ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV4163 good PT KOG2301 Inorganic ion transport and metabolism Voltage-gated Ca2+ channels, alpha1 subunits
r_klactV4163 good PT KOG2301 Signal transduction mechanisms Voltage-gated Ca2+ channels, alpha1 subunits
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV4163 1438476 1432570 -1969
(1969 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGR217w [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 1770 0.0
SPAC6F6.01 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 699 0.0
7292976 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 206 3e-52
Hs4557401 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 199 5e-50
Hs10337597 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 174 2e-42
CE23561 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 172 6e-42
CE29574 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 170 2e-41
7292723 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 161 1e-38
Hs4506813 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 159 3e-38
7298274 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 159 6e-38
Hs4506809 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 158 9e-38
Hs19923381 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 156 4e-37
Hs20536765 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 155 8e-37
Hs19923117 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 154 1e-36
Hs21914836 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 153 3e-36
Hs7657544 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 151 1e-35
7293235 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 150 2e-35
CE28820 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 150 3e-35
Hs5730033 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 147 2e-34
Hs4502523 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 145 8e-34
Hs4502527 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 142 7e-33
Hs4506807 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 140 2e-32
CE29459 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 140 2e-32
Hs4885103 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 138 8e-32
Hs4502529 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 132 6e-30
Hs13386500 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 130 2e-29
Hs13386498 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 130 2e-29
Hs7657542 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 129 4e-29
Hs4506811 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 120 2e-26
Hs10864077 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-f... 108 7e-23
Hs20070163 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-f... 107 2e-22
Hs18581612 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 105 6e-22
HsM10863883 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-... 104 2e-21
Hs21361077 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-f... 104 2e-21
CE29237 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-form... 94 2e-18
7290679 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-form... 86 5e-16
CE29575 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 75 8e-13
Hs22051246 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 61 2e-08
Hs16876443 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits 52 1e-05
>YGR217w [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2039
Score = 1770 bits (4584), Expect = 0.0
Identities = 925/1920 (48%), Positives = 1256/1920 (65%), Gaps = 81/1920 (4%)
Query: 73 RSFNQDPSTDSLLNANSISG------GSNMLS-ITDDDLQDFKHLQDDVKNILGGDTSQW 125
RSF+ + S +NS S + +LS I DD+ DF+ LQ K+ + + W
Sbjct: 145 RSFSSYSRSSSRRVSNSPSSTDRPPRSAKVLSLIAADDMDDFEDLQKGFKSAIDEEGLTW 204
Query: 126 LRKPTSDGHXXXXXXXXXXXXXXIHETAPVARDHSSDLFTD--DYELQSIPIGTDTPSVN 183
L + S+ ++ PV SD+ D + E +SIP TP+V
Sbjct: 205 LPQLKSE------------------KSRPV-----SDVGEDRGEGEQESIP-DVHTPNVG 240
Query: 184 AFGYHSSYQTS-----TGSIHSNHTRNHDDVGSAPTDTYDNTINDEEDDDPGID------ 232
A S + GS+ + ++ P+ + + ++ +++D +
Sbjct: 241 ASATPGSIHLTPEPAQNGSVSEGLEGSINNSRKKPSPKFFHHLSPQKEDKDQTEVIEYAE 300
Query: 233 -----RTIERHLQ-----LYGKSLGFISPDNRWRLKCASILLKTWYKAFSMLVLTLYTIF 282
T++R L+ LYG SLG SP N R+K A LL Y +LT Y I
Sbjct: 301 DILDFETLQRKLESRPFVLYGHSLGVFSPTNPLRIKIARFLLHRRYSLLYNTLLTFYAIL 360
Query: 283 LAHSVFFGSTASGEKDFSAPSSVFSYVATLIFNSFFTFELIAKVIAFGFWNDSDLMNAIG 342
LA + FS + F + I ++ FT IAK+IAFGFW+DS++ A G
Sbjct: 361 LAIRTYNPHNVVFLYRFSNWTDYFIF----ILSACFTGNDIAKIIAFGFWDDSEMFKAYG 416
Query: 343 KNYVSFWDVTGIRKFYRFLETHYSSKFIHSIIPIRALFQETIDEKKSAALKSSVTVA-DF 401
+ Y S +GI K Y +L Y K I IIP R + + + ++L +S+T
Sbjct: 417 REYKSILQRSGIMKLYIYLREKYGRKLIDFIIPFRIISPGEETKYQRSSLSTSLTKPYGA 476
Query: 402 RNVKSPVDIPRAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKL 461
+ + P PRAF RSSW R++L+S++S WL LSI YD G+R+F+ L RIL+L
Sbjct: 477 KENQRPFGTPRAFARSSWNRIDLVSSVSFWLGMFLSIKSYDTKTGIRIFKPLAILRILRL 536
Query: 462 VDLDSGLVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPS 521
V++D+G+ SILR LKYGIP+L+NV ML+YFW+FFGILGVQ F+GS +RQCVWFNP DP+
Sbjct: 537 VNVDTGMPSILRGLKYGIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNPEDPT 596
Query: 522 DYYQYDMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFD 581
D YQYDMQFCGGYL+ T Y++ D SEG ++KGFLCP SKC+SNANPYNGRISFD
Sbjct: 597 DTYQYDMQFCGGYLDPVTKRKQNYIYEDGSEGSVSKGFLCPQYSKCVSNANPYNGRISFD 656
Query: 582 NIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSF 641
NIVNSMELVFVIMSANTFTDLMY+TMD+D MAACLFFIV I LT+W++NLLIAVL SSF
Sbjct: 657 NIVNSMELVFVIMSANTFTDLMYYTMDSDEMAACLFFIVCIFVLTIWLLNLLIAVLVSSF 716
Query: 642 EVVHEKYTIDKF---STQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFF 698
E+ +E+Y KF S + Y+ V K K++ TK P W+++G+ +Y +E+ F
Sbjct: 717 EIANEEYKKKKFIYGSRKTGYVARIVTGYWKYFKLKANQTKFPNWSQKGLAIYSHVEFIF 776
Query: 699 VLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLAKPN 758
V+ I I AS+K +S + ++ +S +L +E++ RL+LY WKFL KP+
Sbjct: 777 VILIICDIGMRASVKVSTSANCNNILLKTDRGISIVLFIESLARLVLYLPNMWKFLTKPS 836
Query: 759 YVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVTRNLWKKVLKNAI 818
YVYDFIISII V+S ++ LG AWL F ISRFYRV+I F++T+ LWK++L N +
Sbjct: 837 YVYDFIISIITLVISCLAVEGVLGHMYAWLSIFHISRFYRVIISFNLTKKLWKQILSNGV 896
Query: 819 VIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTLIKIASTENWT 878
+IWNLS+FYF F FL ++I+ +YF+G + ++M D PFG YSLPN+FL+L I STENWT
Sbjct: 897 MIWNLSSFYFFFTFLVAIIMAVYFEGVIPPEEMADQPFGMYSLPNSFLSLFIIGSTENWT 956
Query: 879 DSLYALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAVIAASFDIEEEDKRLLQIKH 938
D LYALQ+ SP + S F SV I+WF+LSN V+LN+F+A+I+ S +++EE+KR QIKH
Sbjct: 957 DILYALQKHSPNISSTFFCSVFFIIWFLLSNSVILNIFIALISESMEVKEEEKRPQQIKH 1016
Query: 939 YLKVTYPERIREFSVVPLLERIRRKFLRKPQIDDSEDFRQFLFRGTAILSIAQNYEGFNM 998
YLK YP++I+E++ L+ RIR+KF + +D+ DF+QFL RGTAI++IAQN
Sbjct: 1017 YLKFVYPQKIQEYTHASLVARIRKKFFGGHRNEDTRDFKQFLMRGTAIMNIAQNMGELAD 1076
Query: 999 DLSEDKDHQFADRNVKSSFWNRILWRLKALNFYKTNPFFKDPKVVFVQSDDTTPSNRKYT 1058
+ E + + + LK L + NPF+K+ VVF +++D + R Y
Sbjct: 1077 EFKEPPSENLFKKGLSKLTIG--VPSLKRLRMFANNPFYKNSDVVFTETNDI--NGRTYI 1132
Query: 1059 LKLNDWEEEKLRFLKQHPNFNNTYFIFPPNHALRRFCQRLVPPSYGKRTNNRVFFDDTTN 1118
L+LN++E+EKL +LK++P FN +Y+ F P H RRFCQRLVPPS GKRT+ FF+D+T+
Sbjct: 1133 LELNEYEDEKLDYLKKYPLFNYSYYFFSPQHRFRRFCQRLVPPSTGKRTDGSRFFEDSTD 1192
Query: 1119 KVGQKRFFYNIEKDIFVFVTFVATLLMVIYSCYVTPLYRMNHNK-KWNWTTYFEPVFVPL 1177
++ +F++IE+D+FVF+ +AT+L+++ SCYVTPLYRM+H WNW++ + F+
Sbjct: 1193 LYNKRSYFHHIERDVFVFIFALATILLIVCSCYVTPLYRMHHKMGTWNWSSALDCAFIGA 1252
Query: 1178 FTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELARIIKAVSA 1237
F+IEF+VKT+ADGFIY+PNAY NPWN ID VLI++WI+ A+L NG L+RI K ++A
Sbjct: 1253 FSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCVLISMWINLIAYLKNNGNLSRIFKGLTA 1312
Query: 1238 LRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRLGVCNDG 1297
LRALR LTIS+ AR TF VMFDGL IF A ++ S+LFP+TVWGL++F+GRLG CNDG
Sbjct: 1313 LRALRCLTISNTARQTFNLVMFDGLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGTCNDG 1372
Query: 1298 DLSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMYEIVSLEGWTDLLQNMM 1357
L +CYNE++N VF WDI+ PR Y P LHL+SF+SAF S+Y+I+SLEGW DLL+NMM
Sbjct: 1373 SLGRADCYNEYSNSVFQWDIMSPRVYQQPYLHLDSFASAFSSLYQIISLEGWVDLLENMM 1432
Query: 1358 SSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNARMKGTAYLTLAEKSW 1417
+S+G+GTPA + S + +FL+LFNFLSMVFILN+FVSFIV N AR G+AY T+ EK+W
Sbjct: 1433 NSSGIGTPATVMGSAGNALFLVLFNFLSMVFILNLFVSFIVNNQARTTGSAYFTIEEKAW 1492
Query: 1418 LEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFSVLMQFMLYLHILTLLMSKD 1477
LE ++LLSQ P +PN+ +++ VR+ Y AVEK+NFY++ +Q +LYLHI+ LL
Sbjct: 1493 LESQKLLSQAKPKAIPNLIELSRVRQFFYQLAVEKKNFYYASFLQVVLYLHIIMLLSRSY 1552
Query: 1478 QPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYE 1537
P G L Q + FM +TS LIQE +H+ G+ RLY R++WN R +++ AF N
Sbjct: 1553 NP-GNLIGYQGVYFMFSTSVFLIQEALHMCGEGPRLYFRQKWNSIRLSIIIIAFIMNAVA 1611
Query: 1538 LIVDHVVVGISNARDVFQLGIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVY 1597
V N + F L IFL +IPQNDTL EL+ TA ASLP I SL YTW +LFLVY
Sbjct: 1612 FHVPASHYWFHNIKGFFLLVIFLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVY 1671
Query: 1598 AIALNQVFGVTKLGPNTTGNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEA 1657
AIALNQ+FG+T+LG NTT NIN RTV KS+I+LFRCSFGEGWNYIM DLT+ EP+C S+
Sbjct: 1672 AIALNQIFGLTRLGSNTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSEPYCSSDD 1731
Query: 1658 DGSYTDCGSKAFAYALLMSWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVR 1717
+ +YTDCGS+ +AY LLMSWNIISMYIFVNMFVSLI+ FSYVY R S ++ E++
Sbjct: 1732 NSTYTDCGSETYAYLLLMSWNIISMYIFVNMFVSLIIGNFSYVY-RSGGSRSGINRSEIK 1790
Query: 1718 KFKVAWREIDPDGVGQFDVAYLPKFMHSFDGPLSFKIWEGRLTVKSLVSKYMKVNPNDPY 1777
K+ AW + D DG G+ +++YLP+ MHSFDGPLSFKIWEGRLT+KSLV YM+VNP+DPY
Sbjct: 1791 KYIEAWSKFDTDGTGELELSYLPRIMHSFDGPLSFKIWEGRLTIKSLVENYMEVNPDDPY 1850
Query: 1778 DVEIDHFGLSKELSSIDYQKVNARRLDYNRFVHEIQLGNKRYNAVQFNQLMETVPLYTTY 1837
DV+ID GL+KEL++ID K+ R+L Y RFV I N ++F+ L+ +PLYT Y
Sbjct: 1851 DVKIDLIGLNKELNTIDKAKIIQRKLQYRRFVQSIHYTNAYNGCIRFSDLLLQIPLYTAY 1910
Query: 1838 NKTECLGIDDYVKNLYDMNKVDKLIRNERNYDTMLMVVARWKFLLNRRGKIQLPKIMV-- 1895
+ ECLGID YV +LY + KVDK + N+RN+D + MVV RWKF + I+ P+ V
Sbjct: 1911 SARECLGIDQYVHHLYILGKVDKYLENQRNFDVLEMVVTRWKFHCRMKRTIE-PEWDVKD 1969
Query: 1896 -PISSYPNGSTEDFE-----LE---FKSPVLNTQESEFMWSPGRRNNHWFEEDESSSKEN 1946
+SS+ + + E LE +P ++ + FMWSP + E E N
Sbjct: 1970 PTVSSHISNINVNLEPAPGILEREPIATPRMDYGVNNFMWSPRMNQDSTMEPPEEPIDNN 2029
>SPAC6F6.01 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1854
Score = 699 bits (1805), Expect = 0.0
Identities = 469/1535 (30%), Positives = 756/1535 (48%), Gaps = 154/1535 (10%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSIL 472
++ R SW R++ ++ ++ W+ S+ RLF + R+ +L+++ +IL
Sbjct: 264 SYLRHSWNRVDFVAIVALWI----SVIGKKQQGIFRLFSMIACLRLTRLLNITRKTETIL 319
Query: 473 RALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCG 532
++LK L+ V +F V ILGVQ FK SL RQCVW D D Y QFCG
Sbjct: 320 KSLKESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCVWLG--DYGDQYLPTGQFCG 377
Query: 533 GYLNAETLEPMKYVFADNSEGPL---AKGFLCPANSKCISNANPYNGRISFDNIVNSMEL 589
G+ +K + D + P +GF+C S C NPY+ +SFDN NS+EL
Sbjct: 378 GHWE----NGIKRAYLDKNGFPSNVNPRGFICAEKSVCRVVENPYSNTVSFDNFFNSLEL 433
Query: 590 VFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSF-EVVHEKY 648
+FVIMS+N FTD+MY MD + +CL FI+S LT+W+++L+IAV+ SSF ++ H
Sbjct: 434 IFVIMSSNGFTDIMYDIMDAEYFVSCLLFIISAYFLTLWLMSLVIAVVTSSFIDLQHSGK 493
Query: 649 TIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWF-FVLAIFTSIC 707
+ + D +L+ N +L Y W F++A F ++C
Sbjct: 494 NQKEQKSVDKHLIRNKLCEKYLF-------------------YSNFIWISFIVAQFVTLC 534
Query: 708 ALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLAKPNYVYDFIISI 767
++ S+ A V +L E ILR Y F + + D ++++
Sbjct: 535 TQTYDQTSST---ANRYLIFYACVDFLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAV 591
Query: 768 ICAVLSFNSLR---ISLGQTSAWLLFFPISRFYRVVILFSVTRNLWKKVLKNAIVIWNLS 824
+ V S+R ++ G WL F I+R YR ++L TR + K + N + NL
Sbjct: 592 LNLVTLLPSIRKNPVAFG----WLSIFAIARIYRCILLIPYTRKIAKLLFSNFKQLLNLM 647
Query: 825 AFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSLYAL 884
F + +F+ASL + F + D +D F + +FL + +I ++ENWTD ++A+
Sbjct: 648 LFLVIVLFIASLCAVRLFQDLPNDGDSDDDAISFATTYESFLYMYQILTSENWTDVMFAI 707
Query: 885 QRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAVIAASFDIEEEDKRLLQIKHYLKV-- 942
Q L + LWF+ SN VVL++F+AVI +F E D ++ Q+K YL
Sbjct: 708 QARLAHLHLSWIPGAFFTLWFLFSNNVVLSMFIAVIQVNFAPSESDLKMEQLKMYLARLL 767
Query: 943 -TYPERIREFSVVPLLER---------------------IRRKFLR----------KPQI 970
Y ++ L++R I + FLR KP +
Sbjct: 768 RNYNPFQASLTLNALIKRNGSRKGKTVDESHYEWLYEDNIIKGFLRVTNIPPKEPLKPSL 827
Query: 971 DDSEDFRQFLFRGTAILSIAQNYEGFNMDLSEDKDHQFADRNVKSSFWNRILWRLKALNF 1030
D S + ++ ++ ++ N++ F M +D F+ K R W K +N
Sbjct: 828 DTSPELSKY-----SLAKLSNNFKRFVM-----RDDPFSQAYFKRVIGIR--WE-KDMNL 874
Query: 1031 YKTNPFFKDPKVVFVQSDDTTPSNRKYTLKLNDWEEEKLRFLKQHPNFNNTYFIFPPNHA 1090
KT FV+ T FLK HP +N+ +++ P++
Sbjct: 875 -KTAAKDMQAAKAFVRIKQT-------------------EFLKNHPKYNDVFWVIKPSNR 914
Query: 1091 LRRFCQRLVPPSYGKRTNNRVFFDDTTNKVGQKRFFYNIEKDIFVFVTFVATLLMVIYSC 1150
+RRFCQRLV P +R V ++ Y + I VF+ + L VI C
Sbjct: 915 IRRFCQRLVMPGVNERYGG----------VEPYQWVYRV---IQVFI-YACILTAVIIEC 960
Query: 1151 YVTPLYRMNH---NKKWNWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRID 1207
TP+Y +H +K+ W + E F +FTIE +K IADGF TPNAY + WN ID
Sbjct: 961 IATPIYERDHLLNDKQHAWFVWTEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCID 1020
Query: 1208 LVVLIALWIDFFAWLLGNGELARIIKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFG 1267
VL+ LWI+ +A L + L+R +A ALR LR + ++ ++ F + G IF
Sbjct: 1021 FFVLVTLWINLYAVLTSHALLSRAFRAFKALRVLRLINLTQTSQRMFHDALISGFFKIFS 1080
Query: 1268 ACAVAFSILFPYTVWGLNVFRGRLGVCNDGD-LSYGECYNEFTNQVFHWDILMPRTYADP 1326
A V+ ++L P+ +W NVF G L CND + LS +C E+ + +W++ PR +++P
Sbjct: 1081 AAVVSATLLIPFALWAKNVFGGLLYSCNDDNVLSASQCVLEYASTPNNWEVWAPRVWSNP 1140
Query: 1327 ILH-LNSFSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLS 1385
+ + F A +++EI S+EGW D+++++M TG + AS + +F +LFN +S
Sbjct: 1141 PDYDFDRFPHALLALFEIASIEGWVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVS 1200
Query: 1386 MVFILNIFVSFIVGNNARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRIC 1445
M++IL +F++ I+ N A G+A+ T +++WLE++R + + P P + + +R +C
Sbjct: 1201 MIYILTLFIAIIISNYAERTGSAFFTAEQRAWLELRRKIKSMRPSKRPAIRPLG-LRGLC 1259
Query: 1446 YLWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTN-QNIQFMVTTSFLLIQEVM 1504
Y +AV+K + LY+ L L++ P T +N F++ + I +
Sbjct: 1260 YDFAVQKHGIWRRTFTG--LYIVHLLFLLTIFYPCPIAYTYVRNSIFLILSICYTINICV 1317
Query: 1505 HIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLLV-- 1562
+YG S + WN+F VV + + NI L + + + Q + +LV
Sbjct: 1318 KVYGLSFYYFFHSFWNMFDVVVTLGSLTCNIAILAKFE-----NRSLTLLQTTLLVLVTV 1372
Query: 1563 --IPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINC 1620
IP+ D ++L T ASLPSIFSL+ TW +L++ +AIA NQ+FG+TKLG N N N
Sbjct: 1373 HLIPKFDNFDQLSKTVVASLPSIFSLIATWIVLYITFAIAFNQIFGLTKLGLNGGPNKNF 1432
Query: 1621 RTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNII 1680
R++ +L+LLF +FGEGWN +M+D TI P C + D +DCG+K +AY L ++WNII
Sbjct: 1433 RSIRNALVLLFTMTFGEGWNDVMHDYTISYPNCVNGDDFYNSDCGNKPWAYGLFIAWNII 1492
Query: 1681 SMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLP 1740
SMYIFVNMF++++ + FSY+ H + + + + + R+FK +W DP G
Sbjct: 1493 SMYIFVNMFITVVFDNFSYI-HTKSSSFTNLQRNDFRQFKDSWAPFDPMVTGYIPKRNAV 1551
Query: 1741 KFMHSFDGPLSFKIWEGRLTVKSLVSKY--------MKVNPNDPYDVEIDHFGLSKELSS 1792
KF+ S G F+I+ T++S++SK + + N EI+ L + + +
Sbjct: 1552 KFVLSLRGVYDFRIYRDEHTLRSIISKVQSKTGQQSVPMLENPLMGSEINLEALDQIIDT 1611
Query: 1793 IDYQKVNARRLDYNRFVHEIQLGNKRYNAVQFNQLMETVPLYTTYNKTECLGIDDYVKNL 1852
ID V RR N EI N + F+ ++ V L+ + E I DY++
Sbjct: 1612 IDVNVVKERRNVLNSLCTEIM--TLPGNVISFSNILMLVVLHKIVDHREAFPISDYIRRA 1669
Query: 1853 YDMNKVDKLIRNERNYDTMLMVVARWKFLLNRRGK 1887
Y +++++K IR E+ + + R FL + K
Sbjct: 1670 YVLSELEKSIRMEKLLGLVETSIIRKTFLQHMEEK 1704
Score = 67.0 bits (162), Expect = 3e-10
Identities = 124/628 (19%), Positives = 244/628 (38%), Gaps = 128/628 (20%)
Query: 1132 DIFVFVTFV--ATLLMVIYSCYVTPLYRMNHNKKWNWTTYFEPVFVPLFTIEFLVKTIAD 1189
+IF+FV V A LLM+ + + K Y V L+T+E L+K
Sbjct: 188 NIFIFVVIVLHAVLLMIRSD---------DPHDKSQTIDYLIIVIGILYTLEMLLKIYLF 238
Query: 1190 GFIY----------------TPN--AYCLNPWNRIDLVVLIALWIDFFAWLLGNGE--LA 1229
GF+Y TP +Y + WNR+D V ++ALWI ++G + +
Sbjct: 239 GFLYDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFVAIVALWIS----VIGKKQQGIF 294
Query: 1230 RIIKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILF--PYTVWGLNVF 1287
R+ ++ LR R L I+ K + + V+F+ F + G+ F
Sbjct: 295 RLFSMIACLRLTRLLNITRKTETILKSLKESSTPLV---QVVSFNAFFGVMIAILGVQFF 351
Query: 1288 RGRLGVCNDGDLSYGECY---NEFTNQVFHWDILMPRTYAD------------------- 1325
+ L YG+ Y +F HW+ + R Y D
Sbjct: 352 KASLNRQCVWLGDYGDQYLPTGQFCGG--HWENGIKRAYLDKNGFPSNVNPRGFICAEKS 409
Query: 1326 -------PILHLNSFSSAFRSM---YEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSG 1375
P + SF + F S+ + I+S G+TD++ ++M AE F S
Sbjct: 410 VCRVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMD-------AEYFVSCL-- 460
Query: 1376 IFLILFNFLSMVFILNIFVSFIVGNNARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNV 1435
+F+I FL++ +++++ ++ + + ++ + +KS ++ + +++C
Sbjct: 461 LFIISAYFLTL-WLMSLVIAVVTSSFIDLQHSGKNQKEQKS-VDKHLIRNKLC------- 511
Query: 1436 FKMNAVRRICYLWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPT--NQNIQFMV 1493
EK FY + + + +TL Q Y + + N+ + F
Sbjct: 512 ---------------EKYLFYSNFIWISFIVAQFVTLC---TQTYDQTSSTANRYLIFYA 553
Query: 1494 TTSFLLIQEVM---HIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNA 1550
FLL EV+ Y RL+ R+ N+ V+ + T + + + V G +
Sbjct: 554 CVDFLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTLLPSIRKNPVAFGWLSI 613
Query: 1551 RDVFQLGIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKL 1610
+ ++ +L+IP + +L+ + L ++ +++ +LF+ A+ +
Sbjct: 614 FAIARIYRCILLIPYTRKIAKLLFSNFKQLLNL--MLFLVIVLFIASLCAVRLFQDLPND 671
Query: 1611 GPNTTGNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFA 1670
G + I+ T +S + +++ E W +M I+ +
Sbjct: 672 GDSDDDAISFATTYESFLYMYQILTSENWTDVM--FAIQARLAHLHLSW---------IP 720
Query: 1671 YALLMSWNIISMYIFVNMFVSLIVEKFS 1698
A W + S + ++MF+++I F+
Sbjct: 721 GAFFTLWFLFSNNVVLSMFIAVIQVNFA 748
>7292976 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2230
Score = 206 bits (524), Expect = 3e-52
Identities = 178/736 (24%), Positives = 322/736 (43%), Gaps = 66/736 (8%)
Query: 1066 EEKLRFLKQHPNFNNTYFIFPPNHALRRFCQRLVPPSYGKRTNNRVFFDDTTNKVGQKRF 1125
EE LR + HP F+ F+ P R+ CQ++V Y R D T K +++
Sbjct: 1160 EEDLR--ENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLK-----DPLTGK--ERKV 1210
Query: 1126 FYNIEKDIFVFVTFV------ATLLMVIYSCYVTPLYRMNHNKKWNWTTYFEPVFVPLFT 1179
Y + VT++ AT L I + TP YR+ + Y FV +
Sbjct: 1211 QYKSLHNFLGLVTYLDWVMIFATTLSCISMMFETPNYRVMDHPTLQIAEYG---FVIFMS 1267
Query: 1180 IEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWL---LGNGELARIIKAVS 1236
+E +K +ADG +TP AY + +D+ + + F W+ + A+++ +
Sbjct: 1268 LELALKILADGLFFTPKAYIKDVAAALDVFIYVVS-TSFLCWMPLNIPTNSAAQLLMILR 1326
Query: 1237 ALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRLGVCND 1296
+R LR T+ R ++ G I + ++F + +G+ ++ GRL CND
Sbjct: 1327 CVRPLRIFTLVPHMRKVVYELC-RGFKEILLVSTLLILLMFIFASYGVQLYGGRLARCND 1385
Query: 1297 GDLSYGE-CYNEFTNQVF-------------HWDILMPRTYADPI-LHLNSFSSAFRSMY 1341
+S E C F +VF + +L+PR +A+P + ++ A +++
Sbjct: 1386 PTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLF 1445
Query: 1342 EIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNN 1401
E++S +GW D+ ++ + G P +++ ++ FL + L +FV ++ N
Sbjct: 1446 EVLSFKGWLDVRDVLIKAVG----------PVHAVYIHIYIFLGCMIGLTLFVGVVIANY 1495
Query: 1402 ARMKGTAYLTLAEKSWLEVKRLLSQVCP---DPMPNVFKMNAVRRICYLWAVEKRNFYFS 1458
+ KGTA LT+ ++ W ++K+ L P P P+ K+ A + KR
Sbjct: 1496 SENKGTALLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVV 1555
Query: 1459 VLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARKR 1518
VL+ ML L++ K G++ T + + +F+ + EV+ K++ R
Sbjct: 1556 VLINSML----LSITWIK----GEVHTERLVIVSAVLTFVFVVEVVM---KNIAFTPRGY 1604
Query: 1519 WNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGI--FLLVIPQNDTLNELMNTA 1576
W R + + +I+ ++ + F + I F + ++ TL LM T
Sbjct: 1605 WQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTV 1664
Query: 1577 TASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKSLILLFRCSFG 1636
S+ F +++ F+L YA+A +FG K G N + + +LFR G
Sbjct: 1665 GVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGIGRRANFGSPVTGVAMLFRIVTG 1724
Query: 1637 EGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMFVSLIVEK 1696
E WN IM+D ++ P+C + TDCG+ + ++ +I YI +N+ V++I+E
Sbjct: 1725 EDWNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMEN 1784
Query: 1697 FSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSFDGPLSFKIWE 1756
FS Y EE+ + S ++R F+ W +D G V + + G L +
Sbjct: 1785 FSLFYSNEED--ALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILRLLKGRLECDPQK 1842
Query: 1757 GRLTVKSLVSKYMKVN 1772
RL K + + K++
Sbjct: 1843 DRLLFKYMCYELDKLH 1858
Score = 89.7 bits (221), Expect = 4e-17
Identities = 126/559 (22%), Positives = 232/559 (40%), Gaps = 67/559 (11%)
Query: 447 LRLFRSLMAFRILKL-VDLDSGLVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFK 505
+R R L+ R L++ + I + K ++ NV L+F +G+LGVQ F
Sbjct: 462 MRAPRPLIMIRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF- 520
Query: 506 GSLKRQCVWFNPNDPSDYYQYDMQFCGGYLNAETLE-PMKYVFADNSEG-PLAKGFLCPA 563
G LK CV N +YD+ + L +L P + D G + G +C
Sbjct: 521 GELKNHCVMNNT-------EYDL-YKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMK 572
Query: 564 NSKCISNANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSIL 623
S +NG F++I S+ V+ S + +MY +D+ F+ +++
Sbjct: 573 MDFLSSYVIGFNG---FEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMI 629
Query: 624 CLTVWMV-NLLIAVLYSSFEVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDT----- 677
W+V N+ IAV+ +F + ++ + + + K A I S +DT
Sbjct: 630 FFLAWLVKNVFIAVITETFNEIRVQFQ-QMWGARGHIQ----KTAASQILSGNDTGWRLV 684
Query: 678 ----TKSPAWAERGIRLYEKLEWF--FVLAIFTSICALASMKSHSSDQSAQDIFS----- 726
K A + +F V+++ + + + + D +D+F
Sbjct: 685 TIDDNKHGGLAPETCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGRPRDVFYERYYY 744
Query: 727 VNQIVSCILVVETILRLILYCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSA 786
+ + +C+L +ET+ ++ YC L Y I + + +L I +
Sbjct: 745 IELVFTCLLDLETLFKI--YC------LGWRGYYKHSIHKFELLLAAGTTLHIVPMFYPS 796
Query: 787 WLLFFPISRFYRVVILFSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTL 846
L +F + R R++ + K+ + +L F + ++S I + F
Sbjct: 797 GLTYFQVLRVVRLIKASPMLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLFCFLC 856
Query: 847 DADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSL-YALQRDSPTLFSALFGSVLLILWF 905
D E S P AF+++ +I + E W + + + R S TL + +V IL+
Sbjct: 857 DFTKFE-------SFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLV--AVYFILYH 907
Query: 906 ILSNFVVLNVFVAVIAASFDIEEEDKRLLQIKH-----YLKVTYPERIREFSVVP----- 955
+ +VL++FVAVI + +++E+ K+L Q+K +K T P R+R F P
Sbjct: 908 LFVTLIVLSLFVAVILDNLELDEDIKKLKQLKFREQSAEIKETLPFRLRIFEKFPDSPQM 967
Query: 956 -LLERIRRKFLRKPQIDDS 973
+L RI F+ P++ +S
Sbjct: 968 TILHRIPNDFM-LPKVRES 985
Score = 56.6 bits (135), Expect = 4e-07
Identities = 117/576 (20%), Positives = 228/576 (39%), Gaps = 66/576 (11%)
Query: 411 PRAFTRSSWGRLELL-----STISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLD 465
P+A+ + L++ ++ W+ + N +L L R L++ L
Sbjct: 1283 PKAYIKDVAAALDVFIYVVSTSFLCWMPLNIPTNS-----AAQLLMILRCVRPLRIFTLV 1337
Query: 466 SGLVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQ 525
+ ++ L G E+L V +L+ F GVQ + G L R C NDP+ +
Sbjct: 1338 PHMRKVVYELCRGFKEILLVSTLLILLMFIFASYGVQLYGGRLAR-C-----NDPTISRR 1391
Query: 526 YDMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVN 585
D C G M+ VF + PA ANP R +FDNI +
Sbjct: 1392 ED---CVGVF-------MRRVFVTKMKLTPGPDESYPAMLVPRVWANP--RRFNFDNIGD 1439
Query: 586 SMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSFEVVH 645
+M +F ++S + D+ + ++ + I + + L + V+ +++
Sbjct: 1440 AMLTLFEVLSFKGWLDVRDVLIKAVGPVHAVYIHIYIFLGCMIGLTLFVGVVIANYSENK 1499
Query: 646 --EKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFFVLAIF 703
T+D+ D + + HL + D K A+ + + + + V+A+
Sbjct: 1500 GTALLTVDQRRWCDLKKRLKIAQPLHL-PPRPDGRKIRAFT---YDITQHIIFKRVIAVV 1555
Query: 704 TSI-CALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLAKPNYVYD 762
I L S+ + + + V+ +++ + VVE +++ I + TP + YD
Sbjct: 1556 VLINSMLLSITWIKGEVHTERLVIVSAVLTFVFVVEVVMKNIAF--TPRGYWQSRRNRYD 1613
Query: 763 FIIS------IICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVTRNLWKKVLKN 816
+++ II + N L G L FF I+ + + + +T + V K+
Sbjct: 1614 LLVTVAGVIWIILQTILRNDLSYFFGFMVVILRFFTITGKHTTLKMLMLTVGV--SVCKS 1671
Query: 817 AIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTLIKIASTEN 876
+I+ + FL VF +L + F GT+ + F S L +I + E+
Sbjct: 1672 FFIIFGM----FLLVFFYALAGTILF-GTVKYGEGIGRRANFGSPVTGVAMLFRIVTGED 1726
Query: 877 WTDSLYALQRDSP--TLFSALFGS---------VLLILWFILSNFVVLNVFVAVIAASFD 925
W ++ P TL + + + + ++++ ++VLN+ VA+I +F
Sbjct: 1727 WNKIMHDCMVQPPYCTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFS 1786
Query: 926 I---EEEDKRL--LQIKHYLKVTYPERIREFSVVPL 956
+ EED L I+++ I + V+P+
Sbjct: 1787 LFYSNEEDALLSYADIRNFQNTWNIVDIHQRGVIPV 1822
>Hs4557401 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1873
Score = 199 bits (505), Expect = 5e-50
Identities = 286/1443 (19%), Positives = 558/1443 (37%), Gaps = 269/1443 (18%)
Query: 451 RSLMAFRILKLVDLDSGLVS---ILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGS 507
++L AFR+L+ + L SG+ S +L ++ + L ++ ++L+ + + I+G++ FKG
Sbjct: 162 KALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGK 221
Query: 508 LKRQCVWFNPNDPSDYYQYDMQFCGGYLNAETLEPMKYVFADNSEGPLAK---GFLCPAN 564
+ + C + + + E EP P A+ G C N
Sbjct: 222 MHKTCYFIGTDIVA--------------TVENEEP----------SPCARTGSGRRCTIN 257
Query: 565 -SKCISNA-NPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDT-DNMAACLFFIVS 621
S+C P +G FDN SM V+ ++ +TD++Y+ D N ++F+
Sbjct: 258 GSECRGGCPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTL 317
Query: 622 ILCLTVWMVNLLIAVLYS-------------SFEVVHEKYTIDK---------------- 652
IL + +++NL++ VL +F+ + EK +D+
Sbjct: 318 ILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMD 377
Query: 653 ---------------FSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWF 697
T+ Y + + ++ I+ + W I + W
Sbjct: 378 VEDFREGKLSLDEGGSDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWL 437
Query: 698 FVLAIFTSICALASMKSHSSDQ---SAQDIFSVNQIVSCILVVETILRLILYCKTPWKFL 754
+L + + ++AS + H+ QDI N+++ + E ++++ L
Sbjct: 438 VILIVALNTLSIAS-EHHNQPHWLTRLQDI--ANRVLLSLFTTEMLMKMY--------GL 486
Query: 755 AKPNYVYDFIISIICAVLSFNSLRISLGQTSAWL-LFFPISRFYRVVILFSVTR------ 807
Y C V+ L I L ++ A L + R R++ +F +T+
Sbjct: 487 GLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLS 546
Query: 808 NLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLT 867
NL +L + I +L FLF+ + L+ + F G D +D E F + P A ++
Sbjct: 547 NLVASLLNSIRSIASLLLLLFLFIVIFRLLGMQLFGGRYDFEDTEVRRSNFDNFPQALIS 606
Query: 868 LIKIASTENWTDSLY-ALQRDSPTLFSALFGSVLLILWFILSNF----VVLNVFVAVIAA 922
+ ++ + E+WT +Y + S + + + I+ F+ N+ V L + V +A
Sbjct: 607 VFQVLTGEDWTSMMYNGIMASSGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAE 666
Query: 923 SFDIEEEDKRLLQIKHYLKVT--YPERIREFSVVPLLERIRRKFLRKPQIDDSEDFRQFL 980
+ + K + K K++ P++ E + +K +KP
Sbjct: 667 AESLTSAQKAKAEEKKRRKMSKGLPDKSEEEK-----STMAKKLEQKP------------ 709
Query: 981 FRGTAILSIAQ-NYEGFNMDLSEDKDHQFADRNVKSSFWNRILWRLKALNFYKTNPFFKD 1039
+G I + A+ + F +++E KD P+
Sbjct: 710 -KGEGIPTTAKLKIDEFESNVNEVKD-----------------------------PY--- 736
Query: 1040 PKVVFVQSDDTTPSNRKYTLKLNDWEEEKLRFLKQHPNFNNTYFIFPPNHALRRFCQRLV 1099
P F D+ + + E +L+ +++FIF P + +R C R+V
Sbjct: 737 PSADFPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIV 796
Query: 1100 PPSYGKRTNNRVFFDDTTNKVGQKRFFYNIEKDIFVFVTFVATLLMVIYSCYVTPLYRMN 1159
++ F F+ +++ +
Sbjct: 797 NATW--------------------------------FTNFILLFILLSSAALAAEDPIRA 824
Query: 1160 HNKKWNWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFF 1219
+ + +F+ F +FT+E ++K G ++C N +N +DL+V+ I
Sbjct: 825 DSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMG 884
Query: 1220 AWLLGNGELARIIKAVSALRALRFLTISSMAR--MTFKQVMFDGLTYIFGACAVAFSILF 1277
++K + LR LR L + A+ + MF ++ I V + F
Sbjct: 885 L----ESSAISVVKILRVLRVLRPLRAINRAKGLKHVARCMFVAISTIGNIVLVTTLLQF 940
Query: 1278 PYTVWGLNVFRGRLGVCND-GDLSYGEC---YNEFTNQVFHWDILMPRTYADPILHLNSF 1333
+ G+ +F+G+ C D ++ EC Y + + L R + H ++
Sbjct: 941 MFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNV 1000
Query: 1334 SSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIF 1393
SA S++ + + EGW LL + S IF I++ L F++NIF
Sbjct: 1001 LSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIF 1060
Query: 1394 VSFIVGNNARMKGTAYLTLAEKSWLEVKRL-LSQVCPDPMPNVFKMNAVRRICYL----- 1447
V F++ +T E+ E K L + + K +R CY+
Sbjct: 1061 VGFVI-----------VTFQEQGETEYKNCELDKNQRQCVQYALKARPLR--CYIPKNPY 1107
Query: 1448 ----WAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLI--- 1500
W + + YF LM ++ L+ + L M Q Y + +I ++ +F +I
Sbjct: 1108 QYQVWYIVTSS-YFEYLMFALIMLNTICLGM---QHYNQSEQMNHISDILNVAFTIIFTL 1163
Query: 1501 QEVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLG--- 1557
+ ++ + R Y WN+F ++V+ +I ++I+ + ++++ ++ LG
Sbjct: 1164 EMILKLMAFKARGYFGNPWNVFDFLIVI----GSIIDVILSEIDTFLASSGGLYCLGGGC 1219
Query: 1558 ----------------------IFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFL 1595
+ ++ + + + L+ T S ++ + +LF
Sbjct: 1220 GNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFF 1279
Query: 1596 VYAIALNQVFGVTKL--GPNTTGNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFC 1653
+YA+ Q+FG L G N N +T ++++LLFRC+ GE W I+ + + C
Sbjct: 1280 IYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGK-LC 1338
Query: 1654 YSEAD---GSYTDCGSKAFAYALLMSWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSP 1710
E+D G CG+ FAY +S+ ++ ++ +N+FV++I++ F Y+ S
Sbjct: 1339 DPESDYAPGEEYTCGTN-FAYYYFISFYMLCAFLVINLFVAVIMDNFDYL----TRDWSI 1393
Query: 1711 ASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSFDGPLSF-KIWEGRLTVKSLVSKYM 1769
+ +FK W E DP+ G+ + + PL F K R+ K LV M
Sbjct: 1394 LGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNM 1453
Query: 1770 KVN 1772
+N
Sbjct: 1454 PLN 1456
Score = 90.5 bits (223), Expect = 2e-17
Identities = 139/618 (22%), Positives = 239/618 (38%), Gaps = 118/618 (19%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSIL 472
+F R+ + L+LL + ++ GL + V LR+ R L R L+ ++ GL +
Sbjct: 862 SFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVL---RPLRAINRAKGLKHVA 918
Query: 473 RALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCG 532
R + I + N+ + F +GVQ FKG R C +D + + C
Sbjct: 919 RCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFR-C--------TDLSKMTEEECR 969
Query: 533 GYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVFV 592
GY YV+ D + + + + FDN++++M +F
Sbjct: 970 GYY---------YVYKDGDPMQIE-----------LRHREWVHSDFHFDNVLSAMMSLFT 1009
Query: 593 IMSANTFTDLMYFTMDT----------DNMAACLFFIVSILCLTVWMVNLLIAVLYSSF- 641
+ + + L+Y +D+ + + +FFI+ I+ + +M+N+ + + +F
Sbjct: 1010 VSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQ 1069
Query: 642 ---EVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFF 698
E ++ +DK Q + L I + + W +E L F
Sbjct: 1070 EQGETEYKNCELDKNQRQCVQYALKARPLRCYI--PKNPYQYQVWYIVTSSYFEYL--MF 1125
Query: 699 VLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLIL-----YCKTPWK- 752
L + +IC L + S+Q +N + I +E IL+L+ Y PW
Sbjct: 1126 ALIMLNTIC-LGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGNPWNV 1184
Query: 753 --FLAKPNYVYDFIISIICAVLSFNSLRISLG--------QTSAWL--LFFPISRFYRVV 800
FL + D I+S I L+ + LG SA + FF + R R++
Sbjct: 1185 FDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLI 1244
Query: 801 ILFSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYF----------------DG 844
L S + ++W + ++A LIV+L+F DG
Sbjct: 1245 KLLSRAEGV-------RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDG 1297
Query: 845 TLDADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSL----YALQRDSPTLFS------- 893
T + F + P A L L + A+ E W + L Y D + ++
Sbjct: 1298 T-----QINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTC 1352
Query: 894 -ALFGSVLLILWFILSNFVVLNVFVAVIAASFDIEEEDKRLLQIKHY--LKVTYPE---- 946
F I +++L F+V+N+FVAVI +FD D +L H K + E
Sbjct: 1353 GTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPE 1412
Query: 947 ---RIREFSVVPLLERIR 961
RI+ VV LL RI+
Sbjct: 1413 AKGRIKHLDVVTLLRRIQ 1430
>Hs10337597 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2005
Score = 174 bits (440), Expect = 2e-42
Identities = 232/1103 (21%), Positives = 468/1103 (42%), Gaps = 113/1103 (10%)
Query: 711 SMKSHSSDQSAQDIFSVNQIV-SCILVVETILRLILYCKTPWKFLAKPNYVYD-FIISII 768
+M+ + + + SV +V + I E L++I P+ + + ++D FI+S
Sbjct: 777 AMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII--AMDPYYYFQEGWNIFDGFIVS-- 832
Query: 769 CAVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVTRNLWKKVLKNAI-VIWNLSAFY 827
LS L ++ + + L F + R +++ + T N+ K++ N++ + NL+
Sbjct: 833 ---LSLMELGLANVEGLSVLRSFRLLRVFKLAKSWP-TLNMLIKIIGNSVGALGNLTLVL 888
Query: 828 FLFVFLASLIVLLYFDGTLD------ADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSL 881
+ VF+ +++ + F + ++D E + + ++FL + ++ E W +++
Sbjct: 889 AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETM 947
Query: 882 Y-ALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAVIAASFDIE-----EEDKRLLQ 935
+ ++ T+ +F V++I N VVLN+F+A++ +SF + ++D +
Sbjct: 948 WDCMEVAGQTMCLTVFMMVMVI-----GNLVVLNLFLALLLSSFSSDNLAATDDDNEMNN 1002
Query: 936 IKHYLKVTYPERIREFSVVPLLERIRRKFLRKPQ-IDDSEDFRQFLFRGTAILSIAQNYE 994
++ + V ++ +F + E I++ F+RK + +D+ + + + +S E
Sbjct: 1003 LQ--IAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIE 1060
Query: 995 GFNMDLSEDKDHQFADRNVKSSFWNRILWRLKALNFYKTNPFFKDPKVVFVQSDDTTPSN 1054
DL+ KD + SS ++ ++F NP + V D N
Sbjct: 1061 -IGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFIN-NPSLTVTVPIAVGESDFENLN 1118
Query: 1055 RKYTLKLNDWEEEKLRFLKQHPNFNNTYFIFPPNHALRRFCQRLVPPSYGKRTNNRVFFD 1114
+ +D EE K + + +T I P Q V P F +
Sbjct: 1119 TEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGE----QPEVEPEESLEPE-ACFTE 1173
Query: 1115 DTTNKV---------GQKRFFYNIEKDIFVFV------TFVATLLMVIYSCYV-TPLYRM 1158
D K G+ + ++N+ K + V TF+ ++++ +Y
Sbjct: 1174 DCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIE 1233
Query: 1159 NHNKKWNWTTYFEPVFVPLFTIEFLVKTIADGF-IYTPNAYCLNPWNRIDLVVLIALWID 1217
Y + VF +F +E L+K +A GF +Y NA+C W +D +++ +
Sbjct: 1234 QRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWC---W--LDFLIVDVSLVS 1288
Query: 1218 FFAWLLGNGELARIIKAVSALRALRFLTISSM--ARMTFKQVMFDGLTYIFGACAVAFSI 1275
A LG EL I K++ LRALR L S + + I V
Sbjct: 1289 LTANALGYSELGAI-KSLRTLRALRPLRALSRFEGMRAVVNALLGAIPSIMNVLLVCLIF 1347
Query: 1276 LFPYTVWGLNVFRGRLGVC---NDGDL-------SYGECYNEF-TNQVFHWDILMPRTYA 1324
+++ G+N+F G+ C G++ +Y EC +NQ W +
Sbjct: 1348 WLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVK----- 1402
Query: 1325 DPILHLNSFSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFL 1384
++ ++ + S+ ++ + +GW D++ + S V + + Y ++ ++F
Sbjct: 1403 ---VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIF 1459
Query: 1385 SMVFILNIFVSFIVGNNARMK-----GTAYLTLAEKSWLE-VKRLLSQVCPDPMPNVFKM 1438
F LN+F+ I+ N + K ++T +K + +K+L S+ P+P
Sbjct: 1460 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PA 1517
Query: 1439 NAVRRICYLWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFL 1498
N + + + + ++ F + + ++ L+++T+++ D ++ NI + + F+
Sbjct: 1518 NKFQGMVFDFVTKQ---VFDISIMILICLNMVTMMVETDDQSQEM---TNILYWINLVFI 1571
Query: 1499 LI---QEVMHIYGKSMR-LYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDV- 1553
++ + V+ + S+R Y WNIF VVV+ + +++ V + R +
Sbjct: 1572 VLFTGECVLKLI--SLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIR 1629
Query: 1554 -FQLGIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGP 1612
++G L +I + L+ SLP++F++ F++ +YAI F K
Sbjct: 1630 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1689
Query: 1613 NTTGNINCRTVTKSLILLFRCSFGEGWNYIMND-LTIEEPFCYSEAD--GSYT--DCGSK 1667
N T S+I LF+ + GW+ ++ L P C + D GS DCG+
Sbjct: 1690 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNP 1749
Query: 1668 AFAYALLMSWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREID 1727
+ +S+ IIS + +NM++++I+E FS E P S+++ F W + D
Sbjct: 1750 SVGIFFFVSYIIISFLVVLNMYIAVILENFSVA---TEESAEPLSEDDFEMFYEVWEKFD 1806
Query: 1728 PDGVGQFDVAYLPKFMHSFDGPL 1750
PD + A L F + D PL
Sbjct: 1807 PDATQFIEFAKLSDFADALDPPL 1829
Score = 103 bits (258), Expect = 2e-21
Identities = 116/562 (20%), Positives = 228/562 (39%), Gaps = 86/562 (15%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + ++W L+ L + ++ + Y ++ ++ R+L A R L+ + G+ ++
Sbjct: 1267 QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRAV 1326
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFC 531
+ AL IP ++NV + L FW+ F I+GV F G C+ + + +D+
Sbjct: 1327 VNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH-CINYTTGE-----MFDVSVV 1380
Query: 532 GGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVF 591
Y C A + A N +++FDN+ +
Sbjct: 1381 NNYSE------------------------CKALIESNQTARWKNVKVNFDNVGLGYLSLL 1416
Query: 592 VIMSANTFTDLMYFTMDT----------DNMAACLFFIVSILCLTVWMVNLLIAVLYSSF 641
+ + + D+MY +D+ DN+ L+F++ I+ + + +NL I V+ +F
Sbjct: 1417 QVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1476
Query: 642 EVVHEKY-TIDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFFV 699
+K+ D F T++ +N +K+L K PA +G+ + F
Sbjct: 1477 NQQKKKFGGQDIFMTEEQKKYYNAMKKLGS--KKPQKPIPRPANKFQGMVFDFVTKQVFD 1534
Query: 700 LAIFTSICA-LASMKSHSSDQSAQ---DIFSVNQIVSCILVVETILRLI----LYCKTPW 751
++I IC + +M + DQS + ++ +N + + E +L+LI Y W
Sbjct: 1535 ISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGW 1594
Query: 752 KFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLL----FFPISRFYRVVILFSVTR 807
++DF++ I+ V F + I S L I R R++ R
Sbjct: 1595 N-------IFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIR 1647
Query: 808 NLWKKVLKNAIVIWNLSAFYFLFVFLASLIVL---LYFDGTLDADDMEDTPFGFYSLPNA 864
L ++ + ++N+ FL +F+ ++ + Y + DDM F F + N+
Sbjct: 1648 TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDM----FNFETFGNS 1703
Query: 865 FLTLIKIASTENWTDSLYALQRDSP----------------TLFSALFGSVLLILWFILS 908
+ L +I ++ W L + P + G + + I+S
Sbjct: 1704 MICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIIS 1763
Query: 909 NFVVLNVFVAVIAASFDIEEED 930
VVLN+++AVI +F + E+
Sbjct: 1764 FLVVLNMYIAVILENFSVATEE 1785
>CE23561 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1687
Score = 172 bits (435), Expect = 6e-42
Identities = 171/779 (21%), Positives = 336/779 (42%), Gaps = 74/779 (9%)
Query: 1066 EEKLRFLKQHPNFNNTYFIFPPNHALRRFCQRLVPPSYGKRTNNRVFFDDTTNKVGQKRF 1125
EE++R + HP F+ F+ +LRR CQ + ++R +D + +
Sbjct: 762 EEEMR--ENHPMFDRPLFLVGRESSLRRMCQLIA--------HSRHSYDQNDGQHRKHSN 811
Query: 1126 FYNIEKDIFVFVTFV--ATLLMVIYSC----YVTPLYRMNHNKKWN--WTTYFEPVFVPL 1177
Y D +T++ +L+ SC + +P N +N + E +FV +
Sbjct: 812 KYKQFHDFLAIMTYMDWTMVLVTTLSCCSMLWESPWPTTGENLIFNNFYLQIAEYIFVLV 871
Query: 1178 FTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGEL---ARIIKA 1234
+ E +VK IA+G +TP A + + + + + I + F W+ + E+ A+++
Sbjct: 872 MSFELIVKCIANGLFFTPKALVTDVGDILTIFIYITSLM-FLIWMPNHIEINSWAQLLMV 930
Query: 1235 VSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRLGVC 1294
A+R LR + R ++ G I + ++F + +G+ + G+L C
Sbjct: 931 CRAMRPLRVYALIPHIRRVVVELC-RGFREILLVTILLVVLMFIFASFGVQLVGGKLASC 989
Query: 1295 NDGDLSYGE-CYNEFTNQVF--------------HWDILMPRTYADPI-LHLNSFSSAFR 1338
ND ++ E C + ++F H I++PR + +P + + +A
Sbjct: 990 NDPMITSRENCTGLYDVKLFVTRMEVYGKNDNLMHPSIIVPRVWTNPRNFNFDHIGNAML 1049
Query: 1339 SMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIV 1398
+++E +S +GW + + G ++ +F+ ++ F+ + L +FV +V
Sbjct: 1050 ALFETLSYKGWNVVRDVLYLRHGA----------WAVLFIHIYVFIGCMIGLTLFVGVVV 1099
Query: 1399 GNNARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFY-- 1456
N +GTA LT+ ++ W ++K L P +P +A R CYL+ + ++
Sbjct: 1100 ANYTENRGTALLTVDQRRWHDLKARLKMAQPLHVPPKPPESAKLR-CYLYDLTTSRWFKQ 1158
Query: 1457 -FSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYA 1515
F+VL+ + ++ +S++Q + + ++ ++ + ++ +
Sbjct: 1159 LFAVLVVVNSFTLVIPWNVSEEQDRKTFLLCLTVISAICNILFTLECLLKMIAFTLSGFW 1218
Query: 1516 RKRWNIFRCVVVMFAFATNIYELIVD---HVVVGISNARDVFQLGIFLLVI-------PQ 1565
+ R N ++ + ++ + + GI+ + + +L+VI +
Sbjct: 1219 QSRRNRIDFIITILGINWIVFHFLFQLPAYFAGGITEWKRLTYTYGYLVVILRFFTIAGR 1278
Query: 1566 NDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTK 1625
TL LM T S+ ++ F+L L YA A +FG+ K G ++N R +
Sbjct: 1279 KSTLKMLMLTVVMSMVRSSFIIAAMFLLVLFYANAGVVLFGMVKYGQAVGKHVNFRNGRE 1338
Query: 1626 SLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSY--TDCGSKAFAYALLMSWNIISMY 1683
+L++LFR GE WN IM+D PFC SY TDCG+ A S+ +I Y
Sbjct: 1339 ALVVLFRSVTGEDWNDIMHDCMRAPPFCNWHPGLSYWQTDCGNYVGAIVYFCSFYLIITY 1398
Query: 1684 IFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFM 1743
I +N+ V++I+E FS Y EE+ + S ++R F++ W +D + V + +
Sbjct: 1399 IVLNLLVAIIMENFSLFYSSEED--ALLSYADIRNFQLVWNMVDIEQKRSIPVRRVKFLL 1456
Query: 1744 HSFDGPLSFKIWEGRLTVKSLVSKYMKVNPNDPYDVEIDHFGLSKELSSIDYQKVNARR 1802
G L L K + + +++ D DV L+ + Y+ V+ R+
Sbjct: 1457 RLLKGRLEVNDESDGLLFKHMCHEMERLHNGD--DVSFHDV-----LNMLSYRSVDIRK 1508
Score = 80.1 bits (196), Expect = 3e-14
Identities = 117/540 (21%), Positives = 230/540 (41%), Gaps = 84/540 (15%)
Query: 447 LRLFRSLMAFRILKLVDLDSGLVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKG 506
LR RS++ F++ K I +K ++ NV ++F + I+GVQ F G
Sbjct: 95 LRFIRSIVRFKLPKN--------RIKLIIKRSSQQIQNVTIFFMFFVFSYAIMGVQLF-G 145
Query: 507 SLKRQCVWFNPNDPSDYYQYDMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSK 566
L CV N DP++ D+ +T+ K A G+ CP N
Sbjct: 146 RLNYHCV-VNGTDPNNVTIADLAI------PDTMCSQKG----------AGGYECPGNMV 188
Query: 567 CIS-----NANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVS 621
C+ + G+ F + +S+ V++ S + ++Y +D+ F+ V+
Sbjct: 189 CMRLQLKPQEEGFYGQ--FSDFASSLFTVYLAASQEGWVYVLYDCLDSLPSFLAFFYFVT 246
Query: 622 ILCLTVWMV-NLLIAVLYSSFEVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKS 680
++ W+V N+ IAV+ +F + +++ + + T++ H+ K + +
Sbjct: 247 LIFFLAWLVKNVFIAVITETFAEIRVQFS-EMWQTRE-------ATTDHVYTQKLEKDED 298
Query: 681 PAWAERGIRLYEKLEW---FFVLAIFTS--------ICALASMKSHS--------SDQSA 721
W + Y + F+ I TS + LA+ H+ SDQ
Sbjct: 299 -GWKLVEVDKYNRAHSNNSLFLHTIVTSTAFQTVMQLLILANAIFHATFVFYHDESDQIR 357
Query: 722 QDIFSVNQIVSCILV-VETILRLILYCKTPWK-FLAKPNYVYDFIISIICAVLSFNSLRI 779
+ + ++ IL E I+++ + WK ++A+ + +D I+C S N++ +
Sbjct: 358 KIWYYYVEVGFTILFNTEVIIKIYAF---GWKAYIARGQHKFD---CILCVGSSLNAIWV 411
Query: 780 SLGQTSAWLLFFPISRFYRVVILFSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVL 839
L +T+ + +F + R R++ + + K+ + L F + + + S I L
Sbjct: 412 -LYETNIFT-YFQVFRIARLIKASPMLEDFVYKIFGPGKKLGGLVIFTGILLIVTSAISL 469
Query: 840 LYFDGTLDADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSLYALQRDSPTLFSALFGSV 899
F + F + AF+++ +I + E WTD + + R + F ++
Sbjct: 470 QLFCYVPKLNK-------FTNFAVAFMSMFQIITQEGWTDVVIEILRACNEQ-AVPFVAI 521
Query: 900 LLILWFILSNFVVLNVFVAVIAASFDIEEEDKRLLQIK----HYLKVTYPERIREFSVVP 955
+ + +L VL++FVAVI + +++EE K++ Q+K +K T P R+R F+ P
Sbjct: 522 YFVAYHLLVTLFVLSLFVAVILDNLEMDEELKKVKQLKAREQDTIKTTLPMRLRIFNRFP 581
Score = 52.8 bits (125), Expect = 6e-06
Identities = 54/240 (22%), Positives = 93/240 (38%), Gaps = 59/240 (24%)
Query: 1166 WTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGN 1225
W Y E F LF E ++K A G+ AY ++ D ++ +
Sbjct: 360 WYYYVEVGFTILFNTEVIIKIYAFGW----KAYIARGQHKFDCILCV------------- 402
Query: 1226 GELARIIKAVSALRALRFLTISSMARMTFKQVMFDGLTY-IFGACAVAFSILFPYTVWGL 1284
G I + + + +AR+ M + Y IFG + GL
Sbjct: 403 GSSLNAIWVLYETNIFTYFQVFRIARLIKASPMLEDFVYKIFGPGK---------KLGGL 453
Query: 1285 NVFRGRLGVCNDGDLSYGECY----NEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSM 1340
+F G L + CY N+FTN F+ AF SM
Sbjct: 454 VIFTGILLIVTSAISLQLFCYVPKLNKFTN----------------------FAVAFMSM 491
Query: 1341 YEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGN 1400
++I++ EGWTD++ ++ + A P+ I+ + ++ L +F+L++FV+ I+ N
Sbjct: 492 FQIITQEGWTDVVIEILRACNEQ------AVPFVAIYFVAYHLLVTLFVLSLFVAVILDN 545
>CE29574 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1615
Score = 170 bits (431), Expect = 2e-41
Identities = 165/677 (24%), Positives = 292/677 (42%), Gaps = 82/677 (12%)
Query: 1066 EEKLRFLKQHPNFNNTYFIFPPNHALRRFCQRLVPPSYGKRTNNRVFFDDTTNKVGQKRF 1125
EE +R + HP F+ F+ LR FC+++V Y + D T K+
Sbjct: 948 EEDMR--ENHPFFDRPLFLVGRASQLREFCKKMVHSKYDSQD------DGTNGGAKTKKR 999
Query: 1126 FYNIEKDIFVF---------VTFVATLLMVIYSCYVTPLYRMNHNKKW-NWTTYFEPVFV 1175
F I I + VT V+ + M+ S + T + N + + YF FV
Sbjct: 1000 FKEIRALIGIMPYIDWAMATVTIVSCISMLFESPWPTTGENLVMNNGYLQISDYF---FV 1056
Query: 1176 PLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGE---LARII 1232
T E VK IA+G +TP A + ++L + I F AW+ + E LA+ +
Sbjct: 1057 LSMTFELCVKIIANGLFFTPKAVVRDVGGVMNLFIYFTSVI-FLAWMPKHVEINSLAQFL 1115
Query: 1233 KAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRLG 1292
A+R LR T+ R + F G I + ++F + +G+ + G+L
Sbjct: 1116 MICRAMRPLRIYTLVPHIRRVVLE-FFRGFKEILLVTILMIVVMFIFASFGVQIVGGKLA 1174
Query: 1293 VCNDGDLSYGE-CYNEFTNQVF--------------HWDILMPRTYADPI-LHLNSFSSA 1336
CND +S E C F ++F H I++PR + +P + + +A
Sbjct: 1175 ACNDPTVSSRENCTGVFWQKLFVTRLEVYGKDTEAMHPKIMVPRVWTNPRNFNFDHVGNA 1234
Query: 1337 FRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSF 1396
+++E +S +GW + + S G P++ +F+ ++ F+ + L +FV
Sbjct: 1235 MLALFETLSFKGWNVIRDILWSRHG----------PWAVVFIHIYVFIGCMIGLTLFVGV 1284
Query: 1397 IVGNNARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFY 1456
++ N + +GTA LT+ ++ W ++K L P +P +A R R +
Sbjct: 1285 VIANYTQNRGTALLTVDQRRWHDLKARLKMAQPLHVPPKPSESARLRTKLYDLTMSR--W 1342
Query: 1457 FSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFL--------LIQEVMHIYG 1508
F+ ++ L+ TL++ P+ Q ++ T + L +I+ ++ +
Sbjct: 1343 FNQAFALLVVLNSFTLVI----PWNVEEEEQRATYVFTVTALAAFMNMLFVIEIILKVIA 1398
Query: 1509 KSMRLYARKRWN-------IFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLL 1561
+ + + R N +F + + F + +D V V + + + G ++
Sbjct: 1399 YTFSGFWQSRRNRVDLLITVFGVIWIFLHFFVALPSSKID-VDVQVELKKFTYTFGYLVV 1457
Query: 1562 VI------PQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTT 1615
++ +N TL LM T S+ F ++ F+L L YA +F + K G +
Sbjct: 1458 ILRFFTIASRNSTLKMLMLTVIMSMFRSFFIITALFLLVLFYAYTGVILFPMVKYGMAVS 1517
Query: 1616 GNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSY--TDCGSKAFAYAL 1673
++N RT +++L++LFRC GE WN IM+D PFCY +Y TDCG+ A
Sbjct: 1518 KHVNFRTASEALVVLFRCLTGEDWNDIMHDCMRSAPFCYWNEGMNYWETDCGNFYGAIIY 1577
Query: 1674 LMSWNIISMYIFVNMFV 1690
S+ +I YI N+ V
Sbjct: 1578 FCSFYLIITYIVRNLLV 1594
Score = 74.3 bits (181), Expect = 2e-12
Identities = 130/637 (20%), Positives = 256/637 (39%), Gaps = 106/637 (16%)
Query: 451 RSLMAFRILKLVDLDSGLV----SILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKG 506
RS+ F I++L+ L I + LK ++ NV ++F + I G+Q F G
Sbjct: 219 RSIRPFIIIRLIPLVVKFKLPKNRIEQLLKRSSQQVKNVTLFFVFFMTLYAIFGIQLF-G 277
Query: 507 SLKRQCVWFNPNDPSDYYQYDMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSK 566
+ CV DP++ D+ E + G+ CPA
Sbjct: 278 RMDYHCVQ-PKTDPNNVTIMDLAIPDTMCAPEGIG----------------GYECPAPMV 320
Query: 567 CIS---NANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSIL 623
C+ NA F++ S+ V++ S + ++Y MD+ + +++
Sbjct: 321 CMQLNLNAKGEGFYGMFNDFGASVFTVYLAASEEGWVYVLYDCMDSLPSYLAFLYFCTLI 380
Query: 624 CLTVWMV-NLLIAVLYSSFEVVHEKY---------TIDKF------STQDNYLVFNV--- 664
W+V N+ IAV+ +F + ++ T+D+ T D + + +
Sbjct: 381 FFLAWLVKNVFIAVITETFAEIRVQFSEMWQKKEVTLDEGFRKKLEKTDDGWRLIRLDGE 440
Query: 665 ----------KRLAHLIKSKS--DTTKSPAWAERGIR--LYEKLEWFF------------ 698
+ ++ L++ S + K+ +A++ R Y+ E FF
Sbjct: 441 VEPEGPKQKLQWVSSLLRVNSVVEKKKNDTYAKKLARSAYYKNYEQFFPNPIIKTFFQML 500
Query: 699 -------VLAIFTSICALASM----KSHSSDQSAQDIFSVNQIVSCILV-VETILRLILY 746
+ IF I A+ + + +D+ + F + ++ IL VE I++++ Y
Sbjct: 501 RSMYFQCFVIIFVVINAIGNAMFVYRHDETDKPRKYNFYLFEVGFTILFNVECIIKILCY 560
Query: 747 CKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVT 806
F+ + + ++ I+ C S N ++ + + +F R R++ +
Sbjct: 561 GFR--NFIRRGIFKFELIL---CLGSSLNCVKFFYERN--YFTYFQTFRLLRLIKASPIL 613
Query: 807 RNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFL 866
+ K+ + L F F+ S I L F + F + P AF+
Sbjct: 614 EDFVWKIFSPGKKLGGLVIFTIAFICCYSAISLQLFYSVPNLHH-------FRTFPQAFM 666
Query: 867 TLIKIASTENWTDSLYALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAVIAASFDI 926
++ +I + E WTD + + R + L ++ + + + +VL++FVAVI + ++
Sbjct: 667 SMFQIITQEGWTDFVVEVLRATDDNLVPLV-ALYFVAYHLFVTLIVLSLFVAVILDNLEM 725
Query: 927 EEEDKRLLQIK-----HYLKVTYPERIREFSVVPLLERI--RRKFLRKPQIDDSEDFRQF 979
+EE K++ Q++ ++ T P R+R F P ++ RKF+ + DS DF
Sbjct: 726 DEELKKVKQLRAREATTSMRSTLPWRLRVFEKFPTRPQMAAMRKFVMFQYLADS-DFPMP 784
Query: 980 LFRGTAILSIAQNYEGFNMDLSEDKDHQFADRNVKSS 1016
RG+ A ++ D+ E D +F R +KS+
Sbjct: 785 KVRGSFTHQFAVDHSLETTDVIE-SDFEFPKRIMKSA 820
>7292723 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1848
Score = 161 bits (407), Expect = 1e-38
Identities = 161/647 (24%), Positives = 289/647 (43%), Gaps = 42/647 (6%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGN--G 1226
YF+ F +FTIE L+K + G I P +Y WN +D VV+I + F + G+ G
Sbjct: 804 YFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAG 863
Query: 1227 ELARIIKAVSALRALRFLTISSMARMTFKQVMFD----GLTYIFGACAVAFSILFPYTVW 1282
+ IK++ LR LR + ++ R+ + +FD L + V F ++V
Sbjct: 864 QNLSTIKSLRVLRVLR--PLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVI 921
Query: 1283 GLNVFRGRLGVCND-GDLSYGECYNEFTNQVFHWDILMP----RTYADPILHLNSFSSAF 1337
G+ +F G+ C D + EC + + D L+P R + H ++ ++A
Sbjct: 922 GVQLFNGKFFYCTDESKHTSAECQGSYFK--YEEDELLPKQELRVWKPRAFHYDNVAAAM 979
Query: 1338 RSMYEIVSLEGWTDLLQNMMSSTGVGT-PAELFASPYSGIFLILFNFLSMVFILNIFVSF 1396
+++ + + EGW +LQ+ M++T P + F S IF I++ + F +NIFV+
Sbjct: 980 LTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMS-IFYIVYFIVFPFFFVNIFVAL 1038
Query: 1397 IVGNNARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFY 1456
I+ + +G A L E + + + P+ N +W + +
Sbjct: 1039 II-ITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPF 1097
Query: 1457 FSVLMQFMLYLHILTLLMSKDQ--PYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLY 1514
+M +++ +L ++ +Q Y K N+ F T ++ V+ I G ++ +
Sbjct: 1098 EYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGF---TGMFSVETVLKIIGFGVKNF 1154
Query: 1515 ARKRWNIFRCVVVMFAFATNIY-ELIVDHVVVGISNARDVFQLGIFLLVIPQNDTLNELM 1573
+ WNIF + V+ + ++ E + + VG +F+ + ++ Q T+ L+
Sbjct: 1155 FKDPWNIFDLITVLGSIVDALWMEFGSNSINVGFLR---LFRAARLIKLLRQGYTIRILL 1211
Query: 1574 NTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGP---NTTGNINCRTVTKSLILL 1630
T S ++ + +LF +YAI QVFG KLG + T + N ++ + ++LL
Sbjct: 1212 WTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLL 1271
Query: 1631 FRCSFGEGWNYIMNDLTIEEPFCYSEAD---GSYTDCGSKAFAYALLMSWNIISMYIFVN 1687
FRC+ GE W IM ++ C +A+ G Y CGS AYA +S+ ++ +N
Sbjct: 1272 FRCATGEAWPNIML-ACLKGKACDDDAEKAPGEY--CGS-TLAYAYFVSFIFFCSFLMLN 1327
Query: 1688 MFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSFD 1747
+FV++I++ F Y+ S + +F W E DP+ G+ + + + D
Sbjct: 1328 LFVAVIMDNFDYL----TRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMD 1383
Query: 1748 GPLSF-KIWEGRLTVKSLVSKYMKVNPNDPYDVEIDHFGLSKELSSI 1793
PL F RL K L+ M ++ F L +E SI
Sbjct: 1384 PPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSI 1430
Score = 80.1 bits (196), Expect = 3e-14
Identities = 108/572 (18%), Positives = 221/572 (37%), Gaps = 94/572 (16%)
Query: 411 PRAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRIL---KLVDLDSG 467
P ++ R W ++ + I A +++G ++ L +SL R+L K +
Sbjct: 830 PGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPK 889
Query: 468 LVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYD 527
L ++ + + ++N+ + + F F ++GVQ F G +F D S + +
Sbjct: 890 LKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGK------FFYCTDESKHTSAE 943
Query: 528 MQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSM 587
Q G Y E E L P + ++ +DN+ +M
Sbjct: 944 CQ--GSYFKYEEDE------------------LLPKQELRVWKPRAFH----YDNVAAAM 979
Query: 588 ELVFVIMSANTFTDLMYFTMDTD----------NMAACLFFIVSILCLTVWMVNLLIAVL 637
+F + + + ++ +M + +F+IV + + VN+ +A++
Sbjct: 980 LTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALI 1039
Query: 638 YSSFEVVHEKYT----IDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEK 693
+F+ E IDK + L + +T K W I +
Sbjct: 1040 IITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWR---IVVSTP 1096
Query: 694 LEWFFVLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLI-----LYCK 748
E+F ++ I + L + D + + +N + + VET+L++I + K
Sbjct: 1097 FEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFK 1156
Query: 749 TPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVTRN 808
PW ++D +I+++ +++ ++L + G S + F + R R++
Sbjct: 1157 DPWN-------IFD-LITVLGSIV--DALWMEFGSNSINVGFLRLFRAARLI-------K 1199
Query: 809 LWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFD---------GTLDADDMEDTPF--- 856
L ++ I++W + ++ LI +L+F G + +E++
Sbjct: 1200 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHN 1259
Query: 857 GFYSLPNAFLTLIKIASTENWTDSLYALQR------DSPTLFSALFGSVLLILWFI---- 906
F S + L + A+ E W + + A + D+ GS L +F+
Sbjct: 1260 NFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIF 1319
Query: 907 LSNFVVLNVFVAVIAASFDIEEEDKRLLQIKH 938
+F++LN+FVAVI +FD D +L H
Sbjct: 1320 FCSFLMLNLFVAVIMDNFDYLTRDSSILGAHH 1351
Score = 72.0 bits (175), Expect = 9e-12
Identities = 60/238 (25%), Positives = 110/238 (46%), Gaps = 21/238 (8%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSIL 472
++ R+ W ++ ++ ++ I D LR R++ R LKLV L +L
Sbjct: 103 SYLRNIWNIMDFFVVVTGFMTQYPQIGPEVD---LRTLRAIRVLRPLKLVSGIPSLQVVL 159
Query: 473 RALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCG 532
+++ + LL +G ++L+ V F I+G++ + G+L + C ++ DP+ +
Sbjct: 160 KSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC--YSLEDPNKLVK------- 210
Query: 533 GYLNAETLEPMKYVFADNSEGPLAKGFLC-PANSKCISN-ANPYNGRISFDNIVNSMELV 590
E+ P DN F+C S C+ P +G SFDNI +M V
Sbjct: 211 ---EGESETPCN---TDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTV 264
Query: 591 FVIMSANTFTDLMYFTMDTDNMA-ACLFFIVSILCLTVWMVNLLIAVLYSSFEVVHEK 647
F ++ +T ++Y+T D A ++F+ I+ + +M+NL++ VL F EK
Sbjct: 265 FQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREK 322
Score = 58.2 bits (139), Expect = 1e-07
Identities = 69/300 (23%), Positives = 128/300 (42%), Gaps = 32/300 (10%)
Query: 1448 WAVEKRNFYF---SVLMQ----FMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFL-- 1498
W EKR ++ +V Q F++ L L + + YG+ + FL
Sbjct: 424 WRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGL 483
Query: 1499 -LIQEVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVV---VGISNARDVF 1554
+ + + +Y R+Y +N F CVV+ + +I+E+I V G+S R +
Sbjct: 484 FMSEMFIKMYALGPRIYFESSFNRFDCVVI----SGSIFEVIWSEVKGGSFGLSVLRALR 539
Query: 1555 QLGIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNT 1614
L IF V +L L+ + S+ SI SL++ F+ L++A+ Q+FG P
Sbjct: 540 LLRIFK-VTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGG 598
Query: 1615 TGNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALL 1674
T N T +L+ +F+ GE WN +M I + G+ + L+
Sbjct: 599 TPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQ-------GGAQKGMIYSIYFIVLV 651
Query: 1675 MSWNIISMYIFVNMFVSLIVEKFSYVYH---REENKHSPASQEEVRKFKVAWREIDPDGV 1731
+ N Y +N+F+++ V+ + EE + ++++++ + + DGV
Sbjct: 652 LFGN----YTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGV 707
>Hs4506813 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1977
Score = 159 bits (403), Expect = 3e-38
Identities = 237/1145 (20%), Positives = 477/1145 (40%), Gaps = 132/1145 (11%)
Query: 680 SPAWAERGIRLYEKLEWFFVLAIFT----SICALAS-----MKSHSSDQSAQDIFSVNQI 730
SP W + ++K +F V+ F +IC + + M+ H + +++ ++ +
Sbjct: 716 SPYWIK-----FKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNL 770
Query: 731 V-SCILVVETILRLILYCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLL 789
V + I E +L+LI P+++ ++D +I LS L ++ + + L
Sbjct: 771 VFTGIFAAEMVLKLI--AMDPYEYFQVGWNIFDSLI----VTLSLVELFLADVEGLSVLR 824
Query: 790 FFPISRFYRVVILFSVTRNLWKKVLKNAI-VIWNLSAFYFLFVFLASLIVLLYFDGTLDA 848
F + R +++ + T N+ K++ N++ + NL+ + VF+ +++ + F +
Sbjct: 825 SFRLLRVFKLAKSWP-TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKE 883
Query: 849 ------DDMEDTPFGFYSLPNAFLTLIKIASTENWTDSLYALQRDSPTLFSALFGSVLLI 902
DD + ++FL + ++ E W ++++ D + ++ +
Sbjct: 884 CVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMW----DCMEVAGQAMCLIVYM 938
Query: 903 LWFILSNFVVLNVFVAVIAASFD------IEEE-DKRLLQIKHYLKVTYPERIREFSVVP 955
+ ++ N VVLN+F+A++ +SF IEE+ D LQI VT ++ +
Sbjct: 939 MVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIA----VTRIKKGINYVKQT 994
Query: 956 LLERIRRKFLRKPQID----DSEDFRQFLFRGTAILSIAQNYEGFNMDLSEDKDHQFADR 1011
L E I + F +KP+I +ED + ++A+ +G N +DK F
Sbjct: 995 LREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFG-- 1052
Query: 1012 NVKSSFWNRILWRLKALNFYKTNPFFKDPKVVFVQSDDTTPSNRKYTLKLNDWEEEKLRF 1071
SS ++ +F NP + D N + +D E K+R
Sbjct: 1053 ---SSVDKHLMEDSDGQSFIH-NPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRL 1108
Query: 1072 LKQHPNFNNTYFIFPPNHALRRFCQRLVPPS----YGKRTNNRVFFDDTTNKVGQKRFFY 1127
+ + +T P + + + R + G+ + ++
Sbjct: 1109 NRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWW 1168
Query: 1128 NIEKDIFVFV------TFVATLLMVIYSCYVTPLYRMNHNKKWNWTT-YFEPVFVPLFTI 1180
NI K + V +F+ ++++ + K Y + +F +F +
Sbjct: 1169 NIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFIL 1228
Query: 1181 EFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELARIIKAVSALRA 1240
E L+K IA G+ Y N W +D +++ + A LG +L I K++ LRA
Sbjct: 1229 EMLLKWIAYGY----KTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPI-KSLRTLRA 1283
Query: 1241 LRFLTISSMARMTFKQVMFDGLT----YIFGACAVAFSILFPYTVWGLNVFRGRLGVC-- 1294
LR + +++R +V+ + L I V +++ G+N+F G+ C
Sbjct: 1284 LR--PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECIN 1341
Query: 1295 -NDGDL-------SYGECYNEFT-NQVFHWDILMPRTYADPILHLNSFSSAFRSMYEIVS 1345
DG + EC+ +Q W L ++ ++ + S+ ++ +
Sbjct: 1342 TTDGSRFPASQVPNRSECFALMNVSQNVRWKNLK--------VNFDNVGLGYLSLLQVAT 1393
Query: 1346 LEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNARMK 1405
+GWT ++ + S V + S Y I+ ++F F LN+F+ I+ N + K
Sbjct: 1394 FKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQK 1453
Query: 1406 GTA-----YLTLAEKSWLE-VKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFSV 1459
++T +K + +K+L S+ P+P N ++ C V + F S+
Sbjct: 1454 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PGNKIQG-CIFDLVTNQAFDISI 1510
Query: 1460 LMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLI---QEVMHIYGKSMR-LYA 1515
++ ++ L+++T+++ K+ G+ + + + F+++ + V+ + S+R Y
Sbjct: 1511 MV--LICLNMVTMMVEKE---GQSQHMTEVLYWINVVFIILFTGECVLKLI--SLRHYYF 1563
Query: 1516 RKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDV--FQLGIFLLVIPQNDTLNELM 1573
WNIF VVV+ + +++ V + R + ++G L ++ + L+
Sbjct: 1564 TVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLL 1623
Query: 1574 NTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKSLILLFRC 1633
SLP++F++ F++ +YAI F K N T S+I LF+
Sbjct: 1624 FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQI 1683
Query: 1634 SFGEGWNYIMND-LTIEEPFC-------YSEADGSYTDCGSKAFAYALLMSWNIISMYIF 1685
+ GW+ ++ L + P C S +G DCG+ + +S+ IIS +
Sbjct: 1684 TTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEG---DCGNPSVGIFYFVSYIIISFLVV 1740
Query: 1686 VNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHS 1745
VNM++++I+E FS E P S+++ F W + DPD + + L F +
Sbjct: 1741 VNMYIAVILENFSVA---TEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAA 1797
Query: 1746 FDGPL 1750
D PL
Sbjct: 1798 LDPPL 1802
Score = 92.4 bits (228), Expect = 6e-18
Identities = 118/559 (21%), Positives = 219/559 (39%), Gaps = 80/559 (14%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + ++W L+ L + + + Y D+ ++ R+L A R L+ + G+ +
Sbjct: 1240 KTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVV 1299
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFC 531
+ AL IP ++NV + L FW+ F I+GV F G +C+ N D S +
Sbjct: 1300 VNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY-ECI--NTTDGSRF-------- 1348
Query: 532 GGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVF 591
P V + SE C A N N +++FDN+ +
Sbjct: 1349 ----------PASQV-PNRSE--------CFALMNVSQNVRWKNLKVNFDNVGLGYLSLL 1389
Query: 592 VIMSANTFTDLMYFTMDTDN----------MAACLFFIVSILCLTVWMVNLLIAVLYSSF 641
+ + +T +MY +D+ N + ++F+V I+ + + +NL I V+ +F
Sbjct: 1390 QVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNF 1449
Query: 642 EVVHEKYT-IDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFFV 699
+K D F T++ +N +K+L K P +G F
Sbjct: 1450 NQQKKKLGGQDIFMTEEQKKYYNAMKKLGS--KKPQKPIPRPGNKIQGCIFDLVTNQAFD 1507
Query: 700 LAIFTSIC----ALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLI----LYCKTPW 751
++I IC + K S + ++ +N + + E +L+LI Y W
Sbjct: 1508 ISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGW 1567
Query: 752 KFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLL----FFPISRFYRVVILFSVTR 807
++DF++ II V F + I S L I R R+V R
Sbjct: 1568 N-------IFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIR 1620
Query: 808 NLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLT 867
L ++ + ++N+ FL +F+ ++ + F D + D F F + N+ +
Sbjct: 1621 TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDM-FNFETFGNSMIC 1679
Query: 868 LIKIASTENWTDSLYALQRDSPT----------------LFSALFGSVLLILWFILSNFV 911
L +I ++ W L + P + G + + I+S V
Sbjct: 1680 LFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLV 1739
Query: 912 VLNVFVAVIAASFDIEEED 930
V+N+++AVI +F + E+
Sbjct: 1740 VVNMYIAVILENFSVATEE 1758
Score = 73.2 bits (178), Expect = 4e-12
Identities = 60/235 (25%), Positives = 113/235 (47%), Gaps = 17/235 (7%)
Query: 414 FTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILR 473
F R W L+ + + A+L +++ + V LR FR L R LK + + GL +I+
Sbjct: 183 FLRDPWNWLDFVVIVFAYLTEFVNLGN---VSALRTFRVL---RALKTISVIPGLKTIVG 236
Query: 474 ALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCGG 533
AL + +L +V + ++ F ++G+Q F G+LK +C + N + ++ + M
Sbjct: 237 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-FRNSLENNETLESIM----N 291
Query: 534 YLNAETLEPMKYVFADNSEGPLAKGF-----LCPANSKCIS-NANPYNGRISFDNIVNSM 587
L +E + + + S+ L GF CP C+ NP G SFD +
Sbjct: 292 TLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAF 351
Query: 588 ELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSFE 642
+F +M+ + + +L T+ +FF+V I + +++NL++AV+ ++E
Sbjct: 352 LALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYE 406
Score = 58.9 bits (141), Expect = 8e-08
Identities = 71/321 (22%), Positives = 132/321 (41%), Gaps = 58/321 (18%)
Query: 1145 MVIYSCYVTPLYRMNHNKKWNWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWN 1204
M+I +T M N +WT E F ++T E LVK +A GF + +PWN
Sbjct: 130 MLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWN 189
Query: 1205 RIDLVVLIALWIDFFAWLLGNGELARIIKAVSALRALRFL----TISSMARMTFKQVMFD 1260
+D VV++ ++ F LGN R + + AL+ + + TI + K++
Sbjct: 190 WLDFVVIVFAYLTEFV-NLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 248
Query: 1261 GLTYIFGACAVAFSILFPYTVWGLNVFRGRL-GVCNDGDLSYGECYNEFTN--------- 1310
+ +F C F+++ GL +F G L C L E N
Sbjct: 249 MILTVF--CLSVFALI------GLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR 300
Query: 1311 QVFHW-----DILM----------PRTYADPILHLN---------SFSSAFRSMYEIVSL 1346
+ F++ D L+ P Y + N +FS AF +++ +++
Sbjct: 301 KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQ 360
Query: 1347 EGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNARMKG 1406
+ W +L Q + + G Y IF ++ FL +++N+ ++ +V +
Sbjct: 361 DYWENLYQQTLRAAG---------KTYM-IFFVVVIFLGSFYLINLILA-VVAMAYEEQN 409
Query: 1407 TAYLTLAEKSWLEVKRLLSQV 1427
A + A++ LE +++L ++
Sbjct: 410 QANIEEAKQKELEFQQMLDRL 430
>7298274 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2516
Score = 159 bits (401), Expect = 6e-38
Identities = 155/657 (23%), Positives = 287/657 (43%), Gaps = 74/657 (11%)
Query: 1161 NKKWNWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFA 1220
NK N YF F +FTIE ++K I+ GF+ A+C + +N +DL+V+ I
Sbjct: 1374 NKVLNKFDYF---FTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLIS--- 1427
Query: 1221 WLLGNGELARIIKAVSALRALRFLTISSMAR--MTFKQVMFDGLTYIFGACAVAFSILFP 1278
L+ + ++K + LR LR L + A+ Q + + I V + F
Sbjct: 1428 -LVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFM 1486
Query: 1279 YTVWGLNVFRGRLGVCNDGD-LSYGECYNE---FTNQVFHWDILMPRTYADPILHLNSFS 1334
+ V G+ +F+G+ C DG ++ ECY + + H L R +++ H + +
Sbjct: 1487 FAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVA 1546
Query: 1335 SAFRSMYEIVSLEGWTDLLQ-NMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIF 1393
+++ + + EGW LL ++ S+ G P F P + I++ + F++NIF
Sbjct: 1547 KGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNF-RPIVAAYYIIYIIIIAFFMVNIF 1605
Query: 1394 VSFIVGNNARMKGTAYLTLAEKSWLEVKRL-LSQVCPDPMPNVFKMNAVRRIC------- 1445
V F++ +T + E K L + + + K VRR
Sbjct: 1606 VGFVI-----------VTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQY 1654
Query: 1446 -YLWAVEKRNFYFSVLMQFMLYLHILTLLMS-KDQP--YGKLPTNQNIQFMVTTSFLLIQ 1501
W V +F +++ + ++ ++ +TL M +QP Y +L N M+ T+ ++
Sbjct: 1655 KVWWFVTSSSFEYTIFI--LIMINTVTLAMKFYNQPLWYTELLDALN---MIFTAVFALE 1709
Query: 1502 EVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVD---------HVVVGISNARD 1552
V + + Y WN+F ++V+ +F +Y I +V G + +
Sbjct: 1710 FVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKK 1769
Query: 1553 -------------VFQLGIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAI 1599
+F++ + ++ + + + L+ T S ++ + +LF +YA+
Sbjct: 1770 SAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAV 1829
Query: 1600 ALNQVFGVTKL--GPNTTGNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIE-EPFCYSE 1656
QVFG L G T N N +T +++++LFR + GE W IM + + + C
Sbjct: 1830 VGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMN 1889
Query: 1657 ADGSYTDCGSKAFAYALLMSWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEV 1716
+D CGS + AY +S+ ++ ++ +N+FV++I++ F Y+ S +
Sbjct: 1890 SDTPGEPCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFDYL----TRDWSILGPHHL 1944
Query: 1717 RKFKVAWREIDPDGVGQFDVAYLPKFMHSFDGPLSF-KIWEGRLTVKSLVSKYMKVN 1772
+F W E DPD G+ + + PL F K+ R+ K LVS M +N
Sbjct: 1945 DEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLN 2001
Score = 105 bits (263), Expect = 6e-22
Identities = 141/654 (21%), Positives = 263/654 (39%), Gaps = 115/654 (17%)
Query: 1143 LLMVIYSCYVTPLYRMNHNKKWNWTTY----FEPVFVPLFTIEFLVKTIADGFIYTPNAY 1198
LL + +C +Y N T E VF+ +FT E ++K +A GF+ AY
Sbjct: 622 LLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAY 681
Query: 1199 CLNPWNRIDL-VVLIALWIDFFAWLLGNGELARIIKAVSALRALRFLTISSMARMTFKQV 1257
N WN +D +V+I + L+ + + ++A LR LR ++ ++ +
Sbjct: 682 LRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSI 741
Query: 1258 MFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRL-GVCNDGDLSYGECYNEFTNQVFHWD 1316
+ + +F + ++ Y + GL +F G+L C D E E+ +
Sbjct: 742 L-KAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRD------EITGEYEENIRPCG 794
Query: 1317 I--LMPRTYA---------DPILHLNSFSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTP 1365
+ P Y D I + ++F A ++++ V+LEGWTD+L ++ + G
Sbjct: 795 VGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMG---- 850
Query: 1366 AELFASPYSGIFLILFNFLSMVFILNIFVSFIVG------NNARMKGTAYLTLAEKSWLE 1419
S + ++ I L F++N+ + + G N A+ +G + L EK +E
Sbjct: 851 -----SDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGD-FQKLREKQQIE 904
Query: 1420 --------------------VKRLLS-------------QVCPDPMPNVFKMNA------ 1440
V L+S + + MP V +
Sbjct: 905 EDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMK 964
Query: 1441 ---------VRRICYLWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQF 1491
+RR C AV+ + FY+ +++ L +L + YG+L N Q
Sbjct: 965 KDFDRVNRRMRRACRK-AVKSQAFYWLIIVLVFLNTGVLA-----TEHYGQLDWLDNFQE 1018
Query: 1492 MVTTSFL---LIQEVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGIS 1548
F+ + ++ +Y + Y +N F C VV+ + + +G+S
Sbjct: 1019 YTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVS 1078
Query: 1549 NARDVFQLGIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFG-- 1606
R V L +F V +L+ L+ + S+ SI SL+ F+ +++A+ QVFG
Sbjct: 1079 VLRCVRLLRVF-KVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGK 1137
Query: 1607 VTKLGPNTTGNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGS 1666
G +N ++L+ +F+ GE WN +M + A G + G+
Sbjct: 1138 FNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVM--------YVGINAYGGVSSYGA 1189
Query: 1667 KAFAYALLMSWNIISMYIFVNMFVSLIVEKFSYV-----YHREENKHSPASQEE 1715
A Y +++ I YI +N+F+++ V+ + +EE H ++Q++
Sbjct: 1190 LACIYFIILF--ICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKK 1241
Score = 73.9 bits (180), Expect = 2e-12
Identities = 130/623 (20%), Positives = 240/623 (37%), Gaps = 130/623 (20%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSIL 472
AF RS++ L+LL + ++ S N V LR+ R L R L+ ++ GL ++
Sbjct: 1407 AFCRSAFNLLDLLVVCVSLISLVSSSNAISVVKILRVLRVL---RPLRAINRAKGLKHVV 1463
Query: 473 RALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCG 532
+ + + + N+ + F ++GVQ FKG +F D S Q + C
Sbjct: 1464 QCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGK------FFKCTDGSKMTQDE---CY 1514
Query: 533 GYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVFV 592
G Y+ D+ + + + N R FD++ M +F
Sbjct: 1515 G----------TYLVYDDGD----------VHKPRLREREWSNNRFHFDDVAKGMLTLFT 1554
Query: 593 IMSANTFTDLMYFTMDTDNM----------AACLFFIVSILCLTVWMVNLLIAVLYSSF- 641
+ + + L+Y ++D++ ++I+ I+ + +MVN+ + + +F
Sbjct: 1555 VSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQ 1614
Query: 642 -EVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWF--- 697
E E D Q N + F +K+K P + GI+ K+ WF
Sbjct: 1615 NEGEQEYKNCDLDKNQRNCIEF-------ALKAKPVRRYIP---KHGIQY--KVWWFVTS 1662
Query: 698 -------FVLAIFTSICALASMKSHSSDQSAQDIF-SVNQIVSCILVVETILRLILYCKT 749
F+L + ++ +MK ++ ++ ++N I + + +E + +L +
Sbjct: 1663 SSFEYTIFILIMINTVTL--AMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFK 1720
Query: 750 PWKFLAKPNYVYDFII---SIICAVLS------------------FNSLRISLGQTSAWL 788
+ V+DFII S I V S S + S G +
Sbjct: 1721 --NYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISI 1778
Query: 789 LFFPISRFYRVVILFSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYF------ 842
FF + R R+V L S + ++W + ++A LIVLL+F
Sbjct: 1779 NFFRLFRVMRLVKLLSKGEGI-------RTLLWTFIKSFQALPYVALLIVLLFFIYAVVG 1831
Query: 843 -----DGTLDADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSLYA----------LQRD 887
LD + F + A L L + A+ E W + + + + D
Sbjct: 1832 MQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSD 1891
Query: 888 SP-TLFSALFGSVLLILWFILSNFVVLNVFVAVIAASFDIEEEDKRLLQIKH---YLKV- 942
+P + I +++L +F+++N+FVAVI +FD D +L H ++++
Sbjct: 1892 TPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLW 1951
Query: 943 -----TYPERIREFSVVPLLERI 960
RI+ VV LL +I
Sbjct: 1952 SEYDPDAKGRIKHLDVVTLLRKI 1974
Score = 68.2 bits (165), Expect = 1e-10
Identities = 59/240 (24%), Positives = 108/240 (44%), Gaps = 37/240 (15%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLS--INDYDDVHGLRLFRSLMAFRILKLV-DLDSGLV 469
A+ R+ W L+ + ++ LS + D DV LR FR L R++ V L L
Sbjct: 680 AYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLN 739
Query: 470 SILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQ 529
SIL+A+ +P L ++ ++L+ + + I+G++ F G L + C ++ + Y+ +++
Sbjct: 740 SILKAM---VP-LFHIALLVLFVIIIYAIIGLELFSGKLHKAC----RDEITGEYEENIR 791
Query: 530 FCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISN-ANPYNGRISFDNIVNSME 588
CG G+ CP KC P +G +FDN +M
Sbjct: 792 PCG------------------------VGYQCPPGYKCYGGWDGPNDGITNFDNFGLAML 827
Query: 589 LVFVIMSANTFTDLMYFTMDT-DNMAACLFFIVSILCLTVWMVNLLIAVLYSSFEVVHEK 647
VF ++ +TD++Y D + ++FI ++ +++NL++ VL F K
Sbjct: 828 TVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNK 887
>Hs4506809 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2016
Score = 158 bits (399), Expect = 9e-38
Identities = 136/603 (22%), Positives = 264/603 (43%), Gaps = 39/603 (6%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGEL 1228
Y + +F +F +E L+K +A GF Y N W +D +++ + A LG E+
Sbjct: 1241 YADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEM 1296
Query: 1229 ARIIKAVSALRALRFLTISSMARMTFKQVMFDGLT----YIFGACAVAFSILFPYTVWGL 1284
I K++ LRALR + +++R +V+ + L I V +++ G+
Sbjct: 1297 GPI-KSLRTLRALR--PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 1353
Query: 1285 NVFRGRLGVC---NDGDLSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMY 1341
N+F G+ G C +GDL +Q ++ + ++ ++ + + ++
Sbjct: 1354 NLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALL 1413
Query: 1342 EIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNN 1401
++ + +GW D++ + S G + + Y I+ ++F F LN+F+ I+ N
Sbjct: 1414 QVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF 1473
Query: 1402 ARMKGTA-----YLTLAEKSWLE-VKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNF 1455
+ K ++T +K + +K+L S+ P+P +N + + ++
Sbjct: 1474 NQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PLNKYQGFIFDIVTKQA-- 1529
Query: 1456 YFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLI--QEVMHIYGKSMRL 1513
F V + F++ L+++T+++ D + P NI + F+ I E +
Sbjct: 1530 -FDVTIMFLICLNMVTMMVETDD---QSPEKINILAKINLLFVAIFTGECIVKLAALRHY 1585
Query: 1514 YARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDV--FQLGIFLLVIPQNDTLNE 1571
Y WNIF VVV+ + + I+ + R + ++G L +I +
Sbjct: 1586 YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRT 1645
Query: 1572 LMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKSLILLF 1631
L+ SLP++F++ F++ +Y+I F K N +T S++ LF
Sbjct: 1646 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLF 1705
Query: 1632 RCSFGEGWNYIMND-LTIEEPFC---YSEADGSYTDCGSKAFAYALLMSWNIISMYIFVN 1687
+ + GW+ +++ L P+C ++GS DCGS A ++ IIS I VN
Sbjct: 1706 QITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVN 1765
Query: 1688 MFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSFD 1747
M++++I+E FS E P S+++ F W + DP+ + + L F +
Sbjct: 1766 MYIAIILENFSVA---TEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALS 1822
Query: 1748 GPL 1750
PL
Sbjct: 1823 EPL 1825
Score = 87.0 bits (214), Expect = 3e-16
Identities = 116/566 (20%), Positives = 222/566 (38%), Gaps = 95/566 (16%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + ++W L+ L + ++ + + ++ ++ R+L A R L+ + G+ +
Sbjct: 1264 KKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVV 1323
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFC 531
+ AL IP ++NV + L FW+ F I+GV F G R C+ D
Sbjct: 1324 VNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR-CINQTEGDL----------- 1371
Query: 532 GGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCIS---NANPY--NGRISFDNIVNS 586
P+ Y +N S+C S Y +++FDN+
Sbjct: 1372 ----------PLNYTIVNNK-------------SQCESLNLTGELYWTKVKVNFDNVGAG 1408
Query: 587 MELVFVIMSANTFTDLMYFTMDTD----------NMAACLFFIVSILCLTVWMVNLLIAV 636
+ + + + D+MY +D+ N+ ++F++ I+ + + +NL I V
Sbjct: 1409 YLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGV 1468
Query: 637 LYSSFEVVHEKYT-IDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLYEKL 694
+ +F +K D F T++ +N +K+L K P +G
Sbjct: 1469 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGS--KKPQKPIPRPLNKYQGFIFDIVT 1526
Query: 695 EWFFVLAIFTSICA-LASMKSHSSDQSAQDI---FSVNQIVSCILVVETILRLIL----Y 746
+ F + I IC + +M + DQS + I +N + I E I++L Y
Sbjct: 1527 KQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYY 1586
Query: 747 CKTPWKFLAKPNYVYDFII---SIICAVLSFNSLRISLGQTSAWLLFFP-ISRFYRVVIL 802
W ++DF++ SI+ VLS + T ++ I R R++
Sbjct: 1587 FTNSWN-------IFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRG 1639
Query: 803 FSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLL---YFDGTLDADDMEDTPFGFY 859
R L ++ + ++N+ FL +F+ S+ + Y DDM F F
Sbjct: 1640 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDM----FNFQ 1695
Query: 860 SLPNAFLTLIKIASTENWTDSLYALQRDSPTLF---------------SALFGSVLLILW 904
+ N+ L L +I ++ W L + P S G + +
Sbjct: 1696 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1755
Query: 905 FILSNFVVLNVFVAVIAASFDIEEED 930
I+S +V+N+++A+I +F + E+
Sbjct: 1756 IIISFLIVVNMYIAIILENFSVATEE 1781
Score = 74.3 bits (181), Expect = 2e-12
Identities = 62/237 (26%), Positives = 113/237 (47%), Gaps = 15/237 (6%)
Query: 414 FTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILR 473
F R W L+ I +AY D +V LR FR L R LK + + SGL +I+
Sbjct: 188 FLRDPWNWLDFSVII---MAYTTEFVDLGNVSALRTFRVL---RALKTISVISGLKTIVG 241
Query: 474 ALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCV--WFNPNDPSDYYQYDMQFC 531
AL + +L +V + ++ F ++G+Q F G+L+ +CV + N + + D
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD-GLV 300
Query: 532 GGYLNAETLEPMKYVFADNSEGPLAKG-----FLCPANSKCI-SNANPYNGRISFDNIVN 585
L+ +P Y+ + + L G CP +C+ + NP +G SFD+
Sbjct: 301 WESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAW 360
Query: 586 SMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSFE 642
+ +F +M+ + + L T+ + +FF++ I + ++VNL++AV+ ++E
Sbjct: 361 AFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
>Hs19923381 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2000
Score = 156 bits (394), Expect = 4e-37
Identities = 217/1093 (19%), Positives = 457/1093 (40%), Gaps = 99/1093 (9%)
Query: 711 SMKSHSSDQSAQDIFSVNQIV-SCILVVETILRLILYCKTPWKFLAKPNYVYDFIISIIC 769
+M+ + + + +V +V + I E +L++I P+ + + ++D II
Sbjct: 778 AMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKII--AMDPYYYFQEGWNIFDGII---- 831
Query: 770 AVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVTRNLWKKVLKNAI-VIWNLSAFYF 828
LS L +S + + L F + R +++ + T N+ K++ N++ + NL+
Sbjct: 832 VSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWP-TLNMLIKIIGNSVGALGNLTLVLA 890
Query: 829 LFVFLASLIVLLYFDGTLDA------DDMEDTPFGFYSLPNAFLTLIKIASTENWTDSLY 882
+ VF+ +++ + F + DD + ++FL + ++ E W ++++
Sbjct: 891 IIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMW 949
Query: 883 ALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAVIAASFDIE-----EEDKRLLQIK 937
D + ++ +L ++ N VVLN+F+A++ +SF + ++D + ++
Sbjct: 950 ----DCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQ 1005
Query: 938 HYLKVTYPERIREFSVVPLLERIRRKFLRKPQIDDSEDFRQFLFRGTAILSIAQNYEGFN 997
+ V ++ ++ + E ++ F RKP++ + + G I S N G
Sbjct: 1006 --IAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIE-------IHEGNKIDSCMSNNTGIE 1056
Query: 998 ----MDLSEDKDHQFADRNVKSSFWNRILWRLKALNFYKTNPFFKDPKVVFVQSDDTTPS 1053
++ D + + SS ++ ++F NP + V D
Sbjct: 1057 ISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFIN-NPSLTVTVPIAVGESDFENL 1115
Query: 1054 NRKYTLKLNDWEEEKLRFLKQHPNFNNTYFIFPPNHALRRFCQR---LVPPS-YGKRTNN 1109
N + ++ EE K + + +T + P + + P + + +
Sbjct: 1116 NTEEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDFKPEACFTEGCIK 1175
Query: 1110 RVFFDDTTNKVGQKRFFYNIEKDIFVFV------TFVATLLMVIYSCYV-TPLYRMNHNK 1162
+ F + + G+ + ++N+ K + V TF+ ++++ +Y
Sbjct: 1176 KFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKT 1235
Query: 1163 KWNWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWL 1222
Y + VF +F +E L+K +A GF Y N W +D +++ + A
Sbjct: 1236 IKTMLEYADKVFTYIFILEMLLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANA 1291
Query: 1223 LGNGELARIIKAVSALRALRFLTISSMARMTFKQVMFDGLT----YIFGACAVAFSILFP 1278
LG EL I K++ LRALR + +++R +V+ + L I V
Sbjct: 1292 LGYSELGAI-KSLRTLRALR--PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLI 1348
Query: 1279 YTVWGLNVFRGRLGVCNDGDLSYGECYN-EFTNQVFHWDILMPRT-YADPILHLNSFSSA 1336
+++ G+N+F G+ C + ++ G ++ N + L + + + ++ ++ +
Sbjct: 1349 FSIMGVNLFAGKFYHCVN--MTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAG 1406
Query: 1337 FRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSF 1396
+ ++ ++ + +GW D++ + S V + Y ++ ++F F LN+F+
Sbjct: 1407 YLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGV 1466
Query: 1397 IVGNNARMKGT-----AYLTLAEKSWLE-VKRLLSQVCPDPMPNVFKMNAVRRICYLWAV 1450
I+ N + K ++T +K + +K+L S+ P+P N + + + +
Sbjct: 1467 IIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PANKFQGMVFDFVT 1524
Query: 1451 EKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPT----NQNIQFMV--TTSFLLIQEVM 1504
+ F + + ++ L+++T+++ D GK T N+ F+V T F+L +
Sbjct: 1525 RQ---VFDISIMILICLNMVTMMVETDDQ-GKYMTLVLSRINLVFIVLFTGEFVLKLVSL 1580
Query: 1505 HIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDV--FQLGIFLLV 1562
Y Y WNIF VVV+ + +++ V + R + ++G L +
Sbjct: 1581 RHY------YFTIGWNIFDFVVVILSIVGMFLAEMIEKYSVSPTLFRVIRLARIGRILRL 1634
Query: 1563 IPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRT 1622
I + L+ SLP++F++ F++ +YAI F K N T
Sbjct: 1635 IKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFET 1694
Query: 1623 VTKSLILLFRCSFGEGWNYIMND-LTIEEPFCYSEA--DGSYT--DCGSKAFAYALLMSW 1677
S+I LF+ + GW+ ++ L P C + GS D G + +S+
Sbjct: 1695 FGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDRGDPSVGIFFFVSY 1754
Query: 1678 NIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVA 1737
IIS + VNM++++I+E FS E P S+++ F W + DPD + +
Sbjct: 1755 IIISFLVVVNMYIAVILENFSVA---TEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFS 1811
Query: 1738 YLPKFMHSFDGPL 1750
L F + D PL
Sbjct: 1812 KLSDFAAALDPPL 1824
Score = 91.3 bits (225), Expect = 1e-17
Identities = 112/559 (20%), Positives = 224/559 (40%), Gaps = 83/559 (14%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + ++W L+ L + ++ + Y ++ ++ R+L A R L+ + G+ +
Sbjct: 1265 QTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVV 1324
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFC 531
+ AL IP ++NV + L FW+ F I+GV F G +Y
Sbjct: 1325 VNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK---------------FYHCVNMTT 1369
Query: 532 GGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVF 591
G + + + C A K A N +++FDN+ +
Sbjct: 1370 GNMFDISDVNNLSD---------------CQALGK---QARWKNVKVNFDNVGAGYLALL 1411
Query: 592 VIMSANTFTDLMYFTMDT----------DNMAACLFFIVSILCLTVWMVNLLIAVLYSSF 641
+ + + D+MY +D+ +N+ L+F++ I+ + + +NL I V+ +F
Sbjct: 1412 QVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1471
Query: 642 EVVHEKYT-IDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFFV 699
+K+ D F T++ +N +K+L K PA +G+ F
Sbjct: 1472 NQQKKKFGGQDIFMTEEQKKYYNAMKKLGS--KKPQKPIPRPANKFQGMVFDFVTRQVFD 1529
Query: 700 LAIFTSICA-LASMKSHSSDQSAQDIFSVNQIVSCILVV---ETILRLI----LYCKTPW 751
++I IC + +M + DQ +++I +V+ E +L+L+ Y W
Sbjct: 1530 ISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGW 1589
Query: 752 KFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLL----FFPISRFYRVVILFSVTR 807
++DF++ I+ V F + I S L I R R++ R
Sbjct: 1590 N-------IFDFVVVILSIVGMFLAEMIEKYSVSPTLFRVIRLARIGRILRLIKGAKGIR 1642
Query: 808 NLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLT 867
L ++ + ++N+ FL +F+ ++ + F ++D F F + N+ +
Sbjct: 1643 TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDM-FNFETFGNSMIC 1701
Query: 868 LIKIASTENWTDSLYALQRDSP------TLFSAL----------FGSVLLILWFILSNFV 911
L +I ++ W L + +P T+ G + + I+S V
Sbjct: 1702 LFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDRGDPSVGIFFFVSYIIISFLV 1761
Query: 912 VLNVFVAVIAASFDIEEED 930
V+N+++AVI +F + E+
Sbjct: 1762 VVNMYIAVILENFSVATEE 1780
Score = 78.2 bits (191), Expect = 1e-13
Identities = 64/250 (25%), Positives = 114/250 (45%), Gaps = 27/250 (10%)
Query: 414 FTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILR 473
F R W L+ + +AY D +V LR FR L R LK + + GL +I+
Sbjct: 185 FLRDPWNWLDFSVIV---MAYVTEFVDLGNVSALRTFRVL---RALKTISVIPGLKTIVG 238
Query: 474 ALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPND------PSDYYQYD 527
AL + +L +V + ++ F ++G+Q F G+L+ +C+ + P+D + Y+
Sbjct: 239 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGT 298
Query: 528 MQFCGGYLNA--ETLEPMKYV-------FADNSEGPLAKG-----FLCPANSKCI-SNAN 572
M G ++N T Y+ D + PL G CP C+ + N
Sbjct: 299 MDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRN 358
Query: 573 PYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNL 632
P G SFD + +F +M+ + + +L T+ +FF++ I + ++VNL
Sbjct: 359 PNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNL 418
Query: 633 LIAVLYSSFE 642
++AV+ ++E
Sbjct: 419 ILAVVAMAYE 428
>Hs20536765 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1649
Score = 155 bits (391), Expect = 8e-37
Identities = 217/1081 (20%), Positives = 450/1081 (41%), Gaps = 101/1081 (9%)
Query: 728 NQIVSCILVVETILRLILYCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAW 787
N + + I E L++I P+ + + ++D I LS L ++ + +
Sbjct: 444 NLVFTGIFTAEMFLKII--AMDPYYYFQEGWNIFDGFI----VTLSLVELGLANVEGLSV 497
Query: 788 LLFFPISRFYRVVILFSVTRNLWKKVLKNAI-VIWNLSAFYFLFVFLASLIVLLYFDGTL 846
L F + R +++ + T N+ K++ N++ + NL+ + VF+ +++ + F +
Sbjct: 498 LRSFRLLRVFKLAKSWP-TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 556
Query: 847 D------ADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSLYALQRDSPTLFSALFGSVL 900
A D + + ++FL + ++ E W ++++ D + +
Sbjct: 557 KDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMW----DCMEVAGQAMCLTV 611
Query: 901 LILWFILSNFVVLNVFVAVIAASFDIE-----EEDKRL--LQI---KHYLKVTYPERIRE 950
++ ++ N VVLN+F+A++ +SF + ++D + LQI + + V Y +R
Sbjct: 612 FMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKR--- 668
Query: 951 FSVVPLLERIRRKFLRKPQI-DDSEDFRQFLFRGTAILSIAQNYEGFNMDLSEDKDHQFA 1009
+ E I++ F+RK +I D+ + + + +S G ++D +D + +
Sbjct: 669 ----KIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTS 724
Query: 1010 DRNVKSSFWNRILWRLKALNFYKTNPFFKDPKVVFVQSDDTTPSNRKYTLKLNDWEEEKL 1069
SS I+ ++F NP + V D N + +D EE K
Sbjct: 725 GIGTGSSVEKYIIDESDYMSFIN-NPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKE 783
Query: 1070 RFLKQHPNFN-NTYFIFPPNHALRRFCQRLVPPS--------YGKRTNNRVFFDDTTNKV 1120
+ + + +T I P Q +V P + + R +
Sbjct: 784 KLNESSSSSEGSTVDIGAPVEE-----QPVVEPEETLEPEACFTEGCVQRFKCCQINVEE 838
Query: 1121 GQKRFFYNIEKDIFVFV------TFVATLLMVIYSCYV-TPLYRMNHNKKWNWTTYFEPV 1173
G+ + ++N+ + F V TF+ ++++ +Y Y + V
Sbjct: 839 GRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKV 898
Query: 1174 FVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELARIIK 1233
F +F +E L+K +A G+ Y N W +D +++ + A LG EL I K
Sbjct: 899 FTYIFILEMLLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI-K 953
Query: 1234 AVSALRALRFLTISSMARMTFKQVMFDGLT----YIFGACAVAFSILFPYTVWGLNVFRG 1289
++ LRALR + +++R +V+ + L I V +++ G+N+F G
Sbjct: 954 SLRTLRALR--PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1011
Query: 1290 RLGVC---NDGDLSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMYEIVSL 1346
+ C GD E N T+ + + + + ++ ++ + S+ ++ +
Sbjct: 1012 KFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATF 1071
Query: 1347 EGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNARMK- 1405
+GW D++ + S V + S Y ++ ++F F LN+F+ I+ N + K
Sbjct: 1072 KGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1131
Query: 1406 ----GTAYLTLAEKSWLE-VKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFSVL 1460
++T +K + +K+L S+ P+P N + + + + + F +
Sbjct: 1132 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PGNKFQGMVFDFVTRQ---VFDIS 1186
Query: 1461 MQFMLYLHILTLLMSKDQPYGKLPT---NQNIQFMVTTSFLLIQEVMHIYGKSMRLYARK 1517
+ ++ L+++T+++ D + T N+ F+V + + +++ + Y
Sbjct: 1187 IMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL----RHYYFTI 1242
Query: 1518 RWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDV--FQLGIFLLVIPQNDTLNELMNT 1575
WNIF VVV+ + +++ V + R + ++G L +I + L+
Sbjct: 1243 GWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFA 1302
Query: 1576 ATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKSLILLFRCSF 1635
SLP++F++ F++ +YAI F K N T S+I LF+ +
Sbjct: 1303 LMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITT 1362
Query: 1636 GEGWNYIMND-LTIEEPFC----YSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMFV 1690
GW+ ++ L + P C + DCG+ + +S+ IIS + VNM++
Sbjct: 1363 SAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYI 1422
Query: 1691 SLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSFDGPL 1750
++I+E FS E P S+++ F W + DPD + L +F + + PL
Sbjct: 1423 AVILENFSVA---TEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPL 1479
Query: 1751 S 1751
+
Sbjct: 1480 N 1480
Score = 90.5 bits (223), Expect = 2e-17
Identities = 113/562 (20%), Positives = 225/562 (39%), Gaps = 86/562 (15%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + ++W L+ L + ++ + Y ++ ++ R+L A R L+ + G+ +
Sbjct: 917 QTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVV 976
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFC 531
+ AL IP ++NV + L FW+ F I+GV F G C+ D ++D++
Sbjct: 977 VNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH-CINTTTGD-----RFDIEDV 1030
Query: 532 GGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVF 591
+ + L + +E A N +++FDN+ +
Sbjct: 1031 NNHTDCLKL-------IERNE-----------------TARWKNVKVNFDNVGFGYLSLL 1066
Query: 592 VIMSANTFTDLMYFTMDTDNMAA----------CLFFIVSILCLTVWMVNLLIAVLYSSF 641
+ + + D+MY +D+ N+ L+F++ I+ + + +NL I V+ +F
Sbjct: 1067 QVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1126
Query: 642 EVVHEKYT-IDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFFV 699
+K+ D F T++ +N +K+L K P +G+ F
Sbjct: 1127 NQQKKKFGGQDIFMTEEQKKYYNAMKKLGS--KKPQKPIPRPGNKFQGMVFDFVTRQVFD 1184
Query: 700 LAIFTSICA-LASMKSHSSDQS---AQDIFSVNQIVSCILVVETILRLI----LYCKTPW 751
++I IC + +M + DQS + +N + + E +L+LI Y W
Sbjct: 1185 ISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGW 1244
Query: 752 KFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLL----FFPISRFYRVVILFSVTR 807
++DF++ I+ V F + I S L I R R++ R
Sbjct: 1245 N-------IFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIR 1297
Query: 808 NLWKKVLKNAIVIWNLSAFYFLFVFLASLIVL---LYFDGTLDADDMEDTPFGFYSLPNA 864
L ++ + ++N+ FL +F+ ++ + Y + DDM F F + N+
Sbjct: 1298 TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDM----FNFETFGNS 1353
Query: 865 FLTLIKIASTENWTDSLYALQRDSPT----------------LFSALFGSVLLILWFILS 908
+ L +I ++ W L + P + G + + I+S
Sbjct: 1354 MICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIIS 1413
Query: 909 NFVVLNVFVAVIAASFDIEEED 930
VV+N+++AVI +F + E+
Sbjct: 1414 FLVVVNMYIAVILENFSVATEE 1435
>Hs19923117 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2180
Score = 154 bits (390), Expect = 1e-36
Identities = 158/643 (24%), Positives = 282/643 (43%), Gaps = 65/643 (10%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGEL 1228
YF+ VF +FTIE +K A G ++C N +N +DL+V+ I F
Sbjct: 906 YFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI----QSSA 961
Query: 1229 ARIIKAVSALRALRFLTISSMAR--MTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNV 1286
++K + LR LR L + A+ Q +F + I V + F + G+ +
Sbjct: 962 INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQL 1021
Query: 1287 FRGRLGVCNDGD-LSYGEC---YNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMYE 1342
F+G+L C+D + EC Y + + I+ PR++ + ++ +A +++
Sbjct: 1022 FKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFT 1081
Query: 1343 IVSLEGWTDLL-QNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNN 1401
+ + EGW +LL +++ S T P + S IF I++ + F++NIFV F++
Sbjct: 1082 VSTFEGWPELLYRSIDSHTEDKGPIYNYRVEIS-IFFIIYIIIIAFFMMNIFVGFVI--- 1137
Query: 1402 ARMKGTAYLTLAEKSWLEVKRL-LSQVCPDPMPNVFKMNAVRRIC-------YLWAVEKR 1453
+T E+ E K L + + K +RR +W V
Sbjct: 1138 --------VTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYV-VN 1188
Query: 1454 NFYFSVLMQFMLYLHILTLLMSKDQPYGK---LPTNQNIQFMVTTSFLLIQEVMHIYGKS 1510
+ YF LM ++ L+ + L M Q YG+ NI M+ T ++ ++ +
Sbjct: 1189 STYFEYLMFVLILLNTICLAM---QHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1245
Query: 1511 MRLYARKRWNIFRCVVVMFAFATNIYELI--VDHVVVGIS-NARD----------VFQLG 1557
+ Y WN+F ++V+ + I +H S NA + +F++
Sbjct: 1246 PKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVM 1305
Query: 1558 IFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNT--T 1615
+ ++ + + + L+ T S ++ + +LF +YA+ QVFG L T
Sbjct: 1306 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEIN 1365
Query: 1616 GNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGS-----YTDCGSKAFA 1670
N N +T ++++LLFRC+ GE W IM + C E++ S T CGS +FA
Sbjct: 1366 RNNNFQTFPQAVLLLFRCATGEAWQDIML-ACMPGKKCAPESEPSNSTEGETPCGS-SFA 1423
Query: 1671 YALLMSWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDG 1730
+S+ ++ ++ +N+FV++I++ F Y+ S + +FK W E DP+
Sbjct: 1424 VFYFISFYMLCAFLIINLFVAVIMDNFDYL----TRDWSILGPHHLDEFKRIWAEYDPEA 1479
Query: 1731 VGQFDVAYLPKFMHSFDGPLSF-KIWEGRLTVKSLVSKYMKVN 1772
G+ + + PL F K+ R+ K LVS M +N
Sbjct: 1480 KGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLN 1522
Score = 100 bits (248), Expect = 3e-20
Identities = 138/609 (22%), Positives = 250/609 (40%), Gaps = 106/609 (17%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSIL 472
+F R+ + L+LL + +++G+ + + V LR+ R L R L+ ++ GL ++
Sbjct: 934 SFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVL---RPLRAINRAKGLKHVV 990
Query: 473 RALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCG 532
+ + I + N+ + F +GVQ FKG L + +D S Q + + G
Sbjct: 991 QCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL------YTCSDSSK--QTEAECKG 1042
Query: 533 GYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVFV 592
Y+ + +G + + P + + N + FDN++ +M +F
Sbjct: 1043 NYITYK-------------DGEVDHPIIQPRSWE--------NSKFDFDNVLAAMMALFT 1081
Query: 593 IMSANTFTDLMYFTMDTDN----------MAACLFFIVSILCLTVWMVNLLIAVLYSSF- 641
+ + + +L+Y ++D+ + +FFI+ I+ + +M+N+ + + +F
Sbjct: 1082 VSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1141
Query: 642 ---EVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFF 698
E ++ +DK Q + L I K W +E L F
Sbjct: 1142 EQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYK--VWYVVNSTYFEYL--MF 1197
Query: 699 VLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLAKPN 758
VL + +IC LA S + +N + + + VE IL+LI + P + + P
Sbjct: 1198 VLILLNTIC-LAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF--KPKGYFSDPW 1254
Query: 759 YVYDFII---SIICAVLSFN--------SLRISLGQTSAW-LLFFPISRFYRVVILFSVT 806
V+DF+I SII +LS S ++ + S + FF + R R+V L S
Sbjct: 1255 NVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRG 1314
Query: 807 RNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFD---------GTLDADDMEDTPFG 857
+ ++W + ++A LIV+L+F G + +D +
Sbjct: 1315 EGI-------RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRN 1367
Query: 858 --FYSLPNAFLTLIKIASTENWTDSLYALQ--------------RDSPTLFSALFGSVLL 901
F + P A L L + A+ E W D + A + T + F
Sbjct: 1368 NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYF 1427
Query: 902 ILWFILSNFVVLNVFVAVIAASFDIEEEDKRLLQIKHY--LKVTYPE-------RIREFS 952
I +++L F+++N+FVAVI +FD D +L H K + E RI+
Sbjct: 1428 ISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLD 1487
Query: 953 VVPLLERIR 961
VV LL RI+
Sbjct: 1488 VVTLLRRIQ 1496
Score = 71.6 bits (174), Expect = 1e-11
Identities = 67/291 (23%), Positives = 124/291 (42%), Gaps = 64/291 (21%)
Query: 1171 EPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLL------- 1223
E +F+ +FT+E +K IA G ++ PNAY N WN +D ++++ + F+ +L
Sbjct: 134 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVV---VGLFSAILEQATKAD 190
Query: 1224 --------GNGELARIIKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSI 1275
G G + ++A LR LR ++ ++ ++ + + A V F I
Sbjct: 191 GANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVI 250
Query: 1276 LFPYTVWGLNVFRGRLGVCNDGDLSYGECYNE--------------FTNQVFHWDILMPR 1321
+ Y + GL +F G++ + CYN+ + H
Sbjct: 251 II-YAIIGLELFMGKM---------HKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNG 300
Query: 1322 TYADP--------ILHLNSFSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPY 1373
T P I + ++F+ A ++++ +++EGWTD+L M + G P F S
Sbjct: 301 TVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVS-- 358
Query: 1374 SGIFLILFNFLSMVFILNIFVSFIVGNNARMKGTA-----YLTLAEKSWLE 1419
L++F F+LN+ + + G ++ + A + L EK LE
Sbjct: 359 ----LVIF---GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLE 402
Score = 67.8 bits (164), Expect = 2e-10
Identities = 58/275 (21%), Positives = 114/275 (41%), Gaps = 23/275 (8%)
Query: 696 WFFVLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLA 755
W + +F + +AS + + + + N+ + + E +L++ L
Sbjct: 499 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYS--------LG 550
Query: 756 KPNYVYDFIISIICAVLSFNSLRISLGQTSAWL-LFFPISRFYRVVILFSVTR------N 808
Y C V+ L L +T L + R R++ +F +TR N
Sbjct: 551 LQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSN 610
Query: 809 LWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTL 868
L +L + I +L FLF+ + SL+ + F G + D+M+ F + P + LT+
Sbjct: 611 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTV 670
Query: 869 IKIASTENWTDSLY-ALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAVIAASF--- 924
+I + E+W +Y + F + + I+ FI N+++LNVF+A+ +
Sbjct: 671 FQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 730
Query: 925 ----DIEEEDKRLLQIKHYLKVTYPERIREFSVVP 955
++E++ + K + PE+ +E P
Sbjct: 731 ESLTSAQKEEEEEKERKKLARTASPEKKQELVEKP 765
>Hs21914836 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1999
Score = 153 bits (386), Expect = 3e-36
Identities = 214/1081 (19%), Positives = 448/1081 (40%), Gaps = 100/1081 (9%)
Query: 728 NQIVSCILVVETILRLILYCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAW 787
N + + I E L++I P+ + + ++D I LS L ++ + +
Sbjct: 793 NLVFTGIFTAEMFLKII--AMDPYYYFQEGWNIFDGFI----VTLSLVELGLANVEGLSV 846
Query: 788 LLFFPISRFYRVVILFSVTRNLWKKVLKNAI-VIWNLSAFYFLFVFLASLIVLLYFDGT- 845
L F + R +++ + T N+ K++ N++ + NL+ + VF+ +++ + F +
Sbjct: 847 LRSFRLLRVFKLAKSWP-TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 905
Query: 846 ------LDADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSLYALQRDSPTLFSALFGSV 899
+ +D + ++FL + ++ E W ++++ D +
Sbjct: 906 KDCVCKIASDCQLPQRWHMNDFFHSFLIVFRVLCGE-WIETMW----DCMEVAGQAMCLT 960
Query: 900 LLILWFILSNFVVLNVFVAVIAASFDIE-----EEDKRL--LQI---KHYLKVTYPERIR 949
+ ++ ++ N VVLN+F+A++ +SF + ++D + LQI + + V Y +R
Sbjct: 961 VFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKR-- 1018
Query: 950 EFSVVPLLERIRRKFLRKPQI-DDSEDFRQFLFRGTAILSIAQNYEGFNMDLSEDKDHQF 1008
+ E I++ F+RK +I D+ + + + +S G ++D +D +
Sbjct: 1019 -----KIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTTEIGKDLDYLKDVNGTT 1073
Query: 1009 ADRNVKSSFWNRILWRLKALNFYKTNPFFKDPKVVFVQSDDTTPSNRKYTLKLNDWEEEK 1068
+ SS I+ ++F NP + V D N + +D EE K
Sbjct: 1074 SGIGTGSSVEKYIIDESDYMSFIN-NPSLTVTVPIAVGESDFENLNTEDFSSESDLEESK 1132
Query: 1069 LRFLKQHPNFNNTYFIFPPNHALRRFCQRLVPPS--------YGKRTNNRVFFDDTTNKV 1120
+ + + + H Q +V P + + R +
Sbjct: 1133 EKLNESSSSSEGSTV----GHRRPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEE 1188
Query: 1121 GQKRFFYNIEKDIFVFV------TFVATLLMVIYSCYV-TPLYRMNHNKKWNWTTYFEPV 1173
G+ + ++N+ + F V TF+ ++++ +Y Y + V
Sbjct: 1189 GRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKV 1248
Query: 1174 FVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELARIIK 1233
F +F +E L+K +A G+ Y N W +D +++ + A LG EL I K
Sbjct: 1249 FTYIFILEMLLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI-K 1303
Query: 1234 AVSALRALRFLTISSMARMTFKQVMFDGLT----YIFGACAVAFSILFPYTVWGLNVFRG 1289
++ LRALR + +++R +V+ + L I V +++ G+N+F G
Sbjct: 1304 SLRTLRALR--PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
Query: 1290 RLGVC---NDGDLSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMYEIVSL 1346
+ C GD E N T+ + + + + ++ ++ + S+ ++ +
Sbjct: 1362 KFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATF 1421
Query: 1347 EGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNARMK- 1405
+GW D++ + S V + S Y ++ ++F F LN+F+ I+ N + K
Sbjct: 1422 KGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1481
Query: 1406 ----GTAYLTLAEKSWLE-VKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFSVL 1460
++T +K + +K+L S+ P+P N + + + + + F +
Sbjct: 1482 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PGNKFQGMVFDFVTRQ---VFDIS 1536
Query: 1461 MQFMLYLHILTLLMSKDQPYGKLPT---NQNIQFMVTTSFLLIQEVMHIYGKSMRLYARK 1517
+ ++ L+++T+++ D + T N+ F+V + + +++ + Y
Sbjct: 1537 IMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISL----RHYYFTI 1592
Query: 1518 RWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDV--FQLGIFLLVIPQNDTLNELMNT 1575
WNIF VVV+ + +++ V + R + ++G L +I + L+
Sbjct: 1593 GWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFA 1652
Query: 1576 ATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKSLILLFRCSF 1635
SLP++F++ F++ +YAI F K N T S+I LF+ +
Sbjct: 1653 LMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITT 1712
Query: 1636 GEGWNYIMND-LTIEEPFC----YSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMFV 1690
GW+ ++ L + P C + DCG+ + +S+ IIS + VNM++
Sbjct: 1713 SAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYI 1772
Query: 1691 SLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSFDGPL 1750
++I+E FS E P S+++ F W + DPD + L +F + + PL
Sbjct: 1773 AVILENFSVA---TEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPL 1829
Query: 1751 S 1751
+
Sbjct: 1830 N 1830
Score = 90.5 bits (223), Expect = 2e-17
Identities = 113/562 (20%), Positives = 225/562 (39%), Gaps = 86/562 (15%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + ++W L+ L + ++ + Y ++ ++ R+L A R L+ + G+ +
Sbjct: 1267 QTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVV 1326
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFC 531
+ AL IP ++NV + L FW+ F I+GV F G C+ D ++D++
Sbjct: 1327 VNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH-CINTTTGD-----RFDIEDV 1380
Query: 532 GGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVF 591
+ + L + +E A N +++FDN+ +
Sbjct: 1381 NNHTDCLKL-------IERNE-----------------TARWKNVKVNFDNVGFGYLSLL 1416
Query: 592 VIMSANTFTDLMYFTMDTDNMAA----------CLFFIVSILCLTVWMVNLLIAVLYSSF 641
+ + + D+MY +D+ N+ L+F++ I+ + + +NL I V+ +F
Sbjct: 1417 QVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1476
Query: 642 EVVHEKYT-IDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFFV 699
+K+ D F T++ +N +K+L K P +G+ F
Sbjct: 1477 NQQKKKFGGQDIFMTEEQKKYYNAMKKLGS--KKPQKPIPRPGNKFQGMVFDFVTRQVFD 1534
Query: 700 LAIFTSICA-LASMKSHSSDQS---AQDIFSVNQIVSCILVVETILRLI----LYCKTPW 751
++I IC + +M + DQS + +N + + E +L+LI Y W
Sbjct: 1535 ISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGW 1594
Query: 752 KFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLL----FFPISRFYRVVILFSVTR 807
++DF++ I+ V F + I S L I R R++ R
Sbjct: 1595 N-------IFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIR 1647
Query: 808 NLWKKVLKNAIVIWNLSAFYFLFVFLASLIVL---LYFDGTLDADDMEDTPFGFYSLPNA 864
L ++ + ++N+ FL +F+ ++ + Y + DDM F F + N+
Sbjct: 1648 TLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDM----FNFETFGNS 1703
Query: 865 FLTLIKIASTENWTDSLYALQRDSPT----------------LFSALFGSVLLILWFILS 908
+ L +I ++ W L + P + G + + I+S
Sbjct: 1704 MICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIIS 1763
Query: 909 NFVVLNVFVAVIAASFDIEEED 930
VV+N+++AVI +F + E+
Sbjct: 1764 FLVVVNMYIAVILENFSVATEE 1785
Score = 73.6 bits (179), Expect = 3e-12
Identities = 62/249 (24%), Positives = 115/249 (45%), Gaps = 26/249 (10%)
Query: 414 FTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILR 473
F R W L+ T+ + AY D +V LR FR L R LK + + GL +I+
Sbjct: 185 FLRDPWNWLDF--TVITF-AYVTEFVDLGNVSALRTFRVL---RALKTISVIPGLKTIVG 238
Query: 474 ALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPS-DYYQYD----M 528
AL + +L +V + ++ F ++G+Q F G+L+ +C+ + P + S + + + +
Sbjct: 239 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITV 298
Query: 529 QFCGGYLNAETLE-PMKYVFADNSEGPLAKGFL-------------CPANSKCI-SNANP 573
+ G +N E K D+ +GFL CP C+ + NP
Sbjct: 299 NYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358
Query: 574 YNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLL 633
G SFD + +F +M+ + + +L T+ +FF++ I + +++NL+
Sbjct: 359 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418
Query: 634 IAVLYSSFE 642
+AV+ ++E
Sbjct: 419 LAVVAMAYE 427
>Hs7657544 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1980
Score = 151 bits (381), Expect = 1e-35
Identities = 133/615 (21%), Positives = 270/615 (43%), Gaps = 62/615 (10%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGEL 1228
Y + VF +F +E L+K A GF+ + N W +D +++ + A LG EL
Sbjct: 1234 YADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSEL 1289
Query: 1229 ARIIKAVSALRALRFLTISSMARMTFKQVMFDGLT----YIFGACAVAFSILFPYTVWGL 1284
I K++ LRALR + +++R +V+ + L I V +++ G+
Sbjct: 1290 GAI-KSLRTLRALR--PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 1346
Query: 1285 NVFRGRLGVCNDGDLSYGECYNEFTNQVFHWDILMPRTYADPILHLNS------------ 1332
N+F G+ Y C+NE + F + + +T + ++ N+
Sbjct: 1347 NLFAGK----------YHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINF 1396
Query: 1333 --FSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFIL 1390
+ + ++ ++ + +GW D++ + S + + Y I+ ++F F L
Sbjct: 1397 DNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTL 1456
Query: 1391 NIFVSFIVGNNARMKGT-----AYLTLAEKSWLE-VKRLLSQVCPDPMPNVFKMNAVRRI 1444
N+F+ I+ N + K ++T +K + +K+L S+ P+P +N ++ I
Sbjct: 1457 NLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PLNKIQGI 1514
Query: 1445 CYLWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLI---Q 1501
+ + ++ F +++ ++ L+++T+++ D ++ +NI + + F++ +
Sbjct: 1515 VFDFVTQQA---FDIVIMMLICLNMVTMMVETDTQSKQM---ENILYWINLVFVIFFTCE 1568
Query: 1502 EVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDV--FQLGIF 1559
V+ ++ Y WNIF VVV+ + I++ V + R + ++G
Sbjct: 1569 CVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRI 1627
Query: 1560 LLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNIN 1619
L +I + L+ SLP++F++ F++ +++I F K N
Sbjct: 1628 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFN 1687
Query: 1620 CRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEAD----GSYTDCGSKAFAYALLM 1675
T S+I LF+ + GW+ ++ + P C + + G DCG+ + +
Sbjct: 1688 FETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFV 1747
Query: 1676 SWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFD 1735
S+ IIS I VNM++++I+E FS E P S+++ F W + DPD +
Sbjct: 1748 SYIIISFLIVVNMYIAIILENFSVA---TEESADPLSEDDFETFYEIWEKFDPDATQFIE 1804
Query: 1736 VAYLPKFMHSFDGPL 1750
L F + + PL
Sbjct: 1805 YCKLADFADALEHPL 1819
Score = 91.7 bits (226), Expect = 1e-17
Identities = 115/556 (20%), Positives = 224/556 (39%), Gaps = 78/556 (14%)
Query: 414 FTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILR 473
F ++W L+ L + ++ + Y ++ ++ R+L A R L+ + G+ ++
Sbjct: 1259 FFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVN 1318
Query: 474 ALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCGG 533
AL IP ++NV + L FW+ F I+GV F G C FN + D+
Sbjct: 1319 ALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYC--FNETSEIRFEIEDV----- 1370
Query: 534 YLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVFVI 593
N +T E K + +N+E N +I+FDN+ + +
Sbjct: 1371 --NNKT-ECEKLMEGNNTE------------------IRWKNVKINFDNVGAGYLALLQV 1409
Query: 594 MSANTFTDLMYFTMDT----------DNMAACLFFIVSILCLTVWMVNLLIAVLYSSFEV 643
+ + D+MY +D+ DN+ ++F++ I+ + + +NL I V+ +F
Sbjct: 1410 ATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1469
Query: 644 VHEKYT-IDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFFVLA 701
+K+ D F T++ +N +K+L K P +GI + F +
Sbjct: 1470 QKKKFGGQDIFMTEEQKKYYNAMKKLGS--KKPQKPIPRPLNKIQGIVFDFVTQQAFDIV 1527
Query: 702 IFTSICA-LASMKSHSSDQSAQD---IFSVNQIVSCILVVETILRLIL----YCKTPWKF 753
I IC + +M + QS Q ++ +N + E +L++ Y W
Sbjct: 1528 IMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWN- 1586
Query: 754 LAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLL----FFPISRFYRVVILFSVTRNL 809
++DF++ I+ V F + I S L I R R++ R L
Sbjct: 1587 ------IFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTL 1640
Query: 810 WKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTLI 869
++ + ++N+ FL +F+ S+ + F ++D F F + N+ + L
Sbjct: 1641 LFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDM-FNFETFGNSMICLF 1699
Query: 870 KIASTENWTDSLYALQRDSPTLF---------------SALFGSVLLILWFILSNFVVLN 914
+I ++ W L + P + G + + I+S +V+N
Sbjct: 1700 QITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVN 1759
Query: 915 VFVAVIAASFDIEEED 930
+++A+I +F + E+
Sbjct: 1760 MYIAIILENFSVATEE 1775
Score = 72.4 bits (176), Expect = 7e-12
Identities = 61/243 (25%), Positives = 115/243 (47%), Gaps = 30/243 (12%)
Query: 414 FTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILR 473
F R W L+ + A++ +++ + V LR FR L R LK + + GL +I+
Sbjct: 189 FLRDPWNWLDFSVIMMAYITEFVNLGN---VSALRTFRVL---RALKTISVIPGLKTIVG 242
Query: 474 ALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQ-----YDM 528
AL + +L +V + ++ F ++G+Q F G+L+ +CV + N Y + +D
Sbjct: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDW 302
Query: 529 QFCGGYLNAET--------LEPMKYVFADNSEGPLAKGFLCPANSKCI-SNANPYNGRIS 579
+ Y+N +T LEP+ G + CP +C+ + NP G S
Sbjct: 303 E---EYINNKTNFYTVPGMLEPLLC-------GNSSDAGQCPEGYQCMKAGRNPNYGYTS 352
Query: 580 FDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYS 639
FD + +F +M+ + + +L T+ +FF++ I + ++VNL++AV+
Sbjct: 353 FDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAM 412
Query: 640 SFE 642
++E
Sbjct: 413 AYE 415
Score = 66.2 bits (160), Expect = 5e-10
Identities = 75/342 (21%), Positives = 139/342 (39%), Gaps = 61/342 (17%)
Query: 1127 YNIEKDIFVFVTFVATLLMVIYSCYVTPLYRMNHNKKWNWTTYFEPVFVPLFTIEFLVKT 1186
+N+ + I + + + M+I +T M + +W+ E F ++T E LVK
Sbjct: 118 FNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKI 177
Query: 1187 IADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELARIIKAVSALRALRFL-- 1244
IA GF + +PWN +D V++ +I F LGN R + + AL+ + +
Sbjct: 178 IARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFV-NLGNVSALRTFRVLRALKTISVIPG 236
Query: 1245 --TISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRL-GVCNDGDLSY 1301
TI + K++ + +F C F+++ GL +F G L C +++
Sbjct: 237 LKTIVGALIQSVKKLSDVMILTVF--CLSVFALI------GLQLFMGNLRNKCVVWPINF 288
Query: 1302 GECYNEFTNQVFHWDILMPRT--------YADPILHLNS--------------------- 1332
E Y E + F W+ + +P+L NS
Sbjct: 289 NESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNY 348
Query: 1333 -------FSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLS 1385
FS AF +++ +++ + W +L Q + + G Y IF +L F+
Sbjct: 349 GYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG---------KTYM-IFFVLVIFVG 398
Query: 1386 MVFILNIFVSFIVGNNARMKGTAYLTLAEKSWLEVKRLLSQV 1427
+++N+ ++ +V + A L AE+ E K +L Q+
Sbjct: 399 SFYLVNLILA-VVAMAYEEQNQATLEEAEQKEAEFKAMLEQL 439
>7293235 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2131
Score = 150 bits (380), Expect = 2e-35
Identities = 135/605 (22%), Positives = 269/605 (44%), Gaps = 51/605 (8%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGF-IYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGE 1227
Y + +F +F +E L+K +A GF +Y NA+C W +D V+++ I+F A L+G G
Sbjct: 1337 YMDRIFTVIFFLEMLIKWLALGFKVYFTNAWC---W--LDFVIVMVSLINFVASLVGAGG 1391
Query: 1228 LARIIKAVSALRALRFLTISSMARMTFKQVMFDGLTY----IFGACAVAFSILFPYTVWG 1283
+ + K + LRALR + +M+RM +V+ + L IF V + + G
Sbjct: 1392 I-QAFKTMRTLRALR--PLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMG 1448
Query: 1284 LNVFRGRLGVCNDGD---LSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSM 1340
+ +F G+ C D + LS+ N + ++ T+ + ++ + +A+ +
Sbjct: 1449 VQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENY------TWVNSAMNFDHVGNAYLCL 1502
Query: 1341 YEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGN 1400
+++ + +GW ++ + + S V + Y ++ + F F LN+F+ I+ N
Sbjct: 1503 FQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDN 1562
Query: 1401 NARMKGTA------YLTLAEKSWLEVKRLLSQVCP---DPMPNVFKMNAVRRICYLWAVE 1451
K A ++T +K + + + P P P V I +
Sbjct: 1563 FNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEI----VTD 1618
Query: 1452 KRNFYFSVLMQFMLYLHILTLLMSK---DQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYG 1508
K+ F +++ + L++ T+ + + Y + N F+V S + ++ +
Sbjct: 1619 KK---FDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRY 1675
Query: 1509 KSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNAR--DVFQLGIFLLVIPQN 1566
Y + WN+F VVV+ + + I++ V + R V ++G L ++
Sbjct: 1676 H----YFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGA 1731
Query: 1567 DTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKS 1626
+ L+ SLP++F++ F++ ++AI F K N +T +S
Sbjct: 1732 KGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQS 1791
Query: 1627 LILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYT-DCGSKAFAYALLMSWNIISMYIF 1685
+ILLF+ S GW+ +++ + EE + D Y +CGS L+S+ +IS I
Sbjct: 1792 MILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIV 1851
Query: 1686 VNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHS 1745
+NM++++I+E +S E+ + ++ + W++ DP+G L +F+
Sbjct: 1852 INMYIAVILENYS---QATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDV 1908
Query: 1746 FDGPL 1750
+ PL
Sbjct: 1909 LEPPL 1913
Score = 90.5 bits (223), Expect = 2e-17
Identities = 107/554 (19%), Positives = 221/554 (39%), Gaps = 79/554 (14%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + ++W L+ + + + + + S+ + + R+L A R L+ + G+ +
Sbjct: 1360 KVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVV 1419
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFC 531
+ AL IP + NV + L FW+ F I+GVQ F G
Sbjct: 1420 VNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAG------------------------- 1454
Query: 532 GGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCIS-NANPYNGRISFDNIVNSMELV 590
KY ++ G + P + C S N N ++FD++ N+ +
Sbjct: 1455 ------------KYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCL 1502
Query: 591 FVIMSANTFTDLMYFTMDT----------DNMAACLFFIVSILCLTVWMVNLLIAVLYSS 640
F + + + +M +D+ N+ L+F+ I+ + + +NL I V+ +
Sbjct: 1503 FQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDN 1562
Query: 641 FEVVHEKY--TIDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLY----EK 693
F +K +++ F T+D +N +K++ K P W + I +K
Sbjct: 1563 FNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGS--KKPLKAIPRPRWRPQAIVFEIVTDKK 1620
Query: 694 LEWFFVLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLIL----YCKT 749
+ +L I ++ + + +SD + +N I I E +L++ Y
Sbjct: 1621 FDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIE 1680
Query: 750 PWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLL-FFPISRFYRVVILFSVTRN 808
PW V I+SI+ VLS + + T ++ + R R+V R
Sbjct: 1681 PWNLFD----VVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRT 1736
Query: 809 LWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTL 868
L + + ++N+ FL +F+ ++ + +F + + D + F + + + L
Sbjct: 1737 LLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDV-YNFKTFGQSMILL 1795
Query: 869 IKIASTENWTDSLYALQRDSP------------TLFSALFGSVLLILWFILSNFVVLNVF 916
+++++ W L A+ + SA G L+ + ++S +V+N++
Sbjct: 1796 FQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMY 1855
Query: 917 VAVIAASFDIEEED 930
+AVI ++ ED
Sbjct: 1856 IAVILENYSQATED 1869
Score = 67.8 bits (164), Expect = 2e-10
Identities = 59/245 (24%), Positives = 112/245 (45%), Gaps = 20/245 (8%)
Query: 411 PRAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVS 470
P + R +W L+ + A++ G+ D ++ LR FR L R LK V + GL +
Sbjct: 206 PFTYLRDAWNWLDFVVIALAYVTMGI---DLGNLAALRTFRVL---RALKTVAIVPGLKT 259
Query: 471 ILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPS------DYY 524
I+ A+ + L +V + ++ F ++G+Q + G L ++C+ P D S + +
Sbjct: 260 IVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENW 319
Query: 525 QYDMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISN--ANPYNGRISFDN 582
Y + + + + E + + N G C + C+ NP G SFD+
Sbjct: 320 DYHNRNSSNWYSED--EGISFPLCGNISG----AGQCDDDYVCLQGFGPNPNYGYTSFDS 373
Query: 583 IVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSFE 642
+ F +M+ + + DL + LFFIV I + ++VNL++A++ S++
Sbjct: 374 FGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYD 433
Query: 643 VVHEK 647
+ +K
Sbjct: 434 ELQKK 438
>CE28820 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1783
Score = 150 bits (378), Expect = 3e-35
Identities = 143/624 (22%), Positives = 273/624 (42%), Gaps = 36/624 (5%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGEL 1228
YF+ F +FT+E +K I G ++ ++C N +N +D++V +A+ + F +
Sbjct: 833 YFDYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILV-VAVSLTSFVLRTDAMSV 891
Query: 1229 ARIIKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFR 1288
+I++ + LR LR + + + + V+ T I V F + F + + G+ +F+
Sbjct: 892 VKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKT-IGNIMLVTFMLQFMFAIIGVQLFK 950
Query: 1289 GRLGVCND-GDLSYGECYNEFTNQVFHWD-------ILMPRTYADPILHLNSFSSAFRSM 1340
G +CND ++ EC E+ H++ + R +++ + ++ A S+
Sbjct: 951 GTFFLCNDLSKMTEAECRGEY----IHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISL 1006
Query: 1341 YEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGN 1400
+ + + EGW LL + S + +F I F + F++NIFV F++
Sbjct: 1007 FVVSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALFFIAFIIVIAFFMMNIFVGFVIVT 1066
Query: 1401 NARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFSVL 1460
+ +G E + K + + P N ++ + W V R F + +
Sbjct: 1067 -FQNEGEREYENCELDKNQRKCIEFALKAKPHRRYIPRNRLQYRVW-WFVTSRAFEYVI- 1123
Query: 1461 MQFMLYLHILTLLMSKDQPYGK-LPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARKRW 1519
F++ + L K P + ++ ++ T + V+ I + + Y RW
Sbjct: 1124 --FLIIVMNTVSLACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIVALNPKNYISDRW 1181
Query: 1520 NIFRCVVVMFAFATNIYELIVDHVVVGIS-NARDVFQLGIFLLVIPQNDTLNELMNTATA 1578
N+F +VV+ +F Y + IS N +F++ + ++ + + + L+ T
Sbjct: 1182 NVFDLLVVVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMK 1241
Query: 1579 SLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTT--GNINCRTVTKSLILLFRCSFG 1636
S ++ + +LF +YA+ Q FG L +T+ N N + ++++LFR + G
Sbjct: 1242 SFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAILVLFRSATG 1301
Query: 1637 EGWNYIMNDLTIEEPFCYSEADGSY-------TDCGSKAFAYALLMSWNIISMYIFVNMF 1689
E W IM + E Y + CG+ FAY +S+ ++ ++ +N+F
Sbjct: 1302 EAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNN-FAYPYFISFFMLCSFLVINLF 1360
Query: 1690 VSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSFDGP 1749
V++I++ F Y+ R+ + P EE F W E DPD G+ + + P
Sbjct: 1361 VAVIMDNFDYL-TRDWSILGPHHLEE---FVRLWSEYDPDAKGRIKHLDVVTLLRKISPP 1416
Query: 1750 LSF-KIWEGRLTVKSLVSKYMKVN 1772
L F K+ RL K LVS M +N
Sbjct: 1417 LGFGKLCPHRLACKRLVSMNMPLN 1440
Score = 120 bits (300), Expect = 3e-26
Identities = 141/641 (21%), Positives = 258/641 (39%), Gaps = 113/641 (17%)
Query: 1143 LLMVIYSCYVTPLYR----MNHNKKWNWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAY 1198
L M+ +C +Y+ + + K E VF+ +FTIE ++K +A GF++ P+AY
Sbjct: 95 LFMICANCIALAIYQPYPAQDSDYKNTLLETIEYVFIVVFTIECVLKIVAMGFMFHPSAY 154
Query: 1199 CLNPWNRID-LVVLIALWIDFFAWLLGNGELARIIKAVSALRALRFLTISSMARMTFKQV 1257
N WN +D ++V+I L + + G + ++A LR LR ++ ++ +
Sbjct: 155 LRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVLRPLRLVSGVPSLQVVLNAI 214
Query: 1258 MFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRL--------------------GVCNDG 1297
+ + + A V F IL Y + GL +F G+L G +G
Sbjct: 215 LRAMIPLLHIALLVLFVILI-YAIIGLELFCGKLHSTCIDPATGQLAQKDPTPCGTDTEG 273
Query: 1298 DLSYGECYNEFTNQVFHWDILMPRTYADP---ILHLNSFSSAFRSMYEIVSLEGWTDLLQ 1354
+ + TN W+ T+ P I + ++F A ++++ VSLEGWTD++
Sbjct: 274 SAFKCQPSDSLTNMGVRWECSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMY 333
Query: 1355 NMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVG------NNARMKG-- 1406
+ + G P I+ + L F+LN+ + + G AR +G
Sbjct: 334 WVNDAVGREWP---------WIYFVTLVILGSFFVLNLVLGVLSGEFSKEREKARARGLF 384
Query: 1407 --------------------------------------TAYLTLAEKSWLEVKRLLSQVC 1428
A + E++ E + + V
Sbjct: 385 QKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPVAQTVVGEEADEEGEERVEDVR 444
Query: 1429 PDP----MPNVFKMNAVRRICYLWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLP 1484
P M + K+N R V+ + FY+ V++ +L +LT + YG+
Sbjct: 445 PSKWAARMKRLEKLNRRCRRACRRLVKSQTFYWLVILLVLLNTLVLT-----SEHYGQSE 499
Query: 1485 TNQNIQFMVTTSFLLI---QEVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVD 1541
+ Q M F+++ + ++ +Y Y ++N F C VV+ + +
Sbjct: 500 WLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILEFVLVYFDL 559
Query: 1542 HVVVGISNARDVFQLGIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIAL 1601
+G+S R L IF V +L L+++ SL SI SL+ F+ +++A+
Sbjct: 560 MKPLGVSVLRSARLLRIF-KVTKYWTSLRNLVSSLLNSLRSIISLLLLLFLFIVIFALLG 618
Query: 1602 NQVFG----VTKLGPNTTGNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEA 1657
QVFG P N + T ++L+ +F+ GE WN +M + E+
Sbjct: 619 MQVFGGKFNFNPQQPKPRANFD--TFVQALLTVFQILTGEDWNTVM--------YHGIES 668
Query: 1658 DGSYTDCGSKAFAYALLMSWNIISMYIFVNMFVSLIVEKFS 1698
G G Y +++ I YI +N+F+++ V+ +
Sbjct: 669 FGGVGTLGVIVCIYYIVLF--ICGNYILLNVFLAIAVDNLA 707
Score = 104 bits (260), Expect = 1e-21
Identities = 130/601 (21%), Positives = 252/601 (41%), Gaps = 101/601 (16%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSIL 472
+F R+++ L++L + ++ L D + +++ R L R L+ ++ GL ++
Sbjct: 861 SFCRNAFNLLDILVVAVSLTSFVLRT---DAMSVVKILRVLRVLRPLRAINRAKGLKHVV 917
Query: 473 RALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCG 532
+ + + + N+ + F I+GVQ FKG+ +F ND S + + + G
Sbjct: 918 QCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGT------FFLCNDLSKMTEAECR--G 969
Query: 533 GYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVFV 592
Y++ E +P K P + K + + N +N FDN+ ++M +FV
Sbjct: 970 EYIHYEDGDPTK-----------------PVSKKRVWSNNDFN----FDNVGDAMISLFV 1008
Query: 593 IMSANTFTDLMYFTMDTD----------NMAACLFFIVSILCLTVWMVNLLIAVLYSSF- 641
+ + + L+Y +D++ A LFFI I+ + +M+N+ + + +F
Sbjct: 1009 VSTFEGWPQLLYVAIDSNEEDKGPIHNSRQAVALFFIAFIIVIAFFMMNIFVGFVIVTFQ 1068
Query: 642 ---EVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFF 698
E +E +DK Q + F +K H + + W R +E + F
Sbjct: 1069 NEGEREYENCELDK--NQRKCIEFALKAKPHRRYIPRNRLQYRVWWFVTSRAFEYV--IF 1124
Query: 699 VLAIFTSICALASMKSHSSDQSAQDIFSV-NQIVSCILVVETILRLILYCKTPWKFLAKP 757
++ + ++ + K + S + +D V N I + + E +L+++ P +++
Sbjct: 1125 LIIVMNTVS--LACKHYPSSRGFEDFLDVFNLIFTGVFAFEAVLKIV--ALNPKNYISDR 1180
Query: 758 NYVYDFIISIICAVLSFNSLRISLGQTSAWLL-FFPISRFYRVVILFSVTRNLWKKVLKN 816
V+D ++ ++ + + +++ G T+ + FF + R R+V L S +
Sbjct: 1181 WNVFDLLV-VVGSFIDITYGKLNPGGTNLISINFFRLFRVMRLVKLLSRGEGI------- 1232
Query: 817 AIVIWNLSAFYFLFVFLASLIVLLY---------FDGTLDADDMED--TPFGFYSLPNAF 865
++W + ++A LIVLL+ F G + DD F+S P A
Sbjct: 1233 RTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKVALDDSTSIHRNNNFHSFPAAI 1292
Query: 866 LTLIKIASTENWTDSLYALQRDSPTLFSAL-----------------FGSVLLILWFILS 908
L L + A+ E W D + + + F I +F+L
Sbjct: 1293 LVLFRSATGEAWQDIMLSCSDREDVRCDPMSDDYHKGGLNESRCGNNFAYPYFISFFMLC 1352
Query: 909 NFVVLNVFVAVIAASFDIEEEDKRLLQIKHYLKVTY------PE---RIREFSVVPLLER 959
+F+V+N+FVAVI +FD D +L H + P+ RI+ VV LL +
Sbjct: 1353 SFLVINLFVAVIMDNFDYLTRDWSILGPHHLEEFVRLWSEYDPDAKGRIKHLDVVTLLRK 1412
Query: 960 I 960
I
Sbjct: 1413 I 1413
Score = 90.9 bits (224), Expect = 2e-17
Identities = 135/586 (23%), Positives = 235/586 (40%), Gaps = 112/586 (19%)
Query: 411 PRAFTRSSWGRLELLSTISAWLAYGLSINDYD--DVHGLRLFRSLMAFRILKLVDLDSGL 468
P A+ R++W L+ + + ++ LS DV LR FR L R L+LV L
Sbjct: 151 PSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDVKALRAFRVL---RPLRLVSGVPSL 207
Query: 469 VSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPS--DYYQY 526
+L A+ + LL++ ++L+ + + I+G++ F G L C+ DP+ Q
Sbjct: 208 QVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTCI-----DPATGQLAQK 262
Query: 527 DMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLC-PANS--------KCISNA---NPY 574
D CG ++EG F C P++S +C SN P
Sbjct: 263 DPTPCG----------------TDTEG---SAFKCQPSDSLTNMGVRWECSSNTTWPGPN 303
Query: 575 NGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMA-ACLFFIVSILCLTVWMVNLL 633
NG +FDN +M VF +S +TD+MY+ D ++F+ ++ + +++NL+
Sbjct: 304 NGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPWIYFVTLVILGSFFVLNLV 363
Query: 634 IAVLYSSFEVVHEKY----TIDKFSTQD-------NYLVFNVKR---------------L 667
+ VL F EK KF + YL + + +
Sbjct: 364 LGVLSGEFSKEREKARARGLFQKFREKQQLEEDLKGYLDWITQAEDIEPVNEDEQEDEPV 423
Query: 668 AHLI---------KSKSDTTKSPAWAERGIRLYEKLE-----------------WFFVLA 701
A + + + + + WA R RL EKL W +L
Sbjct: 424 AQTVVGEEADEEGEERVEDVRPSKWAARMKRL-EKLNRRCRRACRRLVKSQTFYWLVILL 482
Query: 702 IFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLAKPNYVY 761
+ + L S H D F + +++ + L +Y + +
Sbjct: 483 VLLNTLVLTS--EHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRF 540
Query: 762 D---FIISIICAVLSFNSLRISLGQT---SAWLLFFPISRFYRVVILFSVTRNLWKKVLK 815
D I SI+ VL + L LG + SA LL R ++V ++ RNL +L
Sbjct: 541 DCFVVISSILEFVLVYFDLMKPLGVSVLRSARLL-----RIFKVTKYWTSLRNLVSSLLN 595
Query: 816 NAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTP-FGFYSLPNAFLTLIKIAST 874
+ I +L FLF+ + +L+ + F G + + + P F + A LT+ +I +
Sbjct: 596 SLRSIISLLLLLFLFIVIFALLGMQVFGGKFNFNPQQPKPRANFDTFVQALLTVFQILTG 655
Query: 875 ENWTDSLY-ALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAV 919
E+W +Y ++ + + I+ FI N+++LNVF+A+
Sbjct: 656 EDWNTVMYHGIESFGGVGTLGVIVCIYYIVLFICGNYILLNVFLAI 701
>Hs5730033 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1956
Score = 147 bits (370), Expect = 2e-34
Identities = 137/619 (22%), Positives = 267/619 (43%), Gaps = 68/619 (10%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGEL 1228
Y + VF +F E L+K +A GF Y N W +D +++ I A +L E+
Sbjct: 1188 YTDRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWLDFLIVNISLISLTAKILEYSEV 1243
Query: 1229 ARIIKAVSALRALRFLTISSMARMTFKQVMFDGLT----YIFGACAVAFSILFPYTVWGL 1284
A I KA+ LRALR + +++R +V+ D L I V +++ G+
Sbjct: 1244 API-KALRTLRALR--PLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGV 1300
Query: 1285 NVFRGRLGVC---NDGDLSY---------GECYNEFTNQVFHWDILMPRTYADPILHLNS 1332
N+F G+ C DG+ S +C + + F W + ++ ++
Sbjct: 1301 NLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFW--------VNVKVNFDN 1352
Query: 1333 FSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNI 1392
+ + ++ ++ + +GW D++ + S V + + Y ++ ++F F LN+
Sbjct: 1353 VAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNL 1412
Query: 1393 FVSFIVGNNARMKGTA-----YLTLAEKSWLE-VKRLLSQVCPDPMPNVFKMNAVRRICY 1446
FV I+ N + K ++T +K + +K+L S+ P+P +N + +
Sbjct: 1413 FVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PLNKFQGFVF 1470
Query: 1447 LWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQP-------YGKLPTNQNIQFMVTTSFLL 1499
+ F + + ++ L+++T+++ D GK+ NQ + T ++
Sbjct: 1471 DIVTRQA---FDITIMVLICLNMITMMVETDDQSEEKTKILGKI--NQFFVAVFTGECVM 1525
Query: 1500 IQEVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGIS----NARDVFQ 1555
+ Y Y WN+F +VV+ + A+ I+ I+ + S + +
Sbjct: 1526 KMFALRQY------YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLAR 1579
Query: 1556 LGIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTT 1615
+G L +I + L+ SLP++F++ F++ +Y+I F +
Sbjct: 1580 IGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGID 1639
Query: 1616 GNINCRTVTKSLILLFRCSFGEGWNYIMND-LTIEEPFC---YSEADGSYTDCGSKAFAY 1671
N +T S++ LF+ + GW+ +++ L P+C ++G+ DCGS A
Sbjct: 1640 DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGI 1699
Query: 1672 ALLMSWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGV 1731
++ IIS I VNM++++I+E F+ E P S+++ F W + DP+
Sbjct: 1700 IFFTTYIIISFLIVVNMYIAVILENFNVA---TEESTEPLSEDDFDMFYETWEKFDPEAT 1756
Query: 1732 GQFDVAYLPKFMHSFDGPL 1750
+ L F + GPL
Sbjct: 1757 QFITFSALSDFADTLSGPL 1775
Score = 104 bits (259), Expect = 2e-21
Identities = 119/564 (21%), Positives = 232/564 (41%), Gaps = 88/564 (15%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + ++W L+ L + ++ I +Y +V ++ R+L A R L+ + G+ +
Sbjct: 1211 KKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVV 1270
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFC 531
+ AL IP ++NV + L FW+ F I+GV F G R C
Sbjct: 1271 VDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWR--------------------C 1310
Query: 532 GGYLNAE-TLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPY---NGRISFDNIVNSM 587
Y + E +L P+ V N++ ++ K ++ + N +++FDN+
Sbjct: 1311 INYTDGEFSLVPLSIV---NNK----------SDCKIQNSTGSFFWVNVKVNFDNVAMGY 1357
Query: 588 ELVFVIMSANTFTDLMYFTMDT----------DNMAACLFFIVSILCLTVWMVNLLIAVL 637
+ + + + D+MY +D+ DN+ L+F++ I+ + +NL + V+
Sbjct: 1358 LALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVI 1417
Query: 638 YSSFEVVHEKYT-IDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLYEKLE 695
+F +K D F T++ +N +K+L K P +G
Sbjct: 1418 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGS--KKPQKPIPRPLNKFQGFVFDIVTR 1475
Query: 696 WFFVLAIFTSICA-LASMKSHSSDQSAQD---IFSVNQIVSCILVVETILRLIL----YC 747
F + I IC + +M + DQS + + +NQ + E ++++ Y
Sbjct: 1476 QAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYF 1535
Query: 748 KTPWKFLAKPNYVYDFIISIIC-AVLSFNSLRISLGQTSAWLLF-----FPISRFYRVVI 801
W V+DFI+ ++ A L F+++ SL + LF I R R++
Sbjct: 1536 TNGWN-------VFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIR 1588
Query: 802 LFSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSL 861
R L ++ + ++N+ FL +F+ S+ + F ++D F F +
Sbjct: 1589 AAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDM-FNFQTF 1647
Query: 862 PNAFLTLIKIASTENWTDSLYALQRDSPTLF---------------SALFGSVLLILWFI 906
N+ L L +I ++ W L + P S G + + I
Sbjct: 1648 ANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYII 1707
Query: 907 LSNFVVLNVFVAVIAASFDIEEED 930
+S +V+N+++AVI +F++ E+
Sbjct: 1708 ISFLIVVNMYIAVILENFNVATEE 1731
Score = 75.1 bits (183), Expect = 1e-12
Identities = 64/238 (26%), Positives = 113/238 (46%), Gaps = 15/238 (6%)
Query: 414 FTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILR 473
+ R W L+ S I+ LAY + D + GLR FR L R LK V + GL I+
Sbjct: 184 YLRDPWNWLDF-SVIT--LAYVGTAIDLRGISGLRTFRVL---RALKTVSVIPGLKVIVG 237
Query: 474 ALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVW--FNPNDPSDYYQYDMQFC 531
AL + + +L +V + ++ F ++G+Q FKG+LK +CV N+ ++Y +
Sbjct: 238 ALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDI 297
Query: 532 GGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVF 591
Y+N + G G++C S NP SFD+ + +F
Sbjct: 298 --YINKRGTSDPLLCGNGSDSGHCPDGYICLKTSD-----NPDFNYTSFDSFAWAFLSLF 350
Query: 592 VIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSFEVVHEKYT 649
+M+ +++ L T+ T +FF++ I + ++VNL++AV+ ++E ++ T
Sbjct: 351 RLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATT 408
Score = 55.8 bits (133), Expect = 7e-07
Identities = 63/264 (23%), Positives = 112/264 (41%), Gaps = 61/264 (23%)
Query: 1171 EPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELAR 1230
E VF ++T E L+K +A GF Y +PWN W+DF L A
Sbjct: 157 EYVFTVIYTFEALIKILARGFCLNEFTYLRDPWN----------WLDFSVITLAYVGTAI 206
Query: 1231 IIKAVSALRALRFL-TISSMARMTFKQVMFDGLTYIFGACA-VAFSILFPYTVW---GLN 1285
++ +S LR R L + +++ + +V+ L + A V +F +V+ GL
Sbjct: 207 DLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQ 266
Query: 1286 VFRGRL-GVCNDGDLSYGECYNEFTNQVFHW--DI-LMPRTYADPIL------------- 1328
+F+G L C D++ NE TN H DI + R +DP+L
Sbjct: 267 LFKGNLKNKCVKNDMA----VNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDG 322
Query: 1329 ---------------HLNSFSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPY 1373
+SF+ AF S++ +++ + W L Q + ++G +++
Sbjct: 323 YICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSG-----KIYM--- 374
Query: 1374 SGIFLILFNFLSMVFILNIFVSFI 1397
IF +L FL +++N+ ++ +
Sbjct: 375 --IFFVLVIFLGSFYLVNLILAVV 396
Score = 53.1 bits (126), Expect = 4e-06
Identities = 77/334 (23%), Positives = 134/334 (40%), Gaps = 50/334 (14%)
Query: 1416 SWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFSVL------MQFMLYLHI 1469
S LE Q CP + ++ + + C +W V+ + F ++ + L + +
Sbjct: 619 SVLEELEESEQKCPPCLTSLSQKYLIWDCCPMW-VKLKTILFGLVTDPFAELTITLCIVV 677
Query: 1470 LTLLMSKDQPYGKLPTNQ---NIQFMVTTSFLLIQEVMHIYGKSMRLYARKRWNIFRCVV 1526
T+ M+ + +G PT + I +V T F + V I Y +K+WNIF C++
Sbjct: 678 NTIFMAMEH-HGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCII 736
Query: 1527 VMFAFATNIYELIVDHVVVGISNARDVFQLGIFLLVIPQNDTLNELMNTATASLPSIFSL 1586
V ++ EL V +S R L +F L TLN L+ S+ ++ +L
Sbjct: 737 V----TVSLLELGVAK-KGSLSVLRSFRLLRVFKLA-KSWPTLNTLIKIIGNSVGALGNL 790
Query: 1587 VYTWFILFLVYAIALNQVFGVTKLGPNTTGNINC----------RTVTKSLILLFRCSFG 1636
I+ V+A+ Q+ G N NI+ S +++FR G
Sbjct: 791 TIILAIIVFVFALVGKQLLGENY--RNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCG 848
Query: 1637 EGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMFVSLIVEK 1696
E W IE + E G K+ L ++ ++ + +N+F++L++
Sbjct: 849 E-W--------IENMWACMEV-------GQKSICLILFLTVMVLGNLVVLNLFIALLLNS 892
Query: 1697 FSYVYHREENKHSPASQEEVRKFKVAWREIDPDG 1730
FS +N +P EV +VA I G
Sbjct: 893 FS-----ADNLTAPEDDGEVNNLQVALARIQVFG 921
>Hs4502523 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2339
Score = 145 bits (365), Expect = 8e-34
Identities = 165/711 (23%), Positives = 299/711 (41%), Gaps = 67/711 (9%)
Query: 1080 NTYFIFPPNHALRRFCQRLVPPSYGKRTNNRVFFDDTTNKVGQKRFFYNIEKDIFVFVTF 1139
++ F P + LRRFC +V Y F V
Sbjct: 1128 SSMFCLSPTNLLRRFCHYIVTMRY------------------------------FEVVIL 1157
Query: 1140 VATLLMVIYSCYVTPLYRMNHNKKWNWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYC 1199
V L I P+ + + N Y + +F +FT E ++K I G + P AY
Sbjct: 1158 VVIALSSIALAAEDPV--RTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYF 1215
Query: 1200 LNPWNRIDLVVLIALWIDFFAWLLGNGELARIIKAVSALRALRFLTISSMARMTFKQVMF 1259
+ WN +D +V+ + FA+ G+ IK++ LR LR + ++ R+ + +F
Sbjct: 1216 RDLWNILDFIVVSGALV-AFAFSGSKGKDINTIKSLRVLRVLR--PLKTIKRLPKLKAVF 1272
Query: 1260 D----GLTYIFGACAVAFSILFPYTVWGLNVFRGRLGVCNDGDLSY-GECYNEFTNQVFH 1314
D L + V +F + V + +F+G+ C D +C ++ +
Sbjct: 1273 DCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKE 1332
Query: 1315 WDILMPRTYADPILHLNSFSSAFRSMYEIVSLEGWTDLLQNMMSST----GVGTPAELFA 1370
PR + H ++ A +++ + + EGW +L++ + +T G +
Sbjct: 1333 EVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMEL 1392
Query: 1371 SPYSGIFLILFNFLSMVFILNIFVSFIVGNNARMKGTAYLTLAEKSWLEVKRLLSQVCPD 1430
S + ++ ++F F F +NIFV+ I+ + +G ++ E + +
Sbjct: 1393 SIFYVVYFVVFPF----FFVNIFVALII-ITFQEQGDKVMSECSLEKNERACIDFAISAK 1447
Query: 1431 PMPNVFKMNAVRRICYLWA-VEKRNFYFSVLMQFMLYLHILTLLMS-KDQPYGKLPTNQN 1488
P+ N W V F + ++ M+ L+ + L+M D PY +
Sbjct: 1448 PLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMA--MIALNTVVLMMKFYDAPY-EYELMLK 1504
Query: 1489 IQFMVTTSFLLIQEVMHIYGKSMRLYARKRWNIFRCVVVMFAFA-TNIYELIVDHVVVGI 1547
+V TS ++ V+ I + Y R WN+F V V+ + + E+ + + +
Sbjct: 1505 CLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINL 1564
Query: 1548 SNARDVFQLGIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGV 1607
S R +F+ + ++ Q T+ L+ T S ++ + +LF +YAI QVFG
Sbjct: 1565 SFLR-LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1623
Query: 1608 TKLGPNTTGN--INCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCG 1665
L +T+ N N RT ++L+LLFR + GE W+ IM + C +A+ T+CG
Sbjct: 1624 IALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLS-CLSNQACDEQANA--TECG 1680
Query: 1666 SKAFAYALLMSWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWRE 1725
S FAY +S+ + ++ +N+FV++I++ F Y+ R+ + P +E F W E
Sbjct: 1681 SD-FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYL-TRDSSILGPHHLDE---FIRVWAE 1735
Query: 1726 IDPDGVGQFDVAYLPKFMHSFDGPLSF-KIWEGRLTVKSLVSKYMKVNPND 1775
DP G+ + + + PL K R+ K LV M ++ D
Sbjct: 1736 YDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNED 1786
Score = 98.6 bits (244), Expect = 9e-20
Identities = 135/583 (23%), Positives = 241/583 (41%), Gaps = 111/583 (19%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSIL 472
++ R+ W ++ + ++ LA + D+D LR R++ R LKLV L +L
Sbjct: 160 SYLRNGWNVMDFVVVLTGILA--TAGTDFD----LRTLRAVRVLRPLKLVSGIPSLQVVL 213
Query: 473 RALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCG 532
+++ + LL +G +L + + F I+G++ + G + C
Sbjct: 214 KSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKAC-------------------- 253
Query: 533 GYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISN-ANPYNGRISFDNIVNSMELVF 591
+ N+ EP+ D G A LC +++C P G +FDNI+ ++ VF
Sbjct: 254 -FPNSTDAEPV----GDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
Query: 592 VIMSANTFTDLMYFTMD-TDNMAACLFFIVSILCLTVWMVNLLIAVLYSSF----EVVHE 646
++ +TD++Y T D N L+FI I+ + +M+NL++ VL F E V
Sbjct: 309 QCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVEN 368
Query: 647 KYTIDKFSTQ-------DNYL--VFNVKRLAHLIKSKSDTTKSP------AWAERG---- 687
+ K Q + YL +F + + + ++ KSP A ++
Sbjct: 369 RRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDL 428
Query: 688 IRLYEKLEWFFVLAIFTSICALASMKSHSSDQSA-----QDIF-----------SVNQIV 731
I E + F L S A AS+KS ++ S+ + +F S +V
Sbjct: 429 IHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVV 488
Query: 732 SCILVVETILRLILYCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRI-SLGQTS----- 785
C++ + T+ +++ P + L Y +F+ + L+ SL++ LG S
Sbjct: 489 LCVVALNTLCVAMVHYNQP-RRLTTTLYFAEFV--FLGLFLTEMSLKMYGLGPRSYFRSS 545
Query: 786 ----------------AWLLFFPISRF-------YRVVILFSVT------RNLWKKVLKN 816
W P S F R++ +F VT RNL +L +
Sbjct: 546 FNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNS 605
Query: 817 AIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTLIKIASTEN 876
I +L FLF+ + +L+ + F G + D E F + P A LT+ +I + E+
Sbjct: 606 MKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQD-ETPTTNFDTFPAAILTVFQILTGED 664
Query: 877 WTDSLYALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAV 919
W +Y + +F S I+ + N+ +LNVF+A+
Sbjct: 665 WNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAI 707
Score = 63.9 bits (154), Expect = 2e-09
Identities = 53/242 (21%), Positives = 106/242 (42%), Gaps = 23/242 (9%)
Query: 1171 EPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELAR 1230
EP F+ +F E +K IA GF++ +Y N WN +D VV++ G R
Sbjct: 134 EPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLT----GILATAGTDFDLR 189
Query: 1231 IIKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGR 1290
++AV LR L+ ++ ++ K +M + + + F+IL + + GL + G+
Sbjct: 190 TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILM-FAIIGLEFYMGK 248
Query: 1291 LGVCNDGDLSYGE------CYNEFTNQVFHWDILMPRTYADPILHLNSFSS---AFRSMY 1341
+ + E C E ++ D + P + +F + A +++
Sbjct: 249 FHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVF 308
Query: 1342 EIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNN 1401
+ +++EGWTD+L N + G + ++ ++ I + F+LN+ + + G
Sbjct: 309 QCITMEGWTDILYNTNDAAG---------NTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF 359
Query: 1402 AR 1403
A+
Sbjct: 360 AK 361
Score = 60.8 bits (146), Expect = 2e-08
Identities = 66/291 (22%), Positives = 122/291 (41%), Gaps = 17/291 (5%)
Query: 1450 VEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGK 1509
V+ ++FY+ VL ++ L+ L + M +L T V L + + +YG
Sbjct: 479 VKAQSFYWVVLC--VVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGL 536
Query: 1510 SMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLLVIPQNDTL 1569
R Y R +N F V++ + ++ I GIS R + L IF V +L
Sbjct: 537 GPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFK-VTKYWSSL 595
Query: 1570 NELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKSLIL 1629
L+ + S+ SI SL++ F+ +V+A+ Q+FG + T N T +++
Sbjct: 596 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILT 655
Query: 1630 LFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMF 1689
+F+ GE WN +M + E+ G + +F + +L + Y +N+F
Sbjct: 656 VFQILTGEDWNAVM--------YHGIESQGGVSKGMFSSFYFIVL---TLFGNYTLLNVF 704
Query: 1690 VSLIVEKFSYVYH---REENKHSPASQEEVRKFKVAWREIDPDGVGQFDVA 1737
+++ V+ + EE A+Q+ + E+ P +A
Sbjct: 705 LAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIA 755
>Hs4502527 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2181
Score = 142 bits (357), Expect = 7e-33
Identities = 150/677 (22%), Positives = 274/677 (40%), Gaps = 63/677 (9%)
Query: 1135 VFVTFVATLLMVIYSCYVTPLYRMNHNKKWNWTTYFEPVFVPLFTIEFLVKTIADGFIYT 1194
+F + +M+ + +H+ + YF+ F +FT+E L+K G
Sbjct: 907 IFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLH 966
Query: 1195 PNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELARIIKAVSALRALRFLTISSMAR--M 1252
A+C N +N +D++V+ + F ++K + LR LR L + A+
Sbjct: 967 KGAFCRNYFNLLDMLVVGVSLVSFGI----QSSAISVVKILRVLRVLRPLRAINRAKGLK 1022
Query: 1253 TFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRLGVCNDGDLSY-GECYNEFTNQ 1311
Q +F + I V + F + G+ +F+G+ C D S EC F
Sbjct: 1023 HVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLF--- 1079
Query: 1312 VFHWD------ILMPRTYADPILHLNSFSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTP 1365
+ + D ++ R + + + ++ SA +++ + + EGW LL + S G
Sbjct: 1080 ILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIG 1139
Query: 1366 AELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNARMKGTAYLTLAEKSWLEVKRL-L 1424
IF I++ + F++NIFV F++ +T E+ E K L
Sbjct: 1140 PIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVI-----------VTFQEQGEKEYKNCEL 1188
Query: 1425 SQVCPDPMPNVFKMNAVRRICYLWAVEKRNFY------FSVLMQFMLYLHILTLLMSKDQ 1478
+ + K +RR + + +Y F +M ++ L+ L L M +
Sbjct: 1189 DKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYE 1248
Query: 1479 PYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARKRWNIFRCVVVM---------F 1529
+I MV T ++ V+ + + Y WN F ++V+
Sbjct: 1249 QSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSE 1308
Query: 1530 AFATNIYELIVDHVVVGISNARDVFQLGIFLL--------VIPQNDTLNELMNTATASLP 1581
A T + V G S + + F L ++ + + + L+ T S
Sbjct: 1309 ADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQ 1368
Query: 1582 SIFSLVYTWFILFLVYAIALNQVFGVTKLGPNT--TGNINCRTVTKSLILLFRCSFGEGW 1639
++ + +LF +YA+ Q+FG + N N N +T ++++LLFRC+ GE W
Sbjct: 1369 ALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAW 1428
Query: 1640 NYIMNDLTIEEPFCYSEAD---GSYTDCGSKAFAYALLMSWNIISMYIFVNMFVSLIVEK 1696
IM + C E+D G CGS FA +S+ ++ ++ +N+FV++I++
Sbjct: 1429 QEIML-ACLPGKLCDPESDYNPGEEYTCGSN-FAIVYFISFYMLCAFLIINLFVAVIMDN 1486
Query: 1697 FSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSFDGPLSF-KIW 1755
F Y+ S + +FK W E DP+ G+ + + PL F K+
Sbjct: 1487 FDYL----TRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLC 1542
Query: 1756 EGRLTVKSLVSKYMKVN 1772
R+ K LV+ M +N
Sbjct: 1543 PHRVACKRLVAMNMPLN 1559
Score = 79.7 bits (195), Expect = 4e-14
Identities = 131/619 (21%), Positives = 240/619 (38%), Gaps = 124/619 (20%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSIL 472
AF R+ + L++L + +++G+ + V LR+ R L R L+ ++ GL ++
Sbjct: 969 AFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVL---RPLRAINRAKGLKHVV 1025
Query: 473 RALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCG 532
+ + I + N+ + F +GVQ FKG R C ++P + C
Sbjct: 1026 QCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR-CTDEAKSNPEE--------CR 1076
Query: 533 GYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVFV 592
G +F +G + +S + N +FDN++++M +F
Sbjct: 1077 G------------LFILYKDGDV--------DSPVVRERIWQNSDFNFDNVLSAMMALFT 1116
Query: 593 IMSANTFTDLMYFTMDTDN----------MAACLFFIVSILCLTVWMVNLLIAVLYSSFE 642
+ + + L+Y +D++ + +FFI+ I+ + +M+N+ + + +F+
Sbjct: 1117 VSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ 1176
Query: 643 VVHEKY----TIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFF 698
EK +DK Q + L I K W +E + F
Sbjct: 1177 EQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKF--WYVVNSSPFEYM--MF 1232
Query: 699 VLAIFTSIC-ALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLAKP 757
VL + ++C A+ + A DI +N + + + VE +L++I + P + +
Sbjct: 1233 VLIMLNTLCLAMQHYEQSKMFNDAMDI--LNMVFTGVFTVEMVLKVIAF--KPKGYFSDA 1288
Query: 758 NYVYDFII---SIICAVLSF--------------------NSLRISLGQTSAWLLFFPIS 794
+D +I SII LS S RIS+ FF +
Sbjct: 1289 WNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISI-------TFFRLF 1341
Query: 795 RFYRVVILFSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYF-----------D 843
R R+V L S + ++W + ++A LI +L+F
Sbjct: 1342 RVMRLVKLLSRGEGI-------RTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK 1394
Query: 844 GTLDADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSLYAL------------QRDSPTL 891
+ ++ + F + P A L L + A+ E W + + A
Sbjct: 1395 VAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYT 1454
Query: 892 FSALFGSVLLILWFILSNFVVLNVFVAVIAASFDIEEEDKRLL------QIKHYLKVTYP 945
+ F V I +++L F+++N+FVAVI +FD D +L + K P
Sbjct: 1455 CGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDP 1514
Query: 946 E---RIREFSVVPLLERIR 961
E RI+ VV LL RI+
Sbjct: 1515 EAKGRIKHLDVVTLLRRIQ 1533
Score = 62.8 bits (151), Expect = 5e-09
Identities = 61/251 (24%), Positives = 110/251 (43%), Gaps = 38/251 (15%)
Query: 411 PRAFTRSSWGRLELLSTISAWLAYGLSI--------NDYDDVHGLRLFRSLMAFRILKLV 462
P A+ R+ W L+ + I + L N G ++L AFR+L+ +
Sbjct: 189 PNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPL 248
Query: 463 DLDSGLVS---ILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPND 519
L SG+ S +L ++ + LL++ ++L+ + + I+G++ F G + + C
Sbjct: 249 RLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCF------ 302
Query: 520 PSDYYQYDMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPAN-SKCISN-ANPYNGR 577
F + AE +P F+ N G C AN ++C S P G
Sbjct: 303 ----------FADSDIVAEE-DPAPCAFSGN-------GRQCTANGTECRSGWVGPNGGI 344
Query: 578 ISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCL-TVWMVNLLIAV 636
+FDN +M VF ++ +TD++Y+ D + VS++ L + +++NL++ V
Sbjct: 345 TNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGV 404
Query: 637 LYSSFEVVHEK 647
L F EK
Sbjct: 405 LSGEFSKEREK 415
Score = 61.2 bits (147), Expect = 2e-08
Identities = 52/231 (22%), Positives = 106/231 (45%), Gaps = 14/231 (6%)
Query: 696 WFFVLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLA 755
W ++ +F + ++S + D Q N+++ + E ++++ + F++
Sbjct: 547 WLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAY-FVS 605
Query: 756 KPNYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVTR------NL 809
N F ++C ++ ++ + L S L + R R++ +F VTR NL
Sbjct: 606 LFNR---FDCFVVCGGIT-ETILVELEIMSP--LGISVFRCVRLLRIFKVTRHWTSLSNL 659
Query: 810 WKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTLI 869
+L + I +L FLF+ + SL+ + F G + D+ + F + P A LT+
Sbjct: 660 VASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVF 719
Query: 870 KIASTENWTDSLY-ALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAV 919
+I + E+W +Y + S + + I+ FI N+++LNVF+A+
Sbjct: 720 QILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAI 770
Score = 57.4 bits (137), Expect = 2e-07
Identities = 65/278 (23%), Positives = 120/278 (42%), Gaps = 15/278 (5%)
Query: 1442 RRICYLWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQ 1501
RR C AV+ FY+ V++ +++L+ LT+ L Q+I V + +
Sbjct: 533 RRRCRA-AVKSVTFYWLVIV--LVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCE 589
Query: 1502 EVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLL 1561
++ +Y ++ Y +N F C VV I + +GIS R V L IF
Sbjct: 590 MLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFK- 648
Query: 1562 VIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVT-KLGPNTTGNINC 1620
V +L+ L+ + S+ SI SL+ F+ +++++ Q+FG T
Sbjct: 649 VTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTF 708
Query: 1621 RTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNII 1680
++L+ +F+ GE WN +M D + A G + G Y +++ I
Sbjct: 709 DNFPQALLTVFQILTGEDWNAVMYDGIM--------AYGGPSSSGMIVCIYFIILF--IC 758
Query: 1681 SMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRK 1718
YI +N+F+++ V+ + + A ++E +K
Sbjct: 759 GNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKK 796
>Hs4506807 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1836
Score = 140 bits (354), Expect = 2e-32
Identities = 135/615 (21%), Positives = 266/615 (42%), Gaps = 63/615 (10%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGF-IYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGE 1227
Y + VF +F +E L+K +A GF +Y NA+C W +D +++ I A LG E
Sbjct: 1067 YADKVFTYIFIMEMLLKWVAYGFKVYFTNAWC---W--LDFLIVDVSIISLVANWLGYSE 1121
Query: 1228 LARIIKAVSALRALRFLTISSMARMTFKQVMFDGLT----YIFGACAVAFSILFPYTVWG 1283
L I K++ LRALR + +++R +V+ + L I V +++ G
Sbjct: 1122 LGPI-KSLRTLRALR--PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMG 1178
Query: 1284 LNVFRGRLGVCNDGDLSYGECYNEFTNQVFHWDILMPRTYADPILHL------------N 1331
+N+F G+ + C N T++ F + ++ + ++H +
Sbjct: 1179 VNLFAGK----------FYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYD 1228
Query: 1332 SFSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILN 1391
+ + S+ ++ + +GW D++ + S + + Y ++ ++F F LN
Sbjct: 1229 NVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLN 1288
Query: 1392 IFVSFIVGNNARMKGTA-----YLTLAEKSWLE-VKRLLSQVCPDPMPNVFKMNAVRRIC 1445
+F+ I+ N + K ++T +K + +K+L S+ P+P N ++ +
Sbjct: 1289 LFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PQNKIQGMV 1346
Query: 1446 YLWAVEKRNFYFSVLMQFMLYLHILTLLMSKD---QPYGKLPTNQNIQFMVTTSFLLIQE 1502
Y ++ F + + ++ L+++T+++ D Q + N N+ F++ + + +
Sbjct: 1347 YDLVTKQA---FDITIMILICLNMVTMMVETDDQSQLKVDILYNINMIFIIIFTGECVLK 1403
Query: 1503 VMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDV--FQLGIFL 1560
++ + + Y WNIF VVV+ + ++ V + R + ++G L
Sbjct: 1404 MLAL----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVL 1459
Query: 1561 LVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINC 1620
+I + L+ SLP++F++ F++ +Y+I F K N
Sbjct: 1460 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNF 1519
Query: 1621 RTVTKSLILLFRCSFGEGWNYIMND-LTIEEPFCYSEADGSYT----DCGSKAFAYALLM 1675
T S+I LF + GW+ ++N L P C + T DCG+ +
Sbjct: 1520 ETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFC 1579
Query: 1676 SWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFD 1735
S+ IIS I VNM++++I+E F+ E P +++ F W + DPD
Sbjct: 1580 SYIIISFLIVVNMYIAIILENFNVA---TEESSEPLGEDDFEMFYETWEKFDPDATQFIA 1636
Query: 1736 VAYLPKFMHSFDGPL 1750
+ L F+ + PL
Sbjct: 1637 YSRLSDFVDTLQEPL 1651
Score = 89.0 bits (219), Expect = 7e-17
Identities = 111/554 (20%), Positives = 221/554 (39%), Gaps = 98/554 (17%)
Query: 422 LELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILRALKYGIPE 481
+ ++S ++ WL Y ++ ++ R+L A R L+ + G+ ++ AL IP
Sbjct: 1107 VSIISLVANWLGYS-------ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPS 1159
Query: 482 LLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCGGYLNAETLE 541
++NV + L FW+ F I+GV F G YY +N T E
Sbjct: 1160 IMNVLLVCLIFWLIFSIMGVNLFAGKF--------------YY---------CINTTTSE 1196
Query: 542 PMKYVFADNSEGPLAKGFLCPANSKCISNANP-----YNGRISFDNIVNSMELVFVIMSA 596
+N S+C S + N ++++DN+ + + +
Sbjct: 1197 RFDISEVNNK-------------SECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATF 1243
Query: 597 NTFTDLMYFTMDTD----------NMAACLFFIVSILCLTVWMVNLLIAVLYSSFEVVHE 646
+ D+MY +D+ N+ L+F++ I+ + + +NL I V+ +F +
Sbjct: 1244 KGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
Query: 647 KYT-IDKFSTQDNYLVFN-VKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFFVLAIFT 704
K D F T++ +N +K+L K P +G+ + F + I
Sbjct: 1304 KLGGKDIFMTEEQKKYYNAMKKLGS--KKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMI 1361
Query: 705 SICA-LASMKSHSSDQSAQDI---FSVNQIVSCILVVETILRLIL----YCKTPWKFLAK 756
IC + +M + DQS + +++N I I E +L+++ Y W
Sbjct: 1362 LICLNMVTMMVETDDQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWN---- 1417
Query: 757 PNYVYDFIISIICAV-LSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVT---RNLWKK 812
++DF++ I+ V L+ + L + ++R RV+ L R L
Sbjct: 1418 ---IFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFA 1474
Query: 813 VLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTLIKIA 872
++ + ++N+ FL +F+ S+ + F ++D F F + N+ + L +I
Sbjct: 1475 LMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDM-FNFETFGNSIICLFEIT 1533
Query: 873 STENWTDSLYALQRDSPT----------------LFSALFGSVLLILWFILSNFVVLNVF 916
++ W L + P + G + I+S +V+N++
Sbjct: 1534 TSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMY 1593
Query: 917 VAVIAASFDIEEED 930
+A+I +F++ E+
Sbjct: 1594 IAIILENFNVATEE 1607
>CE29459 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1538
Score = 140 bits (353), Expect = 2e-32
Identities = 162/664 (24%), Positives = 278/664 (41%), Gaps = 63/664 (9%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRID-LVVLIALWIDFFAWLLGN-G 1226
Y + F +F E L+K I G + P +YC + WN +D +VV AL+ FA G+ G
Sbjct: 770 YMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEGSAG 829
Query: 1227 ELARIIKAVSALRALRFLTISSMARMTFKQVMFD----GLTYIFGACAVAFSILFPYTVW 1282
+ IK++ LR LR + ++ R+ + +FD L +F V F F + V
Sbjct: 830 KNLNTIKSLRVLRVLR--PLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVI 887
Query: 1283 GLNVFRGRLGVCNDGDLSYGE-CYNEF---TNQVFHWDILMPRTYADPILHLNSFSSAFR 1338
+ +F G+ C D + + C+ +F NQ + P + N+ + A
Sbjct: 888 AVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDPPRVEQREWRLRPFNYDNTIN-AML 946
Query: 1339 SMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIV 1398
+++ + + EGW + QN M +T F +F ++F + F +NIFV+ I+
Sbjct: 947 TLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALII 1006
Query: 1399 GNNARMKGTAYLTLAEKSWLEVKR----LLSQVCPDPMPNVFKMNAVRRICYLWAVEKRN 1454
+T E+ E+ + C D F +NA R ++ +
Sbjct: 1007 -----------ITFQEQGEAELSEGDLDKNQKQCID-----FALNARPRSLFMPEDKNST 1050
Query: 1455 FY----------FSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVT--TSFLLIQE 1502
Y F + M+ + L L+M L + ++ T T+ ++
Sbjct: 1051 KYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYN--NPLFYEEILRLFNTALTAVFTVES 1108
Query: 1503 VMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLLV 1562
++ I +R Y R WN F V V+ + + H V + R +F+ + +
Sbjct: 1109 ILKILAFGVRNYFRDGWNRFDFVTVVGSITDALVTEFGGHFV-SLGFLR-LFRAARLIRL 1166
Query: 1563 IPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNI--NC 1620
+ Q T+ L+ T S ++ + +LF +YAI QVFG L T N N
Sbjct: 1167 LQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNF 1226
Query: 1621 RTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYT-----DCGSKAFAYALLM 1675
++ ++ILLFRC+ GEGW IM ++ C CGS +YA
Sbjct: 1227 QSFFNAVILLFRCATGEGWQDIMM-AAVQGKDCARAGSAEINFEKGQTCGSNV-SYAYFT 1284
Query: 1676 SWNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFD 1735
S+ +S ++ +N+FV++I++ F Y+ R+ + P +E F W + DP G+
Sbjct: 1285 SFVFLSSFLMLNLFVAVIMDNFDYL-TRDSSILGPHHLDE---FIRVWADYDPAATGRIH 1340
Query: 1736 VAYLPKFMHSFDGPLSF-KIWEGRLTVKSLVSKYMKVNPNDPYDVEIDHFGLSKELSSID 1794
+ + + + P+ F K RL K L+ M V + F L +E SI
Sbjct: 1341 YSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIK 1400
Query: 1795 YQKV 1798
+ V
Sbjct: 1401 MRPV 1404
Score = 79.0 bits (193), Expect = 7e-14
Identities = 118/570 (20%), Positives = 227/570 (39%), Gaps = 87/570 (15%)
Query: 411 PRAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVS 470
P ++ R W L+ + A A+G + + L +SL R+L+ + +
Sbjct: 796 PGSYCRDFWNILDGIVVTCALFAFGFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPK 855
Query: 471 ILRALKYGIPELLNVGFMLLYFWVF---FGILGVQTFKGSLKRQCVWFNPNDPSDYYQYD 527
+ + L NV +L+ +++F F ++ VQ F G +F D + +
Sbjct: 856 LKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGK------FFFCTDKNRKF--- 906
Query: 528 MQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSM 587
A T +V+ DN P P + P+N +DN +N+M
Sbjct: 907 ---------ANTCHGQFFVY-DNQNDP-------PRVEQREWRLRPFN----YDNTINAM 945
Query: 588 ELVFVIMSANTFTDLMYFTMDTD----------NMAACLFFIVSILCLTVWMVNLLIAVL 637
+FV+ + + + +MDT + LF+++ + + VN+ +A++
Sbjct: 946 LTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALI 1005
Query: 638 YSSFEVVHE----KYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEK 693
+F+ E + +DK Q N + + + ++TK W +E
Sbjct: 1006 IITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTSPPFE- 1064
Query: 694 LEWFFVLAIFTSICALASMKSHSSDQSAQDIFSV-NQIVSCILVVETILRLIL-----YC 747
+F++ + + MK +++ ++I + N ++ + VE+IL+++ Y
Sbjct: 1065 ---YFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNYF 1121
Query: 748 KTPWKFLAKPNYVYDFIISI----ICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVIL- 802
+ W +DF+ + V F +SLG +L F +R R++
Sbjct: 1122 RDGWNR-------FDFVTVVGSITDALVTEFGGHFVSLG----FLRLFRAARLIRLLQQG 1170
Query: 803 FSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLP 862
+++ LW V + + LF A + + ++ + L+A + F S
Sbjct: 1171 YTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNFQSFF 1230
Query: 863 NAFLTLIKIASTENWTDSLYALQ--RDSPTLFSALF--------GSVLLILWF----ILS 908
NA + L + A+ E W D + A +D SA GS + +F LS
Sbjct: 1231 NAVILLFRCATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQTCGSNVSYAYFTSFVFLS 1290
Query: 909 NFVVLNVFVAVIAASFDIEEEDKRLLQIKH 938
+F++LN+FVAVI +FD D +L H
Sbjct: 1291 SFLMLNLFVAVIMDNFDYLTRDSSILGPHH 1320
Score = 62.4 bits (150), Expect = 7e-09
Identities = 60/246 (24%), Positives = 105/246 (42%), Gaps = 33/246 (13%)
Query: 413 AFTRSSWGRLELLSTISAWLAY------GLSINDYDDVHGLRLFRSLMAFRILKLVDLDS 466
++ RS W ++ + +S + + N D LR R++ R LKLV
Sbjct: 47 SYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIP 106
Query: 467 GLVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQY 526
L +L+++ + LL +G ++L+ + F I+G++ + G+ C +N
Sbjct: 107 SLQVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSAC--YNER-------- 156
Query: 527 DMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISN-ANPYNGRISFDNIVN 585
G + + PM N P+ + C+ P G SFDNI
Sbjct: 157 ------GEIENVSERPMP---CTNKTSPMGVYNCDVKGTTCLQKWIGPNYGITSFDNIGF 207
Query: 586 SMELVFVIMSANTFTDLMYFTMD----TDNMAACLFFIVSILCLTVWMVNLLIAVLYSSF 641
+M VF ++ +T +MY+T D T N A +FI I+ + +M+NL++ VL F
Sbjct: 208 AMITVFQCITMEGWTTVMYYTNDSLGSTYNWA---YFIPLIVLGSFFMLNLVLGVLSGEF 264
Query: 642 EVVHEK 647
E+
Sbjct: 265 AKERER 270
Score = 55.5 bits (132), Expect = 9e-07
Identities = 58/270 (21%), Positives = 112/270 (41%), Gaps = 51/270 (18%)
Query: 1166 WTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFF----AW 1221
W EP F+ +F +E ++K IA GF +Y + WN +D +V+++ + A
Sbjct: 16 WLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPAT 75
Query: 1222 LLGNGEL----ARIIKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILF 1277
N + R ++AV LR L+ ++ ++ K ++ + V F+I+
Sbjct: 76 QTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIII 135
Query: 1278 PYTVWGLNVFRGRLGVCNDGDLSYGECYNE-------------FTNQ-----VFHWDI-- 1317
+ + GL + G + CYNE TN+ V++ D+
Sbjct: 136 -FAIIGLEFYSGAF---------HSACYNERGEIENVSERPMPCTNKTSPMGVYNCDVKG 185
Query: 1318 -LMPRTYADPILHLNSFSS---AFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPY 1373
+ + P + SF + A ++++ +++EGWT ++ S G S Y
Sbjct: 186 TTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLG---------STY 236
Query: 1374 SGIFLILFNFLSMVFILNIFVSFIVGNNAR 1403
+ + I L F+LN+ + + G A+
Sbjct: 237 NWAYFIPLIVLGSFFMLNLVLGVLSGEFAK 266
>Hs4885103 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1966
Score = 138 bits (348), Expect = 8e-32
Identities = 143/627 (22%), Positives = 265/627 (41%), Gaps = 39/627 (6%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGEL 1228
YF+ F +FT+E L+K G ++C + +N +DL+V+ I F +
Sbjct: 895 YFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGI----HSSA 950
Query: 1229 ARIIKAVSALRALRFLTISSMAR--MTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNV 1286
++K + LR LR L + A+ Q +F + I V + F + G+ +
Sbjct: 951 ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQL 1010
Query: 1287 FRGRLGVCND-GDLSYGECYNEFTNQVFHWDILMP----RTYADPILHLNSFSSAFRSMY 1341
F+G+ C D + EC F D+ P R + + + ++ SA +++
Sbjct: 1011 FKGKFYTCTDEAKHTPQECKGSFLVYP-DGDVSRPLVRERLWVNSDFNFDNVLSAMMALF 1069
Query: 1342 EIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNN 1401
+ + EGW LL + + +F I++ + F++NIFV F++
Sbjct: 1070 TVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVI-IT 1128
Query: 1402 ARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFSVLM 1461
R +G E + + + + P+ N + +WA + F LM
Sbjct: 1129 FRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQY--RVWATVN-SAAFEYLM 1185
Query: 1462 QFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARKRWNI 1521
++ L+ + L M + +I MV T I+ V+ I + Y WN
Sbjct: 1186 FLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNT 1245
Query: 1522 FRCVVVMFAFAT----------NIYELIVDHVVVGISNARDVFQLGIFLLVIPQNDTLNE 1571
F ++V+ + ++ E D + I+ R +F++ + ++ + + +
Sbjct: 1246 FDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFR-LFRVMRLVKLLSKGEGIRT 1304
Query: 1572 LMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKL--GPNTTGNINCRTVTKSLIL 1629
L+ T S ++ + ++F +YA+ Q+FG L G N N +T ++++L
Sbjct: 1305 LLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLL 1364
Query: 1630 LFRCSFGEGWNYIMNDLTIEEPFCYSEAD---GSYTDCGSKAFAYALLMSWNIISMYIFV 1686
LFRC+ GE W IM ++ C E+D G CGS FA A +S+ ++ ++ +
Sbjct: 1365 LFRCATGEAWQEIML-ASLPGNRCDPESDFGPGEEFTCGSN-FAIAYFISFFMLCAFLII 1422
Query: 1687 NMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSF 1746
N+FV++I++ F Y+ S + +FK W E DP G+ + +
Sbjct: 1423 NLFVAVIMDNFDYL----TRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRI 1478
Query: 1747 DGPLSF-KIWEGRLTVKSLVSKYMKVN 1772
PL F K+ R+ K LV+ M +N
Sbjct: 1479 QPPLGFGKLCPHRVACKRLVAMNMPLN 1505
Score = 84.3 bits (207), Expect = 2e-15
Identities = 131/604 (21%), Positives = 243/604 (39%), Gaps = 102/604 (16%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSIL 472
+F RS + L+LL + +++G+ + V LR+ R L R L+ ++ GL ++
Sbjct: 923 SFCRSWFNMLDLLVVSVSLISFGIHSSAISVVKILRVLRVL---RPLRAINRAKGLKHVV 979
Query: 473 RALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCG 532
+ + I + N+ + F +GVQ FKG C +D ++ Q C
Sbjct: 980 QCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYT-C--------TDEAKHTPQECK 1030
Query: 533 GYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSMELVFV 592
G + Y D S PL + L N +FDN++++M +F
Sbjct: 1031 GSF-------LVYPDGDVSR-PLVRERLW------------VNSDFNFDNVLSAMMALFT 1070
Query: 593 IMSANTFTDLMYFTMDTD----------NMAACLFFIVSILCLTVWMVNLLIAVLYSSF- 641
+ + + L+Y +D + +FFIV I+ + +M+N+ + + +F
Sbjct: 1071 VSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFR 1130
Query: 642 ---EVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFF 698
E ++ +DK Q + L I + WA +E L F
Sbjct: 1131 AQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYR--VWATVNSAAFEYL-MFL 1187
Query: 699 VLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLAKPN 758
++ + T A+ + + A DI +N + + + +E +L++I + P +
Sbjct: 1188 LILLNTVALAMQHYEQTAPFNYAMDI--LNMVFTGLFTIEMVLKIIAF--KPKHYFTDAW 1243
Query: 759 YVYDFIISIICAVLSFNSLRIS----LGQTSA-----WLLFFPISRFYRVVILFSVTRNL 809
+D +I ++ +++ ++ LG++S + FF + R R+V L S +
Sbjct: 1244 NTFDALI-VVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGI 1302
Query: 810 WKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDM-------EDTPFG----F 858
++W + ++A LI +++F + M + T F
Sbjct: 1303 -------RTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNF 1355
Query: 859 YSLPNAFLTLIKIASTENWTD----SLYALQRDSPTLFS--------ALFGSVLLILWFI 906
+ P A L L + A+ E W + SL + D + F + F I +F+
Sbjct: 1356 QTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFM 1415
Query: 907 LSNFVVLNVFVAVIAASFDIEEEDKRLLQIKHY--LKVTYPE-------RIREFSVVPLL 957
L F+++N+FVAVI +FD D +L H K + E RI+ VV LL
Sbjct: 1416 LCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALL 1475
Query: 958 ERIR 961
RI+
Sbjct: 1476 RRIQ 1479
Score = 73.2 bits (178), Expect = 4e-12
Identities = 60/232 (25%), Positives = 100/232 (42%), Gaps = 16/232 (6%)
Query: 696 WFFVLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLA 755
W +L +F + +AS Q N+++ C+ VE +L+L L
Sbjct: 522 WAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLY--------GLG 573
Query: 756 KPNYVYDFIISIICAVLSFNSLRISLGQTSAWL-LFFPISRFYRVVILFSVTR------N 808
YV F C V+ L +L + A L + R R++ +F VTR N
Sbjct: 574 PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSN 633
Query: 809 LWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTL 868
L +L + I +L FLF+ + SL+ + F G + D F + P A LT+
Sbjct: 634 LVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTKRSTFDTFPQALLTV 693
Query: 869 IKIASTENWTDSLY-ALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAV 919
+I + E+W +Y + F + + I+ FI N+++LNVF+A+
Sbjct: 694 FQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAI 745
Score = 68.2 bits (165), Expect = 1e-10
Identities = 70/305 (22%), Positives = 129/305 (41%), Gaps = 54/305 (17%)
Query: 1140 VATLLMVIYSCYVTPLY---------RMNHNKKWNWTTYFEPVFVPLFTIEFLVKTIADG 1190
+ LL + +C +Y NHN + E VF+ +FT+E ++K +A G
Sbjct: 96 ILILLTIFANCVALGVYIPFPEDDSNTANHNLE-----QVEYVFLVIFTVETVLKIVAYG 150
Query: 1191 FIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGE----------------LARIIKA 1234
+ P+AY N WN +D ++++ + F+ LL G + ++A
Sbjct: 151 LVLHPSAYIRNGWNLLDFIIVV---VGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRA 207
Query: 1235 VSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGR---- 1290
LR LR ++ + +M + + A V F I+ Y + GL +F GR
Sbjct: 208 FRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIII-YAIIGLELFLGRMHKT 266
Query: 1291 ---LGVCNDGDLSYGECYNEFTNQVFHWDILMPR-TYADP---ILHLNSFSSAFRSMYEI 1343
LG + + C + + + + R + P I + ++F A ++++
Sbjct: 267 CYFLGSDMEAEEDPSPCASSGSGRACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQC 326
Query: 1344 VSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNAR 1403
V++EGWTD+L M + G P F S L++F F+LN+ + + G ++
Sbjct: 327 VTMEGWTDVLYWMQDAMGYELPWVYFVS------LVIF---GSFFVLNLVLGVLSGEFSK 377
Query: 1404 MKGTA 1408
+ A
Sbjct: 378 EREKA 382
Score = 55.8 bits (133), Expect = 7e-07
Identities = 48/206 (23%), Positives = 92/206 (44%), Gaps = 36/206 (17%)
Query: 451 RSLMAFRILKLVDLDSGLVS---ILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGS 507
++L AFR+L+ + L SG+ S +L ++ + LL++ ++L+ + + I+G++ F G
Sbjct: 203 KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGR 262
Query: 508 LKRQCVWFNPNDPSDYYQYDMQFCGGYLNAETLEPMKYVFADNSEGPLAK---GFLCPAN 564
+ + C + DM+ A+ P A G C N
Sbjct: 263 MHKTCYFLGS---------DME------------------AEEDPSPCASSGSGRACTLN 295
Query: 565 -SKCISN-ANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSI 622
++C P G +FDN +M VF ++ +TD++Y+ D + VS+
Sbjct: 296 QTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSL 355
Query: 623 LCL-TVWMVNLLIAVLYSSFEVVHEK 647
+ + +++NL++ VL F EK
Sbjct: 356 VIFGSFFVLNLVLGVLSGEFSKEREK 381
Score = 53.1 bits (126), Expect = 4e-06
Identities = 62/263 (23%), Positives = 110/263 (41%), Gaps = 14/263 (5%)
Query: 1437 KMNAVRRICYLWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTS 1496
+ N V R AV+ Y++VL+ +++L+ LT+ L Q V
Sbjct: 502 RANRVLRARCRRAVKSNACYWAVLL--LVFLNTLTIASEHHGQPVWLTQIQEYANKVLLC 559
Query: 1497 FLLIQEVMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQL 1556
++ ++ +YG Y +N F C VV + +GIS R V L
Sbjct: 560 LFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLL 619
Query: 1557 GIFLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVF-GVTKLGPNTT 1615
IF V +L+ L+ + S+ SI SL+ F+ +++++ Q+F G T
Sbjct: 620 RIF-KVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHT 678
Query: 1616 GNINCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLM 1675
T ++L+ +F+ GE WN +M D + A G G Y +++
Sbjct: 679 KRSTFDTFPQALLTVFQILTGEDWNVVMYDGIM--------AYGGPFFPGMLVCIYFIIL 730
Query: 1676 SWNIISMYIFVNMFVSLIVEKFS 1698
I YI +N+F+++ V+ +
Sbjct: 731 F--ICGNYILLNVFLAIAVDNLA 751
>Hs4502529 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2251
Score = 132 bits (332), Expect = 6e-30
Identities = 150/628 (23%), Positives = 267/628 (41%), Gaps = 43/628 (6%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDF-FAWLLGNGE 1227
YF+ VF +FT E ++K I G I +Y + WN +D VV++ + F A LG +
Sbjct: 1169 YFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNK 1228
Query: 1228 LARIIKAVSALRALRFL-TISSMARMTFKQVMFD----GLTYIFGACAVAFSILFPYTVW 1282
R IK + +LR LR L + ++ R+ + +FD L +F V +F + V
Sbjct: 1229 -GRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVI 1287
Query: 1283 GLNVFRGRLGVCNDGDL-SYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMY 1341
+ +F+G+ C D + EC + + + + R + H ++ A +++
Sbjct: 1288 AVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLF 1347
Query: 1342 EIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIV--- 1398
+ + EGW +LQ+ + T IF +++ + F +NIFV+ I+
Sbjct: 1348 TVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITF 1407
Query: 1399 -GNNARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLW-AVEKRNFY 1456
+M L E++ ++ + P+ N +W V +F
Sbjct: 1408 QEQGDKMMEECSLEKNERACIDF-----AISAKPLTRYMPQNRHTFQYRVWHFVVSPSFE 1462
Query: 1457 FSVLMQFMLYLHILTLLM---SKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRL 1513
++++ M+ L+ + L+M S Y NI F + S ++ V+ +
Sbjct: 1463 YTIMA--MIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFS---LECVLKVIAFGFLN 1517
Query: 1514 YARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNAR----DVFQLGIFLLVIPQNDTL 1569
Y R WNIF + V+ + T I ++ D +V S +F+ + ++ Q T+
Sbjct: 1518 YFRDTWNIFDFITVIGSI-TEI--ILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTI 1574
Query: 1570 NELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGN--INCRTVTKSL 1627
L+ T S ++ + +LF +YAI QVFG KL + N N R+ SL
Sbjct: 1575 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSL 1634
Query: 1628 ILLFRCSFGEGWNYIMNDLTIE---EPFCYSEADGSYTDCGSKAFAYALLMSWNIISMYI 1684
+LLFR + GE W IM E EP + + + + AY +S+ ++
Sbjct: 1635 MLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFL 1694
Query: 1685 FVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMH 1744
+N+FV++I++ F Y+ R+ + P +E F W E D G+ + + +
Sbjct: 1695 MLNLFVAVIMDNFEYL-TRDSSILGPHHLDE---FVRVWAEYDRAACGRIHYTEMYEMLT 1750
Query: 1745 SFDGPLSF-KIWEGRLTVKSLVSKYMKV 1771
PL K ++ K LV M V
Sbjct: 1751 LMSPPLGLGKRCPSKVAYKRLVLMNMPV 1778
Score = 60.1 bits (144), Expect = 4e-08
Identities = 49/198 (24%), Positives = 96/198 (47%), Gaps = 23/198 (11%)
Query: 787 WLLFFP-------ISRFYRVVILFSVT------RNLWKKVLKNAIVIWNLSAFYFLFVFL 833
W +F P + R R++ +F +T RNL ++ + I +L FLF+ +
Sbjct: 557 WAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVV 616
Query: 834 ASLIVLLYFDGTLDADDMEDTPFG-FYSLPNAFLTLIKIASTENWTDSLYALQRDSPTLF 892
+L+ + F G + +D TP F + P A +T+ +I + E+W + +Y R +
Sbjct: 617 FALLGMQLFGGRFNFND--GTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVS 674
Query: 893 SALFGSVLLILWFILSNFVVLNVFVAV----IAASFDI---EEEDKRLLQIKHYLKVTYP 945
S ++ ++ I+ + N+ +LNVF+A+ +A + ++ E+E++ KH L+
Sbjct: 675 SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKE 734
Query: 946 ERIREFSVVPLLERIRRK 963
+P +ER RR+
Sbjct: 735 VSPMSAPNMPSIERERRR 752
Score = 53.5 bits (127), Expect = 3e-06
Identities = 71/338 (21%), Positives = 136/338 (40%), Gaps = 22/338 (6%)
Query: 1443 RICYLWAVEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQE 1502
RI V+ + FY+ VL L + ++ +QP +F+ FLL +
Sbjct: 466 RISIRHMVKSQVFYWIVLSLVALNTACVAIV-HHNQPQWLTHLLYYAEFLFLGLFLL-EM 523
Query: 1503 VMHIYGKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLLV 1562
+ +YG RLY +N F V + + ++ + GIS R + L IF +
Sbjct: 524 SLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKIT 583
Query: 1563 IPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRT 1622
+L L+ + +S+ SI SL++ F+ +V+A+ Q+FG + T + N T
Sbjct: 584 -KYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDT 642
Query: 1623 VTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNIISM 1682
+++ +F+ GE WN +M + + G + A + +L +
Sbjct: 643 FPAAIMTVFQILTGEDWNEVM--------YNGIRSQGGVSSGMWSAIYFIVL---TLFGN 691
Query: 1683 YIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKF 1742
Y +N+F+++ V+ + +++ QEE F V +P
Sbjct: 692 YTLLNVFLAIAVDNLANAQELTKDE-----QEEEEAFNQKHALQKAKEVSPMSAPNMPSI 746
Query: 1743 MHSFDGPLSFKIWEGRLTVKSLVSKYMKVNPNDPYDVE 1780
+WE R S + K+M+++ + + E
Sbjct: 747 ERERRRRHHMSVWEQR---TSQLRKHMQMSSQEALNRE 781
>Hs13386500 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2261
Score = 130 bits (328), Expect = 2e-29
Identities = 140/613 (22%), Positives = 267/613 (42%), Gaps = 51/613 (8%)
Query: 1165 NWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLG 1224
N YF+ VF +FT E ++K I G + AY + WN +D +V+ + F
Sbjct: 1275 NVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS 1334
Query: 1225 NGELARIIKAVSALRALRFLTISSMARMTFKQVMFD----GLTYIFGACAVAFSILFPYT 1280
G+ IK++ LR LR + ++ R+ + +FD L +F V +F +
Sbjct: 1335 KGKDINTIKSLRVLRVLR--PLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFA 1392
Query: 1281 VWGLNVFRGRLGVCNDGDLSY-GECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRS 1339
V + +F+G+ C D + +C ++ + R + H ++ A +
Sbjct: 1393 VVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLT 1452
Query: 1340 MYEIVSLEGWTDLLQNMMSST----GVGTPAELFASPYSGIFLILFNFLSMVFILNIFVS 1395
++ + + EGW +L++ + +T G + S + ++ ++F F F +NIFV+
Sbjct: 1453 LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF----FFVNIFVA 1508
Query: 1396 FIV----GNNARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWA-V 1450
I+ +M L E++ ++ + P+ N +W V
Sbjct: 1509 LIIITFQEQGDKMMEEYSLEKNERACIDF-----AISAKPLTRHMPQNKQSFQYRMWQFV 1563
Query: 1451 EKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQN---IQFMVTTSFLLIQEVMHIY 1507
F ++++ M+ L+ + L+M + YG +N + +V TS ++ V+ +
Sbjct: 1564 VSPPFEYTIMA--MIALNTIVLMM---KFYGASVAYENALRVFNIVFTSLFSLECVLKVM 1618
Query: 1508 GKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLLVIPQND 1567
+ Y R WNIF V V+ + T+I + + +S R +F+ + ++ Q
Sbjct: 1619 AFGILNYFRDAWNIFDFVTVLGSI-TDILVTEFGNNFINLSFLR-LFRAARLIKLLRQGY 1676
Query: 1568 TLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGP----------NTTGN 1617
T+ L+ T S ++ + +LF +YAI QVFG + T +
Sbjct: 1677 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEH 1736
Query: 1618 INCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSW 1677
N RT ++L+LLFR + GE W+ IM +P C + +CG++ FAY +S+
Sbjct: 1737 NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP-CDKNSGILTRECGNE-FAYFYFVSF 1794
Query: 1678 NIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVA 1737
+ ++ +N+FV++I++ F Y+ R+ + P +E + W E DP G+
Sbjct: 1795 IFLCSFLMLNLFVAVIMDNFEYL-TRDSSILGPHHLDE---YVRVWAEYDPAACGRIHYK 1850
Query: 1738 YLPKFMHSFDGPL 1750
+ + PL
Sbjct: 1851 DMYSLLRVISPPL 1863
Score = 54.3 bits (129), Expect = 2e-06
Identities = 63/273 (23%), Positives = 118/273 (43%), Gaps = 17/273 (6%)
Query: 1450 VEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGK 1509
V+ + FY++VL L + ++ +QP +F+ F+ + + +YG
Sbjct: 484 VKTQAFYWTVLSLVALNT-LCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS-EMFIKMYGL 541
Query: 1510 SMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLLVIPQNDTL 1569
R Y +N F C V++ + I+ +I GIS R + L IF V +L
Sbjct: 542 GTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFK-VTKYWASL 600
Query: 1570 NELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKSLIL 1629
L+ + S+ SI SL++ F+ +V+A+ Q+FG T N T +++
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMT 660
Query: 1630 LFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMF 1689
+F+ GE WN +M D ++ G G F+ ++ + Y +N+F
Sbjct: 661 VFQILTGEDWNEVMYD--------GIKSQGGVQ--GGMVFSIYFIV-LTLFGNYTLLNVF 709
Query: 1690 VSLIVEKFSYVYHREENKHSPASQEEVRKFKVA 1722
+++ V+ + + +E +EE K+A
Sbjct: 710 LAIAVDNLA---NAQELTKDEQEEEEAANQKLA 739
Score = 53.9 bits (128), Expect = 3e-06
Identities = 32/125 (25%), Positives = 64/125 (50%), Gaps = 1/125 (0%)
Query: 795 RFYRVVILFSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDT 854
R ++V ++ RNL +L + I +L FLF+ + +L+ + F G + D+
Sbjct: 589 RIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTP 647
Query: 855 PFGFYSLPNAFLTLIKIASTENWTDSLYALQRDSPTLFSALFGSVLLILWFILSNFVVLN 914
P F + P A +T+ +I + E+W + +Y + + + S+ I+ + N+ +LN
Sbjct: 648 PTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLN 707
Query: 915 VFVAV 919
VF+A+
Sbjct: 708 VFLAI 712
>Hs13386498 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 2505
Score = 130 bits (328), Expect = 2e-29
Identities = 140/613 (22%), Positives = 267/613 (42%), Gaps = 51/613 (8%)
Query: 1165 NWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLG 1224
N YF+ VF +FT E ++K I G + AY + WN +D +V+ + F
Sbjct: 1275 NVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNS 1334
Query: 1225 NGELARIIKAVSALRALRFLTISSMARMTFKQVMFD----GLTYIFGACAVAFSILFPYT 1280
G+ IK++ LR LR + ++ R+ + +FD L +F V +F +
Sbjct: 1335 KGKDINTIKSLRVLRVLR--PLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFA 1392
Query: 1281 VWGLNVFRGRLGVCNDGDLSY-GECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRS 1339
V + +F+G+ C D + +C ++ + R + H ++ A +
Sbjct: 1393 VVAVQLFKGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLT 1452
Query: 1340 MYEIVSLEGWTDLLQNMMSST----GVGTPAELFASPYSGIFLILFNFLSMVFILNIFVS 1395
++ + + EGW +L++ + +T G + S + ++ ++F F F +NIFV+
Sbjct: 1453 LFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPF----FFVNIFVA 1508
Query: 1396 FIV----GNNARMKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWA-V 1450
I+ +M L E++ ++ + P+ N +W V
Sbjct: 1509 LIIITFQEQGDKMMEEYSLEKNERACIDF-----AISAKPLTRHMPQNKQSFQYRMWQFV 1563
Query: 1451 EKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQN---IQFMVTTSFLLIQEVMHIY 1507
F ++++ M+ L+ + L+M + YG +N + +V TS ++ V+ +
Sbjct: 1564 VSPPFEYTIMA--MIALNTIVLMM---KFYGASVAYENALRVFNIVFTSLFSLECVLKVM 1618
Query: 1508 GKSMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLLVIPQND 1567
+ Y R WNIF V V+ + T+I + + +S R +F+ + ++ Q
Sbjct: 1619 AFGILNYFRDAWNIFDFVTVLGSI-TDILVTEFGNNFINLSFLR-LFRAARLIKLLRQGY 1676
Query: 1568 TLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGP----------NTTGN 1617
T+ L+ T S ++ + +LF +YAI QVFG + T +
Sbjct: 1677 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEH 1736
Query: 1618 INCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSW 1677
N RT ++L+LLFR + GE W+ IM +P C + +CG++ FAY +S+
Sbjct: 1737 NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP-CDKNSGILTRECGNE-FAYFYFVSF 1794
Query: 1678 NIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVA 1737
+ ++ +N+FV++I++ F Y+ R+ + P +E + W E DP G+
Sbjct: 1795 IFLCSFLMLNLFVAVIMDNFEYL-TRDSSILGPHHLDE---YVRVWAEYDPAACGRIHYK 1850
Query: 1738 YLPKFMHSFDGPL 1750
+ + PL
Sbjct: 1851 DMYSLLRVISPPL 1863
Score = 54.3 bits (129), Expect = 2e-06
Identities = 63/273 (23%), Positives = 118/273 (43%), Gaps = 17/273 (6%)
Query: 1450 VEKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGK 1509
V+ + FY++VL L + ++ +QP +F+ F+ + + +YG
Sbjct: 484 VKTQAFYWTVLSLVALNT-LCVAIVHYNQPEWLSDFLYYAEFIFLGLFMS-EMFIKMYGL 541
Query: 1510 SMRLYARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIFLLVIPQNDTL 1569
R Y +N F C V++ + I+ +I GIS R + L IF V +L
Sbjct: 542 GTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFK-VTKYWASL 600
Query: 1570 NELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKSLIL 1629
L+ + S+ SI SL++ F+ +V+A+ Q+FG T N T +++
Sbjct: 601 RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMT 660
Query: 1630 LFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMF 1689
+F+ GE WN +M D ++ G G F+ ++ + Y +N+F
Sbjct: 661 VFQILTGEDWNEVMYD--------GIKSQGGVQ--GGMVFSIYFIV-LTLFGNYTLLNVF 709
Query: 1690 VSLIVEKFSYVYHREENKHSPASQEEVRKFKVA 1722
+++ V+ + + +E +EE K+A
Sbjct: 710 LAIAVDNLA---NAQELTKDEQEEEEAANQKLA 739
Score = 53.9 bits (128), Expect = 3e-06
Identities = 32/125 (25%), Positives = 64/125 (50%), Gaps = 1/125 (0%)
Query: 795 RFYRVVILFSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDT 854
R ++V ++ RNL +L + I +L FLF+ + +L+ + F G + D+
Sbjct: 589 RIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDE-GTP 647
Query: 855 PFGFYSLPNAFLTLIKIASTENWTDSLYALQRDSPTLFSALFGSVLLILWFILSNFVVLN 914
P F + P A +T+ +I + E+W + +Y + + + S+ I+ + N+ +LN
Sbjct: 648 PTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLN 707
Query: 915 VFVAV 919
VF+A+
Sbjct: 708 VFLAI 712
>Hs7657542 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1791
Score = 129 bits (325), Expect = 4e-29
Identities = 121/597 (20%), Positives = 259/597 (43%), Gaps = 54/597 (9%)
Query: 1173 VFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELARII 1232
+F +F +E ++K +A GF Y + W +D +++I L+ EL +
Sbjct: 1096 IFTHIFILEMVLKWVAFGF----GKYFTSAWCCLDFIIVIVS----VTTLINLMEL-KSF 1146
Query: 1233 KAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRLG 1292
+ + ALR LR L+ ++ + + I V + + G+ F G+ G
Sbjct: 1147 RTLRALRPLRALSQFEGMKVVVN-ALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFG 1205
Query: 1293 VCNDGDLSYGECYNEFTNQVFHWDILMPRT--------YADPILHLNSFSSAFRSMYEIV 1344
C +G T+ V ++ I+ ++ + + ++ ++ +A+ ++ ++
Sbjct: 1206 KCING-----------TDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVA 1254
Query: 1345 SLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGN-NAR 1403
+ +GW D++ + ST E ++ I+ ++F F LN+F+ I+ N N +
Sbjct: 1255 TFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
Query: 1404 MKGTA----YLTLAEKSWLE-VKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFS 1458
K ++T +K + +K+L S+ P+P +N + + + + F
Sbjct: 1315 QKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR--PLNKCQGLVFDIVTSQ---IFD 1369
Query: 1459 VLMQFMLYLHILTLLM-SKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARK 1517
+++ ++ L++++++ S +QP ++ ++ F L E + + Y
Sbjct: 1370 IIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTL--ECLIKIFALRQYYFTN 1427
Query: 1518 RWNIFRCVVVMFAFATNIYELIV--DHVVVGISNARDV--FQLGIFLLVIPQNDTLNELM 1573
WN+F CVVV+ + + + + +H+ + R V ++G L ++ + L+
Sbjct: 1428 GWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLL 1487
Query: 1574 NTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKSLILLFRC 1633
SLPS+F++ F++ +YAI F N +T S++ LF+
Sbjct: 1488 FALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQI 1547
Query: 1634 SFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMFVSLI 1693
S GW+ +++ + + C S ++ +C A + +S+ IIS I VNM++++I
Sbjct: 1548 STSAGWDSLLSPMLRSKESCNSSSE----NCHLPGIATSYFVSYIIISFLIVVNMYIAVI 1603
Query: 1694 VEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVAYLPKFMHSFDGPL 1750
+E F+ E P +++ F W + DP+ + L F + PL
Sbjct: 1604 LENFNTA---TEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPL 1657
Score = 88.6 bits (218), Expect = 9e-17
Identities = 111/543 (20%), Positives = 222/543 (40%), Gaps = 78/543 (14%)
Query: 417 SSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILRALK 476
S+W L+ + I +S+ ++ L+ FR+L A R L+ + G+ ++ AL
Sbjct: 1120 SAWCCLDFIIVI-------VSVTTLINLMELKSFRTLRALRPLRALSQFEGMKVVVNALI 1172
Query: 477 YGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQFCGGYLN 536
IP +LNV + L FW+ F ILGV F G + C+ N D
Sbjct: 1173 GAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGK-CI--NGTD----------------- 1212
Query: 537 AETLEPMKYVFADNSEGPLAKGFLCPANSKCIS-NANPYNGRISFDNIVNSMELVFVIMS 595
+ Y N S+C S N + N +++FDN+ N+ + + +
Sbjct: 1213 ----SVINYTIITNK-------------SQCESGNFSWINQKVNFDNVGNAYLALLQVAT 1255
Query: 596 ANTFTDLMYFTMDT----------DNMAACLFFIVSILCLTVWMVNLLIAVLYSSFEVVH 645
+ D++Y +D+ N ++F+V I+ + + +NL I V+ +F
Sbjct: 1256 FKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQ 1315
Query: 646 EKYT-IDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAERGIRLYEKLEWFFVLAIFT 704
+K D F T++ +N + K + + + + + F ++ I
Sbjct: 1316 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISL 1375
Query: 705 SICALASMKSHSSDQSAQDIFSVNQIVSCILVVETILRLILYCKTPWKFLAKPNYVYDFI 764
I + SM + S +Q ++ + +V+ T+ LI + ++D +
Sbjct: 1376 IILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCV 1435
Query: 765 ISIICAVLSFNSLRISLGQTSAWLLFFP----------ISRFYRVVILFSVTRNLWKKVL 814
+ +LS S IS + + F P I R R+V R L ++
Sbjct: 1436 V----VLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALM 1491
Query: 815 KNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFLTLIKIAST 874
+ ++N+ FL +F+ +++ + +F ++D F F + ++ L L +I+++
Sbjct: 1492 MSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDI-FNFKTFASSMLCLFQISTS 1550
Query: 875 ENWTDSLYALQRDSPTLFSAL-------FGSVLLILWFILSNFVVLNVFVAVIAASFDIE 927
W L + R + S+ + + + I+S +V+N+++AVI +F+
Sbjct: 1551 AGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTA 1610
Query: 928 EED 930
E+
Sbjct: 1611 TEE 1613
Score = 64.3 bits (155), Expect = 2e-09
Identities = 61/233 (26%), Positives = 107/233 (45%), Gaps = 20/233 (8%)
Query: 413 AFTRSSWGRLELLSTISAWLAY--GLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVS 470
+F R W L+ + A ++Y G++I L R+ FR LK + + S L
Sbjct: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIK-------LLPLRTFRVFRALKAISVVSRLKV 241
Query: 471 ILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQF 530
I+ AL + +L+NV + + F ++G Q F GSL +C+ + + S+ YD F
Sbjct: 242 IVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCF 301
Query: 531 CGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKC-ISNANPYNGRISFDNIVNSMEL 589
+ E M ++ NS C +C + NP +FDN S
Sbjct: 302 EKKENSPEF--KMCGIWMGNS--------ACSIQYECKHTKINPDYNYTNFDNFGWSFLA 351
Query: 590 VFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSFE 642
+F +M+ +++ L T+ T + + FFIV I + +++NL +AV+ ++E
Sbjct: 352 MFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYE 404
Score = 57.4 bits (137), Expect = 2e-07
Identities = 63/298 (21%), Positives = 121/298 (40%), Gaps = 52/298 (17%)
Query: 1161 NKKWNWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFA 1220
N N T E VF ++ E L+K +A GFI ++ +PWN +D +V+ + +
Sbjct: 153 NSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIP 212
Query: 1221 WL------LGNGELARIIKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFS 1274
+ L + R +KA+S + L+ + + ++ R K V LT+ C F+
Sbjct: 213 GITIKLLPLRTFRVFRALKAISVVSRLKVI-VGALLRSVKKLVNVIILTFF---CLSIFA 268
Query: 1275 ILFPYTVWGLNVFRGRLGV-CNDGDL-------SYGECYNE-------------FTNQVF 1313
++ G +F G L + C D +Y C+ + N
Sbjct: 269 LV------GQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSAC 322
Query: 1314 HWDILMPRTYADP---ILHLNSFSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFA 1370
T +P + ++F +F +M+ +++ + W L Q + +TG+
Sbjct: 323 SIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGL-------- 374
Query: 1371 SPYSGIFLILFNFLSMVFILNIFVSFI--VGNNARMKGTAYLTLAEKSWLEVKRLLSQ 1426
YS F I+ FL +++N+ ++ + A + EK + E ++LL +
Sbjct: 375 --YSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKE 430
Score = 53.5 bits (127), Expect = 3e-06
Identities = 59/273 (21%), Positives = 123/273 (44%), Gaps = 43/273 (15%)
Query: 711 SMKSHSSDQSAQDIFSVNQIV-SCILVVETILRLILYCKTPWKFLAKPNYVYDFIISIIC 769
+M+ H + S + + ++ +V + I + E L++I P+ + + ++D I+
Sbjct: 595 AMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIAL--DPYHYFRRGWNIFDSIV---- 648
Query: 770 AVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSV-----TRNLWKKVLKNAI-VIWNL 823
A+LSF + + Q +W P R +RV+ +F + T N K++ N++ + NL
Sbjct: 649 ALLSFADVMNCVLQKRSW----PFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGNL 704
Query: 824 SAFYFLFVFLASLIVLLYFDGTLDADDMED--TPFG----------FYSLPNAFLTLIKI 871
+ + +F+ S++ + F + ++ P G ++FL + +I
Sbjct: 705 TVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRI 764
Query: 872 ASTENWTDSLYALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAVIAASFDIEEEDK 931
E W ++++ +++ S+ ++ IL ++ VVLN+F+A++ SF EE +
Sbjct: 765 LCGE-WIENMWECMQEANA--SSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNG 821
Query: 932 RLLQIKHYLKVTYPERIREFSVVPLLERIRRKF 964
L R+ V L+R RR F
Sbjct: 822 NL-----------EGEARKTKVQLALDRFRRAF 843
>Hs4506811 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1682
Score = 120 bits (302), Expect = 2e-26
Identities = 127/613 (20%), Positives = 259/613 (41%), Gaps = 64/613 (10%)
Query: 1169 YFEPVFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNG-- 1226
Y + +F +F +E L+K +A GF AY N W R+D VV+I + L+G
Sbjct: 970 YADMIFTYIFILEMLLKWMAYGF----KAYFSNGWYRLDFVVVIVFCLS----LIGKTRE 1021
Query: 1227 ELARIIKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNV 1286
EL +I ++ LR LR L+ ++ + ++ L + V I +++ G+++
Sbjct: 1022 ELKPLI-SMKFLRPLRVLSQFERMKVVVRALIKTTLPTL-NVFLVCLMIWLIFSIMGVDL 1079
Query: 1287 FRGRLGVCNDGD----------LSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSA 1336
F GR C D ++ C + N+ W+ + ++ ++ +
Sbjct: 1080 FAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWE--------NAKMNFDNVGNG 1131
Query: 1337 FRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSF 1396
F S+ ++ + GW ++ + + S V + Y + I F + L++ ++
Sbjct: 1132 FLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITV 1191
Query: 1397 IVGNNARMK-----GTAYLTLAE-KSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAV 1450
I+ N + K ++T+ + K + +K+L+ + P+P +N ++ +
Sbjct: 1192 IIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPR--PLNKLQGFIFDVVT 1249
Query: 1451 EKRNFYFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKS 1510
+ F+V++ ++ + +++ D +I S ++ M K
Sbjct: 1250 SQA---FNVIVMVLICFQAIAMMIDTDVQ----SLQMSIALYWINSIFVMLYTMECILKL 1302
Query: 1511 MRL---YARKRWNIFRCVVVMFAFATNIYELIVDHVVVGISNARDVFQLGIF--LLVIPQ 1565
+ Y WNIF +VV+F+ + V +V S + + I L +
Sbjct: 1303 IAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKG 1362
Query: 1566 NDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTK 1625
+ LM SLP++ +++ F++ +YA+ F K N T
Sbjct: 1363 PKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGN 1422
Query: 1626 SLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYT--------DCGSKAFAYALLMSW 1677
S++ LF+ + GW+ +++ + + +S+ D DCG+ + +S+
Sbjct: 1423 SMLCLFQVAIFAGWDGMLDAIFNSK---WSDCDPDKINPGTQVRGDCGNPSVGIFYFVSY 1479
Query: 1678 NIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDVA 1737
+IS I VNM++ +++E F + +++NK S+++ RKF W+ DPD D +
Sbjct: 1480 ILISWLIIVNMYIVVVME-FLNIASKKKNK--TLSEDDFRKFFQVWKRFDPDRTQYIDSS 1536
Query: 1738 YLPKFMHSFDGPL 1750
L F + D PL
Sbjct: 1537 KLSDFAAALDPPL 1549
Score = 67.8 bits (164), Expect = 2e-10
Identities = 55/252 (21%), Positives = 111/252 (43%), Gaps = 14/252 (5%)
Query: 412 RAFTRSSW-GRLELLSTISAWLAYGLSIND----YDDVHGLRLFRSLMAFRILKLVDLDS 466
+ F R W G L WL + +++ + Y + + ++ RILK++ L+
Sbjct: 162 KLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQ 221
Query: 467 GLVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWF---NPNDPSDY 523
GL S++ L + + +L+ V + L+F F ++G+ F G+LK +C + N N+
Sbjct: 222 GLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHN 281
Query: 524 YQYDMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCI-SNANPYNGRISFDN 582
+ + N LE +Y + + CP C+ + NP G +FD+
Sbjct: 282 RTGNPYYIRETENFYYLEGERYALLCGNRTDAGQ---CPEGYVCVKAGINPDQGFTNFDS 338
Query: 583 IVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSFE 642
++ +F +M+ + L + + +FF+V + +M +L + +L ++E
Sbjct: 339 FGWALFALFRLMAQDYPEVLYHLILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYE 398
Query: 643 VVHEKYTIDKFS 654
EK + + S
Sbjct: 399 --EEKQRVGEIS 408
>Hs10864077 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-forming alpha1I
subunit
Length = 2353
Score = 108 bits (271), Expect = 7e-23
Identities = 110/566 (19%), Positives = 233/566 (40%), Gaps = 45/566 (7%)
Query: 1173 VFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLL--GNGELAR 1230
+F +F E +VK +A G + +AY + WN +D ++++ +D + G ++
Sbjct: 1334 IFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILG 1393
Query: 1231 IIKAVSALRALRFLTISSMAR--MTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFR 1288
+++ + LR LR L + S A + + L I + + + + G+ +F+
Sbjct: 1394 VLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFK 1453
Query: 1289 GRLGVCNDGDLSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMYEIVSLEG 1348
G+ C D + + W + R Y + ++ A S++ + S +G
Sbjct: 1454 GKFYYCEGPDTRNISTKAQCRAAHYRW---VRRKY-----NFDNLGQALMSLFVLSSKDG 1505
Query: 1349 WTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGN----NARM 1404
W +++ + + + GV +P+ ++ I F + F+LN+FV +V N
Sbjct: 1506 WVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Query: 1405 KGTAYLTLAEKSWLEVKRLLSQVCPDP----MPNVFKMNAVRRICYLWAVEKRNFYFSVL 1460
+ EK ++R P P P + RR + + Y +
Sbjct: 1566 EAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCT---SHYLDLF 1622
Query: 1461 MQFMLYLHILTLLMSK-DQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARKRW 1519
+ F++ ++++T+ M +QP + ++ T F + + + + R + + RW
Sbjct: 1623 ITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVF-VFEAALKLVAFGFRRFFKDRW 1681
Query: 1520 NIFRCVVVMFAFATNIYELIVDHVVVGIS----NARDVFQLGIFLLVIPQNDTLNELMNT 1575
N +V+ + E I + I+ V ++ L ++ + L++T
Sbjct: 1682 NQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDT 1741
Query: 1576 ATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVTKS-----LILL 1630
+LP + +L + +LF +YA ++FG + + R T S + L
Sbjct: 1742 VVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTL 1801
Query: 1631 FRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMFV 1690
FR S G+ WN IM D T+ E + SY S + +++ +++ ++ VN+ V
Sbjct: 1802 FRVSTGDNWNGIMKD-TLRECSREDKHCLSYLPALSPVY----FVTFVLVAQFVLVNVVV 1856
Query: 1691 SLIVEKFSYVYHREENKHSPASQEEV 1716
+++++ H EE+ E+
Sbjct: 1857 AVLMK------HLEESNKEAREDAEL 1876
Score = 82.8 bits (203), Expect = 5e-15
Identities = 121/571 (21%), Positives = 227/571 (39%), Gaps = 108/571 (18%)
Query: 413 AFTRSSW----GRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGL 468
A+ +SSW G L L+S + +A S + LR+ R L R L+++ GL
Sbjct: 1358 AYLQSSWNLLDGLLVLVSLVDIVVAMA-SAGGAKILGVLRVLRLLRTLRPLRVISRAPGL 1416
Query: 469 VSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDM 528
++ L + + N+ + F++ FGILGVQ FKG YY
Sbjct: 1417 KLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKF--------------YY---- 1458
Query: 529 QFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCISNANPYNGRISFDNIVNSME 588
EGP + A + ++ + +FDN+ ++
Sbjct: 1459 ----------------------CEGPDTRNISTKAQCRA-AHYRWVRRKYNFDNLGQALM 1495
Query: 589 LVFVIMSANTFTDLMYFTMD----------TDNMAACLFFIVSILCLTVWMVNLLIAVLY 638
+FV+ S + + ++MY +D N L+FI +L ++ +++N+ + V+
Sbjct: 1496 SLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVV 1555
Query: 639 SSFEVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAER------------ 686
+F + ++ ++ KRL L + + T SP R
Sbjct: 1556 ENFHKCRQHQEAEEARRREE------KRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRS 1609
Query: 687 --GIRLYEKLEWFFVLAIFTSICALASMKSHSSDQSAQDIFS-VNQIVSCILVVETILRL 743
+ L+ F I ++ + SM+ ++ +S + N + + + V E L+L
Sbjct: 1610 IHSLCTSHYLDLFITFIICVNVITM-SMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKL 1668
Query: 744 IL-----YCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYR 798
+ + K W L + ++S++ L + +L + + R R
Sbjct: 1669 VAFGFRRFFKDRWNQLD----LAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIAR 1724
Query: 799 VVILFSVT---RNLWKKVLKNAIVIWNLSAFYFLFVFL-ASLIVLLYFDGTLDADDMEDT 854
V+ L + R L V++ + NL + L F+ A+L V L+ G L+ ED
Sbjct: 1725 VLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF--GRLECS--EDN 1780
Query: 855 P-------FGFYSLPNAFLTLIKIASTENWT----DSLYALQRDSPTLFSAL--FGSVLL 901
P F + AFLTL ++++ +NW D+L R+ S L V
Sbjct: 1781 PCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYF 1840
Query: 902 ILWFILSNFVVLNVFVAVIAASFDIEEEDKR 932
+ + +++ FV++NV VAV+ + ++ R
Sbjct: 1841 VTFVLVAQFVLVNVVVAVLMKHLEESNKEAR 1871
Score = 75.5 bits (184), Expect = 8e-13
Identities = 58/275 (21%), Positives = 117/275 (42%), Gaps = 49/275 (17%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRL--FRSLMAFRILKLVDLDSGLV 469
+ + +W RL+ ++ + Y L D H + L R++ R L+ ++ +
Sbjct: 164 KCYLGDTWNRLDFFIVVAGMMEYSL------DGHNVSLSAIRTVRVLRPLRAINRVPSMR 217
Query: 470 SILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYDMQ 529
++ L +P L NV + + + FGI+GVQ + G L+ +C D + ++
Sbjct: 218 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL----DSAFVRNNNLT 273
Query: 530 FCGGYLNAETLEPMKYVFADNSEGPLAKGFLCP--------------------------A 563
F Y E E ++ + + + K P A
Sbjct: 274 FLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAA 333
Query: 564 NSKCIS-----------NANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNM 612
+ CI+ ++NP+NG I+FDNI + +F +++ + D+MY+ MD +
Sbjct: 334 RNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSF 393
Query: 613 AACLFFIVSILCLTVWMVNLLIAVLYSSFEVVHEK 647
++FI+ I+ + +M+NL + V+ + F ++
Sbjct: 394 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR 428
>Hs20070163 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-forming alpha1I
subunit
Length = 2377
Score = 107 bits (266), Expect = 2e-22
Identities = 117/631 (18%), Positives = 256/631 (40%), Gaps = 78/631 (12%)
Query: 1143 LLMVIYSCYVTPLYRMN---HNKKWNWTTYFEPVFVPLFTIEFLVKTIADGFIYTPNAYC 1199
L+++ +C + R H+ + + T +F +F E VK +A G+ + AY
Sbjct: 1283 LVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYL 1342
Query: 1200 LNPWNRIDLVVLIALWIDFFAWLLGNGE-----LARIIKAVSALRALRFLTISSMARMTF 1254
+ WN +D ++++ ID ++ + + R+++ + LR LR ++ + ++
Sbjct: 1343 RSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVV 1402
Query: 1255 KQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRLGVCNDGDLSYGECYNEFTNQVFH 1314
+ +M L I + + + + G+ +F+G+ VC D ++ +
Sbjct: 1403 ETLM-SSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYR 1461
Query: 1315 WDILMPRTYADPILHLNSFSSAFRSMYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYS 1374
W + Y + ++ A S++ + S +GW D++ + + + GV + +P+
Sbjct: 1462 W---VRHKY-----NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWM 1513
Query: 1375 GIFLILFNFLSMVFILNIFVSFIVGN-----------NARMKGTAYLTLAEK-------- 1415
++ I F + F+LN+FV +V N AR + L EK
Sbjct: 1514 LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLD 1573
Query: 1416 ----SWLEVKRLLSQVCPDPMPNVFKMN-AVRRICYLWAVEKRNFYFSVLMQFMLYLHIL 1470
S C + + V +C + Y + + ++ L+++
Sbjct: 1574 DVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLC-------TSHYLDLFITGVIGLNVV 1626
Query: 1471 TLLMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARKRWNIFRCVVVMFA 1530
T+ M Q L I + T +++ V + R + + RWN +V+ +
Sbjct: 1627 TMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLS 1686
Query: 1531 FATNIYELIVDHVVVGIS----NARDVFQLGIFLLVIPQNDTLNELMNTATASLPSIFSL 1586
E I + + I+ V ++ L ++ + L++T +LP + +L
Sbjct: 1687 IMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNL 1746
Query: 1587 VYTWFILFLVYAIALNQVFGVTK---------LGPNTTGNINCRTVTKSLILLFRCSFGE 1637
+ +LF ++A ++FG + LG + T R + + LFR S G+
Sbjct: 1747 GLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHAT----FRNFGMAFLTLFRVSTGD 1802
Query: 1638 GWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNIISMYIFVNMFVSLIVEKF 1697
WN IM D T+ + C E + C + + +S+ + + ++ VN+ ++++++
Sbjct: 1803 NWNGIMKD-TLRD--CDQE-----STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK-- 1852
Query: 1698 SYVYHREENKHSPASQEEVRKFKVAWREIDP 1728
+ E NK + E + ++ + + P
Sbjct: 1853 ---HLEESNKEAKEEAELEAELELEMKTLSP 1880
Score = 78.6 bits (192), Expect = 1e-13
Identities = 59/266 (22%), Positives = 118/266 (44%), Gaps = 36/266 (13%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + +W RL+ I+ L Y L + + R++ R L+ ++ + +
Sbjct: 145 KCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS----FSAVRTVRVLRPLRAINRVPSMRIL 200
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPN--------DPSDY 523
+ L +P L NV + + + FGI+GVQ + G L+ +C F P D Y
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENFSLPLSVDLERY 258
Query: 524 YQYDMQFCGGYLNAETLE-------PMKYVFADNSEGPLA----KGFLCPANSKCIS--- 569
YQ + + ++ ++ E + + D GP + + +N+ C++
Sbjct: 259 YQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQ 318
Query: 570 --------NANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVS 621
NP+ G I+FDNI + +F +++ + D+MYF MD + ++FI+
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 622 ILCLTVWMVNLLIAVLYSSFEVVHEK 647
I+ + +M+NL + V+ + F ++
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQR 404
Score = 56.2 bits (134), Expect = 5e-07
Identities = 57/242 (23%), Positives = 113/242 (46%), Gaps = 24/242 (9%)
Query: 699 VLAIFTSICALASMKSHSSDQSAQDIFSVNQIV-SCILVVETILRLILYCKTPWKFLAKP 757
++AI + ++ ++ H + + ++ IV + + +E +L+L++Y P+ ++ P
Sbjct: 750 MIAILVNTLSMG-IEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY--GPFGYIKNP 806
Query: 758 NYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVTRNLWKKVLKNA 817
++D +I +I S+ +GQ L R RV+ L L ++++
Sbjct: 807 YNIFDGVIVVI-------SVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLM 859
Query: 818 IVIWNLSAF---YFLFVFLASLIVLLYFD----GTLDADDMEDTPFGFYSLPNAFLTLIK 870
+ N++ F LF+F+ S++ + F D D + D F SL A +T+ +
Sbjct: 860 KTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK-NFDSLLWAIVTVFQ 918
Query: 871 IASTENWTDSLYALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAVIAASFDIEEED 930
I + E+W LY S + ++AL+ L+ N+V+ N+ VA++ F EE
Sbjct: 919 ILTQEDWNKVLYNGMA-STSSWAALYFIALMTF----GNYVLFNLLVAILVEGFQAEEIS 973
Query: 931 KR 932
KR
Sbjct: 974 KR 975
Score = 54.7 bits (130), Expect = 1e-06
Identities = 51/218 (23%), Positives = 93/218 (42%), Gaps = 35/218 (16%)
Query: 1173 VFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRID-LVVLIALWIDFFAWLLGNGELARI 1231
VF LF +E L+K + +Y P Y NP+N D ++V+I++W + G + R
Sbjct: 781 VFTSLFALEMLLKLL----VYGPFGYIKNPYNIFDGVIVVISVW-EIVGQQGGGLSVLRT 835
Query: 1232 IKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFRGRL 1291
+ + L+ +RFL + + M + T+ C + +F +++ G+++F +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATF----CMLLMLFIFIFSILGMHLFGCKF 891
Query: 1292 GVCNDGDLSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMYEIVSLEGWTD 1351
DG D L R D +L A ++++I++ E W
Sbjct: 892 ASERDG------------------DTLPDRKNFDSLLW------AIVTVFQILTQEDWNK 927
Query: 1352 LLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFI 1389
+L N M+ST A G + +LFN L + +
Sbjct: 928 VLYNGMASTSSWAALYFIALMTFGNY-VLFNLLVAILV 964
>Hs18581612 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 481
Score = 105 bits (263), Expect = 6e-22
Identities = 79/254 (31%), Positives = 124/254 (48%), Gaps = 28/254 (11%)
Query: 1559 FLLVIPQNDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNI 1618
F + ++ TL L+ T S+ F ++ F+L L YA A +FG K G N +
Sbjct: 54 FFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHA 113
Query: 1619 NCRTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSY--TDCGSKAFAYALLMS 1676
N + K++ +LFR GE WN IM+D ++ PFC + + +Y TDCG+ A A S
Sbjct: 114 NFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPD-EFTYWATDCGNYAGALMYFCS 172
Query: 1677 WNIISMYIFVNMFVSLIVEKFSYVYHREENKHSPASQEEVRKFKVAWREIDPDGVGQFDV 1736
+ +I YI +N+ V++IVE FS Y EE++ S ++R F++ W +D G
Sbjct: 173 FYVIIAYIMLNLLVAIIVENFSLFYSTEEDQ--LLSYNDLRHFQIIWNMVDDKREG---- 226
Query: 1737 AYLPKFMHSFDGPLSFKIWEGRLTV----KSLVSKYMKVNPNDPYDVEIDHFG----LSK 1788
+P F F ++ GRL V L+ K+M Y++E H G
Sbjct: 227 -VIPTFRVKF----LLRLLRGRLEVDLDKDKLLFKHM------CYEMERLHNGGDVTFHD 275
Query: 1789 ELSSIDYQKVNARR 1802
LS + Y+ V+ R+
Sbjct: 276 VLSMLSYRSVDIRK 289
>HsM10863883 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-forming alpha1I
subunit
Length = 2016
Score = 104 bits (259), Expect = 2e-21
Identities = 112/552 (20%), Positives = 225/552 (40%), Gaps = 59/552 (10%)
Query: 1173 VFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLL--GNGELAR 1230
+F +F E +K ++ G + AY + WN +D ++ ID L G ++
Sbjct: 1210 IFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILG 1269
Query: 1231 IIKAVSALRALRFLTISSMAR--MTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFR 1288
+++ + LR LR L + S A + + L I + + + + G+ +F+
Sbjct: 1270 VLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFK 1329
Query: 1289 GR----LGVCNDGDLSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMYEIV 1344
G+ LGV + +C V H + ++ A S++ +
Sbjct: 1330 GKFYHCLGVDTRNITNRSDCMAANYRWVHHK------------YNFDNLGQALMSLFVLA 1377
Query: 1345 SLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNARM 1404
S +GW +++ N + + V +P+ ++ I F + F+LN+FV +V N +
Sbjct: 1378 SKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKC 1437
Query: 1405 KGTAYLTLAEK------SWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFS 1458
+ A + LE KR +Q P + +C + Y
Sbjct: 1438 RQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMC-------TSHYLD 1490
Query: 1459 VLMQFMLYLHILTL-LMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARK 1517
+ + F++ L+++T+ L +QP + +M TT F+L + V+ + +R + +
Sbjct: 1491 IFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL-EAVLKLVAFGLRRFFKD 1549
Query: 1518 RWNIFRCVVVMFAFATNIYELIVDHVVVGIS----NARDVFQLGIFLLVIPQNDTLNELM 1573
RWN +V+ + E I + + I+ V ++ L ++ + L+
Sbjct: 1550 RWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALL 1609
Query: 1574 NTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVT-----KSLI 1628
+T +LP + +L + +LF +YA ++FG R T + +
Sbjct: 1610 DTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFL 1669
Query: 1629 LLFRCSFGEGWNYIM----NDLTIEEPFCYSEADGSYTDCGSKAFAYAL-LMSWNIISMY 1683
LF+ S G+ WN IM D T +E C S S F L +S+ + + +
Sbjct: 1670 TLFQVSTGDNWNGIMKDTLRDCTHDERSCLS----------SLQFVSPLYFVSFVLTAQF 1719
Query: 1684 IFVNMFVSLIVE 1695
+ +N+ V+++++
Sbjct: 1720 VLINVVVAVLMK 1731
Score = 79.3 bits (194), Expect = 6e-14
Identities = 121/559 (21%), Positives = 231/559 (40%), Gaps = 102/559 (18%)
Query: 412 RAFTRSSW----GRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSG 467
+A+ RSSW G L +S I ++ S + LR+ R L R L+++ G
Sbjct: 1233 QAYLRSSWNVLDGFLVFVSIIDIVVSLA-SAGGAKILGVLRVLRLLRTLRPLRVISRAPG 1291
Query: 468 LVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYD 527
L ++ L + + N+ + F++ FGILGVQ FKG C+ + + ++
Sbjct: 1292 LKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH-CLGVDTRNITN----- 1345
Query: 528 MQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCIS-NANPYNGRISFDNIVNS 586
S C++ N + + +FDN+ +
Sbjct: 1346 ------------------------------------RSDCMAANYRWVHHKYNFDNLGQA 1369
Query: 587 MELVFVIMSANTFTDLMYFTMD----------TDNMAACLFFIVSILCLTVWMVNLLIAV 636
+ +FV+ S + + ++MY +D N L+FI +L ++ +++N+ + V
Sbjct: 1370 LMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGV 1429
Query: 637 LYSSFEVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAE--------RGI 688
+ +F + ++ ++ KRL L K + + P +A +
Sbjct: 1430 VVENFHKCRQHQEAEEARRREE------KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSM 1483
Query: 689 RLYEKLEWFFVLAIFTSICALASMKSHSSDQSAQDIFS-VNQIVSCILVVETILRLIL-- 745
L+ F I ++ + S++ ++ S + N + + + V+E +L+L+
Sbjct: 1484 CTSHYLDIFITFIICLNVVTM-SLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFG 1542
Query: 746 ---YCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVIL 802
+ K W L + ++S++ L + +L + + R RV+ L
Sbjct: 1543 LRRFFKDRWNQLD----LAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1598
Query: 803 FSVT---RNLWKKVLKNAIVIWNLSAFYFLFVFL-ASLIVLLYFDGTLDADDMEDTPFG- 857
+ R L V++ + NL + L F+ A+L V L+ G L +D E+ G
Sbjct: 1599 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF--GKLVCND-ENPCEGM 1655
Query: 858 -----FYSLPNAFLTLIKIASTENWT----DSLYALQRDSPTLFSAL-FGSVLLILWFIL 907
F + AFLTL ++++ +NW D+L D + S+L F S L + F+L
Sbjct: 1656 SRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVL 1715
Query: 908 -SNFVVLNVFVAVIAASFD 925
+ FV++NV VAV+ D
Sbjct: 1716 TAQFVLINVVVAVLMKHLD 1734
Score = 76.6 bits (187), Expect = 4e-13
Identities = 56/269 (20%), Positives = 118/269 (43%), Gaps = 37/269 (13%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + +W RL+ ++ + Y L + + + L R++ R LK ++ + +
Sbjct: 143 KCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKAINRVPSMRIL 198
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCV---------------WFN 516
+ L +P L NV + + + FGI+GVQ + G L+ +C ++
Sbjct: 199 VNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQ 258
Query: 517 PNDPSDY-YQYDMQFCGGYLNAETLEPMK-------------YVFADNSEGPLAKGFLCP 562
P + + + + G + + P+K Y F + A G
Sbjct: 259 PEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVN 318
Query: 563 AN---SKC-ISNANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFF 618
N + C +ANP+ G I+FDNI + ++F +++ + ++MY+ MD + ++F
Sbjct: 319 WNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYF 378
Query: 619 IVSILCLTVWMVNLLIAVLYSSFEVVHEK 647
I+ I+ + +M+NL + V+ + F ++
Sbjct: 379 ILLIIVGSFFMINLCLVVIATQFSETKQR 407
>Hs21361077 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-forming alpha1I
subunit
Length = 2223
Score = 104 bits (259), Expect = 2e-21
Identities = 112/552 (20%), Positives = 225/552 (40%), Gaps = 59/552 (10%)
Query: 1173 VFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLL--GNGELAR 1230
+F +F E +K ++ G + AY + WN +D ++ ID L G ++
Sbjct: 1210 IFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILG 1269
Query: 1231 IIKAVSALRALRFLTISSMAR--MTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVFR 1288
+++ + LR LR L + S A + + L I + + + + G+ +F+
Sbjct: 1270 VLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFK 1329
Query: 1289 GR----LGVCNDGDLSYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMYEIV 1344
G+ LGV + +C V H + ++ A S++ +
Sbjct: 1330 GKFYHCLGVDTRNITNRSDCMAANYRWVHHK------------YNFDNLGQALMSLFVLA 1377
Query: 1345 SLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNARM 1404
S +GW +++ N + + V +P+ ++ I F + F+LN+FV +V N +
Sbjct: 1378 SKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKC 1437
Query: 1405 KGTAYLTLAEK------SWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNFYFS 1458
+ A + LE KR +Q P + +C + Y
Sbjct: 1438 RQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMC-------TSHYLD 1490
Query: 1459 VLMQFMLYLHILTL-LMSKDQPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSMRLYARK 1517
+ + F++ L+++T+ L +QP + +M TT F+L + V+ + +R + +
Sbjct: 1491 IFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL-EAVLKLVAFGLRRFFKD 1549
Query: 1518 RWNIFRCVVVMFAFATNIYELIVDHVVVGIS----NARDVFQLGIFLLVIPQNDTLNELM 1573
RWN +V+ + E I + + I+ V ++ L ++ + L+
Sbjct: 1550 RWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALL 1609
Query: 1574 NTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPNTTGNINCRTVT-----KSLI 1628
+T +LP + +L + +LF +YA ++FG R T + +
Sbjct: 1610 DTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFL 1669
Query: 1629 LLFRCSFGEGWNYIM----NDLTIEEPFCYSEADGSYTDCGSKAFAYAL-LMSWNIISMY 1683
LF+ S G+ WN IM D T +E C S S F L +S+ + + +
Sbjct: 1670 TLFQVSTGDNWNGIMKDTLRDCTHDERSCLS----------SLQFVSPLYFVSFVLTAQF 1719
Query: 1684 IFVNMFVSLIVE 1695
+ +N+ V+++++
Sbjct: 1720 VLINVVVAVLMK 1731
Score = 79.3 bits (194), Expect = 6e-14
Identities = 121/559 (21%), Positives = 231/559 (40%), Gaps = 102/559 (18%)
Query: 412 RAFTRSSW----GRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSG 467
+A+ RSSW G L +S I ++ S + LR+ R L R L+++ G
Sbjct: 1233 QAYLRSSWNVLDGFLVFVSIIDIVVSLA-SAGGAKILGVLRVLRLLRTLRPLRVISRAPG 1291
Query: 468 LVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSDYYQYD 527
L ++ L + + N+ + F++ FGILGVQ FKG C+ + + ++
Sbjct: 1292 LKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH-CLGVDTRNITN----- 1345
Query: 528 MQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCIS-NANPYNGRISFDNIVNS 586
S C++ N + + +FDN+ +
Sbjct: 1346 ------------------------------------RSDCMAANYRWVHHKYNFDNLGQA 1369
Query: 587 MELVFVIMSANTFTDLMYFTMD----------TDNMAACLFFIVSILCLTVWMVNLLIAV 636
+ +FV+ S + + ++MY +D N L+FI +L ++ +++N+ + V
Sbjct: 1370 LMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGV 1429
Query: 637 LYSSFEVVHEKYTIDKFSTQDNYLVFNVKRLAHLIKSKSDTTKSPAWAE--------RGI 688
+ +F + ++ ++ KRL L K + + P +A +
Sbjct: 1430 VVENFHKCRQHQEAEEARRREE------KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSM 1483
Query: 689 RLYEKLEWFFVLAIFTSICALASMKSHSSDQSAQDIFS-VNQIVSCILVVETILRLIL-- 745
L+ F I ++ + S++ ++ S + N + + + V+E +L+L+
Sbjct: 1484 CTSHYLDIFITFIICLNVVTM-SLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFG 1542
Query: 746 ---YCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVIL 802
+ K W L + ++S++ L + +L + + R RV+ L
Sbjct: 1543 LRRFFKDRWNQLD----LAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1598
Query: 803 FSVT---RNLWKKVLKNAIVIWNLSAFYFLFVFL-ASLIVLLYFDGTLDADDMEDTPFG- 857
+ R L V++ + NL + L F+ A+L V L+ G L +D E+ G
Sbjct: 1599 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF--GKLVCND-ENPCEGM 1655
Query: 858 -----FYSLPNAFLTLIKIASTENWT----DSLYALQRDSPTLFSAL-FGSVLLILWFIL 907
F + AFLTL ++++ +NW D+L D + S+L F S L + F+L
Sbjct: 1656 SRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVL 1715
Query: 908 -SNFVVLNVFVAVIAASFD 925
+ FV++NV VAV+ D
Sbjct: 1716 TAQFVLINVVVAVLMKHLD 1734
Score = 76.6 bits (187), Expect = 4e-13
Identities = 56/269 (20%), Positives = 118/269 (43%), Gaps = 37/269 (13%)
Query: 412 RAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSI 471
+ + +W RL+ ++ + Y L + + + L R++ R LK ++ + +
Sbjct: 143 KCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKAINRVPSMRIL 198
Query: 472 LRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCV---------------WFN 516
+ L +P L NV + + + FGI+GVQ + G L+ +C ++
Sbjct: 199 VNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQ 258
Query: 517 PNDPSDY-YQYDMQFCGGYLNAETLEPMK-------------YVFADNSEGPLAKGFLCP 562
P + + + + G + + P+K Y F + A G
Sbjct: 259 PEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVN 318
Query: 563 AN---SKC-ISNANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFF 618
N + C +ANP+ G I+FDNI + ++F +++ + ++MY+ MD + ++F
Sbjct: 319 WNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYF 378
Query: 619 IVSILCLTVWMVNLLIAVLYSSFEVVHEK 647
I+ I+ + +M+NL + V+ + F ++
Sbjct: 379 ILLIIVGSFFMINLCLVVIATQFSETKQR 407
>CE29237 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-forming alpha1I
subunit
Length = 1715
Score = 94.4 bits (233), Expect = 2e-18
Identities = 114/571 (19%), Positives = 236/571 (40%), Gaps = 72/571 (12%)
Query: 1190 GFIYT---PNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGELARI---IKAVSALRALRF 1243
G+I+T AY + WN +D ++++ I+ LL G+ +I I+ + LRALR
Sbjct: 1154 GYIFTVIFTAAYFKDGWNILDGILVVISLINIAFELLATGDSPKIFGVIRVLRLLRALRP 1213
Query: 1244 LTISSMARMTFKQVM--FDGLTYIFGACAVAFSILFPYTVWGLNVFRGRLGVCNDGDL-- 1299
L + + A VM L I + + + + G+ +F+G + C ++
Sbjct: 1214 LRVINRAPGVKLVVMTLISSLKPIGNIVLICCTFFIIFGILGVQLFKGMMYHCIGPEVGN 1273
Query: 1300 --SYGECYNEFTNQVFHWDILMPRTYADPILHLNSFSSAFRSMYEIVSLEGWTDLLQNMM 1357
+ +C ++ N+ + + + ++ A S++ + S +GW ++ +
Sbjct: 1274 VTTKADCIEDYRNK-----------WVNHRYNFDNLGQALMSLFVLSSKDGWVSIMYQGI 1322
Query: 1358 SSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVGNNARMKGTAYLTLAEKSW 1417
+ GV + + I+ I F L F+LN+FV +V N + K + EK
Sbjct: 1323 DAVGVDVQPIENYNEWRMIYFISFLLLVGFFVLNMFVGVVVENFHKCKEALEKEMREKEK 1382
Query: 1418 LE--VKRLLSQVCPDPMPNVFKMNAV----RRICYLWAVEKRNFYFSVLMQFMLYLH--- 1468
+ ++L Q + M K N + I +++VE+ Y+ L+LH
Sbjct: 1383 EKRLKRKLKRQKFEESMAGKRKKNRIVWAGSAIKSIFSVERNYPYYHDYGHTRLFLHGIV 1442
Query: 1469 --------------ILTLLMSKD---QPYGKLPTNQNIQFMVTTSFLLIQEVMHIYGKSM 1511
I + M+ + P G + + + T F L + M +
Sbjct: 1443 TSKYFDLAIAAVIGINVISMAMEFYMMPMGLKYVLKALNYFFTAVFTL-EAAMKLIALGF 1501
Query: 1512 RLYARKRWNIFRCVVVMFAFATNIYE------LIVDHVVVGISNARDVFQLGIFLLVIPQ 1565
+ + ++WN +V+ + A I+E L ++ ++ + V ++ L ++
Sbjct: 1502 KRFFIEKWNRLDMFIVILSIAGIIFEEFEALELPINPTIIRVMR---VLRIARVLKLLKM 1558
Query: 1566 NDTLNELMNTATASLPSIFSLVYTWFILFLVYAIALNQVFGVTKLGPN-----TTGNINC 1620
+ L++T +LP + +L +F+LF ++A ++FG + + + +
Sbjct: 1559 AKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFGKLECSEDHPCDGLGEHAHF 1618
Query: 1621 RTVTKSLILLFRCSFGEGWNYIMNDLTIEEPFCYSEADGSYTDCGSKAFAYALLMSWNII 1680
+ + + LFR + G+ WN IM D ++ C S C A + + +I
Sbjct: 1619 KNFGMAFLTLFRIATGDNWNGIMKDALRDD--CDSSDHCETNCCVDPILAPCFFVIFVLI 1676
Query: 1681 SMYIFVNMFVSLIVEKFSYVYHREENKHSPA 1711
S ++ VN+ V+++++ H EE+ A
Sbjct: 1677 SQFVLVNVVVAVLMK------HLEESNKRDA 1701
Score = 65.9 bits (159), Expect = 6e-10
Identities = 59/287 (20%), Positives = 113/287 (38%), Gaps = 49/287 (17%)
Query: 411 PRAFTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVS 470
P A+ +W RL+ ++ + L +++ L R++ R L+ V+ +
Sbjct: 211 PAAYMSDTWNRLDFFIVMAGIAEFVLHEYLGGNIN-LTAIRTVRVLRPLRAVNRIPSMRI 269
Query: 471 ILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCV----------------- 513
++ L +P L NV + + + FGI+GVQ + G L+ +CV
Sbjct: 270 LVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCVINLPKTISENQSALFNN 329
Query: 514 -----WFNPNDPSDYYQYDMQFCGGYLNAETLEPMKY----------------------- 545
++ P D S Y G L P
Sbjct: 330 VKLTRFYIPEDTSLEYICSQPDANGLHTCSNLPPYTVDGVKCNLTLDEYDKVTNDSCINW 389
Query: 546 -VFADNSEGPLAKGFLCPANSKCIS--NANPYNGRISFDNIVNSMELVFVIMSANTFTDL 602
++ + + + + A S I NP+ G +SFDNI + +F+++S +TD+
Sbjct: 390 NIYYNECQVNIYPSLMTIAISCFIKVMQRNPFQGSVSFDNIGFAWVAIFLVISLEGWTDI 449
Query: 603 MYFTMDTDNMAACLFFIVSILCLTVWMVNLLIAVLYSSFEVVHEKYT 649
MY+ D + ++F++ I+ +M+NL + V+ + F + T
Sbjct: 450 MYYVQDAHSFWNWIYFVLLIVIGAFFMINLCLVVIATQFAETKRRET 496
>7290679 [PT] KOG2302 T-type voltage-gated Ca2+ channel pore-forming alpha1I
subunit
Length = 2435
Score = 86.3 bits (212), Expect = 5e-16
Identities = 61/259 (23%), Positives = 115/259 (43%), Gaps = 41/259 (15%)
Query: 414 FTRSSWGRLELLSTISAWLAYGLSINDYDDVHGLRLFRSLMAFRILKLVDLDSGLVSILR 473
+ SW RL+ ++ L Y + + + + L R++ R L+ ++ + ++
Sbjct: 77 YLADSWNRLDFFIVLAGLLEYVMHVENLN----LTAIRTIRVLRPLRAINRIPSMRILVM 132
Query: 474 ALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFN------PNDPSDYYQYD 527
L +P L NV + + + FGI+GVQ ++G L+++C P S YY++
Sbjct: 133 LLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTLSQYYEFS 192
Query: 528 --------------MQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKCI----- 568
M CG + P + +E F P N+ C+
Sbjct: 193 KDQDYICSTPNDSGMHLCGNF------PPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQY 246
Query: 569 ------SNANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSI 622
S NP+ G ISFDNI + +F+++S +TD+MY+ D + ++F++ I
Sbjct: 247 YTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLI 306
Query: 623 LCLTVWMVNLLIAVLYSSF 641
+ + +M+NL + V+ + F
Sbjct: 307 VIGSFFMINLCLVVIATQF 325
Score = 81.3 bits (199), Expect = 1e-14
Identities = 77/386 (19%), Positives = 162/386 (41%), Gaps = 46/386 (11%)
Query: 1173 VFVPLFTIEFLVKTIADGFIYTPNAYCLNPWNRIDLVVLIALWIDFFAWLLGNGE----- 1227
VF +FT+E +K +A G Y +AY + WN +D ++ ID L+
Sbjct: 1973 VFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFG 2032
Query: 1228 LARIIKAVSALRALRFLTISSMARMTFKQVMFDGLTYIFGACAVAFSILFPYTVWGLNVF 1287
+ R+ + + +LR LR + + ++ Q + L I + + + + G+ +F
Sbjct: 2033 ILRVFRLLRSLRPLRVINRAPGLKLVV-QTLLSSLRPIGNIVLICCTFFIIFGILGVQLF 2091
Query: 1288 RGRLGVCNDGDL----SYGECY----NEFTNQVFHWDILMPRTYADPILHLNSFSSAFRS 1339
+G C ++ + EC N +TN+ +++D L A S
Sbjct: 2092 KGTFYYCEGENIKGVRNADECRRIPGNVWTNRKYNFDDL---------------GKALMS 2136
Query: 1340 MYEIVSLEGWTDLLQNMMSSTGVGTPAELFASPYSGIFLILFNFLSMVFILNIFVSFIVG 1399
++ + S +GW +++ + + GV + + + ++ I F L F+LN+FV +V
Sbjct: 2137 LFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVE 2196
Query: 1400 NNAR----MKGTAYLTLAEKSWLEVKRLLSQVCPDPMPNVFKMNAVRRICYLWAVEKRNF 1455
N R + + A K L++++ ++ P + + R + K
Sbjct: 2197 NFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNY--SPTRMFVHNVVTSK--- 2251
Query: 1456 YFSVLMQFMLYLHILTLLMSKDQPYGKLPTNQNIQFMV----TTSFLLIQEVMHIYGKSM 1511
YF + + ++ L+++T+ M Y K+P+ + T+ +++ M +
Sbjct: 2252 YFDLAIAAVIGLNVVTMAME----YYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGW 2307
Query: 1512 RLYARKRWNIFRCVVVMFAFATNIYE 1537
+LY + RWN +V+ + + E
Sbjct: 2308 KLYLKDRWNQLDVGIVLLSIVGIVLE 2333
Score = 54.7 bits (130), Expect = 1e-06
Identities = 61/284 (21%), Positives = 128/284 (44%), Gaps = 27/284 (9%)
Query: 682 AWAERGIRLYEKLEWF---FVLAIFTSICALASMKSHSSDQSAQDIFSVNQIVSCILVVE 738
+W R IR + ++F +LAI + ++ + + + + N + S I VE
Sbjct: 1006 SWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVE 1065
Query: 739 TILRLILYCKTPWKFLAKPNYVYDFIISIICAV-LSFNSLRISLGQTSAWLLFFPISRFY 797
+L+++ + P++++A V+D II I+ A+ + + G + L R
Sbjct: 1066 MLLKVV--AEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLL 1123
Query: 798 RVVILFSVTRNLWKKVLKNAIVIWNLSAFY---FLFVFLASLIVLLYF--------DGTL 846
R++ L NL +++ + N++ F+ LF+F+ S++ + F +G +
Sbjct: 1124 RILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMNLFGCKFCEKVNGEM 1183
Query: 847 DADDMEDTPFGFYSLPNAFLTLIKIASTENWTDSLYALQRDSPTLFSALFGSVLLILWFI 906
D F SL A +T+ +I + E+W L+ + + ++AL+ L+
Sbjct: 1184 ICDRKN-----FDSLLWALVTVFQILTQEDWNVVLFN-GMEKTSHWAALYFVALMTF--- 1234
Query: 907 LSNFVVLNVFVAVIAASFDIEEEDKRLLQIKHYLKVTYPERIRE 950
N+V+ N+ VA++ F E ++R + + +K E + E
Sbjct: 1235 -GNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAE 1277
>CE29575 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 1031
Score = 75.5 bits (184), Expect = 8e-13
Identities = 160/783 (20%), Positives = 298/783 (37%), Gaps = 159/783 (20%)
Query: 451 RSLMAFRILKLVDLDSGLV----SILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKG 506
RS+ F I++L+ L I + LK ++ NV ++F + I G+Q F G
Sbjct: 219 RSIRPFIIIRLIPLVVKFKLPKNRIEQLLKRSSQQVKNVTLFFVFFMTLYAIFGIQLF-G 277
Query: 507 SLKRQCVWFNPNDPSDYYQYDMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSK 566
+ CV DP++ D+ E + G+ CPA
Sbjct: 278 RMDYHCVQ-PKTDPNNVTIMDLAIPDTMCAPEGIG----------------GYECPAPMV 320
Query: 567 CIS---NANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSIL 623
C+ NA F++ S+ V++ S + ++Y MD+ + +++
Sbjct: 321 CMQLNLNAKGEGFYGMFNDFGASVFTVYLAASEEGWVYVLYDCMDSLPSYLAFLYFCTLI 380
Query: 624 CLTVWMV-NLLIAVLYSSFEVVHEKY---------TIDKF------STQDNYLVFNV--- 664
W+V N+ IAV+ +F + ++ T+D+ T D + + +
Sbjct: 381 FFLAWLVKNVFIAVITETFAEIRVQFSEMWQKKEVTLDEGFRKKLEKTDDGWRLIRLDGE 440
Query: 665 ----------KRLAHLIKSKS--DTTKSPAWAERGIR--LYEKLEWFF------------ 698
+ ++ L++ S + K+ +A++ R Y+ E FF
Sbjct: 441 VEPEGPKQKLQWVSSLLRVNSVVEKKKNDTYAKKLARSAYYKNYEQFFPNPIIKTFFQML 500
Query: 699 -------VLAIFTSICALASM----KSHSSDQSAQDIFSVNQIVSCILV-VETILRLILY 746
+ IF I A+ + + +D+ + F + ++ IL VE I++++ Y
Sbjct: 501 RSMYFQCFVIIFVVINAIGNAMFVYRHDETDKPRKYNFYLFEVGFTILFNVECIIKILCY 560
Query: 747 CKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVILFSVT 806
F+ + + ++ I+ C S N ++ + + +F R R++ +
Sbjct: 561 GFR--NFIRRGIFKFELIL---CLGSSLNCVKFFYERN--YFTYFQTFRLLRLIKASPIL 613
Query: 807 RNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPNAFL 866
+ K+ + L F F+ S I L F + F + P AF+
Sbjct: 614 EDFVWKIFSPGKKLGGLVIFTIAFICCYSAISLQLFYSVPNLHH-------FRTFPQAFM 666
Query: 867 TLIKIASTENWTDSLYALQRDSPTLFSALFGSVLLILWFILSNFVVLNVFVAVIAASFDI 926
++ +I + E WTD + + R + L ++ + + + +VL++FVAVI + ++
Sbjct: 667 SMFQIITQEGWTDFVVEVLRATDDNLVPLV-ALYFVAYHLFVTLIVLSLFVAVILDNLEM 725
Query: 927 EEEDKRLLQIK-----HYLKVTYPERIREFSVVPLLERI--RRKFLRKPQIDDSEDFRQF 979
+EE K++ Q++ ++ T P R+R F P ++ RKF+ + DS DF
Sbjct: 726 DEELKKVKQLRAREATTSMRSTLPWRLRVFEKFPTRPQMAAMRKFVMFQYLADS-DFPMP 784
Query: 980 LFRGTAILSIAQNYEGFNMDLSEDKDHQFADRNVKSSFWNRI------------------ 1021
RG+ A ++ D+ E D +F R +KS+ +I
Sbjct: 785 KVRGSFTHQFAVDHSLETTDVIE-SDFEFPKRIMKSAGKRKISKSGLTFRQIGSTSLRCS 843
Query: 1022 ------------------LWRLKALNFYKTN-----PFFKDPKVVFVQSD-DTTPSNRKY 1057
R K N Y N P PK Q + D +K
Sbjct: 844 LNNLLEKSRSMTGKFLQTAVRNKQFNMYSENGDLSRPSDSAPKKNAKQGEIDIRALQQKR 903
Query: 1058 TLK--LNDWEEEKLRFLKQHPNFNNTYFIFPPNHALRRFCQRLVPPSYGKRTNNRVFFDD 1115
L + EE +R + HP F+ F+ LR FC+++V Y + DD
Sbjct: 904 QLAEITRNRIEEDMR--ENHPFFDRPLFLVGRASQLREFCKKMVHSKYDSQ-------DD 954
Query: 1116 TTN 1118
TN
Sbjct: 955 GTN 957
>Hs22051246 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 668
Score = 61.2 bits (147), Expect = 2e-08
Identities = 92/496 (18%), Positives = 196/496 (38%), Gaps = 67/496 (13%)
Query: 413 AFTRSSWGRLELLSTISAWLAYGLSINDYDDVHG-------LRLFRSLM---AFRILKLV 462
++ + W + W++ L + + D+ LR+ R L+ AFRI
Sbjct: 101 SYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRF 160
Query: 463 DLDSGLVSILRALKYGIPELLNVGFMLLYFWVFFGILGVQTFKGSLKRQCVWFNPNDPSD 522
+L I LK ++ +V LL+F + +GILGVQ F G+ CV N P +
Sbjct: 161 ELPR--TRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCV-VNDTKPGN 216
Query: 523 YYQYDMQFCGGYLNAETLEPMKYVFADNSEGPLAKGFLCPANSKC-----ISNANPYNGR 577
+ + + E L +G+ CP KC + + G
Sbjct: 217 VTWNSLAIPDTHCSPE----------------LEEGYQCPPGFKCMDLEDLGLSRQELGY 260
Query: 578 ISFDNIVNSMELVFVIMSANTFTDLMYFTMDTDNMAACLFFIVSILCLTVWMV-NLLIAV 636
F+ I S+ V+ S + LMY +D+ F+ ++++ W+V N+ IAV
Sbjct: 261 SGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAV 320
Query: 637 LYSSFEVVHEKYTIDKFSTQDNYLVFNVKRLAH----------LIKSKSDTTKSPAWAER 686
+ +F + ++ + ++ + ++ H + ++PA ++
Sbjct: 321 IIETFAEIRVQFQ-QMWGSRSSTTSTATTQMFHEDAAGGWQLVAVDVNKPQGRAPACLQK 379
Query: 687 GIRLYEKLEWFFVLAIFTSICALASMKSHSSD--QSAQDIFSVNQIVSCILV-VETILRL 743
+R + F+L++ T +A+ + + + D F + ++ +L +E +L+
Sbjct: 380 MMR--SSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLK- 436
Query: 744 ILYCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPISRFYRVVILF 803
++C +++ + ++ ++ I +L + + +F + R R++ +
Sbjct: 437 -IWCLGFTGYISSSLHKFELLLVI------GTTLHVYPDLYHSQFTYFQVLRVVRLIKIS 489
Query: 804 SVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMEDTPFGFYSLPN 863
+ K+ + +L F + + S I L F + D F + P
Sbjct: 490 PALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELD-------RFTTFPR 542
Query: 864 AFLTLIKIASTENWTD 879
AF+++ +I + E W D
Sbjct: 543 AFMSMFQILTQEGWVD 558
>Hs16876443 [PT] KOG2301 Voltage-gated Ca2+ channels alpha1 subunits
Length = 528
Score = 52.0 bits (123), Expect = 1e-05
Identities = 51/219 (23%), Positives = 96/219 (43%), Gaps = 26/219 (11%)
Query: 734 ILVVETILRLILYCKTPWKFLAKPNYVYDFIISIICAVLSFNSLRISLGQTSAWLLFFPI 793
I ++E +L+ + WK V+DF+++++ + L GQ S WL I
Sbjct: 156 IFILEILLKWLSNFSVFWKSAWN---VFDFVVTMLSLLPEVVVLVGVTGQ-SVWLQLLRI 211
Query: 794 SRFYRVVILFSVTRNLWKKVLKNAIVIWNLSAFYFLFVFLASLIVLLYFDGTLDADDMED 853
R R + L + R + +L +++ L + FL + L + G +
Sbjct: 212 CRVLRSLKLLAQFRQIQIIIL---VLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTR 268
Query: 854 TP-------FGFYSLPNAFLTLIKIASTENWTDSLYALQRD--SPTLFSALFGSVLLILW 904
+P F LPN+ +T+ + + ++W YAL +D S +F S+ ILW
Sbjct: 269 SPRQDLEYHVFFSDLPNSLVTVFILFTLDHW----YALLQDVWKVPEVSRIFSSIYFILW 324
Query: 905 FILSNFVVLNVFVAVIAASFD------IEEEDKRLLQIK 937
+L + + ++ VA++ +F EE +R +Q+K
Sbjct: 325 LLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQLK 363
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.325 0.139 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 118,241,042
Number of Sequences: 60738
Number of extensions: 5263161
Number of successful extensions: 17830
Number of sequences better than 1.0e-05: 39
Number of HSP's better than 0.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 16897
Number of HSP's gapped (non-prelim): 524
length of query: 1969
length of database: 30,389,216
effective HSP length: 121
effective length of query: 1848
effective length of database: 23,039,918
effective search space: 42577768464
effective search space used: 42577768464
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)