ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV4633 check: MH V KOG1826 Defense mechanisms Ras GTPase activating protein RasGAP/neurofibromin
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV4633 1596283 1587617 -2889
(2889 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOL081w [V] KOG1826 Ras GTPase activating protein RasGAP/neurofi... 1626 0.0
YBR140c [V] KOG1826 Ras GTPase activating protein RasGAP/neurofi... 1583 0.0
Hs4557793 [V] KOG1826 Ras GTPase activating protein RasGAP/neuro... 271 9e-72
7301417 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofi... 270 3e-71
Hs4759026 [T] KOG2059 Ras GTPase-activating protein 99 8e-20
7294865 [T] KOG2059 Ras GTPase-activating protein 81 3e-14
Hs12545410 [T] KOG2059 Ras GTPase-activating protein 80 4e-14
7293174 [R] KOG3508 GTPase-activating protein 77 3e-13
CE28277 [R] KOG3508 GTPase-activating protein 77 5e-13
CE23475 [R] KOG3508 GTPase-activating protein 77 5e-13
CE23474 [R] KOG3508 GTPase-activating protein 77 5e-13
CE23473 [R] KOG3508 GTPase-activating protein 77 5e-13
CE23472 [R] KOG3508 GTPase-activating protein 77 5e-13
CE23471 [R] KOG3508 GTPase-activating protein 77 5e-13
CE23470 [R] KOG3508 GTPase-activating protein 77 5e-13
Hs4506431 [R] KOG3508 GTPase-activating protein 72 2e-11
Hs12545406 [R] KOG3508 GTPase-activating protein 72 2e-11
Hs22060041 [R] KOG3508 GTPase-activating protein 70 5e-11
Hs20070109 [R] KOG3508 GTPase-activating protein 70 5e-11
Hs12545408 [T] KOG2059 Ras GTPase-activating protein 69 1e-10
SPBC646.12c [T] KOG2128 Ras GTPase-activating protein family - I... 67 6e-10
Hs20546119 [R] KOG3508 GTPase-activating protein 66 9e-10
7293383 [R] KOG3508 GTPase-activating protein 65 2e-09
Hs5901958 [T] KOG2059 Ras GTPase-activating protein 64 4e-09
Hs4758808 [R] KOG3508 GTPase-activating protein 64 5e-09
Hs4506787 [T] KOG2128 Ras GTPase-activating protein family - IQGAP 59 9e-08
Hs5729887 [T] KOG2128 Ras GTPase-activating protein family - IQGAP 57 3e-07
>YOL081w [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 3079
Score = 1626 bits (4210), Expect = 0.0
Identities = 921/2531 (36%), Positives = 1443/2531 (56%), Gaps = 93/2531 (3%)
Query: 417 DDTEDMTRVSVLTFATLMLMLSPDIFEEINNTSLKNIPDDALGTDEXXXXXXXXXXXXXX 476
DDTE + SVL F T + M D+F E+N TS K IPD + +
Sbjct: 581 DDTEVLPHTSVLKFLTTLTMFDIDLFNELNATSFKYIPDCTMHRPKERTSSFNNTAHETG 640
Query: 477 XXXXXXXXXXXXXXXXKFGLKKIRNQLTSLNHVTNKKTKFLLTILKNINGNNIISEYSIL 536
GLKK LTSL T K KF+ +L+N+NGN +S+ ++L
Sbjct: 641 SEKTSGIKHITQ------GLKK----LTSLPSSTKKTVKFVKMLLRNLNGNQAVSDVALL 690
Query: 537 DTLRVLILISKLSTSPLLREADSSVSYFTRRLFFLMCDLLQLGSEKDAKRNPMVAHCLAK 596
DT+R L+ ++++ L + + F +RL +M L +G + ++K N + CL K
Sbjct: 691 DTMRALLSFFTMTSAVFLVDRNLPSVLFAKRLIPIMGTNLSVGQDWNSKINNSLMVCLKK 750
Query: 597 FPQSHFKLQVDYFYVACSLDADAFLEKLSDFIKRKHSGISHIRMITDGFCIYFNNATMHN 656
+ +LQ+ +F A D + L +LS + + + + T+GF I+F+ +
Sbjct: 751 NSTTFVQLQLIFFSSAIQFDHELLLARLSIDTMANNLNMQKLCLYTEGFRIFFDIPSKKE 810
Query: 657 TKDRIMTRIDDFLKDTACEMANILLSESNLFDEHASEVVDSIF------ELKPGDYSKGY 710
+ I +I F K +A+ILL E FDE +++V SI E + KG
Sbjct: 811 LRKAIAVKISKFFKTLFSIIADILLQEFPYFDEQITDIVASILDGTIINEYGTKKHFKGS 870
Query: 711 QK--IQFNASPLPSSSPAFMNFFSRTG---DXXXXXXXXXXXXXXXXXPVEGVSAAIAGK 765
S S+S + M S G D S + K
Sbjct: 871 SPSLCSTTRSRSGSTSQSSMTPVSPLGLDTDICPMNTLSLVGSSTSRNSDNVNSLNSSPK 930
Query: 766 NLRD------IVAPTARRPSKSSFASLRET-----SSPNEGEKSTNTIRTIIDKNIKSPL 814
NL +VAP AR + +R +SP EKS+ R + +P+
Sbjct: 931 NLSSDPYLSHLVAPRARHALGGPSSIIRNKIPTTLTSPPGTEKSSPVQRPQTESISATPM 990
Query: 815 RVGSML------------------RKTSQESISSATVKNIRDTLERH------EQETTQS 850
+ + R+ S ES+ +K+ + ++ H + T Q
Sbjct: 991 AITNSTPLSSAAFGIRSPLQKIRTRRYSDESLGKF-MKSTNNYIQEHLIPKDLNEATLQD 1049
Query: 851 ARIILINIFSIYKGMTRYYYMTYDEDSDTTVYLRDFNRTIKPVFASLVDDNESLFDTARG 910
AR I+INIFSI+K Y+ + ++ +S+ +DF +KP+F ++V + L +TA+
Sbjct: 1050 ARRIMINIFSIFKRPNSYFIIPHNINSNLQWVSQDFRNIMKPIFVAIVSPDVDLQNTAQS 1109
Query: 911 IISSVITQL-----KEPQVDITAFRSVCYVGSAYLLSLMGTTLFDLNLSDLKREQLLKPL 965
+ ++++ + + + I + +C +Y ++L LFDL +++ KR+ LL
Sbjct: 1110 FMDTLLSNVITYGESDENISIEGYHLLC----SYTVTLFAMGLFDLKINNEKRQILLDIT 1165
Query: 966 VDLWTARIGIAKTYEMNXXXXXXXXXXALTFHLIRGSVGRALFCSLYSNNTAIHKLLKTA 1025
V R +A E + LTF LI G+VGRALF SLYS+ I K LK A
Sbjct: 1166 VKFMKVRSHLAGIAEASHHMEYISDSEKLTFPLIMGTVGRALFVSLYSSQQKIEKTLKIA 1225
Query: 1026 FKLFTEEIRIHQXXXXXXXXXXXXXXXXXFANVEFFQVMCRDNYVSTGVVAFQRRLRTDI 1085
+ + I H+ N+EF + MC DNY ++G +AFQRR R +I
Sbjct: 1226 YTEYLSAINFHERNIDDADKTWVH-------NIEFVEAMCHDNYTTSGSIAFQRRTRNNI 1278
Query: 1086 LKYIKFPDKIVFDVSHLIYKRWYDASLKPSLSTSETSHFRNYAGFLAASCGIFSTINDST 1145
L++ P+ I+ D +IYK+W+ + SL E + FRN+AG LA+ GI
Sbjct: 1279 LRFATIPNAILLDSMRMIYKKWHTYTHSKSLEKQERNDFRNFAGILASLSGILFINKKIL 1338
Query: 1146 QHHFPLLHEMKKSVEAKVSYFVGKQCSWLNNEDLLTRENSKDILATELHPLAFDALFAAL 1205
Q +P L + ++ + F+ KQC WLN DLLTRENS+DIL+ ELHPL+F+ LF L
Sbjct: 1339 QEMYPYLLDTVSELKKNIDSFISKQCQWLNYPDLLTRENSRDILSVELHPLSFNLLFNNL 1398
Query: 1206 RQRIDELKDINIVEKDNELSFILLEQVIMVVRMILERDDTSEVLIIVSLPLLNLIDDILR 1265
R ++ EL ++ +NE S++LLEQ+I ++R IL RDD + V+++ S +++LID +
Sbjct: 1399 RLKLKELACSDLSIPENESSYVLLEQIIKMLRTILGRDDDNYVMMLFSTEIVDLIDLLTD 1458
Query: 1266 IVDTIDKSSPKYFKCVIHLSKMLKSFQHSESSICIAGYMVVKNRWLRLVTQWFQSAIFKE 1325
+ I PKY K +I ++KM + QHSE ++ + + VKN+WLR +T WFQ +I +E
Sbjct: 1459 EIKKIPAYCPKYLKAIIQMTKMFSALQHSEVNLGVKNHFHVKNKWLRQITDWFQVSIARE 1518
Query: 1326 FDLLNLSKSHRDMDLEKRDMDYLYIDTTIESSKAIAYLTKDLVLEAPQSMSEIELQRSKS 1385
+D NLSK ++MDL KRDMD LYIDT IE+S AIAYLT+ LE P + S+ EL RS+S
Sbjct: 1519 YDFENLSKPLKEMDLVKRDMDILYIDTAIEASTAIAYLTRHTFLEIPPAASDPELSRSRS 1578
Query: 1386 VVFGNYFNILLKALEKSTNVENFPSTLRHKIASLNENIIISLTNLLIANVDVGLNHATPI 1445
V+FG YFNIL+K LEKS++ +N+P LRHK++ LN+N+I+SLTNL NVD L P+
Sbjct: 1579 VIFGFYFNILMKGLEKSSDRDNYPVFLRHKMSVLNDNVILSLTNLSNTNVDASLQFTLPM 1638
Query: 1446 GYSNNRNIRLAFMNVFVNIVSSFDISNNRTKRKRDEIVEEVVLMTLKRPTLLSKACRICP 1505
GYS NRNIR AF+ VF+NIV+++ +T + E ++ + T++ P L S +CP
Sbjct: 1639 GYSGNRNIRNAFLEVFINIVTNYRTYTAKTDLGKLEAADKFLRYTIEHPQLSSFGAAVCP 1698
Query: 1506 ASDIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLK 1565
ASDIDA A+ ++ F+ +NA HI+V +L++ EI ++R +ILRRNSCATR+LSMLAR K
Sbjct: 1699 ASDIDAYAAGLINAFETRNATHIVVAQLIKNEIEKSSRPTDILRRNSCATRSLSMLARSK 1758
Query: 1566 GMDYLSNILKPILEELINSKECFDVEKLDPNDVDAPRNLMLFKKYMTKVVDAITGSVDSF 1625
G +YL L+P+L+++I +++ F++EKL P D DA R + LF KYM +++++I+ SV F
Sbjct: 1759 GNEYLIRTLQPLLKKIIQNRDFFEIEKLKPEDSDAERQIELFVKYMNELLESISNSVSYF 1818
Query: 1626 PPQFFVICQAIHSSASERFPEYADIAVGSFLFLRFFCPALVSPDSEEIVDSLTPKARKSS 1685
PP F ICQ I+ A E+FP++A IA GSF+FLRFFCPALVSPDSE I+D +++
Sbjct: 1819 PPPLFYICQNIYKVACEKFPDHAIIAAGSFVFLRFFCPALVSPDSENIIDISHLSEKRTF 1878
Query: 1686 MSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNRKVKINLRMQNR 1745
+SLAKVIQNIANGS N +W L S+ +FLK CS++IF FL+ + +R + I +R
Sbjct: 1879 ISLAKVIQNIANGSENFSRWPALCSQKDFLKECSDRIFRFLAELCRTDRTIDIQVRTDPT 1938
Query: 1746 VLPNEFSFLHKFLYYHGLEMRNALIEDIK----SFDDLATVRETAEAVDELLSLMGQPRM 1801
+ ++ FLH F+Y +GLE+R ++ + K D + T +D++L +GQP+M
Sbjct: 1939 PIAFDYQFLHSFVYLYGLEVRRNVLNEAKHDDGDIDGDDFYKTTFLLIDDVLGQLGQPKM 1998
Query: 1802 EFKNEIPAYIREHSETSSELYEFMIKQAVKCPETPENECKFVQESVTSEGLPVVIFNWCE 1861
EF NEIP YIREH + ELYEFM + A + ET V ES +SEG+P++
Sbjct: 1999 EFSNEIPIYIREHMDDYPELYEFMNRHAFRNIETSTAYSPSVHESTSSEGIPIITLTMSN 2058
Query: 1862 YQKDGNDDVETLIYLIFQIYSKVMTKKHFFVTDCTGFDGVRQPKNRFVKLSSLFFNLIPA 1921
+ D + D++T+ Y QIY+++ T KH + DCT FD +F+ SL L+P
Sbjct: 2059 F-SDRHVDIDTVAYKFLQIYARIWTTKHCLIIDCTEFDEGGLDMRKFI---SLVMGLLPE 2114
Query: 1922 EGLANCETFYFFNPTPIYLEWWTEFQNSHANIFQNMNVSMSFLNTDSDPKLIKALGLSDY 1981
NC Y+FN +++ + + + N++ + + F+N++SD L+K++G++
Sbjct: 2115 VAPKNCIGCYYFNVNETFMDNYGKCLDKD-NVYVSSKIPHYFINSNSDEGLMKSVGITGQ 2173
Query: 1982 SKEVYHDVRVTLHDVSLYDEAKRQFSPVTLKVGNKYFQIVHDSAWTLKASDASDTIVINP 2041
+V D+RV+LHD++LYDE + +F+PV+LK+G+ YFQ++H++ K D +
Sbjct: 2174 GLKVLQDIRVSLHDITLYDEKRNRFTPVSLKIGDIYFQVLHETPRQYKIRDMGTLFDVKF 2233
Query: 2042 NDVYEIAEVASTSVSRITGVSSEFCFELRNRKRLIMSSPKYLEILKMFYYSQAKILEEFN 2101
NDVYEI+ + VS ITGV++EF ++ +RLI SSPKYLEI+KMFYY+Q ++ E+
Sbjct: 2234 NDVYEISRIFEVHVSSITGVAAEFTVTFQDERRLIFSSPKYLEIVKMFYYAQIRLESEYE 2293
Query: 2102 DNEYSDISSRHS----KEAIKTADIVSHXXXXXXXXXXXDD-EIRVVSYNLLSSMHTTFS 2156
+ S SS +S K+ + ++ H + +++ SYNL+++ +F
Sbjct: 2294 MDNNSSTSSPNSNNKDKQQKERTKLLCHLLLVSLIGLFDESKKMKNSSYNLIAATEASFG 2353
Query: 2157 LNMGHLLPKTPDIYISEDPNPIFEPLIKTLAETSPELTSYYLKYSIDLLENGEHDLHFIA 2216
LN G ++P++Y+ ED + K+LAE++PELT+Y Y ++ L+N +I
Sbjct: 2354 LNFGSHFHRSPEVYVPEDTTTFLGVIGKSLAESNPELTAYMFIYVLEALKNNVIPHVYIP 2413
Query: 2217 NLLRTMRYWAKNLSKHVFLADDQKGPEIATKLVRRLVKLTVQQNQPTSLYLDYIWPVLVH 2276
+ + + YW NL +HV+LADD++GPE + + R L++L+V++ ++Y+ Y+W +L+
Sbjct: 2414 HTICGLSYWIPNLYQHVYLADDEEGPENISHIFRILIRLSVRETDFKAVYMQYVWLLLLD 2473
Query: 2277 DSCLLKEVIEEVVGHCMDRAAEGVDWHPACKILLRAPTIDITGVIIKRVIDITHSFLPNL 2336
D L +++EV+ H ++R +E DW +L PT ++ II++++ SFLP+L
Sbjct: 2474 DGRLTDIIVDEVINHALERDSENRDWKKTISLLTVLPTTEVANNIIQKILAKIRSFLPSL 2533
Query: 2337 KEETNVNSWTELIILVHLCSSLFCDSPLLVDIYMPEVLYIVSLLIDVGSTEMRLSLHKLL 2396
K E SW+EL ILV + +F ++ LLV +Y+PE+L+IVSLLIDVG E+R SLH+LL
Sbjct: 2534 KLEAMTQSWSELTILVKISIHVFFETSLLVQMYLPEILFIVSLLIDVGPRELRSSLHQLL 2593
Query: 2397 MNACQSLLSNASLPKYNRRNLYEIQKIFSDQKMKIMFGFSQERGRVLQNFSASSFLTKFT 2456
MN C SL N++LP+ +R NL EI IF+ QK+K MFGFS+++GR+LQ FSASSF +KF
Sbjct: 2594 MNVCHSLAINSALPQDHRNNLDEISDIFAHQKVKFMFGFSEDKGRILQIFSASSFASKFN 2653
Query: 2457 TLEHFVNNLMSLMDNGSLINVEQWKTRYMQYIMGTVFHVQSFLSARAMMILGIVSKEGIS 2516
L+ F+NN++ LM+ S WKTRY +Y++ +VF SFLSAR++MI+GI+ K I+
Sbjct: 2654 ILDFFINNILLLMEYSSTYEANVWKTRYKKYVLESVFTSNSFLSARSIMIVGIMGKSYIT 2713
Query: 2517 DGLLLNLLRQSMVIVAMPDVNDEQIFFVISTFFTYTKAVIGVDPQSPLLPKLFWLASSIS 2576
+GL +L ++M ++A P + DE +F IS FTY+K V G+DP L+ LFW ++
Sbjct: 2714 EGLCKAMLIETMKVIAEPKITDEHLFLAISHIFTYSKIVEGLDPNLDLMKHLFWFSTLFL 2773
Query: 2577 FSINMMIYQSGLLFMSSTAQHLSLGSMEKMDRGEIPEPLIKQLMAQRNFGENILRQVEAM 2636
S + +I++ LLF+S+ + L + E E LI L+ R F L ++E +
Sbjct: 2774 ESRHPIIFEGALLFVSNCIRRLYMAQFE----NESETSLISTLLKGRKFAHTFLSKIENL 2829
Query: 2637 GDLRVTESNFSHVMISLICKGLLIPYTRATSLSSLVVFFKLFYFELMFGPNED-YLIFMF 2695
+ E NF+H++I +I KGL P+ ++T+ L + F+ YFE D YL +MF
Sbjct: 2830 SGIVWNEDNFTHILIFIINKGLSNPFIKSTAFDFLKMMFRNSYFEHQINQKSDHYLCYMF 2889
Query: 2696 FIFILQRPSAFLKCMEDVDMDTDVVQLDDRNKIHKSLLDWLVKFSPDACLTMYKASLYFS 2755
++ + + F + + DVD + ++V ++++N I K LL+WL + +A +T+Y+ ++ F
Sbjct: 2890 LLYFVLNCNQFEELLGDVDFEGEMVNIENKNTIPKILLEWLSSDNENANITLYQGAILFK 2949
Query: 2756 CKATDEQGKVRFMLVYRHLMQHNLKAAFKLYPFVLNELRRLSKYSNNSSTVLLSFEIIKM 2815
C TDE + RF L+ RHL+ A + Y + NE+R++S + NS V L+F+I+ +
Sbjct: 2950 CSVTDEPSRFRFALIIRHLLTKKPICALRFYSVIRNEIRKISAFEQNSDCVPLAFDILNL 3009
Query: 2816 AVKSKEYLKLPMIEKEMYKKLEERGLTGIKSIPFENELANDVLTGVRENPIITYERKKLA 2875
V E L + +E ++L +RGL+ + S + +D++ + P YERK++
Sbjct: 3010 LVTHSESNSLEKLHEESIERLTKRGLSIVTSSGIFAK-NSDMMIPLDVKPEDIYERKRIM 3068
Query: 2876 VMLLSKVISSA 2886
M+LS++ SA
Sbjct: 3069 TMILSRMSCSA 3079
Score = 144 bits (362), Expect = 3e-33
Identities = 97/393 (24%), Positives = 190/393 (47%), Gaps = 43/393 (10%)
Query: 9 TDVTAFLLSQLDPLLPVNSHVKTFEEVERDPYFTNIRLSLFNLVVSHGYSAISPAIVAKL 68
T V L ++ P+LPV S++ T+ EVE F + R L N+ VS +A+ + +
Sbjct: 24 TLVNHILFERILPILPVESNLSTYSEVEEYSSFISCRSVLINVTVSRDANAMVEGTLELI 83
Query: 69 EQIA---NLSKDKNQDFDILLTLVVLLRMFTDTSEIYWRNLDPEY--------------- 110
E + + DK D++ +++++LR+ +D E W+N + +
Sbjct: 84 ESLLQGHEIISDKGSS-DVIESILIILRLLSDALEYNWQNQESLHYNDISTHVEHDQEQK 142
Query: 111 ---KLNYSLSDDSAFSRFYNGYSVQMASLHTIRPKPLSPQIANSFLQLLSRIKSNKRVIK 167
KLN L D S S NG H +P+ L P++A+ L+ +++K N R ++
Sbjct: 143 YRPKLNSILPDYS--STHSNG---NKHFFHQSKPQALIPELASKLLESCAKLKFNTRTLQ 197
Query: 168 MLNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYYTYLVDVLDQHCAYLFKYIAASNPH 227
+L + ++D ++ +++AASNP
Sbjct: 198 ILQNMISHVHGNILTTLSSSILPRHKSYLTRHN--HPSHCKMIDSTLGHILRFVAASNPS 255
Query: 228 EFHSFIRSVIITPLLVAHTHTES-----------EIAPYLCYFSFHYITSETLPSFLDVL 276
E+ FIR + P+ HTH+ S I P+ FSF Y++ +L+++
Sbjct: 256 EYFEFIRKSVQVPVTQTHTHSHSHSHSLPSSVYNSIVPHFDLFSFIYLSKHNFKKYLELI 315
Query: 277 QRMVVRMKKSIHQEILLYFASESIQSWIMARPHDYLRVIEGLQKNSSDPALQNIQKISTS 336
+ + V ++K+I+ +LL++++++I WIMARP +Y + L+ N+++ + +++ ++ +
Sbjct: 316 KNLSVTLRKTIYHCLLLHYSAKAIMFWIMARPAEYYELFNLLKDNNNEHS-KSLNTLNHT 374
Query: 337 LFEDVFSSFNIERILT--EGAISSATSPTVISP 367
LFE++ S+FN+ ++T + A ++SP+ SP
Sbjct: 375 LFEEIHSTFNVNSMITTNQNAHQGSSSPSSSSP 407
>YBR140c [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 3092
Score = 1583 bits (4100), Expect = 0.0
Identities = 924/2575 (35%), Positives = 1460/2575 (55%), Gaps = 159/2575 (6%)
Query: 419 TEDMTRVSVLTFATLMLMLSPDIFEEINNTSLKNIPDDALGTDEXXXXXXXXXXXXXXXX 478
+E + ++L F ++ +L ++++E+N+ S + I + + +
Sbjct: 569 SELSSHTAILRFLVVLTLLDSEVYDEMNSNSYRKISEPIMNINPKDSNTSSWGSASKNPS 628
Query: 479 XXXXXXXXXXXXXXKFGLKKIRNQLTSLNHVTNKKTKFLLTILKNINGNNIISEYSILDT 538
GLKK+ +L + KFL +++N+NG +S+ S++D+
Sbjct: 629 IRHLTH----------GLKKL-----TLQQGRKRNVKFLTYLIRNLNGGQFVSDVSLIDS 673
Query: 539 LRVLILISKLSTSPLLREADSSVS--YFTRRLFFLMCDLLQLGSE-KDAKRNPMVAHCLA 595
+R ++ + +++S + + DS+++ F++R + L+ L++G+ A N ++HC+
Sbjct: 674 IRSILFLMTMTSS--ISQIDSNIASVIFSKRFYNLLGQNLEVGTNWNSATANTFISHCVE 731
Query: 596 KFPQSHFKLQVDYFYVACSLDADAFLEKLSDFIKRKHSGISHIRMITDGFCIYFNNATMH 655
+ P +H +LQ+++F LD+D FL L + H + I + T+GF ++F+ +
Sbjct: 732 RNPLTHRRLQLEFFASGLQLDSDLFLRHLQLEKELNHIDLPKISLYTEGFRVFFHLVSTK 791
Query: 656 NTKDRIMTRIDDFLKDTACEMANILLSESNLFDEHASEVVDSIFELKPGDYSKGYQKIQF 715
+ I + LK C +A+ILL + FD++ ++++ SI + G+ QF
Sbjct: 792 KLHEDIAEKTSSVLKRLFCIIADILLKATPYFDDNVTKIIASILD--------GHILDQF 843
Query: 716 NASPLPS-----SSPAFMNFFSRTGDXXXXXXXXXXXXXXXXXPVEGVSAA-IAGKNLRD 769
+A+ S S A + ++ + P+ S + I D
Sbjct: 844 DAARTLSNDDHVSFDAATSVYTEPTEIIHNSSDASLVSSLSQSPLSINSGSNITNTRTWD 903
Query: 770 I--VAPTARRPSKSSFASL-----------------------------RETSSPNEGEKS 798
I + PT S +S SL + +SPN+ E+S
Sbjct: 904 IQSILPTLSNRSSASDLSLSNILTNPLEAQQNNNANLLAHRLSGVPTTKRYASPNDSERS 963
Query: 799 TNTIRT----IIDKNIKSPLRVGSMLRKTSQESISSAT---VKNIRD------------- 838
+ + + ++ SPL V S S +AT +KNI+
Sbjct: 964 RQSPYSSPPQLQQSDLPSPLSVLSSSAGFSSNHSITATPTILKNIKSPKPNKTKKIADDK 1023
Query: 839 -----TLERHEQETTQSARIILINIFSIYKGMTRYYYMTYDEDSDTTVYLRDFNRTIKPV 893
+ R AR I++NIFSI+K MT ++ T + + F IKP+
Sbjct: 1024 QLKQPSYSRVILSDNDEARKIMMNIFSIFKRMTNWFI----RPDANTEFPKTFTDIIKPL 1079
Query: 894 FASLVDDNESLFDTARGIIS---SVITQLKEPQVDITA-FRSVCYVGSAYLLSLMGTTLF 949
F S++D N+ L TAR I S I ++ D+ + Y+ Y ++L ++LF
Sbjct: 1080 FVSILDSNQRLQVTARAFIEIPLSYIATFEDIDNDLDPRVLNDHYLLCTYAVTLFASSLF 1139
Query: 950 DLNLSDLKREQLLKPLVDLWTARIGIAKTYEMNXXXXXXXXXXALTFHLIRGSVGRALFC 1009
DL L + KRE LL +V R ++ E + LT L+ G+VG +F
Sbjct: 1140 DLKLENAKREMLLDIIVKFQRVRSYLSNLAEKHNLVQAIITTERLTLPLLVGAVGSGIFI 1199
Query: 1010 SLYSNNTAIHKLLKTAFKLFTEEIRIHQXXXXXXXXXXXXXXXXXFANVEFFQVMCRDNY 1069
SLY + +L+K + F +R +Q N++F M +DN+
Sbjct: 1200 SLYCSRGNTPRLIKISCCEFLRSLRFYQKYVGALDQYSIY-------NIDFIDAMAQDNF 1252
Query: 1070 VSTGVVAFQRRLRTDILKYIKFPDKIVFDVSHLIYKRWYDASLKPSLSTSETSHFRNYAG 1129
++G VA QRRLR +IL YIK D I+ D +IYK+W+ S S++ E FR+ AG
Sbjct: 1253 TASGSVALQRRLRNNILTYIKGSDSILLDSMDVIYKKWFYFSCSKSVTQEELVDFRSLAG 1312
Query: 1130 FLAASCGIFSTIND------------------STQHHFPLLHEMKKSVEAKVSYFVGKQC 1171
LA+ GI S + + S + + +K + K+++F+ KQC
Sbjct: 1313 ILASMSGILSDMQELEKSKSAPDNEGDSLSFESRNPAYEVHKSLKLELTKKMNFFISKQC 1372
Query: 1172 SWLNNEDLLTRENSKDILATELHPLAFDALFAALRQRIDELKDINIVEKDNELSFILLEQ 1231
WLNN +LLTRENS+DIL+ ELHPL+F+ LF L +IDEL I++ + + SF+LLEQ
Sbjct: 1373 QWLNNPNLLTRENSRDILSIELHPLSFNLLFNNLGLKIDELMSIDLSKSHEDSSFVLLEQ 1432
Query: 1232 VIMVVRMILERDDTSEVLIIVSLPLLNLIDDILRIVDTIDKSSPKYFKCVIHLSKMLKSF 1291
+I+++R IL+RDD +++++ S LL+ +D ++ IV+ I S KY+K +I +SKM ++F
Sbjct: 1433 IIIIIRTILKRDDDEKIMLLFSTDLLDAVDKLIEIVEKISIKSSKYYKGIIQMSKMFRAF 1492
Query: 1292 QHSESSICIAGYMVVKNRWLRLVTQWFQSAIFKEFDLLNLSKSHRDMDLEKRDMDYLYID 1351
+HSE ++ I+ + +KN+WL+LV WF+ +I K++D NLS+ R+MDL+KRD D+LYID
Sbjct: 1493 EHSEKNLGISNHFHLKNKWLKLVIGWFKLSINKDYDFENLSRPLREMDLQKRDEDFLYID 1552
Query: 1352 TTIESSKAIAYLTKDLVLEAPQSMSEIELQRSKSVVFGNYFNILLKALEKSTNVENFPST 1411
T+IES+KA+AYLT ++ LE P S S+ + RS +V FGN+F ILLK LEKS ++ FP +
Sbjct: 1553 TSIESAKALAYLTHNVPLEIPPSSSKEDWNRSSTVSFGNHFTILLKGLEKSADLNQFPVS 1612
Query: 1412 LRHKIASLNENIIISLTNLLIANVDVGLNHATPIGYSNNRNIRLAFMNVFVNIVSSFDIS 1471
LRHKI+ LNEN+II+LTNL ANV+V L P+GYS N++IR+AF+ VF++IV+++ ++
Sbjct: 1613 LRHKISILNENVIIALTNLSNANVNVSLKFTLPMGYSPNKDIRIAFLRVFIDIVTNYPVN 1672
Query: 1472 NNRTKRKRDEIVEEVVLMTLKRPTLLSKACRICPASDIDALASSIVYFFDVKNAAHIIVT 1531
+ + + +++ + +K P L C +D+D A + FD +NA+HI+VT
Sbjct: 1673 PEKHEMDKMLAIDDFLKYIIKNPILAFFGSLACSPADVDLYAGGFLNAFDTRNASHILVT 1732
Query: 1532 ELVREEIGNATRHMEILRRNSCATRALSMLARLKGMDYLSNILKPILEELINSKECFDVE 1591
EL+++EI A R +ILRRNSCATRALS+ R +G YL L+P+L+ ++++KE F+++
Sbjct: 1733 ELLKQEIKRAARSDDILRRNSCATRALSLYTRSRGNKYLIKTLRPVLQGIVDNKESFEID 1792
Query: 1592 KLDPNDVDAPRNLMLFKKYMTKVVDAITGSVDSFPPQFFVICQAIHSSASERFPEYADIA 1651
K+ P ++ + L LF+KYMT+++DAIT S+D FP + IC+ I+++AS FPEYA IA
Sbjct: 1793 KMKPGSENSEKMLDLFEKYMTRLIDAITSSIDDFPIELVDICKTIYNAASVNFPEYAYIA 1852
Query: 1652 VGSFLFLRFFCPALVSPDSEEIVDSLTPKARKSSMSLAKVIQNIANGSVNSIKWKILESE 1711
VGSF+FLRF PALVSPDSE I+ RK ++LAKVIQ++ANG N K IL S+
Sbjct: 1853 VGSFVFLRFIGPALVSPDSENIIIVTHAHDRKPFITLAKVIQSLANGRENIFKKDILVSK 1912
Query: 1712 SEFLKNCSNKIFEFLS-VVSDKNRKVKINLRMQNRVLPNEFSFLHKFLYYHGLEMRNALI 1770
EFLK CS+KIF FLS + +N+R + ++SFLHKF Y + +R +I
Sbjct: 1913 EEFLKTCSDKIFNFLSELCKIPTNNFTVNVREDPTPISFDYSFLHKFFYLNEFTIRKEII 1972
Query: 1771 EDIKSFDDLATVRETAEAVDELLSLMGQPRMEFKNEIPAYIREHSETSSELYEFMIKQAV 1830
+ K + + ++ T D++L ++GQP ME KNEIP ++ E+ E LYEFM + A
Sbjct: 1973 NESKLPGEFSFLKNTVMLNDKILGVLGQPSMEIKNEIPPFVVENREKYPSLYEFMSRYAF 2032
Query: 1831 K---CPETPENECKFVQESVTSEGLPVVI--FNWCEYQKDGNDDVETLIYLIFQIYSKVM 1885
K E E+ FV E++T +G+ +++ F CEY N +++L+Y + QIY+++
Sbjct: 2033 KKVDMKEEEEDNAPFVHEAMTLDGIQIIVVTFTNCEY---NNFVMDSLVYKVLQIYARMW 2089
Query: 1886 TKKHFFVTDCTGFDGVRQPKNRFVKLSSLFFNLIPAEGLANCETFYFFNPTPIYLEWWTE 1945
KH+ V DCT F G K F KL++LFF+LIP + +NC Y+FN +++ W
Sbjct: 2090 CSKHYVVIDCTTFYG---GKANFQKLTTLFFSLIPEQASSNCMGCYYFNVNKSFMDQWAS 2146
Query: 1946 FQNSHANIFQNMNVSMSFLNTDSDPKLIKALGLSDYSKEVYHDVRVTLHDVSLYDEAKRQ 2005
+ N + + F+N+++D LIK+LGLS S EV DVRVTLHD++LYD+ K++
Sbjct: 2147 -SYTVENPYLVTTIPRCFINSNTDQSLIKSLGLSGRSLEVLKDVRVTLHDITLYDKEKKK 2205
Query: 2006 FSPVTLKVGNKYFQIVHDSAWTLKASDASDTIVINPNDVYEIAEVASTSVSRITGVSSEF 2065
F PV+LK+GNKYFQ++H+ K + ++ T I N+VY+I+ + S VS TGVSSEF
Sbjct: 2206 FCPVSLKIGNKYFQVLHEIPQLYKVTVSNRTFSIKFNNVYKISNLISVDVSNTTGVSSEF 2265
Query: 2066 CFELRNRKRLIMSSPKYLEILKMFYYSQAKILEEFNDNEYSDISSRHSKEAI-------- 2117
L N ++L+ SPKYLEI+KMFYY+Q K+ E+F + +DIS S A+
Sbjct: 2266 TLSLDNEEKLVFCSPKYLEIVKMFYYAQLKMEEDFGTDFSNDISFSTSSSAVNASYCNVK 2325
Query: 2118 KTADIVSHXXXXXXXXXXXDDE-IRVVSYNLLSSMHTTFSLNMGHLLPKTPDIYISEDPN 2176
+ +I+SH +D+ ++ +SYNLL + F+L+ G L K+P+ Y+ +D
Sbjct: 2326 EVGEIISHLSLVILVGLFNEDDLVKNISYNLLVATQEAFNLDFGTRLHKSPETYVPDDTT 2385
Query: 2177 PIFEPLIKTLAETSPELTSYYLKYSIDLLENGEHDLHFIANLLRTMRYWAKNLSKHVFLA 2236
+ K +E+S ELT Y KY +D LEN I ++ ++ YW NL +HV+LA
Sbjct: 2386 TFLALIFKAFSESSTELTPYIWKYMLDGLENDVIPQEHIPTVVCSLSYWVPNLYEHVYLA 2445
Query: 2237 DDQKGPEIATKLVRRLVKLTVQQNQPTSLYLDYIWPVLVHDSCLLKEVIEEVVGHCMDRA 2296
+D++GPE ++++ L++LTV++ T+ YL IW +L D L ++EE+V H +DR
Sbjct: 2446 NDEEGPEAISRIIYSLIRLTVKEPNFTTAYLQQIWFLLALDGRLTNVIVEEIVSHALDRD 2505
Query: 2297 AEGVDWHPACKILLRAPTIDITGVIIKRVIDITHSFLPNLKEETNVNSWTELIILVHLCS 2356
+E DW A IL PT +I +I+++I++ SFLP+L E + +SW+EL IL +
Sbjct: 2506 SENRDWMKAVSILTSFPTTEIACQVIEKLINMIKSFLPSLAVEASAHSWSELTILSKISV 2565
Query: 2357 SLFCDSPLLVDIYMPEVLYIVSLLIDVGSTEMRLSLHKLLMNACQSLLSNASLPKYNRRN 2416
S+F +SPLL +Y+PE+L+ VSLLIDVG +E+R+SL++LLMN C SL +N SLP+ NR+N
Sbjct: 2566 SIFFESPLLSQMYLPEILFAVSLLIDVGPSEIRVSLYELLMNVCHSLTNNESLPERNRKN 2625
Query: 2417 LYEIQKIFSDQKMKIMFGFSQERGRVLQNFSASSFLTKFTTLEHFVNNLMSLMDNGSLIN 2476
L + F+ QK+ + GFSQE+GRVL NF+ASSF +KF TL+ F N+M LM+ GS+
Sbjct: 2626 LDIVCATFARQKLNFISGFSQEKGRVLPNFAASSFSSKFGTLDLFTKNIMLLMEYGSISE 2685
Query: 2477 VEQWKTRYMQYIMGTVFHVQSFLSARAMMILGIVSKEGISDGLLLNLLRQSMVIVAMPDV 2536
QW+ +Y +Y+M +F +SF SARAMMILGI+SK S L LL ++M + A P V
Sbjct: 2686 GAQWEAKYKKYLMDAIFGHRSFFSARAMMILGIMSKSHTSLFLCKELLVETMKVFAEPVV 2745
Query: 2537 NDEQIFFVISTFFTYTKAVIGVDPQSPLLPKLFWLASSISFSINMMIYQSGLLFMSSTAQ 2596
+DEQ+F +I+ FTY+K V G+DP S L+ +LFWLA+ S + ++++ GLLFM + +
Sbjct: 2746 DDEQMFIIIAHVFTYSKIVEGLDPSSELMKELFWLATICVESPHPLLFEGGLLFMVNCLK 2805
Query: 2597 -----HLSLGSMEKMDRGEIPEPLIKQLMAQRNFGENILRQVEAMGDLRVTESNFSHVMI 2651
HL LG K L K+LM RNF +L ++E+ E NF H+++
Sbjct: 2806 RLYTVHLQLGFDGK--------SLAKKLMESRNFAATLLAKLESYNGCIWNEDNFPHIIL 2857
Query: 2652 SLICKGLLIPYTRATSLSSLVVFFKLFYFELMFGP-NEDYLIFMFFIFILQRPSAFLKCM 2710
I GL IP + +L L FK Y+E P + DYL ++F + ++ P +
Sbjct: 2858 GFIANGLSIPVVKGAALDCLQALFKNTYYERKSNPKSSDYLCYLFLLHLVLSPEQLSTLL 2917
Query: 2711 EDVDMDTDVVQLDDRNKIHKSLLDWLVKFSPDACLTMYKASLYFSCKATDEQGKVRFMLV 2770
+V + ++V L++ K+ +L++WL S + + +Y+ +L FSC +DE K RF L+
Sbjct: 2918 LEVGFEDELVPLNNTLKVPLTLINWLSSDSDKSNIVLYQGALLFSCVMSDEPCKFRFALL 2977
Query: 2771 YRHLMQHNLKAAFKLYPFVLNELRRLSKYSNNSSTVLLSFEIIKMAVKSKEYLKLPMIEK 2830
R+L++ N F+ Y E RRLS +S V +SFE+I M V E+ L
Sbjct: 2978 MRYLLKVNPICVFRFYTLTRKEFRRLSTLEQSSEAVAVSFELIGMLVTHSEFNYLEEFND 3037
Query: 2831 EMYKKLEERGLTGIKSIPFENELANDVLTGVRENPIITYERKKLAVMLLSKVISS 2885
EM + L++RGL+ +K + ++ + L G E+ + YERK+LA M+L+++ S
Sbjct: 3038 EMVELLKKRGLSVVKPLDIFDQEHIEKLKGEGEHQVAIYERKRLATMILARMSCS 3092
Score = 151 bits (382), Expect = 1e-35
Identities = 97/349 (27%), Positives = 174/349 (49%), Gaps = 30/349 (8%)
Query: 22 LLPVNSHVKTFEEVERDPYFTNIRLSLFNLVVSHGYSAI---SPAIVAKLEQIANLSKDK 78
+LP+ S++KT+ +VE D F + R + N+ ++ + I + ++ + Q ++ D
Sbjct: 30 VLPIESNLKTYADVEADSVFNSCRSIILNIAITKDLNPIIENTLGLIDLIVQDEEITSDN 89
Query: 79 NQDFDILLTLVVLLRMFTDTSEIYWRNLDPEYKLNYSLSDDSAFSRFYNGYSVQMASLHT 138
D DI +++VLLR+ +D E YW + K+ + G+S + HT
Sbjct: 90 ITD-DIAHSILVLLRLLSDVFEYYWDQNNDFKKIRND--------NYKPGFSSHRPNFHT 140
Query: 139 IRPKP--LSPQIANSFLQLLSRIKSNKRVIKMLNXXXXXXXXXXXXXXXXXXXXXXXXXX 196
RPK ++P +A L +S++K N R +K+L
Sbjct: 141 SRPKHTRINPALATMLLCKISKLKFNTRTLKVLQNMSHHLSGSATISKSSILPDSQEFLQ 200
Query: 197 XXXXXYYTYLVDVLDQHCAYLFKYIAASNPHEFHSFIRSVIITPLLVAHTHTESEIAPYL 256
YT +D+ Y+ ++I+ASN EF +++ ++ PLL++HT TE + +L
Sbjct: 201 KRNYPAYTEKIDLTID---YIQRFISASNHVEFTKCVKTKVVAPLLISHTSTELGVVNHL 257
Query: 257 CYFSFHYITSETLPSFLDVLQRMVVRMKKSIHQEILLYFASESIQSWIMARPHDYLRVIE 316
F Y+T + L ++LD+LQ + MK++I +LLY+AS++ WIMARP +Y+++
Sbjct: 258 DLFGCEYLTDKNLLAYLDILQHLSSYMKRTIFHSLLLYYASKAFLFWIMARPKEYVKIYN 317
Query: 317 GL-------QKNSSDPALQN------IQKISTSLFEDVFSSFNIERILT 352
L +SSD N I ++ + LF+DV+S+F++ +LT
Sbjct: 318 NLISSDYNSPSSSSDNGGSNNSDKTSISQLVSLLFDDVYSTFSVSSLLT 366
>Hs4557793 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 2818
Score = 271 bits (694), Expect = 9e-72
Identities = 363/1573 (23%), Positives = 657/1573 (41%), Gaps = 147/1573 (9%)
Query: 1158 SVEAKVSYFVGKQCSWL--NNED--LLTRENSKDILATELHPLAFDALFAALRQRIDELK 1213
+ + VS F+ + S + N+E L R N KD++ EL P + LF L+ I +
Sbjct: 886 NADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFF 945
Query: 1214 DIN--IVEKDNELSFILLEQVIMVVRMILER--DDTSEVLIIVSLP--LLNLIDDILRIV 1267
D ++ D F+ EQ I +++ +L+ + +SE L S+ +LNL+ + +
Sbjct: 946 DSQGQVLLTDTNTQFV--EQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLG 1003
Query: 1268 DTIDKSSPKYFKCVIHLSKMLKSFQHSESSICIAGYMVVKNRWLRLVTQWFQSAIFKEFD 1327
+ + K C ++++ + M +N+ + +T W
Sbjct: 1004 NMVHAIQIKTKLC-----QLVEVMMARRDDLSFCQEMKFRNKMVEYLTDW---------- 1048
Query: 1328 LLNLSKSHRDMDLE--KRDMDYLYIDTTIESSKAIAYLTKDLVLEAPQSMSEIELQRSKS 1385
++ S D D++ RD+D S +A+ L L L+ P+ +EL +KS
Sbjct: 1049 VMGTSNQAADDDVKCLTRDLDQA-------SMEAVVSLLAGLPLQ-PEEGDGVELMEAKS 1100
Query: 1386 VVFGNYFNILLKALEKSTNVENFPST-------LRHKIASLNENIIISLTNLLIANVDVG 1438
+F YF + + L + VE+ + + ++ASL +++++NLL ANVD G
Sbjct: 1101 QLFLKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSG 1160
Query: 1439 LNHATPIGYSNNRNIRLAFMNVFVNIV---SSFDISNNRTKRKRDEIVEEVVLMTLKRPT 1495
L H+ +GY + R FM V I+ + FD R E + E+V M +
Sbjct: 1161 LMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGE 1220
Query: 1496 L--LSKACRICPASDIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSC 1553
L + P S D LA +V FD ++ + ++ + +E+ A + R NS
Sbjct: 1221 LPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSL 1280
Query: 1554 ATRALSMLARLKGMDYLSNILKPILEELINSKE----CFDVE--KLDPNDV--DAPRNLM 1605
A++ ++ ++ G YL +L P+L +I S + F+V+ +L+P++ + RNL+
Sbjct: 1281 ASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNLL 1340
Query: 1606 LFKKYMTKVVDAITGSVDSFPPQFFVICQAIHSSASERFPEYADIAVGSFLFLRFFCPAL 1665
+ K AI S FPPQ +C ++ S+RFP+ + AVGS +FLRF PA+
Sbjct: 1341 QMTE---KFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNSIGAVGSAMFLRFINPAI 1397
Query: 1666 VSPDSEEIVDSLTPKARKSSMSL-AKVIQNIANGSVNSIKWKILESESEFLK-NCSNKIF 1723
VSP I+D P + + L +K++Q+IAN V K + + ++F+K N
Sbjct: 1398 VSPYEAGILDKKPPPRIERGLKLMSKILQSIAN-HVLFTKEEHMRPFNDFVKSNFDAARR 1456
Query: 1724 EFLSVVSDKNRKVKINLRMQNRVLPNEFSFLHKFLYYHGLEMRNALIEDIKSFDDLATVR 1783
FL + SD +N + + + LH+ L+ + ++ L + D A R
Sbjct: 1457 FFLDIASDCPTSDAVNHSL-SFISDGNVLALHRLLWNNQEKIGQYL---SSNRDHKAVGR 1512
Query: 1784 ETAEAVDELLSLMGQPRMEFKNEIPAYIREHSETSSELYEFMIKQAVKCPE---TPENEC 1840
+ + LL+ +G P E K + + TSS+ EFM + V E +
Sbjct: 1513 RPFDKMATLLAYLGPP--EHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLS 1570
Query: 1841 KFVQESVTSEGLPVVIFNWCEYQKDGNDDVETLIYLIFQIYSKVMTKKHFFVTDCTGFDG 1900
F Q + G P+ + + K G + + LIY + K + V D T
Sbjct: 1571 IFYQAGTSKAGNPIFYYVARRF-KTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTH--- 1626
Query: 1901 VRQPKNRF-VKLSSLFFNLIPAEGLANCETFYFFNPTPIYLEWWTEFQNSHANIFQNMNV 1959
P NRF S +F + P N Y +N W E+ H + +
Sbjct: 1627 -TGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCN----SWVREYTKYHERLLTGLKG 1681
Query: 1960 SMSFLNTDSDPKLIKALGLSDYSKEVYHDVRVTL-HDVSLYDEAKR---QFSPVTLKVGN 2015
S + D KL + + ++ ++ + L D+ ++ A + + + V++KVG+
Sbjct: 1682 SKRLVFIDCPGKLAEHI---EHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGS 1738
Query: 2016 KYFQIVHDSAWTLKASDASDTIVINPNDVYEIAEVASTSVSRITGVSSEFCFELRNRKRL 2075
Q+ SA K S + ND+Y +E+ + ++F + N+
Sbjct: 1739 TAVQVT--SAERTKVLGQS----VFLNDIYYASEIEEICLVD----ENQFTLTIANQGTP 1788
Query: 2076 IMSSPKYLEILKMFYYSQAKILEEFNDNEYSDISSRHSKEAIKTADIV-SHXXXXXXXXX 2134
+ + E + I+ E S S I+ D+ +
Sbjct: 1789 LTFMHQECEAIVQ------SIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLG 1842
Query: 2135 XXDDEIRVVSYNLLSSMHTTFSLNMGHLLPKTPDIYISEDPNPIFEPLIKTLAETSPELT 2194
D +R +YNLL ++ TF+L + L +T + I + + KTLA P LT
Sbjct: 1843 SSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLT 1902
Query: 2195 SYYLKYSIDLLENGEHDLHFIANLLRTMRYWAKNLSKHVFLADDQKGPEIATKLVRRLVK 2254
+L+ I +L + L M W NL + DD K + T ++ +L+
Sbjct: 1903 LEFLEECISGFSKSSIELKHLC--LEYMTPWLSNLVRFCKHNDDAKRQRV-TAILDKLIT 1959
Query: 2255 LTVQQNQPTSLYLDYIWPVLVHDSCLLKEVIEEVVGHCMDRAAEGVDWHPACKILLRAPT 2314
+T+ + Q IW L + LL V++ + + + +
Sbjct: 1960 MTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALAS 2019
Query: 2315 IDITGVIIK------RVIDIT-HSFLPNLKEETNVNSWTELIILVHLCSSLFCDSPLLVD 2367
++ V K ++ID T S P L++ W ++ IL L ++ L V
Sbjct: 2020 GNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHL---MWDDIAILARYMLMLSFNNSLDVA 2076
Query: 2368 IYMPEVLYIVSLLIDVGSTEMRLSLHKLLMNACQSLLSNASL--PKYNRRNLYEIQKIFS 2425
++P + ++V+ L+ G +R S H L++N SL + + L + ++ L FS
Sbjct: 2077 AHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFS 2136
Query: 2426 DQKMKIMFGFSQERGRVL---------QNFSASSFLTK---FTTLEHFVNNLMSLMDNGS 2473
K ++FG S+ + + ++FS S+ + T+LE L+ +M+
Sbjct: 2137 LPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACM 2196
Query: 2474 L-INVEQWKTRYMQYIMGTVFHVQSFLSARAMMILGIVSKEGISDGLLLNLLRQSMVIVA 2532
I +W ++ + F L RA+++ G +SK +S G + ++R +
Sbjct: 2197 RDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKR-VSHGQIKQIIRILSKALE 2255
Query: 2533 M----PDVNDEQIFFVISTFFTYTKAVIGVDPQSPLLPKLFWLASSISFSINMMIYQSGL 2588
PD + Q+ + +T TK ++ SPL LFW+A ++ + +Y +G
Sbjct: 2256 SCLKGPDTYNSQV-LIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGT 2314
Query: 2589 LFMSSTAQHLSLGSMEKMDRGEIPEPLIKQLMAQRNFGENILRQVEAMGDLRVTESNFSH 2648
+ Q+L ++ + PE + MA RN E +Q++ L SNF+
Sbjct: 2315 ALLE---QNLHTLDSLRIFNDKSPEEV---FMAIRNPLEWHCKQMDHFVGLNF-NSNFNF 2367
Query: 2649 VMISLICKGLLIP 2661
++ + KG P
Sbjct: 2368 ALVGHLLKGYRHP 2380
>7301417 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 2802
Score = 270 bits (689), Expect = 3e-71
Identities = 373/1615 (23%), Positives = 675/1615 (41%), Gaps = 181/1615 (11%)
Query: 1163 VSYFVGKQCSWL--NNED--LLTRENSKDI----LATELHPLAFDALFAALRQRIDELKD 1214
V+ FVG+ L +NE L ++N K++ ++T+L+P+ FD + A + + D+
Sbjct: 910 VTQFVGQLLRLLVCSNEKIGLNIQKNVKELVGEEMSTQLYPILFDQVRAIVEKFFDQQGQ 969
Query: 1215 INIVEKDNELSFILLEQVIMVVRMILE----------RDDTSEVLIIVSLPLLNLIDDIL 1264
+N+ D FI E I +++ IL+ + SE L + S+ + L I+
Sbjct: 970 VNVNVTDINTQFI--EHTIYIMKSILDPKANKDPNNDQPSPSEHLGVTSIEGMML--GIV 1025
Query: 1265 RIVDTIDKSSPKYFKCVIHLSKMLKSFQHSESSICIAGYMVVKNRWLRLVTQWF-----Q 1319
R V +D + + L ++++ + M +N+ + +T W Q
Sbjct: 1026 RYVRHLDMTVYA-IRIKTKLCQLVEVMMKRRDDLAFRQEMKFRNKLVEYLTDWVMGTSHQ 1084
Query: 1320 SAIFKEFDLLNLSKSHRDMDLEKRDMDYLYIDTTIESSKAIAYLTKDLVLEAPQSMSEIE 1379
A D L+ + L RD+D ++ A+A L + L L+ P+ +
Sbjct: 1085 IAPPSSADAAILTNT----SLIFRDLDQACME-------AVAALLRGLPLQ-PEESDRGD 1132
Query: 1380 LQRSKSVVFGNYFNILLKAL---------EKSTN----VENFPSTLRHKIASLNENIIIS 1426
L +KS +F YF + + L EK N + P K+ +L I++
Sbjct: 1133 LMDAKSALFLKYFTLFMNLLNDCIDSSEAEKEMNNTPLLPPRPRMAAGKLTALRNATILA 1192
Query: 1427 LTNLLIANVDVGLNHATPIGYSNNRNIRLAFMNVFVNIV---SSFD-ISNNRTKRKRDEI 1482
++NLL AN+D GL H+ +GY+ + R AFM V I+ + FD ++ + +++
Sbjct: 1193 MSNLLGANIDSGLMHSIDLGYNPDLQTRAAFMEVLTQILQQGTEFDTLAETVLADRFEQL 1252
Query: 1483 VEEVVLMTLKRPTLLSKA-CRICPASDIDALASSIVYFFDVKNAAHIIVTELVREEIGNA 1541
V+ V +++ K ++ A + S +D LA +V FD K+ ++ + E+ +
Sbjct: 1253 VQLVTMISDKGELPIAMALANVVTTSQMDELARVLVTLFDAKHLLSPLLWNMFYREVEVS 1312
Query: 1542 TRHMEILRRNSCATRALSMLARLKGMDYLSNILKPILEELINSKE--CFDVE--KLDP-N 1596
+ R NS ++ ++ ++ G YL +L+P++ L++ +E CF+V+ +LDP
Sbjct: 1313 DCMQTLFRGNSLGSKIMAFCFKIYGASYLQMLLEPLIRPLLDEEEETCFEVDPARLDPTE 1372
Query: 1597 DVDAPRNLMLFKKYMTKVVDAITGSVDSFPPQFFVICQAIHSSASERFPEYADI---AVG 1653
D++ RN ++ KV DAI S D FPPQ +C ++ S+RFP AVG
Sbjct: 1373 DIEQHRNNLI--ALTQKVFDAIINSSDRFPPQLRSMCHCLYQVLSKRFPNLLQNNIGAVG 1430
Query: 1654 SFLFLRFFCPALVSPDSEEIVD-SLTPKARKSSMSLAKVIQNIANGSVNSIKWKILESES 1712
+ +FLRF PA+VSP IVD + A++ M ++K++QNIAN V K + + +
Sbjct: 1431 TVIFLRFINPAIVSPQELGIVDKQVHSSAKRGLMLMSKILQNIAN-HVEFSKEQHMLCFN 1489
Query: 1713 EFLKNCSNKIFEFLSVVSDKNRKVKINLRMQNRVLPNEFSFLHKFLYYHGLEMRNALIED 1772
+FL++ F ++ V + + LH+ L+ H ++ + L
Sbjct: 1490 DFLRDHFEAGRRFFIQIASDCETVDQTSHSMSFISDANVLALHRLLWTHQEKIGDYL--- 1546
Query: 1773 IKSFDDLATVRETAEAVDELLSLMGQPR---MEFKNEIPAYIREHS--ETSSELYEFMIK 1827
S D A R + + LL+ +G P ++ +Y R S +S+ E M+K
Sbjct: 1547 SSSRDHKAVGRRPFDKMATLLAYLGPPEHKPVDSHMMFSSYARWSSIDMSSTNFEEIMVK 1606
Query: 1828 QAVKCPE---TPENECKFVQESVTSEGLPVVIFNWCEYQKDGNDDVETLIYLIFQIYSKV 1884
+ E T ++ F Q + G PV + Y K G + + LIY +
Sbjct: 1607 HQMHEKEEFKTLKSMNIFYQAGTSKSGYPVFYYIARRY-KIGETNGDLLIYHVILTLKPF 1665
Query: 1885 MTKKHFFVTDCTGFDGVRQPKNRFVKLSSLFFNLIPAEGLANCETFYFFNPTPIYLEWWT 1944
V D T + + F++ +F ++P N Y +N W
Sbjct: 1666 CHSPFEVVIDFTHTCSDNRFRTEFLQ---KWFYVLPTVAYENVHAVYIYNCN----SWVR 1718
Query: 1945 EFQNSHANIFQNMNVSMSFLNTDSDPKLIKALGLSDYSKEVYHDVRVTL-HDVSLYDEA- 2002
E+ H I + + L +S KL + D ++ ++L D+ ++ A
Sbjct: 1719 EYTKFHDRILAPLKGNRKLLFLESPNKLTDFI---DAEQQKLPGATLSLDEDLKVFSNAL 1775
Query: 2003 --KRQFSPVTLKVGNKYFQIVHDSAWTLKASDASDTIVINPNDVY---EIAEVASTSVSR 2057
+ + V +KVG QI K + ++++ NDVY EI EV ++
Sbjct: 1776 KLSHKDTKVAIKVGPTALQITSAE----KTKVLAHSVLL--NDVYYASEIEEVCLVDDNQ 1829
Query: 2058 ----ITGVSSEFCFELRNRKRLIMSSPKYLEILKMFYYSQAKILEEFNDNEYSDISSRHS 2113
IT S + F + ++ + I+ N E S S
Sbjct: 1830 FTLSITNESGQLSFIHNDCDNIVQA-----------------IIHIRNRWELSQPDSVTV 1872
Query: 2114 KEAIKTADIVSHXXXXXXXXXXX-DDEIRVVSYNLLSSMHTTFSLNMGHLLPKTPDIYIS 2172
+ I+ D+ D +R +YNLL ++ TF L + L +T + I
Sbjct: 1873 HQKIRPKDVPGTLLNMALLNLGSCDPNLRTAAYNLLCALTATFDLKIEGQLLETQGLCIP 1932
Query: 2173 EDPNPIFEPLIKTLAETSPELTSYYLKYSIDLLENGEHDLHFIANLLRTMRYWAKNLSKH 2232
+ + + + LA P LT +L+ SI + +L + L M W KNL K
Sbjct: 1933 SNNTIFIKSVSEKLATNEPHLTLEFLEESIQGFQRSTIELKHLC--LEYMTPWLKNLVKF 1990
Query: 2233 VFLADDQKGPEIATKLVRRLVKLTVQQNQPTSLYLDYIWPVLVHDSCLLKEVIEEVVGHC 2292
DD K ++ ++++ +L+ LT+ Q + IW + + E+I+ V+ +
Sbjct: 1991 CKSNDDSKKLKV-SQILDKLINLTIDQKEMYPSVQAKIWGSIGQ----IPELIDMVLDNF 2045
Query: 2293 MDRAAEGVDWHPACKI-------LLRAPTIDITGVIIKRVIDITHSFLPNLKEETNVN-S 2344
+ ++ P +I L A ++ +I R+ + N + +
Sbjct: 2046 LHKSITYGLGSPQVEIMADTAVALASANVQLVSKKVITRICRVMDKSCTNPTQYLEQHMM 2105
Query: 2345 WTELIILVHLCSSLFCDSPLLVDIYMPEVLYIVSLLIDVGSTEMRLSLHKLLMNACQSL- 2403
W ++ IL L ++ L V +P + + ++ L+ GS MR S H L++N SL
Sbjct: 2106 WDDIAILGRYLLMLSFNNCLDVATSVPYLFHTITFLVCSGSLSMRASTHGLVINIIHSLC 2165
Query: 2404 -LSNASLPKYNRRNLYEIQKIFSDQKMKIMFGFSQERG---------------------R 2441
+N S + +R L FS K ++FG S+ + R
Sbjct: 2166 TCTNPSFSEEAQRVLRLSLDEFSLPKFYLLFGISKVKSAAVTAFRSSCRHPTDKWLGNER 2225
Query: 2442 VLQNFSASSFLTKFTTLEHFVNNLMSLMDNGSLINVE--QWKTRYMQYIMGTVFHVQSFL 2499
V Q A +LE + L+ +M+ + +V +W + F L
Sbjct: 2226 VTQPLPADRERLSLPSLEVITDALLEIME-ACMRDVPDCEWLNTWTSLARSFAFCYNPAL 2284
Query: 2500 SARAMMILGIVSKEGISDGLLLNLLRQSMVIVAMPDVNDEQIFFVISTFFTYTKAVIGVD 2559
RA+++ G +SK ++D + LLR +++ A+ ND + + + T+ +
Sbjct: 2285 QPRALIVYGCISK-SVTDHEVKQLLR--ILVKALESFND--LILIEALVMCLTRIQPLLR 2339
Query: 2560 PQSPLLPKLFWLASSISFSINMMIYQSGLLFMSSTAQHL-SLGSMEKMDRGEIPEPLIKQ 2618
P+SP+ LFW+A S+ + +Y +GL + L S G +K E + +
Sbjct: 2340 PESPIHRALFWVAISVLQLDEITLYGAGLALLEQNLHTLKSQGCFDK------KETIAEV 2393
Query: 2619 LMAQRNFGENILRQVEAMGDLRVTESNFSHVMISLICKGLLIPYTRATSLSSLVV 2673
+M R E +Q++ L SNF ++ + KG P S +S V+
Sbjct: 2394 MMKTREKLEWHFKQLDHAVGLSF-RSNFHFALVGHLIKGFRHPTPTTVSRTSRVL 2447
>Hs4759026 [T] KOG2059 Ras GTPase-activating protein
Length = 804
Score = 99.4 bits (246), Expect = 8e-20
Identities = 72/246 (29%), Positives = 116/246 (46%), Gaps = 29/246 (11%)
Query: 1512 LASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGMDYLS 1571
LA+ +V F + A + L R E+ + R NS A++++ +L GM YL
Sbjct: 305 LATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLH 364
Query: 1572 NILKPILEELINSKECFDVEKLDPNDVDAPR------------------NLMLFKKYMTK 1613
+LKP++ + K+ + LDP +D R +L L Y+
Sbjct: 365 EVLKPVISRVFEEKKYME---LDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGP 421
Query: 1614 VVDAITGSVDSFPPQFFVICQAIHSSASERFP--EYADI---AVGSFLFLRFFCPALVSP 1668
+VDAI GSV PP + + +H ERFP E+ D+ A+ FLFLRFF PA+++P
Sbjct: 422 IVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTP 481
Query: 1669 DSEEIVDS-LTPKARKSSMSLAKVIQNIAN--GSVNSIKWKILESESEFLKNCSNKIFEF 1725
++ D P+ +S + LAK +Q+I N + K + FL C +++ +F
Sbjct: 482 KLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDF 541
Query: 1726 LSVVSD 1731
L + D
Sbjct: 542 LDRLVD 547
>7294865 [T] KOG2059 Ras GTPase-activating protein
Length = 1163
Score = 80.9 bits (198), Expect = 3e-14
Identities = 55/194 (28%), Positives = 93/194 (47%), Gaps = 11/194 (5%)
Query: 1512 LASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGMDYLS 1571
+A +V F I+ L EI + T I R N+ ++ + RL G+ YL
Sbjct: 508 VAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLH 567
Query: 1572 NILKPILEELINSKECFDVEKLDPNDVDA-PRNLMLFKKYMTKVVDAITGSVDSFPPQFF 1630
L+P+L +++ K+ +++ D A NL + Y+ +V +AIT S D P
Sbjct: 568 QTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPK--- 624
Query: 1631 VICQAIH---SSASERFPEYADI---AVGSFLFLRFFCPALVSPDSEEI-VDSLTPKARK 1683
V+CQ H A E FP ++ V F+FLRFF PA++ P ++ + L + +
Sbjct: 625 VLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSR 684
Query: 1684 SSMSLAKVIQNIAN 1697
+ ++K IQ++ N
Sbjct: 685 TLTLISKTIQSLGN 698
>Hs12545410 [T] KOG2059 Ras GTPase-activating protein
Length = 834
Score = 80.5 bits (197), Expect = 4e-14
Identities = 58/216 (26%), Positives = 110/216 (50%), Gaps = 10/216 (4%)
Query: 1530 VTELVREEIGNATRHMEILRRNSCATRALSMLARLKGMDYLSNILKPILEELINSKECFD 1589
++ + E+ I R NS A++ + +L GM YL LKP +EE+ S + +
Sbjct: 352 ISAIASAEVKRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCE 411
Query: 1590 VEKLDPND-VDAPRNLMLFKKYMTKVVDAITGSVDSFPPQFFVICQAIHSSASERFPEYA 1648
++ + D + N+ ++Y+ +V AIT S S P I ++ +A++RF +
Sbjct: 412 IDPVKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDP 471
Query: 1649 DI---AVGSFLFLRFFCPALVSPDSEEIVDSLT-PKARKSSMSLAKVIQNIANGSVN--- 1701
D+ AV SF+FLRFF PA++SP+ ++ T P+ ++ ++K +Q + + S +
Sbjct: 472 DVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSA 531
Query: 1702 SIKWKILESESEFL--KNCSNKIFEFLSVVSDKNRK 1735
S K + + EF + ++ + FL ++S R+
Sbjct: 532 SFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRR 567
>7293174 [R] KOG3508 GTPase-activating protein
Length = 925
Score = 77.4 bits (189), Expect = 3e-13
Identities = 68/286 (23%), Positives = 128/286 (43%), Gaps = 16/286 (5%)
Query: 1512 LASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGMDYLS 1571
LA++++ F + ++ L + E+ + R S AT + + R + +L
Sbjct: 629 LATALLRVFRQEKRETELIRMLCQAEVTRENETTTLFRGASLATTLMDLYMRTECSGFLQ 688
Query: 1572 NILKPILEELINSKECFDVE--KLDPNDVDAPRNLMLFKKYMTKVVDAITGSVDSFPPQF 1629
+ + ++ ++ SK+ ++ K+D ND DA N + + V +I S D+ P
Sbjct: 689 SAVSETVQRILESKQSAELNPTKMDVND-DACTNAEFLLQILDLVTQSIFTSPDACPRNV 747
Query: 1630 FVICQAIHSSASERFPEYADI---AVGSFLFLRFFCPALVSPDSEEIVDSLTP-KARKSS 1685
IC + + ++P + V F+FLR CPAL++P +V P A +S
Sbjct: 748 RFICSCLQKAVMAKWPTERLVRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSL 807
Query: 1686 MSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEF---LSVVSDKNRK----VKI 1738
+ +AK +QN+AN K + +E + F+ ++ F LS V+D N+ V+
Sbjct: 808 VMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQ 867
Query: 1739 NLRMQNRVLPNEFSFLHKFLYYHGLEMRNALIEDIKSFDDLATVRE 1784
+ + ++ E + LH H E+ + +I S L TV +
Sbjct: 868 STNLNSQDTGRELATLHHICVSHSQELHE--LSNILSIKKLVTVTD 911
>CE28277 [R] KOG3508 GTPase-activating protein
Length = 787
Score = 76.6 bits (187), Expect = 5e-13
Identities = 59/235 (25%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 1508 DIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGM 1567
D + LA+S+V N A + +L+ +E+ + R N+ AT+A+ +L
Sbjct: 143 DKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVAD 202
Query: 1568 DYLSNILKPILEELINSKECFDVEKLDP------NDVDAPRNLMLFKKYMTKVVDAITGS 1621
DYL + L ++ ++ +C D ++DP ++ +N L +Y+ I +
Sbjct: 203 DYLDSTLSDFIKTVL---QCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNN 259
Query: 1622 VDSFPPQFFVICQAIHSSASERFPE-YADIAVGSFLFLRFFCPALVSPDSEEIVDSL-TP 1679
V P + A+ + E AD + S +FLRF CPA++SP +V +P
Sbjct: 260 VHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSP 319
Query: 1680 KARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNR 1734
++ +AK +QN+AN S K +E +EF+ +++ +FL +S +++
Sbjct: 320 TNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESK 374
>CE23475 [R] KOG3508 GTPase-activating protein
Length = 956
Score = 76.6 bits (187), Expect = 5e-13
Identities = 59/235 (25%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 1508 DIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGM 1567
D + LA+S+V N A + +L+ +E+ + R N+ AT+A+ +L
Sbjct: 312 DKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVAD 371
Query: 1568 DYLSNILKPILEELINSKECFDVEKLDP------NDVDAPRNLMLFKKYMTKVVDAITGS 1621
DYL + L ++ ++ +C D ++DP ++ +N L +Y+ I +
Sbjct: 372 DYLDSTLSDFIKTVL---QCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNN 428
Query: 1622 VDSFPPQFFVICQAIHSSASERFPE-YADIAVGSFLFLRFFCPALVSPDSEEIVDSL-TP 1679
V P + A+ + E AD + S +FLRF CPA++SP +V +P
Sbjct: 429 VHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSP 488
Query: 1680 KARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNR 1734
++ +AK +QN+AN S K +E +EF+ +++ +FL +S +++
Sbjct: 489 TNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESK 543
>CE23474 [R] KOG3508 GTPase-activating protein
Length = 1048
Score = 76.6 bits (187), Expect = 5e-13
Identities = 59/235 (25%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 1508 DIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGM 1567
D + LA+S+V N A + +L+ +E+ + R N+ AT+A+ +L
Sbjct: 404 DKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVAD 463
Query: 1568 DYLSNILKPILEELINSKECFDVEKLDP------NDVDAPRNLMLFKKYMTKVVDAITGS 1621
DYL + L ++ ++ +C D ++DP ++ +N L +Y+ I +
Sbjct: 464 DYLDSTLSDFIKTVL---QCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNN 520
Query: 1622 VDSFPPQFFVICQAIHSSASERFPE-YADIAVGSFLFLRFFCPALVSPDSEEIVDSL-TP 1679
V P + A+ + E AD + S +FLRF CPA++SP +V +P
Sbjct: 521 VHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSP 580
Query: 1680 KARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNR 1734
++ +AK +QN+AN S K +E +EF+ +++ +FL +S +++
Sbjct: 581 TNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESK 635
>CE23473 [R] KOG3508 GTPase-activating protein
Length = 1137
Score = 76.6 bits (187), Expect = 5e-13
Identities = 59/235 (25%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 1508 DIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGM 1567
D + LA+S+V N A + +L+ +E+ + R N+ AT+A+ +L
Sbjct: 493 DKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVAD 552
Query: 1568 DYLSNILKPILEELINSKECFDVEKLDP------NDVDAPRNLMLFKKYMTKVVDAITGS 1621
DYL + L ++ ++ +C D ++DP ++ +N L +Y+ I +
Sbjct: 553 DYLDSTLSDFIKTVL---QCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNN 609
Query: 1622 VDSFPPQFFVICQAIHSSASERFPE-YADIAVGSFLFLRFFCPALVSPDSEEIVDSL-TP 1679
V P + A+ + E AD + S +FLRF CPA++SP +V +P
Sbjct: 610 VHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSP 669
Query: 1680 KARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNR 1734
++ +AK +QN+AN S K +E +EF+ +++ +FL +S +++
Sbjct: 670 TNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESK 724
>CE23472 [R] KOG3508 GTPase-activating protein
Length = 1259
Score = 76.6 bits (187), Expect = 5e-13
Identities = 59/235 (25%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 1508 DIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGM 1567
D + LA+S+V N A + +L+ +E+ + R N+ AT+A+ +L
Sbjct: 615 DKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVAD 674
Query: 1568 DYLSNILKPILEELINSKECFDVEKLDP------NDVDAPRNLMLFKKYMTKVVDAITGS 1621
DYL + L ++ ++ +C D ++DP ++ +N L +Y+ I +
Sbjct: 675 DYLDSTLSDFIKTVL---QCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNN 731
Query: 1622 VDSFPPQFFVICQAIHSSASERFPE-YADIAVGSFLFLRFFCPALVSPDSEEIVDSL-TP 1679
V P + A+ + E AD + S +FLRF CPA++SP +V +P
Sbjct: 732 VHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSP 791
Query: 1680 KARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNR 1734
++ +AK +QN+AN S K +E +EF+ +++ +FL +S +++
Sbjct: 792 TNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESK 846
>CE23471 [R] KOG3508 GTPase-activating protein
Length = 1170
Score = 76.6 bits (187), Expect = 5e-13
Identities = 59/235 (25%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 1508 DIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGM 1567
D + LA+S+V N A + +L+ +E+ + R N+ AT+A+ +L
Sbjct: 526 DKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVAD 585
Query: 1568 DYLSNILKPILEELINSKECFDVEKLDP------NDVDAPRNLMLFKKYMTKVVDAITGS 1621
DYL + L ++ ++ +C D ++DP ++ +N L +Y+ I +
Sbjct: 586 DYLDSTLSDFIKTVL---QCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNN 642
Query: 1622 VDSFPPQFFVICQAIHSSASERFPE-YADIAVGSFLFLRFFCPALVSPDSEEIVDSL-TP 1679
V P + A+ + E AD + S +FLRF CPA++SP +V +P
Sbjct: 643 VHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSP 702
Query: 1680 KARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNR 1734
++ +AK +QN+AN S K +E +EF+ +++ +FL +S +++
Sbjct: 703 TNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESK 757
>CE23470 [R] KOG3508 GTPase-activating protein
Length = 1207
Score = 76.6 bits (187), Expect = 5e-13
Identities = 59/235 (25%), Positives = 111/235 (47%), Gaps = 11/235 (4%)
Query: 1508 DIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGM 1567
D + LA+S+V N A + +L+ +E+ + R N+ AT+A+ +L
Sbjct: 563 DKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVAD 622
Query: 1568 DYLSNILKPILEELINSKECFDVEKLDP------NDVDAPRNLMLFKKYMTKVVDAITGS 1621
DYL + L ++ ++ +C D ++DP ++ +N L +Y+ I +
Sbjct: 623 DYLDSTLSDFIKTVL---QCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNN 679
Query: 1622 VDSFPPQFFVICQAIHSSASERFPE-YADIAVGSFLFLRFFCPALVSPDSEEIVDSL-TP 1679
V P + A+ + E AD + S +FLRF CPA++SP +V +P
Sbjct: 680 VHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSP 739
Query: 1680 KARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNR 1734
++ +AK +QN+AN S K +E +EF+ +++ +FL +S +++
Sbjct: 740 TNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESK 794
>Hs4506431 [R] KOG3508 GTPase-activating protein
Length = 1047
Score = 71.6 bits (174), Expect = 2e-11
Identities = 62/276 (22%), Positives = 123/276 (44%), Gaps = 12/276 (4%)
Query: 1497 LSKACRICPASDIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATR 1556
LS C D LAS ++ F + +++ L EI + R + A+
Sbjct: 741 LSHVC----GQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLAST 796
Query: 1557 ALSMLARLKGMDYLSNILKPILEELINSKECFDVE--KLDPNDVDAPRNLMLFKKYMTKV 1614
+ + ++ + LK + +++ SK+ ++ KL+ N+ D NL ++++
Sbjct: 797 LMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNE-DVNTNLTHLLNILSEL 855
Query: 1615 VDAITGSVDSFPPQFFVICQAIHSSASERFPEYADI---AVGSFLFLRFFCPALVSPDSE 1671
V+ I + + PP I + S ++P + V F+FLR CPA+++P
Sbjct: 856 VEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMF 915
Query: 1672 EIV-DSLTPKARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVS 1730
I+ DS +P A ++ + +AK +QN+AN K +E + F+K+ +++ FL +
Sbjct: 916 NIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELG 975
Query: 1731 DKNRKVKINLRMQNRVLPNEFSFLHKFLYYHGLEMR 1766
+ ++ L + + LH+ H E+R
Sbjct: 976 NV-PELPDTTEHSRTDLSRDLAALHEICVAHSDELR 1010
>Hs12545406 [R] KOG3508 GTPase-activating protein
Length = 870
Score = 71.6 bits (174), Expect = 2e-11
Identities = 62/276 (22%), Positives = 123/276 (44%), Gaps = 12/276 (4%)
Query: 1497 LSKACRICPASDIDALASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATR 1556
LS C D LAS ++ F + +++ L EI + R + A+
Sbjct: 564 LSHVC----GQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLAST 619
Query: 1557 ALSMLARLKGMDYLSNILKPILEELINSKECFDVE--KLDPNDVDAPRNLMLFKKYMTKV 1614
+ + ++ + LK + +++ SK+ ++ KL+ N+ D NL ++++
Sbjct: 620 LMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNE-DVNTNLTHLLNILSEL 678
Query: 1615 VDAITGSVDSFPPQFFVICQAIHSSASERFPEYADI---AVGSFLFLRFFCPALVSPDSE 1671
V+ I + + PP I + S ++P + V F+FLR CPA+++P
Sbjct: 679 VEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMF 738
Query: 1672 EIV-DSLTPKARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVS 1730
I+ DS +P A ++ + +AK +QN+AN K +E + F+K+ +++ FL +
Sbjct: 739 NIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELG 798
Query: 1731 DKNRKVKINLRMQNRVLPNEFSFLHKFLYYHGLEMR 1766
+ ++ L + + LH+ H E+R
Sbjct: 799 NV-PELPDTTEHSRTDLSRDLAALHEICVAHSDELR 833
>Hs22060041 [R] KOG3508 GTPase-activating protein
Length = 877
Score = 70.1 bits (170), Expect = 5e-11
Identities = 63/253 (24%), Positives = 112/253 (43%), Gaps = 3/253 (1%)
Query: 1510 DALASSIVYFFDVKNAAHIIVTELVREEIGN-ATRHMEILRRNSCATRALSMLARLKGMD 1568
+ +AS++V+ A ++++ E+ R I R N+ AT+A+ RL G
Sbjct: 37 EEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQK 96
Query: 1569 YLSNILKPILEELINSKECFDVEKLDPNDVDAPRNLMLFKKYMTKVVDAITGSVDSFPPQ 1628
YL + + + L S+E +V+ + + + + + S FP +
Sbjct: 97 YLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRE 156
Query: 1629 FFVICQAIHSSASERFPE-YADIAVGSFLFLRFFCPALVSPDSEEIVDSLTPKARKSSMS 1687
+ + +ER E AD + + LFLRF CPA++SP ++ + +++
Sbjct: 157 LKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLT 216
Query: 1688 L-AKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNRKVKINLRMQNRV 1746
L AKVIQN+AN S + K L +EFL+ + +FL +S+ + +
Sbjct: 217 LIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYID 276
Query: 1747 LPNEFSFLHKFLY 1759
L E S LH L+
Sbjct: 277 LGRELSTLHALLW 289
>Hs20070109 [R] KOG3508 GTPase-activating protein
Length = 967
Score = 70.1 bits (170), Expect = 5e-11
Identities = 63/275 (22%), Positives = 117/275 (41%), Gaps = 5/275 (1%)
Query: 1503 ICPASDIDALASSIVYFFDVKNAAHIIVTELVREEIGNA--TRHMEILRRNSCATRALSM 1560
I A + +AS++V+ +T+L+ E+ H+ I R N+ AT+A+
Sbjct: 173 ILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHL-IFRENTLATKAIEE 231
Query: 1561 LARLKGMDYLSNILKPILEELINSKECFDVEKLDPNDVDAPRNLMLFKKYMTKVVDAITG 1620
+L G YL + L ++ L S E +V+ + D P + K
Sbjct: 232 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKTIN 291
Query: 1621 SVDSFPPQFFVICQAIHSSASER-FPEYADIAVGSFLFLRFFCPALVSPDSEEIVDSLTP 1679
S FP + + + S R P+ ++ + + LFLRF CPA++SP ++
Sbjct: 292 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 351
Query: 1680 KARKSSMSL-AKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDKNRKVKI 1738
+++L AKV QN+AN + K + + ++FL++ + FL +S+
Sbjct: 352 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 411
Query: 1739 NLRMQNRVLPNEFSFLHKFLYYHGLEMRNALIEDI 1773
L E S LH L+ ++ +++ +
Sbjct: 412 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKL 446
>Hs12545408 [T] KOG2059 Ras GTPase-activating protein
Length = 849
Score = 68.6 bits (166), Expect = 1e-10
Identities = 56/178 (31%), Positives = 91/178 (50%), Gaps = 9/178 (5%)
Query: 1547 ILRRNSCATRALSMLARLKGMDYLSNILKPILEELINSKECFDVEKLDPNDVD-APRNLM 1605
I R NS ATR L + ++ G YL LKPIL+E+ +S + +++ + + D N
Sbjct: 395 IFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKE 454
Query: 1606 LFKKYMTKVVDAITGSVDSFPPQFFVICQAIHSSASERFPEYADI---AVGSFLFLRFFC 1662
+ Y+ K+ + I S S P I ++ A++RFP + AV SF+FLRFF
Sbjct: 455 NLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFA 514
Query: 1663 PALVSPDSEEIVDSLTPKAR--KSSMSLAKVIQNIAN-GSVNSIKWKILES-ESEFLK 1716
A+VSP + + P A+ ++ ++K IQ + + GS++ K E+ EF K
Sbjct: 515 VAVVSPHTFHLRPH-HPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMCEFFK 571
>SPBC646.12c [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 766
Score = 66.6 bits (161), Expect = 6e-10
Identities = 41/128 (32%), Positives = 69/128 (53%), Gaps = 10/128 (7%)
Query: 1604 LMLFKKYMTKVVDAITGSVDSFPPQFFVICQAIHSSASERFPEYADIAV----GSFLFLR 1659
L+L K+++ DA+ S+D P +C+ I + + FP +D + G F FLR
Sbjct: 285 LLLTKRFL----DAVLNSIDEIPYGIRWVCKLIRNLTNRLFPSISDSTICSLIGGFFFLR 340
Query: 1660 FFCPALVSPDSEEIVDSL-TPKARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNC 1718
F PA++SP + ++DS + RK+ ++AK+IQ++ANG+ +S K + S LK
Sbjct: 341 FVNPAIISPQTSMLLDSCPSDNVRKTLATIAKIIQSVANGT-SSTKTHLDVSFQPMLKEY 399
Query: 1719 SNKIFEFL 1726
K+ L
Sbjct: 400 EEKVHNLL 407
>Hs20546119 [R] KOG3508 GTPase-activating protein
Length = 478
Score = 65.9 bits (159), Expect = 9e-10
Identities = 49/175 (28%), Positives = 80/175 (45%), Gaps = 3/175 (1%)
Query: 1526 AHIIVTELVREEIGNAT-RHMEILRRNSCATRALSMLARLKGMDYLSNILKPILEELINS 1584
A +VT+L E+ R + R N+ AT+A+ +L DYL L ++ L S
Sbjct: 11 AQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCAS 70
Query: 1585 KECFDVEKLDPNDVDAPRNLMLFKKYMTKVVDAITGSVDSFPPQFFVICQAIHSSASERF 1644
E +V+ + P + + +V + I S D FP + ++ + + ER
Sbjct: 71 TEDCEVDPSKCPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERG 130
Query: 1645 PE-YADIAVGSFLFLRFFCPALVSPDSEEIV-DSLTPKARKSSMSLAKVIQNIAN 1697
E V + LFLR CPA+++P + D P ++ +AKVIQN+AN
Sbjct: 131 SEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLAN 185
>7293383 [R] KOG3508 GTPase-activating protein
Length = 1436
Score = 64.7 bits (156), Expect = 2e-09
Identities = 54/227 (23%), Positives = 102/227 (44%), Gaps = 7/227 (3%)
Query: 1512 LASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGMDYLS 1571
+ ++V + A +T++V ++ R NS AT+++ +L G YL
Sbjct: 334 IGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQ 393
Query: 1572 NILKPILEELINSKECFDVEKLDPNDVDA---PRNLMLFKKYMTKVVDAITGSVDSFPPQ 1628
+ L + ELI S+ +V+ + A R + + I S FP Q
Sbjct: 394 DTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQ 453
Query: 1629 FFVICQAIHSSASERF--PEYADIAVGSFLFLRFFCPALVSPDSEEIVDSL-TPKARKSS 1685
C A ++ + AD + + +FLRF CPA++SP I L + +A ++
Sbjct: 454 -LRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNL 512
Query: 1686 MSLAKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSDK 1732
+AK +Q +AN + K +E ++FL+ + ++ +FL ++S +
Sbjct: 513 TLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTR 559
>Hs5901958 [T] KOG2059 Ras GTPase-activating protein
Length = 826
Score = 63.9 bits (154), Expect = 4e-09
Identities = 49/207 (23%), Positives = 95/207 (45%), Gaps = 21/207 (10%)
Query: 1512 LASSIVYFFDVKNAAHIIVTELVREEIGNATRHMEILRRNSCATRALSMLARLKGMDYLS 1571
+A++++ F + A + L + E+ + + R NS A++++ ++ GM YL
Sbjct: 329 VATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLH 388
Query: 1572 NILKPILEELINSKEC--FDVEKLDPNDVDA-------------PRNLMLFKKYMTKVVD 1616
+L PI+ ++ K+ D K++ DV ++ + ++ ++
Sbjct: 389 GVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLS 448
Query: 1617 AITGSVDSFPPQFFVICQAIHSSASERFP-----EYADIAVGSFLFLRFFCPALVSPDSE 1671
A++ SV + P + + ERFP IAV SFL LRFF PA++SP
Sbjct: 449 ALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLF 508
Query: 1672 EIVD-SLTPKARKSSMSLAKVIQNIAN 1697
+ + + ++ + LAK +QN+ N
Sbjct: 509 HLRERHADARTSRTLLLLAKAVQNVGN 535
>Hs4758808 [R] KOG3508 GTPase-activating protein
Length = 1139
Score = 63.5 bits (153), Expect = 5e-09
Identities = 54/225 (24%), Positives = 101/225 (44%), Gaps = 3/225 (1%)
Query: 1510 DALASSIVYFFDVKNAAHIIVTELVREEIGNATRH-MEILRRNSCATRALSMLARLKGMD 1568
+ LA ++V+ A +T+LV E+ H + I R N+ AT+++ +L G
Sbjct: 329 EELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQ 388
Query: 1569 YLSNILKPILEELINSKECFDVEKLDPNDVDAPRNLMLFKKYMTKVVDAITGSVDSFPPQ 1628
YL + L ++ L S E +V+ + + + K I S FP +
Sbjct: 389 YLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRE 448
Query: 1629 FFVICQAIHSSASER-FPEYADIAVGSFLFLRFFCPALVSPDSEEIVDSLTPKARKSSMS 1687
+ + R + ++ + + LFLRF CPA++SP ++ +++
Sbjct: 449 LKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLT 508
Query: 1688 L-AKVIQNIANGSVNSIKWKILESESEFLKNCSNKIFEFLSVVSD 1731
L AKVIQN+AN + K + + ++FL++ + FL +S+
Sbjct: 509 LIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN 553
>Hs4506787 [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 1657
Score = 59.3 bits (142), Expect = 9e-08
Identities = 67/312 (21%), Positives = 124/312 (39%), Gaps = 55/312 (17%)
Query: 1473 NRTKRKRDEIVEEVVLMTLKRPTLLSKACRICPASDIDALASSIVYFFDVKNAA------ 1526
++ KR++ E + + + PT L+K P + S++ F + N A
Sbjct: 962 SKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVI--FTLYNYASNQREE 1019
Query: 1527 ----HIIVTELVREEIGNATRHMEILRRNSCATRALSMLAR-LKGMDYLSNILKPILEEL 1581
+ T L E + EI+ N + + R +G + L IL P+++E+
Sbjct: 1020 YLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEI 1079
Query: 1582 INSKEC------FDVEKLDPNDVDA-------------PRNLMLFKKYMT---------- 1612
++ K D+ K N +++ P + ++ T
Sbjct: 1080 MDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMR 1139
Query: 1613 ----KVVDAITGSVDSFPPQFFVICQAIHSSASERFPEYADIA----VGSFLFLRFFCPA 1664
K + AI SVD P I + + S E+FP+ + +G+ L+ R+ PA
Sbjct: 1140 AVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPA 1199
Query: 1665 LVSPDSEEIVD-----SLTPKARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNCS 1719
+V+PD+ +I+D LT R++ S+AK++Q+ A+ + L +E+L
Sbjct: 1200 IVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSY 1259
Query: 1720 NKIFEFLSVVSD 1731
K F D
Sbjct: 1260 QKFRRFFQTACD 1271
>Hs5729887 [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 1575
Score = 57.4 bits (137), Expect = 3e-07
Identities = 63/306 (20%), Positives = 128/306 (41%), Gaps = 60/306 (19%)
Query: 1471 SNNRTKRKRDEIVEEVVLMTLKRPTLLSKACRICPASDIDALASSIVY----FFDVKNAA 1526
S ++ +RK E +++ + P L+K P + ++++ + +
Sbjct: 873 SLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREE 932
Query: 1527 HIIV----TELVREEIGNATRHMEILRRNSCATRALSMLAR-LKGMDYLSNILKPILEEL 1581
++++ T L E + +I+ N + + R +G + L +L P+++E+
Sbjct: 933 YLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEI 992
Query: 1582 INSKECF---------------------DVEKLDPNDVDAPRNLML-------------F 1607
I+ K + KL P DV + L
Sbjct: 993 IDDKSLIINTNPVEVYKAWVNQLETQTGEASKL-PYDVTTEQALTYPEVKNKLEASIENL 1051
Query: 1608 KKYMTKVVDAITGSVDSFPPQFFVICQAIHSSASERFPEYADIA----VGSFLFLRFFCP 1663
++ KV+++I S+D P I + + +S E+FP+ + VG+ L+ R+ P
Sbjct: 1052 RRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNP 1111
Query: 1664 ALVSPDSEEIVD-----SLTPKARKSSMSLAKVIQNIANGSVNSIKWKILESESEFLKNC 1718
A+V+PD +I+D + R++ S+AKV+Q+ A+ K+ E E+E L +
Sbjct: 1112 AIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASN-------KLFEGENEHLSSM 1164
Query: 1719 SNKIFE 1724
+N + E
Sbjct: 1165 NNYLSE 1170
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.322 0.136 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 154,865,240
Number of Sequences: 60738
Number of extensions: 6362960
Number of successful extensions: 17002
Number of sequences better than 1.0e-05: 27
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 16886
Number of HSP's gapped (non-prelim): 56
length of query: 2889
length of database: 30,389,216
effective HSP length: 124
effective length of query: 2765
effective length of database: 22,857,704
effective search space: 63201551560
effective search space used: 63201551560
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)