 196
D NG +PL ++ GH D +L+NK
Sbjct: 496 DGNGQTPLMLSVLNGHTDCVYSLLNK 521
Score = 79.0 bits (193), Expect = 5e-15
Identities = 58/176 (32%), Positives = 90/176 (50%), Gaps = 10/176 (5%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA--VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID 64
LH A +N D E ++L + GA V D GR PLH A + +LLS+ +++
Sbjct: 638 LHCAVIN-DNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 696
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
+D +G +P+ +A+ G +E L++ + L LQ N+ TALHLACSK H
Sbjct: 697 S---VDSTGKTPLMMAAENGQTNTVEMLVS-SASAELTLQDNSKNTALHLACSKGHETSA 752
Query: 125 QLLVERGAS---VRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSP 177
L++E+ + + Q PLH AA +G +V L K + V D+NG++P
Sbjct: 753 LLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 808
Score = 74.7 bits (182), Expect = 1e-13
Identities = 66/230 (28%), Positives = 99/230 (42%), Gaps = 42/230 (18%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
L + +NG T+ V +L++ GA V KD GR LH + +D LL + K
Sbjct: 503 LMLSVLNGHTDCVYSLLNK--GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKC-- 558
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNH--TVEPNLDLQANNGITALHLACSKKHLNV 123
+ D G +P+H++++ G + +L LL +++ N N+G TALH AC H
Sbjct: 559 -LLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETC 617
Query: 124 VQLLVER---------------------------------GAS-VRIKDGLGQLPLHRAA 149
V+LL+E+ GAS V D G+ PLH AA
Sbjct: 618 VELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAA 677
Query: 150 ASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHA 199
+ V + +L N+ VN D G +PL A G + LV+ A
Sbjct: 678 FTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASA 727
Score = 68.9 bits (167), Expect = 5e-12
Identities = 52/182 (28%), Positives = 87/182 (47%), Gaps = 6/182 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL- 65
LH A +G + ++ ++ + V++ GR PL A +D+L++ I +
Sbjct: 400 LHLAAYHGHHQALEVLVQSLLD-LDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVK 458
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN-LDLQANNGITALHLACSKKHLNVV 124
D IL + P+H A++ G L L+ + N +D+Q NG T L L+ H + V
Sbjct: 459 DYILKRT---PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCV 515
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
L+ +GA+V KD G+ LHR A +G V L + ++D G +P+ + A
Sbjct: 516 YSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAAC 575
Query: 185 GH 186
GH
Sbjct: 576 GH 577
Score = 66.6 bits (161), Expect = 3e-11
Identities = 52/193 (26%), Positives = 86/193 (43%), Gaps = 35/193 (18%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL 93
D R +HWA ++ +L+S+ ++ T D+ ++P+H A+S G +++++ LL
Sbjct: 16 DKKDRRAIHWAAYMGHIEVVKLLVSHGAEV---TCKDKKSYTPLHAAASSGMISVVKYLL 72
Query: 94 NHTV---EPNL--------------DLQANN--------------GITALHLACSKKHLN 122
+ V EPN D+ N G T LH A + H
Sbjct: 73 DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGA 132
Query: 123 V-VQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
+ ++LLV GA V +K G+ PLH A G + + ++ +DKNG +PL A
Sbjct: 133 LCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIA 192
Query: 182 LAEGHGDVAVTLV 194
GH + TL+
Sbjct: 193 ARYGHELLINTLI 205
Score = 66.6 bits (161), Expect = 3e-11
Identities = 53/176 (30%), Positives = 84/176 (47%), Gaps = 8/176 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAV-KVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH ++G + Q I+ GAV +D +G PLH A + + +I+ L++
Sbjct: 156 LHMTALHGRFSRSQTIIQS--GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAK 213
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
I G P+H+A+ G KLL+ + +D + G T LH A + +L +
Sbjct: 214 RGI---HGMFPLHLAALSGFSDCCRKLLSSGFD--IDTPDDFGRTCLHAAAAGGNLECLN 268
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
LL+ GA KD G+ PLH AAA+ + + L + VN D+ G +PL +A
Sbjct: 269 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 324
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/154 (28%), Positives = 76/154 (48%), Gaps = 5/154 (3%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
V +K DG+ PLH + + ++ ID + D++G +P+HIA+ G ++
Sbjct: 145 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE---DKNGNTPLHIAARYGHELLI 201
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAA 149
L+ T + + +G+ LHLA + + L+ G + D G+ LH AA
Sbjct: 202 NTLI--TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAA 259
Query: 150 ASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
A G++ +++L + + N KDK G SPL +A A
Sbjct: 260 AGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAA 293
Score = 62.4 bits (150), Expect = 5e-10
Identities = 40/143 (27%), Positives = 74/143 (50%), Gaps = 5/143 (3%)
Query: 52 IIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
++ +LLS I+ D+ +H A+ +G + +++ L++H E + + T
Sbjct: 1 MVKLLLSRGANINA---FDKKDRRAIHWAAYMGHIEVVKLLVSHGAE--VTCKDKKSYTP 55
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH A S ++VV+ L++ G + + G PLH A +G +V+ L D + VN K+
Sbjct: 56 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 115
Query: 172 KNGWSPLFHALAEGHGDVAVTLV 194
+ G++PL A A HG + + L+
Sbjct: 116 EKGFTPLHFAAASTHGALCLELL 138
Score = 62.4 bits (150), Expect = 5e-10
Identities = 48/185 (25%), Positives = 85/185 (45%), Gaps = 8/185 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDD-GRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
L A G E V ++++ ++ VKD R P+H A + + +L+ + +
Sbjct: 433 LDLAAFKGHVECVDVLINQ-GASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 491
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
I D +G +P+ ++ G + LLN N+D + G TALH H V
Sbjct: 492 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA--NVDAKDKWGRTALHRGAVTGHEECVD 549
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK----DKNGWSPLFHA 181
L++ GA ++D G+ P+H +AA G +G++ L + ++ D +G++ L A
Sbjct: 550 ALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWA 609
Query: 182 LAEGH 186
GH
Sbjct: 610 CYNGH 614
Score = 59.7 bits (143), Expect = 3e-09
Identities = 52/188 (27%), Positives = 87/188 (45%), Gaps = 16/188 (8%)
Query: 16 TEKVQQILSEFPGAVKVKDDDGRY---PLHWAVSFQQDNIIDILLSYMKKIDLDTILDES 72
+E +L E G + D D R PLH A +++L+ + +DLD + + S
Sbjct: 372 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSL--LDLD-VRNSS 428
Query: 73 GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI---TALHLACSKKHLNVVQLLV- 128
G +P+ +A+ G V ++ L+N + + I T +H A + H ++LL+
Sbjct: 429 GRTPLDLAAFKGHVECVDVLINQ----GASILVKDYILKRTPIHAAATNGHSECLRLLIG 484
Query: 129 --ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
E +V I+DG GQ PL + +G V L +K + V+ KDK G + L GH
Sbjct: 485 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH 544
Query: 187 GDVAVTLV 194
+ L+
Sbjct: 545 EECVDALL 552
Score = 58.2 bits (139), Expect = 1e-08
Identities = 47/190 (24%), Positives = 86/190 (44%), Gaps = 7/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNI-IDILLSYMKKIDL 65
LH AC NG V +++ + V K++ G PLH+A + + +++L+ +++
Sbjct: 89 LHVACYNGQDVVVNELI-DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM 147
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
+ + G +P+H+ + G + + ++ +D + NG T LH+A H ++
Sbjct: 148 KS---KDGKTPLHMTALHGRFSRSQTIIQSGAV--IDCEDKNGNTPLHIAARYGHELLIN 202
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
L+ GA + G PLH AA SG L ++ D G + L A A G
Sbjct: 203 TLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGG 262
Query: 186 HGDVAVTLVN 195
+ + L+N
Sbjct: 263 NLECLNLLLN 272
Score = 57.4 bits (137), Expect = 2e-08
Identities = 41/164 (25%), Positives = 76/164 (46%), Gaps = 5/164 (3%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL 93
D+ G LHWA + +++LL ++ + + +SP+H A + E L+
Sbjct: 599 DNHGYTALHWACYNGHETCVELLLEQ----EVFQKTEGNAFSPLHCAVINDNEGAAEMLI 654
Query: 94 NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGS 153
+ ++ + G T LH A H+ +QLL+ A V D G+ PL AA +G
Sbjct: 655 DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQ 714
Query: 154 VGIVSILCDK-NSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
V +L ++ + ++D + + L A ++GH A+ ++ K
Sbjct: 715 TNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 758
Score = 55.8 bits (133), Expect = 5e-08
Identities = 53/181 (29%), Positives = 84/181 (46%), Gaps = 7/181 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G + +++ K + G +PLH A + LLS D+D
Sbjct: 189 LHIAARYGHELLINTLITSGADTAK-RGIHGMFPLHLAALSGFSDCCRKLLS--SGFDID 245
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T D+ G + +H A++ G++ L LLN + N + G + LH A + + +
Sbjct: 246 TP-DDFGRTCLHAAAAGGNLECLNLLLNTGADFNK--KDKFGRSPLHYAAANCNYQCLFA 302
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVG-IVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LV GASV D G PLH AA S + G + L ++ I+DK G++ + ++ A G
Sbjct: 303 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYG 362
Query: 186 H 186
H
Sbjct: 363 H 363
Score = 54.7 bits (130), Expect = 1e-07
Identities = 32/85 (37%), Positives = 43/85 (49%)
Query: 111 ALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK 170
A+H A H+ VV+LLV GA V KD PLH AA+SG + +V L D +N
Sbjct: 22 AIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEP 81
Query: 171 DKNGWSPLFHALAEGHGDVAVTLVN 195
+ G +PL A G V L++
Sbjct: 82 NAYGNTPLHVACYNGQDVVVNELID 106
>CE26238_1 [M] KOG4177 Ankyrin
Length = 1294
Score = 79.3 bits (194), Expect = 4e-15
Identities = 52/192 (27%), Positives = 97/192 (50%), Gaps = 6/192 (3%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI 63
D LLH A +G+ E V+ ++ V++ GR PLH N++ I+ K+
Sbjct: 446 DTLLHLAARSGNIEAVRTAIAAGCDNANVQNRVGRTPLHEVAEVGDQNMLKIMF----KL 501
Query: 64 DLDT-ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
D I D+ +PVH+A+ G +++E L++ ++ + +G T LH+A H +
Sbjct: 502 RADANIHDKEDKTPVHVAAERGDTSMVESLIDK-FGGSIRARTRDGSTLLHIAACSGHTS 560
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
++RG + + + G L LH AAA+G +V +L + + V+++ ++ ++ L A+
Sbjct: 561 TALAFLKRGVPLFMPNKKGALGLHSAAAAGFNDVVKMLIARGTNVDVRTRDNYTALHVAV 620
Query: 183 AEGHGDVAVTLV 194
G V TL+
Sbjct: 621 QSGKASVVETLL 632
Score = 76.3 bits (186), Expect = 3e-14
Identities = 43/126 (34%), Positives = 70/126 (55%), Gaps = 2/126 (1%)
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
E G++P+H+A+ G +++ LLN V+ + N + LHLA + H+ VV +L+ R
Sbjct: 1156 EYGFTPLHLAAQSGHDSLVRMLLNQGVQVDATSTTMN-VIPLHLAAQQGHIAVVGMLLSR 1214
Query: 131 GASVR-IKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
+ KD G+ PLH AA +G +VS+L + S +N+ D+NGW+ L A GH V
Sbjct: 1215 STQQQHAKDWRGRTPLHLAAQNGHYEMVSLLIAQGSNINVMDQNGWTGLHFATRAGHLSV 1274
Query: 190 AVTLVN 195
++
Sbjct: 1275 VKLFID 1280
Score = 72.0 bits (175), Expect = 6e-13
Identities = 50/189 (26%), Positives = 93/189 (48%), Gaps = 15/189 (7%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNI---------IDILLSYMKKIDLDTILDESGWSPVHIA 80
V + +DG LH+A +Q + +++L+ Y +++ ++ + + +H+A
Sbjct: 751 VNHRTNDGFTALHYAAEIEQRQLHFPGEDAKLVNLLIDYGGMVEMPSL--NANETAMHMA 808
Query: 81 SSIGSVTILEKLLNH----TVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRI 136
+ G+ +L ++N V+ + Q+ NG + L AC++ H V +L++ A + +
Sbjct: 809 ARSGNQAVLLAMVNKIGAGAVQIVQNKQSKNGWSPLLEACARGHSGVANILLKHHARIDV 868
Query: 137 KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
D +G+ LH AA +G + +V +L + VN K K G +PL A GH V LV
Sbjct: 869 FDEMGRTALHLAAFNGHLSLVHLLLQHKAFVNSKSKTGEAPLHLAAQHGHVKVVNVLVQD 928
Query: 197 YHALWEGET 205
+ A E T
Sbjct: 929 HGAALEAIT 937
Score = 68.9 bits (167), Expect = 5e-12
Identities = 47/192 (24%), Positives = 84/192 (43%), Gaps = 2/192 (1%)
Query: 8 HAACMNGDTEKVQQILSEFPGAV-KVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
H A M E ++ IL + + K + +H A + I+ ++ D
Sbjct: 344 HIAAMYSGVETLELILKRYSELLRKGAGPKKQLAIHVACERKSKKAFPIVKRILEDTDQR 403
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D G P+H+A G+V I+E LL+ + NG T LHLA ++ V+
Sbjct: 404 MAEDGDGSLPIHLAFKFGNVNIVELLLSGPSDEQTRKADGNGDTLLHLAARSGNIEAVRT 463
Query: 127 LVERGA-SVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+ G + +++ +G+ PLH A G ++ I+ + NI DK +P+ A G
Sbjct: 464 AIAAGCDNANVQNRVGRTPLHEVAEVGDQNMLKIMFKLRADANIHDKEDKTPVHVAAERG 523
Query: 186 HGDVAVTLVNKY 197
+ +L++K+
Sbjct: 524 DTSMVESLIDKF 535
Score = 65.9 bits (159), Expect = 5e-11
Identities = 53/202 (26%), Positives = 90/202 (44%), Gaps = 8/202 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI-DL 65
LH A G V Q L +DD G+ PLH A +++ + L +
Sbjct: 944 LHFAAKFGQLA-VSQTLLALGANPNARDDKGQTPLHLAAENDFPDVVKLFLKMRNNNRSV 1002
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI---TALHLACSKKHLN 122
T +D +G++ HIA+ GS+ ++ +L+ ++ + +QA T LH+A + H N
Sbjct: 1003 LTAIDHNGFTCAHIAAMKGSLAVVRELM--MIDKPMVIQAKTKTLEATTLHMAAAGGHAN 1060
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
+V++L+E GA+ ++ G LH A +G + I+ DK K G + L A
Sbjct: 1061 IVKILLENGANAEDENSHGMTALHLGAKNGFISILEAF-DKILWKRCSRKTGLNALHIAA 1119
Query: 183 AEGHGDVAVTLVNKYHALWEGE 204
G+ D ++ A E
Sbjct: 1120 FYGNSDFVNEMLKHVQATVRSE 1141
Score = 63.9 bits (154), Expect = 2e-10
Identities = 43/181 (23%), Positives = 83/181 (45%), Gaps = 16/181 (8%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKD-------------DDGRYPLHWAVSFQQDNII 53
LH A G+++ V ++L V+ + + G PLH A D+++
Sbjct: 1115 LHIAAFYGNSDFVNEMLKHVQATVRSEPPIYNHHVNKEFSTEYGFTPLHLAAQSGHDSLV 1174
Query: 54 DILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALH 113
+LL+ + + +D P+H+A+ G + ++ LL+ + + + G T LH
Sbjct: 1175 RMLLN--QGVQVDATSTTMNVIPLHLAAQQGHIAVVGMLLSRSTQQQ-HAKDWRGRTPLH 1231
Query: 114 LACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKN 173
LA H +V LL+ +G+++ + D G LH A +G + +V + D ++ + K
Sbjct: 1232 LAAQNGHYEMVSLLIAQGSNINVMDQNGWTGLHFATRAGHLSVVKLFIDSSADPLAETKE 1291
Query: 174 G 174
G
Sbjct: 1292 G 1292
Score = 62.4 bits (150), Expect = 5e-10
Identities = 52/189 (27%), Positives = 90/189 (47%), Gaps = 11/189 (5%)
Query: 7 LHAACMNGDTEKVQQILSEF-PGAVKV----KDDDGRYPLHWAVSFQQDNIIDILLSYMK 61
+H A +G+ + ++++ GAV++ + +G PL A + + +ILL +
Sbjct: 805 MHMAARSGNQAVLLAMVNKIGAGAVQIVQNKQSKNGWSPLLEACARGHSGVANILLKHHA 864
Query: 62 KIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHL 121
+ID + DE G + +H+A+ G ++++ LL H N ++ G LHLA H+
Sbjct: 865 RID---VFDEMGRTALHLAAFNGHLSLVHLLLQHKAFVNS--KSKTGEAPLHLAAQHGHV 919
Query: 122 NVVQLLVE-RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFH 180
VV +LV+ GA++ Q LH AA G + + L + N +D G +PL
Sbjct: 920 KVVNVLVQDHGAALEAITLDNQTALHFAAKFGQLAVSQTLLALGANPNARDDKGQTPLHL 979
Query: 181 ALAEGHGDV 189
A DV
Sbjct: 980 AAENDFPDV 988
Score = 62.0 bits (149), Expect = 7e-10
Identities = 52/209 (24%), Positives = 92/209 (43%), Gaps = 42/209 (20%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
+H A GDT V+ ++ +F G+++ + DG LH A + L+++K+
Sbjct: 516 VHVAAERGDTSMVESLIDKFGGSIRARTRDGSTLLHIAACSGHTSTA---LAFLKRGVPL 572
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ ++ G +H A++ G +++ L+ N+D++ + TALH+A +VV+
Sbjct: 573 FMPNKKGALGLHSAAAAGFNDVVKMLIARGT--NVDVRTRDNYTALHVAVQSGKASVVET 630
Query: 127 LVERGASVRIKDG-LGQLPLH------------------------------------RAA 149
L+ GA + +K G LGQ LH AA
Sbjct: 631 LLGSGADIHVKGGELGQTALHIAASLNGAESRDCAMMLLKSGGQPDVAQMDGETCLHIAA 690
Query: 150 ASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
SG+ I+ +L D+N+ I K G +PL
Sbjct: 691 RSGNKDIMRLLLDENADSKISSKIGETPL 719
Score = 62.0 bits (149), Expect = 7e-10
Identities = 61/224 (27%), Positives = 98/224 (43%), Gaps = 29/224 (12%)
Query: 1 MGADFLLHAACMNG-DTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSY 59
+G L AA +NG ++ +L + G V DG LH A +I+ +LL
Sbjct: 645 LGQTALHIAASLNGAESRDCAMMLLKSGGQPDVAQMDGETCLHIAARSGNKDIMRLLLD- 703
Query: 60 MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVE--------PNLDLQANNGITA 111
+ D I + G +P+ +A+ + +L H E +++ + N+G TA
Sbjct: 704 -ENAD-SKISSKIGETPLQVAAKSCNFEAASMILKHLSEVLTQEQLKEHVNHRTNDGFTA 761
Query: 112 LHLACS---------KKHLNVVQLLVERGASVRIKD-GLGQLPLHRAAASGSVGIVSILC 161
LH A + +V LL++ G V + + +H AA SG+ ++ +
Sbjct: 762 LHYAAEIEQRQLHFPGEDAKLVNLLIDYGGMVEMPSLNANETAMHMAARSGNQAVLLAMV 821
Query: 162 DK------NSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHA 199
+K N + KNGWSPL A A GH VA L+ K+HA
Sbjct: 822 NKIGAGAVQIVQNKQSKNGWSPLLEACARGHSGVANILL-KHHA 864
Score = 55.8 bits (133), Expect = 5e-08
Identities = 50/181 (27%), Positives = 85/181 (46%), Gaps = 11/181 (6%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
AC G + V IL + + V D+ GR LH A +++ +LL + ++ +
Sbjct: 847 ACARGHSG-VANILLKHHARIDVFDEMGRTALHLAAFNGHLSLVHLLLQHKAFVNSKS-- 903
Query: 70 DESGWSPVHIASSIGSVTILEKLL-NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV 128
++G +P+H+A+ G V ++ L+ +H L+ + TALH A L V Q L+
Sbjct: 904 -KTGEAPLHLAAQHGHVKVVNVLVQDHGAA--LEAITLDNQTALHFAAKFGQLAVSQTLL 960
Query: 129 ERGASVRIKDGLGQLPLHRAAASGSVGIVSILC----DKNSPVNIKDKNGWSPLFHALAE 184
GA+ +D GQ PLH AA + +V + + S + D NG++ A +
Sbjct: 961 ALGANPNARDDKGQTPLHLAAENDFPDVVKLFLKMRNNNRSVLTAIDHNGFTCAHIAAMK 1020
Query: 185 G 185
G
Sbjct: 1021 G 1021
Score = 50.4 bits (119), Expect = 2e-06
Identities = 43/164 (26%), Positives = 78/164 (47%), Gaps = 8/164 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH+A G + V+ +++ V V+ D LH AV + ++++ LL D+
Sbjct: 583 LHSAAAAGFNDVVKMLIARGTN-VDVRTRDNYTALHVAVQSGKASVVETLLG--SGADIH 639
Query: 67 TILDESGWSPVHIASSIGSVTILE---KLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
E G + +HIA+S+ + LL +P D+ +G T LH+A + ++
Sbjct: 640 VKGGELGQTALHIAASLNGAESRDCAMMLLKSGGQP--DVAQMDGETCLHIAARSGNKDI 697
Query: 124 VQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV 167
++LL++ A +I +G+ PL AA S + S++ S V
Sbjct: 698 MRLLLDENADSKISSKIGETPLQVAAKSCNFEAASMILKHLSEV 741
>Hs22064845 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 722
Score = 79.0 bits (193), Expect = 5e-15
Identities = 56/179 (31%), Positives = 87/179 (48%), Gaps = 6/179 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH G E+V+ +L+ V + G PL A QQ ++ +LL++ +
Sbjct: 342 LHFLVAQGSVEQVRLLLAHEVD-VDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR- 399
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+DE GW+P+H A+ G LL+H +D Q G T LHLA NV +L
Sbjct: 400 --VDEDGWAPLHFAAQNGDDGTARLLLDHGA--CVDAQEREGWTPLHLAAQNNFENVARL 455
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LV R A + + G+ PLH AA G V +V +L + + ++ + +N +PL A+ G
Sbjct: 456 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 514
Score = 74.3 bits (181), Expect = 1e-13
Identities = 45/152 (29%), Positives = 74/152 (48%), Gaps = 5/152 (3%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL 93
D+DG PLH+A D +LL + +D + GW+P+H+A+ + L+
Sbjct: 401 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ---EREGWTPLHLAAQNNFENVARLLV 457
Query: 94 NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGS 153
+ +PNL G T LH+A H+++V+LL +GA + + + PLH A G
Sbjct: 458 SRQADPNL--HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 515
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
V + L + + D++G+ PL A A G
Sbjct: 516 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 547
Score = 67.0 bits (162), Expect = 2e-11
Identities = 56/188 (29%), Positives = 88/188 (46%), Gaps = 16/188 (8%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVK-VKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI-D 64
LH A G +Q +L GAV D G PLH A + + I +LLS +
Sbjct: 507 LHLAVERGKVRAIQHLLKS--GAVPDALDQSGYGPLHTAAARGKYLICKMLLSLQGPPGE 564
Query: 65 LDTILDES----------GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHL 114
+ +L ES W+P+H+A+ G ++ LL +PN Q+ G T LHL
Sbjct: 565 IIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQS--GWTPLHL 622
Query: 115 ACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
A + V L+E A+V ++ +G P H AA G+ I+ +L + + ++++D
Sbjct: 623 AVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVS 682
Query: 175 WSPLFHAL 182
+PL AL
Sbjct: 683 CTPLQLAL 690
Score = 65.1 bits (157), Expect = 8e-11
Identities = 42/133 (31%), Positives = 68/133 (50%), Gaps = 2/133 (1%)
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
D + + E+ +P+H + GSV + LL H V+ +D Q +G T L +A + ++
Sbjct: 329 DEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVD--VDCQTASGYTPLLIAAQDQQPDL 386
Query: 124 VQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
LL+ GA D G PLH AA +G G +L D + V+ +++ GW+PL A
Sbjct: 387 CALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQ 446
Query: 184 EGHGDVAVTLVNK 196
+VA LV++
Sbjct: 447 NNFENVARLLVSR 459
Score = 60.5 bits (145), Expect = 2e-09
Identities = 59/201 (29%), Positives = 89/201 (43%), Gaps = 18/201 (8%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G V+ + S+ GA + + + R PLH AV + I LL K +
Sbjct: 474 LHVAAYFGHVSLVKLLTSQ--GAELDAQQRNLRTPLHLAVERGKVRAIQHLL---KSGAV 528
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN------LDLQANNGI------TALH 113
LD+SG+ P+H A++ G I + LL+ P + AN G T LH
Sbjct: 529 PDALDQSGYGPLHTAAARGKYLICKMLLSLQGPPGEIIHLLAESHANMGALGAVNWTPLH 588
Query: 114 LACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKN 173
LA VV L++ GA + G PLH A + V L + ++ V+ ++K
Sbjct: 589 LAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKV 648
Query: 174 GWSPLFHALAEGHGDVAVTLV 194
GW+P A +G+ + LV
Sbjct: 649 GWTPAHLAALKGNTAILKVLV 669
Score = 59.3 bits (142), Expect = 4e-09
Identities = 39/128 (30%), Positives = 62/128 (47%), Gaps = 5/128 (3%)
Query: 40 PLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEP 99
PLH A ++ ++ LL ++SGW+P+H+A + + LL H
Sbjct: 586 PLHLAARHGEEAVVSALLQCGAD---PNAAEQSGWTPLHLAVQRSTFLSVINLLEH--HA 640
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
N+ + G T HLA K + ++++LVE GA + ++DG+ PL A S GI+S
Sbjct: 641 NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSF 700
Query: 160 LCDKNSPV 167
L K V
Sbjct: 701 LEGKEPSV 708
Score = 55.5 bits (132), Expect = 6e-08
Identities = 41/157 (26%), Positives = 71/157 (45%), Gaps = 5/157 (3%)
Query: 40 PLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEP 99
PLH+ V+ + +LL++ +D T SG++P+ IA+ + LL H +
Sbjct: 341 PLHFLVAQGSVEQVRLLLAHEVDVDCQTA---SGYTPLLIAAQDQQPDLCALLLAHGADA 397
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
N +G LH A +LL++ GA V ++ G PLH AA + + +
Sbjct: 398 NR--VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 455
Query: 160 LCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
L + + N+ + G +PL A GH + L ++
Sbjct: 456 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ 492
>CE19848_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 185
Score = 78.6 bits (192), Expect = 7e-15
Identities = 51/137 (37%), Positives = 78/137 (56%), Gaps = 7/137 (5%)
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNG--ITALHLACSKKHL 121
DL+ ++ GW+P+ IASS G V ++ LL P++D++ N T+LH ACSK H+
Sbjct: 20 DLNCLILPLGWTPLMIASSAGRVDVVRYLL---TLPDVDVKHTNSNKQTSLHYACSKNHV 76
Query: 122 NVVQLLVERGAS-VRIKDGLGQLPLHRAAASGSVGIVSILCDKNS-PVNIKDKNGWSPLF 179
+V+LL+E + + + D G LHRAA+ G+ IV L ++ +D G + L
Sbjct: 77 EIVKLLIEADPNIINLPDKFGATALHRAASRGNDVIVRALVSTGKCSLDRQDGEGNTALH 136
Query: 180 HALAEGHGDVAVTLVNK 196
A E GDVA+ LVN+
Sbjct: 137 LACDENRGDVAILLVNR 153
Score = 53.9 bits (128), Expect = 2e-07
Identities = 44/139 (31%), Positives = 72/139 (51%), Gaps = 3/139 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L A G + V+ +L+ VK + + + LH+A S I+ +L+ I
Sbjct: 33 LMIASSAGRVDVVRYLLTLPDVDVKHTNSNKQTSLHYACSKNHVEIVKLLIEADPNII-- 90
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ D+ G + +H A+S G+ I+ L++ T + +LD Q G TALHLAC + +V L
Sbjct: 91 NLPDKFGATALHRAASRGNDVIVRALVS-TGKCSLDRQDGEGNTALHLACDENRGDVAIL 149
Query: 127 LVERGASVRIKDGLGQLPL 145
LV RGA +++ + Q PL
Sbjct: 150 LVNRGADMKMLNKEKQTPL 168
>7294199_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 708
Score = 78.2 bits (191), Expect = 9e-15
Identities = 55/178 (30%), Positives = 94/178 (51%), Gaps = 6/178 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G V+ +L+ ++D +G PLH A+S + D ++ +LL + I L+
Sbjct: 135 LHIAVNKGHLNVVKTLLT-LGCHPSLQDSEGDTPLHDAISKEHDEMLSLLLDFGADITLN 193
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNL-DLQANNGITALHLACSKKHLNVVQ 125
+ +G++ +H A+ G+ + ++ LL T P + + + ++G TALHLA H+ + +
Sbjct: 194 ---NNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDDGYTALHLAALNNHVEIAE 250
Query: 126 LLVERGASVRIKDGLG-QLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
LLV G + + + Q LH A V IV +L + +NI DK+G +PL AL
Sbjct: 251 LLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPDKDGDTPLHEAL 308
Score = 72.4 bits (176), Expect = 5e-13
Identities = 51/180 (28%), Positives = 87/180 (48%), Gaps = 13/180 (7%)
Query: 36 DGRYPLHWAVSFQQDN----IIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEK 91
+G + H A+ N +I +LL + ++++ D+ G VH A+ ++E
Sbjct: 60 NGVFAGHTALQAASQNGHIEVIQVLLRHAVDVEIE---DKDGDRAVHHAAFGDEAAVIEI 116
Query: 92 LLNHTVEPNLDLQANNGI--TALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAA 149
L + DL A N T+LH+A +K HLNVV+ L+ G ++D G PLH A
Sbjct: 117 L----AKAGADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAI 172
Query: 150 ASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDD 209
+ ++S+L D + + + + NG++ L HA +G+ L+ K + W E DD
Sbjct: 173 SKEHDEMLSLLLDFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDD 232
Score = 72.0 bits (175), Expect = 6e-13
Identities = 59/192 (30%), Positives = 99/192 (50%), Gaps = 9/192 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L AA NG E +Q +L V+++D DG +H A + +I+IL DL+
Sbjct: 69 LQAASQNGHIEVIQVLLRHAVD-VEIEDKDGDRAVHHAAFGDEAAVIEILAK--AGADLN 125
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++ + +HIA + G + +++ LL P+ LQ + G T LH A SK+H ++ L
Sbjct: 126 A-RNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPS--LQDSEGDTPLHDAISKEHDEMLSL 182
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDK-NSPVNIKDK--NGWSPLFHALA 183
L++ GA + + + G LH AA G+ + IL K N P +++K +G++ L A
Sbjct: 183 LLDFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDDGYTALHLAAL 242
Query: 184 EGHGDVAVTLVN 195
H ++A LV+
Sbjct: 243 NNHVEIAELLVH 254
Score = 67.4 bits (163), Expect = 2e-11
Identities = 46/145 (31%), Positives = 79/145 (53%), Gaps = 2/145 (1%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI 63
D LH A ++ + +++ +L +F + + +++G LH A + + ILL+ +
Sbjct: 165 DTPLHDA-ISKEHDEMLSLLLDFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRP 223
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
+ + G++ +H+A+ V I E LL H + N+D Q N TALHLA ++H+ +
Sbjct: 224 WIVEEKKDDGYTALHLAALNNHVEIAE-LLVHMGKANMDRQNVNLQTALHLAVERQHVQI 282
Query: 124 VQLLVERGASVRIKDGLGQLPLHRA 148
V+LLV+ GA + I D G PLH A
Sbjct: 283 VKLLVQDGADLNIPDKDGDTPLHEA 307
>Hs18079216 [T] KOG0507 CASK-interacting adaptor protein (caskin) and related
proteins with ankyrin repeats and SAM domain
Length = 1431
Score = 77.8 bits (190), Expect = 1e-14
Identities = 54/176 (30%), Positives = 87/176 (48%), Gaps = 14/176 (7%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A +NG+TE + +L E AV +KD+ G PLH+A + + ++L +++
Sbjct: 53 LHHAALNGNTELISLLL-EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIP 111
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ + G P+H+A+ G + E LL H + N + N+G T L LAC + VVQL
Sbjct: 112 S---DEGHIPLHLAAQHGHYDVSEMLLQH--QSNPCMVDNSGKTPLDLACEFGRVGVVQL 166
Query: 127 LVERGASVRI--------KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
L+ + D G PLH AA +G + I+ +L +N + K+G
Sbjct: 167 LLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG 222
Score = 70.9 bits (172), Expect = 1e-12
Identities = 51/176 (28%), Positives = 86/176 (47%), Gaps = 13/176 (7%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G E ++ +L AV + D+G PLH A ++ ++LL +
Sbjct: 86 LHYAAWQGRKEPMKLVLKA-GSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSN---P 141
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTV-----EPNL-DLQANNGITALHLACSKKH 120
++D SG +P+ +A G V +++ LL+ + EP D NG + LHLA H
Sbjct: 142 CMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGH 201
Query: 121 LNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWS 176
+++++LL++ G + + G LH AA G +V +L D S +N +N +S
Sbjct: 202 IDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLD--SGINAHVRNTYS 254
Score = 66.6 bits (161), Expect = 3e-11
Identities = 50/168 (29%), Positives = 75/168 (43%), Gaps = 13/168 (7%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
V +D DG LH A +I +LL +D I D G P+H A+ G +
Sbjct: 42 VNFQDPDGFSALHHAALNGNTELISLLLEAQAAVD---IKDNKGMRPLHYAAWQGRKEPM 98
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAA 149
+ +L N+ ++ G LHLA H +V ++L++ ++ + D G+ PL A
Sbjct: 99 KLVLKAGSAVNIP--SDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLAC 156
Query: 150 ASGSVGIVSILCDKNS--------PVNIKDKNGWSPLFHALAEGHGDV 189
G VG+V +L N P + D NG SPL A GH D+
Sbjct: 157 EFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDI 204
Score = 63.5 bits (153), Expect = 2e-10
Identities = 39/104 (37%), Positives = 54/104 (51%)
Query: 91 KLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAA 150
KLL T + N++ Q +G +ALH A + ++ LL+E A+V IKD G PLH AA
Sbjct: 32 KLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAW 91
Query: 151 SGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
G + ++ S VNI G PL A GH DV+ L+
Sbjct: 92 QGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLL 135
Score = 56.2 bits (134), Expect = 4e-08
Identities = 40/140 (28%), Positives = 70/140 (49%), Gaps = 3/140 (2%)
Query: 56 LLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLA 115
LL KKI+++ D G+S +H A+ G+ ++ LL + +D++ N G+ LH A
Sbjct: 33 LLGSTKKINVN-FQDPDGFSALHHAALNGNTELISLLLE--AQAAVDIKDNKGMRPLHYA 89
Query: 116 CSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGW 175
+ ++L+++ G++V I G +PLH AA G + +L S + D +G
Sbjct: 90 AWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGK 149
Query: 176 SPLFHALAEGHGDVAVTLVN 195
+PL A G V L++
Sbjct: 150 TPLDLACEFGRVGVVQLLLS 169
>Hs16076877 [R] KOG0504 FOG: Ankyrin repeat
Length = 1101
Score = 77.4 bits (189), Expect = 2e-14
Identities = 62/190 (32%), Positives = 95/190 (49%), Gaps = 6/190 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L AA G E V ++L E AV + G PL V I+D+LL++ +++
Sbjct: 139 LTAAAGRGKLE-VCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM- 196
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D+ G +P+ +A+S G + ++ LL ++ L G+TAL AC K HL+VV+
Sbjct: 197 --ADKQGRTPLMMAASEGHLGTVDFLLAQGA--SIALMDKEGLTALSWACLKGHLSVVRS 252
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LV+ GA+ D G+ PL AA G +V L D + + D +G PL A+ +
Sbjct: 253 LVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCPN 312
Query: 187 GDVAVTLVNK 196
V VTL+ K
Sbjct: 313 TSVVVTLLKK 322
Score = 57.0 bits (136), Expect = 2e-08
Identities = 49/169 (28%), Positives = 73/169 (42%), Gaps = 7/169 (4%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
V + D GR PL A S +D LL+ I L +D+ G + + A G ++++
Sbjct: 194 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL---MDKEGLTALSWACLKGHLSVV 250
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAA 149
L+++ D NG T L LA VVQ LV+ GA + D G PL RA
Sbjct: 251 RSLVDNGAAT--DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAV 308
Query: 150 ASGSVGIVSILCDKNSPVNIKD--KNGWSPLFHALAEGHGDVAVTLVNK 196
+ +V L K S + D P A+A D+ + L++K
Sbjct: 309 GCPNTSVVVTLLKKRSQDRLSDVXSRPRGPATWAMAPSKPDIMIILLSK 357
Score = 53.9 bits (128), Expect = 2e-07
Identities = 31/79 (39%), Positives = 43/79 (54%)
Query: 108 GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV 167
G TAL A + L V +LL+E+GA+V + G +PL G IV +L + V
Sbjct: 135 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 194
Query: 168 NIKDKNGWSPLFHALAEGH 186
N+ DK G +PL A +EGH
Sbjct: 195 NMADKQGRTPLMMAASEGH 213
Score = 53.5 bits (127), Expect = 2e-07
Identities = 31/72 (43%), Positives = 41/72 (56%)
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
+V LL+E GA+V G PL AAA+G + IV +LC K + V+ DKNG L HA
Sbjct: 1 MVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAA 60
Query: 183 AEGHGDVAVTLV 194
GH +V L+
Sbjct: 61 LRGHLEVVKFLI 72
>7301583 [R] KOG0504 FOG: Ankyrin repeat
Length = 1162
Score = 77.0 bits (188), Expect = 2e-14
Identities = 58/206 (28%), Positives = 93/206 (44%), Gaps = 34/206 (16%)
Query: 22 ILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID----------------- 64
+LS +V V+D DGR PL WA S + L+ +++
Sbjct: 175 LLSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRG 234
Query: 65 ----LDT----------ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGIT 110
+DT ++D +G + +H A ++G +LL+ +PN Q G T
Sbjct: 235 HTECIDTLIGLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEADPN--RQDRKGRT 292
Query: 111 ALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVS-ILCDKNSPVNI 169
H CSK ++LL ERGA++ +++ G LPLH AAASG ++ +L + VN
Sbjct: 293 PAHCGCSKGQFETLKLLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLAQRPKQVNT 352
Query: 170 KDKNGWSPLFHALAEGHGDVAVTLVN 195
+G S L A A + D+ L++
Sbjct: 353 TSNDGRSLLHIAAANDYTDMCKLLLD 378
Score = 55.5 bits (132), Expect = 6e-08
Identities = 55/188 (29%), Positives = 84/188 (44%), Gaps = 25/188 (13%)
Query: 27 PGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSV 86
P ++ D+DG PLH AV Q N+ + L K D++ + D G S VH A+ G V
Sbjct: 61 PELLESADEDGFTPLHLAVI--QGNLAMVNLLLANKADVNAV-DNEGHSVVHWATVCGEV 117
Query: 87 TILEKLLNHTVEPNLDLQANNGITALHLAC-------------------SKKHLNVVQLL 127
L +L ++ NG T LH A S+ L ++ +L
Sbjct: 118 ESLRAVL--AAGASVAKPDANGGTPLHYAAQMCGASKQDSKQQASSSNSSRLSLEILGIL 175
Query: 128 VERG-ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
+ +SV ++D G+ PL AA++GS V L + V DK+G + L A + GH
Sbjct: 176 LSHPQSSVDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESSDKDGLTALHCAGSRGH 235
Query: 187 GDVAVTLV 194
+ TL+
Sbjct: 236 TECIDTLI 243
>Hs13899329 [R] KOG0504 FOG: Ankyrin repeat
Length = 854
Score = 75.5 bits (184), Expect = 6e-14
Identities = 60/184 (32%), Positives = 89/184 (47%), Gaps = 5/184 (2%)
Query: 8 HAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDT 67
H A G +Q +LS+ V+ KD+ G LH A F +++ LL + T
Sbjct: 75 HDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDP--T 132
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
+ G P+H A++ G L L+ H E ++ Q NG T L+LAC + HL V Q L
Sbjct: 133 AATDMGALPIHYAAAKGDFPSLRLLVEHYPE-GVNAQTKNGATPLYLACQEGHLEVTQYL 191
Query: 128 V-ERGASVRIKDGLGQLPLHRAAASG-SVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
V E GA + G PLH AA G S IV ++ + ++ +DK+G + + A + G
Sbjct: 192 VQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRG 251
Query: 186 HGDV 189
H V
Sbjct: 252 HTKV 255
Score = 67.0 bits (162), Expect = 2e-11
Identities = 45/181 (24%), Positives = 89/181 (48%), Gaps = 6/181 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
+H A GD ++ ++ +P V + +G PL+ A Q+ +++ +++ D
Sbjct: 142 IHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC---QEGHLEVTQYLVQECGAD 198
Query: 67 T-ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
G +P+H A+ +G ++ L++ T + +L Q +G TA+H A S+ H V+
Sbjct: 199 PHARAHDGMTPLHAAAQMGHSPVIVWLVSCT-DVSLSEQDKDGATAMHFAASRGHTKVLS 257
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
L+ G + D G PLH AA +G + IL + ++++D++G++ + G
Sbjct: 258 WLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNG 316
Query: 186 H 186
H
Sbjct: 317 H 317
Score = 60.5 bits (145), Expect = 2e-09
Identities = 45/127 (35%), Positives = 64/127 (49%), Gaps = 3/127 (2%)
Query: 72 SGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERG 131
+G +P H AS+ G + L+ LL+ D + N+G T LHLA H VV L+ G
Sbjct: 69 NGATPAHDASATGHLACLQWLLSQGGCRVQD-KDNSGATVLHLAARFGHPEVVNWLLHHG 127
Query: 132 AS-VRIKDGLGQLPLHRAAASGSVGIVSILCDKNSP-VNIKDKNGWSPLFHALAEGHGDV 189
+G LP+H AAA G + +L + VN + KNG +PL+ A EGH +V
Sbjct: 128 GGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEV 187
Query: 190 AVTLVNK 196
LV +
Sbjct: 188 TQYLVQE 194
>7301689 [R] KOG0504 FOG: Ankyrin repeat
Length = 2119
Score = 73.9 bits (180), Expect = 2e-13
Identities = 59/179 (32%), Positives = 83/179 (45%), Gaps = 8/179 (4%)
Query: 19 VQQILSEFPGAVKVKDDDGRYPLHWAV---SFQQDNIIDILLSYMKKIDLDTILDESGWS 75
+ +IL E V D DGR L A S +I LL + D LD G S
Sbjct: 1398 IVEILLENGANVNHLDLDGRSALCVAALCGSSGYSKVISTLLDHGANTDQ---LDNDGMS 1454
Query: 76 PVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVR 135
P+ ++S G+ + E LL + +P DL G T L AC+ H VV+LL+ G +
Sbjct: 1455 PLLVSSFEGNAEVCELLLENAADP--DLADFMGRTPLWAACTAGHATVVKLLLFWGCGID 1512
Query: 136 IKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
D G+ L AA G+V V L D+ +D GW+PL +A EG +V + L+
Sbjct: 1513 CMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYAAFEGFHEVCLQLL 1571
Score = 72.4 bits (176), Expect = 5e-13
Identities = 62/221 (28%), Positives = 108/221 (48%), Gaps = 19/221 (8%)
Query: 6 LLHAACMNGDTEKVQQILS--EFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSY---- 59
L+H +G+ + +++ L+ + P ++++D +G+ L+ A ++ +LLS+
Sbjct: 1238 LIHILANDGNHQLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPC 1297
Query: 60 ------MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALH 113
MK++D++ D GW+P+ AS G ++ L+ +DL G TAL
Sbjct: 1298 NDGTGRMKRVDVNHA-DRDGWTPLRSASWGGHSEVVRLLIAQPA-CKIDLADKEGRTALR 1355
Query: 114 LACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKN 173
A H ++++LL+E GA V D G+ L A+ G IV IL + + VN D +
Sbjct: 1356 AAAWSGHEDILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLD 1415
Query: 174 GWSPLFHAL---AEGHGDVAVTLVNKYHALWEGETDNDDLS 211
G S L A + G+ V TL++ H + DND +S
Sbjct: 1416 GRSALCVAALCGSSGYSKVISTLLD--HGANTDQLDNDGMS 1454
Score = 59.3 bits (142), Expect = 4e-09
Identities = 48/188 (25%), Positives = 86/188 (45%), Gaps = 4/188 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G VQ +L V K DG+ A + ++ LL + ++
Sbjct: 1588 LHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHMDTVEFLLKFCCDVNSK 1647
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D + ++I + + I++ LL+ T ++++ + G TALH+A + H ++V+
Sbjct: 1648 ---DADSRTTLYILALENKLEIVKYLLDMT-NVDVNIPDSEGRTALHVAAWQGHADMVKT 1703
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E GA V D + PLH A G+ +++IL + + K G + L + EGH
Sbjct: 1704 LIEAGADVNSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACKQGATALGISAQEGH 1763
Query: 187 GDVAVTLV 194
+ L+
Sbjct: 1764 EKCVIALL 1771
Score = 54.7 bits (130), Expect = 1e-07
Identities = 55/204 (26%), Positives = 94/204 (45%), Gaps = 11/204 (5%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L AA +G E + ++L E V D GR L A +I++ILL ++
Sbjct: 1354 LRAAAWSGH-EDILKLLIESGADVNSVDRQGRTSLIAASYMGHYDIVEILLENGANVNH- 1411
Query: 67 TILDESGWSPVHIASSIGSV---TILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
LD G S + +A+ GS ++ LL+H N D N+G++ L ++ + + V
Sbjct: 1412 --LDLDGRSALCVAALCGSSGYSKVISTLLDHGA--NTDQLDNDGMSPLLVSSFEGNAEV 1467
Query: 124 VQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
+LL+E A + D +G+ PL A +G +V +L ++ D G + L A
Sbjct: 1468 CELLLENAADPDLADFMGRTPLWAACTAGHATVVKLLLFWGCGIDCMDSEGRTVLSIGAA 1527
Query: 184 EGHGDVAVTLVNKYHALWEGETDN 207
+G+ + L+++ L E DN
Sbjct: 1528 QGNVETVRQLLDR--GLDETHRDN 1549
Score = 53.9 bits (128), Expect = 2e-07
Identities = 39/123 (31%), Positives = 61/123 (48%), Gaps = 22/123 (17%)
Query: 73 GWSPVHIASSIGSVTILEKLLNHTVEP-NLDLQANNGITALHLACSKKHLNVVQLLVERG 131
G + +HI ++ G+ +LE+ LN P +L+++ NG TAL++A HL VV+LL+
Sbjct: 1235 GKALIHILANDGNHQLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLL--S 1292
Query: 132 ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAV 191
S DG G++ K VN D++GW+PL A GH +V
Sbjct: 1293 FSQPCNDGTGRM-------------------KRVDVNHADRDGWTPLRSASWGGHSEVVR 1333
Query: 192 TLV 194
L+
Sbjct: 1334 LLI 1336
Score = 52.4 bits (124), Expect = 5e-07
Identities = 57/231 (24%), Positives = 91/231 (38%), Gaps = 22/231 (9%)
Query: 9 AACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTI 68
A C + KV L + D+DG PL + + ++LL DL
Sbjct: 1424 ALCGSSGYSKVISTLLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDL--- 1480
Query: 69 LDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV 128
D G +P+ A + G T+++ LL +D + G T L + ++ ++ V+ L+
Sbjct: 1481 ADFMGRTPLWAACTAGHATVVKLLLFWGC--GIDCMDSEGRTVLSIGAAQGNVETVRQLL 1538
Query: 129 ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGD 188
+RG +D G PLH AA G + L + + ++ D G + L A EG
Sbjct: 1539 DRGLDETHRDNAGWTPLHYAAFEGFHEVCLQLLESGAKIDECDNEGKTALHLAAQEGRLH 1598
Query: 189 VAVTLVN--------KYH--------ALWEGETDNDDLSIDKICVDAKVKD 223
L++ K H A EG D + + K C D KD
Sbjct: 1599 CVQALLDIHSSFVDQKAHDGKTAFRLACLEGHMDTVEFLL-KFCCDVNSKD 1648
>Hs14731279 [R] KOG0504 FOG: Ankyrin repeat
Length = 743
Score = 73.6 bits (179), Expect = 2e-13
Identities = 62/200 (31%), Positives = 96/200 (48%), Gaps = 13/200 (6%)
Query: 14 GDTEKVQQILSEFPGAVKVKDDDGRYPLHWAV-----SFQQDNIIDILLSYMKKIDLDTI 68
G E V+ +L + V +D DGR L A S +++ +L+ ++D
Sbjct: 2 GHREIVEHLL-DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH--- 57
Query: 69 LDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV 128
D+ G +P+ +A+ G V +++ LL + +D NNG T L A S H +VV L+
Sbjct: 58 CDKDGMTPLLVAAYEGHVDVVDLLLEGGAD--VDHTDNNGRTPLLAAASMGHASVVNTLL 115
Query: 129 ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGD 188
GA+V D G+ L A+A G+V +V L D+ N +D GW+PL A EGH
Sbjct: 116 FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRL 175
Query: 189 VAVTLVNKYHALWEGETDND 208
+ L+ + E DND
Sbjct: 176 ICEALIEQ--GARTNEIDND 193
Score = 70.5 bits (171), Expect = 2e-12
Identities = 52/175 (29%), Positives = 87/175 (49%), Gaps = 5/175 (2%)
Query: 19 VQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVH 78
V +L E V D++GR PL A S ++++ LL + +D +D G + +
Sbjct: 77 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS---IDSEGRTVLS 133
Query: 79 IASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKD 138
IAS+ G+V ++ LL+ ++ N A G T LH+A + H + + L+E+GA D
Sbjct: 134 IASAQGNVEVVRTLLDRGLDENHRDDA--GWTPLHMAAFEGHRLICEALIEQGARTNEID 191
Query: 139 GLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTL 193
G++P A+ G V IL + S ++ + +G + L A EGH D+ L
Sbjct: 192 NDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 246
Score = 68.6 bits (166), Expect = 7e-12
Identities = 47/130 (36%), Positives = 66/130 (50%), Gaps = 8/130 (6%)
Query: 83 IGSVTILEKLLNHTVEPN---LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG 139
+G I+E LL+H E N +D + + AL + SK H +VV LL++RGA V D
Sbjct: 1 MGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDK 60
Query: 140 LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHA 199
G PL AA G V +V +L + + V+ D NG +PL A + GH V TL+
Sbjct: 61 DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL----- 115
Query: 200 LWEGETDNDD 209
W D+ D
Sbjct: 116 FWGAAVDSID 125
Score = 65.5 bits (158), Expect = 6e-11
Identities = 51/164 (31%), Positives = 80/164 (48%), Gaps = 6/164 (3%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL 93
D DG PL A +++D+LL +D D +G +P+ A+S+G +++ LL
Sbjct: 59 DKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT---DNNGRTPLLAAASMGHASVVNTLL 115
Query: 94 NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGS 153
+D + G T L +A ++ ++ VV+ L++RG +D G PLH AA G
Sbjct: 116 FWGAA--VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGH 173
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGD-VAVTLVNK 196
I L ++ + N D +G P A EGH D V + L NK
Sbjct: 174 RLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 217
Score = 62.4 bits (150), Expect = 5e-10
Identities = 49/174 (28%), Positives = 81/174 (46%), Gaps = 5/174 (2%)
Query: 21 QILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIA 80
QIL E + + DGR L A +I+++L S+ ++ D G ++I
Sbjct: 211 QILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK---DADGRPTLYIL 267
Query: 81 SSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGL 140
+ +T+ E L + N++ G TALH++C + H+ +VQ+L+ A V D
Sbjct: 268 ALENQLTMAEYFLENGA--NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE 325
Query: 141 GQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
+ L AA G V +V +L + + V+ G + L A EGH DV L+
Sbjct: 326 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL 379
Score = 58.9 bits (141), Expect = 6e-09
Identities = 53/194 (27%), Positives = 88/194 (45%), Gaps = 9/194 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
L A + G + V+ + S GA V KD DGR L+ Q + + L ++
Sbjct: 231 LRVAALEGHRDIVELLFSH--GADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEA 288
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
D G + +H++ G + +++ L+ + + N N +AL A + H+ VVQ
Sbjct: 289 S---DAEGRTALHVSCWQGHMEMVQVLIAYHADVNA--ADNEKRSALQSAAWQGHVKVVQ 343
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL+E GA V G L AA G + +V +L + + N D+ G + + A G
Sbjct: 344 LLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNG 403
Query: 186 HGDVAVTLVNKYHA 199
H + + L+ KY A
Sbjct: 404 HSQI-IKLLEKYGA 416
Score = 55.5 bits (132), Expect = 6e-08
Identities = 41/148 (27%), Positives = 69/148 (45%), Gaps = 9/148 (6%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
V+ D +GR LH + ++ +L++Y ++ D S + A+ G V ++
Sbjct: 286 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNA---ADNEKRSALQSAAWQGHVKVV 342
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAA 149
+ L+ H +D N G TAL +A + H++VVQ+L+E GA D G+ + AA
Sbjct: 343 QLLIEHGAV--VDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAA 400
Query: 150 ASGSVGIVSILCDKNSPVNIKDKNGWSP 177
+G I+ +L NG SP
Sbjct: 401 KNGHSQIIKLL----EKYGASSLNGCSP 424
>Hs14149803 [U] KOG2319 Vacuolar assembly/sorting protein VPS9
Length = 1050
Score = 73.6 bits (179), Expect = 2e-13
Identities = 60/202 (29%), Positives = 96/202 (46%), Gaps = 14/202 (6%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKV--KDDDGRYPLHWAVSFQQDNIIDILLSYMKKI 63
+ H C D EK+ P V +DD G PLH A Q ++ID+L+S K
Sbjct: 430 MCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVS---KG 486
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
+ D G +P+H+A G ++ LL++ + + ++Q NNG T LHLAC+ H +
Sbjct: 487 AMVNATDYHGATPLHLACQKGYQSVTLLLLHY--KASAEVQDNNGNTPLHLACTYGHEDC 544
Query: 124 VQLLV---ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFH 180
V+ LV + I + G PLH AA G G++ L + I+++ +PL
Sbjct: 545 VKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKC 604
Query: 181 ALAEGHGDVAVTLVNKYHALWE 202
AL ++++ YH +E
Sbjct: 605 AL----NSKILSVMEAYHLSFE 622
Score = 61.2 bits (147), Expect = 1e-09
Identities = 49/169 (28%), Positives = 77/169 (44%), Gaps = 10/169 (5%)
Query: 8 HAACMNGDTEKVQQILSEFPGA---VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID 64
H C Q+ L++ P + V V DG PLH A + ++I +LL +
Sbjct: 712 HPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIRLLLKHGANAG 771
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNL-DLQANNGITALHLACSKKHLNV 123
D++ P+H+A G +++ LL+ +PN DL N T L ACS H +
Sbjct: 772 ARNA-DQA--VPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGN---TPLIYACSGGHHEL 825
Query: 124 VQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDK 172
V LL++ GAS+ + G LH A V +V +L + V + +K
Sbjct: 826 VALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNK 874
Score = 60.1 bits (144), Expect = 3e-09
Identities = 35/119 (29%), Positives = 57/119 (47%), Gaps = 2/119 (1%)
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
+ + G SP+H+A+ G ++ LL H N + + LHLAC + H VV+ L
Sbjct: 739 VTSQDGSSPLHVAALHGRADLIRLLLKHGA--NAGARNADQAVPLHLACQQGHFQVVKCL 796
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
++ A KD G PL A + G +V++L + +N + G + L A+ E H
Sbjct: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKH 855
Score = 55.1 bits (131), Expect = 8e-08
Identities = 27/94 (28%), Positives = 53/94 (55%)
Query: 101 LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
+++ + +G + LH+A ++++LL++ GA+ ++ +PLH A G +V L
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIRLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
Query: 161 CDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
D N+ N KD +G +PL +A + GH ++ L+
Sbjct: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLL 830
>Hs7657238 [R] KOG0504 FOG: Ankyrin repeat
Length = 1065
Score = 73.2 bits (178), Expect = 3e-13
Identities = 52/188 (27%), Positives = 85/188 (44%), Gaps = 3/188 (1%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G + V +L D G PLH+A Q N + + ++K +
Sbjct: 259 LHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAA---QSNFAETVKVFLKHPSVK 315
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D G + A+ GS +L +L+ + ++++ G TALH A H++ V+L
Sbjct: 316 DDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKL 375
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+E A V D + PL RA G ++ L + V++ D++G S L A G+
Sbjct: 376 LLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435
Query: 187 GDVAVTLV 194
DV L+
Sbjct: 436 ADVCQILI 443
Score = 72.4 bits (176), Expect = 5e-13
Identities = 57/191 (29%), Positives = 89/191 (45%), Gaps = 8/191 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A +G+ V + S + D+ R PLHWA I+ +LL K +
Sbjct: 225 LHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIP 284
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNH-TVEPNLDLQANNGITALHLACSKKHLNVVQ 125
+ D G +P+H A+ ++ L H +V+ + DL+ G T+ A K +V++
Sbjct: 285 S--DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLE---GRTSFMWAAGKGSDDVLR 339
Query: 126 --LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
L ++ + + D G LH AA SG V V +L + N+ V+ D +PLF A
Sbjct: 340 TMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACE 399
Query: 184 EGHGDVAVTLV 194
GH DV TL+
Sbjct: 400 MGHKDVIQTLI 410
Score = 68.2 bits (165), Expect = 9e-12
Identities = 55/234 (23%), Positives = 103/234 (43%), Gaps = 35/234 (14%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + E V+ L P D +GR WA D+++ +LS ID++
Sbjct: 293 LHYAAQSNFAETVKVFLKH-PSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDIN 351
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPN-------------------------- 100
+ D+ G + +H A+ G V+ ++ LL + + +
Sbjct: 352 -MADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLI 410
Query: 101 -----LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVG 155
+DL +G + LH A + +V Q+L+E + ++D G+ PL AA G +
Sbjct: 411 KGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYIN 470
Query: 156 IVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDD 209
+++L + N+ NI+DK G + L + G+ D L++ A + + +N++
Sbjct: 471 CMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLD--FAAFPNQMENNE 522
Score = 55.5 bits (132), Expect = 6e-08
Identities = 56/225 (24%), Positives = 93/225 (40%), Gaps = 36/225 (16%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSY---MKKI 63
+HAA +NGD +Q+++ +D GR PL + V + + D LL + K
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 64 DLDT-------------------ILDESGW--------SPVHIASSIGSVTILEKLLNHT 96
D + + W +P+H+ + S L LL
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137
Query: 97 VEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAA------A 150
+D Q N TALH + + V+LL++ +++ I D G++PLH AA A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 151 SGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
+V + S +N +D G +PL A+A+G+ V L +
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTS 242
>Hs16159328 [R] KOG0504 FOG: Ankyrin repeat
Length = 683
Score = 72.8 bits (177), Expect = 4e-13
Identities = 58/195 (29%), Positives = 82/195 (41%), Gaps = 6/195 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH M G E VQ +L + ++ KD GR PLH+A + + LL +
Sbjct: 414 LHRGIMTGHEECVQMLLEQ-EVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDC 472
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D G++P+H A G+ +E LL N T LH A H N L
Sbjct: 473 CFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKF---IGNPFTPLHCAIINDHGNCASL 529
Query: 127 LVER--GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
L+ + V +D G+ PLH AA + V + +L ++PVN D +G + L A
Sbjct: 530 LLGAIDSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAEN 589
Query: 185 GHGDVAVTLVNKYHA 199
G LVN A
Sbjct: 590 GQAGAVDILVNSAQA 604
Score = 69.3 bits (168), Expect = 4e-12
Identities = 59/198 (29%), Positives = 90/198 (44%), Gaps = 17/198 (8%)
Query: 7 LHAACMNGD----TEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLS---Y 59
LH A G +E +Q LSE K D+ G PLHWA +N I++LL +
Sbjct: 447 LHYAAARGHATWLSELLQMALSEEDCCFK--DNQGYTPLHWACYNGNENCIEVLLEQKCF 504
Query: 60 MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKK 119
K I + ++P+H A LL + + + G T LH A
Sbjct: 505 RKFIG-------NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFAD 557
Query: 120 HLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDK-NSPVNIKDKNGWSPL 178
H+ +QLL+ A V D G+ L AA +G G V IL + + + +KDK+ +PL
Sbjct: 558 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 617
Query: 179 FHALAEGHGDVAVTLVNK 196
A ++GH A+ +++K
Sbjct: 618 HLACSKGHEKCALLILDK 635
Score = 67.4 bits (163), Expect = 2e-11
Identities = 51/181 (28%), Positives = 85/181 (46%), Gaps = 4/181 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A NG + ++ +L + ++D+ GR L A ++ L++ I +
Sbjct: 278 LHLAAYNGHHQALEVLLQSLVD-LDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVK 336
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPN-LDLQANNGITALHLACSKKHLNVVQ 125
+ + +P+H + G L LL P +D++ G T L LA + H++ V
Sbjct: 337 DNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 394
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL+E+ A+V D LG LHR +G V +L ++ + KD G +PL +A A G
Sbjct: 395 LLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARG 454
Query: 186 H 186
H
Sbjct: 455 H 455
Score = 62.8 bits (151), Expect = 4e-10
Identities = 54/204 (26%), Positives = 88/204 (42%), Gaps = 44/204 (21%)
Query: 32 VKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGW--SPVHIASSIGSVTIL 89
++D +G +H+A ++ +++LL ++ + +SG SP+H+A+ G L
Sbjct: 234 IRDKEGYNSIHYAAAYGHRQCLELLL---ERTNSGFEESDSGATKSPLHLAAYNGHHQAL 290
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGAS---------------- 133
E LL V+ LD++ G TAL LA K H V+ L+ +GAS
Sbjct: 291 EVLLQSLVD--LDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVKDNVTKRTPLHAS 348
Query: 134 ---------------------VRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDK 172
V +KD GQ PL A A G + VS+L +K + V+ D
Sbjct: 349 VINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDI 408
Query: 173 NGWSPLFHALAEGHGDVAVTLVNK 196
G + L + GH + L+ +
Sbjct: 409 LGCTALHRGIMTGHEECVQMLLEQ 432
Score = 62.0 bits (149), Expect = 7e-10
Identities = 49/172 (28%), Positives = 83/172 (47%), Gaps = 8/172 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A +N +L + V +DD GR PLH A + +LL + ++
Sbjct: 515 LHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNA 574
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
+D SG + + +A+ G ++ L+N + + +L ++ + T LHLACSK H
Sbjct: 575 ---VDNSGKTALMMAAENGQAGAVDILVN-SAQADLTVKDKDLNTPLHLACSKGHEKCAL 630
Query: 126 LLVER---GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
L++++ + + K+ Q PLH AA +G +V L K + V D+NG
Sbjct: 631 LILDKIQDESLINEKNNALQTPLHVAARNGLKVVVEELLAKGACVLAVDENG 682
Score = 50.8 bits (120), Expect = 2e-06
Identities = 46/182 (25%), Positives = 76/182 (41%), Gaps = 25/182 (13%)
Query: 21 QILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSY---MKKIDLDTILDESGWSPV 77
Q L + G + D DG PLH A + + +I+ L++ K + ++ P+
Sbjct: 12 QTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMF------PL 65
Query: 78 HIASSIGSVTILEKLLN--------------HTVEPNLDLQANN--GITALHLACSKKHL 121
H+A+ KLL+ H + ++ + G T LH A + ++
Sbjct: 66 HLAALNAHSDCCRKLLSSGQKYSIVSLFSNEHVLSAGFEIDTPDKFGRTCLHAAAAGGNV 125
Query: 122 NVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
++LL GA KD G+ PLH AAA+ + L + VN D G + L +A
Sbjct: 126 ECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 185
Query: 182 LA 183
A
Sbjct: 186 AA 187
Score = 48.1 bits (113), Expect = 1e-05
Identities = 42/147 (28%), Positives = 67/147 (45%), Gaps = 26/147 (17%)
Query: 69 LDESGWSPVHIASSIGSVTILEKLLN----------HTVEPNLDLQANNGITALHLACSK 118
+D+ G +P+H+A+ G ++ L+ H++ P L L A N H C +
Sbjct: 24 VDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFP-LHLAALNA----HSDCCR 78
Query: 119 KHLN------VVQL-----LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV 167
K L+ +V L ++ G + D G+ LH AAA G+V + +L +
Sbjct: 79 KLLSSGQKYSIVSLFSNEHVLSAGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF 138
Query: 168 NIKDKNGWSPLFHALAEGHGDVAVTLV 194
+ KDK G +PL +A A H TLV
Sbjct: 139 HKKDKCGRTPLHYAAANCHFHCIETLV 165
>Hs4885087 [R] KOG0504 FOG: Ankyrin repeat
Length = 446
Score = 72.4 bits (176), Expect = 5e-13
Identities = 60/197 (30%), Positives = 96/197 (48%), Gaps = 9/197 (4%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGA---VKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
D LH A + G+ V ++++ F + + ++ + PLH AV +++ +L++
Sbjct: 128 DTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAG 187
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN--GITALHLACSK 118
LD G + H+A S T L LL+ LDL+A N G+TALH+A +
Sbjct: 188 AS---PMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 244
Query: 119 KHLNVVQLLVERGASVRIKD-GLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSP 177
+ VQLL+ERGA + D G+ PL A + S+ +V +L + VN + +G S
Sbjct: 245 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 304
Query: 178 LFHALAEGHGDVAVTLV 194
L A G + TLV
Sbjct: 305 LHSASGRGLLPLVRTLV 321
>Hs13376842 [M] KOG4177 Ankyrin
Length = 1166
Score = 71.6 bits (174), Expect = 8e-13
Identities = 66/244 (27%), Positives = 99/244 (40%), Gaps = 63/244 (25%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRY--PLHWAVSFQQDNIIDILLSYMKKID 64
L AC NGD E+V+++++ P V +D GR PLH+A F + ++++ LL +
Sbjct: 28 LFEACRNGDVERVKRLVT--PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
D+ G P+H A S G ++ LL H +PN + N T LH A K ++V
Sbjct: 86 AR---DDGGLIPLHNACSFGHAEVVNLLLRHGADPN--ARDNWNYTPLHEAAIKGKIDVC 140
Query: 125 QLLVERGA--SVRIKDGLGQLPL------------------------------------- 145
+L++ GA ++R DG L L
Sbjct: 141 IVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPL 200
Query: 146 ---------------HRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVA 190
H AA V IV +L + V+ KDK PL +A + GH +V
Sbjct: 201 NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260
Query: 191 VTLV 194
LV
Sbjct: 261 ELLV 264
Score = 67.0 bits (162), Expect = 2e-11
Identities = 64/253 (25%), Positives = 102/253 (40%), Gaps = 59/253 (23%)
Query: 19 VQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVH 78
V + L + V KD G PLH A S+ + ++L+ + ++ + D ++P+H
Sbjct: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN---VADLWKFTPLH 597
Query: 79 IASSIGSVTILEKLLNHTVEPN---------LDL--------------------QANNGI 109
A++ G I + LL H +P LDL A G
Sbjct: 598 EAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGC 657
Query: 110 -----------------------TALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLH 146
T LHLA +L V + L++ GA V +D G +PLH
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
Query: 147 RAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV----NKYHALWE 202
AA+ G V + ++L N+ VN DK ++PL A +G + L+ + E
Sbjct: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
Query: 203 GETDNDDLSIDKI 215
G+T D +S D +
Sbjct: 778 GQTPLDLVSADDV 790
Score = 65.9 bits (159), Expect = 5e-11
Identities = 61/242 (25%), Positives = 97/242 (39%), Gaps = 58/242 (23%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A G + V+ +L GA V+ +DD G PLH A SF ++++LL +
Sbjct: 62 LHFAAGFGRKDVVEYLLQN--GANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGAD--- 116
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEP-------------------------- 99
D ++P+H A+ G + + LL H EP
Sbjct: 117 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEY 176
Query: 100 ------------------------NLDLQANNG--ITALHLACSKKHLNVVQLLVERGAS 133
N++ A++G T LHLA + +VQLL++ GA
Sbjct: 177 KKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD 236
Query: 134 VRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTL 193
V KD +PLH A + G + +L + VN D ++PL A ++ +V L
Sbjct: 237 VHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 296
Query: 194 VN 195
++
Sbjct: 297 LS 298
Score = 64.3 bits (155), Expect = 1e-10
Identities = 36/104 (34%), Positives = 55/104 (52%), Gaps = 2/104 (1%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
+P+H A+ V+++E LL H + + + G+ LH ACS H V +LLV+ GA V
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQHGAD--VHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVV 585
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
+ D PLH AAA G I +L + K+++G +PL
Sbjct: 586 NVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629
Score = 55.5 bits (132), Expect = 6e-08
Identities = 34/115 (29%), Positives = 56/115 (48%), Gaps = 1/115 (0%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG 139
A+ G V ++KL D++ T LH A ++VV+ L++ GA V KD
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQS-TPLHFAAGYNRVSVVEYLLQHGADVHAKDK 557
Query: 140 LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
G +PLH A + G + +L + VN+ D ++PL A A+G ++ L+
Sbjct: 558 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612
Score = 48.5 bits (114), Expect = 8e-06
Identities = 37/115 (32%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
N++ + +T LH+A K H +VV+++V+ A V D LGQ LHRAA G + +
Sbjct: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRL 451
Query: 160 LCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDK 214
L NI G F AL G+ +V L+ + +L E D L K
Sbjct: 452 LLSYGCDPNIISLQG----FTALQMGNENVQ-QLLQEGISLGNSEADRQLLEAAK 501
>CE16523 [R] KOG0504 FOG: Ankyrin repeat
Length = 991
Score = 71.2 bits (173), Expect = 1e-12
Identities = 54/184 (29%), Positives = 90/184 (48%), Gaps = 10/184 (5%)
Query: 7 LHAACMNG----DTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKK 62
LH NG + + ++L E K++D +GR LH A ++ D + ++L
Sbjct: 561 LHLNLSNGSKQEENSETTKLLLEHNADCKIEDANGRVALHLA-AYHGDPCLQLILEKHPI 619
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
+D ++D G +P+ +A+S G + ++ L T + ++D NNG TAL A H
Sbjct: 620 VD---VMDNMGQTPLMLAASQGQLEAVQ-FLTKTAKADVDAIDNNGRTALQWAAINGHPE 675
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
VV+ L G+ KD G + LH A V +V L ++++ V KD+ G P+ A
Sbjct: 676 VVEFLCSVGSDEGHKDNDGAVALHYAVTHDHVELVKHLTNQHT-VEAKDRYGQHPMMIAA 734
Query: 183 AEGH 186
A G+
Sbjct: 735 ANGN 738
Score = 55.1 bits (131), Expect = 8e-08
Identities = 56/201 (27%), Positives = 84/201 (40%), Gaps = 16/201 (7%)
Query: 1 MGADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSF---QQDNIIDILL 57
M A F+ H + V ++ ++ V D G LH +S Q++N L
Sbjct: 529 MAAAFMCH--------KDVVSVIIQYGADVNAIDKSGATALHLNLSNGSKQEENSETTKL 580
Query: 58 SYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACS 117
D I D +G +H+A+ G + L H P +D+ N G T L LA S
Sbjct: 581 LLEHNADCK-IEDANGRVALHLAAYHGDPCLQLILEKH---PIVDVMDNMGQTPLMLAAS 636
Query: 118 KKHLNVVQLLVERG-ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWS 176
+ L VQ L + A V D G+ L AA +G +V LC S KD +G
Sbjct: 637 QGQLEAVQFLTKTAKADVDAIDNNGRTALQWAAINGHPEVVEFLCSVGSDEGHKDNDGAV 696
Query: 177 PLFHALAEGHGDVAVTLVNKY 197
L +A+ H ++ L N++
Sbjct: 697 ALHYAVTHDHVELVKHLTNQH 717
Score = 50.1 bits (118), Expect = 3e-06
Identities = 54/201 (26%), Positives = 86/201 (41%), Gaps = 12/201 (5%)
Query: 5 FLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID 64
F L A G+ E + + FP V L A + Q I+ +LL K +D
Sbjct: 426 FGLLTAAARGNIEMCRFLADHFPHLVASSCCGEWNALRSAACYGQLEILHLLLE--KGVD 483
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
+D S + + A+ G + ++ LL E +D + + TAL A H +VV
Sbjct: 484 VDEC-GHSDRTALRAAAWSGQLAAVQLLLQTGAE--VDRRDSEQRTALMAAAFMCHKDVV 540
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGS-----VGIVSILCDKNSPVNIKDKNGWSPLF 179
++++ GA V D G LH ++GS +L + N+ I+D NG L
Sbjct: 541 SVIIQYGADVNAIDKSGATALHLNLSNGSKQEENSETTKLLLEHNADCKIEDANGRVALH 600
Query: 180 HALAEGHGDVAVTLVNKYHAL 200
LA HGD + L+ + H +
Sbjct: 601 --LAAYHGDPCLQLILEKHPI 619
>Hs4505319 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 982
Score = 70.9 bits (172), Expect = 1e-12
Identities = 76/289 (26%), Positives = 123/289 (42%), Gaps = 71/289 (24%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
GA FL AAC +GDT++V+++L+ GA + + DG LH A + +++ L+
Sbjct: 59 GAVFL--AACSSGDTDEVRKLLAR--GADINTVNVDGLTALHQACIDENLDMVKFLVENR 114
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEK----------------------------- 91
++ D GW+P+H A+S G + I E
Sbjct: 115 ANVNQQ---DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKD 171
Query: 92 -LLNHTVEPNLDL----------------------------QANNGITALHLACSKKHLN 122
LL + +DL QA +G TALH+A +K +
Sbjct: 172 LLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
V++LL++ G + ++D G PLH AA G SIL + ++I++K G +P F
Sbjct: 232 VLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP-FDVA 290
Query: 183 AEGHGDVAVTLVNKYHAL-WEGETDNDDLSIDKICVDAKVKDYFLSKVE 230
EG + L K + L E ET N + D +++K++ F E
Sbjct: 291 DEGLVEHLELLQKKQNVLRSEKETRNKLIESD---LNSKIQSGFFKNKE 336
>Hs14195601 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 998
Score = 70.9 bits (172), Expect = 1e-12
Identities = 76/289 (26%), Positives = 123/289 (42%), Gaps = 71/289 (24%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
GA FL AAC +GDT++V+++L+ GA + + DG LH A + +++ L+
Sbjct: 59 GAVFL--AACSSGDTDEVRKLLAR--GADINTVNVDGLTALHQACIDENLDMVKFLVENR 114
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEK----------------------------- 91
++ D GW+P+H A+S G + I E
Sbjct: 115 ANVNQQ---DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKD 171
Query: 92 -LLNHTVEPNLDL----------------------------QANNGITALHLACSKKHLN 122
LL + +DL QA +G TALH+A +K +
Sbjct: 172 LLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
V++LL++ G + ++D G PLH AA G SIL + ++I++K G +P F
Sbjct: 232 VLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP-FDVA 290
Query: 183 AEGHGDVAVTLVNKYHAL-WEGETDNDDLSIDKICVDAKVKDYFLSKVE 230
EG + L K + L E ET N + D +++K++ F E
Sbjct: 291 DEGLVEHLELLQKKQNVLRSEKETRNKLIESD---LNSKIQSGFFKNKE 336
>Hs4507613 [M] KOG4177 Ankyrin
Length = 1327
Score = 70.5 bits (171), Expect = 2e-12
Identities = 59/207 (28%), Positives = 86/207 (41%), Gaps = 23/207 (11%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G + V+ +L + V +DD G PLH A SF ++ +LL
Sbjct: 220 LHFAAGFGRKDVVEHLL-QMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGAD---P 275
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNL------------DLQANNGITA--- 111
D ++P+H A+ G + + LL H +PN+ D A +T
Sbjct: 276 NARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYK 335
Query: 112 ----LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV 167
L A S ++ LL + DG PLH AA V IV +L + V
Sbjct: 336 KDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADV 395
Query: 168 NIKDKNGWSPLFHALAEGHGDVAVTLV 194
+ KDK G PL +A + GH +V L+
Sbjct: 396 HAKDKGGLVPLHNACSYGHYEVTELLL 422
Score = 70.1 bits (170), Expect = 2e-12
Identities = 56/173 (32%), Positives = 82/173 (47%), Gaps = 8/173 (4%)
Query: 17 EKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSP 76
E VQQILSE + ++ D Y L A + L S D L+ +P
Sbjct: 633 EAVQQILSE---STPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRD--LEGRHSTP 687
Query: 77 VHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRI 136
+H A+ V+++E LL+H + + + G+ LH ACS H V +LLV GASV +
Sbjct: 688 LHFAAGYNRVSVVEYLLHHGAD--VHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745
Query: 137 KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
D PLH AAA G I +L + K+++G +PL + EG D+
Sbjct: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL-DLVKEGDTDI 797
Score = 70.1 bits (170), Expect = 2e-12
Identities = 64/205 (31%), Positives = 92/205 (44%), Gaps = 19/205 (9%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSY-----MK 61
LH AC G E V ++L +V V D PLH A + + I +LL + K
Sbjct: 721 LHNACSYGHYE-VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779
Query: 62 KIDLDTILDE------------SGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI 109
D +T LD G + + A+ G + ++KL D Q N
Sbjct: 780 NRDGNTPLDLVKEGDTDIQDLLKGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNS- 838
Query: 110 TALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNI 169
T LHLA +L V + L+E GA V +D G +PLH AA+ G V I ++L N+ VN
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA 898
Query: 170 KDKNGWSPLFHALAEGHGDVAVTLV 194
DK ++PL A +G + L+
Sbjct: 899 TDKWAFTPLHEAAQKGRTQLCALLL 923
Score = 63.2 bits (152), Expect = 3e-10
Identities = 35/104 (33%), Positives = 54/104 (51%), Gaps = 2/104 (1%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
SP+H A+ G ++E LL + N+ + + G+ LH ACS H VV LL+ +GA
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQ--MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADP 275
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
+D PLH AA G + + +L + NI++ +G S L
Sbjct: 276 NARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSAL 319
Score = 57.4 bits (137), Expect = 2e-08
Identities = 34/121 (28%), Positives = 60/121 (49%), Gaps = 5/121 (4%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
+P+H+A+ ++ + E LL H + N Q G+ LH A S H+++ LL++ V
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNA--QDKGGLIPLHNAASYGHVDIAALLIKYNTCV 896
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
D PLH AA G + ++L + +K++ G +PL A A+ D+ L+
Sbjct: 897 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLI 953
Query: 195 N 195
+
Sbjct: 954 D 954
Score = 55.8 bits (133), Expect = 5e-08
Identities = 56/218 (25%), Positives = 90/218 (40%), Gaps = 31/218 (14%)
Query: 4 DFL--LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSY-- 59
DF+ LH A + V ++L + + D G+ LH A +LLSY
Sbjct: 557 DFMTPLHVAAERAHND-VMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGS 615
Query: 60 --------------MKKIDLDTILDESGWSPVHI---------ASSIGSVTILEKLLNHT 96
M + IL ES +P+ AS G + +++L +
Sbjct: 616 DPSIISLQGFTAAQMGNEAVQQILSES--TPIRTSDVDYRLLEASKAGDLETVKQLCSSQ 673
Query: 97 VEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGI 156
DL+ + T LH A ++VV+ L+ GA V KD G +PLH A + G +
Sbjct: 674 NVNCRDLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEV 732
Query: 157 VSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
+L + VN+ D ++PL A A+G ++ L+
Sbjct: 733 AELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
Score = 55.1 bits (131), Expect = 8e-08
Identities = 33/111 (29%), Positives = 58/111 (51%), Gaps = 1/111 (0%)
Query: 84 GSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQL 143
G V+ +++L++ N A + LH A +VV+ L++ GA+V +D G +
Sbjct: 193 GDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI 251
Query: 144 PLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
PLH A + G +VS+L + + N +D ++PL A +G DV + L+
Sbjct: 252 PLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
Score = 55.1 bits (131), Expect = 8e-08
Identities = 32/102 (31%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
+P+H+A+ V I++ LL H + + + G+ LH ACS H V +LL++ GA V
Sbjct: 371 TPLHLAAGYNRVRIVQLLLQHGAD--VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACV 428
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWS 176
D PLH AA+ V + S+L + + + +G S
Sbjct: 429 NAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKS 470
>Hs21264330_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 500
Score = 70.5 bits (171), Expect = 2e-12
Identities = 58/179 (32%), Positives = 86/179 (47%), Gaps = 7/179 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQ--DNIIDILLSYMKKID 64
LH A G E V+ L E V + D PLH A+S I+++L + ID
Sbjct: 80 LHVAVQRGFLEVVRA-LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTE-VPNID 137
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
+ T + G++ +H AS G + K+L + +D + +G TALHLA H V
Sbjct: 138 V-TATNSQGFTLLHHASLKGHALAVRKILARARQL-VDAKKEDGFTALHLAALNNHREVA 195
Query: 125 QLLVERG-ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
Q+L+ G V +++ Q PLH A VG+V +L D VN +D+ G + L AL
Sbjct: 196 QILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVAL 254
Score = 52.4 bits (124), Expect = 5e-07
Identities = 44/173 (25%), Positives = 70/173 (40%), Gaps = 22/173 (12%)
Query: 73 GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGA 132
G + + +A+ +G V ++ LL +DL + G TALH A ++L+ G
Sbjct: 10 GRTALQVAAYLGQVELIRLLLQ--ARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGC 67
Query: 133 SVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHG----- 187
+ LH A G + +V LC++ VN+ D + +PL A++ G G
Sbjct: 68 RADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIV 127
Query: 188 ---------DVAVTLVNKYHALWEGETDNDDLSIDKI------CVDAKVKDYF 225
DV T + L L++ KI VDAK +D F
Sbjct: 128 EVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKEDGF 180
>7301133 [T] KOG4369 RTK signaling protein MASK/UNC-44
Length = 2441
Score = 70.1 bits (170), Expect = 2e-12
Identities = 57/197 (28%), Positives = 103/197 (51%), Gaps = 10/197 (5%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKK 62
D L AC G E V+ +++ GA ++ +D G PL A + D ++DILL + +
Sbjct: 754 DTALTLACAGGHEELVELLINR--GANIEHRDKKGFTPLILAATAGHDKVVDILLKHSAE 811
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
++ + + + +P+ +A S G ++E LL +V N + + + T L LA S ++N
Sbjct: 812 LEAQS--ERTKDTPLSLACSGGRYEVVELLL--SVGANKEHRNVSDYTPLSLAASGGYVN 867
Query: 123 VVQLLVERGASVRIKDG--LGQLPLHRAAASGSVGIVSILCDKNSPVNIK-DKNGWSPLF 179
+++LL+ GA + + G LG PL AA +G V +L D+ S +N + + N + L
Sbjct: 868 IIKLLLSHGAEINSRTGSKLGISPLMLAAMNGHTPAVKLLLDQGSDINAQIETNRNTALT 927
Query: 180 HALAEGHGDVAVTLVNK 196
A +G +V L+++
Sbjct: 928 LACFQGRHEVVSLLLDR 944
Score = 67.4 bits (163), Expect = 2e-11
Identities = 52/189 (27%), Positives = 89/189 (46%), Gaps = 5/189 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQ-QDNIIDILLSYMKKIDL 65
L A MNG T V+ +L + + + + R FQ + ++ +LL ++
Sbjct: 892 LMLAAMNGHTPAVKLLLDQ-GSDINAQIETNRNTALTLACFQGRHEVVSLLLDRRANVEH 950
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
++G +P+ A+S G + + LL+ + N + TAL +A K H V+
Sbjct: 951 RA---KTGLTPLMEAASGGYIEVGRVLLDKGADVNAAPVPTSRDTALTIAADKGHQKFVE 1007
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
LL+ R ASV +K+ G PL AA G + +V +L D N+ ++ +D S L A +G
Sbjct: 1008 LLLSRNASVEVKNKKGNSPLWLAAHGGHLSVVELLYDHNADIDSQDNRRVSCLMAAFRKG 1067
Query: 186 HGDVAVTLV 194
H + +V
Sbjct: 1068 HTKIVKWMV 1076
Score = 50.1 bits (118), Expect = 3e-06
Identities = 36/111 (32%), Positives = 62/111 (55%), Gaps = 6/111 (5%)
Query: 93 LNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASG 152
L+ T+E + + ++N+ TAL LAC+ H +V+LL+ RGA++ +D G PL AA +G
Sbjct: 739 LDKTIEIDSETESNHD-TALTLACAGGHEELVELLINRGANIEHRDKKGFTPLILAATAG 797
Query: 153 SVGIVSILCDKNSPVNIK-DKNGWSPLFHALAEGHGDVAVTLV----NKYH 198
+V IL ++ + + ++ +PL A + G +V L+ NK H
Sbjct: 798 HDKVVDILLKHSAELEAQSERTKDTPLSLACSGGRYEVVELLLSVGANKEH 848
>7291939 [R] KOG0510 Ankyrin repeat protein
Length = 904
Score = 69.3 bits (168), Expect = 4e-12
Identities = 46/150 (30%), Positives = 77/150 (50%), Gaps = 10/150 (6%)
Query: 38 RYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTV 97
R LH+A+ + ++ILL Y + + E+ P+H AS+ G ++ LL+H
Sbjct: 207 RSALHYAIDVNAVDCVEILLKYGADPNTPQVYTET---PLHTASAAGFAKCVQLLLSH-- 261
Query: 98 EPNLDLQANNG---ITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSV 154
N D+++ G +TALHLA ++ +LL+E A V ++ Q PLH A S S+
Sbjct: 262 --NADVRSQFGEGKVTALHLAAENDYVECARLLLEHRAEVDCRNASHQTPLHLACLSQSI 319
Query: 155 GIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
G V +L + VN ++G + L A+ +
Sbjct: 320 GTVDLLISYGANVNAVYRDGRTALHAAIVK 349
Score = 55.1 bits (131), Expect = 8e-08
Identities = 51/190 (26%), Positives = 77/190 (39%), Gaps = 19/190 (10%)
Query: 3 ADFLLHAACMN--GDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
AD L C + G E +L + V D GR PLH+A I +L
Sbjct: 104 ADCNLALICCSVFGSVENTLFLLKHYNADPNVADSRGRTPLHFACCRANAPIAKVL---- 159
Query: 61 KKIDLDTILDESGW------SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHL 114
LD D + W + +H A+S SV + LL N+ ++ +ALH
Sbjct: 160 ----LDFGADPNRWDARKEVTSLHCAASSKSVECILLLLRRKASINIGIEKR---SALHY 212
Query: 115 ACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
A ++ V++L++ GA + PLH A+A+G V +L N+ V + G
Sbjct: 213 AIDVNAVDCVEILLKYGADPNTPQVYTETPLHTASAAGFAKCVQLLLSHNADVRSQFGEG 272
Query: 175 WSPLFHALAE 184
H AE
Sbjct: 273 KVTALHLAAE 282
>7301359 [M] KOG4177 Ankyrin
Length = 1181
Score = 68.6 bits (166), Expect = 7e-12
Identities = 62/242 (25%), Positives = 98/242 (39%), Gaps = 63/242 (26%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRY--PLHWAVSFQQDNIIDILLSYMKKIDLDT 67
A GD + V++I+ P +V +D DGR+ PLH+A F + ++ LL + ++
Sbjct: 491 AAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEV---Y 547
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNL-DLQANNGITALHLACSKKHLNVVQL 126
D+ G P+H A S G + E L+ H N+ DL T LH A +K ++ +L
Sbjct: 548 AADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWK---FTPLHEAAAKGKYDICKL 604
Query: 127 LVERGA----------------------------------------------------SV 134
L++ GA S+
Sbjct: 605 LLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESI 664
Query: 135 RIKDGLGQ--LPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVT 192
+D G+ PLH AA + L + + VN +DK G PL +A + GH D+A
Sbjct: 665 NCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAAL 724
Query: 193 LV 194
L+
Sbjct: 725 LI 726
Score = 67.4 bits (163), Expect = 2e-11
Identities = 63/230 (27%), Positives = 102/230 (43%), Gaps = 23/230 (10%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSY------- 59
LH AC G E V ++L + V V D PLH A + + +I +LL +
Sbjct: 557 LHNACSYGHYE-VTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKK 615
Query: 60 ----------MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI 109
+K+ D D G S + A+ G++ +++L+ D Q N
Sbjct: 616 NRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNS- 674
Query: 110 TALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNI 169
T LHLA + + L+E GA V +D G +PLH A++ G + I ++L + VN
Sbjct: 675 TPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNA 734
Query: 170 KDKNGWSPLFHALAEGHGDVAVTLV----NKYHALWEGETDNDDLSIDKI 215
DK G++PL A +G + L+ + Y EG+T + + D +
Sbjct: 735 TDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDV 784
Score = 65.5 bits (158), Expect = 6e-11
Identities = 59/242 (24%), Positives = 98/242 (40%), Gaps = 56/242 (23%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G E V+ +L+ +++ D+ G +PLH SF ++ +LL K
Sbjct: 61 LHFAAGYGRREVVEFLLNS-GASIQACDEGGLHPLHNCCSFGHAEVVRLLL---KAGASP 116
Query: 67 TILDESGWSPVHIASSIGSVTILEKLL----NHTVEP----------------------- 99
D ++P+H A+S G V + LL NHT+
Sbjct: 117 NTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYR 176
Query: 100 -----------------------NLDLQANNG--ITALHLACSKKHLNVVQLLVERGASV 134
N++ A++G T LHLA + +V++L+ GA V
Sbjct: 177 KDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADV 236
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
KD G +PLH A + G + +L + VN D ++PL A ++ +V L+
Sbjct: 237 HAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLL 296
Query: 195 NK 196
++
Sbjct: 297 SR 298
Score = 64.3 bits (155), Expect = 1e-10
Identities = 49/153 (32%), Positives = 69/153 (45%), Gaps = 18/153 (11%)
Query: 56 LLSYMKKIDLDTI---------------LDESGWSPVHIASSIGSVTILEKLLNHTVEPN 100
LL K DLDT+ LD +P+H A+ V +++ LL H E
Sbjct: 488 LLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAE-- 545
Query: 101 LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
+ G+ LH ACS H V +LLV+ GA+V + D PLH AAA G I +L
Sbjct: 546 VYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLL 605
Query: 161 CDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTL 193
+ K+++G +P + E DVA L
Sbjct: 606 LKHGADPMKKNRDGATPA-DLVKESDHDVAELL 637
Score = 58.2 bits (139), Expect = 1e-08
Identities = 53/194 (27%), Positives = 85/194 (43%), Gaps = 23/194 (11%)
Query: 21 QILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTI------------ 68
++L + V D G+ PLH +Q + +LLSY ++ ++
Sbjct: 416 EVLLKQGAKVNALDSLGQTPLHRCARDEQ--AVRLLLSYAADTNIVSLEGLTAAQLASDS 473
Query: 69 ----LDESGWSPVHI--ASSIGSV-TILEKLLNHTVEPNL-DLQANNGITALHLACSKKH 120
L S H+ A+ G + T+ +LN+ + N DL + T LH A
Sbjct: 474 VLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHS-TPLHFAAGFNR 532
Query: 121 LNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFH 180
+ VVQ L+E GA V D G +PLH A + G + +L + VN+ D ++PL
Sbjct: 533 VPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHE 592
Query: 181 ALAEGHGDVAVTLV 194
A A+G D+ L+
Sbjct: 593 AAAKGKYDICKLLL 606
Score = 54.7 bits (130), Expect = 1e-07
Identities = 29/91 (31%), Positives = 50/91 (54%), Gaps = 2/91 (2%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
+P+H+A+ + I+E LL + + + + G+ LH ACS H +V +LL++ GA+V
Sbjct: 212 TPLHLAAGYNRIGIVEILLANGAD--VHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANV 269
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNS 165
D PLH AA+ V + S+L + +
Sbjct: 270 NANDLWAFTPLHEAASKSRVEVCSLLLSRGA 300
Score = 54.7 bits (130), Expect = 1e-07
Identities = 33/104 (31%), Positives = 50/104 (47%), Gaps = 2/104 (1%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
+P+H A+ G ++E LLN ++ G+ LH CS H VV+LL++ GAS
Sbjct: 59 TPLHFAAGYGRREVVEFLLNSGA--SIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASP 116
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
D PLH AA+ G V + L + I++ +PL
Sbjct: 117 NTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPL 160
Score = 52.4 bits (124), Expect = 5e-07
Identities = 35/132 (26%), Positives = 58/132 (43%), Gaps = 1/132 (0%)
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
++LD ++ + A G + ++KL+ D A T LH A
Sbjct: 13 VNLDAVMANDPLRELFEACKTGEIAKVKKLITPQTVNARDT-AGRKSTPLHFAAGYGRRE 71
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
VV+ L+ GAS++ D G PLH + G +V +L + N D ++PL A
Sbjct: 72 VVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAA 131
Query: 183 AEGHGDVAVTLV 194
++G DV + L+
Sbjct: 132 SKGKVDVCLALL 143
>7296936 [R] KOG0504 FOG: Ankyrin repeat
Length = 600
Score = 68.6 bits (166), Expect = 7e-12
Identities = 45/163 (27%), Positives = 80/163 (48%), Gaps = 6/163 (3%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL 93
D D PLH+A + + + ILL + I+ +L+ G++P+H+ + VT E L+
Sbjct: 146 DADVATPLHYAAYWGHEECVRILLEHNAPIN---VLNNDGYAPLHLGAGFAGVT--ELLI 200
Query: 94 NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGS 153
H N ++G TALH+A K +LL++ ++ D G+ PL A A
Sbjct: 201 KHGALVNAKT-LSDGKTALHMAIESKCAESARLLLQTNININDTDDDGETPLMAAIACSM 259
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
+ + L + + +NI+DK + L +A+ H +A L+ +
Sbjct: 260 LDVAEELVKRGARINIQDKQNHTALQYAVRGRHTQMAKLLLER 302
>Hs7705831 [R] KOG0504 FOG: Ankyrin repeat
Length = 518
Score = 68.2 bits (165), Expect = 9e-12
Identities = 53/182 (29%), Positives = 89/182 (48%), Gaps = 6/182 (3%)
Query: 7 LHAACMNGDTEKVQQILS--EFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID 64
+H A + E +Q +++ +K+K +G LH A S I+ ILL +
Sbjct: 47 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN 106
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
T L+E+ +P+ +A G + +L LL H N + G +LH A +++ ++
Sbjct: 107 ATT-LEET--TPLFLAVENGQIDVLRLLLQHGANVN-GSHSMCGWNSLHQASFQENAEII 162
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
+LL+ +GA+ +D G PL AA G + +SIL + VN + + +PLF A E
Sbjct: 163 KLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE 222
Query: 185 GH 186
GH
Sbjct: 223 GH 224
Score = 66.2 bits (160), Expect = 4e-11
Identities = 42/146 (28%), Positives = 69/146 (46%), Gaps = 2/146 (1%)
Query: 53 IDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN-LDLQANNGITA 111
+ +L +KK + D GW P+H A+ SV L+ L+N N + ++ G A
Sbjct: 23 VKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCA 82
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN-IK 170
LHLA S+ H +VQ+L+E GA PL A +G + ++ +L + VN
Sbjct: 83 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 142
Query: 171 DKNGWSPLFHALAEGHGDVAVTLVNK 196
GW+ L A + + ++ L+ K
Sbjct: 143 SMCGWNSLHQASFQENAEIIKLLLRK 168
Score = 53.5 bits (127), Expect = 2e-07
Identities = 52/194 (26%), Positives = 88/194 (44%), Gaps = 8/194 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L A NG + ++ +L G LH A SFQ++ +I+ ++K
Sbjct: 116 LFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQA-SFQEN--AEIIKLLLRKGANK 172
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D+ G +P+ +A+ G + L L++ N++ QA + T L +A + H V+L
Sbjct: 173 ECQDDFGITPLFVAAQYGKLESLSILISSGA--NVNCQALDKATPLFIAAQEGHTKCVEL 230
Query: 127 LVERGASVRI--KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
L+ GA + + QLP+H AA G I+ +L + N SP++ A+
Sbjct: 231 LLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFG 290
Query: 185 GHGD-VAVTLVNKY 197
GH D + + L N Y
Sbjct: 291 GHEDCLEILLRNGY 304
>Hs6601590 [R] KOG0510 Ankyrin repeat protein
Length = 1119
Score = 68.2 bits (165), Expect = 9e-12
Identities = 60/216 (27%), Positives = 100/216 (45%), Gaps = 22/216 (10%)
Query: 5 FLLHAACMNGDTEKVQQILSEFPGAVKVKDDD-GRYPLHWAVSFQQDNIIDILLSYMKKI 63
F LH A G E +++I + V + DD G PLH AV Q + LLS
Sbjct: 65 FFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANP 124
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNH-TVEPNLDLQANNGITALHLACSKKHLN 122
+L + +P+HIA + +++ LL H T++ NL+ NG TA+ +AC+ +
Sbjct: 125 NLRNF---NMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLE--GENGNTAVIIACTTNNSE 179
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
+Q+L+ +GA + G P+H+AA SGS + I+ + +++G+S H
Sbjct: 180 ALQILLNKGAKPCKSNKWGCFPIHQAAFSGSKECMEII------LRFGEEHGYSRQLHIN 233
Query: 183 AEGHGDVAVTLVNKYHALWEGETDNDDLSIDKICVD 218
+G + N DL + K+C+D
Sbjct: 234 FMNNGKATPLHL---------AVQNGDLEMIKMCLD 260
Score = 67.4 bits (163), Expect = 2e-11
Identities = 49/165 (29%), Positives = 82/165 (49%), Gaps = 6/165 (3%)
Query: 33 KDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKL 92
+D+DG PLH+A ++ LL + I + + SP+H A+S G + ++L
Sbjct: 409 EDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKS---KDKKSPLHFAASYGRINTCQRL 465
Query: 93 LNHTVEPNLDLQAN-NGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAAS 151
L + L + + +G+T LHLA H VVQLL+++GA + + D G LH A+
Sbjct: 466 LQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMG 524
Query: 152 GSVGIVSILCDKNSPVNIK-DKNGWSPLFHALAEGHGDVAVTLVN 195
G + ++ D N + D++G + L A EGH L++
Sbjct: 525 GYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLS 569
Score = 62.0 bits (149), Expect = 7e-10
Identities = 53/189 (28%), Positives = 88/189 (46%), Gaps = 6/189 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC G V +L F ++ K D + PLH+A S+ + N LL + L
Sbjct: 417 LHYACRQGGPGSVNNLLG-FNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLL 475
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D G +P+H+A+ G +++ LL + L L +NG TALH A + +++
Sbjct: 476 NEGDLHGMTPLHLAAKNGHDKVVQLLLK---KGALFLSDHNGWTALHHASMGGYTQTMKV 532
Query: 127 LVERGASVRIK-DGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+++ + D G LH AA G V++L N+ + + +K S L AL
Sbjct: 533 ILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHNK 591
Query: 186 HGDVAVTLV 194
+V +T++
Sbjct: 592 RKEVVLTII 600
Score = 57.8 bits (138), Expect = 1e-08
Identities = 57/188 (30%), Positives = 87/188 (45%), Gaps = 15/188 (7%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVK-VKDDDGRYP--LHWAVSFQQDNIIDILLSYMKKI 63
+H A G TE V+ ++S + G+V V DG + LH A F + D L+S I
Sbjct: 276 IHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADI 335
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
+ +D G SP+ +A++ S I+ LL+ + +D++ N G LHL + + +
Sbjct: 336 NK---IDSEGRSPLILATASASWNIVNLLLSKGAQ--VDIKDNFGRNFLHLTVQQPY-GL 389
Query: 124 VQLLVERGASVRIK------DGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSP 177
L E +IK D G PLH A G G V+ L N ++ K K+ SP
Sbjct: 390 KNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSP 449
Query: 178 LFHALAEG 185
L A + G
Sbjct: 450 LHFAASYG 457
Score = 53.5 bits (127), Expect = 2e-07
Identities = 45/198 (22%), Positives = 92/198 (45%), Gaps = 16/198 (8%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDD-GRYPLHWAVSFQQDNIIDILL------SYMKK 62
AC ++E +Q +L++ GA K + G +P+H A ++I+L Y ++
Sbjct: 172 ACTTNNSEALQILLNK--GAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQ 229
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
+ ++ ++ +P+H+A G + +++ L++ + +D TA+H A ++
Sbjct: 230 LHIN-FMNNGKATPLHLAVQNGDLEMIKMCLDNGAQ--IDPVEKGRCTAIHFAATQGATE 286
Query: 123 VVQLLVERGAS----VRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
+V+L++ + V DG + LHRA+ + L + +N D G SPL
Sbjct: 287 IVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPL 346
Query: 179 FHALAEGHGDVAVTLVNK 196
A A ++ L++K
Sbjct: 347 ILATASASWNIVNLLLSK 364
Score = 51.2 bits (121), Expect = 1e-06
Identities = 50/187 (26%), Positives = 86/187 (45%), Gaps = 13/187 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYP-LHWAVSFQQDNIIDILLS-YMKKID 64
LH A NGD E ++ L GA + GR +H+A + I+ +++S Y +D
Sbjct: 243 LHLAVQNGDLEMIKMCLDN--GAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD 300
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
+ D + +H AS + + L++ V +++ + G + L LA + N+V
Sbjct: 301 IVNTTDGCHETMLHRASLFDHHELADYLIS--VGADINKIDSEGRSPLILATASASWNIV 358
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK------DKNGWSPL 178
LL+ +GA V IKD G+ LH G+ ++ + IK D +G +PL
Sbjct: 359 NLLLSKGAQVDIKDNFGRNFLH-LTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPL 417
Query: 179 FHALAEG 185
+A +G
Sbjct: 418 HYACRQG 424
>Hs20543919 [R] KOG0504 FOG: Ankyrin repeat
Length = 339
Score = 68.2 bits (165), Expect = 9e-12
Identities = 55/192 (28%), Positives = 93/192 (47%), Gaps = 7/192 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A D + + +IL V V + G L A ++ IL+S ++L
Sbjct: 108 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 167
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ SG + +A G + +++ L H + + G TALH A H +V++
Sbjct: 168 ---NGSGKDSLMLACYAGHLDVVKYLRRHGA--SWQARDLGGCTALHWAADGGHCSVIEW 222
Query: 127 LVERGASVRIKD-GLGQLPLHRAAA-SGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
+++ G V + D G G PL R +A SG+ + S+L D + VN+KD+NG +PL A+
Sbjct: 223 MIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLN 282
Query: 185 GHGDVAVTLVNK 196
H ++ L++K
Sbjct: 283 NHEELVQLLLDK 294
Score = 55.1 bits (131), Expect = 8e-08
Identities = 43/160 (26%), Positives = 79/160 (48%), Gaps = 7/160 (4%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMK 61
G D L+ AC G + V+ L + + +D G LHWA ++I+ ++
Sbjct: 171 GKDSLM-LACYAGHLDVVKY-LRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK--D 226
Query: 62 KIDLDTILDESGWSPVHIASSI-GSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKH 120
++D + SGW+P+ S++ G+ + L++ N++++ NG T L +A H
Sbjct: 227 GCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLID--AGANVNVKDRNGKTPLMVAVLNNH 284
Query: 121 LNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
+VQLL+++GA +K+ G+ L A +VS+L
Sbjct: 285 EELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVVSLL 324
>Hs18426879 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1176
Score = 68.2 bits (165), Expect = 9e-12
Identities = 49/190 (25%), Positives = 96/190 (49%), Gaps = 5/190 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LHAA G E + +L + + D R PL AV +N +++ +++
Sbjct: 655 LHAAAQKGSVE-ICHVLLQAGANINAVDKQQRTPLMEAVV---NNHLEVARYMVQRGGCV 710
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+E G + +H A+ IG++ ++ LL+ T + +++ Q + G T + A KH+ V+++
Sbjct: 711 YSKEEDGSTCLHHAAKIGNLEMVSLLLS-TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRM 769
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ RGA V + D + LH A+ +GS I +L + ++ + +G +PL A E +
Sbjct: 770 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 829
Query: 187 GDVAVTLVNK 196
D + +++
Sbjct: 830 HDCVLLFLSR 839
Score = 63.2 bits (152), Expect = 3e-10
Identities = 47/160 (29%), Positives = 76/160 (47%), Gaps = 4/160 (2%)
Query: 39 YPLHWAVSFQQDNIIDILLSYMKKIDLDTILDE-SGWSPVHIASSIGSVTILEKLLNHTV 97
+P +S +Q + ++L + +D + D+ S +P+H A+ GSV I LL
Sbjct: 616 HPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQ--A 673
Query: 98 EPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIV 157
N++ T L A HL V + +V+RG V K+ G LH AA G++ +V
Sbjct: 674 GANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMV 733
Query: 158 SILCDKNS-PVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
S+L VN +D GW+P+ A H +V L+ +
Sbjct: 734 SLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Score = 53.9 bits (128), Expect = 2e-07
Identities = 44/137 (32%), Positives = 64/137 (46%), Gaps = 9/137 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+ E V +LS V +D G P+ WA + +I +LL+ +
Sbjct: 721 LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADV--- 777
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVV 124
T+ D +H AS GS I E LLN DL A N G T LH+A + + + V
Sbjct: 778 TLTDNEENICLHWASFTGSAAIAEVLLN----ARCDLHAVNYHGDTPLHIAARESYHDCV 833
Query: 125 QLLVERGASVRIKDGLG 141
L + RGA+ +++ G
Sbjct: 834 LLFLSRGANPELRNKEG 850
>Hs18375637 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1210
Score = 68.2 bits (165), Expect = 9e-12
Identities = 49/190 (25%), Positives = 96/190 (49%), Gaps = 5/190 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LHAA G E + +L + + D R PL AV +N +++ +++
Sbjct: 689 LHAAAQKGSVE-ICHVLLQAGANINAVDKQQRTPLMEAVV---NNHLEVARYMVQRGGCV 744
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+E G + +H A+ IG++ ++ LL+ T + +++ Q + G T + A KH+ V+++
Sbjct: 745 YSKEEDGSTCLHHAAKIGNLEMVSLLLS-TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRM 803
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ RGA V + D + LH A+ +GS I +L + ++ + +G +PL A E +
Sbjct: 804 LLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESY 863
Query: 187 GDVAVTLVNK 196
D + +++
Sbjct: 864 HDCVLLFLSR 873
Score = 63.2 bits (152), Expect = 3e-10
Identities = 47/160 (29%), Positives = 76/160 (47%), Gaps = 4/160 (2%)
Query: 39 YPLHWAVSFQQDNIIDILLSYMKKIDLDTILDE-SGWSPVHIASSIGSVTILEKLLNHTV 97
+P +S +Q + ++L + +D + D+ S +P+H A+ GSV I LL
Sbjct: 650 HPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQ--A 707
Query: 98 EPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIV 157
N++ T L A HL V + +V+RG V K+ G LH AA G++ +V
Sbjct: 708 GANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMV 767
Query: 158 SILCDKNS-PVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
S+L VN +D GW+P+ A H +V L+ +
Sbjct: 768 SLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Score = 53.9 bits (128), Expect = 2e-07
Identities = 44/137 (32%), Positives = 64/137 (46%), Gaps = 9/137 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+ E V +LS V +D G P+ WA + +I +LL+ +
Sbjct: 755 LHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADV--- 811
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVV 124
T+ D +H AS GS I E LLN DL A N G T LH+A + + + V
Sbjct: 812 TLTDNEENICLHWASFTGSAAIAEVLLN----ARCDLHAVNYHGDTPLHIAARESYHDCV 867
Query: 125 QLLVERGASVRIKDGLG 141
L + RGA+ +++ G
Sbjct: 868 LLFLSRGANPELRNKEG 884
>Hs18252778 [R] KOG0504 FOG: Ankyrin repeat
Length = 587
Score = 68.2 bits (165), Expect = 9e-12
Identities = 55/189 (29%), Positives = 92/189 (48%), Gaps = 7/189 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L+ AC + E V+ IL + + + G LH +VS ++ IL+S K++
Sbjct: 161 LYKACERKNAEAVK-ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK 219
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
G +P+ +A+ G + L L + + N QA++ +AL+ AC +H VV+
Sbjct: 220 NAY---GITPLFVAAQSGQLEALRFLAKYGADINT--QASDNASALYEACKNEHEEVVEF 274
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ +GA + G LPLH A+ G+ IV +L S I+ ++G SPL A H
Sbjct: 275 LLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNH 333
Query: 187 GDVAVTLVN 195
+V L++
Sbjct: 334 DEVLEALLS 342
Score = 63.2 bits (152), Expect = 3e-10
Identities = 56/219 (25%), Positives = 95/219 (42%), Gaps = 36/219 (16%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILL-SYMKKIDLDTI 68
A +GD E ++ ++ E + + +G PLH A + Q + +L +Y ID T+
Sbjct: 64 AIKDGDEEALKTMIKEGKNLAE-PNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTL 122
Query: 69 LDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQA----------------------- 105
+E+ V++A+ G + L LL EP++ ++
Sbjct: 123 QEETA---VYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
Query: 106 --------NNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIV 157
N G TALH + S+ L V+Q+LV GA V K+ G PL AA SG + +
Sbjct: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
Query: 158 SILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
L + +N + + S L+ A H +V L+++
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQ 278
Score = 48.1 bits (113), Expect = 1e-05
Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 15/169 (8%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L+ AC N E V+ +LS+ A K + DG PLH A I+ +LL +
Sbjct: 260 LYEACKNEHEEVVEFLLSQGADANKT-NKDGLLPLHIASKKGNYRIVQMLLPVTSR---- 314
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNG-------ITALHLACSKK 119
T + SG SP+H+A+ +LE LL+ + N L +AL+ A
Sbjct: 315 TRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNN 374
Query: 120 HLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN 168
++ +LL++ GA +D + PL A G + + +L D + ++
Sbjct: 375 NVYATELLLQHGADPN-RDVIS--PLLVAIRHGCLRTMQLLLDHGANID 420
>Hs14738291 [R] KOG0504 FOG: Ankyrin repeat
Length = 1554
Score = 68.2 bits (165), Expect = 9e-12
Identities = 65/210 (30%), Positives = 95/210 (44%), Gaps = 10/210 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L AA G E V ++L AV + G PL A I+ +LL ++L
Sbjct: 776 LTAAAGRGKLE-VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 834
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D+ G +P+ +A+ G ++ +E LL+ L G++AL AC K H VVQ
Sbjct: 835 ---DKQGRTPLMVAACEGHLSTVEFLLSKGAA--LSSLDKEGLSALSWACLKGHRAVVQY 889
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LVE GA++ D G+ PL AA G V L +K + + D +G PL A+ +
Sbjct: 890 LVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRN 949
Query: 187 GDVAVTLVNK----YHALWEGETDNDDLSI 212
V V L+ K +A W T D+ I
Sbjct: 950 TSVVVALLRKGAKLGNAAWAMATSKPDILI 979
Score = 65.1 bits (157), Expect = 8e-11
Identities = 52/190 (27%), Positives = 85/190 (44%), Gaps = 9/190 (4%)
Query: 44 AVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHI--ASSIGSVTILEKLLNHTVEPNL 101
A S +++ LL K+ +++ ++ W + A+ G + + E LL H +
Sbjct: 741 AASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAA--V 798
Query: 102 DLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILC 161
G+ L A + H +V+LL+ERG V + D G+ PL AA G + V L
Sbjct: 799 SRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLL 858
Query: 162 DKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDND---DLSIDKICVD 218
K + ++ DK G S L A +GH V LV + A+ +TD + L + D
Sbjct: 859 SKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI--DQTDKNGRTPLDLAAFYGD 916
Query: 219 AKVKDYFLSK 228
A+ Y + K
Sbjct: 917 AETVLYLVEK 926
>7298956 [R] KOG0510 Ankyrin repeat protein
Length = 914
Score = 67.4 bits (163), Expect = 2e-11
Identities = 54/178 (30%), Positives = 91/178 (50%), Gaps = 19/178 (10%)
Query: 41 LHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN 100
LH AV + N ++ L ++ + L +G + +H+A+ +G++ LE LLN PN
Sbjct: 183 LHCAV---RSNALECLQIFIAEGADVNSLKPNGTNAIHLAADLGNIQCLEALLN---APN 236
Query: 101 LDLQANNGI-----TALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVG 155
D I TALHLA + ++ V LL+ +GA ++K+ G PLH AA + S+
Sbjct: 237 ADANVRICIREKESTALHLAADEGNVECVDLLLAKGADAKLKNHRGFTPLHLAARTSSLD 296
Query: 156 IV-SILCDKNSPVNIKDKNGWSPLFHAL--AEGHGDVAVTLVNKYHALWEGETDNDDL 210
V S+L + N+ N +D + +PL A+ +E D+ TL+ W ++ D+
Sbjct: 297 CVESLLRNGNADANAEDFDHRTPLHAAVGKSENAYDIMETLIQ-----WGANVNHKDI 349
Score = 52.4 bits (124), Expect = 5e-07
Identities = 45/142 (31%), Positives = 68/142 (47%), Gaps = 10/142 (7%)
Query: 41 LHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN 100
LH A +D+LL+ K D + + G++P+H+A+ S+ +E LL + N
Sbjct: 253 LHLAADEGNVECVDLLLA--KGADAK-LKNHRGFTPLHLAARTSSLDCVESLLRNG---N 306
Query: 101 LDLQANN--GITALHLACSKKH--LNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGI 156
D A + T LH A K ++++ L++ GA+V KD G LH AA G V
Sbjct: 307 ADANAEDFDHRTPLHAAVGKSENAYDIMETLIQWGANVNHKDIYGFTALHLAALDGLVQC 366
Query: 157 VSILCDKNSPVNIKDKNGWSPL 178
V +L + V K K G S L
Sbjct: 367 VEMLIFHGADVTTKSKKGTSAL 388
>Hs13386462 [R] KOG0504 FOG: Ankyrin repeat
Length = 435
Score = 67.0 bits (162), Expect = 2e-11
Identities = 60/217 (27%), Positives = 110/217 (50%), Gaps = 7/217 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L AC +GD V+++L E +V ++G L A S + +LL+ +++
Sbjct: 17 LAEACSDGDVNAVRKLLDE-GRSVNEHTEEGESLLCLACSAGYYELAQVLLA--MHANVE 73
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++ +P+ ASS G + I++ LL H + N Q+ G TAL AC+ +++V++
Sbjct: 74 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVN--SQSATGNTALTYACAGGFVDIVKV 131
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNI-KDKNGWSPLFHALAEG 185
L+ GA++ + G PL AA++G V + +L D + +N ++ S L A +G
Sbjct: 132 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 191
Query: 186 HGDVAVTLVNKYHALWEGETDNDDLSIDKICVDAKVK 222
H D+ V + + A E +TD ++ + C+D V+
Sbjct: 192 HLDM-VRFLLEAGADQEHKTDEMHTALMEACMDGHVE 227
Score = 60.1 bits (144), Expect = 3e-09
Identities = 52/187 (27%), Positives = 85/187 (44%), Gaps = 4/187 (2%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
A +G + ++L V + G L +A + +I+ +LL+ I+
Sbjct: 86 AASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH--- 142
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
+E+G +P+ A+S G V + LL+H N +AL LAC K HL++V+ L+E
Sbjct: 143 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE-SALTLACYKGHLDMVRFLLE 201
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
GA K L A G V + +L D + VN+ + SPL A GH ++
Sbjct: 202 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 261
Query: 190 AVTLVNK 196
A L+ +
Sbjct: 262 AALLIER 268
Score = 59.3 bits (142), Expect = 4e-09
Identities = 50/186 (26%), Positives = 92/186 (48%), Gaps = 7/186 (3%)
Query: 10 ACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTI 68
AC G + V+ +L+E GA ++ +++G PL A S + +LL + I+ T
Sbjct: 120 ACAGGFVDIVKVLLNE--GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN--TH 175
Query: 69 LDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV 128
+E S + +A G + ++ LL + + + + TAL AC H+ V +LL+
Sbjct: 176 SNEFKESALTLACYKGHLDMVRFLLEAGADQ--EHKTDEMHTALMEACMDGHVEVARLLL 233
Query: 129 ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGD 188
+ GA V + + PL AA G V + ++L ++ + + + G++PL A EGH +
Sbjct: 234 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEE 293
Query: 189 VAVTLV 194
+ L+
Sbjct: 294 MVALLL 299
Score = 49.7 bits (117), Expect = 3e-06
Identities = 50/188 (26%), Positives = 81/188 (42%), Gaps = 8/188 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L ACM+G E V ++L + V + D PL A + +L+ + +L+
Sbjct: 217 LMEACMDGHVE-VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE--RGANLE 273
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ DE G++P+ A+ G ++ LL N + TAL LAC V
Sbjct: 274 EVNDE-GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE-TALTLACCGGFSEVADF 331
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L++ GA + + PL A+ G + +V L + V+ G + L +A GH
Sbjct: 332 LIKAGADIELGCST---PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 388
Query: 187 GDVAVTLV 194
DVA L+
Sbjct: 389 TDVADVLL 396
>7295200_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 458
Score = 67.0 bits (162), Expect = 2e-11
Identities = 39/96 (40%), Positives = 54/96 (55%), Gaps = 5/96 (5%)
Query: 106 NNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNS 165
N G T LH AC +L +V+ L+++G +V ++D G LPLH A G IV +L DK +
Sbjct: 10 NKGETQLHQACISGNLELVRRLIDQGHTVNVRDHAGWLPLHEACNHGYREIVELLLDKGA 69
Query: 166 PVNIKDKNGWS-----PLFHALAEGHGDVAVTLVNK 196
I DK G S PLF A + G DVA L+++
Sbjct: 70 ASAINDKGGTSCDGITPLFDACSNGFLDVAELLLDR 105
>Hs20556512 [T] KOG0507 CASK-interacting adaptor protein (caskin) and related
proteins with ankyrin repeats and SAM domain
Length = 765
Score = 66.2 bits (160), Expect = 4e-11
Identities = 52/195 (26%), Positives = 86/195 (43%), Gaps = 29/195 (14%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKV-----------------------KDDDGRYPLHW 43
LH A GD + V+ ++ + P +V K++D LH
Sbjct: 190 LHLAAWKGDAQIVRLLIHQGPSHTRVNEQNALEIKELKKYGPFDPYINAKNNDNETALHC 249
Query: 44 AVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDL 103
A + ++ +LL +++ T+ + +P+ +A+ G + +++ LLN PNL
Sbjct: 250 AAQYGHTEVVKVLL---EELTDPTMRNNKFETPLDLAALYGRLEVVKMLLN--AHPNLLS 304
Query: 104 QANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDK 163
T LHLA H VVQ+L++ G + +G LH AA G +V IL
Sbjct: 305 CNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAA 363
Query: 164 NSPVNIKDKNGWSPL 178
+ VNIKD +G + L
Sbjct: 364 GTDVNIKDNHGLTAL 378
Score = 55.5 bits (132), Expect = 6e-08
Identities = 46/188 (24%), Positives = 81/188 (42%), Gaps = 25/188 (13%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
V D G PLH A +++++LL + L + D G P+H+A+ G I+
Sbjct: 146 VNCVDSTGYTPLHHAALNGHKDVVEVLL---RNDALTNVADSKGCYPLHLAAWKGDAQIV 202
Query: 90 EKLLN----HT------------------VEPNLDLQANNGITALHLACSKKHLNVVQLL 127
L++ HT +P ++ + N+ TALH A H VV++L
Sbjct: 203 RLLIHQGPSHTRVNEQNALEIKELKKYGPFDPYINAKNNDNETALHCAAQYGHTEVVKVL 262
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHG 187
+E +++ + PL AA G + +V +L + + + + +PL A GH
Sbjct: 263 LEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHK 322
Query: 188 DVAVTLVN 195
V L++
Sbjct: 323 AVVQVLLD 330
>At1g05640 [R] KOG0504 FOG: Ankyrin repeat
Length = 627
Score = 66.2 bits (160), Expect = 4e-11
Identities = 65/235 (27%), Positives = 101/235 (42%), Gaps = 46/235 (19%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGAVKVKDD------DGRYPLHWAVSFQQDNIIDILL 57
D LH A G+ KV +++ G ++K+ +G PL+ A +++ +L
Sbjct: 114 DSPLHLAARTGNLGKVMELIRACNGIEELKELSSKQNLEGETPLYSAAENGHSLVVEEML 173
Query: 58 SYMKKIDLDT--ILDESGWSPVHIASSIGSVTILEKLLN--------------------- 94
+M DLDT + +G+ P H+A+ G + L+KLL
Sbjct: 174 KHM---DLDTASVKARNGFDPFHVAAKQGHIEALKKLLETFPNLAMTVDLSCTTALHTAA 230
Query: 95 ---HTVEPNLDLQA---------NNGITALHLACSKKHLNVVQLLVERGASVRIK-DGLG 141
HT NL L+ NNG TALH A H VV+ L+ AS+ + D G
Sbjct: 231 SQGHTDVVNLLLKTDSHLAKIAKNNGKTALHSAARMGHREVVKSLIGNDASIGFRTDKKG 290
Query: 142 QLPLHRAAASGSVGIVSILCDKNSPV-NIKDKNGWSPLFHALAEGHGDVAVTLVN 195
Q LH A + GIV L + + +++D G +PL A +G + LV+
Sbjct: 291 QTALHMAVKGQNEGIVLELVKPDPAILSVEDSKGNTPLHTATNKGRIKIVRCLVS 345
>7298524_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 611
Score = 65.9 bits (159), Expect = 5e-11
Identities = 59/201 (29%), Positives = 94/201 (46%), Gaps = 10/201 (4%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
G + A G + V ++S+ GA V D +G LH+A Q + +LL +
Sbjct: 25 GGKACIQVASHQGYVDLVSYLISK--GANVNAVDKEGDSALHYAAFGNQPATMRVLLQHG 82
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKH 120
+++ L+ S S +HI + + + +LL H N+++Q + G TALH A K++
Sbjct: 83 AEVNF---LNSSHCSALHICAHKKTPHCVRELLQHNA--NVNIQDSYGDTALHDAIGKEN 137
Query: 121 LNVVQLLVER-GASVRIKDGLGQLPLHRAAASGSVGIVS-ILCDKNSPVNIKDKNGWSPL 178
VV+LL +K+ G LH AA G+V IL VN++ +G++ L
Sbjct: 138 TEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSRQLVNVRKDDGFAAL 197
Query: 179 FHALAEGHGDVAVTLVNKYHA 199
A GH V TLV + A
Sbjct: 198 HLAALNGHAQVVETLVTEGQA 218
Score = 59.7 bits (143), Expect = 3e-09
Identities = 43/165 (26%), Positives = 83/165 (50%), Gaps = 4/165 (2%)
Query: 11 CMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILD 70
C + T + L + V ++D G LH A+ + ++++L + +D T+ +
Sbjct: 99 CAHKKTPHCVRELLQHNANVNIQDSYGDTALHDAIGKENTEVVELLCN-APNLDF-TVKN 156
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
G++ +H A+ G+V ++L + + ++++ ++G ALHLA H VV+ LV
Sbjct: 157 NRGFNVLHHAALKGNVVAARRILLLSRQL-VNVRKDDGFAALHLAALNGHAQVVETLVTE 215
Query: 131 G-ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
G A + I++ Q P A + G G++ L + VN KD++G
Sbjct: 216 GQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLSCDVNAKDEDG 260
Score = 57.4 bits (137), Expect = 2e-08
Identities = 46/174 (26%), Positives = 81/174 (46%), Gaps = 7/174 (4%)
Query: 14 GDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESG 73
G + V+Q L P V V G+ + A +++ L+S ++ +D+ G
Sbjct: 4 GHLDFVRQYLDVNPSQVDVMSG-GKACIQVASHQGYVDLVSYLISKGANVNA---VDKEG 59
Query: 74 WSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGAS 133
S +H A+ + LL H E N ++ +ALH+ KK + V+ L++ A+
Sbjct: 60 DSALHYAAFGNQPATMRVLLQHGAEVNF--LNSSHCSALHICAHKKTPHCVRELLQHNAN 117
Query: 134 VRIKDGLGQLPLHRAAASGSVGIVSILCD-KNSPVNIKDKNGWSPLFHALAEGH 186
V I+D G LH A + +V +LC+ N +K+ G++ L HA +G+
Sbjct: 118 VNIQDSYGDTALHDAIGKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGN 171
>CE05333 [R] KOG0510 Ankyrin repeat protein
Length = 1188
Score = 65.5 bits (158), Expect = 6e-11
Identities = 55/200 (27%), Positives = 90/200 (44%), Gaps = 26/200 (13%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
++H + G+ +Q+ L + P AV +D D PLH+A + + + +LLS K L
Sbjct: 35 IIHQSAREGNVNALQEALLKAPLAVNAQDGDFMTPLHYAARYGNYDAVKLLLS---KNAL 91
Query: 66 DTILDESGWSPVHIA-------SSIGSV-------------TILEKLLNHTVEPNLDLQA 105
+ G +P+HIA S I S+ T +K++N V N ++
Sbjct: 92 PNTKNREGDTPLHIASKYIYGYSDICSIIDEDQADSARKYNTATKKIINALVSENAEIDP 151
Query: 106 NN--GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDK 163
N +T LH A K + + + L++ A V +D PL A GS I+ L
Sbjct: 152 VNKYQLTPLHYAAMKSNFSALHALIKLKADVDAEDDNKMTPLLLACVHGSQEIIQELIKA 211
Query: 164 NSPVNIKDKNGWSPLFHALA 183
NS V +D+ + +FH +A
Sbjct: 212 NSNVTKRDQR-LNTVFHIVA 230
>7296976 [M] KOG4177 Ankyrin
Length = 599
Score = 65.5 bits (158), Expect = 6e-11
Identities = 48/192 (25%), Positives = 90/192 (46%), Gaps = 7/192 (3%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI 63
D LH A D + V+ IL ++ V ++ +G+ PLH A + + LL Y +
Sbjct: 10 DTALHLAARRRDVDMVR-ILVDYGTNVDTQNGEGQTPLHIAAAEGDE----ALLKYFYGV 64
Query: 64 DLD-TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
+I D +P+H+A+ G ++E +L + ++ + +G T +H+A H
Sbjct: 65 RASASIADNQDRTPMHLAAENGHAHVIE-ILADKFKASIFERTKDGSTLMHIASLNGHAE 123
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
+L ++G + + + G +H AAA G GI++ L K V++ + ++ L A+
Sbjct: 124 CATMLFKKGVYLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAV 183
Query: 183 AEGHGDVAVTLV 194
V TL+
Sbjct: 184 ESAKPAVVETLL 195
Score = 63.9 bits (154), Expect = 2e-10
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 1/105 (0%)
Query: 107 NGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSP 166
NG TALHLA ++ +++V++LV+ G +V ++G GQ PLH AAA G ++ +
Sbjct: 8 NGDTALHLAARRRDVDMVRILVDYGTNVDTQNGEGQTPLHIAAAEGDEALLKYFYGVRAS 67
Query: 167 VNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHA-LWEGETDNDDL 210
+I D +P+ A GH V L +K+ A ++E D L
Sbjct: 68 ASIADNQDRTPMHLAAENGHAHVIEILADKFKASIFERTKDGSTL 112
Score = 63.5 bits (153), Expect = 2e-10
Identities = 57/187 (30%), Positives = 87/187 (46%), Gaps = 6/187 (3%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
AC G E V +L+ V V D +GR LH A ++ D LL+ I+ + +
Sbjct: 408 ACHRGHMELVNNLLANH-ARVDVFDTEGRSALHLAAERGYLHVCDALLTNKAFINSKSRV 466
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
G + +H+A+ G T L K L +D+ T LHLA + + V QLL+E
Sbjct: 467 ---GRTALHLAAMNG-FTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLE 522
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKN-SPVNIKDKNGWSPLFHALAEGHGD 188
GA++ D LGQ P+H AA + + + ++ S VN K+G + A +G
Sbjct: 523 LGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTCAHIAAMQGSVK 582
Query: 189 VAVTLVN 195
V L+N
Sbjct: 583 VIEELMN 589
Score = 59.3 bits (142), Expect = 4e-09
Identities = 48/199 (24%), Positives = 96/199 (48%), Gaps = 11/199 (5%)
Query: 8 HAACMNGDTEKVQQILS-----EFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKK 62
H + G+ + + +++S + A+ + G PL A +++ LL+ +
Sbjct: 367 HYCAVAGNNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHAR 426
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
+D + D G S +H+A+ G + + + LL T + ++ ++ G TALHLA +
Sbjct: 427 VD---VFDTEGRSALHLAAERGYLHVCDALL--TNKAFINSKSRVGRTALHLAAMNGFTH 481
Query: 123 VVQLLV-ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
+V+ L+ + A + I Q PLH AAASG + + +L + + ++ D G P+ A
Sbjct: 482 LVKFLIKDHNAVIDILTLRKQTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVA 541
Query: 182 LAEGHGDVAVTLVNKYHAL 200
+ +VA + ++ +L
Sbjct: 542 AQNNYSEVAKLFLQQHPSL 560
Score = 53.5 bits (127), Expect = 2e-07
Identities = 51/194 (26%), Positives = 87/194 (44%), Gaps = 14/194 (7%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
L+H A +NG E + + + + + DG +H A ++ II+ LL +K+D+
Sbjct: 112 LMHIASLNGHAECATMLFKKGV-YLHMPNKDGARSIHTAAAYGHTGIINTLLQKGEKVDV 170
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI---TALHLACSKKHLN 122
T ++ +HIA ++E LL D+ G T LH+A K +
Sbjct: 171 TT---NDNYTALHIAVESAKPAVVETLLGF----GADVHVRGGKLRETPLHIAARVKDGD 223
Query: 123 VVQL-LVERGASVRIKDGLGQLPLHRAAASGSVG-IVSILCDKNSPVNIKDKNGWSPLFH 180
L L++ GAS + P+H AA G++ ++ +L D+ P+ K G +PL
Sbjct: 224 RCALMLLKSGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPL-YKSNTGETPLHM 282
Query: 181 ALAEGHGDVAVTLV 194
A H D+ L+
Sbjct: 283 ACRACHPDIVRHLI 296
Score = 50.4 bits (119), Expect = 2e-06
Identities = 51/205 (24%), Positives = 83/205 (39%), Gaps = 12/205 (5%)
Query: 7 LHAACMNGDTEKVQQILSEFPG---AVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI 63
LH A GD + +L F G + + D+ R P+H A ++I+IL K
Sbjct: 46 LHIAAAEGD----EALLKYFYGVRASASIADNQDRTPMHLAAENGHAHVIEILADKFKAS 101
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
+ D G + +HIAS G L V L + +G ++H A + H +
Sbjct: 102 IFERTKD--GSTLMHIASLNGHAECATMLFKKGVY--LHMPNKDGARSIHTAAAYGHTGI 157
Query: 124 VQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK-DKNGWSPLFHAL 182
+ L+++G V + LH A S +V L + V+++ K +PL A
Sbjct: 158 INTLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETLLGFGADVHVRGGKLRETPLHIAA 217
Query: 183 AEGHGDVAVTLVNKYHALWEGETDN 207
GD ++ K A TD+
Sbjct: 218 RVKDGDRCALMLLKSGASPNLTTDD 242
Score = 48.5 bits (114), Expect = 8e-06
Identities = 40/180 (22%), Positives = 81/180 (44%), Gaps = 15/180 (8%)
Query: 34 DDDGRYPLHWAVSFQQDN---------IIDILLSYMKKIDLDTILDESGWSPVHIASSIG 84
++DG LH+ ++ I+ +LL + L T + + H + G
Sbjct: 316 NEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQT--KTALETAFHYCAVAG 373
Query: 85 SVTILEKLLNHT----VEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGL 140
+ +L ++++H ++ ++ Q++ G T L +AC + H+ +V L+ A V + D
Sbjct: 374 NNDVLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTE 433
Query: 141 GQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHAL 200
G+ LH AA G + + L + +N K + G + L A G + L+ ++A+
Sbjct: 434 GRSALHLAAERGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAV 493
>Hs14744423 [R] KOG0504 FOG: Ankyrin repeat
Length = 333
Score = 65.1 bits (157), Expect = 8e-11
Identities = 41/113 (36%), Positives = 58/113 (51%), Gaps = 2/113 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D+ + +H AS G + ILEKLL++ +D Q TA+H AC HL VV+LL
Sbjct: 151 DQFRRTALHRASLEGHMEILEKLLDNGA--TVDFQDRLDCTAMHWACRGGHLEVVKLLQS 208
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
GA ++D L PLH A +G V IV +N +D+ G + L A+
Sbjct: 209 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAV 261
>Hs13540484 [R] KOG0504 FOG: Ankyrin repeat
Length = 333
Score = 65.1 bits (157), Expect = 8e-11
Identities = 41/113 (36%), Positives = 58/113 (51%), Gaps = 2/113 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D+ + +H AS G + ILEKLL++ +D Q TA+H AC HL VV+LL
Sbjct: 151 DQFRRTALHRASLEGHMEILEKLLDNGA--TVDFQDRLDCTAMHWACRGGHLEVVKLLQS 208
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
GA ++D L PLH A +G V IV +N +D+ G + L A+
Sbjct: 209 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAV 261
>CE05814 [R] KOG0502 Integral membrane ankyrin-repeat protein Kidins220
(protein kinase D substrate)
Length = 1398
Score = 65.1 bits (157), Expect = 8e-11
Identities = 46/167 (27%), Positives = 81/167 (47%), Gaps = 5/167 (2%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
V D G L WA ++ +LL+ ++D + + + +A+ + ++
Sbjct: 153 VNACDKFGSTALIWAARKGHLPVVQLLLNSGAEVDAVGMYSSTA---LMLATRGNFIQVV 209
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAA 149
E LL T EPN+++ NG+TAL +A + ++ + L+ GA V D G L A
Sbjct: 210 ELLL--TREPNVNVADQNGLTALGMAARDGYADICESLINSGAFVNQCDRFGNWILTSAV 267
Query: 150 ASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
SG+ IV ++ DK + +N +D +PL A+ + D+A L+ K
Sbjct: 268 RSGNAAIVRMILDKFADINCQDSEKRTPLHLAIDKSFNDIAYILLEK 314
Score = 53.1 bits (126), Expect = 3e-07
Identities = 40/133 (30%), Positives = 70/133 (52%), Gaps = 5/133 (3%)
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN-LDLQANNGITALHLACSKKHLN 122
++ + + +G S + +A G+ + ++L ++P+ +D N G +AL A H++
Sbjct: 53 EISALRNANGESLLTVAVRSGNTAVAKQLAQ--LDPDAIDETDNEGWSALLNAAHCGHVD 110
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
+V+LL++ GASV D +G PL A + +V +L N+ VN DK G + L A
Sbjct: 111 IVRLLIDNGASVDQPDLMGWSPLMWAVYKNHLDVVDLLV--NAKVNACDKFGSTALIWAA 168
Query: 183 AEGHGDVAVTLVN 195
+GH V L+N
Sbjct: 169 RKGHLPVVQLLLN 181
>Hs17864094 [R] KOG0508 Ankyrin repeat protein
Length = 617
Score = 64.7 bits (156), Expect = 1e-10
Identities = 56/199 (28%), Positives = 94/199 (47%), Gaps = 21/199 (10%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGAVKVKDD--------DGRYPLHWAVSFQQDNII 53
GA LL AA G + V+ +L + +++V +G PL A + ++
Sbjct: 41 GATPLLMAA-RYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV 99
Query: 54 DILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALH 113
LL++ ++ T+ + + P+ A G + I++ L+ H + L++ +G T L
Sbjct: 100 QSLLNHGASVNNTTLTNST---PLRAACFDGHLEIVKYLVEHKAD--LEVSNRHGHTCLM 154
Query: 114 LACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL---CDKNSPVNIK 170
++C K H + Q L+E+GA V K G LH A SGS+ I+ +L C K K
Sbjct: 155 ISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME----K 210
Query: 171 DKNGWSPLFHALAEGHGDV 189
D G +PL A GH ++
Sbjct: 211 DGYGMTPLLSASVTGHTNI 229
Score = 53.9 bits (128), Expect = 2e-07
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 9/150 (6%)
Query: 56 LLSYMKKIDLDTILDE--SGWSPVHIASSIGSVTILEKLLNH---TVEP----NLDLQAN 106
LL+ K ++ +++ E +G +P+ +A+ G + ++E LL ++E N D +
Sbjct: 22 LLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETI 81
Query: 107 NGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSP 166
G L A + HL VVQ L+ GASV PL A G + IV L + +
Sbjct: 82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKAD 141
Query: 167 VNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
+ + +++G + L + +GH ++A L+ K
Sbjct: 142 LEVSNRHGHTCLMISCYKGHKEIAQYLLEK 171
Score = 53.9 bits (128), Expect = 2e-07
Identities = 49/187 (26%), Positives = 77/187 (40%), Gaps = 22/187 (11%)
Query: 17 EKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMK---------KIDLDT 67
E+V ++SE +G PL A + ++++ LL D +T
Sbjct: 29 EEVSSLISE--------KTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGET 80
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
I G P+ AS+ G + +++ LLNH N N+ T L AC HL +V+ L
Sbjct: 81 I---EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNS--TPLRAACFDGHLEIVKYL 135
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHG 187
VE A + + + G L + G I L +K + VN K G + L G
Sbjct: 136 VEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSL 195
Query: 188 DVAVTLV 194
D+ L+
Sbjct: 196 DIMKMLL 202
>Hs14770818 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 567
Score = 64.3 bits (155), Expect = 1e-10
Identities = 63/251 (25%), Positives = 106/251 (42%), Gaps = 41/251 (16%)
Query: 3 ADFLLHAACMNGDTEKVQQILSEFPGAVKVKDD----DGRYPLHWAVSFQQDNIIDILLS 58
A L A + D E+V+ L KV D DG LH + I+ +LLS
Sbjct: 68 ASVALLEASLRNDAEEVRYFLKN-----KVSPDLCNEDGLTALHQCCIDNFEEIVKLLLS 122
Query: 59 YMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTV------------------EPN 100
+ ++ D W+P+H A++ G + +++ L+ + EP
Sbjct: 123 HGANVNAK---DNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPT 179
Query: 101 LDL----QANNGITA-----LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAAS 151
LD+ A GIT + +A ++ + + ++ G + D G LH A A+
Sbjct: 180 LDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGAN 239
Query: 152 GSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLS 211
G + +L D V++KD +GW PL A G +A LV+ + A T D++
Sbjct: 240 GYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVS-HGASLSARTSMDEMP 298
Query: 212 IDKICVDAKVK 222
ID +C + + K
Sbjct: 299 ID-LCEEEEFK 308
>CE23926 [T] KOG4369 RTK signaling protein MASK/UNC-44
Length = 2584
Score = 64.3 bits (155), Expect = 1e-10
Identities = 53/161 (32%), Positives = 84/161 (51%), Gaps = 10/161 (6%)
Query: 40 PLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL-NHT-V 97
PL A + +I+++LL I+ D+ G+SP+ IA++ G +++E LL NH +
Sbjct: 1224 PLTIACANGHKDIVELLLKEGANIEHR---DKKGFSPLIIAATAGHSSVVEVLLKNHAAI 1280
Query: 98 EPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIV 157
E D + TAL LACS +VV+LL+ GA+ ++ PL A++ G + IV
Sbjct: 1281 EAQSDRTKD---TALSLACSGGRKDVVELLLAHGANKEHRNVSDYTPLSLASSGGYIEIV 1337
Query: 158 SILCDKNSPVNIK--DKNGWSPLFHALAEGHGDVAVTLVNK 196
++L S +N + K G SPL A GH + L+ K
Sbjct: 1338 NMLLTAGSEINSRTGSKLGISPLMLASMNGHREATRVLLEK 1378
Score = 55.8 bits (133), Expect = 5e-08
Identities = 56/221 (25%), Positives = 95/221 (42%), Gaps = 35/221 (15%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
L AC NG + V+ +L E GA ++ +D G PL A + +++++LL I+
Sbjct: 1225 LTIACANGHKDIVELLLKE--GANIEHRDKKGFSPLIIAATAGHSSVVEVLLKNHAAIEA 1282
Query: 66 ------DTIL-------------------------DESGWSPVHIASSIGSVTILEKLLN 94
DT L + S ++P+ +ASS G + I+ LL
Sbjct: 1283 QSDRTKDTALSLACSGGRKDVVELLLAHGANKEHRNVSDYTPLSLASSGGYIEIVNMLLT 1342
Query: 95 HTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIK-DGLGQLPLHRAAASGS 153
E N + GI+ L LA H ++L+E+G+ + + + L A+ G
Sbjct: 1343 AGSEINSRTGSKLGISPLMLASMNGHREATRVLLEKGSDINAQIETNRNTALTLASFQGR 1402
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
+V +L N+ V + K G +PL + G+ DV L+
Sbjct: 1403 TEVVKLLLAYNANVEHRAKTGLTPLMECASGGYVDVGNLLI 1443
Score = 52.0 bits (123), Expect = 7e-07
Identities = 45/190 (23%), Positives = 84/190 (43%), Gaps = 5/190 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQ-QDNIIDILLSYMKKIDL 65
L A MNG E + +L E + + + R SFQ + ++ +LL+Y ++
Sbjct: 1360 LMLASMNGHREATR-VLLEKGSDINAQIETNRNTALTLASFQGRTEVVKLLLAYNANVEH 1418
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
++G +P+ +S G V + L+ + N TAL ++ K H V+
Sbjct: 1419 RA---KTGLTPLMECASGGYVDVGNLLIAAGADTNASPVQQTKDTALTISAEKGHEKFVR 1475
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+L+ A+V +++ G L A G + L +K + ++ D SP+ A +G
Sbjct: 1476 MLLNGDAAVDVRNKKGCTALWLACNGGYLSTAQALLEKGADPDMFDNRKISPMMAAFRKG 1535
Query: 186 HGDVAVTLVN 195
H ++ +VN
Sbjct: 1536 HVEIVKYMVN 1545
>CE06305 [T] KOG4369 RTK signaling protein MASK/UNC-44
Length = 2606
Score = 64.3 bits (155), Expect = 1e-10
Identities = 53/161 (32%), Positives = 84/161 (51%), Gaps = 10/161 (6%)
Query: 40 PLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL-NHT-V 97
PL A + +I+++LL I+ D+ G+SP+ IA++ G +++E LL NH +
Sbjct: 1224 PLTIACANGHKDIVELLLKEGANIEHR---DKKGFSPLIIAATAGHSSVVEVLLKNHAAI 1280
Query: 98 EPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIV 157
E D + TAL LACS +VV+LL+ GA+ ++ PL A++ G + IV
Sbjct: 1281 EAQSDRTKD---TALSLACSGGRKDVVELLLAHGANKEHRNVSDYTPLSLASSGGYIEIV 1337
Query: 158 SILCDKNSPVNIK--DKNGWSPLFHALAEGHGDVAVTLVNK 196
++L S +N + K G SPL A GH + L+ K
Sbjct: 1338 NMLLTAGSEINSRTGSKLGISPLMLASMNGHREATRVLLEK 1378
Score = 55.8 bits (133), Expect = 5e-08
Identities = 56/221 (25%), Positives = 95/221 (42%), Gaps = 35/221 (15%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
L AC NG + V+ +L E GA ++ +D G PL A + +++++LL I+
Sbjct: 1225 LTIACANGHKDIVELLLKE--GANIEHRDKKGFSPLIIAATAGHSSVVEVLLKNHAAIEA 1282
Query: 66 ------DTIL-------------------------DESGWSPVHIASSIGSVTILEKLLN 94
DT L + S ++P+ +ASS G + I+ LL
Sbjct: 1283 QSDRTKDTALSLACSGGRKDVVELLLAHGANKEHRNVSDYTPLSLASSGGYIEIVNMLLT 1342
Query: 95 HTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIK-DGLGQLPLHRAAASGS 153
E N + GI+ L LA H ++L+E+G+ + + + L A+ G
Sbjct: 1343 AGSEINSRTGSKLGISPLMLASMNGHREATRVLLEKGSDINAQIETNRNTALTLASFQGR 1402
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
+V +L N+ V + K G +PL + G+ DV L+
Sbjct: 1403 TEVVKLLLAYNANVEHRAKTGLTPLMECASGGYVDVGNLLI 1443
Score = 52.0 bits (123), Expect = 7e-07
Identities = 45/190 (23%), Positives = 84/190 (43%), Gaps = 5/190 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQ-QDNIIDILLSYMKKIDL 65
L A MNG E + +L E + + + R SFQ + ++ +LL+Y ++
Sbjct: 1360 LMLASMNGHREATR-VLLEKGSDINAQIETNRNTALTLASFQGRTEVVKLLLAYNANVEH 1418
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
++G +P+ +S G V + L+ + N TAL ++ K H V+
Sbjct: 1419 RA---KTGLTPLMECASGGYVDVGNLLIAAGADTNASPVQQTKDTALTISAEKGHEKFVR 1475
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+L+ A+V +++ G L A G + L +K + ++ D SP+ A +G
Sbjct: 1476 MLLNGDAAVDVRNKKGCTALWLACNGGYLSTAQALLEKGADPDMFDNRKISPMMAAFRKG 1535
Query: 186 HGDVAVTLVN 195
H ++ +VN
Sbjct: 1536 HVEIVKYMVN 1545
>7291279 [R] KOG0502 Integral membrane ankyrin-repeat protein Kidins220
(protein kinase D substrate)
Length = 1498
Score = 64.3 bits (155), Expect = 1e-10
Identities = 53/214 (24%), Positives = 99/214 (45%), Gaps = 15/214 (7%)
Query: 19 VQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVH 78
+ ++L + V V D G L WA I+D LL +D + W+P+
Sbjct: 175 IVELLVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAGANVDTAGMYS---WTPLL 231
Query: 79 IASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKD 138
+A++ G + +L +PN++ +G+TAL +A + ++ L+ GA + I+D
Sbjct: 232 VAAAGGHTDCVSSILEK--KPNVNALDKDGMTALCIASREGFQDIAASLIAAGAYINIQD 289
Query: 139 GLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV---- 194
PL A +G +V L K++ V+I+ K+ + ++ A+ +GH + L+
Sbjct: 290 RGADTPLIHAVKAGHRTVVEALLKKHADVDIQGKDRKTAIYTAVEKGHTPIVKLLLATNP 349
Query: 195 NKYHALWEGETD------NDDLSIDKICVDAKVK 222
+ A +G+T N +L I + +D K K
Sbjct: 350 DLESATKDGDTPLLRAVRNRNLEIVHLLLDRKAK 383
Score = 60.5 bits (145), Expect = 2e-09
Identities = 41/146 (28%), Positives = 71/146 (48%), Gaps = 5/146 (3%)
Query: 51 NIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGIT 110
+++ +LL + +++ D GW+ + A+ G ++ LL+ + N N +
Sbjct: 108 DVVQLLLDHGAEVEHR---DMGGWTSLMWAAYRGHTELVRLLLDKGADGNA--HGNYHLG 162
Query: 111 ALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK 170
AL A + + ++V+LLV+RGA V + D G L A G+V IV L + V+
Sbjct: 163 ALLWAAGRGYKDIVELLVQRGAKVNVGDKYGTTALVWACRRGNVEIVDTLLKAGANVDTA 222
Query: 171 DKNGWSPLFHALAEGHGDVAVTLVNK 196
W+PL A A GH D +++ K
Sbjct: 223 GMYSWTPLLVAAAGGHTDCVSSILEK 248
Score = 59.3 bits (142), Expect = 4e-09
Identities = 56/193 (29%), Positives = 85/193 (44%), Gaps = 16/193 (8%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L A NG + VQ +L + V+ +D G L WA ++ +LL D
Sbjct: 98 LLCASRNGHLDVVQLLL-DHGAEVEHRDMGGWTSLMWAAYRGHTELVRLLL--------D 148
Query: 67 TILDESGWSPVHI-----ASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHL 121
D + H+ A+ G I+E L+ + N+ G TAL AC + ++
Sbjct: 149 KGADGNAHGNYHLGALLWAAGRGYKDIVELLVQRGAKVNVG--DKYGTTALVWACRRGNV 206
Query: 122 NVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
+V L++ GA+V PL AAA G VS + +K VN DK+G + L A
Sbjct: 207 EIVDTLLKAGANVDTAGMYSWTPLLVAAAGGHTDCVSSILEKKPNVNALDKDGMTALCIA 266
Query: 182 LAEGHGDVAVTLV 194
EG D+A +L+
Sbjct: 267 SREGFQDIAASLI 279
Score = 57.4 bits (137), Expect = 2e-08
Identities = 56/194 (28%), Positives = 84/194 (42%), Gaps = 7/194 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L A G T+ V IL + P V D DG L A ++ DI S +
Sbjct: 230 LLVAAAGGHTDCVSSILEKKPN-VNALDKDGMTALCIA---SREGFQDIAASLIAAGAYI 285
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
I D +P+ A G T++E LL + +D+Q + TA++ A K H +V+L
Sbjct: 286 NIQDRGADTPLIHAVKAGHRTVVEALLKKHAD--VDIQGKDRKTAIYTAVEKGHTPIVKL 343
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL-AEG 185
L+ + G PL RA + ++ IV +L D+ + V DK G + L A+ A
Sbjct: 344 LLATNPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKAKVTASDKRGDTCLHIAMRARS 403
Query: 186 HGDVAVTLVNKYHA 199
V L N H+
Sbjct: 404 KTIVEALLRNPKHS 417
>Hs21314722 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1267
Score = 63.9 bits (154), Expect = 2e-10
Identities = 51/190 (26%), Positives = 95/190 (49%), Gaps = 5/190 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LHAA G + + +L + + +D R PL A ++N ++ + +K L
Sbjct: 746 LHAAAEAGHVD-ICHMLVQAGANIDTCSEDQRTPLMEAA---ENNHLEAVKYLIKAGALV 801
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D G + +H+A+ G +++ LL++ + +++ Q + G T + A KH+++V+L
Sbjct: 802 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNG-QMDVNCQDDGGWTPMIWATEYKHVDLVKL 860
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ +G+ + I+D + LH AA SG V I IL ++ + +G SPL A E
Sbjct: 861 LLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENR 920
Query: 187 GDVAVTLVNK 196
D V +++
Sbjct: 921 YDCVVLFLSR 930
Score = 60.1 bits (144), Expect = 3e-09
Identities = 48/150 (32%), Positives = 71/150 (47%), Gaps = 9/150 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G E VQ +LS V +DD G P+ WA ++ +++ +LLS I+
Sbjct: 812 LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDIN-- 869
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVV 124
I D +H A+ G V I E LL DL A N G + LH+A + + V
Sbjct: 870 -IRDNEENICLHWAAFSGCVDIAEILL----AAKCDLHAVNIHGDSPLHIAARENRYDCV 924
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSV 154
L + R + V +K+ G+ PL A+ + V
Sbjct: 925 VLFLSRDSDVTLKNKEGETPLQCASLNSQV 954
>At3g09890 [R] KOG0504 FOG: Ankyrin repeat
Length = 185
Score = 63.9 bits (154), Expect = 2e-10
Identities = 44/117 (37%), Positives = 62/117 (52%), Gaps = 8/117 (6%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG 139
A+ G V L +++ + +D + +ALHLAC HL VQLL+ERGA + +KD
Sbjct: 46 AAQAGDVAALRTAIDN-LNGRVDEPLEDNDSALHLACLYGHLPCVQLLLERGADMEVKDE 104
Query: 140 LGQLPLHRAAASGSVGIVSILCDK-NSPVNIK------DKNGWSPLFHALAEGHGDV 189
+PLH A A G + IV +L + +SP +K D G +PL HA H DV
Sbjct: 105 DEAIPLHDACAGGYLEIVQLLFSRASSPECVKRMIETADIEGDTPLHHAARGEHVDV 161
>SPAC2F7.10 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 642
Score = 63.5 bits (153), Expect = 2e-10
Identities = 53/186 (28%), Positives = 85/186 (45%), Gaps = 7/186 (3%)
Query: 1 MGADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
MG+ FL A G+ + V+ ++S V D+ G LHWA QQ I LL +
Sbjct: 1 MGSLFL---AASQGELDTVKNLISSEKIDVNATDEGGATALHWAALNQQIPICKFLLEH- 56
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKH 120
D++ I + +P+H A+ GSV + L+ H +P L+ G LHLA
Sbjct: 57 -GADVNAIGGDLQAAPIHWAAKRGSVKTVHYLVQHGADPL--LKDKQGFNCLHLAVHAAS 113
Query: 121 LNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFH 180
+V L+ SV ++D PL A+ G+ I + L + V D++ +PL
Sbjct: 114 PLLVVYLLHLDISVDLRDDQQHTPLMWASYHGNEPITNCLLRWGADVLATDEDKMTPLHW 173
Query: 181 ALAEGH 186
++ G+
Sbjct: 174 SIVGGN 179
>Hs10863929_1 [M] KOG4177 Ankyrin
Length = 361
Score = 63.5 bits (153), Expect = 2e-10
Identities = 66/264 (25%), Positives = 116/264 (43%), Gaps = 52/264 (19%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LL A N D + VQQ+L +++ G PLH AV +++I+++LL +
Sbjct: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH----GA 83
Query: 66 DTIL-DESGWSPVHIASSIGSVTILEKLLNHTVE-------------------------- 98
D +L ++G +P +A+ GSV +L+ L+ +
Sbjct: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143
Query: 99 -----PNLDLQ----------ANNGITALHLACSKKHLNVVQLLV-ERGASVRIKDGLGQ 142
N++L+ G TAL A K H+ V+++L+ E GA V D +G+
Sbjct: 144 LYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGR 203
Query: 143 LPLHRAAASGS----VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYH 198
L A S I +L D + VN++ + G +PL A+ + H + L+ + H
Sbjct: 204 NALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEH 263
Query: 199 ALWEGETDNDDLSIDKICVDAKVK 222
+ +TD+D + + V+ K+K
Sbjct: 264 -IEINDTDSDGKTALLLAVELKLK 286
>At5g40160 [R] KOG0504 FOG: Ankyrin repeat
Length = 315
Score = 63.2 bits (152), Expect = 3e-10
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 5/176 (2%)
Query: 55 ILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHL 114
++L +K +L I +S W P+ + + +++ L+ + ++ + D+ +N TALH
Sbjct: 135 VILQQNEKPNLKMISTKS-WKPLQTLALSMQIQLMDNLIENGLDID-DVDKDNQ-TALHK 191
Query: 115 ACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
A K V+ L+ +GA+ ++D G P+H A G++ V +L N VN+ D G
Sbjct: 192 AIIGKKEAVISHLLRKGANPHLQDRDGAAPIHYAVQVGALQTVKLLFKYNVDVNVADNEG 251
Query: 175 WSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSID-KICVDAKVKDYFLSKV 229
W+PL A+ + D+ L+ A T + L++D +C K Y L K+
Sbjct: 252 WTPLHIAVQSRNRDITKILLTN-GADKTRRTKDGKLALDLALCFGRDFKSYDLVKL 306
>At3g04710_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 333
Score = 63.2 bits (152), Expect = 3e-10
Identities = 46/154 (29%), Positives = 75/154 (47%), Gaps = 8/154 (5%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G+ E ++++LS G + + PL WA Q N +++LL + + +
Sbjct: 126 LHHAAGTGEIELLKELLSR--GVPVDSESESGTPLIWAAGHDQKNAVEVLLEHNANPNAE 183
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
T E +P+ A + GS++ LE L+ + N+ G T LH+A +L ++
Sbjct: 184 T---EDNITPLLSAVAAGSLSCLELLVKAGAKANVFA---GGATPLHIAADIGNLELINC 237
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
L++ GA KD G PL AAA + +V IL
Sbjct: 238 LLKAGADPNQKDEEGNRPLEVAAARDNRKVVEIL 271
Score = 60.5 bits (145), Expect = 2e-09
Identities = 59/189 (31%), Positives = 91/189 (47%), Gaps = 11/189 (5%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKID 64
L+HAA G E V+ +L + GA + + G LH A + ++ LLS +D
Sbjct: 93 LVHAA-RQGQIETVKYLLEQ--GADPNIASELGATALHHAAGTGEIELLKELLSRGVPVD 149
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
++ ESG +P+ A+ +E LL H PN + + N IT L A + L+ +
Sbjct: 150 SES---ESG-TPLIWAAGHDQKNAVEVLLEHNANPNAETEDN--ITPLLSAVAAGSLSCL 203
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
+LLV+ GA + G G PLH AA G++ +++ L + N KD+ G PL A A
Sbjct: 204 ELLVKAGAKANVFAG-GATPLHIAADIGNLELINCLLKAGADPNQKDEEGNRPLEVAAAR 262
Query: 185 GHGDVAVTL 193
+ V L
Sbjct: 263 DNRKVVEIL 271
Score = 52.4 bits (124), Expect = 5e-07
Identities = 39/144 (27%), Positives = 72/144 (49%), Gaps = 3/144 (2%)
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
+++I D + +H A+ G I LL ++ N D + G T L A + + V
Sbjct: 47 VESIKDANKRGALHFAAREGQTEICRYLLEE-LKLNADAKDETGDTPLVHAARQGQIETV 105
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
+ L+E+GA I LG LH AA +G + ++ L + PV+ + ++G +PL A
Sbjct: 106 KYLLEQGADPNIASELGATALHHAAGTGEIELLKELLSRGVPVDSESESG-TPLIWAAGH 164
Query: 185 GHGDVAVTLVNKYHALWEGETDND 208
+ AV ++ +++A ET+++
Sbjct: 165 DQKN-AVEVLLEHNANPNAETEDN 187
>Hs8923104 [R] KOG0504 FOG: Ankyrin repeat
Length = 420
Score = 62.8 bits (151), Expect = 4e-10
Identities = 44/161 (27%), Positives = 79/161 (48%), Gaps = 7/161 (4%)
Query: 38 RYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDES---GWSPVHIASSIGSVTILEKLLN 94
R+PLH A +D + L S +++ + E GW+PVH A+ G + L +L+
Sbjct: 23 RFPLHRAC---RDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVR 79
Query: 95 HTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSV 154
N+ T H+A H + L++ GA++ D G+ P+H+AA SGS+
Sbjct: 80 AGATLNVST-TRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSL 138
Query: 155 GIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
+S L + V++++ +G + A +G + A +L+N
Sbjct: 139 ECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQSLLN 179
>Hs10835177_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 427
Score = 62.8 bits (151), Expect = 4e-10
Identities = 55/198 (27%), Positives = 96/198 (47%), Gaps = 11/198 (5%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGAVK-----VKDDDGRYPLHWAVSFQQDNIIDILLS 58
D +LH A ++ ++ V+ +L G + +++D + PLH AV +Q+++++ LL
Sbjct: 3 DSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLR 62
Query: 59 YMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNL-DLQANNGITALHLACS 117
+ L LD G S +H+A+ G +L LL H L D +G+ A+HLA
Sbjct: 63 AGADLSL---LDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM 119
Query: 118 KKHLNVVQLLVERGASVRIKD-GLGQLPLHRAAASGSVGIVS-ILCDKNSPVNIKDKNGW 175
L + LLV GA V ++ G+ LH A ++ + +L + ++ V+ +G
Sbjct: 120 SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT 179
Query: 176 SPLFHALAEGHGDVAVTL 193
+PL A G +A L
Sbjct: 180 TPLHIAAGRGSTRLAALL 197
>Hs20557885 [R] KOG0504 FOG: Ankyrin repeat
Length = 395
Score = 62.4 bits (150), Expect = 5e-10
Identities = 44/131 (33%), Positives = 65/131 (49%), Gaps = 6/131 (4%)
Query: 60 MKKIDLDTILDES---GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLAC 116
+ K+ I+DE G++ +H+A+ V + E LL H NLD+Q N TALHLA
Sbjct: 5 LSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAE-LLVHQGNANLDIQNVNQQTALHLAV 63
Query: 117 SKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWS 176
++H +V+LLV GA + I+D G PLH A ++ + L D + W
Sbjct: 64 ERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKV--DAAWE 121
Query: 177 PLFHALAEGHG 187
P + L G G
Sbjct: 122 PSKNTLIMGLG 132
>CE07175 [R] KOG0508 Ankyrin repeat protein
Length = 656
Score = 62.4 bits (150), Expect = 5e-10
Identities = 50/166 (30%), Positives = 76/166 (45%), Gaps = 6/166 (3%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDES-----GWSPVHIASSIGSVTI 88
D DGRYPL A N+++ LL + +++ G P+ AS+ G + I
Sbjct: 45 DQDGRYPLVIAARNGHANVVEYLLEIGADPSVRGVVEFDNENIQGTPPLWAASAAGHIEI 104
Query: 89 LEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRA 148
+ KLL +++ N T L AC HL++V+ L+E+GA I + G L A
Sbjct: 105 V-KLLIEKANADVNQATNTRSTPLRGACYDGHLDIVKYLLEKGADPHIPNRHGHTCLMIA 163
Query: 149 AASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
+ VGIV L VN K + G + L A G+ +V L+
Sbjct: 164 SYRNKVGIVEELLKTGIDVNKKTERGNTALHDAAESGNVEVVKILL 209
>7300995 [T] KOG0507 CASK-interacting adaptor protein (caskin) and related
proteins with ankyrin repeats and SAM domain
Length = 1315
Score = 62.4 bits (150), Expect = 5e-10
Identities = 48/173 (27%), Positives = 77/173 (43%), Gaps = 16/173 (9%)
Query: 1 MGADFLLHAACMNGDTEKVQQILSEFPG------------AVKVKDDDGRYPLHWAVSFQ 48
MG D A NG+ ++++L++ V V+D G LH A
Sbjct: 1 MGKDQEFLEAARNGNISHIEKVLTQKAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNG 60
Query: 49 QDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEP-NLDLQANN 107
++I+ +LL++ +L D G SP+H+A+ G I+ LL H P + +LQ
Sbjct: 61 HEDIVRLLLAHEASPNLP---DSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIE 117
Query: 108 GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
T LH A H + LL+ A +++ G+ PL AA G + V +L
Sbjct: 118 QETPLHCAAQHGHTGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQML 170
Score = 58.5 bits (140), Expect = 7e-09
Identities = 60/212 (28%), Positives = 92/212 (43%), Gaps = 31/212 (14%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKK---I 63
LH AC+NG E + ++L + + D G PLH A + I+ +LL++ +
Sbjct: 53 LHHACLNGH-EDIVRLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASA 111
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
+L TI E +P+H A+ G L LL+H +PN ++ + G T L LA L
Sbjct: 112 NLQTIEQE---TPLHCAAQHGHTGALALLLHHDADPN--MRNSRGETPLDLAAQYGRLQA 166
Query: 124 VQLLV---------------ERGA---SVRIKDGLGQLP---LHRAAASGSVGIVSILCD 162
VQ+L+ ERG S P LH A+ +G +V +L
Sbjct: 167 VQMLIRAHPELIAHLGTEALERGTPSPSSPASPSRAIFPHTCLHLASRNGHKSVVEVLLS 226
Query: 163 KNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
VN+ +G + L A G +V TL+
Sbjct: 227 AGVSVNLLTPSG-TALHEAALCGKENVVRTLL 257
Score = 54.3 bits (129), Expect = 1e-07
Identities = 40/136 (29%), Positives = 63/136 (45%), Gaps = 5/136 (3%)
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
+ D G+S +H A G I+ LL H PNL + G + LHLA +V+LL
Sbjct: 44 VQDSGGYSALHHACLNGHEDIVRLLLAHEASPNLP--DSRGSSPLHLAAWAGETEIVRLL 101
Query: 128 VE---RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
+ R AS ++ + PLH AA G G +++L ++ N+++ G +PL A
Sbjct: 102 LTHPYRPASANLQTIEQETPLHCAAQHGHTGALALLLHHDADPNMRNSRGETPLDLAAQY 161
Query: 185 GHGDVAVTLVNKYHAL 200
G L+ + L
Sbjct: 162 GRLQAVQMLIRAHPEL 177
Score = 51.6 bits (122), Expect = 9e-07
Identities = 38/129 (29%), Positives = 64/129 (49%), Gaps = 15/129 (11%)
Query: 80 ASSIGSVTILEKLLNHTVE-----------PNLDLQANNGITALHLACSKKHLNVVQLLV 128
A+ G+++ +EK+L + +++Q + G +ALH AC H ++V+LL+
Sbjct: 10 AARNGNISHIEKVLTQKAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNGHEDIVRLLL 69
Query: 129 ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCD---KNSPVNIKDKNGWSPLFHALAEG 185
AS + D G PLH AA +G IV +L + + N++ +PL A G
Sbjct: 70 AHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQETPLHCAAQHG 129
Query: 186 H-GDVAVTL 193
H G +A+ L
Sbjct: 130 HTGALALLL 138
>Hs13376003 [M] KOG4177 Ankyrin
Length = 274
Score = 62.0 bits (149), Expect = 7e-10
Identities = 52/183 (28%), Positives = 92/183 (49%), Gaps = 15/183 (8%)
Query: 1 MGADFLLHAACMNGDTEKVQQIL-SEFPG-AVKVKDDDGRYPLHWAVSFQQDNIIDILLS 58
+G LH A M+G + +L SE+ + K +DG PLH A + +D+ + +LL
Sbjct: 79 IGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLE 138
Query: 59 YMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSK 118
+ ++D L + G +P+ +A + ++ LL+H N+D+Q NG L A K
Sbjct: 139 FKAEVDP---LSDKGTTPLQLAIIREKSSCVKILLDHNA--NIDIQ--NGFL-LRYAVIK 190
Query: 119 KHLNVVQLLVERGASV---RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGW 175
+ + ++ ++RGA R++DG Q PLH +A V +L + + N ++ G
Sbjct: 191 SNHSYCRMFLQRGADTNLGRLEDG--QTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQ 248
Query: 176 SPL 178
+PL
Sbjct: 249 TPL 251
>7295892 [M] KOG4177 Ankyrin
Length = 342
Score = 62.0 bits (149), Expect = 7e-10
Identities = 57/228 (25%), Positives = 94/228 (41%), Gaps = 39/228 (17%)
Query: 3 ADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDD-------------------------- 36
+D LH A M GD + ++L V KD+D
Sbjct: 30 SDVQLHMAAMRGDEVALLRVLDSGKVHVDCKDEDGTTPLILAAAGGHTYCVMELLDQGAD 89
Query: 37 -------GRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
G PL +A +++ IL+ +D + G +P+ +A G V I+
Sbjct: 90 PNSRRLTGTTPLFFAAQGGHLDVVKILIKAGASVDTPS---ADGGTPLFVACQGGHVKIV 146
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAA 149
+LL+ N++ + T + ++ H V+ LL++ GA + IK G PL AA
Sbjct: 147 RELLD--CGANVNAHMKDRATPVFISAQNGHRTVLSLLIQAGAEIDIKRIDGATPLWIAA 204
Query: 150 ASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKY 197
G I +L + V+ +G +PLF A +GH V +T++ KY
Sbjct: 205 QMGQDHICKVLLQNGANVDTVRCDGATPLFKAAHKGHAAV-ITVLLKY 251
Score = 61.6 bits (148), Expect = 9e-10
Identities = 42/125 (33%), Positives = 63/125 (49%), Gaps = 2/125 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
DE G +P+ +A++ G + +LL+ +PN + G T L A HL+VV++L++
Sbjct: 61 DEDGTTPLILAAAGGHTYCVMELLDQGADPNS--RRLTGTTPLFFAAQGGHLDVVKILIK 118
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
GASV G PL A G V IV L D + VN K+ +P+F + GH V
Sbjct: 119 AGASVDTPSADGGTPLFVACQGGHVKIVRELLDCGANVNAHMKDRATPVFISAQNGHRTV 178
Query: 190 AVTLV 194
L+
Sbjct: 179 LSLLI 183
Score = 50.1 bits (118), Expect = 3e-06
Identities = 43/129 (33%), Positives = 64/129 (49%), Gaps = 8/129 (6%)
Query: 19 VQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVH 78
V +L + + +K DG PL A QD+I +LL ++DT+ + G +P+
Sbjct: 178 VLSLLIQAGAEIDIKRIDGATPLWIAAQMGQDHICKVLL--QNGANVDTVRCD-GATPLF 234
Query: 79 IASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIK- 137
A+ G ++ LL + PNL Q NG +ALH A H+ V + LV G+ V +K
Sbjct: 235 KAAHKGHAAVITVLLKY--RPNLG-QLPNGESALHAAAMFGHMTVCKQLVAAGSDVLLKN 291
Query: 138 -DGLGQLPL 145
DGL L L
Sbjct: 292 HDGLTALQL 300
>At5g13530_3 [R] KOG0504 FOG: Ankyrin repeat
Length = 332
Score = 62.0 bits (149), Expect = 7e-10
Identities = 45/165 (27%), Positives = 76/165 (45%), Gaps = 5/165 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC G E V+ IL V + D DG PL +A++ + +L+ +
Sbjct: 13 LHLACRRGSAELVEAILEYGEANVDIVDKDGDPPLVFALAAGSPQCVHVLIKKGANV-RS 71
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ + SG S H+ S G + +LL +PN + G T LH A +KK+ + +
Sbjct: 72 RLREGSGPSVAHVCSYHGQPDCMRELLVAGADPN--AVDDEGETVLHRAVAKKYTDCAIV 129
Query: 127 LVERGA--SVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNI 169
++E G S+ + + PLH A+ +V ++ + +SP I
Sbjct: 130 ILENGGSRSMTVSNAKCLTPLHMCVATWNVAVIKRWVEVSSPEEI 174
Score = 51.2 bits (121), Expect = 1e-06
Identities = 27/80 (33%), Positives = 45/80 (55%), Gaps = 1/80 (1%)
Query: 105 ANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKN 164
A +G TALH A ++ +V+++++ G + I++ +PLH A A G+ VS+L +
Sbjct: 221 AQHGRTALHTAAMANNVELVRVILDAGVNANIRNVHNTIPLHMALARGANSCVSLLLESG 280
Query: 165 SPVNIKDKNGWSPLFHALAE 184
S NI+D G FH A+
Sbjct: 281 SDCNIQDDEG-DNAFHIAAD 299
Score = 48.9 bits (115), Expect = 6e-06
Identities = 47/191 (24%), Positives = 92/191 (47%), Gaps = 18/191 (9%)
Query: 8 HAACMNGDTEKVQQIL--SEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
H +G + ++++L P AV DD+G LH AV+ + + ++L +
Sbjct: 83 HVCSYHGQPDCMRELLVAGADPNAV---DDEGETVLHRAVAKKYTDCAIVILENGGSRSM 139
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLN----HTVEPNLDLQANNGITALHLACS---- 117
T+ + +P+H+ + +V ++++ + + +++ + G TAL +A S
Sbjct: 140 -TVSNAKCLTPLHMCVATWNVAVIKRWVEVSSPEEISQAINIPSPVG-TALCMAASIRKD 197
Query: 118 --KKHLNVVQLLVERGASVRIKDGL-GQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
K+ +VQ+L+ GA +D G+ LH AA + +V +V ++ D NI++ +
Sbjct: 198 HEKEGRELVQILLAAGADPTAQDAQHGRTALHTAAMANNVELVRVILDAGVNANIRNVHN 257
Query: 175 WSPLFHALAEG 185
PL ALA G
Sbjct: 258 TIPLHMALARG 268
>Hs7705748 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 835
Score = 61.6 bits (148), Expect = 9e-10
Identities = 40/141 (28%), Positives = 70/141 (49%), Gaps = 2/141 (1%)
Query: 69 LDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV 128
L +G++ +H+A + ++ LL+ + + G+TALH+A HL +L+
Sbjct: 97 LTRNGFTALHLAVYKDNAELITSLLHSGAD--IQQVGYGGLTALHIATIAGHLEAADVLL 154
Query: 129 ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGD 188
+ GA+V I+D + PLH AA G + +L + VN+ + G PL A A+G +
Sbjct: 155 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN 214
Query: 189 VAVTLVNKYHALWEGETDNDD 209
+A L+ + DN+D
Sbjct: 215 IAKLLMEEGSKADVNAQDNED 235
Score = 50.4 bits (119), Expect = 2e-06
Identities = 41/178 (23%), Positives = 81/178 (45%), Gaps = 7/178 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + G E +L + V ++D PLH A + + + +LL + +++
Sbjct: 138 LHIATIAGHLEAAD-VLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVS 196
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
E G P+H+AS+ G + I + L+ + +++ Q N LH H ++V+
Sbjct: 197 ---GEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKY 253
Query: 127 LVERGASVR--IKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWS-PLFHA 181
L++ V+ + + G PLH A +G + + + ++ +N +S FH+
Sbjct: 254 LLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHS 311
>Hs7662406 [R] KOG0504 FOG: Ankyrin repeat
Length = 692
Score = 61.6 bits (148), Expect = 9e-10
Identities = 57/202 (28%), Positives = 90/202 (44%), Gaps = 7/202 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L A G TE V Q++++ GA GR PLH A + ++ ILL DLD
Sbjct: 14 LLVAAYKGQTENVVQLINK--GARVAVTKHGRTPLHLAANKGHLPVVQILLK--AGCDLD 69
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ D+ + +H A+ +G+ I+ L++ LD Q +G TALH A +L
Sbjct: 70 -VQDDGDQTALHRATVVGNTEIIAALIHEGCA--LDRQDKDGNTALHEASWHGFSQSAKL 126
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
LV+ GA+V K+ G LH A + +L S ++K+ G + L A H
Sbjct: 127 LVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNH 186
Query: 187 GDVAVTLVNKYHALWEGETDND 208
+ L+ + ++ E D
Sbjct: 187 LSIIRLLLTAFCSVHEKNQAGD 208
Score = 57.4 bits (137), Expect = 2e-08
Identities = 52/192 (27%), Positives = 84/192 (43%), Gaps = 6/192 (3%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMK 61
G LH A + G+TE + ++ E A+ +D DG LH A +L+
Sbjct: 74 GDQTALHRATVVGNTEIIAALIHE-GCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
Query: 62 KIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHL 121
+ +++G + +H+A LL DL+ N G T LH+A HL
Sbjct: 133 NV---LAKNKAGNTALHLACQNSHSQSTRVLL--LAGSRADLKNNAGDTCLHVAARYNHL 187
Query: 122 NVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
++++LL+ SV K+ G LH AAA + IL + + I + G +PL A
Sbjct: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
Query: 182 LAEGHGDVAVTL 193
+ +VA+ L
Sbjct: 248 RYHNNPEVALLL 259
>Hs4502753 [R] KOG0504 FOG: Ankyrin repeat
Length = 166
Score = 61.6 bits (148), Expect = 9e-10
Identities = 38/106 (35%), Positives = 55/106 (51%), Gaps = 3/106 (2%)
Query: 84 GSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQL 143
GS I +LL PN+ Q +G + +H A L+ +++LVE GA V + DG G L
Sbjct: 52 GSTAIALELLKQGASPNV--QDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGAL 109
Query: 144 PLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
P+H A G +VS L S ++ +D G +PL AL G D+
Sbjct: 110 PIHLAVQEGHTAVVSFLA-AESDLHRRDARGLTPLELALQRGAQDL 154
>Hs18561834 [M] KOG4177 Ankyrin
Length = 568
Score = 61.6 bits (148), Expect = 9e-10
Identities = 45/156 (28%), Positives = 78/156 (49%), Gaps = 11/156 (7%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
+ V ++ R LH+AV + +D LL + ++D + D+ G + +H+A+ GS+ ++
Sbjct: 94 INVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD---VADKHGLTVIHLAAWSGSLEVM 150
Query: 90 EKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVVQLLVE--RGASVRIKDGLGQLPL 145
L V+ D +A N G++ALH A H+ +V+ L++ + D G+ P
Sbjct: 151 LML----VKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPF 206
Query: 146 HRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
AA G V ++ L N + KDK WS L+ A
Sbjct: 207 LLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTA 242
Score = 57.0 bits (136), Expect = 2e-08
Identities = 35/119 (29%), Positives = 59/119 (49%), Gaps = 2/119 (1%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG 139
A+ ++ ++EKL V N+++ N TALH A + HL+ V L++ A V + D
Sbjct: 75 AAKSNNLDLMEKLFEKKV--NINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADK 132
Query: 140 LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYH 198
G +H AA SGS+ ++ +L + K+++G S L A H + L+ H
Sbjct: 133 HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
Score = 51.2 bits (121), Expect = 1e-06
Identities = 45/170 (26%), Positives = 74/170 (43%), Gaps = 8/170 (4%)
Query: 37 GRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHT 96
G LH A + +LL+ + I+ ++E S + IA+ G +++ LL+
Sbjct: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINE---MNELNISSLQIATRNGHASLVNFLLSEN 336
Query: 97 VEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGI 156
V+ + ++ + LHL H+ VV L+ + I + Q PLH AA G+V +
Sbjct: 337 VDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVEL 394
Query: 157 VSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV--NKYHALWEGE 204
V L + DK G + L A H V L+ +Y+A W E
Sbjct: 395 VETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYA-WREE 443
>Hs18254470 [R] KOG0504 FOG: Ankyrin repeat
Length = 429
Score = 61.6 bits (148), Expect = 9e-10
Identities = 56/195 (28%), Positives = 81/195 (40%), Gaps = 20/195 (10%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
G LH AC G T V +L GA + D DG+ PLH ++LL +
Sbjct: 147 GGRTALHEACAAGHTACVHVLL--VAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFG 204
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLAC---- 116
++D + +E +P+H+A+ +G V + + LL P D + G T L AC
Sbjct: 205 ARVDGRS--EEEEETPLHVAARLGHVELADLLLRRGACP--DARNAEGWTPLLAACDVRC 260
Query: 117 ---------SKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV 167
+ + L + LL+ GA D Q PLH A G +V +L
Sbjct: 261 QSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSA 320
Query: 168 NIKDKNGWSPLFHAL 182
N D G +PL AL
Sbjct: 321 NTMDYGGHTPLHCAL 335
Score = 56.2 bits (134), Expect = 4e-08
Identities = 39/128 (30%), Positives = 63/128 (48%), Gaps = 4/128 (3%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
+E +P+H+A+S G +L LL P+ A G TALH AC+ H V +L+
Sbjct: 113 EEELTTPLHVAASRGHTEVLRLLLRRRARPD---SAPGGRTALHEACAAGHTACVHVLLV 169
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK-DKNGWSPLFHALAEGHGD 188
GA I D G+ PLH G++ +L + V+ + ++ +PL A GH +
Sbjct: 170 AGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVE 229
Query: 189 VAVTLVNK 196
+A L+ +
Sbjct: 230 LADLLLRR 237
>At2g31820 [R] KOG0504 FOG: Ankyrin repeat
Length = 662
Score = 61.6 bits (148), Expect = 9e-10
Identities = 62/233 (26%), Positives = 101/233 (42%), Gaps = 44/233 (18%)
Query: 4 DFLLHAACMNGDTEKVQQIL----SEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSY 59
D LH A G+ KV++++ E + ++ +G PL+ A +++ +L +
Sbjct: 152 DSSLHIAARTGNLSKVKELIRGCGDELKELLSKQNLEGETPLYTAAENGHSIVVEEMLKH 211
Query: 60 MKKIDLDT--ILDESGWSPVHIASSIGSVTILEKLLN----------------------- 94
M DL+T I +G+ P H+A+ G + +L+ LL
Sbjct: 212 M---DLETASIAARNGFDPFHVAAKQGHLEVLKILLETFPNLAMTTDLSCTTALHTAATQ 268
Query: 95 -HTVEPNLDLQA---------NNGITALHLACSKKHLNVVQLLVERGASVRIK-DGLGQL 143
H NL L+ NNG TALH A H+ VV+ L+ + S+ + D GQ
Sbjct: 269 GHIDVVNLLLETDSNLAKIAKNNGKTALHSAARMGHVEVVKSLIGKDPSIGFRTDKKGQT 328
Query: 144 PLHRAAASGSVGIVSILCDKNSPV-NIKDKNGWSPLFHALAEGHGDVAVTLVN 195
LH A + GIV L + V +++D G +PL A +G + LV+
Sbjct: 329 ALHMAVKGQNDGIVVELVKPDVAVLSVEDNKGNTPLHIATNKGRIKIVRCLVS 381
Score = 60.5 bits (145), Expect = 2e-09
Identities = 36/126 (28%), Positives = 65/126 (51%), Gaps = 2/126 (1%)
Query: 73 GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGA 132
G +P++ A+ G ++E++L H + A NG H+A + HL V+++L+E
Sbjct: 189 GETPLYTAAENGHSIVVEEMLKHMDLETASIAARNGFDPFHVAAKQGHLEVLKILLETFP 248
Query: 133 SVRIKDGLG-QLPLHRAAASGSVGIVSILCDKNSPV-NIKDKNGWSPLFHALAEGHGDVA 190
++ + L LH AA G + +V++L + +S + I NG + L A GH +V
Sbjct: 249 NLAMTTDLSCTTALHTAATQGHIDVVNLLLETDSNLAKIAKNNGKTALHSAARMGHVEVV 308
Query: 191 VTLVNK 196
+L+ K
Sbjct: 309 KSLIGK 314
>Hs20472035 [R] KOG0504 FOG: Ankyrin repeat
Length = 361
Score = 61.2 bits (147), Expect = 1e-09
Identities = 49/203 (24%), Positives = 97/203 (47%), Gaps = 7/203 (3%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI 63
D LLH A +G + + + + ++ + D + PLH A S + + LL +
Sbjct: 38 DTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAV 97
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
D L ++ W+P+ +A + ++ ++++L+ H P L+ +G + H+A + +
Sbjct: 98 D---CLKKADWTPLMMACTRKNLGVIQELVEHGANPL--LKNKDGWNSFHIASREGDPLI 152
Query: 124 VQ-LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDK-NSPVNIKDKNGWSPLFHA 181
+Q LL + + + + + PLH AA G + V +L + + +D G + L A
Sbjct: 153 LQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDA 212
Query: 182 LAEGHGDVAVTLVNKYHALWEGE 204
+ GH DVA L++++ A E
Sbjct: 213 IQCGHIDVARLLLDEHGACLSAE 235
>Hs18254462 [R] KOG0504 FOG: Ankyrin repeat
Length = 453
Score = 61.2 bits (147), Expect = 1e-09
Identities = 50/190 (26%), Positives = 84/190 (43%), Gaps = 13/190 (6%)
Query: 1 MGADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
+G LH AC + V+ +L+ F V ++G PLH + +LL
Sbjct: 141 VGGRAALHEACARAQFDCVRLLLT-FGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAG 199
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACS--- 117
++L ES +P+H+A++ G + L H + + L+ + G TAL+ AC+
Sbjct: 200 ATVNLAA--GESQETPLHVAAARGLEQHVALYLEHGAD--VGLRTSQGETALNAACAGAE 255
Query: 118 -----KKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDK 172
++H + L+E GA R PLH A ASG G+ +L + + +
Sbjct: 256 GPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACASGCGGLAELLLRYGARAEVPNG 315
Query: 173 NGWSPLFHAL 182
G +P+ AL
Sbjct: 316 AGHTPMDCAL 325
>Hs17485543 [R] KOG0504 FOG: Ankyrin repeat
Length = 353
Score = 61.2 bits (147), Expect = 1e-09
Identities = 36/117 (30%), Positives = 61/117 (51%), Gaps = 2/117 (1%)
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
+SG P+ +A+ + + T L K+L + +LD + +G+TA+H A +++ + L++
Sbjct: 147 DSGECPLSLAAQLDNATDLLKVLKNG-GAHLDFRTRDGLTAVHCATRQRNAAALTTLLDL 205
Query: 131 GASVRIKDGLGQLPL-HRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
GAS KD G PL H A G +L ++ + I D+NGW + A GH
Sbjct: 206 GASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGH 262
>At4g32500 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 880
Score = 60.8 bits (146), Expect = 1e-09
Identities = 54/195 (27%), Positives = 84/195 (42%), Gaps = 24/195 (12%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
A GD + Q+L + D +GR LH A S + +LL
Sbjct: 549 AAARGDDLLLHQLLKRGSNPNET-DKNGRTALHIAASKGSQYCVVLLL------------ 595
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALH--------LACSKKHL 121
E G P +I S GSV + E ++ E N L + NG T LA + +L
Sbjct: 596 -EHGADP-NIRDSEGSVPLWEAIIGRH-EENAKLLSENGATLSFDTVGYFSCLAVGQNNL 652
Query: 122 NVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
N ++ +V+ G + + D G LHRA + G++ IV L +K + ++ D GW+ A
Sbjct: 653 NALKDIVKYGGDISLSDVNGTTALHRAVSEGNLEIVQFLLEKGADMDKPDVYGWTARALA 712
Query: 182 LAEGHGDVAVTLVNK 196
+GH D+ N+
Sbjct: 713 EHQGHEDIKALFYNQ 727
>Hs18551475 [R] KOG0504 FOG: Ankyrin repeat
Length = 258
Score = 60.5 bits (145), Expect = 2e-09
Identities = 45/167 (26%), Positives = 80/167 (46%), Gaps = 7/167 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
+H A G K+++++ + + ++D R L+WA + ++ +L+ +K LD
Sbjct: 42 IHKAASRGQAWKLERMMKKTTMDLNIRDAKKRTALYWACANGHAEVVTLLVD--RKCQLD 99
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNL-DLQANNGITALHLACSKKHLNVVQ 125
+LD + + A L++ +PN+ D+ N TA+H A + ++L+VV
Sbjct: 100 -VLDGENRTILMKALQCQREACANILIDSGADPNIVDVYGN---TAVHYAVNSENLSVVA 155
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDK 172
L+ GA + +K+ G PL A S IV L KN+ N DK
Sbjct: 156 KLLSCGADIEVKNKAGHTPLLLAIRKRSEEIVEFLLTKNANANAVDK 202
Score = 48.5 bits (114), Expect = 8e-06
Identities = 34/119 (28%), Positives = 59/119 (49%), Gaps = 1/119 (0%)
Query: 77 VHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRI 136
+H A+S G LE+++ T +L+++ TAL+ AC+ H VV LLV+R + +
Sbjct: 42 IHKAASRGQAWKLERMMKKTTM-DLNIRDAKKRTALYWACANGHAEVVTLLVDRKCQLDV 100
Query: 137 KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
DG + L +A +IL D + NI D G + + +A+ + V L++
Sbjct: 101 LDGENRTILMKALQCQREACANILIDSGADPNIVDVYGNTAVHYAVNSENLSVVAKLLS 159
>Hs17441942 [R] KOG0504 FOG: Ankyrin repeat
Length = 361
Score = 60.5 bits (145), Expect = 2e-09
Identities = 48/156 (30%), Positives = 76/156 (47%), Gaps = 6/156 (3%)
Query: 33 KDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKL 92
+D G PLH A F +++ LL L+T G P+H A+ G +T L KL
Sbjct: 117 QDASGVSPLHLAARFGHPVLVEWLLHEGHSATLET---REGARPLHHAAVSGDLTCL-KL 172
Query: 93 LNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV-ERGASVRIKDGLGQLPLHRAAAS 151
L +++ + +G + L+LAC + HL++ Q LV + GA V ++ G LH AAA
Sbjct: 173 LTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAAR 232
Query: 152 GSVG-IVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
G +V ++ + + +D G + L A GH
Sbjct: 233 GHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGH 268
Score = 55.1 bits (131), Expect = 8e-08
Identities = 44/140 (31%), Positives = 66/140 (46%), Gaps = 17/140 (12%)
Query: 72 SGWSPVHIASSIGSVTIL----------------EKLLNHTVEPNLDLQANNGITALHLA 115
+G +P H A++ GS+ L E L+ L Q +G++ LHLA
Sbjct: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQARPLELSLSPVELSGLRDQDASGVSPLHLA 128
Query: 116 CSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL-CDKNSPVNIKDKNG 174
H +V+ L+ G S ++ G PLH AA SG + + +L S VN + ++G
Sbjct: 129 ARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSG 188
Query: 175 WSPLFHALAEGHGDVAVTLV 194
SPL+ A EGH +A LV
Sbjct: 189 ASPLYLACQEGHLHLAQFLV 208
Score = 49.7 bits (117), Expect = 3e-06
Identities = 40/149 (26%), Positives = 70/149 (46%), Gaps = 6/149 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A ++GD ++ + + +V + G PL+ A Q+ + + +K D
Sbjct: 158 LHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLAC---QEGHLHLAQFLVKDCGAD 214
Query: 67 TILDE-SGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
L G S +H A++ G +++ L+ T + L + N G TALH A H ++
Sbjct: 215 VHLRALDGMSALHAAAARGHYSLVVWLVTFT-DIGLTARDNEGATALHFAARGGHTPILD 273
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSV 154
L+ G + ++D G PLH AA +G +
Sbjct: 274 RLLLMGTPI-LRDSWGGTPLHDAAENGQM 301
>7294194 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 1023
Score = 60.5 bits (145), Expect = 2e-09
Identities = 58/220 (26%), Positives = 92/220 (41%), Gaps = 43/220 (19%)
Query: 9 AACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDT 67
AAC++GD ++V Q+L + GA + + DG LH A ++++ L+ I+
Sbjct: 52 AACLSGDKDEVVQLLDQ--GADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQ- 108
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVVQ 125
D GW+P+H +S G V+I L VE D+ A N G AL LA +H+ ++
Sbjct: 109 --DNEGWTPLHATASCGFVSIARYL----VENGADVAAVNSDGDLALDLAIDVQHMAMID 162
Query: 126 LLVERGASVRIK-------------------------------DGLGQLPLHRAAASGSV 154
+ + + I G LH AAA G
Sbjct: 163 YMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYT 222
Query: 155 GIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
++ +L V+ +D +GW+PL A G + A LV
Sbjct: 223 KVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLV 262
Score = 54.3 bits (129), Expect = 1e-07
Identities = 27/68 (39%), Positives = 40/68 (58%)
Query: 107 NGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSP 166
+G+TALH AC +L++V+ LVERGA + +D G PLH A+ G V I L + +
Sbjct: 78 DGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGAD 137
Query: 167 VNIKDKNG 174
V + +G
Sbjct: 138 VAAVNSDG 145
>Hs13249344 [T] KOG1217 Fibrillins and related proteins containing Ca2+-binding
EGF-like domains
Length = 2471
Score = 60.1 bits (144), Expect = 3e-09
Identities = 51/195 (26%), Positives = 97/195 (49%), Gaps = 6/195 (3%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI 63
+ LH A + +++L A +D+ GR PLH AV+ + IL+ +
Sbjct: 1878 EMALHLAARYSRADAAKRLLDAGADA-NAQDNMGRCPLHAAVAADAQGVFQILIRN-RVT 1935
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
DLD +++ G +P+ +A+ + ++ +L+N + +++ ++G +ALH A + ++
Sbjct: 1936 DLDARMND-GTTPLILAARLAVEGMVAELIN--CQADVNAVDDHGKSALHWAAAVNNVEA 1992
Query: 124 VQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
LL++ GA+ ++D + PL AA GS IL D + +I D P A
Sbjct: 1993 TLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARD 2052
Query: 184 EGHGDVAVTLVNKYH 198
H D+ V L+++Y+
Sbjct: 2053 HMHHDI-VRLLDEYN 2066
Score = 50.4 bits (119), Expect = 2e-06
Identities = 44/164 (26%), Positives = 72/164 (43%), Gaps = 4/164 (2%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL 93
D G LH A + + + LL + D G P+H A + + + + L+
Sbjct: 1874 DRTGEMALHLAARYSRADAAKRLLDAGADANAQ---DNMGRCPLHAAVAADAQGVFQILI 1930
Query: 94 NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGS 153
+ V +LD + N+G T L LA +V L+ A V D G+ LH AAA +
Sbjct: 1931 RNRVT-DLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNN 1989
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKY 197
V +L + +++D +PLF A EG + A L++ +
Sbjct: 1990 VEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHF 2033
>At5g60070 [R] KOG0504 FOG: Ankyrin repeat
Length = 548
Score = 60.1 bits (144), Expect = 3e-09
Identities = 51/193 (26%), Positives = 90/193 (46%), Gaps = 7/193 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFP-GAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
L+ A GD + V +++ + + K +G P H A + +++ +L+ + +L
Sbjct: 77 LYVAAEYGDADVVAELIKYYDLEDAETKARNGFDPFHIAAKQGELDVLRVLME--EHPEL 134
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
+D S + +H A++ G V ++E LL + +NG TALH A H VV+
Sbjct: 135 SMTVDLSNTTALHTAAAQGHVEVVEYLLEAAGSSLAAIAKSNGKTALHSAARNGHAEVVK 194
Query: 126 LL--VERGASVRIKDGLGQLPLHRAAASGSVG-IVSILCDKNSPVNIKDKNGWSPLFHAL 182
+ VE + R D GQ PLH A S+ +V ++ S +N+ D G + L A
Sbjct: 195 AIVAVEPDTATR-TDKKGQTPLHMAVKGQSIDVVVELMKGHRSSLNMADSKGNTALHVAT 253
Query: 183 AEGHGDVAVTLVN 195
+G + L++
Sbjct: 254 RKGRIKIVELLLD 266
Score = 58.2 bits (139), Expect = 1e-08
Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 8/191 (4%)
Query: 8 HAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDT 67
H A G+ + ++ ++ E P D LH A + +++ LL L
Sbjct: 113 HIAAKQGELDVLRVLMEEHPELSMTVDLSNTTALHTAAAQGHVEVVEYLLEAAGS-SLAA 171
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN-GITALHLACSKKHLNVV-Q 125
I +G + +H A+ G +++ ++ VEP+ + + G T LH+A + ++VV +
Sbjct: 172 IAKSNGKTALHSAARNGHAEVVKAIV--AVEPDTATRTDKKGQTPLHMAVKGQSIDVVVE 229
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKN--SP-VNIKDKNGWSPLFHAL 182
L+ +S+ + D G LH A G + IV +L D N SP ++ G +PL A
Sbjct: 230 LMKGHRSSLNMADSKGNTALHVATRKGRIKIVELLLDNNETSPSTKAINRAGETPLDTAE 289
Query: 183 AEGHGDVAVTL 193
GH +A L
Sbjct: 290 KTGHPQIAAVL 300
Score = 52.4 bits (124), Expect = 5e-07
Identities = 39/148 (26%), Positives = 74/148 (49%), Gaps = 7/148 (4%)
Query: 54 DILLSYMKKID-LDTIL---DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI 109
+IL ++M+ D L +L ++ G + +++A+ G ++ +L+ + + + +A NG
Sbjct: 50 EILSNHMESEDELRDLLRKQNQCGETALYVAAEYGDADVVAELIKYYDLEDAETKARNGF 109
Query: 110 TALHLACSKKHLNVVQLLVERGASVRIKDGLGQ-LPLHRAAASGSVGIVSILCDK--NSP 166
H+A + L+V+++L+E + + L LH AAA G V +V L + +S
Sbjct: 110 DPFHIAAKQGELDVLRVLMEEHPELSMTVDLSNTTALHTAAAQGHVEVVEYLLEAAGSSL 169
Query: 167 VNIKDKNGWSPLFHALAEGHGDVAVTLV 194
I NG + L A GH +V +V
Sbjct: 170 AAIAKSNGKTALHSAARNGHAEVVKAIV 197
>7301132 [R] KOG0504 FOG: Ankyrin repeat
Length = 784
Score = 60.1 bits (144), Expect = 3e-09
Identities = 50/188 (26%), Positives = 92/188 (48%), Gaps = 7/188 (3%)
Query: 10 ACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTI 68
AC G + V+ +L GA V+ ++++G PL A S + +LL + I+ T
Sbjct: 69 ACAGGQVDVVKVLLKH--GANVEEQNENGHTPLMEAASAGHVEVAKVLLEHGAGIN--TH 124
Query: 69 LDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV 128
+E S + +A G + ++ LL + + + + TAL A H+ V +LL+
Sbjct: 125 SNEFKESALTLACYKGHLDMVRFLLQAGADQ--EHKTDEMHTALMEASMDGHVEVARLLL 182
Query: 129 ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGD 188
+ GA V + + PL AA G V + ++L ++ + + + G++PL A EGH +
Sbjct: 183 DSGAQVNMPTDSFESPLTLAACGGHVELATLLIERGANIEEVNDEGYTPLMEAAREGHEE 242
Query: 189 VAVTLVNK 196
+ L++K
Sbjct: 243 MVALLLSK 250
Score = 57.0 bits (136), Expect = 2e-08
Identities = 43/149 (28%), Positives = 79/149 (52%), Gaps = 4/149 (2%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
+P+ A+S G + I++ LLNH + N N T L AC+ ++VV++L++ GA+V
Sbjct: 31 TPLMEAASAGHLDIVKLLLNHNADVNAHCATGN--TPLMFACAGGQVDVVKVLLKHGANV 88
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNI-KDKNGWSPLFHALAEGHGDVAVTL 193
++ G PL AA++G V + +L + + +N ++ S L A +GH D+ V
Sbjct: 89 EEQNENGHTPLMEAASAGHVEVAKVLLEHGAGINTHSNEFKESALTLACYKGHLDM-VRF 147
Query: 194 VNKYHALWEGETDNDDLSIDKICVDAKVK 222
+ + A E +TD ++ + +D V+
Sbjct: 148 LLQAGADQEHKTDEMHTALMEASMDGHVE 176
Score = 50.4 bits (119), Expect = 2e-06
Identities = 48/208 (23%), Positives = 92/208 (44%), Gaps = 9/208 (4%)
Query: 9 AACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTI 68
AAC G ++ +L E ++ +D+G PL A + ++ +LLS K +++
Sbjct: 202 AAC--GGHVELATLLIERGANIEEVNDEGYTPLMEAAREGHEEMVALLLS--KGANINAT 257
Query: 69 LDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV 128
+E+ + + +A G + + L+ NL+L A+ T L A + H ++V L+
Sbjct: 258 TEETQETALTLACCGGFMEVAAFLIKEGA--NLELGAS---TPLMEASQEGHTDLVSFLL 312
Query: 129 ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGD 188
++ A+V + G L A +G +L + + + + G +PL A GH
Sbjct: 313 KKKANVHAETQTGDTALTHACENGHTDAAGVLLSYGAELEHESEGGRTPLMKACRAGHLC 372
Query: 189 VAVTLVNKYHALWEGETDNDDLSIDKIC 216
L+ K + + T ND ++ C
Sbjct: 373 TVKFLIQKGANVNKQTTSNDHTALSLAC 400
>7293882 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 762
Score = 60.1 bits (144), Expect = 3e-09
Identities = 62/247 (25%), Positives = 101/247 (40%), Gaps = 38/247 (15%)
Query: 6 LLHAACMNGDTEKVQQILSE--FPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI 63
LL AA N D +V +L P A ++DG +H A ++ +LL Y +
Sbjct: 123 LLEAASRN-DMPEVAALLQHGITPDAA---NEDGLTAMHQACIDNNVEMLQLLLEYGANV 178
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTV------------------EPNLDL-- 103
D D W+P+H A++ G + ++ L+ H E LD
Sbjct: 179 DAQ---DSDKWTPLHAAATCGHLELVRILIRHGANLLAVNTDGNMPYDLCDDEKTLDFIE 235
Query: 104 --QANNGITALHLACSKKHLNVVQL-----LVERGASVRIKDGLGQLPLHRAAASGSVGI 156
A G+T + ++ + L L G + D PLH AAA+G V +
Sbjct: 236 GEMAQRGVTQELIDETRSSTERIMLRDLMELARTGGDLEEPDYQCATPLHIAAANGYVRV 295
Query: 157 VSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKIC 216
V L +++ V+ DK+ W+P+ A GH +V L L + DD + IC
Sbjct: 296 VEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADL--NVRNKDDETPSDIC 353
Query: 217 VDAKVKD 223
D ++++
Sbjct: 354 EDPEIRE 360
>YPL110c_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 519
Score = 60.1 bits (144), Expect = 3e-09
Identities = 54/197 (27%), Positives = 88/197 (44%), Gaps = 19/197 (9%)
Query: 7 LHAACMNGDTEKVQQIL---------SEFP--GAVKVKDDDGRYPLHWAVSFQQDNIIDI 55
LH +C G +E + I+ +E P D + PLH V ++
Sbjct: 129 LHYSCQYGLSEVTKLIIKLMKEWNIWNEIPIDDVSAFGDAESLTPLHLCVLGAHPKTTEV 188
Query: 56 LLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN-GITALHL 114
LL LD + S +H+A+ + +L LL+ + +++ Q N T L+L
Sbjct: 189 LLQ-----SLDPNVKLKSSSLLHLATEWNNYPLLHVLLS-SKRFDINYQDNELHETPLYL 242
Query: 115 ACSKKHLNVVQLLVERGASVRIKDGL-GQLPLHRAAASGSVGIVSILCDKNSPVNIKDKN 173
AC L+ GA + I++ L G + AAA G IV +L N+ +I+D+
Sbjct: 243 ACRLNFFEAAVCLLYNGADLEIREKLFGWTAIFVAAAEGFTDIVKLLIANNANFDIEDEG 302
Query: 174 GWSPLFHALAEGHGDVA 190
GW+P+ HA+ GH +A
Sbjct: 303 GWTPMEHAVLRGHLHIA 319
>Hs4758606 [T] KOG0195 Integrin-linked kinase
Length = 452
Score = 59.7 bits (143), Expect = 3e-09
Identities = 39/140 (27%), Positives = 71/140 (49%), Gaps = 5/140 (3%)
Query: 11 CMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILD 70
C G+ V+ L + DD G PLHWA + ++++L+ +I+ +++
Sbjct: 8 CREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARIN---VMN 64
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
+P+H+A+S G I++KLL + + +++ +G LH AC V + LV
Sbjct: 65 RGDDTPLHLAASHGHRDIVQKLLQY--KADINAVNEHGNVPLHYACFWGQDQVAEDLVAN 122
Query: 131 GASVRIKDGLGQLPLHRAAA 150
GA V I + G++P+ +A A
Sbjct: 123 GALVSICNKYGEMPVDKAKA 142
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/111 (31%), Positives = 58/111 (51%), Gaps = 1/111 (0%)
Query: 84 GSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQL 143
G+ + L++T E +L+ ++G + LH AC + VV++L+ RGA + + +
Sbjct: 11 GNAVAVRLWLDNT-ENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDT 69
Query: 144 PLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
PLH AA+ G IV L + +N +++G PL +A G VA LV
Sbjct: 70 PLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV 120
Score = 51.2 bits (121), Expect = 1e-06
Identities = 35/114 (30%), Positives = 57/114 (49%), Gaps = 2/114 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D+ G+SP+H A G ++E L+ N+ + ++ T LHLA S H ++VQ L++
Sbjct: 31 DDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDD--TPLHLAASHGHRDIVQKLLQ 88
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
A + + G +PLH A G + L + V+I +K G P+ A A
Sbjct: 89 YKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKA 142
>Hs4758818 [T] KOG1217 Fibrillins and related proteins containing Ca2+-binding
EGF-like domains
Length = 2003
Score = 59.3 bits (142), Expect = 4e-09
Identities = 44/161 (27%), Positives = 76/161 (46%), Gaps = 6/161 (3%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILL-SYMKKIDLDTILDESGWSPVHIASSIGSVTILEKL 92
D GR PLH AV+ + +LL S +D T E G +P+ +A+ + ++E+L
Sbjct: 1664 DRAGRTPLHAAVAADAREVCQLLLRSRQTAVDART---EDGTTPLMLAARLAVEDLVEEL 1720
Query: 93 LNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASG 152
+ + ++ + G TALH A + + + L++ GA +D Q PL AA G
Sbjct: 1721 I--AAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1778
Query: 153 SVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTL 193
+V + +L + ++D+ G +P A H D+ L
Sbjct: 1779 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLL 1819
Score = 49.3 bits (116), Expect = 4e-06
Identities = 43/158 (27%), Positives = 69/158 (43%), Gaps = 4/158 (2%)
Query: 37 GRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHT 96
G PLH A F + LL + D +G +P+H A + + + + LL
Sbjct: 1634 GETPLHLAARFSRPTAARRLLEAGANPNQP---DRAGRTPLHAAVAADAREVCQLLLRSR 1690
Query: 97 VEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGI 156
+ +D + +G T L LA ++V+ L+ A V +D G+ LH AAA +
Sbjct: 1691 -QTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARA 1749
Query: 157 VSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
L + + +D +PLF A EG +VA L+
Sbjct: 1750 ARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLL 1787
>At5g02620 [R] KOG0504 FOG: Ankyrin repeat
Length = 517
Score = 59.3 bits (142), Expect = 4e-09
Identities = 55/231 (23%), Positives = 102/231 (43%), Gaps = 41/231 (17%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGA-----VKVKDDDGRYPLHWAVSFQQDNIIDILLS 58
D LH A G T+ + +++ E G + ++ G L+ A + +++ IL+
Sbjct: 11 DTPLHTAVREGKTDLLLEMIGEHDGVELKELLAEQNQSGETALYVAAEYGYTDMVKILMK 70
Query: 59 YMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLN-----------------HT----- 96
+ + T ++G+ HIA+ G++ +L+ L+ HT
Sbjct: 71 HSDSVLAGTKA-KNGFDAFHIAAKNGNLQVLDVLIEANPELSFTFDSSKTTALHTAASQG 129
Query: 97 --------VEPNLDLQA---NNGITALHLACSKKHLNVVQLLVERGASVRIK-DGLGQLP 144
++ +DL A +NG TALH A H +V+ L+E+ A + + D GQ
Sbjct: 130 HGEIVCFLLDKGVDLAAIARSNGKTALHSAARNGHTVIVKKLIEKKAGMVTRVDKKGQTA 189
Query: 145 LHRAAASGSVGIVSILCDKN-SPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
LH A + IV +L + + S +N D G +PL A+ + ++ T++
Sbjct: 190 LHMAVKGQNTEIVDVLMEADGSLINSADNKGNTPLHIAVRKNRAEIVQTVL 240
Score = 58.2 bits (139), Expect = 1e-08
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 5/162 (3%)
Query: 40 PLHWAVSFQQDNIIDILLSYMKKIDLDTILDE---SGWSPVHIASSIGSVTILEKLLNHT 96
PLH AV + +++ ++ ++L +L E SG + +++A+ G +++ L+ H+
Sbjct: 13 PLHTAVREGKTDLLLEMIGEHDGVELKELLAEQNQSGETALYVAAEYGYTDMVKILMKHS 72
Query: 97 VEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIK-DGLGQLPLHRAAASGSVG 155
+A NG A H+A +L V+ +L+E + D LH AA+ G
Sbjct: 73 DSVLAGTKAKNGFDAFHIAAKNGNLQVLDVLIEANPELSFTFDSSKTTALHTAASQGHGE 132
Query: 156 IVSILCDKNSPV-NIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
IV L DK + I NG + L A GH + L+ K
Sbjct: 133 IVCFLLDKGVDLAAIARSNGKTALHSAARNGHTVIVKKLIEK 174
>CE24712 [KLO] KOG1037 NAD+ ADP-ribosyltransferase Parp required for
poly-ADP ribosylation of nuclear proteins
Length = 2276
Score = 58.9 bits (141), Expect = 6e-09
Identities = 53/209 (25%), Positives = 96/209 (45%), Gaps = 23/209 (11%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A ++ T ++ + + +P + + D D Y +H+A ++ LL +
Sbjct: 350 LHTAAISNSTHMLEAMRAVYP-TINIPDQDNWYTMHYAACAPGTAPMEFLLKNGGSV--- 405
Query: 67 TILDESGWSPVHIASSIGSVT----ILEKLLN--------HTVEPN---LDLQANNGITA 111
T+L + +P+H+A+ G +++++L+ T+ + ++ + +G +A
Sbjct: 406 TMLTKQTETPLHVAARAGRAVNCTFLMKEMLDLEKGDDGESTIRADRSIINARTRSGNSA 465
Query: 112 LHLACSKKHLNVVQ-LLVERGASVRIKDGLGQ---LPLHRAAASGSVGIVSILCDKNSPV 167
LHLA + +L+VV LL E V GQ PL A G + + L +K + V
Sbjct: 466 LHLAVLRNNLDVVDALLAEPTIVVDNPTSTGQNRLTPLMMACGKGYLEMAKKLVEKGALV 525
Query: 168 NIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
KDK +PL HA+ G A L+ K
Sbjct: 526 EGKDKKKRTPLIHAMLNGQIHTAAFLLAK 554
Score = 53.1 bits (126), Expect = 3e-07
Identities = 36/119 (30%), Positives = 59/119 (49%), Gaps = 2/119 (1%)
Query: 72 SGWSPVHIASSIGSVTILEKLLNHT--VEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
SG S +H+A ++ +++ LL V N N +T L +AC K +L + + LVE
Sbjct: 461 SGNSALHLAVLRNNLDVVDALLAEPTIVVDNPTSTGQNRLTPLMMACGKGYLEMAKKLVE 520
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGD 188
+GA V KD + PL A +G + + L K + + + D +G + +A A G D
Sbjct: 521 KGALVEGKDKKKRTPLIHAMLNGQIHTAAFLLAKGASLTLADSSGNTAAHYAAAYGFLD 579
>CE05185 [R] KOG0504 FOG: Ankyrin repeat
Length = 682
Score = 58.9 bits (141), Expect = 6e-09
Identities = 46/154 (29%), Positives = 69/154 (43%), Gaps = 6/154 (3%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
A NGD +K+ +L + + DDD LH A + + ++ LL Y I +
Sbjct: 22 AAFNGDIDKIDGLLRDKKVHIDSVDDDQVTALHIAAAMGNNKLVVRLLDYGANIH---AV 78
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
+ G + H A+ G + +L+ L+ N G+TAL LAC+ H +VV+ L+
Sbjct: 79 NHLGMTAYHYAAREGKLAVLDTLMQRGASKNQTTAL--GVTALTLACAGGHADVVRRLIR 136
Query: 130 -RGASVRIKDGLGQLPLHRAAASGSVGIVSILCD 162
+ R K L PL A S S I S L D
Sbjct: 137 ISNETPRSKQSLAPTPLIVATCSKSPQICSYLAD 170
>Hs11968152_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 654
Score = 58.9 bits (141), Expect = 6e-09
Identities = 37/118 (31%), Positives = 58/118 (48%), Gaps = 4/118 (3%)
Query: 71 ESGWSPVHIASSI-GSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
+SG +P+ +A+ GSV ++ L ++D +A +G+TALH A +H + L++
Sbjct: 211 DSGETPLTLAAQTEGSVEVIRTLCLGGA--HIDFRARDGMTALHKAACARHCLALTALLD 268
Query: 130 RGASVRIKDGLGQLPL-HRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
G S KD G PL H A G +L + + I D+NGW + A GH
Sbjct: 269 LGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGH 326
Score = 52.8 bits (125), Expect = 4e-07
Identities = 41/132 (31%), Positives = 60/132 (45%), Gaps = 6/132 (4%)
Query: 23 LSEFPGAVKVKDDDGRYPL-HWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIAS 81
L + G+ KD G PL H A+ ++LL ++ I DE+GW +H A
Sbjct: 266 LLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLG---IADENGWQEIHQAC 322
Query: 82 SIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLG 141
G LE LL + EP Q +G TALH+ ++L+ RGA +K+ G
Sbjct: 323 QRGHSQHLEHLLFYGAEPG--AQNASGNTALHICALYNKETCARILLYRGADKDVKNNNG 380
Query: 142 QLPLHRAAASGS 153
Q P A +G+
Sbjct: 381 QTPFQVAVIAGN 392
>Hs4505317 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 1030
Score = 58.5 bits (140), Expect = 7e-09
Identities = 61/222 (27%), Positives = 94/222 (41%), Gaps = 37/222 (16%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
GA FL AAC +GDT++V ++L GA + + DG LH A +++ L+
Sbjct: 41 GAVFL--AACSSGDTDEVLKLLHR--GADINYANVDGLTALHQACIDDNVDMVKFLVENG 96
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKH 120
I+ D GW P+H A+S G + I E L+ ++ + G T L +A +
Sbjct: 97 ANINQP---DNEGWIPLHAAASCGYLDIAEFLIGQGA--HVGAVNSEGDTPLDIAEEEAM 151
Query: 121 LNVVQLLVERGA-----------SVRIKDGL----------------GQLPLHRAAASGS 153
++Q V R + ++D G LH AAA G
Sbjct: 152 EELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGY 211
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
++ +L VNIKD +GW+PL A G + LV+
Sbjct: 212 TEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVD 253
Score = 58.2 bits (139), Expect = 1e-08
Identities = 40/118 (33%), Positives = 62/118 (51%), Gaps = 4/118 (3%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQAN-NGITALHLACSKKHLNVVQLLVERGASVRIKD 138
A S G + KLL+ + N AN +G+TALH AC ++++V+ LVE GA++ D
Sbjct: 47 ACSSGDTDEVLKLLHRGADINY---ANVDGLTALHQACIDDNVDMVKFLVENGANINQPD 103
Query: 139 GLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
G +PLH AA+ G + I L + + V + G +PL A E ++ VN+
Sbjct: 104 NEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNR 161
>Hs13631463 [R] KOG0504 FOG: Ankyrin repeat
Length = 201
Score = 58.5 bits (140), Expect = 7e-09
Identities = 47/154 (30%), Positives = 77/154 (49%), Gaps = 6/154 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC NG T+ V L E + V+D + + PL AV Q ++ ILL++ DL
Sbjct: 10 LHLACANGHTDVVL-FLIEQQCKINVRDSENKSPLIKAVQCQNEDCATILLNFGADPDLR 68
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
I + +H A S++++EKLL + E +L+ + +G T L +A + +V+
Sbjct: 69 DIRYN---TVLHYAVCGQSLSLVEKLLEY--EADLEAKNKDGYTPLLVAVINNNPKMVKF 123
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
L+E+GA V D + L A + +V +L
Sbjct: 124 LLEKGADVNASDNYQRTALILAVSGEPPCLVKLL 157
>Hs12746412 [R] KOG0502 Integral membrane ankyrin-repeat protein Kidins220
(protein kinase D substrate)
Length = 313
Score = 58.2 bits (139), Expect = 1e-08
Identities = 41/149 (27%), Positives = 74/149 (49%), Gaps = 15/149 (10%)
Query: 41 LHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN 100
L+ A +Q+N+I+ DE G++P+ A++ G + ++E LL + +P
Sbjct: 163 LYLATRIEQENVINHT-------------DEEGFTPLMWAAAHGQIAVVEFLLQNGADP- 208
Query: 101 LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
L +AL LACSK + ++V++L++ G V D G PL A V V +L
Sbjct: 209 -QLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKML 267
Query: 161 CDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
+ + I+ +G++ + A+A G+ V
Sbjct: 268 LESGADPTIETDSGYNSMDLAVALGYRSV 296
>At4g27780 [I] KOG0817 Acyl-CoA-binding protein
Length = 354
Score = 58.2 bits (139), Expect = 1e-08
Identities = 34/92 (36%), Positives = 50/92 (53%), Gaps = 3/92 (3%)
Query: 89 LEKLLNHTVEPNLDLQANN--GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLH 146
+E LL ++E + + A + G T LH A + HLN+ ++LV++ A V KD GQ PLH
Sbjct: 246 VENLLK-SIESGIPVNARDSEGRTPLHWAIDRGHLNIAKVLVDKNADVNAKDNEGQTPLH 304
Query: 147 RAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
A I L +N+ KD++G SPL
Sbjct: 305 YAVVCDREAIAEFLVKQNANTAAKDEDGNSPL 336
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/88 (32%), Positives = 44/88 (49%)
Query: 109 ITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN 168
I A+H + + + +E G V +D G+ PLH A G + I +L DKN+ VN
Sbjct: 234 IDAIHGFAREGEVENLLKSIESGIPVNARDSEGRTPLHWAIDRGHLNIAKVLVDKNADVN 293
Query: 169 IKDKNGWSPLFHALAEGHGDVAVTLVNK 196
KD G +PL +A+ +A LV +
Sbjct: 294 AKDNEGQTPLHYAVVCDREAIAEFLVKQ 321
>At1g07710 [R] KOG0504 FOG: Ankyrin repeat
Length = 543
Score = 58.2 bits (139), Expect = 1e-08
Identities = 44/160 (27%), Positives = 84/160 (52%), Gaps = 7/160 (4%)
Query: 41 LHWAVSF-QQDNIIDILLSYMKKIDLDTIL---DESGWSPVHIASSIGSVTILEKLLNHT 96
LH AV +D +++IL ++ +L+ +L ++SG + +++A+ G V I+++++N
Sbjct: 31 LHSAVRHGNKDRVVEILTK-TRESELNQLLGKQNQSGETALYVAAEYGDVEIVKEMINCY 89
Query: 97 VEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQ-LPLHRAAASGSVG 155
++++A NG A H+A + L+V+++L E + + + L LH AA G
Sbjct: 90 DLALVEIKARNGFDAFHIAAKQGDLDVLKVLAEAHSELAMTVDLSNTTALHTAATQGHTE 149
Query: 156 IVSILCDKNSPV-NIKDKNGWSPLFHALAEGHGDVAVTLV 194
+V+ L + S + I NG + L A GH V L+
Sbjct: 150 VVNFLLELGSSLAGIAKSNGKTALHSASRNGHVKVIKALL 189
Score = 53.9 bits (128), Expect = 2e-07
Identities = 49/191 (25%), Positives = 90/191 (46%), Gaps = 6/191 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
L+ A GD E V+++++ + A V++K +G H A +++ +L ++ +
Sbjct: 70 LYVAAEYGDVEIVKEMINCYDLALVEIKARNGFDAFHIAAKQGDLDVLKVLAEAHSELAM 129
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
+D S + +H A++ G ++ LL + +NG TALH A H+ V++
Sbjct: 130 T--VDLSNTTALHTAATQGHTEVVNFLLE-LGSSLAGIAKSNGKTALHSASRNGHVKVIK 186
Query: 126 LLVERGASVRIK-DGLGQLPLHRAAASGSVGIVSILCDKN-SPVNIKDKNGWSPLFHALA 183
L+ ++ I+ D GQ LH A +V +V L + S +NI D G + L A
Sbjct: 187 ALLASEPAIAIRMDKKGQTALHMAVKGTNVEVVEELIKADRSSINIADTKGNTALHIAAR 246
Query: 184 EGHGDVAVTLV 194
+G + L+
Sbjct: 247 KGRSQIVKLLL 257
>Hs10092619 [R] KOG0504 FOG: Ankyrin repeat
Length = 317
Score = 57.8 bits (138), Expect = 1e-08
Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 11/182 (6%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGAV---KVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
D LH A ++ + +++ + G + +++ + PLH AV Q I + LL
Sbjct: 75 DSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAG 134
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLD--LQANN--GITALHLAC 116
+L D G +P+H+A G + + L P+L L+A N G T LHLA
Sbjct: 135 CDPELR---DFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLAS 191
Query: 117 SKKHLNVVQLLVERGASVRIKDGL-GQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGW 175
+L +V+LLV GA V ++ G+ LH A + +VS+L + VN G+
Sbjct: 192 IHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGY 251
Query: 176 SP 177
SP
Sbjct: 252 SP 253
>CE27723 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 850
Score = 57.8 bits (138), Expect = 1e-08
Identities = 60/217 (27%), Positives = 95/217 (43%), Gaps = 39/217 (17%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A M GD+E + +L+ GA + V D LH A F Q+N + L+S ++L
Sbjct: 154 LHLAAMIGDSEMLTILLNS--GANIHVTDFVHFTALHCATYFGQENAVRTLISASANLNL 211
Query: 66 -----------------------------DTIL-DESGWSPVHIASSIGSVTILEKLLNH 95
D +L D+ G +H A+ GS+ IL L+
Sbjct: 212 GGAVNDRPIHLAAAKGLTSITKLLLEAKADPLLADDEGNQALHYAAKSGSLVILNMLIKQ 271
Query: 96 TVEPNLDLQANN--GITALHLACSKKHLNVVQLLVERGAS--VRIKDGLGQLPLHRAAAS 151
N + A N G TALHL+C L++V+ +++ + V +++ + PLH A
Sbjct: 272 VRGTNDRICARNLYGDTALHLSCYSGRLDIVKSILDSSPTNIVNMENVFSETPLHAACTG 331
Query: 152 G-SVGIVSILCD-KNSPVNIKDKNGWSPLFHALAEGH 186
G S+ +VS L N + ++G + L A GH
Sbjct: 332 GKSIELVSFLMKYPGVDPNYQGQDGHTALHSACYHGH 368
Score = 54.3 bits (129), Expect = 1e-07
Identities = 52/191 (27%), Positives = 82/191 (42%), Gaps = 18/191 (9%)
Query: 6 LLHAACM---NGDTEKVQQILSEFPGAVKV-----KDDDGRYPLHWAVSFQQDNIIDILL 57
L H C + EK+Q ++ P + + +G PLH A+ ++ D I L
Sbjct: 77 LFHIICAGHSDSQPEKLQFLIDNLPKESSITLISSQSANGFTPLHIAI-YRGDVAILKAL 135
Query: 58 SYMKKIDLDTILDESG---WSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHL 114
K +DLD +SG +H+A+ IG +L LLN N+ + TALH
Sbjct: 136 IATKLVDLD----QSGRHLLPALHLAAMIGDSEMLTILLNSGA--NIHVTDFVHFTALHC 189
Query: 115 ACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
A N V+ L+ A++ + + P+H AAA G I +L + + + D G
Sbjct: 190 ATYFGQENAVRTLISASANLNLGGAVNDRPIHLAAAKGLTSITKLLLEAKADPLLADDEG 249
Query: 175 WSPLFHALAEG 185
L +A G
Sbjct: 250 NQALHYAAKSG 260
Score = 48.9 bits (115), Expect = 6e-06
Identities = 45/159 (28%), Positives = 75/159 (46%), Gaps = 15/159 (9%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDD--GRY---PLHWAVSFQQDNIIDILLSYMK 61
LH A GD ++ ++ A K+ D D GR+ LH A ++ ILL+
Sbjct: 120 LHIAIYRGDVAILKALI-----ATKLVDLDQSGRHLLPALHLAAMIGDSEMLTILLNSGA 174
Query: 62 KIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHL 121
I + D ++ +H A+ G + L++ + NL N+ +HLA +K
Sbjct: 175 NIH---VTDFVHFTALHCATYFGQENAVRTLISASANLNLGGAVND--RPIHLAAAKGLT 229
Query: 122 NVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
++ +LL+E A + D G LH AA SGS+ I+++L
Sbjct: 230 SITKLLLEAKADPLLADDEGNQALHYAAKSGSLVILNML 268
>At5g61230 [R] KOG0504 FOG: Ankyrin repeat
Length = 174
Score = 57.8 bits (138), Expect = 1e-08
Identities = 33/101 (32%), Positives = 55/101 (53%), Gaps = 4/101 (3%)
Query: 69 LDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQA--NNGITALHLACSKKHLNVVQL 126
+D+ GW+P+HI + G + +++LL+ ++ N + G++ALHLA H+ V+ L
Sbjct: 25 VDDRGWNPLHIKARKGDLKSVKQLLDQGMDVNALAWGPKSKGVSALHLAAEGGHIEVMDL 84
Query: 127 LVERGASVRIK--DGLGQLPLHRAAASGSVGIVSILCDKNS 165
L+ERGA++ K G PLH AA V L + +
Sbjct: 85 LLERGANIDAKTWGSCGWTPLHAAAKERKREAVKFLVENGA 125
>At2g26650 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 857
Score = 57.8 bits (138), Expect = 1e-08
Identities = 46/177 (25%), Positives = 76/177 (41%), Gaps = 34/177 (19%)
Query: 54 DILLSYMKKIDLD-TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITAL 112
D+LL + K LD D +G +P+HIA+S G++ + LL + +PN + G L
Sbjct: 531 DLLLHQLLKRGLDPNESDNNGRTPLHIAASKGTLNCVLLLLEYHADPNC--RDAEGSVPL 588
Query: 113 HLACSKKHLNVVQLLVERGASVRIKD-------------------------------GLG 141
A + H VV++L+E G+++ D G
Sbjct: 589 WEAMVEGHEKVVKVLLEHGSTIDAGDVGHFACTAAEQGNLKLLKEIVLHGGDVTRPRATG 648
Query: 142 QLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYH 198
LH A ++ +V L ++ + VN +D +GW+P A +GH D+ K H
Sbjct: 649 TSALHTAVCEENIEMVKYLLEQGADVNKQDMHGWTPRDLAEQQGHEDIKALFREKLH 705
Score = 48.9 bits (115), Expect = 6e-06
Identities = 31/107 (28%), Positives = 53/107 (48%), Gaps = 5/107 (4%)
Query: 88 ILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHR 147
+L ++ N +DL N L A ++ ++ L++RG D G+ PLH
Sbjct: 503 VLLEIENMLARGKMDLPLN-----LCFAAIREDDLLLHQLLKRGLDPNESDNNGRTPLHI 557
Query: 148 AAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
AA+ G++ V +L + ++ N +D G PL+ A+ EGH V L+
Sbjct: 558 AASKGTLNCVLLLLEYHADPNCRDAEGSVPLWEAMVEGHEKVVKVLL 604
>7301236 [T] KOG0507 CASK-interacting adaptor protein (caskin) and related
proteins with ankyrin repeats and SAM domain
Length = 863
Score = 57.8 bits (138), Expect = 1e-08
Identities = 41/131 (31%), Positives = 62/131 (47%), Gaps = 16/131 (12%)
Query: 80 ASSIGSVTILEKLLNHTVE-----------PNLDLQANNGITALHLACSKKHLNVVQLLV 128
AS G + ++KLL H+ + P+++ Q NG T+LH AC H N+V+LL+
Sbjct: 10 ASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNGYTSLHHACLNGHSNIVRLLL 69
Query: 129 ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV----NIKDKNGWSPLFHALAE 184
A + + D G PL AA +G IV +L +SP N + +PL
Sbjct: 70 SHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLL-MHSPTGANPNAQTIENETPLHSGAQH 128
Query: 185 GHGDVAVTLVN 195
GH V L++
Sbjct: 129 GHNAVVAILLS 139
Score = 50.4 bits (119), Expect = 2e-06
Identities = 50/173 (28%), Positives = 76/173 (43%), Gaps = 16/173 (9%)
Query: 1 MGADFLLHAACMNGDTEKVQQIL----------SEF--PGAVKVKDDDGRYPLHWAVSFQ 48
MG D L A GD + V ++L S F ++ +D +G LH A
Sbjct: 1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNGYTSLHHACLNG 60
Query: 49 QDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHT-VEPNLDLQANN 107
NI+ +LLS+ +D + D G +P+ +A+ G I++ LL H+ N + Q
Sbjct: 61 HSNIVRLLLSHNALLD---VPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIE 117
Query: 108 GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
T LH H VV +L+ GA I++ Q L AA G + +V L
Sbjct: 118 NETPLHSGAQHGHNAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTL 170
>7293339 [R] KOG0504 FOG: Ankyrin repeat
Length = 1409
Score = 57.8 bits (138), Expect = 1e-08
Identities = 35/121 (28%), Positives = 68/121 (55%), Gaps = 2/121 (1%)
Query: 77 VHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV-ERGASVR 135
+H A++ G + ++ L+ +V+ + Q +N +T ++LA + HL V++ LV E G S+
Sbjct: 20 LHYAAARGCLDCVQLLVAASVDICANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAGGSLY 79
Query: 136 IKDGLGQLPLHRAAASGSVGIVS-ILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
++ G P+H A+ G + + ++ D+ N++D +G +PL A + GH V L+
Sbjct: 80 VRARDGMAPIHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLL 139
Query: 195 N 195
N
Sbjct: 140 N 140
Score = 55.1 bits (131), Expect = 8e-08
Identities = 33/102 (32%), Positives = 60/102 (58%), Gaps = 4/102 (3%)
Query: 73 GWSPVHIASSIGSVTILEKLL-NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERG 131
G +P+H AS +G + L+ ++ + V+PNL + +G T LH A S+ HL+VV+ L+ G
Sbjct: 85 GMAPIHAASQMGCLDCLKWMVQDQGVDPNL--RDGDGATPLHFAASRGHLSVVRWLLNHG 142
Query: 132 ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKN 173
A + + D G+ P++ AA + V +++L + V+ K+
Sbjct: 143 AKLSL-DKYGKSPINDAAENQQVECLNVLVQHGTSVDYNGKS 183
Score = 49.7 bits (117), Expect = 3e-06
Identities = 36/129 (27%), Positives = 67/129 (51%), Gaps = 7/129 (5%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
++ A G E ++ ++ E G++ V+ DG P+H A Q +D L ++ +D
Sbjct: 55 VYLAAQEGHLEVLKFLVLEAGGSLYVRARDGMAPIHAA---SQMGCLDCLKWMVQDQGVD 111
Query: 67 TIL-DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
L D G +P+H A+S G ++++ LLNH + +LD G + ++ A + + +
Sbjct: 112 PNLRDGDGATPLHFAASRGHLSVVRWLLNHGAKLSLD---KYGKSPINDAAENQQVECLN 168
Query: 126 LLVERGASV 134
+LV+ G SV
Sbjct: 169 VLVQHGTSV 177
>Hs4557349_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 162
Score = 57.8 bits (138), Expect = 1e-08
Identities = 39/106 (36%), Positives = 55/106 (51%), Gaps = 2/106 (1%)
Query: 73 GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGA 132
G + +HIAS G + +E LL + +PN+ A G T LH AC+ HL VV+LL++ A
Sbjct: 19 GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHA--GWTPLHEACNHGHLKVVELLLQHKA 76
Query: 133 SVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
V PLH AA +G V IV +L + N + G P+
Sbjct: 77 LVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPV 122
Score = 56.2 bits (134), Expect = 4e-08
Identities = 32/98 (32%), Positives = 50/98 (50%), Gaps = 1/98 (1%)
Query: 99 PNLDLQANN-GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIV 157
PN+ ++ N+ G T LH+A K + V+ L++ G+ +KD G PLH A G + +V
Sbjct: 9 PNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVV 68
Query: 158 SILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
+L + VN SPL A GH D+ L++
Sbjct: 69 ELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLS 106
>Hs7656961 [R] KOG0504 FOG: Ankyrin repeat
Length = 319
Score = 57.4 bits (137), Expect = 2e-08
Identities = 32/107 (29%), Positives = 60/107 (55%), Gaps = 2/107 (1%)
Query: 88 ILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHR 147
++EK L+ P++ + TALH AC + HL +V+ L+E GA + +D L +H
Sbjct: 135 VVEKFLSDKNNPDVCDEYKR--TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHW 192
Query: 148 AAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
A+ G++ ++ +L +K + ++ +DK + L A+ GH + A L+
Sbjct: 193 ASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLI 239
Score = 50.1 bits (118), Expect = 3e-06
Identities = 34/133 (25%), Positives = 66/133 (49%), Gaps = 2/133 (1%)
Query: 50 DNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI 109
+N + ++ ++ + + DE + +H A G + I+EKL+ + ++ +
Sbjct: 130 ENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQ--IEFRDMLES 187
Query: 110 TALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNI 169
TA+H A +L+V++LL+ +GA + +D L LH A +G L + +N
Sbjct: 188 TAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNA 247
Query: 170 KDKNGWSPLFHAL 182
KD+ G +PL A+
Sbjct: 248 KDREGDTPLHDAV 260
>CE16688 [R] KOG0504 FOG: Ankyrin repeat
Length = 633
Score = 57.4 bits (137), Expect = 2e-08
Identities = 60/193 (31%), Positives = 86/193 (44%), Gaps = 23/193 (11%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKV-------KDDDGRYPLHWAVSFQQDNIIDILLSY 59
LH A DT K+ +I E KV KD R PLH+A + ILL
Sbjct: 135 LHIAATKQDT-KILKIFVEILKTPKVMELFSIVKDKRDRSPLHYAACKVNLEALRILLFV 193
Query: 60 MKKIDLD---TI--LDESGWSP------VHIASSIGSVTILEKLLNHTVEPNLDLQANNG 108
D T+ D+ G P V++ +I + LEK + Q +G
Sbjct: 194 DPNGGPDFGFTVDQRDKFGIIPLMCAVGVNLPQAIPVIRFLEK----KKPVSKTRQNRDG 249
Query: 109 ITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN 168
+TALH+A + ++L VQLL+E G+SV + D + PLH AA G IV L + +
Sbjct: 250 MTALHIAVAARNLEAVQLLIELGSSVDLVDNEQRTPLHYAAEQGYPEIVKFLLCNGARNS 309
Query: 169 IKDKNGWSPLFHA 181
+D G +P +A
Sbjct: 310 TRDHIGATPAHYA 322
Score = 55.8 bits (133), Expect = 5e-08
Identities = 47/180 (26%), Positives = 85/180 (47%), Gaps = 18/180 (10%)
Query: 31 KVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILE 90
+V D++GR L WAV +I+ L+ + D++G++ +H+A+ +G + +
Sbjct: 341 EVNDNEGRSCLMWAVCAGNIEVINYLIQ-REDAPKRAACDKNGYTALHLAAMVGHEKVCK 399
Query: 91 KLLNH--TVEP-----NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQL 143
L N ++ P +L + N+ TALHLA + H +V++ LV GA++ D +G+
Sbjct: 400 ILTNQPTSIFPYFQGWSLSERDNHSNTALHLASGRGHTDVLRCLVASGANMNDVDEVGRT 459
Query: 144 PLHRAAASGSVGIVSILCDK-------NSPVNIK---DKNGWSPLFHALAEGHGDVAVTL 193
+ A G + + + + VN + DKNG + L A E + V L
Sbjct: 460 AVFWACMGGQAHTLHCMIKELGFEWRTSGSVNTRPKCDKNGRTALHAAAVESSACINVLL 519
Score = 52.4 bits (124), Expect = 5e-07
Identities = 47/176 (26%), Positives = 80/176 (44%), Gaps = 4/176 (2%)
Query: 25 EFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD-TILDESGWSPVHIASSI 83
+F V +D G PL AV I ++ KK + T + G + +HIA +
Sbjct: 200 DFGFTVDQRDKFGIIPLMCAVGVNLPQAIPVIRFLEKKKPVSKTRQNRDGMTALHIAVAA 259
Query: 84 GSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQL 143
++ ++ L+ + ++DL N T LH A + + +V+ L+ GA +D +G
Sbjct: 260 RNLEAVQLLIE--LGSSVDLVDNEQRTPLHYAAEQGYPEIVKFLLCNGARNSTRDHIGAT 317
Query: 144 PLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHA 199
P H AA SV + IL ++ + D G S L A+ G+ +V L+ + A
Sbjct: 318 PAH-YAAQFSVECLKILFAESKITEVNDNEGRSCLMWAVCAGNIEVINYLIQREDA 372
>7298294 [R] KOG0504 FOG: Ankyrin repeat
Length = 500
Score = 57.4 bits (137), Expect = 2e-08
Identities = 46/198 (23%), Positives = 90/198 (45%), Gaps = 34/198 (17%)
Query: 4 DFLLHAACMNGDTEKVQQIL--SEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMK 61
D LH AC++G + V ++ + P + +++D + PLH A Q NI+ ILL
Sbjct: 231 DTPLHLACISGSVDVVAALIRMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGA 290
Query: 62 KIDLDTILDESGWSPVHIASSIGSVTILEKL---------------------------LN 94
+ T+ D G + +H++ G + L L+
Sbjct: 291 E---PTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLS 347
Query: 95 HTVEP-NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG-LGQLPLHRAAASG 152
+ P +L+++ +G +HLA H++++++LV GA + ++G G+ PLH A
Sbjct: 348 YACLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGC 407
Query: 153 SVGIVSILCDKNSPVNIK 170
+ + + L D+ +N++
Sbjct: 408 NEDLANFLLDECEKLNLE 425
>7295029 [R] KOG0510 Ankyrin repeat protein
Length = 1274
Score = 57.4 bits (137), Expect = 2e-08
Identities = 58/249 (23%), Positives = 92/249 (36%), Gaps = 43/249 (17%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKV----KDDDGRYPLHWAVSFQQDNIIDILLSYMKK 62
+H AC G + V+ + P ++ D PLH A F +I+ L++
Sbjct: 323 VHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGAD 382
Query: 63 ID---------LDTILDESGWSPVHIASSIGS-----------------------VTILE 90
I+ L SGW VH+ +G+ E
Sbjct: 383 INALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAE 442
Query: 91 KLLNHTVEPNLDLQANN----GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLH 146
++ N + L L N G + LH A H+ ++ L+ GA + +K+ + PLH
Sbjct: 443 QVANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLH 502
Query: 147 RAAASGSVGIVSILCDKNSP---VNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEG 203
AA G V L D +N D G +PL + +GH V L+N+ L
Sbjct: 503 FAARYGRYNTVRQLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRD 562
Query: 204 ETDNDDLSI 212
T + L +
Sbjct: 563 HTGRNPLQL 571
Score = 56.6 bits (135), Expect = 3e-08
Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 6/141 (4%)
Query: 28 GAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDT-ILDESGWSPVHIASSIGSV 86
G KD+ G PLH AV + +D LLS I +DT +L+E +PVH+A+ + V
Sbjct: 114 GDFNAKDNAGNTPLHIAVESDAYDALDYLLS----IPVDTGVLNEKKQAPVHLATELNKV 169
Query: 87 TILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV-ERGASVRIKDGLGQLPL 145
L + + ++ +G TALHLA H ++L+ E A R G P+
Sbjct: 170 KSLRVMGQYRNVIDIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCNNGYYPI 229
Query: 146 HRAAASGSVGIVSILCDKNSP 166
H AA + S + + + P
Sbjct: 230 HEAAKNASSKTMEVFFQASYP 250
>Hs22062923 [R] KOG0504 FOG: Ankyrin repeat
Length = 794
Score = 57.0 bits (136), Expect = 2e-08
Identities = 55/165 (33%), Positives = 78/165 (46%), Gaps = 8/165 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G E VQ +L EF V +D +GR P+H A+S Q II +L+S+ I L+
Sbjct: 399 LHLAASWGLEETVQCLL-EFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSH-PDIHLN 456
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN-GITALHLACSKKHLNVVQ 125
+ D G +P A + + E +L E Q +N G LH+A + V
Sbjct: 457 -VRDRQGLTPFACAMTFKNNKSAEAILKR--ESGAAEQVDNKGRNFLHVAVQNSDIESVL 513
Query: 126 LLVERGASV--RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN 168
L+ A+V R++D PLH A +GS IV L + VN
Sbjct: 514 FLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVN 558
Score = 55.1 bits (131), Expect = 8e-08
Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 13/203 (6%)
Query: 3 ADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDG-RYPLHWAVSFQQDNIIDILLSY-- 59
A+ L A N TE+ + E + D + PLH A+++ +++ ++L
Sbjct: 133 AELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKA 192
Query: 60 --------MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
++ I ++ D + + +A G TI +LL N + ++G T
Sbjct: 193 NALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTM--SDGQTL 250
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A ++ L+E A + ++ G+ L A + +V +C + + +++ D
Sbjct: 251 LHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPD 310
Query: 172 KNGWSPLFHALAEGHGDVAVTLV 194
+ G PL+ ALA D+A TLV
Sbjct: 311 EKGNPPLWLALANNLEDIASTLV 333
Score = 51.6 bits (122), Expect = 9e-07
Identities = 47/187 (25%), Positives = 92/187 (49%), Gaps = 14/187 (7%)
Query: 3 ADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKK 62
A FL+ + C D +Q + G + +D G+ PLH A S+ + + LL +
Sbjct: 366 ACFLIRSGC---DVNSPRQPGANGEGEEEARD--GQTPLHLAASWGLEETVQCLLEFGAN 420
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
++ D G +P+H+A S I++ L++H + +L+++ G+T A + K+
Sbjct: 421 VNAQ---DAEGRTPIHVAISSQHGVIIQLLVSHP-DIHLNVRDRQGLTPFACAMTFKNNK 476
Query: 123 VVQLLVER--GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN--IKDKNGWSPL 178
+ +++R GA+ ++ D G+ LH A + + V L ++ VN ++D + +PL
Sbjct: 477 SAEAILKRESGAAEQV-DNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPL 535
Query: 179 FHALAEG 185
A+ G
Sbjct: 536 HLAVQAG 542
Score = 49.7 bits (117), Expect = 3e-06
Identities = 41/146 (28%), Positives = 65/146 (44%), Gaps = 3/146 (2%)
Query: 15 DTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGW 74
+ + + IL GA + D+ GR LH AV + L+S ++ + D S
Sbjct: 474 NNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVN-SRVQDASKL 532
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
+P+H+A GS I+ LL + N +L + TALHLA + + +L+E G
Sbjct: 533 TPLHLAVQAGSEIIVRNLLLAGAKVN-ELTKHRQ-TALHLAAQQDLPTICSVLLENGVDF 590
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSIL 160
D G LH A G + + +L
Sbjct: 591 AAVDENGNNALHLAVMHGRLNNIRVL 616
Score = 49.7 bits (117), Expect = 3e-06
Identities = 58/213 (27%), Positives = 89/213 (41%), Gaps = 14/213 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A N D E V ++S +V+D PLH AV + I+ LL K++
Sbjct: 500 LHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNE 559
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
L + + +H+A+ TI LL + V+ NG ALHLA LN ++
Sbjct: 560 ---LTKHRQTALHLAAQQDLPTICSVLLENGVD--FAAVDENGNNALHLAVMHGRLNNIR 614
Query: 126 -LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL-----CDKNSPVNIKDKNGWSPLF 179
LL E + GQ PLH G +I C P++ D +G + L
Sbjct: 615 VLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLL 674
Query: 180 HALAEGHGDVAVTLVNKYHALWEGETDNDDLSI 212
A +G+ ++ +V L G +N ++I
Sbjct: 675 LAYMKGNANLCRAIVRSGARL--GVNNNQGVNI 705
>CE21005 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 783
Score = 57.0 bits (136), Expect = 2e-08
Identities = 41/131 (31%), Positives = 62/131 (47%), Gaps = 2/131 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D G +H A+ + I++ LL+H + NL + N T LH AC V LV+
Sbjct: 175 DHEGCGLLHWAAINNKLDIIQLLLSHRADINL-IGGNMKSTPLHWACYNSQFGAVMALVK 233
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV-NIKDKNGWSPLFHALAEGHGD 188
GA IK+ G+ PLH AA +G+ I++ L K + + +D G S L A + G
Sbjct: 234 NGADPTIKNINGETPLHLAACTGNFIIIAYLLVKFDNIKDTRDNLGRSALMMAADKSFGL 293
Query: 189 VAVTLVNKYHA 199
+ + K A
Sbjct: 294 FPIRIFTKVDA 304
>CE19676 [R] KOG0504 FOG: Ankyrin repeat
Length = 597
Score = 57.0 bits (136), Expect = 2e-08
Identities = 47/192 (24%), Positives = 88/192 (45%), Gaps = 12/192 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILL--SYMKKI 63
LH A GD + V +++ GA + + D+ G LH+ ++I +L S ++
Sbjct: 217 LHVAIRTGDPDAVHYLMNH--GAKIDISDNHGSTALHYLGDAYNESIFKEILEPSRGQRF 274
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
D++ L+ G++P+H+A ++++E L+ + L AL A
Sbjct: 275 DVNQ-LNSEGFAPIHVAVRRLKLSLIEMLIEAGALIDF-LDTEKKRNALMHAIEMNDFET 332
Query: 124 VQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
+QLLVERG+ I+D G+ L A + + ++ +L D + N ++ G LA
Sbjct: 333 IQLLVERGSGTNIEDESGETALSLAVKNVNYPVIGLLLDNGADPNRQNSKG-----ICLA 387
Query: 184 EGHGDVAVTLVN 195
+ V ++N
Sbjct: 388 DSEDSVIQNIIN 399
Score = 55.8 bits (133), Expect = 5e-08
Identities = 43/181 (23%), Positives = 85/181 (46%), Gaps = 11/181 (6%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVK-----VKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
+ H A NG + ++ +LS P +K V++ G LH A+ + + L+++
Sbjct: 177 VFHVAAKNGQSFSLKLLLSVIPPDIKNEVINVQNTHGLTALHVAIRTGDPDAVHYLMNHG 236
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN--GITALHLACSK 118
KID I D G + +H + +I +++L + D+ N G +H+A +
Sbjct: 237 AKID---ISDNHGSTALHYLGDAYNESIFKEILEPSRGQRFDVNQLNSEGFAPIHVAVRR 293
Query: 119 KHLNVVQLLVERGASVRIKD-GLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSP 177
L+++++L+E GA + D + L A + +L ++ S NI+D++G +
Sbjct: 294 LKLSLIEMLIEAGALIDFLDTEKKRNALMHAIEMNDFETIQLLVERGSGTNIEDESGETA 353
Query: 178 L 178
L
Sbjct: 354 L 354
>Hs9506623 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 481
Score = 56.6 bits (135), Expect = 3e-08
Identities = 51/179 (28%), Positives = 88/179 (48%), Gaps = 7/179 (3%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LLH A +N + V+ +S+ ++ D PLHWA+ +Q ++ ++L D
Sbjct: 85 LLHWAAINNRLDLVRFYISKGAVVDQLGGDLNSTPLHWAI--RQGHLPMVILLLQHGAD- 141
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKK-HLNVV 124
T++D G+S +H+A + I+ L++ N+ NG T L L+ K
Sbjct: 142 PTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMT--DVNGQTPLMLSAHKVIGPEPT 199
Query: 125 QLLVERGASVRIKDGLGQ-LPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
L++ S+ + D + Q PLH A A+G+V V L + S ++I++ G +PL AL
Sbjct: 200 GFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMAL 258
Score = 55.1 bits (131), Expect = 8e-08
Identities = 47/166 (28%), Positives = 80/166 (47%), Gaps = 20/166 (12%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGW----SPVHIASSIGS 85
V+ D + LHWA +N +D++ Y+ K ++D+ G +P+H A G
Sbjct: 75 VRQPDKENVSLLHWAAI---NNRLDLVRFYISK---GAVVDQLGGDLNSTPLHWAIRQGH 128
Query: 86 VTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPL 145
+ ++ LL H +P L G +++HLA +H+ ++ L+ +G SV + D GQ PL
Sbjct: 129 LPMVILLLQHGADPTLI--DGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPL 186
Query: 146 ----HRAAASGSVGIVSILCDKNSPVNIKDK-NGWSPLFHALAEGH 186
H+ G L N +N+ DK + +PL A+A G+
Sbjct: 187 MLSAHKVIGPEPTG---FLLKFNPSLNVVDKIHQNTPLHWAVAAGN 229
>Hs18571424 [R] KOG0510 Ankyrin repeat protein
Length = 738
Score = 56.6 bits (135), Expect = 3e-08
Identities = 42/138 (30%), Positives = 66/138 (47%), Gaps = 15/138 (10%)
Query: 7 LHAACMNGDTEKVQQILS-----------EFPGAVKVKDDDGRYPLHWAVSFQQDNIIDI 55
LH A NGD E ++ L + V +D+DG PLH+A ++
Sbjct: 119 LHLAVQNGDLEMMKMCLDNGVQIDLVEMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNN 178
Query: 56 LLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQAN-NGITALHL 114
LL + I + + SP+H A+S G + ++LL + L + + +G+T LHL
Sbjct: 179 LLGFNVSIHSKS---KDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHL 235
Query: 115 ACSKKHLNVVQLLVERGA 132
A H VVQLL+++GA
Sbjct: 236 AAKNGHDKVVQLLLKKGA 253
Score = 53.1 bits (126), Expect = 3e-07
Identities = 47/178 (26%), Positives = 79/178 (43%), Gaps = 18/178 (10%)
Query: 37 GRYPLHWAVSFQQDNIIDILLSYMKKIDLD-----TILDESGWSPVHIASSIGSVTILEK 91
G +P+H AV ++I+L + ++ +D SP+H+A G + +++
Sbjct: 74 GCFPIHQAVLSGSKECMEIILKFGEEHGYSRQCHINFVDNGKASPLHLAVQNGDLEMMKM 133
Query: 92 LLNHTVEPNL-DLQA---------NNGITALHLACSKKHLNVVQLLVERGASVRIKDGLG 141
L++ V+ +L ++Q N+G T LH AC + V L+ S+ K
Sbjct: 134 CLDNGVQIDLVEMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDK 193
Query: 142 QLPLHRAAASGSVGIVSILCDKNSP---VNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
+ PLH AA+ G + L S +N D +G +PL A GH V L+ K
Sbjct: 194 KSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKK 251
>At5g53470 [I] KOG0817 Acyl-CoA-binding protein
Length = 338
Score = 56.6 bits (135), Expect = 3e-08
Identities = 34/102 (33%), Positives = 50/102 (48%), Gaps = 2/102 (1%)
Query: 77 VHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRI 136
+H + G V L K + + + N + + G T LH A + HLNV + LV++ A V
Sbjct: 222 IHAFAREGEVENLLKCIENGIPVNA--RDSEGRTPLHWAIDRGHLNVAEALVDKNADVNA 279
Query: 137 KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
KD GQ LH A + L + + IKD++G SPL
Sbjct: 280 KDNEGQTSLHYAVVCEREALAEFLVKQKADTTIKDEDGNSPL 321
>At2g25600 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 888
Score = 56.6 bits (135), Expect = 3e-08
Identities = 48/189 (25%), Positives = 81/189 (42%), Gaps = 30/189 (15%)
Query: 37 GRYPLHWAVSFQQDNIIDILL-SYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNH 95
G+ L ++ F D+LL +++ +D+ G + +HIA+S GS + LL H
Sbjct: 540 GKMDLPLSLCFAAARGDDLLLHQLLRRGSSPNEMDKDGRTALHIAASKGSHYCVVLLLEH 599
Query: 96 TVEPNL---------------------DLQANNGITAL--------HLACSKKHLNVVQL 126
+PN+ L A NG LA K L+ ++
Sbjct: 600 GADPNIRDSEGNVPLWEAIIGRHREIAKLLAENGAKLSLDSVSYFSGLAVEKNCLDALKD 659
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
+++ G V + DG G LHRA + G + IV L D+ + ++ D GW+P A +G+
Sbjct: 660 IIKYGGDVTLPDGNGTTALHRAVSEGHLEIVKFLLDQGADLDWPDSYGWTPRGLADHQGN 719
Query: 187 GDVAVTLVN 195
++ N
Sbjct: 720 EEIKTLFHN 728
>7302342 [R] KOG0508 Ankyrin repeat protein
Length = 332
Score = 56.6 bits (135), Expect = 3e-08
Identities = 40/133 (30%), Positives = 65/133 (48%), Gaps = 9/133 (6%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQAN--------NGITALHLACSKKHL 121
D +P+ +A+ +G+V ++ LL+H + +LD + N G TAL +A HL
Sbjct: 98 DGQSLTPLTMAAMMGNVKFVKTLLSH-YDVDLDRECNVIYDGMVVYGATALWVAAGMGHL 156
Query: 122 NVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
+V++LV+ GA++ PL A G + IV L D + VN + + L A
Sbjct: 157 QIVKMLVQAGAAINHNTKAQSSPLRAACYEGRLDIVEFLIDNGADVNATNLFNNNTLMIA 216
Query: 182 LAEGHGDVAVTLV 194
+GH V TL+
Sbjct: 217 AYKGHHLVVKTLL 229
>Hs20270347 [R] KOG0504 FOG: Ankyrin repeat
Length = 300
Score = 56.2 bits (134), Expect = 4e-08
Identities = 36/113 (31%), Positives = 58/113 (50%), Gaps = 8/113 (7%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG 139
+++ V +++LL +P + G TALH A + +VQLL++ GA +DG
Sbjct: 117 SANANDVETVQQLLEDGADPCA--ADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDG 174
Query: 140 LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL------FHALAEGH 186
LG PLH AA + V +++ L + V+ D+ G +PL + L EGH
Sbjct: 175 LGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/79 (37%), Positives = 43/79 (53%), Gaps = 2/79 (2%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D+ G + +H AS G+ I++ LL+H +PN + G T LHLA H+ V+ L+
Sbjct: 140 DDKGRTALHFASCNGNDQIVQLLLDHGADPN--QRDGLGNTPLHLAACTNHVPVITTLLR 197
Query: 130 RGASVRIKDGLGQLPLHRA 148
GA V D G+ PLH A
Sbjct: 198 GGARVDALDRAGRTPLHLA 216
>Hs7705278_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 860
Score = 56.2 bits (134), Expect = 4e-08
Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 13/203 (6%)
Query: 3 ADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDG-RYPLHWAVSFQQDNIIDILLSY-- 59
A+ L A N TE+ + E + D + PLH A+++ +++ ++L
Sbjct: 200 AELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKA 259
Query: 60 --------MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITA 111
++ I ++ D + + +A G TI +LL N + ++G T
Sbjct: 260 NALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTM--SDGQTL 317
Query: 112 LHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
LH+A ++ L+E A + ++ G+ L A + +V +C + + +++ D
Sbjct: 318 LHMAIQRQDSKSALFLLEHRADINVRPQAGETALQLAIRNQLPLVVDAICTRGADMSVPD 377
Query: 172 KNGWSPLFHALAEGHGDVAVTLV 194
+ G PL+ ALA D+A TLV
Sbjct: 378 EEGNPPLWLALANNLEDIASTLV 400
Score = 48.9 bits (115), Expect = 6e-06
Identities = 57/213 (26%), Positives = 87/213 (40%), Gaps = 14/213 (6%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A N D E V ++S + +D PLH V + I+ LL K+
Sbjct: 566 LHVAVQNSDIESVLSLISVHANVNSRAQDAPKLTPLHLVVQEGSEIIVRNLLLAGAKV-- 623
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
T L + + +H+A+ TI LL + V+ NG ALHLA LN ++
Sbjct: 624 -TELTKHRKTALHLAAQEDLPTICSVLLENAVD--FAAVDENGNNALHLAVMHGRLNNIR 680
Query: 126 -LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL-----CDKNSPVNIKDKNGWSPLF 179
LL E + GQ PLH G +I C P++ D +G + L
Sbjct: 681 VLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLL 740
Query: 180 HALAEGHGDVAVTLVNKYHALWEGETDNDDLSI 212
A +G+ ++ +V L G +N ++I
Sbjct: 741 LAYMKGNANLCRAIVRSGARL--GVNNNQGVNI 771
>Hs19923223_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 451
Score = 56.2 bits (134), Expect = 4e-08
Identities = 56/196 (28%), Positives = 92/196 (46%), Gaps = 17/196 (8%)
Query: 4 DFLLHAACMNGDTEKVQQIL-----SEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLS 58
D LH A ++G T ++QI+ ++ G V + + + PLH AV Q +++ LL
Sbjct: 6 DTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLL- 64
Query: 59 YMKKIDLD-TILDESGWSPVHIA--SSIGSVTILEKLLNH---TVEPNLDLQANNGITAL 112
++ D +LD G S +H+A + G+ +L LL V L + G+ +
Sbjct: 65 ---RVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPV 121
Query: 113 HLACSKKHLNVVQLLVERGASVRIKDGL-GQLPLHRAAASGSVGIVSILCDK-NSPVNIK 170
HLA + + LLV+ GA V + G+ LH A +G+V+ L K + VN +
Sbjct: 122 HLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNAR 181
Query: 171 DKNGWSPLFHALAEGH 186
G +PL A G+
Sbjct: 182 TFAGNTPLHLAAGLGY 197
>YDR264c [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 764
Score = 55.8 bits (133), Expect = 5e-08
Identities = 50/197 (25%), Positives = 90/197 (45%), Gaps = 17/197 (8%)
Query: 8 HAACMNGDTEKVQQILSEFPGAVKVKDDDGRYP-----LHWAVSFQQDNIIDILLSYMKK 62
H AC GD V++++ G + ++DG LHWA + +++D L+S +
Sbjct: 78 HTACQRGDLATVKEMIH---GKLLEVNNDGDSTEHITGLHWASINNRLSVVDFLVS--QG 132
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
D++ +P+H A+ G V I++ LL H +P + + G LHL+ + ++
Sbjct: 133 ADVNARAGALHATPLHWAARYGYVYIVDFLLKHGADPT--MTDDQGFNLLHLSVNSSNIM 190
Query: 123 VVQL----LVERG-ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSP 177
+V +V +G + +D G+ L AA G V+ L + + I D G++P
Sbjct: 191 LVLYVLFNVVSKGLLDIDCRDPKGRTSLLWAAYQGDSLTVAELLKFGASIKIADTEGFTP 250
Query: 178 LFHALAEGHGDVAVTLV 194
L +G V L+
Sbjct: 251 LHWGTVKGQPHVLKYLI 267
Score = 50.1 bits (118), Expect = 3e-06
Identities = 42/133 (31%), Positives = 62/133 (46%), Gaps = 4/133 (3%)
Query: 78 HIASSIGSV-TILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRI 136
H A G + T+ E + +E N D + IT LH A L+VV LV +GA V
Sbjct: 78 HTACQRGDLATVKEMIHGKLLEVNNDGDSTEHITGLHWASINNRLSVVDFLVSQGADVNA 137
Query: 137 KDG-LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
+ G L PLH AA G V IV L + + D G++ L H L+ ++ + L
Sbjct: 138 RAGALHATPLHWAARYGYVYIVDFLLKHGADPTMTDDQGFN-LLH-LSVNSSNIMLVLYV 195
Query: 196 KYHALWEGETDND 208
++ + +G D D
Sbjct: 196 LFNVVSKGLLDID 208
>Hs14764060 [R] KOG0508 Ankyrin repeat protein
Length = 669
Score = 55.8 bits (133), Expect = 5e-08
Identities = 41/161 (25%), Positives = 78/161 (47%), Gaps = 5/161 (3%)
Query: 36 DGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNH 95
+G PL WA S +D++ S +++ + +P+ A G + ++ L+
Sbjct: 82 EGAPPL-WAASAAGH--LDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGE 138
Query: 96 TVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVG 155
+ +L++ +G T L ++C K H + + L+E+GA V + G LH A SGS+
Sbjct: 139 H-QADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLE 197
Query: 156 IVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
I+ +L + + +D G +PL A GH ++ L+ +
Sbjct: 198 ILQLLLGCKARME-RDGYGMTPLLAASVTGHTNIVEYLIQE 237
Score = 50.8 bits (120), Expect = 2e-06
Identities = 43/135 (31%), Positives = 67/135 (48%), Gaps = 12/135 (8%)
Query: 77 VHIASSIGSVTILEKLLNHTVEPNLDL---QANNGITALHLACSKKHLNVVQLLVER-GA 132
V+ A+ G + +L+KLL+ LD + G T L +A HL+VV+ LV+R GA
Sbjct: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGA 66
Query: 133 SVRIKDGL--------GQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
SV + G PL A+A+G + +V L + + VN + +PL A +
Sbjct: 67 SVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFD 126
Query: 185 GHGDVAVTLVNKYHA 199
GH +V LV ++ A
Sbjct: 127 GHLEVVRYLVGEHQA 141
>7296935 [R] KOG0504 FOG: Ankyrin repeat
Length = 325
Score = 55.8 bits (133), Expect = 5e-08
Identities = 35/104 (33%), Positives = 57/104 (54%), Gaps = 2/104 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D+ ++ +H A+ G+ I + LL+ + +++ G TALH A HL +V+LLVE
Sbjct: 200 DDCDYTALHYAARNGNEPICKLLLDEG-KADVNAVTKAGATALHRAAMMGHLEIVKLLVE 258
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN-IKDK 172
A++ ++D GQ LHRA G + + IL K + +KDK
Sbjct: 259 HKANLLLQDESGQTALHRAVMRGHLEVCRILLAKEPTLKLVKDK 302
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/111 (29%), Positives = 56/111 (49%), Gaps = 1/111 (0%)
Query: 110 TALHLACSKKHLNVVQLLVERG-ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN 168
TALH A + + +LL++ G A V G LHRAA G + IV +L + + +
Sbjct: 205 TALHYAARNGNEPICKLLLDEGKADVNAVTKAGATALHRAAMMGHLEIVKLLVEHKANLL 264
Query: 169 IKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKICVDA 219
++D++G + L A+ GH +V L+ K L + D ++ + I +A
Sbjct: 265 LQDESGQTALHRAVMRGHLEVCRILLAKEPTLKLVKDKKDKIAFEYIMENA 315
>YMR068w [R] KOG0504 FOG: Ankyrin repeat
Length = 426
Score = 55.5 bits (132), Expect = 6e-08
Identities = 44/176 (25%), Positives = 79/176 (44%), Gaps = 6/176 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAV-KVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
L A + G+ V+++L P + + ++G LH+A S+ +I + L +
Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYA-SYHGRYLICVYLIQLGHDKH 67
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
+ I G + VH+A G L LL ++ + NG +H+AC + +
Sbjct: 68 ELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPR-FINHRGENGRAPIHIACMNDYYQCLS 126
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNS---PVNIKDKNGWSPL 178
LL+ GA + + D G PLH GS+ + +L ++ N++DK W P+
Sbjct: 127 LLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPI 182
Score = 52.4 bits (124), Expect = 5e-07
Identities = 46/168 (27%), Positives = 76/168 (44%), Gaps = 8/168 (4%)
Query: 49 QDNIIDILLSYMKKIDLDTILD-ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN 107
+ N++ + + DL T +D E+GWS +H AS G I L+ + + ++
Sbjct: 15 EGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFK 74
Query: 108 GITALHLACSKKHLNVVQLLVERGAS-VRIKDGLGQLPLHRAAASGSVGIVSILCDKNSP 166
G T +HLA K H + LL+++ + + G+ P+H A + +S+L +
Sbjct: 75 GNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGAD 134
Query: 167 VNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDK 214
+ + D NG +PL L G L+N EGE DD DK
Sbjct: 135 LWVMDTNGDTPLHVCLEYGSISCMKMLLN------EGEVSLDDNVRDK 176
>Hs19718743 [T] KOG2209 Oxysterol-binding protein
Length = 927
Score = 55.5 bits (132), Expect = 6e-08
Identities = 29/71 (40%), Positives = 43/71 (59%)
Query: 104 QANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDK 163
++N G T LHLAC H VVQ L++ GA V + + +G PLHRAA +G +V +L +
Sbjct: 44 KSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEY 103
Query: 164 NSPVNIKDKNG 174
N+ I + +G
Sbjct: 104 NADTTIVNGSG 114
>Hs19718741 [T] KOG2209 Oxysterol-binding protein
Length = 950
Score = 55.5 bits (132), Expect = 6e-08
Identities = 29/71 (40%), Positives = 43/71 (59%)
Query: 104 QANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDK 163
++N G T LHLAC H VVQ L++ GA V + + +G PLHRAA +G +V +L +
Sbjct: 44 KSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEY 103
Query: 164 NSPVNIKDKNG 174
N+ I + +G
Sbjct: 104 NADTTIVNGSG 114
>YIL112w [R] KOG0504 FOG: Ankyrin repeat
Length = 1083
Score = 55.1 bits (131), Expect = 8e-08
Identities = 36/109 (33%), Positives = 57/109 (52%), Gaps = 7/109 (6%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDL--QANNGITALHLACSKKHLNVVQLL 127
D G + + IA G +++K++ E D+ Q N G TALH A + H+ +V+LL
Sbjct: 327 DSGGRTRLQIACDKGKYDVVKKMIE---EGGYDINDQDNAGNTALHEAALQGHIEIVELL 383
Query: 128 VERGASVRIK--DGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
+E GA V IK + G PL A+A+G + +V L + I++ G
Sbjct: 384 IENGADVNIKSIEMFGDTPLIDASANGHLDVVKYLLKNGADPTIRNAKG 432
>Hs14742395 [R] KOG0514 Ankyrin repeat protein
Length = 1194
Score = 55.1 bits (131), Expect = 8e-08
Identities = 50/172 (29%), Positives = 89/172 (51%), Gaps = 14/172 (8%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSY-MKKIDLDTILDESGWSPVHIASSIG---- 84
+ + D +G LH++VS I+ +LL + +D +++G++P+ +A+
Sbjct: 997 INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQ---NKAGYTPIMLAALAAVEAE 1053
Query: 85 -SVTILEKLLNHTVEPNLDLQANN-GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQ 142
+ I+E+L +++ +A+ G TAL LA S +++V+ L+ GA V I+D G
Sbjct: 1054 KDMRIVEELFGCG---DVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGS 1110
Query: 143 LPLHRAAASGSVGIVS-ILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTL 193
L A+ G V IV +L +++D +G + L AL GH D+AV L
Sbjct: 1111 TALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL 1162
>CE27598 [R] KOG0504 FOG: Ankyrin repeat
Length = 840
Score = 55.1 bits (131), Expect = 8e-08
Identities = 46/161 (28%), Positives = 71/161 (43%), Gaps = 3/161 (1%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL 93
D D R P+HW S N+ I Y DL D+ + +H A+S G ++E L
Sbjct: 173 DADDRTPIHWCSS--NGNLEAIKALYNSGGDL-LCRDKEHLTILHCAASHGYHEVIEFAL 229
Query: 94 NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGS 153
H +P +D G TAL A S H L++ A+ +D H AA+ G
Sbjct: 230 KHVNKPFIDEIDRAGHTALFYAISFGHYESALKLLQNNANPNHQDQRLATAAHSAASKGQ 289
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
+ ++ +L N+ +I++ G P A+ G DV L+
Sbjct: 290 MRMLKLLKQFNASFDIQNYRGDLPFHEAVQAGSKDVVEWLL 330
>CE20486 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 1016
Score = 55.1 bits (131), Expect = 8e-08
Identities = 61/244 (25%), Positives = 102/244 (41%), Gaps = 37/244 (15%)
Query: 9 AACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDT 67
+ACM+GD E+V+++L++ GA + DG LH +V + ++ L K D++
Sbjct: 61 SACMSGDEEEVEELLNK--GANINTCTVDGLTALHQSVIDSKPEMVRFLCE--KGADVNA 116
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACS---------- 117
D GW+P+H A+ G+V I+ L H + L + ++ AL LA
Sbjct: 117 -QDNEGWTPLHAAACCGNVAIVRYLCQHGAD--LSIVNSDKELALDLAVDEQCRDYLDDD 173
Query: 118 -KKHLNVVQLLVERGASVRIKD----------------GLGQLPLHRAAASGSVGIVSIL 160
K+ + + ++ +KD G +H AA G ++ +L
Sbjct: 174 YKRQMIDLDACRDQELQTMLKDVNMWMSQGEYRDIPHHRTGGTAMHVAAGRGYTQLLELL 233
Query: 161 CDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWE-GETDNDDLSI-DKICVD 218
V +D GW+PL A D L+ L + T D L + DK C+D
Sbjct: 234 IKAGGNVRAQDVEGWTPLHAAAHWAERDACKILLENGAELSDLTFTGADVLGVADKECID 293
Query: 219 AKVK 222
V+
Sbjct: 294 YLVE 297
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/115 (30%), Positives = 54/115 (46%), Gaps = 7/115 (6%)
Query: 115 ACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
AC V+ L+ +GA++ G LH++ +V LC+K + VN +D G
Sbjct: 62 ACMSGDEEEVEELLNKGANINTCTVDGLTALHQSVIDSKPEMVRFLCEKGADVNAQDNEG 121
Query: 175 WSPLFHALAEGHGDVAVTLVNKYHALWEGETDND-----DLSIDKICVDAKVKDY 224
W+PL HA A G+VA+ H ++D DL++D+ C D DY
Sbjct: 122 WTPL-HA-AACCGNVAIVRYLCQHGADLSIVNSDKELALDLAVDEQCRDYLDDDY 174
>At4g35450 [R] KOG0504 FOG: Ankyrin repeat
Length = 342
Score = 55.1 bits (131), Expect = 8e-08
Identities = 36/104 (34%), Positives = 53/104 (50%), Gaps = 2/104 (1%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
S VH +S+G V L+ L N D + + G TALH AC L Q+L++ GASV
Sbjct: 220 SIVHQTASLGDVEGLKAAL--ASGGNKDEEDSEGRTALHFACGYGELKCAQVLIDAGASV 277
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
D PLH AA G VS+L + + V +++ + +P+
Sbjct: 278 NAVDKNKNTPLHYAAGYGRKECVSLLLENGAAVTLQNLDEKTPI 321
>7296403 [T] KOG0195 Integrin-linked kinase
Length = 448
Score = 55.1 bits (131), Expect = 8e-08
Identities = 41/138 (29%), Positives = 68/138 (48%), Gaps = 7/138 (5%)
Query: 42 HWAVSFQQDNIIDILLSYMKKIDLDTIL-DESGWSPVHIASSIGSVTILEKLLNHTVEPN 100
HW ++ N I + L ++ + + D L D+ G+SP+H + G ++E LL N
Sbjct: 6 HWC---REGNSIQVRL-WLDETEHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVN 61
Query: 101 LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
++ LHLA + H +VVQ+L++ + V + G PLH A G I L
Sbjct: 62 ATNMGDD--IPLHLAAAHGHRDVVQMLIKERSDVNAVNEHGNTPLHYACFWGYDMICEDL 119
Query: 161 CDKNSPVNIKDKNGWSPL 178
+ + V I +K+G +PL
Sbjct: 120 LNAGAQVGIANKDGHTPL 137
Score = 53.9 bits (128), Expect = 2e-07
Identities = 30/98 (30%), Positives = 54/98 (54%)
Query: 98 EPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIV 157
E + +L ++G + LH + H +V+ L++RG+ V + +PLH AAA G +V
Sbjct: 24 EHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVNATNMGDDIPLHLAAAHGHRDVV 83
Query: 158 SILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
+L + S VN +++G +PL +A G+ + L+N
Sbjct: 84 QMLIKERSDVNAVNEHGNTPLHYACFWGYDMICEDLLN 121
Score = 53.1 bits (126), Expect = 3e-07
Identities = 37/141 (26%), Positives = 66/141 (46%), Gaps = 5/141 (3%)
Query: 11 CMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILD 70
C G++ +V+ L E + DD G PLHW +++ LL +++ + D
Sbjct: 8 CREGNSIQVRLWLDETEHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVNATNMGD 67
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
+ P+H+A++ G +++ L+ + N +G T LH AC + + + L+
Sbjct: 68 D---IPLHLAAAHGHRDVVQMLIKERSDVN--AVNEHGNTPLHYACFWGYDMICEDLLNA 122
Query: 131 GASVRIKDGLGQLPLHRAAAS 151
GA V I + G PL +A S
Sbjct: 123 GAQVGIANKDGHTPLEKAKPS 143
>YOR034c [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 749
Score = 54.7 bits (130), Expect = 1e-07
Identities = 50/186 (26%), Positives = 79/186 (41%), Gaps = 11/186 (5%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC+N + +L + G LHWA + I+D+LL +
Sbjct: 88 LHWACINNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGAD---P 144
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPN----LDLQANNGITALHLACSKKHLN 122
T+ DE G + +H + ++ ++ +L V N +D + NN T L A +
Sbjct: 145 TLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFL 204
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDK-NSPVNIKDKNGWSPLFHA 181
V+LL++ G++V D G LH A G ++CD S N ++N
Sbjct: 205 TVELLLKFGSTVAWTDNRGFNALHCALVGGD---QRVICDLILSGANFYERNNQKQDCFD 261
Query: 182 LAEGHG 187
LAEG G
Sbjct: 262 LAEGMG 267
>Hs22047757 [M] KOG4177 Ankyrin
Length = 521
Score = 54.7 bits (130), Expect = 1e-07
Identities = 33/107 (30%), Positives = 56/107 (51%), Gaps = 5/107 (4%)
Query: 73 GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGA 132
G++P+H+AS G++ +++ LL H + N + G + LH A + H ++V LL++ GA
Sbjct: 2 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKL--GYSPLHQAAQQGHTDIVTLLLKNGA 59
Query: 133 SVRIKDGLGQLPLHRAAASGSVGIVSIL---CDKNSPVNIKDKNGWS 176
S G PL A G + + +L D+ S V + DK+ S
Sbjct: 60 SPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMS 106
Score = 51.2 bits (121), Expect = 1e-06
Identities = 32/89 (35%), Positives = 49/89 (54%), Gaps = 2/89 (2%)
Query: 108 GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV 167
G T LH+A ++ +V+ L++ A V K LG PLH+AA G IV++L +
Sbjct: 2 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 61
Query: 168 NIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
N +G +PL A+A+ G ++VT V K
Sbjct: 62 NEVSSDGTTPL--AIAKRLGYISVTDVLK 88
>CE28127 [R] KOG0504 FOG: Ankyrin repeat
Length = 772
Score = 54.7 bits (130), Expect = 1e-07
Identities = 54/224 (24%), Positives = 84/224 (37%), Gaps = 46/224 (20%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILL-------- 57
++H A G + + ++ P + + +G PLH A ID LL
Sbjct: 279 IIHVAAERGLDKMLDTVMLLLPKDINSQAANGLTPLHLAARHAHAACIDRLLGTSTCIPC 338
Query: 58 ------------------SYMKKIDLDTIL----------DESGWSPVHIASSIGSVTIL 89
S KK + IL + S +P+ IA G V+ +
Sbjct: 339 VPNNFGDTLLHEVCRLPESSNKKAAISRILTNTRANIHHVNNSNMTPIQIAIMSGHVSTV 398
Query: 90 EKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAA 149
E+LL + + G++ALH A + H NVV L+ G V +D G+ LH A
Sbjct: 399 EQLLLLRASYR-NTTSKTGMSALHFAAASGHANVVNKLISLGLEVHRRDKFGRGVLHYAL 457
Query: 150 AS---------GSVGIVSILCDKNSPVNIKDKNGWSPLFHALAE 184
+ + L +P NI D NG +P+F + E
Sbjct: 458 EKWTGEAEKDCNRLAAIQALVKAGAPSNIIDLNGQTPVFQLIRE 501
Score = 48.5 bits (114), Expect = 8e-06
Identities = 45/173 (26%), Positives = 77/173 (44%), Gaps = 17/173 (9%)
Query: 33 KDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKL 92
+D + R +H A D ++D ++ + K D+++ +G +P+H+A+ +++L
Sbjct: 272 RDSENRTIIHVAAERGLDKMLDTVMLLLPK-DINSQA-ANGLTPLHLAARHAHAACIDRL 329
Query: 93 LNHTV----EPNLDLQANNGITALHLAC-----SKKHLNVVQLLVERGASVRIKDGLGQL 143
L + PN N G T LH C S K + ++L A++ +
Sbjct: 330 LGTSTCIPCVPN-----NFGDTLLHEVCRLPESSNKKAAISRILTNTRANIHHVNNSNMT 384
Query: 144 PLHRAAASGSVGIVS-ILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
P+ A SG V V +L + S N K G S L A A GH +V L++
Sbjct: 385 PIQIAIMSGHVSTVEQLLLLRASYRNTTSKTGMSALHFAAASGHANVVNKLIS 437
>At5g37500 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 735
Score = 54.7 bits (130), Expect = 1e-07
Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A G E + L + V +KD G PL AV Q+ +I +L+ +L+
Sbjct: 483 LHLAACRG-YEDITLFLIQEGVDVNLKDKFGHTPLFEAVKAGQEGVIGLLVKEGASFNLE 541
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D + +A G L++LL+ + PN + + T LH+A S+ + ++
Sbjct: 542 ---DSGNFLCTTVAK--GDSDFLKRLLSSGMNPNSEDYDHR--TPLHVAASEGLFLMAKM 594
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCD-KNSPVNI 169
LVE GASV KD G PL A G+ ++ +L D KN+ +I
Sbjct: 595 LVEAGASVISKDRWGNSPLDEARLCGNKKLIKLLEDVKNAQSSI 638
Score = 52.8 bits (125), Expect = 4e-07
Identities = 40/176 (22%), Positives = 79/176 (44%), Gaps = 17/176 (9%)
Query: 26 FPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGS 85
F +++ DGR L+ + ++ N +KK++ D ++ G +A + S
Sbjct: 400 FSNILEIYFHDGRTILNNIMEEKESN------DRIKKLESDIVI-HIGKQEAELALKVNS 452
Query: 86 VTI------LEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG 139
L+ L+ +PN +G + LHLA + + ++ L++ G V +KD
Sbjct: 453 AAFQGDFYQLKSLIRSGADPNKT--DYDGRSPLHLAACRGYEDITLFLIQEGVDVNLKDK 510
Query: 140 LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
G PL A +G G++ +L + + N++D + L +A+G D L++
Sbjct: 511 FGHTPLFEAVKAGQEGVIGLLVKEGASFNLEDSGNF--LCTTVAKGDSDFLKRLLS 564
>At3g12360 [R] KOG0504 FOG: Ankyrin repeat
Length = 590
Score = 54.7 bits (130), Expect = 1e-07
Identities = 60/214 (28%), Positives = 89/214 (41%), Gaps = 26/214 (12%)
Query: 4 DFLLHAACMNGDTEKVQQIL----SEFPGAVKVKDDD-----------------GRYPLH 42
D LH A GD VQQIL S+ G + ++ D G L
Sbjct: 75 DTELHLAAQRGDLAAVQQILKDINSQMEGILSGEEFDAEVAEIRASIVNEVNELGETALF 134
Query: 43 WAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLD 102
A +++ LL Y + + + SG+ P+HIA+ G I+E LL+H +
Sbjct: 135 TAADKGHLDVVKELLKYSSRESIAK-KNRSGYDPLHIAAIQGHHAIVEVLLDHDATLSQT 193
Query: 103 LQANNGITALHLACSKKHLNVV-QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILC 161
+N T L A + H VV QLL + G + I + LH AA G V ++ L
Sbjct: 194 FGPSNA-TPLVSAAMRGHTEVVNQLLSKAGNLLEISRSNNKNALHLAARQGHVEVIKALL 252
Query: 162 DKNSPVNIK-DKNGWSPLFHALAEGHGDVAVTLV 194
K+ + + DK G + L H +G V L+
Sbjct: 253 SKDPQLARRIDKKGQTAL-HMAVKGQSSEVVKLL 285
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/123 (30%), Positives = 64/123 (51%), Gaps = 5/123 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L +A M G TE V Q+LS+ +++ + + LH A +I LLS K L
Sbjct: 202 LVSAAMRGHTEVVNQLLSKAGNLLEISRSNNKNALHLAARQGHVEVIKALLS--KDPQLA 259
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI-TALHLACSKKHLNVVQ 125
+D+ G + +H+A S +++ LL+ +P + +Q + TALH+A KK +V+
Sbjct: 260 RRIDKKGQTALHMAVKGQSSEVVKLLLD--ADPAIVMQPDKSCNTALHVATRKKRAEIVE 317
Query: 126 LLV 128
LL+
Sbjct: 318 LLL 320
>7291960_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 507
Score = 54.7 bits (130), Expect = 1e-07
Identities = 41/124 (33%), Positives = 56/124 (45%), Gaps = 2/124 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D G S +H A+ + I E LL + N+D + T LHLAC H +V LL+
Sbjct: 83 DWLGMSALHFAAMNNQLEICEILLQGGI--NMDGKTKVDRTPLHLACYYGHERIVSLLLA 140
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDV 189
SV +D L PLH A GIV +L + V + K G +P+ A+ DV
Sbjct: 141 LKCSVNSRDMLRMTPLHWAVEKKHKGIVRLLLKCQADVTLVSKFGKTPIGLAVYTEQADV 200
Query: 190 AVTL 193
L
Sbjct: 201 LAEL 204
>Hs7706007 [R] KOG0504 FOG: Ankyrin repeat
Length = 175
Score = 54.3 bits (129), Expect = 1e-07
Identities = 33/93 (35%), Positives = 42/93 (44%)
Query: 108 GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV 167
G TALH A H V Q L+E GA + G LHRA+ G I +L S
Sbjct: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
Query: 168 NIKDKNGWSPLFHALAEGHGDVAVTLVNKYHAL 200
+ D +G + L A GHGD+ L+ AL
Sbjct: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQHSPAL 156
Score = 53.1 bits (126), Expect = 3e-07
Identities = 31/91 (34%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D +G++ +H AS G + + LL + D Q + G TALH A H + +LL+
Sbjct: 61 DSAGYTALHYASRNGHYAVCQFLLESGAK--CDAQTHGGATALHRASYCGHTEIARLLLS 118
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
G++ R+ D G LH+AA G I S+L
Sbjct: 119 HGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
>Hs6981364 [I] KOG0513 Ca2+-independent phospholipase A2
Length = 806
Score = 54.3 bits (129), Expect = 1e-07
Identities = 46/175 (26%), Positives = 80/175 (45%), Gaps = 8/175 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC G E V+ +L + +G YP+H A+ F Q ++++S M +
Sbjct: 224 LHLACQLGKQEMVRVLLL-CNARCNIMGPNG-YPIHSAMKFSQKGCAEMIIS-MDSSQIH 280
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ G SP+H A + +L K N++ ++ G TALH+A + + +
Sbjct: 281 SKDPRYGASPLHWAKNAEMARMLLKR-----GCNVNSTSSAGNTALHVAVMRNRFDCAIV 335
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
L+ GA+ + G PLH A + +V ++ L + V+ + G +P F A
Sbjct: 336 LLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
>Hs22064210 [R] KOG0504 FOG: Ankyrin repeat
Length = 960
Score = 54.3 bits (129), Expect = 1e-07
Identities = 34/98 (34%), Positives = 52/98 (52%), Gaps = 3/98 (3%)
Query: 85 SVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLP 144
SV +++ L N +LD +A +G+TALH A ++ ++ L+E GAS KD G P
Sbjct: 338 SVEVIKALKNGGA--HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTP 395
Query: 145 L-HRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
L H A G +L +++ V KD+NGW + A
Sbjct: 396 LYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQA 433
>Hs20562143 [R] KOG0504 FOG: Ankyrin repeat
Length = 583
Score = 54.3 bits (129), Expect = 1e-07
Identities = 48/168 (28%), Positives = 83/168 (48%), Gaps = 12/168 (7%)
Query: 50 DNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI 109
D I+ +LL +++ T G +P+ +ASS G+ +I LL E L+++ G
Sbjct: 9 DTIVHLLLEAGVSVNVPT---PEGQTPLMLASSCGNESIAYFLLQQGAE--LEMKDIQGW 63
Query: 110 TALHLACSKKHLNVVQLLVERGASVRIKDGL-GQLPLHRAAASGSVGIVSILCDKNSPVN 168
TAL S H ++V+ L++ GA+ +++ + G PL AAA+G IV + V+
Sbjct: 64 TALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVD 123
Query: 169 IKDKNGWSPLFHALAEGHGDVAVTLVNKY-----HALWEGETDNDDLS 211
+D +G + A GH + V L++ Y +L+ +DLS
Sbjct: 124 ARDHSGATARMLAKQYGHMKI-VALMDTYSPSLPKSLYRSPEKYEDLS 170
Score = 52.8 bits (125), Expect = 4e-07
Identities = 25/67 (37%), Positives = 37/67 (54%)
Query: 120 HLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLF 179
H +V LL+E G SV + GQ PL A++ G+ I L + + + +KD GW+ LF
Sbjct: 8 HDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALF 67
Query: 180 HALAEGH 186
H + GH
Sbjct: 68 HCTSAGH 74
Score = 48.9 bits (115), Expect = 6e-06
Identities = 36/117 (30%), Positives = 57/117 (47%), Gaps = 3/117 (2%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG 139
AS IG TI+ LL V N+ G T L LA S + ++ L+++GA + +KD
Sbjct: 3 ASYIGHDTIVHLLLEAGVSVNVPTP--EGQTPLMLASSCGNESIAYFLLQQGAELEMKDI 60
Query: 140 LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDK-NGWSPLFHALAEGHGDVAVTLVN 195
G L ++G +V L D + N+++ G++PL A A GH + +N
Sbjct: 61 QGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLN 117
>Hs20561564 [I] KOG0513 Ca2+-independent phospholipase A2
Length = 806
Score = 54.3 bits (129), Expect = 1e-07
Identities = 46/175 (26%), Positives = 80/175 (45%), Gaps = 8/175 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC G E V+ +L + +G YP+H A+ F Q ++++S M +
Sbjct: 224 LHLACQLGKQEMVRVLLL-CNARCNIMGPNG-YPIHSAMKFSQKGCAEMIIS-MDSSQIH 280
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ G SP+H A + +L K N++ ++ G TALH+A + + +
Sbjct: 281 SKDPRYGASPLHWAKNAEMARMLLKR-----GCNVNSTSSAGNTALHVAVMRNRFDCAIV 335
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
L+ GA+ + G PLH A + +V ++ L + V+ + G +P F A
Sbjct: 336 LLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
>Hs14150037 [R] KOG0504 FOG: Ankyrin repeat
Length = 422
Score = 54.3 bits (129), Expect = 1e-07
Identities = 36/111 (32%), Positives = 63/111 (56%), Gaps = 5/111 (4%)
Query: 37 GRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHT 96
G LH A Q + +LLS + ID++ + D +GW+P+H A + G+ ++++L
Sbjct: 171 GETALHRACINNQVEKLILLLS-LPGIDIN-VKDNAGWTPLHEACNYGNTVCVQEILQRC 228
Query: 97 VEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRI--KDGLGQLPL 145
E +L Q +G+T LH A S H+ + +LL++ G V + ++ G+LPL
Sbjct: 229 PEVDLLTQV-DGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 278
Score = 50.8 bits (120), Expect = 2e-06
Identities = 35/90 (38%), Positives = 50/90 (54%), Gaps = 4/90 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH AC+N EK+ +LS PG + VKD+ G PLH A ++ + +L ++DL
Sbjct: 175 LHRACINNQVEKLILLLS-LPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDL 233
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNH 95
T +D G +P+H A S G V I + LL H
Sbjct: 234 LTQVD--GVTPLHDALSNGHVEIGKLLLQH 261
>7294864 [R] KOG0504 FOG: Ankyrin repeat
Length = 358
Score = 54.3 bits (129), Expect = 1e-07
Identities = 34/115 (29%), Positives = 60/115 (51%), Gaps = 6/115 (5%)
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
I+ +S + A+S ++ +L ++L PN + N + LHLA + ++ +VQ L
Sbjct: 158 IIVQSNGRKLRTAASTCNIELLNRILEGGANPNAADEYNR--SPLHLAACRGYIPIVQQL 215
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVG----IVSILCDKNSPVNIKDKNGWSPL 178
++ GA+ + D LG PLH A S S +V +L + V++ D++ SPL
Sbjct: 216 LKYGANPNVVDSLGNTPLHLAVISASSNNFNVVVGVLLQGGASVHMYDRSNKSPL 270
>HsM11545809 [M] KOG4177 Ankyrin
Length = 416
Score = 53.9 bits (128), Expect = 2e-07
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 7/163 (4%)
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
E +S ++I + G + L+K + +D++ N T L AC+ +++VV+ L+E+
Sbjct: 130 EKVFSNINIITKAGDLASLKKAFESGIP--VDMKDNYYKTPLMTACASGNIDVVKFLLEK 187
Query: 131 GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVA 190
GA+V D PLH A +G IV +L + + ++ N +PL A+ D
Sbjct: 188 GANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTV 247
Query: 191 VTLVN---KYHALWEGETDNDDLSIDKICVDAKVKDYFLSKVE 230
L++ K+ E + + + K D ++ D K++
Sbjct: 248 KYLLDIGAKFQL--ENRKGHSAMDVAKAYADYRIIDLIKEKLD 288
>Hs22060186 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 632
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/99 (35%), Positives = 50/99 (50%), Gaps = 10/99 (10%)
Query: 110 TALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNI 169
T LH A + HL++V L++ GA + DG G +H AA G IV+ L K V++
Sbjct: 126 TPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDM 185
Query: 170 KDKNGWSPLFHALAEGHG----------DVAVTLVNKYH 198
D+NG +PL A H +V+V L +KYH
Sbjct: 186 MDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYH 224
>Hs21450703 [R] KOG0504 FOG: Ankyrin repeat
Length = 258
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/107 (32%), Positives = 56/107 (51%), Gaps = 2/107 (1%)
Query: 88 ILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHR 147
+++K L +PN + + TALH AC K H +V L+ GA+V +D L + P+
Sbjct: 126 LIDKYLTDGGDPNAHDKLHR--TALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFW 183
Query: 148 AAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
A G + I+ L ++ + VN +DK G +PL A+ H D L+
Sbjct: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLI 230
>Hs21314697 [M] KOG4177 Ankyrin
Length = 776
Score = 53.9 bits (128), Expect = 2e-07
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 7/163 (4%)
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
E +S ++I + G + L+K + +D++ N T L AC+ +++VV+ L+E+
Sbjct: 490 EKVFSNINIITKAGDLASLKKAFESGIP--VDMKDNYYKTPLMTACASGNIDVVKFLLEK 547
Query: 131 GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVA 190
GA+V D PLH A +G IV +L + + ++ N +PL A+ D
Sbjct: 548 GANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTV 607
Query: 191 VTLVN---KYHALWEGETDNDDLSIDKICVDAKVKDYFLSKVE 230
L++ K+ E + + + K D ++ D K++
Sbjct: 608 KYLLDIGAKFQL--ENRKGHSAMDVAKAYADYRIIDLIKEKLD 648
>Hs20543460 [R] KOG0504 FOG: Ankyrin repeat
Length = 430
Score = 53.9 bits (128), Expect = 2e-07
Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 2/113 (1%)
Query: 74 WSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGAS 133
WS +H A+ G I+ LL H N+ L+ G+T L +A H +V++ L+ +G
Sbjct: 20 WSAMHEAAKQGRKDIVALLLKH--GGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGD 77
Query: 134 VRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
V G L AA G+ +S+L + N+ ++ G P+ A EGH
Sbjct: 78 VLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGH 130
Score = 50.1 bits (118), Expect = 3e-06
Identities = 44/154 (28%), Positives = 76/154 (48%), Gaps = 7/154 (4%)
Query: 41 LHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN 100
+H A + +I+ +LL + + L D G +P+ +A+ G +LE L+ H
Sbjct: 23 MHEAAKQGRKDIVALLLKHGGNVHLR---DGFGVTPLGVAAEYGHCDVLEHLI-HKGGDV 78
Query: 101 LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
L L A++G + L A + + + LL+E G S + + G LP+HRAA G + L
Sbjct: 79 LAL-ADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYL 137
Query: 161 CDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV 194
S I+ K+G +P+ H+ A+G + L+
Sbjct: 138 IPVTSKNAIR-KSGLTPI-HSAADGQNAQCLELL 169
>Hs14720884 [R] KOG0504 FOG: Ankyrin repeat
Length = 823
Score = 53.9 bits (128), Expect = 2e-07
Identities = 53/169 (31%), Positives = 79/169 (46%), Gaps = 8/169 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC +G + V +++ + + D + R PL AV Q++ ILL + +L
Sbjct: 71 LHLACASGHVQVVTLLVNR-KCQIDICDKENRTPLIQAVHCQEEACAVILLKHGANPNLK 129
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPN-LDLQANNGITALHLACSKKHLNVVQ 125
I G + +H A S ++ EKLL+H LD +N T L A K +V+
Sbjct: 130 DIY---GNTALHYAVYSESTSLAEKLLSHGAHIEALDKDSN---TPLLFAIICKKEKMVE 183
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
L+++ AS D L + L A S GIVSIL +N V +D G
Sbjct: 184 FLLKKKASTHAVDRLRRSALMLAVYYDSPGIVSILLKQNIDVFAQDMCG 232
Score = 53.1 bits (126), Expect = 3e-07
Identities = 46/177 (25%), Positives = 76/177 (41%), Gaps = 7/177 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
+H A + GD +V++ L+ G + +D R LH A + ++ +L++ +ID
Sbjct: 37 IHRAAVKGDAAEVERCLARRSGDLDARDKQHRTALHLACASGHVQVVTLLVNRKCQID-- 94
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNL-DLQANNGITALHLACSKKHLNVVQ 125
I D+ +P+ A LL H PNL D+ N TALH A + ++ +
Sbjct: 95 -ICDKENRTPLIQAVHCQEEACAVILLKHGANPNLKDIYGN---TALHYAVYSESTSLAE 150
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
L+ GA + D PL A +V L K + + D+ S L A+
Sbjct: 151 KLLSHGAHIEALDKDSNTPLLFAIICKKEKMVEFLLKKKASTHAVDRLRRSALMLAV 207
Score = 52.0 bits (123), Expect = 7e-07
Identities = 45/159 (28%), Positives = 69/159 (43%), Gaps = 2/159 (1%)
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
+S +H A+ G +E+ L +LD + TALHLAC+ H+ VV LLV R
Sbjct: 31 DSELQKIHRAAVKGDAAEVERCLARR-SGDLDARDKQHRTALHLACASGHVQVVTLLVNR 89
Query: 131 GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVA 190
+ I D + PL +A IL + N+KD G + L +A+ +A
Sbjct: 90 KCQIDICDKENRTPLIQAVHCQEEACAVILLKHGANPNLKDIYGNTALHYAVYSESTSLA 149
Query: 191 VTLVNK-YHALWEGETDNDDLSIDKICVDAKVKDYFLSK 228
L++ H + N L IC K+ ++ L K
Sbjct: 150 EKLLSHGAHIEALDKDSNTPLLFAIICKKEKMVEFLLKK 188
>Hs14149716 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 782
Score = 53.9 bits (128), Expect = 2e-07
Identities = 54/196 (27%), Positives = 84/196 (42%), Gaps = 29/196 (14%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC++ + E V+ L E V D++G PLH A S +I LLS+ I
Sbjct: 105 LHQACIDENLEVVR-FLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI--- 160
Query: 67 TILDESGWSPVHIASSIGSVTIL------------------EKLLNHTVEPNLDLQA--- 105
++ G P+ +A S +L E+LL H L+ A
Sbjct: 161 AAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPE 220
Query: 106 ----NNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILC 161
G +ALH+A +K ++ V++LL++ G ++DG G PLH AA G +L
Sbjct: 221 ARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLA 280
Query: 162 DKNSPVNIKDKNGWSP 177
+ ++ G P
Sbjct: 281 EHGGGMDSLTHAGQRP 296
Score = 53.5 bits (127), Expect = 2e-07
Identities = 31/78 (39%), Positives = 44/78 (55%)
Query: 101 LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
LD +GI+ALH AC ++L VV+ LVE+GA+V D G PLH AA+ G + I L
Sbjct: 94 LDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYL 153
Query: 161 CDKNSPVNIKDKNGWSPL 178
+ + + +G PL
Sbjct: 154 LSHGANIAAVNSDGDLPL 171
Score = 49.3 bits (116), Expect = 4e-06
Identities = 59/224 (26%), Positives = 94/224 (41%), Gaps = 51/224 (22%)
Query: 3 ADFLLHAACMNGDTEKVQQILSEF-------------PGAVKVKDD---DGRYPLHWAVS 46
A+FL AAC GD ++ + +L P A V D DG LH A
Sbjct: 53 AEFL--AACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACI 110
Query: 47 FQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQAN 106
+ ++ L+ ++ D GW+P+H+A+S G + I LL+H N+ +
Sbjct: 111 DENLEVVRFLVEQGATVNQ---ADNEGWTPLHVAASCGYLDIARYLLSHGA--NIAAVNS 165
Query: 107 NGITALHLACSKKHLNVVQL-LVERGASV----RIKDGL-----------GQLP------ 144
+G L LA S +++ + RG V R ++ L G +P
Sbjct: 166 DGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPR 225
Query: 145 -----LHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
LH AAA G + ++ +L ++D +GW+PL HA A
Sbjct: 226 TGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPL-HAAA 268
>7294632_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 959
Score = 53.9 bits (128), Expect = 2e-07
Identities = 49/181 (27%), Positives = 87/181 (47%), Gaps = 7/181 (3%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKK 62
+ L AA +G + V +LS GA + ++ G L AV ++++ LL +
Sbjct: 582 ELALTAAARHGCIDVVGILLSR--GAQIDARNRQGYSALWLAVKEGHWSVVEHLLQ--RG 637
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLN 122
LD L ++ +P+ IA+ G + +++ LL + + Q + G TAL AC + HL
Sbjct: 638 ALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQR--EAQDHEGFTALSWACLRGHLA 695
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
+ L+E G + +D G+ L AA G+ +V + ++ + D +G PL A+
Sbjct: 696 AAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAI 755
Query: 183 A 183
A
Sbjct: 756 A 756
>Hs7657265 [R] KOG0508 Ankyrin repeat protein
Length = 627
Score = 53.5 bits (127), Expect = 2e-07
Identities = 40/129 (31%), Positives = 58/129 (44%), Gaps = 7/129 (5%)
Query: 75 SPVHIASSIGSVTILEKLLNH-------TVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
+P+ IA+ G ++ LL H T D +G TAL A H VV+LL
Sbjct: 48 TPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLL 107
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHG 187
V GA+V PL A G + IV L + N+ ++I +K + L A +GH
Sbjct: 108 VSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHT 167
Query: 188 DVAVTLVNK 196
DV L+ +
Sbjct: 168 DVVRYLLEQ 176
>Hs4758806 [R] KOG0504 FOG: Ankyrin repeat
Length = 500
Score = 53.5 bits (127), Expect = 2e-07
Identities = 52/200 (26%), Positives = 91/200 (45%), Gaps = 13/200 (6%)
Query: 4 DFLLHAACMNGDTEKVQQILSEFPGAV-KVKDDDGRYPLHWAVSFQQDNIIDILLSYMKK 62
D L+H A ++ + L+ P V ++++ + LH AV Q + L+ K
Sbjct: 260 DTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVL---K 316
Query: 63 IDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEP------NLDLQANN--GITALHL 114
+ D G + +H+A S + EP +LDLQ N G+ LH+
Sbjct: 317 GASRALQDRHGDTALHVACQRQSWPVPAACWKGGPEPGRGTSHSLDLQLQNWQGLACLHI 376
Query: 115 ACSKKHLNVVQLLVERGASVRIKDGL-GQLPLHRAAASGSVGIVSILCDKNSPVNIKDKN 173
A +K+ +++LL+ GA + +++G G+ LH A + G+V L + V+ + N
Sbjct: 377 ATLQKNQPLMELLLRNGADIDVQEGSSGKTALHLAVETQERGLVQFLLQAGAQVDARMLN 436
Query: 174 GWSPLFHALAEGHGDVAVTL 193
G +PL A G ++ TL
Sbjct: 437 GCTPLHLAAGRGLMGISSTL 456
Score = 51.2 bits (121), Expect = 1e-06
Identities = 32/89 (35%), Positives = 51/89 (56%), Gaps = 1/89 (1%)
Query: 73 GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGA 132
G + +HIA+ + ++E LL + + ++ + ++G TALHLA + +VQ L++ GA
Sbjct: 370 GLACLHIATLQKNQPLMELLLRNGADIDVQ-EGSSGKTALHLAVETQERGLVQFLLQAGA 428
Query: 133 SVRIKDGLGQLPLHRAAASGSVGIVSILC 161
V + G PLH AA G +GI S LC
Sbjct: 429 QVDARMLNGCTPLHLAAGRGLMGISSTLC 457
>CE28922 [K] KOG0512 Fetal globin-inducing factor (contains ankyrin repeats)
Length = 231
Score = 53.5 bits (127), Expect = 2e-07
Identities = 43/146 (29%), Positives = 67/146 (45%), Gaps = 12/146 (8%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
A +G+ E V+ +L E P + +D DG LH A I+D LL + T
Sbjct: 73 AAEDGELELVKVLLEETPNLLNSRDADGYTALHRASYNNHSPIVDHLLLSGANKESKT-- 130
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKK-------HLN 122
GW+P+ AS+ + ++ +LL+H + N +N +TALHLA + + ++
Sbjct: 131 -NEGWTPLLSASNWANFEVVGRLLSHGSDVN--ALSNGNLTALHLAVNSRSEEPENVYMT 187
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRA 148
V LL G + G G PL A
Sbjct: 188 VRYLLQAPGIDAGVIAGNGDTPLMMA 213
>7290390 [T] KOG1217 Fibrillins and related proteins containing Ca2+-binding
EGF-like domains
Length = 2634
Score = 53.5 bits (127), Expect = 2e-07
Identities = 43/164 (26%), Positives = 75/164 (45%), Gaps = 4/164 (2%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL 93
D G LH A F + + LL + D +G +P+H A + ++ + + LL
Sbjct: 1948 DKTGETSLHLAARFARADAAKRLLDAGADANCQ---DNTGRTPLHAAVAADAMGVFQILL 2004
Query: 94 NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGS 153
+ NL+ + ++G T L LA +V+ L+ A + D G+ LH AAA +
Sbjct: 2005 RNRAT-NLNARMHDGTTPLILAARLAIEGMVEDLITADADINAADNSGKTALHWAAAVNN 2063
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKY 197
V+IL ++ + +D +PLF A EG + L++ +
Sbjct: 2064 TEAVNILLMHHANRDAQDDKDETPLFLAAREGSYEACKALLDNF 2107
Score = 52.0 bits (123), Expect = 7e-07
Identities = 48/183 (26%), Positives = 83/183 (45%), Gaps = 5/183 (2%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH A + +++L A +D+ GR PLH AV+ + ILL + +L+
Sbjct: 1955 LHLAARFARADAAKRLLDAGADA-NCQDNTGRTPLHAAVAADAMGVFQILLRN-RATNLN 2012
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ + G +P+ +A+ + ++E L+ T + +++ N+G TALH A + + V +
Sbjct: 2013 ARMHD-GTTPLILAARLAIEGMVEDLI--TADADINAADNSGKTALHWAAAVNNTEAVNI 2069
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ A+ +D + PL AA GS L D + I D P A H
Sbjct: 2070 LLMHHANRDAQDDKDETPLFLAAREGSYEACKALLDNFANREITDHMDRLPRDVASERLH 2129
Query: 187 GDV 189
D+
Sbjct: 2130 HDI 2132
>Hs18593188 [R] KOG0508 Ankyrin repeat protein
Length = 1172
Score = 53.1 bits (126), Expect = 3e-07
Identities = 33/144 (22%), Positives = 69/144 (47%), Gaps = 2/144 (1%)
Query: 53 IDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITAL 112
+D++ S +++ + +P+ A G + ++ L+ + NL++ +G L
Sbjct: 600 LDVVRSLLRRGASVNCTTRTNSTPLRAACFEGLLEVVRYLVGEH-QANLEVANRHGHMCL 658
Query: 113 HLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDK 172
++C K H + + L+E+GA V + G LH A + S+ I+ +L + + +D
Sbjct: 659 MISCYKGHREIARYLLEQGAQVNWRSAKGNTALHNCAETSSLEILQLLLGCKASME-RDS 717
Query: 173 NGWSPLFHALAEGHGDVAVTLVNK 196
G +PL A GH ++ L+ +
Sbjct: 718 YGMTPLLPASVTGHTNIVEYLIQE 741
>Hs13129098 [R] KOG0504 FOG: Ankyrin repeat
Length = 288
Score = 53.1 bits (126), Expect = 3e-07
Identities = 45/145 (31%), Positives = 68/145 (46%), Gaps = 8/145 (5%)
Query: 40 PLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEP 99
PLH A + +++LL +++ LD + +H A+ + E LL + P
Sbjct: 56 PLHCACMVSDADCVELLLEKGAEVNA---LDGYNRTALHYAAEKDEACV-EVLLEYGANP 111
Query: 100 N-LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVS 158
N LD N T LH A K + V+ L+E GASV D PL AA G++ VS
Sbjct: 112 NALD---GNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVS 168
Query: 159 ILCDKNSPVNIKDKNGWSPLFHALA 183
IL D + V + + G +P+ +A
Sbjct: 169 ILLDYGAEVRVINLIGQTPISRLVA 193
Score = 53.1 bits (126), Expect = 3e-07
Identities = 45/144 (31%), Positives = 68/144 (46%), Gaps = 7/144 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH ACM D + V ++L E V D R LH+A + + +++LL Y
Sbjct: 57 LHCACMVSDADCV-ELLLEKGAEVNALDGYNRTALHYAAE-KDEACVEVLLEYGAN---P 111
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
LD + +P+H A+ + + LL N L NN T L A K +L V +
Sbjct: 112 NALDGNRDTPLHWAAFKNNAECVRALLESGASVNA-LDYNND-TPLSWAAMKGNLESVSI 169
Query: 127 LVERGASVRIKDGLGQLPLHRAAA 150
L++ GA VR+ + +GQ P+ R A
Sbjct: 170 LLDYGAEVRVINLIGQTPISRLVA 193
Score = 52.4 bits (124), Expect = 5e-07
Identities = 44/141 (31%), Positives = 60/141 (42%), Gaps = 8/141 (5%)
Query: 46 SFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQA 105
SF DN+ D++ D P+H A + +E LL E N L
Sbjct: 31 SFPHDNVEDLIRG-----GADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNA-LDG 84
Query: 106 NNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNS 165
N TALH A K V++L+E GA+ DG PLH AA + V L + +
Sbjct: 85 YNR-TALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGA 142
Query: 166 PVNIKDKNGWSPLFHALAEGH 186
VN D N +PL A +G+
Sbjct: 143 SVNALDYNNDTPLSWAAMKGN 163
>At4g03460 [R] KOG0504 FOG: Ankyrin repeat
Length = 637
Score = 53.1 bits (126), Expect = 3e-07
Identities = 34/104 (32%), Positives = 54/104 (51%), Gaps = 8/104 (7%)
Query: 29 AVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI-DLDTILDESGWSPVHIASSIGSVT 87
+V V DDDG +P+H AV + + IL + +K+ D +LD + +H+A+ G +
Sbjct: 302 SVYVSDDDGSFPIHMAVKY---GYVKILKAILKRCPDALELLDRENQNVLHVAAKNGKIE 358
Query: 88 ILEKLLNHTVEPNLDLQAN----NGITALHLACSKKHLNVVQLL 127
+L+ +L + N + N NG T LHLA H VV +L
Sbjct: 359 VLKFILRCCKDKNKEKLINEEDANGNTPLHLATKNWHPKVVSML 402
>At2g14250 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 192
Score = 53.1 bits (126), Expect = 3e-07
Identities = 30/99 (30%), Positives = 48/99 (48%), Gaps = 1/99 (1%)
Query: 77 VHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRI 136
V AS+ G + L+ + H ++ L +NG AL A L+V Q +++ G V
Sbjct: 28 VFSASAYGDLHQLKHFVEHNGS-SVSLPDDNGFYALQWAALNNSLHVAQYIIQHGGDVNS 86
Query: 137 KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGW 175
D + Q PLH AA GS+ + +L + + D NG+
Sbjct: 87 ADNIQQTPLHWAAVKGSIDVADLLLQHGARIEAVDVNGF 125
>7299952 [R] KOG0508 Ankyrin repeat protein
Length = 662
Score = 53.1 bits (126), Expect = 3e-07
Identities = 48/193 (24%), Positives = 86/193 (43%), Gaps = 14/193 (7%)
Query: 10 ACMNGDTEKVQQILS------EFPGAVKVKDD--DGRYPLHWAVSFQQDNIIDILLSYMK 61
+C NG + V+ +L+ E G+V + + PL A + I+ +L+
Sbjct: 46 SCRNGHYDIVEYLLTKCRANVEQVGSVSFDGEPIEDAPPLWCAAAAGHLGIVKMLVRRGA 105
Query: 62 KIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHL 121
++ T + +P+ A G I++ L++H + ++ +G T L +AC K H
Sbjct: 106 NVNSTT---RTNSTPLRAACFDGHYEIVKYLVHHGAD--FEVANRHGHTCLMIACYKGHF 160
Query: 122 NVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHA 181
+ Q L+ A V G LH A SGS+ I+ +L + +++ D G +PL A
Sbjct: 161 RIAQYLLSLNADVNRCSVKGNTALHDCAESGSLQILQLLLKHGATMDV-DYYGMTPLLAA 219
Query: 182 LAEGHGDVAVTLV 194
GH + L+
Sbjct: 220 SVTGHMPIVEHLI 232
>Hs20548307_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 633
Score = 53.1 bits (126), Expect = 3e-07
Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 10/147 (6%)
Query: 53 IDILLSYMKKIDLDTILD---ESGWSPVHIASSI-------GSVTILEKLLNHTVEPNLD 102
+D+ L +MK D LD E+ + I S++ G ++ LN E NLD
Sbjct: 309 MDLQLEWMKLEDFQKHLDGKDENFAATDAIPSNVLRDAVKNGDYITVKVALNSNEEYNLD 368
Query: 103 LQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCD 162
+ ++G+T + LA + ++++LL+ +GA V + G L AA + V+IL +
Sbjct: 369 QEDSSGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLE 428
Query: 163 KNSPVNIKDKNGWSPLFHALAEGHGDV 189
+ VN++ NG + L A G+ D+
Sbjct: 429 AGAFVNVQQSNGETALMKACKRGNSDI 455
Score = 48.5 bits (114), Expect = 8e-06
Identities = 38/129 (29%), Positives = 64/129 (49%), Gaps = 3/129 (2%)
Query: 53 IDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITAL 112
+ + L+ ++ +LD D SG + V +A++ G +L L+ + N + NG TAL
Sbjct: 355 VKVALNSNEEYNLDQE-DSSGMTLVMLAAAGGQDDLLRLLITKGAKVNG--RQKNGTTAL 411
Query: 113 HLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDK 172
A K L V +L+E GA V ++ G+ L +A G+ IV ++ + + NI K
Sbjct: 412 IHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSK 471
Query: 173 NGWSPLFHA 181
+ S L A
Sbjct: 472 HQNSALHFA 480
>At5g07840 [R] KOG0504 FOG: Ankyrin repeat
Length = 213
Score = 52.8 bits (125), Expect = 4e-07
Identities = 30/84 (35%), Positives = 47/84 (55%), Gaps = 4/84 (4%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDL--QANNGITALHLACSKKHLNVVQLL 127
D+ GW+ +HI + G + +++LL+ + N + G+T LHLA H+ V+ LL
Sbjct: 66 DDRGWTQLHIKAREGDLKAVKELLDQGADVNALACGPKSKGMTPLHLAAKGGHIEVMDLL 125
Query: 128 VERGASV--RIKDGLGQLPLHRAA 149
+ERGA++ R G PLH AA
Sbjct: 126 LERGANMEARTSGACGWTPLHAAA 149
>At4g03500 [R] KOG0504 FOG: Ankyrin repeat
Length = 652
Score = 52.8 bits (125), Expect = 4e-07
Identities = 46/179 (25%), Positives = 81/179 (44%), Gaps = 11/179 (6%)
Query: 1 MGADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYM 60
+G ++HAA + + +LS+ + ++D+ GR L + S L
Sbjct: 245 VGGRSIVHAALKANRKDILDALLSKDASLINLRDE-GRTSLSFGASIGYYQGFSYLFD-- 301
Query: 61 KKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKH 120
K D + D+ G P H+A+ G V ILE++L H E ++L +G LHLA
Sbjct: 302 KNRDKVYVSDDDGLFPTHMAAKYGHVQILEEILKHCPEA-IELLDRDGQNILHLAAKYGK 360
Query: 121 LNVVQLLV------ERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKN 173
L V++ ++ + + +D G PLH A + +VS+ + V++K +N
Sbjct: 361 LKVIKFILSCCKDKNKKKLINEQDVNGNTPLHLATINWHPKVVSMF-TWDHRVDLKKRN 418
>At3g04140 [R] KOG0504 FOG: Ankyrin repeat
Length = 656
Score = 52.8 bits (125), Expect = 4e-07
Identities = 55/201 (27%), Positives = 96/201 (47%), Gaps = 21/201 (10%)
Query: 5 FLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSF-QQDNIIDILLSY---- 59
+LL+ A GD E V+++L P V + + G + +A + + D++ +LL +
Sbjct: 104 WLLYTAASAGDLEFVKKLLERDPLLVFGEGEYGVTDILYAAARGRSDDVFRLLLDFALLP 163
Query: 60 -----MKKIDLDTILD-------ESGWSPVHIASSIGSVTILEKLL-NHTVEPNLDLQAN 106
+++ID + + + E VH A+ G V IL++LL + + L+
Sbjct: 164 ADIAGVEEIDGEKLTEKQLIVKEEMVKRGVHSAARGGHVAILDELLLANKYDAVAKLRDA 223
Query: 107 NGITALHLACSKKHLNVVQLLVERGASV-RIKDGLGQLPLHRAAASGSVGIVSILCDKNS 165
G T LH A S+ + VV+ L+ + S+ +KD G LH AA G + +V L +++
Sbjct: 224 YGSTLLHSASSRAQIQVVKYLISKYDSIMEVKDSHGNTALHIAAYKGHLDVVEALINESP 283
Query: 166 PVNIKDKNGWSPLF-HALAEG 185
P+ I NG F H + G
Sbjct: 284 PL-ISIVNGDGDTFLHTVVSG 303
>At1g03670 [R] KOG0504 FOG: Ankyrin repeat
Length = 616
Score = 52.8 bits (125), Expect = 4e-07
Identities = 45/155 (29%), Positives = 75/155 (48%), Gaps = 9/155 (5%)
Query: 84 GSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGL-GQ 142
G L K +N V+ L N G + LH+A + H+++V+ ++ ++ L G+
Sbjct: 48 GDKVSLLKRINDDVKVTQRLVDNQGNSILHIAAALGHVHIVEFIISTFPNLLQNVNLMGE 107
Query: 143 LPLHRAAASGSVGIVSIL-------CDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
LH AA +GS+ IV IL ++ + K KNG + L AL H +VA LV+
Sbjct: 108 TTLHVAARAGSLNIVEILVRFITESSSYDAFIAAKSKNGDTALHAALKGKHVEVAFCLVS 167
Query: 196 KYHALWEGETDNDDLSIDKICVDAKVKDYFLSKVE 230
H + + +ND+ S + V+A + L +E
Sbjct: 168 VKHDV-SFDKNNDEASPLYMAVEAGYHELVLKMLE 201
Score = 52.0 bits (123), Expect = 7e-07
Identities = 43/173 (24%), Positives = 84/173 (47%), Gaps = 7/173 (4%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI-- 63
++HAA + + +L + PG +++++++GR L + S I +L+ K
Sbjct: 218 VIHAAMKANRRDILGIVLRQDPGLIELRNEEGRTCLSYGASMGCYEGIRYILAEFDKAAS 277
Query: 64 DLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNV 123
L + D+ G++P+H+A+ G V I+++ L H + + +L N H+A V
Sbjct: 278 SLCYVADDDGFTPIHMAAKEGHVRIIKEFLKHCPD-SRELLNNQCQNIFHVAAIAGKSKV 336
Query: 124 VQLLVERGASVRI---KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKN 173
V+ L++ R+ +D G PLH A +V++L N +N++ N
Sbjct: 337 VKYLLKLDEGKRMMNEQDINGNTPLHLATKHRYPIVVNML-TWNDGINLRALN 388
>YGR233c_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 477
Score = 52.8 bits (125), Expect = 4e-07
Identities = 57/223 (25%), Positives = 92/223 (40%), Gaps = 36/223 (16%)
Query: 7 LHAACMNGDTEKVQQIL-SEFPGAVKVKDDDGRYPLHWAVSFQQDNII-DIL-------- 56
LH A G E V +L + V D D + PL A++ +++ D+L
Sbjct: 71 LHYAAELGKLEFVHSLLITNLLEDVDPIDSDSKTPLVLAITNNHIDVVRDLLTIGGANAS 130
Query: 57 ------LSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANN--- 107
L Y K + T + + P+++A + + LL + N D N
Sbjct: 131 PIEKPILDYSKNVISSTKVQ---FDPLNVACKFNNHDAAKLLLEIRSKQNADNAKNKSSQ 187
Query: 108 ------------GITALHLACS-KKHLNVVQLLVERGASVRIKDGLGQ-LPLHRAAASGS 153
G+ LH+ ++QLL+ GA DG + P+ A SG
Sbjct: 188 HLCQPLFKKNSTGLCTLHIVAKIGGDPQLIQLLIRYGADPNEIDGFNKWTPIFYAVRSGH 247
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
+++ L N+ ++I+D NG SPLF+AL E H DV L+ +
Sbjct: 248 SEVITELLKHNARLDIEDDNGHSPLFYALWESHVDVLNALLQR 290
>Hs22058625_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 201
Score = 52.8 bits (125), Expect = 4e-07
Identities = 44/174 (25%), Positives = 84/174 (47%), Gaps = 6/174 (3%)
Query: 10 ACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTIL 69
AC +G V +++ + + D + R L AV Q++ ILL + +
Sbjct: 28 ACAHGRPGVVADLVAR-KCQLNLTDSENRTALIKAVQCQEEVCASILLEHGAN---PNVR 83
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D G + +H A ++++ KLL + + ++ ++ +G T+L LA ++K +V L++
Sbjct: 84 DMYGNTALHYAIDNENISMARKLLAYGAD--IEARSQDGHTSLLLAVNRKKEQMVAFLLK 141
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
+ + D G+ L AA +GS +V L N V +D +GW+ +A+A
Sbjct: 142 KKPDLTAIDNFGRTALILAARNGSTSVVYQLLQHNIDVFCQDISGWTAEDYAVA 195
>Hs4557799 [T] KOG1217 Fibrillins and related proteins containing Ca2+-binding
EGF-like domains
Length = 2321
Score = 52.4 bits (124), Expect = 5e-07
Identities = 45/164 (27%), Positives = 74/164 (44%), Gaps = 4/164 (2%)
Query: 34 DDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLL 93
D G LH A + + + LL + D SG +P+H A + + + + L+
Sbjct: 1836 DRTGETALHLAARYARADAAKRLLDAGADTNAQ---DHSGRTPLHTAVTADAQGVFQILI 1892
Query: 94 NHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGS 153
+ +LD + +G TAL LA +V+ L+ A V D LG+ LH AAA +
Sbjct: 1893 RNR-STDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNN 1951
Query: 154 VGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKY 197
V L + +++D +PLF A EG + A L++ +
Sbjct: 1952 VEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHF 1995
Score = 48.1 bits (113), Expect = 1e-05
Identities = 47/184 (25%), Positives = 82/184 (44%), Gaps = 7/184 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGA-VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LH A + +++L GA +D GR PLH AV+ + IL+ + DL
Sbjct: 1843 LHLAARYARADAAKRLLDA--GADTNAQDHSGRTPLHTAVTADAQGVFQILIRN-RSTDL 1899
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQ 125
D + + G + + +A+ + ++E+L+ + N + G +ALH A + ++
Sbjct: 1900 DARMAD-GSTALILAARLAVEGMVEELIASHADVNAVDEL--GKSALHWAAAVNNVEATL 1956
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
L++ GA+ ++D + PL AA GS +L D + I D P A
Sbjct: 1957 ALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERL 2016
Query: 186 HGDV 189
H D+
Sbjct: 2017 HQDI 2020
>Hs18640738 [R] KOG0504 FOG: Ankyrin repeat
Length = 475
Score = 52.4 bits (124), Expect = 5e-07
Identities = 33/127 (25%), Positives = 63/127 (48%), Gaps = 8/127 (6%)
Query: 73 GWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACS-----KKHLNVVQLL 127
GW+P+ A+S+ + ++ LL+ + + + L ACS ++ L V+LL
Sbjct: 79 GWTPLMYAASVANAELVRVLLDRGANASFEKDKQS---ILITACSAHGSEEQILKCVELL 135
Query: 128 VERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHG 187
+ R A + P+ AA G +V++L + VN +D+NG++ L A +GH
Sbjct: 136 LSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHK 195
Query: 188 DVAVTLV 194
++ + L+
Sbjct: 196 NIVLKLL 202
>Hs18254474 [R] KOG0504 FOG: Ankyrin repeat
Length = 323
Score = 52.4 bits (124), Expect = 5e-07
Identities = 35/112 (31%), Positives = 58/112 (51%), Gaps = 3/112 (2%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
SP+H A++ G + L+ L+ V N++L N +++LH AC H+ + L+E GA V
Sbjct: 67 SPLHEAAAQGRLLALKTLIAQGV--NVNLVTINRVSSLHEACLGGHVACAKALLENGAHV 124
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
G PL A SGS V++L + + + + + SP+ A+ GH
Sbjct: 125 NGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQL-EVHLASPIHEAVKRGH 175
>Hs14249672 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 528
Score = 52.4 bits (124), Expect = 5e-07
Identities = 49/197 (24%), Positives = 88/197 (43%), Gaps = 27/197 (13%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKI--- 63
LH C++ E VQQ+L E + D + PLH A + +++++L++ +
Sbjct: 108 LHQCCIDDFREMVQQLL-EAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAV 166
Query: 64 ------------------DLDTILDESGWSP--VHIASSIGSVTILEKLLNHTVEPNLDL 103
L+T + + G + + A ++ + +L+ + + ++ DL
Sbjct: 167 NTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSR-LQAGADL 225
Query: 104 QA--NNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILC 161
A ++G T LH+A + LL+E AS+ KD G PLH AA G V +V +L
Sbjct: 226 HAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLV 285
Query: 162 DKNSPVNIKDKNGWSPL 178
+ +N K +PL
Sbjct: 286 AHGADLNAKSLMDETPL 302
Score = 50.4 bits (119), Expect = 2e-06
Identities = 60/244 (24%), Positives = 105/244 (42%), Gaps = 34/244 (13%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LL AA N D E+V+Q L + ++DG LH ++ LL I+
Sbjct: 75 LLEAAARN-DLEEVRQFLGSGVSP-DLANEDGLTALHQCCIDDFREMVQQLLEAGANINA 132
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTV------------------EPNLDL---- 103
D W+P+H A++ G + ++E L+ E LD
Sbjct: 133 ---CDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETA 189
Query: 104 QANNGITALHLACSK-----KHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVS 158
A+ GIT + ++ + L+ ++ ++ GA + G LH AAA+G +
Sbjct: 190 MADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAA 249
Query: 159 ILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKICVD 218
+L + + ++ KD++GW PL HA A V L+ + A ++ D+ +D +C D
Sbjct: 250 LLLEHRASLSAKDQDGWEPL-HAAAYWGQVPLVELLVAHGADLNAKSLMDETPLD-VCGD 307
Query: 219 AKVK 222
+V+
Sbjct: 308 EEVR 311
>CE19706 [T] KOG0195 Integrin-linked kinase
Length = 466
Score = 52.4 bits (124), Expect = 5e-07
Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 2/109 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
D+ +S +H A+ G V I E LL+ N ++ T+LHLA + H +V L+
Sbjct: 48 DDHAFSLLHWAAKGGHVAIAEMLLSRGARVNSTNMGDD--TSLHLAAAHGHRQIVVKLLS 105
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
R A V + G PLH A G I L + VN+ +K G +PL
Sbjct: 106 RKADVNATNEHGMTPLHYACFWGYEQIAEDLISCGAAVNVCNKKGMTPL 154
Score = 52.4 bits (124), Expect = 5e-07
Identities = 43/164 (26%), Positives = 79/164 (47%), Gaps = 15/164 (9%)
Query: 14 GDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESG 73
G+ +V+ L + + V DD LHWA I ++LLS +++ + D++
Sbjct: 28 GNAFQVRVWLDDHEHDLNVGDDHAFSLLHWAAKGGHVAIAEMLLSRGARVNSTNMGDDTS 87
Query: 74 WSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGAS 133
+H+A++ G I+ KLL+ + N + +G+T LH AC + + + L+ GA+
Sbjct: 88 ---LHLAAAHGHRQIVVKLLSRKADVNATNE--HGMTPLHYACFWGYEQIAEDLISCGAA 142
Query: 134 VRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSP 177
V + + G PL + +C KN+ + I ++G SP
Sbjct: 143 VNVCNKKGMTPL---------DVCQPMC-KNTILEIAQEHGQSP 176
Score = 49.7 bits (117), Expect = 3e-06
Identities = 29/98 (29%), Positives = 52/98 (52%)
Query: 98 EPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIV 157
E +L++ ++ + LH A H+ + ++L+ RGA V + LH AAA G IV
Sbjct: 41 EHDLNVGDDHAFSLLHWAAKGGHVAIAEMLLSRGARVNSTNMGDDTSLHLAAAHGHRQIV 100
Query: 158 SILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
L + + VN +++G +PL +A G+ +A L++
Sbjct: 101 VKLLSRKADVNATNEHGMTPLHYACFWGYEQIAEDLIS 138
>Hs22054847_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 324
Score = 52.4 bits (124), Expect = 5e-07
Identities = 48/179 (26%), Positives = 84/179 (46%), Gaps = 10/179 (5%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC+N E + +L++ + V+D + R PL A+ ++ +IL+
Sbjct: 3 LHGACVNSHVEVIT-LLADRKCRLDVRDSENRTPLMKALQCWREAYANILVDSGPS---P 58
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNG--ITALHLACSKKHLNVV 124
I+D G +H A +++++ KLL+ D+Q N +T L L +K+ +V
Sbjct: 59 NIVDVYGNMALHYAVYSENLSVVAKLLSR----GADIQVKNKACLTPLLLVITKRSEEIV 114
Query: 125 QLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALA 183
+ LV + AS D L A GS+ VSIL ++ + +D G + +A+A
Sbjct: 115 EFLVTKNASANAVDKFKCTALMLAVCHGSLERVSILLQQDIDICAEDMCGMTAGGYAVA 173
>Hs15718772_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 813
Score = 52.4 bits (124), Expect = 5e-07
Identities = 31/77 (40%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNH-TVEPNLDLQANNGITALHLACSKKHLNVVQLLV 128
D GW+P+H A + G + I+ LL+H + Q GIT LH A + H V +LL+
Sbjct: 400 DYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLL 459
Query: 129 ERGASVRIKDGLGQLPL 145
ERGASV ++ G PL
Sbjct: 460 ERGASVTLRTRKGLSPL 476
Score = 48.1 bits (113), Expect = 1e-05
Identities = 34/92 (36%), Positives = 46/92 (49%), Gaps = 3/92 (3%)
Query: 108 GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV 167
G T LH AC + L VQ LV +G + +D G PLH A G + IV L D + V
Sbjct: 370 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 429
Query: 168 NI---KDKNGWSPLFHALAEGHGDVAVTLVNK 196
+ + G +PL AL GH +VA L+ +
Sbjct: 430 DDPGGQGCEGITPLHDALNCGHFEVAELLLER 461
>Hs4885643 [D] KOG0515 p53-interacting protein 53BP/ASPP contains ankyrin and
SH3 domains
Length = 1005
Score = 52.0 bits (123), Expect = 7e-07
Identities = 38/140 (27%), Positives = 65/140 (46%), Gaps = 16/140 (11%)
Query: 84 GSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQL 143
G ++++++ +P+L + GITALH A H +V+ LV+ G +V D G
Sbjct: 814 GEFDLVQRIIYEVDDPSLP--NDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWT 871
Query: 144 PLHRAAASGSVGIVSILCDKNSPV---NIKDKNGWSPLFHALAEGHGDVA---------V 191
PLH AA+ +V + L + + V D + + EG+ + +
Sbjct: 872 PLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKM 931
Query: 192 TLVNK--YHALWEGETDNDD 209
++NK +ALW+ E NDD
Sbjct: 932 GIMNKGVIYALWDYEPQNDD 951
>Hs13443014 [R] KOG0504 FOG: Ankyrin repeat
Length = 262
Score = 52.0 bits (123), Expect = 7e-07
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 10/173 (5%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC+ G V+ IL + V D PL A + +++LL + + +
Sbjct: 73 LHEACLGGHLSCVK-ILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPE 131
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
+ L SP+H A+ G V + L+ + N+D + ++ T L+LAC + V+
Sbjct: 132 SDLA----SPIHEAARRGHVECVNSLIAYG--GNIDHKISHLGTPLYLACENQQRACVKK 185
Query: 127 LVERGASVRIKDGLGQ-LPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
L+E GA V G GQ PLH A + S + +L D + K+ G P+
Sbjct: 186 LLESGADV--NQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPV 236
Score = 50.4 bits (119), Expect = 2e-06
Identities = 37/123 (30%), Positives = 61/123 (49%), Gaps = 3/123 (2%)
Query: 72 SGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERG 131
S WSP+H A+ G L L++ N+ + A++ ++ LH AC HL+ V++L++ G
Sbjct: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNI-ITADH-VSPLHEACLGGHLSCVKILLKHG 92
Query: 132 ASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAV 191
A V PL A SGS V++L + V + + SP+ A GH +
Sbjct: 93 AQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVN 151
Query: 192 TLV 194
+L+
Sbjct: 152 SLI 154
>At5g13300 [T] KOG0521 Putative GTPase activating proteins (GAPs)
Length = 750
Score = 52.0 bits (123), Expect = 7e-07
Identities = 26/79 (32%), Positives = 41/79 (50%)
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
N+ + + G + LH AC K L +V+LL++ GA+V D GQ PLH G V I +
Sbjct: 644 NISPEGSGGSSLLHCACEKADLGMVELLLQYGANVNASDSSGQTPLHCCLLRGKVTIARL 703
Query: 160 LCDKNSPVNIKDKNGWSPL 178
L + + ++ G + L
Sbjct: 704 LLTRGADPEAMNREGKTAL 722
>SPBP16F5.05c [R] KOG0504 FOG: Ankyrin repeat
Length = 146
Score = 51.6 bits (122), Expect = 9e-07
Identities = 29/107 (27%), Positives = 56/107 (52%), Gaps = 4/107 (3%)
Query: 70 DESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVE 129
DE+G S +H+AS+ G + +++K++ + + ++ Q +G TA+H A H + +LL+E
Sbjct: 33 DENGNSGLHMASANGHIAVVQKIIPYLNKEVINAQNESGNTAMHWAALNGHAEICKLLLE 92
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCD----KNSPVNIKDK 172
G IK+ + P++ A ++ + D K S N D+
Sbjct: 93 AGGDPHIKNIYEKSPIYEADIRNQQKVMDLFLDFEIAKGSEENTGDE 139
>Hs4758156 [T] KOG0782 Predicted diacylglycerol kinase
Length = 1065
Score = 51.6 bits (122), Expect = 9e-07
Identities = 31/87 (35%), Positives = 49/87 (55%), Gaps = 1/87 (1%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDL-QANNGITALHLACSKKHLNVVQLLVERGAS 133
S +H A+ G+ I++ +L+H LD+ + G TALH A +++ V QLLV+ GAS
Sbjct: 961 SLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGAS 1020
Query: 134 VRIKDGLGQLPLHRAAASGSVGIVSIL 160
+R D G+ P RA +G + + L
Sbjct: 1021 LRKTDSKGKTPQERAQQAGDPDLAAYL 1047
>Hs18390335 [R] KOG0504 FOG: Ankyrin repeat
Length = 308
Score = 51.6 bits (122), Expect = 9e-07
Identities = 45/135 (33%), Positives = 67/135 (49%), Gaps = 17/135 (12%)
Query: 68 ILDESGW----SPVHIASSIGSVTILEKLLNHTVE-PNLDLQANNGITALHLACSKKHLN 122
I SGW +P+ +A+S G ++ L+ LL H + +LD++A T L A S HL+
Sbjct: 55 INSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQ---TPLFTAVSHGHLD 111
Query: 123 VVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDK-NGWS----- 176
V++L+E GAS P+ AA G+V I+ L D + N+K K W+
Sbjct: 112 CVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIAS 171
Query: 177 ---PLFHALAEGHGD 188
PL+ A GH D
Sbjct: 172 CSGPLYLAAVYGHLD 186
>CE28044 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 480
Score = 51.6 bits (122), Expect = 9e-07
Identities = 57/252 (22%), Positives = 104/252 (40%), Gaps = 34/252 (13%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LL A C D +V+++L++ + +DDG PLH I+ +LL ++
Sbjct: 61 LLEATC-RADYAEVERLLNDNANP-NLHNDDGLTPLHQCAIDDNQQIMLLLLERGANVNA 118
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTV------------------EPNLDL---- 103
D W+P+H A+ + I++ L+ E LD+
Sbjct: 119 Q---DTEQWTPLHAAACCAHINIVKILIQAGANLLAVNAEGNMPYDICDHEETLDVIESE 175
Query: 104 QANNGITALHL-----ACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVS 158
A GIT ++ A K L+ +++L ++G + + G LH A+A+G + +
Sbjct: 176 MAARGITQSYIDEMRGAPEKAMLDDMKMLHQQGRELDARAPDGSTYLHVASANGYYDVAA 235
Query: 159 ILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKICVD 218
L + I+D + W P+ A D+ + L+ +Y +T N + +D +C D
Sbjct: 236 FLLTCSVSPLIRDNDFWQPVHAAACWAQPDL-IELLCQYGGDIHAKTKNGETPMD-LCED 293
Query: 219 AKVKDYFLSKVE 230
K V+
Sbjct: 294 MSTKQVISQLVQ 305
>CE19874 [D] KOG0515 p53-interacting protein 53BP/ASPP contains ankyrin and
SH3 domains
Length = 769
Score = 51.6 bits (122), Expect = 9e-07
Identities = 47/153 (30%), Positives = 65/153 (41%), Gaps = 28/153 (18%)
Query: 89 LEKLLNHTVEPNLDL------------QANN-GITALHLACSKKHLNVVQLLVERGASVR 135
L LL+ +E LDL QAN+ GITALH A H +V+ L+E A V
Sbjct: 554 LALLLDAALEGELDLVRSSASKLTDVSQANDEGITALHNAICAGHYEIVRFLIENDADVN 613
Query: 136 IKDGLGQLPLHRAAA------------SGSVGIVSILCDKNSPVN--IKDKNGWSPLFHA 181
+D G PLH AA+ G + S L D +PV +D++G+
Sbjct: 614 AQDSDGWTPLHCAASCNNLPMVRQLVEGGGCVLASTLSDMETPVEKCEEDEDGYDGCLKY 673
Query: 182 LAEGHGDVAVTLVNKYHALWEGETD-NDDLSID 213
L+ H K +A + E D+LS D
Sbjct: 674 LSAAHNSTGSINTGKVYAAYGYEAAFEDELSFD 706
>CE11616 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 476
Score = 51.6 bits (122), Expect = 9e-07
Identities = 57/252 (22%), Positives = 104/252 (40%), Gaps = 34/252 (13%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LL A C D +V+++L++ + +DDG PLH I+ +LL ++
Sbjct: 61 LLEATC-RADYAEVERLLNDNANP-NLHNDDGLTPLHQCAIDDNQQIMLLLLERGANVNA 118
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTV------------------EPNLDL---- 103
D W+P+H A+ + I++ L+ E LD+
Sbjct: 119 Q---DTEQWTPLHAAACCAHINIVKILIQAGANLLAVNAEGNMPYDICDHEETLDVIESE 175
Query: 104 QANNGITALHL-----ACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVS 158
A GIT ++ A K L+ +++L ++G + + G LH A+A+G + +
Sbjct: 176 MAARGITQSYIDEMRGAPEKAMLDDMKMLHQQGRELDARAPDGSTYLHVASANGYYDVAA 235
Query: 159 ILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDLSIDKICVD 218
L + I+D + W P+ A D+ + L+ +Y +T N + +D +C D
Sbjct: 236 FLLTCSVSPLIRDNDFWQPVHAAACWAQPDL-IELLCQYGGDIHAKTKNGETPMD-LCED 293
Query: 219 AKVKDYFLSKVE 230
K V+
Sbjct: 294 MSTKQVISQLVQ 305
>CE02585 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 209
Score = 51.6 bits (122), Expect = 9e-07
Identities = 37/150 (24%), Positives = 68/150 (44%), Gaps = 4/150 (2%)
Query: 68 ILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLL 127
++D V A+ G V +E L + PN ++G + LH A L V +LL
Sbjct: 18 VVDSFNLHAVISATQHGHVESVEAALKQGLSPNTT--DDDGCSLLHWAAINNRLEVARLL 75
Query: 128 VERGASVRIKDG-LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
+ A + G L P+H AA +G V + ++L + N++D G++P+ A+ H
Sbjct: 76 ISYNADANLIGGVLASSPIHWAARNGLVAMCAVLVKGGAVCNVRDIQGYTPIHLAIQGNH 135
Query: 187 GDVAVTLVNKYHALWEGETDNDDLSIDKIC 216
+ + K+ + +DN ++ +C
Sbjct: 136 VPLVAYFLLKFEYA-KDISDNSGMTPAMMC 164
>7299262 [E] KOG0503 Asparaginase
Length = 605
Score = 51.6 bits (122), Expect = 9e-07
Identities = 47/165 (28%), Positives = 70/165 (41%), Gaps = 6/165 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
+H AC G V ++S V V D R PLH A+ +II+ LL K++
Sbjct: 441 MHLACFLGKLNCVCFLISA-GCPVNVHDRFNRTPLHEAIDTDNHDIINALLKNGAKLNDQ 499
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
++ + + G + LE NL L G TALH AC + VV
Sbjct: 500 PLVQAE---LLRALTERGKIKRLESF--RLAGANLTLADRTGRTALHYACQLGNHEVVDY 554
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKD 171
L+ + IKD LG P+ A A+ I++++ K + KD
Sbjct: 555 LLPHYENPYIKDELGMSPIDYAKAANHAHILTLMRFKEKELAKKD 599
>YIR033w [K] KOG3836 HLH transcription factor EBF/Olf-1 and related DNA
binding proteins
Length = 1113
Score = 51.2 bits (121), Expect = 1e-06
Identities = 28/89 (31%), Positives = 47/89 (52%)
Query: 86 VTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPL 145
V I + + + + N+ + + G T LHLAC K + ++V L+++GA V D G PL
Sbjct: 698 VLIQKVIKSLNINSNISICDSLGRTLLHLACLKNYSSLVYTLIKKGARVNDIDSFGLTPL 757
Query: 146 HRAAASGSVGIVSILCDKNSPVNIKDKNG 174
H A SG I+ +L + +++ NG
Sbjct: 758 HFACISGDPKIIKMLLNCKVNYSLRSHNG 786
>Hs14149971 [R] KOG0504 FOG: Ankyrin repeat
Length = 823
Score = 51.2 bits (121), Expect = 1e-06
Identities = 44/159 (27%), Positives = 69/159 (42%), Gaps = 2/159 (1%)
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
+S +H A+ G +E+ L +LD TALHLAC+ H+ VV LLV R
Sbjct: 31 DSELQKIHRAAVKGDAAEVERCLARR-SGDLDALDKQHRTALHLACASGHVQVVTLLVNR 89
Query: 131 GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVA 190
+ + D + PL +A IL + + N KD G + L +A+ +A
Sbjct: 90 KCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNFKDIYGNTALHYAVYSESTSLA 149
Query: 191 VTLVNK-YHALWEGETDNDDLSIDKICVDAKVKDYFLSK 228
L++ H + +N L IC K+ ++ L K
Sbjct: 150 EKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKK 188
Score = 48.9 bits (115), Expect = 6e-06
Identities = 44/177 (24%), Positives = 74/177 (40%), Gaps = 7/177 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
+H A + GD +V++ L+ G + D R LH A + ++ +L++ +ID
Sbjct: 37 IHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQID-- 94
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNL-DLQANNGITALHLACSKKHLNVVQ 125
+ D+ +P+ A LL H PN D+ N TALH A + ++ +
Sbjct: 95 -VCDKENRTPLIQAVHCQEEACAVILLEHGANPNFKDIYGN---TALHYAVYSESTSLAE 150
Query: 126 LLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHAL 182
L+ GA + D PL A +V L K + + D+ S L A+
Sbjct: 151 KLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKKKASSHAVDRLRRSALMLAV 207
>Hs13375989 [R] KOG0504 FOG: Ankyrin repeat
Length = 278
Score = 51.2 bits (121), Expect = 1e-06
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 7/162 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
+H A G++ ++QQ++ E V D PLH A Q + +LL+ ++D
Sbjct: 23 VHEAAQRGESLQLQQLI-ESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDAR 81
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
I G +P+ A + GS+ ++ L++ + N L + LH AC V+L
Sbjct: 82 NI---DGSTPLCDACASGSIECVKLSLSYGAKVNPPLYT---ASPLHEACMSGSSECVRL 135
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN 168
L++ GA++ D PLH A A + V +L + + VN
Sbjct: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN 177
>7304080 [R] KOG0504 FOG: Ankyrin repeat
Length = 453
Score = 51.2 bits (121), Expect = 1e-06
Identities = 46/161 (28%), Positives = 72/161 (44%), Gaps = 13/161 (8%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQ------DNIIDILLSY 59
LL AC G + V+ +L E GA + D PL A + + I+ +LL +
Sbjct: 77 LLMLACREGHYKIVEWLL-ERAGANVNRQLDSLMPLMMACNTTHKDPCLAERIVGLLLRH 135
Query: 60 MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKK 119
I++ ++ G +P A G ++ L+ + + D N G TA+ A K
Sbjct: 136 GAVINVS---EKYGMTPFMFACQNGFAGVVRLLIK---DASFDAVDNQGCTAIFHAIEKN 189
Query: 120 HLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
H+ VV+LLVE GA+ I + G P A G ++ IL
Sbjct: 190 HVEVVKLLVEAGANATIANNKGYTPTQVAECHGYYDLLEIL 230
>At5g20350 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 592
Score = 50.8 bits (120), Expect = 2e-06
Identities = 44/189 (23%), Positives = 81/189 (42%), Gaps = 6/189 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
++ A GD EK+ +++ +V D G Y L W+ + + L+ + ++
Sbjct: 35 VYTAAAYGDLEKLHRLVECEGSSVSEPDALGYYALQWSALNNRVAVAQYLIEHGGDVNAT 94
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
D +G + +H ++ G++ + E LL +D G A H+A +
Sbjct: 95 ---DHTGQTALHWSAVRGAIQVAELLLQEGAR--VDATDMYGYQATHVAAQYGQTAFLCH 149
Query: 127 LVER-GASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEG 185
+V + A + D G+ PLH AA G + +L ++ +DK G +PL A G
Sbjct: 150 VVSKWNADPDVPDNDGRSPLHWAAYKGFADSIRLLLFLDAYRGRQDKEGCTPLHWAAIRG 209
Query: 186 HGDVAVTLV 194
+ + LV
Sbjct: 210 NLEACTVLV 218
>At4g14390 [R] KOG0504 FOG: Ankyrin repeat
Length = 691
Score = 50.8 bits (120), Expect = 2e-06
Identities = 43/130 (33%), Positives = 68/130 (52%), Gaps = 17/130 (13%)
Query: 82 SIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLV-ERGASVRIKDGL 140
S G+ LEKL + + +++N G + LHLA + HL +V+ +V E + ++
Sbjct: 107 SDGNKECLEKLRSRGISV-ARIKSNTGDSILHLAVTWGHLELVKEIVCECPRLLLEQNSS 165
Query: 141 GQLPLHRAAASGSVGIVSI-----------LCDKNS----PVNIKDKNGWSPLFHALAEG 185
GQ PLH AA SG IV LC++ S P +KDK+G + L++A+
Sbjct: 166 GQTPLHVAAHSGHTTIVEAFVALVTFSSARLCNEESERMNPYVLKDKDGNTALYYAIEGR 225
Query: 186 HGDVAVTLVN 195
+ ++AV LVN
Sbjct: 226 YFEMAVCLVN 235
>Hs20478597 [O] KOG4412 26S proteasome regulatory complex subunit PSMD10
Length = 283
Score = 50.4 bits (119), Expect = 2e-06
Identities = 29/80 (36%), Positives = 40/80 (49%), Gaps = 2/80 (2%)
Query: 71 ESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVER 130
++GWSP+H +S G I++ LL + N Q NG T LH SK +V L+E
Sbjct: 54 DTGWSPLHTVASAGRDEIVKALLGKCAQVNAVSQ--NGCTPLHYTASKNRNEIVVKLLEG 111
Query: 131 GASVRIKDGLGQLPLHRAAA 150
G +D +HRAAA
Sbjct: 112 GVDPHAEDHCEATAMHRAAA 131
>CE08106 [T] KOG0507 CASK-interacting adaptor protein (caskin) and related
proteins with ankyrin repeats and SAM domain
Length = 1125
Score = 50.1 bits (118), Expect = 3e-06
Identities = 48/176 (27%), Positives = 76/176 (42%), Gaps = 24/176 (13%)
Query: 10 ACMNGDTEKVQQILSEFPGA------------------VKVKDDDGRYPL-HWAVSFQQD 50
AC G+ +KV LS G KD+ + L H AV Q+
Sbjct: 16 ACKKGEYDKVALFLSSKKGKKIRSGLKFFTTRSDSHWLADYKDEKSDFTLLHHAVLENQN 75
Query: 51 NIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGI- 109
I +L+ Y + L P+H+A+ G++ I++ LL T+E D+ I
Sbjct: 76 QISKLLMDYEPLLLL--CKSTKNILPIHLAAWNGNLEIVKMLLLQTMEKPADILNAVNIF 133
Query: 110 --TALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDK 163
T LHLA + HL VV L+++ A I++ + + A+ GS + +LC K
Sbjct: 134 NETPLHLAVQRCHLEVVFYLIKKNADPFIRNENKENVIDVASRIGSAEAIRMLCQK 189
>At2g17390 [R] KOG0504 FOG: Ankyrin repeat
Length = 344
Score = 50.1 bits (118), Expect = 3e-06
Identities = 37/119 (31%), Positives = 55/119 (46%), Gaps = 2/119 (1%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
S VH +S+G V L+ L N D + + G TALH AC + Q+L++ GA+
Sbjct: 222 SIVHQTASLGDVEGLKAAL--ASGGNKDEEDSEGRTALHFACGYGEVRCAQVLLDAGANA 279
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTL 193
D PLH AA G VS+L + + V ++ + +P+ A DV L
Sbjct: 280 NAIDKNKNTPLHYAAGYGRKECVSLLLENGAAVTQQNMDNKNPIDVARLNNQLDVVKLL 338
>7303116 [R] KOG0514 Ankyrin repeat protein
Length = 1224
Score = 50.1 bits (118), Expect = 3e-06
Identities = 47/172 (27%), Positives = 83/172 (47%), Gaps = 14/172 (8%)
Query: 30 VKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTIL 89
V + D +G +H+AVS +++ ILL K D++ ++ +G++ V + S + L
Sbjct: 1025 VNLSDSNGNTAMHYAVSHGNFDVVSILLD-SKVCDVNQ-MNNAGYTSVMLVS----LAKL 1078
Query: 90 EKLLNHTVEPNLDLQANNGI-------TALHLACSKKHLNVVQLLVERGASVRIKDGLGQ 142
++ + TV L A+ I TAL LA S + ++V +L++ GA + I+D G
Sbjct: 1079 KQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGS 1138
Query: 143 LPLHRAAASGSVGIVS-ILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTL 193
L AA G V ++ +L + D +G + A GH DV + +
Sbjct: 1139 TALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLI 1190
>YPL239w [R] KOG0504 FOG: Ankyrin repeat
Length = 200
Score = 49.7 bits (117), Expect = 3e-06
Identities = 38/155 (24%), Positives = 69/155 (44%), Gaps = 16/155 (10%)
Query: 69 LDESGWSPVHIASSIGSVTILEKLLNHTVEPNL---DLQANNGITALHLACSKKHLNVVQ 125
LD+ + + + G + L+ + V P L ++ + TALH+A + H+ V+
Sbjct: 8 LDQEDQDTIILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVR 67
Query: 126 LLVERGASVRIKDGL----------GQLPLHRAAASGSVGIVSILCDK-NSPVNIKDKNG 174
++E + + L G LH A+ +G + +V +LCD+ + I++K G
Sbjct: 68 YILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNKFG 127
Query: 175 WSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDD 209
+F A G +V + KY E E D +D
Sbjct: 128 HDAIFEAENSGKEEVETYFLKKYDV--EPEDDEED 160
>CE27420 [R] KOG0504 FOG: Ankyrin repeat
Length = 510
Score = 49.7 bits (117), Expect = 3e-06
Identities = 51/198 (25%), Positives = 91/198 (45%), Gaps = 12/198 (6%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRY-PLHWAVSFQQDNIIDILLSYMKKID 64
+L AA GDT+ +L +F A+ + D++ + P+H A + Q NI + +
Sbjct: 141 ILMAATARGDTDMSIWLLRKFGKALALLDNNCKMLPVHVAAA--QGNIEFLRAAIKFDNQ 198
Query: 65 LDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVV 124
+ DE G +P A G + + + L + +N G + LH+AC H ++V
Sbjct: 199 MVNARDEFGCTPCVYAVQGGCLGTV-RFLVEKARSEMGSVSNRGQSLLHIACLCGHEHIV 257
Query: 125 QLLVERGASVRIKDGLGQL--PLHRAAASGSVGIVSILCD------KNSPVNIKDKNGWS 176
+ ++ R S I +H AA SGSV ++S L + ++ + ++D G +
Sbjct: 258 RWILNRSGSDAILWTTNDRANAIHCAAYSGSVPVLSHLLNAFSKKKRHYVMTLRDTRGNT 317
Query: 177 PLFHALAEGHGDVAVTLV 194
PL A H D A+ ++
Sbjct: 318 PLHLAAMNNHLDAALYML 335
>At4g03470 [R] KOG0504 FOG: Ankyrin repeat
Length = 683
Score = 49.7 bits (117), Expect = 3e-06
Identities = 39/150 (26%), Positives = 67/150 (44%), Gaps = 6/150 (4%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMK 61
G +L HAA + T+ + IL+E+P V +D++GR L + S + LL+ +
Sbjct: 269 GRKYLAHAALNSLSTDILDVILNEYPSLVDERDEEGRTCLSFGASIGYHKGVCNLLNRSR 328
Query: 62 KIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHL 121
K + D+ G P+H+A G + +++++ L L G LH+A
Sbjct: 329 KGVF--VCDDDGSYPIHLAVEKGRIKVVKEICKRCPYSKL-LLNKKGQNLLHIAAESGKF 385
Query: 122 NVVQLLVERGASVRI---KDGLGQLPLHRA 148
+++ L + KD G PLH A
Sbjct: 386 RILRHLTAHEQINHLANEKDVDGNTPLHLA 415
Score = 48.1 bits (113), Expect = 1e-05
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 17/152 (11%)
Query: 60 MKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKK 119
+K DL + E + S++G+ LEKL +H P L+ + G + LHLA +
Sbjct: 72 LKFSDLFDLPGEYVLMNAEMLSTLGNEEWLEKLRSHGT-PLTCLKNDRGDSVLHLAATWS 130
Query: 120 HLNVVQLLVERGASVRIK-DGLGQLPLHRAAASGSVGIVSILC-------------DKN- 164
HL +V+ +V + + ++ + QLPLH AA G + +V L D+
Sbjct: 131 HLELVKNIVSECSCLLMESNSKDQLPLHVAARMGHLAVVEDLVASVTFFSARLAEEDREI 190
Query: 165 -SPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
+P +KD NG + L AL + +VA+ LVN
Sbjct: 191 LNPYLLKDINGDTALNLALKGHYTEVALCLVN 222
>At3g09550 [R] KOG0504 FOG: Ankyrin repeat
Length = 436
Score = 49.7 bits (117), Expect = 3e-06
Identities = 33/92 (35%), Positives = 50/92 (53%), Gaps = 2/92 (2%)
Query: 107 NGITALHLACSKKHLNVVQLLVERGASV-RIKDGLGQLPLHRAAASGSVGIVSILCDKNS 165
+G ALH+ACS+ H ++VQLL+E + + PL AA G +V+ L K+S
Sbjct: 6 SGFDALHIACSQGHRSIVQLLLEHEPQLSKTVAQSNATPLVSAATRGHSEVVNELLAKDS 65
Query: 166 PV-NIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
+ I NG + L A +GH D+ TL++K
Sbjct: 66 SLLEISRSNGKNALHLAARQGHVDIVRTLLDK 97
Score = 49.7 bits (117), Expect = 3e-06
Identities = 44/126 (34%), Positives = 63/126 (49%), Gaps = 6/126 (4%)
Query: 72 SGWSPVHIASSIGSVTILEKLLNHTVEPNLD-LQANNGITALHLACSKKHLNVV-QLLVE 129
SG+ +HIA S G +I++ LL H EP L A + T L A ++ H VV +LL +
Sbjct: 6 SGFDALHIACSQGHRSIVQLLLEH--EPQLSKTVAQSNATPLVSAATRGHSEVVNELLAK 63
Query: 130 RGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIK-DKNGWSPLFHALAEGHGD 188
+ + I G+ LH AA G V IV L DK+ + + DK G + L H +G
Sbjct: 64 DSSLLEISRSNGKNALHLAARQGHVDIVRTLLDKDPQLARRTDKKGQTSL-HMAVKGVSS 122
Query: 189 VAVTLV 194
V L+
Sbjct: 123 QVVRLL 128
Score = 48.9 bits (115), Expect = 6e-06
Identities = 47/156 (30%), Positives = 69/156 (44%), Gaps = 6/156 (3%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
LH AC G VQ +L P K PL A + +++ LL+ K L
Sbjct: 11 LHIACSQGHRSIVQLLLEHEPQLSKTVAQSNATPLVSAATRGHSEVVNELLA--KDSSLL 68
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQAN-NGITALHLACSKKHLNVVQ 125
I +G + +H+A+ G V I+ LL+ +P L + + G T+LH+A VV+
Sbjct: 69 EISRSNGKNALHLAARQGHVDIVRTLLDK--DPQLARRTDKKGQTSLHMAVKGVSSQVVR 126
Query: 126 LLVERG-ASVRIKDGLGQLPLHRAAASGSVGIVSIL 160
LL+ A V + D G LH A IV+ L
Sbjct: 127 LLLRADPAIVMLPDKFGNTVLHIATRKKRAEIVNEL 162
>7303699 [R] KOG0504 FOG: Ankyrin repeat
Length = 921
Score = 49.7 bits (117), Expect = 3e-06
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 10/145 (6%)
Query: 29 AVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLDTILDESGWSPVHIASSIGSVTI 88
A+ + +++G LH A + LL + D D + + G +P+H A G +
Sbjct: 117 ALGIANNEGLSALHLAAQNGHNQSSRELL--LAGADPD-VRNNYGDTPLHTACRYGHAGV 173
Query: 89 LEKLLNHTVEPNLDLQAN-NGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHR 147
LL+ +PN + N NG TALH+ C+ + ++L+E A + IK+ G P+H
Sbjct: 174 SRILLSALCDPN---KTNLNGDTALHITCAMGRRKLTRILLEADARLGIKNAQGDCPMHI 230
Query: 148 AAASGSVGIVSILCDKNSPVNIKDK 172
A I+ IL N+P I+++
Sbjct: 231 AIRKNYREIIEIL---NTPKKIRNR 252
>7294202 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 637
Score = 49.7 bits (117), Expect = 3e-06
Identities = 49/176 (27%), Positives = 82/176 (45%), Gaps = 8/176 (4%)
Query: 6 LLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDL 65
LLH A +N + ++ L + V + PLHWA +Q ++ ++L D
Sbjct: 81 LLHWAAINNRRDIIRYFLEKGATVDAVGGELNATPLHWAT--RQGHLGAVVLLMAAGAD- 137
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKK-HLNVV 124
I D G S +HIA+ ++ + V+P DLQ G+TAL A K L+ V
Sbjct: 138 PRIRDAEGCSCIHIAAQFAHTALVAYFIAKGVDP--DLQDRGGMTALMWAAWKVCALDPV 195
Query: 125 QLLVERGASVRIKDGL-GQLPLHRA-AASGSVGIVSILCDKNSPVNIKDKNGWSPL 178
+LL+ GA+ + D G LH A A + I +++ + +++ + G +PL
Sbjct: 196 RLLLTLGANPAMVDYTHGNTALHWAILARNATAISTLVLKSKASLDVPNLRGETPL 251
>Hs7706379 [R] KOG0504 FOG: Ankyrin repeat
Length = 426
Score = 49.3 bits (116), Expect = 4e-06
Identities = 35/120 (29%), Positives = 56/120 (46%), Gaps = 4/120 (3%)
Query: 55 ILLSYMKKIDLDTILDESGWSP-VHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALH 113
+L SY + L + +S W+ +H++ G V L LL+H N NG T LH
Sbjct: 56 VLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINC---RPNGKTPLH 112
Query: 114 LACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKN 173
+AC +++ V++L +RGA + G LH S+ L + + VN+K N
Sbjct: 113 VACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNN 172
>Hs22044723 [R] KOG0504 FOG: Ankyrin repeat
Length = 119
Score = 49.3 bits (116), Expect = 4e-06
Identities = 30/98 (30%), Positives = 51/98 (51%)
Query: 100 NLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSI 159
++D + N +TAL +A + V+ +++R +V + D G L A+ G IV
Sbjct: 4 DVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQD 63
Query: 160 LCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKY 197
L D + VNI D++G + L A+ GH ++ L+ KY
Sbjct: 64 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKY 101
>At3g02850 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 828
Score = 49.3 bits (116), Expect = 4e-06
Identities = 49/180 (27%), Positives = 85/180 (47%), Gaps = 8/180 (4%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMKKIDLD 66
L++A GD +++ ++ G D DGR PLH A S ++I L+ + +D++
Sbjct: 552 LNSAAFYGDLYQLKSLIRA-GGDPNKTDYDGRSPLHLAASRGYEDITLYLIQ--ESVDVN 608
Query: 67 TILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQL 126
I D+ G +P+ A G+ + L+ N++ N T L +K + ++
Sbjct: 609 -IKDKLGSTPLLEAIKNGNDRVAALLVKEGATLNIE----NAGTFLCTVVAKGDSDFLKR 663
Query: 127 LVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
L+ G KD + PLH AA+ G + L + ++ V KD+ G +PL AL G+
Sbjct: 664 LLSNGIDPNSKDYDHRTPLHVAASEGFYVLAIQLVEASANVLAKDRWGNTPLDEALGCGN 723
>7295521_2 [I] KOG0817 Acyl-CoA-binding protein
Length = 231
Score = 49.3 bits (116), Expect = 4e-06
Identities = 34/119 (28%), Positives = 59/119 (49%), Gaps = 19/119 (15%)
Query: 75 SPVHIASSIGSVTILEK-------LLNHTVEPNLD-----LQANN-------GITALHLA 115
+P + SI SV + ++ L +H E NLD LQ ++ G+ +H A
Sbjct: 85 NPGWVVHSIESVPLEDQRLDSEKTLFDHVKENNLDRLRELLQPSDLVKLDEHGMALIHWA 144
Query: 116 CSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNG 174
+ + ++Q LV GASV +D Q PLH AA+ G + + L + ++ + ++D +G
Sbjct: 145 TDRNAVEIIQFLVRSGASVNQRDAEQQTPLHYAASCGHLEALQCLLELHASLELRDSDG 203
>Hs22059561 [R] KOG0504 FOG: Ankyrin repeat
Length = 301
Score = 48.9 bits (115), Expect = 6e-06
Identities = 37/130 (28%), Positives = 65/130 (49%), Gaps = 5/130 (3%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG 139
A+ G++ +L+ LLN + ++D + ++G T L +A H++ V+ LV +GA + ++
Sbjct: 19 AARRGNLALLKLLLN-SGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77
Query: 140 LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV----N 195
G L AA G +V L + + K+G + L A GH V TL+ N
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
Query: 196 KYHALWEGET 205
+ L++G T
Sbjct: 138 IHDQLYDGAT 147
>Hs18129634 [M] KOG4177 Ankyrin
Length = 337
Score = 48.9 bits (115), Expect = 6e-06
Identities = 31/106 (29%), Positives = 50/106 (46%)
Query: 105 ANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKN 164
+ AL++A + H + VQ L+E GAS + LG+ PLH AAA G + +L
Sbjct: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
Query: 165 SPVNIKDKNGWSPLFHALAEGHGDVAVTLVNKYHALWEGETDNDDL 210
+ ++ +D G +P+ A H +V + G D +DL
Sbjct: 269 ASIHDRDAKGETPISIAHRLNHTLSERQMVLLHRIAKSGIRDLNDL 314
>At5g51160 [R] KOG0504 FOG: Ankyrin repeat
Length = 442
Score = 48.9 bits (115), Expect = 6e-06
Identities = 36/125 (28%), Positives = 66/125 (52%), Gaps = 2/125 (1%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNII-DILLSYMKKIDL 65
LHAA G E V+ L ++KD DG+ PLH A + ++I +I+ S + ++
Sbjct: 51 LHAAAAAGQVETVRATLGVEKKLCRLKDRDGKTPLHVATMRGKIDVIREIVASCVDCLED 110
Query: 66 DTILDESGWSPVHIASSIGSVTILEKLLNHTVEPN-LDLQANNGITALHLACSKKHLNVV 124
+T+ ++ + I +V + +L+ T + L+ + G TALHLA +K+ V+
Sbjct: 111 ETVQGQTALHLAVLHLEIEAVIAIVELITETNRFDVLNKKDEQGNTALHLATWRKNRQVI 170
Query: 125 QLLVE 129
++LV+
Sbjct: 171 EVLVQ 175
>At5g50140 [R] KOG0504 FOG: Ankyrin repeat
Length = 535
Score = 48.9 bits (115), Expect = 6e-06
Identities = 41/169 (24%), Positives = 69/169 (40%), Gaps = 15/169 (8%)
Query: 7 LHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILL--------- 57
LH A G+ E V++I+ P V + PLH A +I+ ++L
Sbjct: 31 LHLAVKLGNEELVKKIVEIHPSLVSSTNTKSDTPLHLAARLGHTSILLLMLESTAESIES 90
Query: 58 ---SYMKKIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHL 114
+ + L ++++ G++P+H A GSV L +N + T HL
Sbjct: 91 LEETVPNDLKLAEMVNKDGFTPLHCAVMNGSVETLTAFINKAPLSFDSVTLQTSETVFHL 150
Query: 115 ACSKKHLNVVQLLVERGASVRI---KDGLGQLPLHRAAASGSVGIVSIL 160
A K + + + R+ DG G LH AA+ G + +VS +
Sbjct: 151 AARHKKMEAFIFMAKNANLRRLLYELDGEGNTVLHAAASVGFLSLVSYI 199
>At4g03480 [R] KOG0504 FOG: Ankyrin repeat
Length = 617
Score = 48.9 bits (115), Expect = 6e-06
Identities = 48/186 (25%), Positives = 80/186 (42%), Gaps = 12/186 (6%)
Query: 2 GADFLLHAACMNGDTEKVQQILSEFPGAVKVKDDDGRYPLHWAVSFQQDNIIDILLSYMK 61
G LLHAA +T+ + IL++ P V +D++GR L S I LL
Sbjct: 313 GRKSLLHAALKAKNTDVLNVILNDDPSLVNERDEEGRTCLSVGASMGYYKGICKLLDRST 372
Query: 62 KIDLDTILDESGWSPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKH- 120
K + D+ G P+H+A G + +++++L + + +L G LH+A
Sbjct: 373 KSVYE--CDKDGSFPIHMAVEKGHLKVVKEILKRCPD-SKELVNKQGQNMLHIAAKSAKV 429
Query: 121 ----LNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILC----DKNSPVNIKDK 172
L ++ L + +D G PLH A + V L + +NI++K
Sbjct: 430 GSFLLGYIRRLDTENHLIEEQDVDGNAPLHLATINWRCRTVDKLAAFASTETKILNIQNK 489
Query: 173 NGWSPL 178
+G PL
Sbjct: 490 DGLRPL 495
>At1g60860 [T] KOG0521 Putative GTPase activating proteins (GAPs)
Length = 776
Score = 48.9 bits (115), Expect = 6e-06
Identities = 25/78 (32%), Positives = 43/78 (55%)
Query: 108 GITALHLACSKKHLNVVQLLVERGASVRIKDGLGQLPLHRAAASGSVGIVSILCDKNSPV 167
G + LH+AC +++LL++ GA + ++D G+ PLH ASG+ +L + +
Sbjct: 684 GCSLLHVACQSGDPILLELLLQFGADINMRDYHGRTPLHHCIASGNNAFAKVLLRRGARP 743
Query: 168 NIKDKNGWSPLFHALAEG 185
+I+D G S L A+ G
Sbjct: 744 SIEDGGGLSVLERAMEMG 761
>Hs4502751 [R] KOG0504 FOG: Ankyrin repeat
Length = 168
Score = 48.5 bits (114), Expect = 8e-06
Identities = 43/134 (32%), Positives = 65/134 (48%), Gaps = 8/134 (5%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDG 139
A++ G + L LL + V N++ Q G TAL + + + + L+ RGA+ +KD
Sbjct: 12 AAARGDLEQLTSLLQNNV--NVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDR 68
Query: 140 LGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLV----- 194
G +H AA +G + + L + + VNI+D G PL A EGH V LV
Sbjct: 69 TGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS 128
Query: 195 NKYHALWEGETDND 208
N H +G+T D
Sbjct: 129 NVGHRNHKGDTACD 142
>Hs22057484 [R] KOG0504 FOG: Ankyrin repeat
Length = 324
Score = 48.5 bits (114), Expect = 8e-06
Identities = 37/125 (29%), Positives = 55/125 (43%), Gaps = 4/125 (3%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKK----HLNVVQLLVERGASVR 135
A G V + +L+ +D +A G T L +A V+LL+E+GA+V
Sbjct: 19 AMQAGKVHLARFVLDALDRSIIDCRAEQGRTPLMVAVGLPDPALRARFVRLLLEQGAAVN 78
Query: 136 IKDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVN 195
++D G+ L A G + V +L + D G SP+ A A GHG V LV
Sbjct: 79 LRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
Query: 196 KYHAL 200
+ L
Sbjct: 139 SFRRL 143
>7291268 [D] KOG0515 p53-interacting protein 53BP/ASPP contains ankyrin and
SH3 domains
Length = 1071
Score = 48.5 bits (114), Expect = 8e-06
Identities = 30/87 (34%), Positives = 47/87 (53%), Gaps = 4/87 (4%)
Query: 80 ASSIGSVTILEKLLNHTVEPNLDLQANN-GITALHLACSKKHLNVVQLLVERGASVRIKD 138
AS G + +++K P+ AN+ GITALH A H+++V+ LVE G V +D
Sbjct: 872 ASLEGELELVKKTAMQVANPSA---ANDEGITALHNAICAGHIDIVKFLVEFGCDVNAQD 928
Query: 139 GLGQLPLHRAAASGSVGIVSILCDKNS 165
G PLH AA+ ++ +V L + +
Sbjct: 929 SDGWTPLHCAASCNNLSMVKFLVESGA 955
>At4g19150 [R] KOG0504 FOG: Ankyrin repeat
Length = 249
Score = 48.1 bits (113), Expect = 1e-05
Identities = 32/101 (31%), Positives = 47/101 (45%), Gaps = 2/101 (1%)
Query: 77 VHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRI 136
+H+A+ G ++ L + + + A + + A+H A K HL VV+ L+ G SV+
Sbjct: 60 LHLAAWAGHNEVVSYLCKNKAD--VGAAAGDDMGAIHFASQKGHLEVVRTLLSAGGSVKS 117
Query: 137 KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSP 177
G PLH AA IV L K + V K G SP
Sbjct: 118 ITRKGLTPLHYAAQGSHFEIVKYLVKKGASVRATTKAGKSP 158
>At1g10340 [R] KOG0504 FOG: Ankyrin repeat
Length = 578
Score = 48.1 bits (113), Expect = 1e-05
Identities = 44/163 (26%), Positives = 76/163 (45%), Gaps = 15/163 (9%)
Query: 75 SPVHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASV 134
+P+H+A+ +G V I+ ++L +E NN T LHLAC + +L+ E+ S+
Sbjct: 73 TPLHLAAILGDVNIVMQMLETGLEVCSARNINNH-TPLHLACRSNSIEAARLIAEKTQSI 131
Query: 135 RIKDGLGQLPLHRAAASGSVGIVSILCDKNSPVN------IKDKNGWSPLFHALAEGHGD 188
GLG+L L A +SGS IV + ++ + ++D + + L HA +G +
Sbjct: 132 ----GLGELIL--AISSGSTSIVGTILERFPDLAREEAWVVEDGSQSTLLHHACDKGDFE 185
Query: 189 VAVTLVNKYHALWEGETDN--DDLSIDKICVDAKVKDYFLSKV 229
+ L+ L E N L + + + + FL KV
Sbjct: 186 LTTILLGLDQGLEEALNPNGLSPLHLAVLRGSVVILEEFLDKV 228
>SPAPB1E7.05_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 724
Score = 48.1 bits (113), Expect = 1e-05
Identities = 45/164 (27%), Positives = 77/164 (46%), Gaps = 20/164 (12%)
Query: 40 PLHWAVSFQQD-------------NIIDILLSYMKKIDLDTILDESG-WSPVHIASSIGS 85
PL+W + +D N ++ L + + D +T + G P+ + +G
Sbjct: 286 PLNWMLPCWRDVMHDTPLTLAIKGNHVEALHALLSAQDKETTSTKPGPVPPLVLTCCVGD 345
Query: 86 VT-ILEKLLNHTVEPN-LDLQANNGITALHLACSKKHLNVVQLLVERGASVRIKDGLGQ- 142
I+E+L+ PN +D +N TALH A V++L++ GA+ +D L
Sbjct: 346 YDLIVEELILAGFNPNEVDASSN---TALHTAVRYNRPECVKMLLKLGANPSARDFLNSW 402
Query: 143 LPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGH 186
PL A+A+G IVSIL + V+ D +GW+ + A+ G+
Sbjct: 403 TPLMLASATGLSEIVSILVASGASVDEVDSSGWTAMEQAVVRGY 446
>Hs22045770_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 817
Score = 48.1 bits (113), Expect = 1e-05
Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 2/123 (1%)
Query: 77 VHIASSIGSVTILEKLLNHTVEPNLDLQANNGITALHLACSKKHLNVVQLLVERGASVRI 136
+H A+ G +E+ L +LD + T LHLAC+ + VV LL+ R + I
Sbjct: 38 IHRAAIKGDAAEVERCLTRRFR-DLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDI 96
Query: 137 KDGLGQLPLHRAAASGSVGIVSILCDKNSPVNIKDKNGWSPLFHALAEGHGDVAVTLVNK 196
D L + PL +A S +L + + NI+D G + L +A+ +A L++
Sbjct: 97 CDRLNRTPLMKAVHSQEEACAIVLLECGANPNIEDIYGNTALHYAVYNKGTSLAERLLS- 155
Query: 197 YHA 199
+HA
Sbjct: 156 HHA 158
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.136 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,560,179
Number of Sequences: 60738
Number of extensions: 628253
Number of successful extensions: 4574
Number of sequences better than 1.0e-05: 233
Number of HSP's better than 0.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 144
Number of HSP's that attempted gapping in prelim test: 2297
Number of HSP's gapped (non-prelim): 1180
length of query: 230
length of database: 30,389,216
effective HSP length: 103
effective length of query: 127
effective length of database: 24,133,202
effective search space: 3064916654
effective search space used: 3064916654
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)