ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV4545 good T KOG1981 Signal transduction mechanisms SOK1 kinase belonging to the STE20/SPS1/GC kinase family
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV4545 1565467 1562198 -1090
(1090 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR006c [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC k... 717 0.0
Hs8922999 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC... 89 5e-17
Hs8924256 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC... 82 4e-15
Hs22058715 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/G... 72 5e-12
7290648 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC k... 71 8e-12
CE03500 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC k... 62 6e-09
>YDR006c [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase family
Length = 901
Score = 717 bits (1851), Expect = 0.0
Identities = 379/675 (56%), Positives = 461/675 (68%), Gaps = 29/675 (4%)
Query: 428 KMRSFSVPTILHSSLRKMSSVAQH--EMMIPCKHNLPPA----------HLTLKHXXXXX 475
KMRS SVPTILHSSLRK+SS Q+ I H P H H
Sbjct: 240 KMRSHSVPTILHSSLRKLSSHNQYYRNQNILLNHPTPSGISKKKFSRNHHQPYLHSNNPL 299
Query: 476 XXXXXXXXXXXXXXXQPGGLVRKKRSLKKDQFSLRNAILMTHRLQTMDSK-DIPLEERIK 534
Q G + D + A MT++ S D+ LE+RI
Sbjct: 300 SSNPLSLKRAIFLNQQISG--NASTNANNDNINNSTATSMTNQSFLSSSNFDLTLEDRIN 357
Query: 535 YIKTYPTPIPLPPINLQCLKEIDLSEIVKNPQLRHDIVFDPMLQFRPNLDGERGIKKRQI 594
YIK PTP+P PPINLQ LKEIDL EI+KNPQLRHDI+FDP+LQFRPNLDGERG KKRQ+
Sbjct: 358 YIKATPTPVPFPPINLQGLKEIDLQEILKNPQLRHDIIFDPLLQFRPNLDGERGNKKRQL 417
Query: 595 ADKYWSDVENEIYVYNQRPDVFDENRSRLVPLFNTLKDVLVTIVPQKEVSTVANVLDTEL 654
A+ YW+DV+NEIYVY++RP++F NRSRLVPLF+TL+DVL+TIVPQKE + NVLDTEL
Sbjct: 418 ANIYWNDVQNEIYVYSKRPEIFQYNRSRLVPLFDTLRDVLLTIVPQKESPMINNVLDTEL 477
Query: 655 LIQELLKGSLVMSNFSDWLSQLFKHHCAPMRDPWVDKMSSKFKKAEENNSISTLVEALRL 714
IQELLKGSL+MSN S WL+ LFKHHCAPMRDPWVDKMS+KFK+AE ++S++ L+E LRL
Sbjct: 478 NIQELLKGSLIMSNLSGWLADLFKHHCAPMRDPWVDKMSNKFKEAERDSSLTRLIEGLRL 537
Query: 715 VFQILEAMKLDIANHQIRILRPALLSNTVDFEKQYFQSLLNSNRVDLKSSLKWFAEKYND 774
VFQILE MKLDIANHQIRILRPALLSN V+FEKQYF +L+ S RV+L +SL WF +K+N+
Sbjct: 538 VFQILETMKLDIANHQIRILRPALLSNAVEFEKQYFNTLIASKRVNLNTSLLWFDKKFNE 597
Query: 775 ACADNLIDPSKPTPIPKLYQVCIRSVISLLSCRKMVKEYPTALSFDHARLILLRADIRQI 834
L+ IP +Y +CIRS+I+LLSCRKMV+EYPT LSFDHARLILLRADIRQI
Sbjct: 598 NVTAGLVRNPSSITIPDVYNICIRSIINLLSCRKMVREYPTPLSFDHARLILLRADIRQI 657
Query: 835 VCLMVCKLLFKQLVANNADLTRPMKEFIIKNYTTKRLKEEIVSIITDEHGNCRWTKNTLS 894
VC++VC+LLF+QLVAN+ + + KE++I Y+TKRLK EI+SIITDEHGNCRWTKNT+S
Sbjct: 658 VCILVCRLLFQQLVANDPSMDKATKEYVIHTYSTKRLKNEIISIITDEHGNCRWTKNTMS 717
Query: 895 IAVQLNKVIDQLKEEYLRQYSDGTXXXXXXXXXXXXXXXXXXXXDHKKIDFATSWLSKQT 954
IAV L KVID L EY S D+ KI FA SWLSKQT
Sbjct: 718 IAVHLCKVIDDLHREYDNNGS-----------CEQARRPQLPSLDNSKITFAKSWLSKQT 766
Query: 955 QPLSDVYGVLEARVFKSLEEIVFKFGECSKDGTVKQDFINMCXXXXXXXXXXXXXXSTLP 1014
QPLS+VYGVLE RVFKSLE+ +F EC+ DG VKQDF+ + +T
Sbjct: 767 QPLSEVYGVLENRVFKSLEDAIFNRSECTIDGRVKQDFVYLYNTNNGNVGSTNTLSTT-- 824
Query: 1015 ISNDDSTGVSSIFQSPSEANRTSTSKKEMEIKESLAAIDMEEFENSYRHLYTVVNFHWSV 1074
++ S +S SPS+ + T+ + + + AA ++EEFEN YRHLY ++N HWSV
Sbjct: 825 -TDTASVKISPSLMSPSKTSTTTPTGNAIASRGLFAATELEEFENVYRHLYALINLHWSV 883
Query: 1075 FGCHYLEYMGDKVEK 1089
FG HY+E +GDKV K
Sbjct: 884 FGPHYIEMLGDKVNK 898
>Hs8922999 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase
family
Length = 509
Score = 88.6 bits (218), Expect = 5e-17
Identities = 82/364 (22%), Positives = 159/364 (43%), Gaps = 40/364 (10%)
Query: 522 MDSKDIPLEERIKYIKTYPT----PIPLPPINLQCLKEIDLSEIVKNPQLRHDIVFDPML 577
++ D L++ IK + P P PP + + ++ + V N L H+IV +
Sbjct: 29 VEGADEALQKAIKSDSSSPQRVQRPHSSPPRFVTVEELLETARGVTNMALAHEIVVNGDF 88
Query: 578 QFRPNLDGERGIKKR--QIADK-YWSDVENEIYVYNQRPDVFDENRSRLVPLFNTLKDVL 634
Q +P E +KKR +I K +W + ++ ++ P +D + L +K+ L
Sbjct: 89 QIKPVELPENSLKKRVKEIVHKAFWDCLSVQL---SEDPPAYDH----AIKLVGEIKETL 141
Query: 635 VTIVPQKEV---STVANVLDTELLIQELLKGSLVMSNFSDWLSQLFKHHCAPMRDPWVDK 691
++ + + + VLD +L+ QE G+L +S ++++ + CAP RD V K
Sbjct: 142 LSFLLPGHTRLRNQITEVLDLDLIKQEAENGALDISKLAEFIIGMMGTLCAPARDEEVKK 201
Query: 692 MSSKFKKAEENNSISTLVEALRLVFQILEAMKLDIANHQIRILRPALLSNTVDFEKQYFQ 751
+ I +V R +F +L+ MK+D+AN I +RP L+ +V++E++ FQ
Sbjct: 202 LKD----------IKEIVPLFREIFSVLDLMKVDMANFAISSIRPHLMQQSVEYERKKFQ 251
Query: 752 SLLNSNRVDLKSSLKWFAEKYNDACADNLID-------PSKPTPIPKLYQVCIR--SVIS 802
+L L +W E D + +P+L V ++ + +
Sbjct: 252 EILERQPNSLDFVTQWLEEASEDLMTQKYKHALPVGGMAAGSGDMPRLSPVAVQNYAYLK 311
Query: 803 LLSCRKMVKEYPTALSFDHARLILLRADIRQIVCLMVCKLLFKQL----VANNADLTRPM 858
LL + + +P + D +R L+ + Q+ L L+ + +++ AD +
Sbjct: 312 LLKWDHLQRPFPETVLMDQSRFHELQLQLEQLTILGAVLLVTFSMAAPGISSQADFAEKL 371
Query: 859 KEFI 862
K +
Sbjct: 372 KMIV 375
>Hs8924256 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase
family
Length = 441
Score = 82.4 bits (202), Expect = 4e-15
Identities = 83/338 (24%), Positives = 153/338 (44%), Gaps = 49/338 (14%)
Query: 588 GIKKRQIADKYWSDVENEIYVYNQRPDVFDENRSRLVPLFNTLKDVLVTIVPQKEVST-- 645
G K + + +W ++ ++ + P F S + L +K++L++++ ++
Sbjct: 20 GKVKETVHNAFWDHLKEQL---SATPPDF----SCALELLKEIKEILLSLLLPRQNRLRI 72
Query: 646 -VANVLDTELLIQELLKGSLVMSNFSDWLSQLFKHHCAPMRDPWVDKMSSKFKKAEENNS 704
+ LD +LL QE G+L + S ++ + CAP+RD V K+ +
Sbjct: 73 EIEEALDMDLLKQEAEHGALKVLYLSKYVLNMMALLCAPVRDEAVQKLEN---------- 122
Query: 705 ISTLVEALRLVFQILEAMKLDIANHQIRILRPALLSNTVDFEKQYFQSLLNSNRVDLKSS 764
I+ V LR +FQ+L MK+D+ N+ I+ L+P L +++ +E+ FQ LLN L +
Sbjct: 123 ITDPVWLLRGIFQVLGRMKMDMVNYTIQSLQPHLQEHSIQYERAKFQELLNKQPSLLNHT 182
Query: 765 LKWFAEKYND------ACAD-----NLIDPS------KPTPIPKLYQVCIRSVISLLSCR 807
KW + D C D ++ PS P P+ +C + ++LL
Sbjct: 183 TKWLTQAAGDLTMSPPTCPDTSDSSSVAGPSPNEAANNPEPLSPTMVLC-QGFLNLLLWD 241
Query: 808 KMVKEYPTALSFDHARLILLRADIRQIVCLMVCKLLFKQLVANNADLTRPMKEFIIKNYT 867
+E+P L D RL L++ + Q+ +M LL + + P +F+ K
Sbjct: 242 LENEEFPETLLMDRTRLQELKSQLHQLT-VMASVLLVASSFSGSVLFGSP--QFVDK--- 295
Query: 868 TKRLKEEIVSIITDEHGNCRWTKNTLSIAVQLNKVIDQ 905
LK S++ D H R + L+++ Q+++ I Q
Sbjct: 296 ---LKRITKSLLEDFHS--RPEEAILTVSEQVSQEIHQ 328
>Hs22058715 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase
family
Length = 274
Score = 72.0 bits (175), Expect = 5e-12
Identities = 49/213 (23%), Positives = 101/213 (47%), Gaps = 23/213 (10%)
Query: 562 VKNPQLRHDIVFDPMLQFRPNLDGERGIK---KRQIADKYWSDVENEIYVYNQRPDVFDE 618
+ N L H+I + Q + E+ + K + +W +++E+ N P F+
Sbjct: 72 LSNLTLAHEIAVNENFQLKQEALPEKSLAGRVKHIVHQAFWDVLDSEL---NADPPEFEH 128
Query: 619 NRSRLVPLFNTLKDVLVTIVP---QKEVSTVANVLDTELLIQELLKGSLVMSNFSDWLSQ 675
+ LF ++++L++ + + + + VLDT+L+ Q+ ++ + ++++
Sbjct: 129 ----AIKLFEEIREILLSFLTPGGNRLRNQICEVLDTDLIRQQAEHSAVDIQGLANYVIS 184
Query: 676 LFKHHCAPMRDPWVDKMSSKFKKAEENNSISTLVEALRLVFQILEAMKLDIANHQIRILR 735
CAP+RD E + +VE LR +F +L+ M++D+AN I LR
Sbjct: 185 TMGKLCAPVRD----------NDIRELKATGNIVEVLRQIFHVLDLMQMDMANFTIMSLR 234
Query: 736 PALLSNTVDFEKQYFQSLLNSNRVDLKSSLKWF 768
P L V++E+ FQ +L + S++++F
Sbjct: 235 PHLQRQLVEYERTKFQEILEETPRTVLSTIRFF 267
>7290648 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase
family
Length = 494
Score = 71.2 bits (173), Expect = 8e-12
Identities = 53/252 (21%), Positives = 115/252 (45%), Gaps = 25/252 (9%)
Query: 541 TPIPLPPINLQCLKEIDLSEI------VKNPQLRHDIVFDP---MLQFRPNLDGERGIKK 591
T LP ++ K + L E+ ++N +L H+I +P + ++ P D G K
Sbjct: 37 TRFVLPSLDGTPPKIVTLDEVSSMFKNLRNMELAHEIALNPDFKLQKYEPPSDSLEGAIK 96
Query: 592 RQIADKYWSDVENEIYVYNQRPDVFDENRSRLVPLFNTLKDVLVTIVPQKEVSTVANVLD 651
+ + +W + ++ +++P +D+ RL+ L++ ++ ++ + VLD
Sbjct: 97 KMVHKAFWDLLRVQL---DRQPPSYDQ-AIRLLAEIKECFPQLLSPNNERALAHINEVLD 152
Query: 652 TELLIQELLKGSLVMSNFSDWLSQLFKHHCAPMRDPWVDKMSSKFKKAEENNSISTLVEA 711
++ Q+ +G+L +++++ + C+P RD V + I +V+
Sbjct: 153 DSVIRQQAERGTLDFRAYANFVINILSRSCSPARDEAVAAL----------RKIDDVVDT 202
Query: 712 LRLVFQILEAMKLDIANHQIRILRPALLSNTVDFEKQYFQSLLNS--NRVDLKSSLKWFA 769
R + +++ MKLD+AN +R+ R + +N+V +EK+ F L V ++ W
Sbjct: 203 FRCILELMTLMKLDMANFMLRLARTEIAANSVQYEKEKFSKYLREFHGNVGFPATEDWLQ 262
Query: 770 EKYNDACADNLI 781
+ + D I
Sbjct: 263 RHRSGSSDDETI 274
>CE03500 [T] KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase
family
Length = 451
Score = 61.6 bits (148), Expect = 6e-09
Identities = 76/368 (20%), Positives = 152/368 (40%), Gaps = 46/368 (12%)
Query: 566 QLRHDIVFDPMLQF--RPNLDGERGIKKRQIADKYWSDVENEIYVYNQRPDVFDENRSRL 623
+L H+I DP Q +P +R +++ + Y++ + ++ + P + S L
Sbjct: 2 ELVHEIAIDPNFQIPDKPTNAIQRCVQE-SMHKAYYNQLRRDLA---KDPPELEYCFSFL 57
Query: 624 VPLFNTLKDVLVTIVPQKEVSTVANVLDTELLIQELLKGSLVMSNFSDWLSQLFKHHCAP 683
+ + + D ++T + + + ++LD L +L +G L + ++ L C+P
Sbjct: 58 MEVKTMILDDILTAQHTRLKAEINSMLDETALRGKLDQGQLDIKKVMKYIVDLCSRLCSP 117
Query: 684 MRDPWVDKMSSKFKKAEENNSISTLVEALRLVFQILEAMKLDIANHQIRILRPALLSNTV 743
RD V ++ ++ + +++ +LE MK D+ N+QI R A+ +
Sbjct: 118 ARDVKVAELRTR----------TDVIDIFEGTMDLLELMKNDLTNYQISQNRAAIEEYSS 167
Query: 744 DFEKQYFQSLLNSNRVDLKSSLKWFAEKYNDACADNLIDPSKPTPIPK----------LY 793
E FQ L N + +W Y++ L + T + K L
Sbjct: 168 KHEYDMFQKFLIENPNGCYFARQWLKAAYDELFEKKLDAEGEETSVKKERKNEDTDTVLI 227
Query: 794 QVCIRSVISLLSCRKMVKEYPTALSFDHARLILLRADIRQIV-----CLMVCKLLFKQLV 848
R L+ + +P L D ++ LL QIV + C + KQ +
Sbjct: 228 DTTSRGYTKLIQVNE-YDGFPETLKIDKIKIELLAEKFLQIVMCASSVFVTCNVAGKQ-I 285
Query: 849 ANNADLTRPMKEFII---KNYTTKRLKEEI---------VSIITDEHGNCRW-TKNTLSI 895
+ +AD + +K+ +I N +R+K ++ ++ T + N W T+++ SI
Sbjct: 286 SESADFKKTLKDHLIVITNNTDEERIKSDLEKIGEQCVKEAVDTSKKLNIEWNTESSTSI 345
Query: 896 AVQLNKVI 903
Q+N +I
Sbjct: 346 RNQINALI 353
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.132 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,267,316
Number of Sequences: 60738
Number of extensions: 1809032
Number of successful extensions: 4965
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 4954
Number of HSP's gapped (non-prelim): 8
length of query: 1090
length of database: 30,389,216
effective HSP length: 117
effective length of query: 973
effective length of database: 23,282,870
effective search space: 22654232510
effective search space used: 22654232510
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)