ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV4527 check: MH L KOG1564 Replication, recombination and repair DNA repair protein RHP57
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV4527 1555877 1557316 480
(480 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR004w [L] KOG1564 DNA repair protein RHP57 361 2e-99
SPAC20H4.07 [L] KOG1564 DNA repair protein RHP57 94 5e-19
Hs19924117 [L] KOG1433 DNA repair protein RAD51/RHP55 65 2e-10
Hs10835029 [L] KOG1433 DNA repair protein RAD51/RHP55 65 2e-10
SPAC8E11.03c [DL] KOG1434 Meiotic recombination protein Dmc1 65 3e-10
Hs17402896 [DL] KOG1434 Meiotic recombination protein Dmc1 60 9e-09
Hs4885659 [L] KOG1564 DNA repair protein RHP57 59 1e-08
YER179w [DL] KOG1434 Meiotic recombination protein Dmc1 54 7e-07
YER095w [L] KOG1433 DNA repair protein RAD51/RHP55 52 2e-06
ECU11g0820 [L] KOG1433 DNA repair protein RAD51/RHP55 52 2e-06
At3g22880 [DL] KOG1434 Meiotic recombination protein Dmc1 52 2e-06
Hs19924133 [L] KOG1433 DNA repair protein RAD51/RHP55 50 6e-06
>YDR004w [L] KOG1564 DNA repair protein RHP57
Length = 460
Score = 361 bits (926), Expect = 2e-99
Identities = 204/481 (42%), Positives = 287/481 (59%), Gaps = 42/481 (8%)
Query: 1 MDLYEQLPSSGMIHQPEYKFLLDAATFHGITCLDFLSQSPSNLMKTINRSINEIIKFQAA 60
MDLY++LP S +++ E+ +LLDA +G+ +DFL+ +P L + I RSINE+ +FQ
Sbjct: 14 MDLYDELPESKLLYDEEFSYLLDAVRQNGVCVVDFLTLTPKELARLIQRSINEVFRFQQL 73
Query: 61 LRNEFELALADIKIQDITTLKEDDKPRCFTTXXXXXXXXXXXXIYSKGITEIFGESSTGK 120
L +E+ ++I + ++ D+ P CFTT I++ GITEIFGESSTGK
Sbjct: 74 LVHEYNEKY--LEICEKNSISPDNGPECFTTADVAMDELLGGGIFTHGITEIFGESSTGK 131
Query: 121 XXXXXXXXXXXXXPEDMNGLNGQSVYITTEGDLPTRRLKSIIEQSSLFKDEGGDCLVSQK 180
E GL G+ VYITTEGDLPT+RL+S++ ++ G ++Q
Sbjct: 132 SQLLMQLALSVQLSEPAGGLGGKCVYITTEGDLPTQRLESMLSSRPAYEKLG----ITQS 187
Query: 181 KIFTVTCNDWANQEHVTTVQLPVLLERHP-SIKLVIIDSISHHLRVELQSKTFQESRSNR 239
IFTV+CND NQEH+ VQLP+LLER SIKLVIIDSISHHLRVELQ+K+F+ES+ N+
Sbjct: 188 NIFTVSCNDLINQEHIINVQLPILLERSKGSIKLVIIDSISHHLRVELQNKSFRESQENK 247
Query: 240 YIIDSMAENLLSLAQKHNLAIVVANQVSDKLLPEKPI--RQDFKDYDYQLGWNIGWKNST 297
+D MAE L LA ++L++VVANQV DK L P+ R DYDYQLGW +GWKNST
Sbjct: 248 NYLDRMAEKLQILAHDYSLSVVVANQVGDKPLANSPVAHRTYVTDYDYQLGWLVGWKNST 307
Query: 298 IFYRHKFNEI--EKYDETILSDDEDYTLIVDQVARKLQQNVPASVPDTNNKDPAQSVAAL 355
I YR + + ++ ILSDDEDY LI + V ++V D
Sbjct: 308 ILYRQMNSLLGASSNNDEILSDDEDYMLI---------ERVMSTVND------------- 345
Query: 356 RTEALRNNVISQQNSPQPTQSKTXXXXXXXXXXAPFLLSRRKREVDTKVPNLGLTWANHL 415
RN + P ++KT +P +KR+ D +VPNLGLTW+NH+
Sbjct: 346 -----RNYDFFSKKKPPIIENKTVERNSS----SPISRQSKKRKFDYRVPNLGLTWSNHV 396
Query: 416 MTRIKLEKRYKASPMVRTGEFNYNNTTDTSQFWQVQRNLKLVFSTYAVKGEMNFAISGEG 475
TRI L+K +KAS +++ GE + D++ FWQV+R +K+V+ST+A G++ + I+ G
Sbjct: 397 STRILLQKSFKASTIIQRGEAHLYKGGDSASFWQVKRTMKVVYSTFAKPGQIAYQITKRG 456
Query: 476 V 476
+
Sbjct: 457 I 457
>SPAC20H4.07 [L] KOG1564 DNA repair protein RHP57
Length = 354
Score = 94.0 bits (232), Expect = 5e-19
Identities = 64/202 (31%), Positives = 103/202 (50%), Gaps = 19/202 (9%)
Query: 109 ITEIFGESSTGKXXXXXXXXXXXXXPEDMNGLNGQSVYITTEGDLPTRRLKSIIE--QSS 166
+TEI GES +GK P + G+N +V+I+TE L T+RL +
Sbjct: 95 LTEICGESGSGKSQFCMQLCLMVQLPLSLGGMNKAAVFISTESGLETKRLFELARYLPER 154
Query: 167 LFKDEGGDCLVSQ--KKIFTVTCNDWANQEHVTTVQLPVLLERHPSIKLVIIDSISHHLR 224
K + D ++ +++T+ C D +QEH+ QLP+L R I LVI+DS++ + R
Sbjct: 155 YPKADKKDIIIKNPGDRVYTILCPDLESQEHIIQYQLPILFNR-DKIGLVILDSVASNYR 213
Query: 225 VELQSKTFQESRSNRYIIDSMAE----------NLLSLAQKHNLAIVVANQVSDKLLPEK 274
EL+ + S+S+ +D++A+ L +LA +H A+V+ANQVSD+ +P
Sbjct: 214 AELR---YNRSKSHFRDLDNIAKRGNQLGKLAMTLRTLAHQHEAAVVIANQVSDR-IPRD 269
Query: 275 PIRQDFKDYDYQLGWNIGWKNS 296
DYQ W GW ++
Sbjct: 270 YDAIGLFSLDYQSQWFSGWDDT 291
>Hs19924117 [L] KOG1433 DNA repair protein RAD51/RHP55
Length = 350
Score = 65.1 bits (157), Expect = 2e-10
Identities = 67/259 (25%), Positives = 107/259 (40%), Gaps = 19/259 (7%)
Query: 21 LLDAATFHGI-TCLDFLSQSPSNLMKTIN---RSINEII-KFQAALRNEFELALADIKIQ 75
L D + H I TC DFL SP LMK R ++E++ A + + A IK Q
Sbjct: 15 LCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYG-IKAQ 73
Query: 76 DITTLKEDDKPRCFTTXXXXXXXXXXXXIYSKGITEIFGESSTGKXXXXXXXXXXXXXPE 135
D P +T + +TEI G GK P
Sbjct: 74 R----SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPT 129
Query: 136 DMNGLNGQSVYITTEGDLPTRRLKSIIEQ--SSLFKDEGGDCLVSQKKIF--TVTCNDWA 191
+M GL G VYI TE RL I E F E L S K +TC++
Sbjct: 130 NMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVL 189
Query: 192 NQEHVTTVQLPVLLERHPSIKLVIIDSISHHLRVELQSKTFQESRSNRYIIDSMAENLLS 251
+ + +++ ++ + IKLVI+DS++ +R E ++ + + A +L
Sbjct: 190 --QRIESLEEEIISK---GIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKY 244
Query: 252 LAQKHNLAIVVANQVSDKL 270
LA++ ++ +++ NQ++ L
Sbjct: 245 LAEEFSIPVILTNQITTHL 263
>Hs10835029 [L] KOG1433 DNA repair protein RAD51/RHP55
Length = 350
Score = 65.1 bits (157), Expect = 2e-10
Identities = 67/259 (25%), Positives = 107/259 (40%), Gaps = 19/259 (7%)
Query: 21 LLDAATFHGI-TCLDFLSQSPSNLMKTIN---RSINEII-KFQAALRNEFELALADIKIQ 75
L D + H I TC DFL SP LMK R ++E++ A + + A IK Q
Sbjct: 15 LCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYG-IKAQ 73
Query: 76 DITTLKEDDKPRCFTTXXXXXXXXXXXXIYSKGITEIFGESSTGKXXXXXXXXXXXXXPE 135
D P +T + +TEI G GK P
Sbjct: 74 R----SADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPT 129
Query: 136 DMNGLNGQSVYITTEGDLPTRRLKSIIEQ--SSLFKDEGGDCLVSQKKIF--TVTCNDWA 191
+M GL G VYI TE RL I E F E L S K +TC++
Sbjct: 130 NMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVL 189
Query: 192 NQEHVTTVQLPVLLERHPSIKLVIIDSISHHLRVELQSKTFQESRSNRYIIDSMAENLLS 251
+ + +++ ++ + IKLVI+DS++ +R E ++ + + A +L
Sbjct: 190 --QRIESLEEEIISK---GIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKY 244
Query: 252 LAQKHNLAIVVANQVSDKL 270
LA++ ++ +++ NQ++ L
Sbjct: 245 LAEEFSIPVILTNQITTHL 263
>SPAC8E11.03c [DL] KOG1434 Meiotic recombination protein Dmc1
Length = 332
Score = 64.7 bits (156), Expect = 3e-10
Identities = 44/163 (26%), Positives = 74/163 (44%), Gaps = 9/163 (5%)
Query: 104 IYSKGITEIFGESSTGKXXXXXXXXXXXXXPEDMNGLNGQSVYITTEGDLPTRRLKSIIE 163
I S ITE+FGE GK P DM G G+ +I TEG R+K+I E
Sbjct: 110 IQSMSITEVFGEFRCGKTQMSHTLCVTAQLPRDMGGAEGKVAFIDTEGTFRPDRIKAIAE 169
Query: 164 QSSLFKDEGGDCLVSQKKIFTVTCNDWANQEHVTTVQLPVLLERHPSIKLVIIDSISHHL 223
+ + D+ + ++ + N E++T +L + +L+I+DSI
Sbjct: 170 RFGVDADQAMENIIVSR-----AYNSEQQMEYIT--KLGTIFAEDGQYRLLIVDSIMALF 222
Query: 224 RVELQSKTFQESRSNRYIIDSMAENLLSLAQKHNLAIVVANQV 266
RV+ + R + ++ M L ++++ N+A+ V NQV
Sbjct: 223 RVDYSGRGELSERQQK--LNIMLARLNHISEEFNVAVFVTNQV 263
>Hs17402896 [DL] KOG1434 Meiotic recombination protein Dmc1
Length = 376
Score = 59.7 bits (143), Expect = 9e-09
Identities = 46/179 (25%), Positives = 78/179 (42%), Gaps = 27/179 (15%)
Query: 110 TEIFGESSTGKXXXXXXXXXXXXXPEDMNGLNGQSVYITTEGDLPTRRLKSII------- 162
TEI G GK PE G+ G++V+I TEG R+ +
Sbjct: 121 TEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHL 180
Query: 163 ----------EQSSLFKDEGGDCLVSQKKIFTVTCNDWANQEHVTTVQL-PVLLERHPSI 211
E +D D ++S I+ C D+ E + V L P L H +
Sbjct: 181 QLIAEKHKGEEHRKALEDFTLDNILSH--IYYFRCRDYT--ELLAQVYLLPDFLSEHSKV 236
Query: 212 KLVIIDSISHHLRVELQSKTFQESRSNRYIIDSMAENLLSLAQKHNLAIVVANQVSDKL 270
+LVI+D I+ R +L + + +++ +A+ ++SLA H LA+++ NQ++ K+
Sbjct: 237 RLVIVDGIAFPFRHDLDDLSLRTR-----LLNGLAQQMISLANNHRLAVILTNQMTTKI 290
>Hs4885659 [L] KOG1564 DNA repair protein RHP57
Length = 346
Score = 59.3 bits (142), Expect = 1e-08
Identities = 49/167 (29%), Positives = 74/167 (43%), Gaps = 8/167 (4%)
Query: 108 GITEIFGESSTGKXXXXXXXXXXXXXPEDMNGLNGQSVYITTEGDLPTRRLKSII-EQSS 166
GITE+ G SS GK P GL +VYI TE P +RL+ ++ +Q
Sbjct: 101 GITELAGRSSAGKTQLALQLCLAVQFPRQHGGLEAGAVYICTEDAFPHKRLQQLMAQQPR 160
Query: 167 LFKDEGGDCLVSQK---KIFTVTCNDWANQEHVTTVQLPVLLERHPSIKLVIIDSISHHL 223
L D G+ L + +IF D ++PVLL R + +LV+IDS++
Sbjct: 161 LRTDVPGELLQKLRFGSQIFIEHVADVDTLLECVNKKVPVLLSRGMA-RLVVIDSVAAPF 219
Query: 224 RVELQSKTFQESRSNRYIIDSMAENLLSLAQKHNLAIVVANQVSDKL 270
R E S Q S + S+ L L+ ++ NQV++ +
Sbjct: 220 RCEFDS---QASAPRARHLQSLGATLRELSSAFQSPVLCINQVTEAM 263
>YER179w [DL] KOG1434 Meiotic recombination protein Dmc1
Length = 334
Score = 53.5 bits (127), Expect = 7e-07
Identities = 47/166 (28%), Positives = 72/166 (43%), Gaps = 16/166 (9%)
Query: 104 IYSKGITEIFGESSTGKXXXXXXXXXXXXXPEDMNGLNGQSVYITTEGDLPTRRLKSIIE 163
I + ITE+FGE GK P +M G G+ YI TEG R+K I E
Sbjct: 111 IMTMSITEVFGEFRCGKTQMSHTLCVTTQLPREMGGGEGKVAYIDTEGTFRPERIKQIAE 170
Query: 164 QSSLFKDEGGDCLVSQKKIFTVTCNDWANQEHVTTVQLPVLLERHPS---IKLVIIDSIS 220
L + CL + V+ N EH ++L L S +L+++DSI
Sbjct: 171 GYEL---DPESCLAN------VSYARALNSEH--QMELVEQLGEELSSGDYRLIVVDSIM 219
Query: 221 HHLRVELQSKTFQESRSNRYIIDSMAENLLSLAQKHNLAIVVANQV 266
+ RV+ + R + ++ L LA++ N+A+ + NQV
Sbjct: 220 ANFRVDYCGRGELSERQQK--LNQHLFKLNRLAEEFNVAVFLTNQV 263
>YER095w [L] KOG1433 DNA repair protein RAD51/RHP55
Length = 400
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/180 (24%), Positives = 70/180 (38%), Gaps = 12/180 (6%)
Query: 88 CFTTXXXXXXXXXXXXIYSKGITEIFGESSTGKXXXXXXXXXXXXXPEDMNGLNGQSVYI 147
C TT + + ITE+FGE TGK P D+ G G+ +YI
Sbjct: 159 CLTTGSKNLDTLLGGGVETGSITELFGEFRTGKSQLCHTLAVTCQIPLDIGGGEGKCLYI 218
Query: 148 TTEGDLPTRRLKSIIEQSSLFKDEGGDCLVSQKKIFTVTCNDWANQEH-VTTVQLPVLLE 206
TEG RL SI ++ L D+ + V N +H + + +
Sbjct: 219 DTEGTFRPVRLVSIAQRFGLDPDDA---------LNNVAYARAYNADHQLRLLDAAAQMM 269
Query: 207 RHPSIKLVIIDSISHHLRVELQSKTFQESRSNRYIIDSMAENLLSLAQKHNLAIVVANQV 266
L+++DS+ R + + E + + + L LA + +A+VV NQV
Sbjct: 270 SESRFSLIVVDSVMALYRTDFSGR--GELSARQMHLAKFMRALQRLADQFGVAVVVTNQV 327
>ECU11g0820 [L] KOG1433 DNA repair protein RAD51/RHP55
Length = 334
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/162 (25%), Positives = 73/162 (44%), Gaps = 12/162 (7%)
Query: 106 SKGITEIFGESSTGKXXXXXXXXXXXXXPEDMNGLNGQSVYITTEGDLPTRRLKSIIEQS 165
S ITEIFGE TGK P + G G+++YI TEG + RL I E+
Sbjct: 113 SGSITEIFGEFRTGKTQLCHTVAVTCQLPPEQGGGGGKAMYIDTEGTFRSERLVPIAERF 172
Query: 166 SLFKDEGGDCLVSQKKIFTVTCNDWANQEHVTTVQLPV-LLERHPSIKLVIIDSISHHLR 224
L +E D +S + + N +H + + + + ++IIDS + R
Sbjct: 173 GLDPNEVMD-NISYARAY--------NSDHQSQLLIKASAMMSESKYSVLIIDSATALYR 223
Query: 225 VELQSKTFQESRSNRYIIDSMAENLLSLAQKHNLAIVVANQV 266
+ + E + + + +L++LA+ +A+++ NQV
Sbjct: 224 TDFSGR--GELGARQLHLAKYLRSLVNLAETFRIAVIITNQV 263
>At3g22880 [DL] KOG1434 Meiotic recombination protein Dmc1
Length = 339
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/163 (25%), Positives = 71/163 (43%), Gaps = 10/163 (6%)
Query: 104 IYSKGITEIFGESSTGKXXXXXXXXXXXXXPEDMNGLNGQSVYITTEGDLPTRRLKSIIE 163
I + ITE FGE +GK P +M G NG+ YI TEG R+ I E
Sbjct: 123 IETSAITEAFGEFRSGKTQLAHTLCVTTQLPTNMKGGNGKVAYIDTEGTFRPDRIVPIAE 182
Query: 164 QSSLFKDEGGDCLVSQKKIFTVTCNDWANQEHVTTVQLPVLLERHPSIKLVIIDSISHHL 223
+ + D ++ + +T ++ + L + P +++I+DSI
Sbjct: 183 RFGMDPGAVLDNII-YARAYTY------EHQYNLLLGLAAKMSEEP-FRILIVDSIIALF 234
Query: 224 RVELQSKTFQESRSNRYIIDSMAENLLSLAQKHNLAIVVANQV 266
RV+ + R + + M L+ +A++ N+A+ + NQV
Sbjct: 235 RVDFTGRGELADRQQK--LAQMLSRLIKIAEEFNVAVYMTNQV 275
>Hs19924133 [L] KOG1433 DNA repair protein RAD51/RHP55
Length = 339
Score = 50.4 bits (119), Expect = 6e-06
Identities = 65/256 (25%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 22 LDAATFHGITCLDFLSQSPSNLMKTINRSINEIIKFQAA--------LRNEFELALADIK 73
L+ A FH + + + + +K I+ + + I +AA EF ++I
Sbjct: 41 LEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEI- 99
Query: 74 IQDITTLKEDDKPRCFTTXXXXXXXXXXXXIYSKGITEIFGESSTGKXXXXXXXXXXXXX 133
IQ T KE DK I + ITE+FGE TGK
Sbjct: 100 IQITTGSKELDK-------------LLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQL 146
Query: 134 PEDMNGLNGQSVYITTEGDLPTRRLKSIIEQSSLFKDEGGDCL--VSQKKIFTVTCNDWA 191
P D G G+++YI TEG RL ++ E+ L G D L V+ + F
Sbjct: 147 PIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL---SGSDVLDNVAYARAF-------- 195
Query: 192 NQEHVTTVQLPV-LLERHPSIKLVIIDSISHHLRVELQSKTFQESRSNRYIIDSMAENLL 250
N +H T + + L+I+DS + R + + E + + + LL
Sbjct: 196 NTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGR--GELSARQMHLARFLRMLL 253
Query: 251 SLAQKHNLAIVVANQV 266
LA + +A+V+ NQV
Sbjct: 254 RLADEFGVAVVITNQV 269
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.132 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,088,057
Number of Sequences: 60738
Number of extensions: 1040031
Number of successful extensions: 2737
Number of sequences better than 1.0e-05: 12
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2716
Number of HSP's gapped (non-prelim): 14
length of query: 480
length of database: 30,389,216
effective HSP length: 110
effective length of query: 370
effective length of database: 23,708,036
effective search space: 8771973320
effective search space used: 8771973320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)