ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV5416 good YU KOG2171 Intracellular trafficking, secretion, and vesicular transport Karyopherin (importin) beta 3
r_klactV5416 good YU KOG2171 Nuclear structure Karyopherin (importin) beta 3
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV5416 1852044 1848706 -1113
(1113 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YER110c [YU] KOG2171 Karyopherin (importin) beta 3 1474 0.0
SPBC14F5.03c [YU] KOG2171 Karyopherin (importin) beta 3 531 e-150
At5g19820 [YU] KOG2171 Karyopherin (importin) beta 3 189 2e-47
At4g27640 [YU] KOG2171 Karyopherin (importin) beta 3 188 4e-47
Hs18874099 [YU] KOG2171 Karyopherin (importin) beta 3 160 8e-39
7296831 [YU] KOG2171 Karyopherin (importin) beta 3 147 7e-35
Hs21361131 [YU] KOG2171 Karyopherin (importin) beta 3 140 1e-32
HsM4504909 [YU] KOG2171 Karyopherin (importin) beta 3 138 6e-32
YMR308c [YU] KOG2171 Karyopherin (importin) beta 3 135 3e-31
SPCC1840.03 [YU] KOG2171 Karyopherin (importin) beta 3 108 6e-23
CE26971 [YU] KOG2171 Karyopherin (importin) beta 3 106 2e-22
YLR347c [YU] KOG1241 Karyopherin (importin) beta 1 64 2e-09
YGL195w [J] KOG1242 Protein containing adaptin N-terminal region 62 5e-09
SPAC2F3.06c [YU] KOG2023 Nuclear transport receptor Karyopherin-... 55 8e-07
Hs16161756 [YU] KOG2171 Karyopherin (importin) beta 3 54 1e-06
>YER110c [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1113
Score = 1474 bits (3816), Expect = 0.0
Identities = 750/1114 (67%), Positives = 911/1114 (81%), Gaps = 2/1114 (0%)
Query: 1 MDQQFVAQLEQALGAIVQPTGSLKDATKTLQSQFYTQSAALPALIHILQNSSNDGIKQLA 60
MDQQF++QLEQ L AI G LK+ATKTLQ+QFYTQ LPALIHILQN S+D +KQLA
Sbjct: 1 MDQQFLSQLEQTLHAITSGVG-LKEATKTLQTQFYTQPTTLPALIHILQNGSDDSLKQLA 59
Query: 61 GVEARKQVSKHWGSLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELDEKKW 120
GVEARK VSKHW ++D +T+ S+K SLL +AF+E K+ VRH+NARVIASIG+EELD KW
Sbjct: 60 GVEARKLVSKHWNAIDESTRASIKTSLLQTAFSEPKENVRHSNARVIASIGTEELDGNKW 119
Query: 121 PELIPNLLQAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLET 180
P+L+PNL+Q A + + R+TAIFI+ SLLE F ++L+ HIDDFL LF+QTIND +SLE
Sbjct: 120 PDLVPNLIQTASGEDVQTRQTAIFILFSLLEDFTSSLSGHIDDFLALFSQTINDPSSLEI 179
Query: 181 RSLSAQALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCLN 240
RSLSAQAL++VS+LIEE+ INP A KFA+ IPSVV VLDA I+ DT N KLIFNCLN
Sbjct: 180 RSLSAQALNHVSALIEEQETINPVQAQKFAASIPSVVNVLDAVIKADDTMNAKLIFNCLN 239
Query: 241 DFLLLDSQLTGNTIADLVKLALQIAVNSDVDEDIRVFAVQFVTSALVYRKSKINQAKLGP 300
DFLLLDSQLTGN I DL+KL+LQIAVNS++DED+RVFA+QF+ S+L YRKSK++Q+KLGP
Sbjct: 240 DFLLLDSQLTGNFIVDLIKLSLQIAVNSEIDEDVRVFALQFIISSLSYRKSKVSQSKLGP 299
Query: 301 EITLAALKVASEEIDVEDELTNEDEAGENEENTPALTALRLISNASGELSPSQVGVPIIE 360
EIT+AALKVA EEIDV+DEL NEDE GENEENTP+ +A+RL++ AS EL PSQV I+E
Sbjct: 300 EITVAALKVACEEIDVDDELNNEDETGENEENTPSSSAIRLLAFASSELPPSQVASVIVE 359
Query: 361 HLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVTGLKDSEAVVQLAALK 420
H+P ML S+N FERR+ILLAISV VTGSPDY LSQFDKIIPAT+ GLKD+E +V+LAALK
Sbjct: 360 HIPAMLQSANVFERRAILLAISVAVTGSPDYILSQFDKIIPATINGLKDTEPIVKLAALK 419
Query: 421 CIVQLSTNLQDEVARYHEQYLPLVIDIIDSAKHVVIYKYATLALDGLLEFIAHNDIIKYL 480
CI QL+T+LQDEVA++HE+YLPL+IDIIDSAK++VIY YAT+ALDGLLEFIA++ I KYL
Sbjct: 420 CIHQLTTDLQDEVAKFHEEYLPLIIDIIDSAKNIVIYNYATVALDGLLEFIAYDAIAKYL 479
Query: 481 DPLMNKLFQMLETQQSPKLRAAIVSAIGSCAFAAGSGFVPYFKTSVQYLQQFIQNVSQIE 540
DPLMNKLF MLE+ +S KLR A+VSAIGS AFAAGS F+PYFKTSV YL++FIQN SQIE
Sbjct: 480 DPLMNKLFYMLESNESSKLRCAVVSAIGSAAFAAGSAFIPYFKTSVHYLEKFIQNCSQIE 539
Query: 541 GLSEDDIELKALTFENISTMGRAVKSAAFAEYAEPLVNAAYEAIKTDSARLRESGYAFIA 600
G+SEDDIEL+A TFENISTM RAV+S AFAE+AEPLVN+AYEAIKTDSARLRESGYAFIA
Sbjct: 540 GMSEDDIELRANTFENISTMARAVRSDAFAEFAEPLVNSAYEAIKTDSARLRESGYAFIA 599
Query: 601 NMAKVYGKDFAPFLQTIIPEIFKTLEQEEYQFN-XXXXXXXXXXXXXXXXXXXQSKFTVN 659
N+AKVYG++FAPFL+TI+PEIFKTLE +EYQFN Q+KFTVN
Sbjct: 600 NLAKVYGENFAPFLKTILPEIFKTLELDEYQFNFDGDAEDLAAFADSANEEELQNKFTVN 659
Query: 660 TGIAYXXXXXXXXXXXXXXXXXXHFLEYVEPSLKVLAEQVNESYGLKETALHSMWAIVKA 719
TGI+Y HFL YVE SLKVL EQV+ESYGL+ETAL+++W +VK+
Sbjct: 660 TGISYEKEVASAALSELALGTKEHFLPYVEQSLKVLNEQVDESYGLRETALNTIWNVVKS 719
Query: 720 VLLTANLKEGEYPKGVPSGSYVDASALAVIQTVREVSLNNVIEEVETSMVISVFQDLSEM 779
VLL + ++ YPKG+P+ SYV+A LAVIQ RE S+ N+ +E ETSMVI+V +D + M
Sbjct: 720 VLLASKVEPESYPKGIPASSYVNADVLAVIQAARETSMGNLSDEFETSMVITVMEDFANM 779
Query: 780 LRLFGPIIIMDNGDSTHLDQLCREALSVLKGEHACQTIHFEEDVPEDEDLDASETEATLL 839
++ FG IIIMDNGDS+ L+ LC + LSVLKG H CQTI EEDVP DE+LDASETEATL
Sbjct: 780 IKQFGAIIIMDNGDSSMLEALCMQVLSVLKGTHTCQTIDIEEDVPRDEELDASETEATLQ 839
Query: 840 DVALDIYVALSTNLVGGFAQVFTTAKPVILQLCQSKSKNKRSFAVGALSEIALGMRDENP 899
DVAL++ V+LS L G FA+VF +PV+ L QSKSKNKRS AVGA SE+ALGM+++NP
Sbjct: 840 DVALEVLVSLSQALAGDFAKVFDNFRPVVFGLFQSKSKNKRSSAVGAASELALGMKEQNP 899
Query: 900 FIQELLEALIISLTNDKSLEVRCNASYGVGLLIEYSSFDVSAIYSPVLKSLYEILSVADE 959
F+ E+LEAL+I LT+DKSLEVR NA+YGVGLL EY+S D+SA+Y PVLK+LYE+LS AD+
Sbjct: 900 FVHEMLEALVIRLTSDKSLEVRGNAAYGVGLLCEYASMDISAVYEPVLKALYELLSAADQ 959
Query: 960 KNLATEDDEATKEIVDRTFSNVCGCVARMILKHQNLVPLEHTIPALLSHLPFNTAFEEYD 1019
K LA EDDEAT+EI+DR ++N GCVARM LK+ LVPLE T+PALL+HLP NT FEEY+
Sbjct: 960 KALAAEDDEATREIIDRAYANASGCVARMALKNSALVPLEQTVPALLAHLPLNTGFEEYN 1019
Query: 1020 PIFKLFLKLFQEQNSTIINEAPKVIAIFATVFEKESERIELETNSTLGREENLEKRKQFQ 1079
PIF+L +KL+QE + I NE P++I IF+ VF KE++RI+LE STLGREEN+E+ KQFQ
Sbjct: 1020 PIFELIMKLYQENSPVITNETPRIIEIFSAVFTKENDRIKLEKESTLGREENMERLKQFQ 1079
Query: 1080 SEEIKQQVIELLKHLNQQFNGAVAQNPVLAQVIA 1113
+EE+K +VIELLK+LN +NG VAQNPVLA VIA
Sbjct: 1080 TEEMKHKVIELLKYLNTTYNGIVAQNPVLAAVIA 1113
>SPBC14F5.03c [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1067
Score = 531 bits (1369), Expect = e-150
Identities = 329/1132 (29%), Positives = 578/1132 (50%), Gaps = 86/1132 (7%)
Query: 1 MDQQFVAQLEQALGAIVQP-TGSLKDATKTLQSQFYTQSAALPALIHILQNSSNDGIKQL 59
MD QF +L Q L + P T + +AT+ L++++ + +L +L HI+ N ++QL
Sbjct: 1 MDAQFTLELTQLLFQSIAPDTTQITEATRALETKYLKEPGSLLSLFHIMGTCENPQVRQL 60
Query: 60 AGVEARKQVSKHWGSLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELDEKK 119
A +EARK K+W S+DA Q ++ +LL+ E + VRHA RVIA++ +L E K
Sbjct: 61 AAIEARKLCHKYWSSVDADVQNQIRSNLLDITLKEPESIVRHAFGRVIAALAKLDLPEGK 120
Query: 120 WPELIPNLLQAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLE 179
W EL L+QA D N IRE A++++ S+ E+ + + L + DF+NLF+QTI DS S
Sbjct: 121 WNELSAFLVQATMDQNDSIREMAVYVLYSIAETVDLDNKLLL-DFVNLFSQTITDS-SRT 178
Query: 180 TRSLSAQALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCL 239
R S Q L ++ ++E + + + + + +P ++ VL ++ GD +K +F+
Sbjct: 179 VRVTSVQGLGAIAEVLESD---DKKLLHAYRATLPGMLLVLQDVVQVGDVDASKQVFDVF 235
Query: 240 NDFLLLDSQLTGNTIADLVKLALQIAVNSDVDEDIRVFAVQFVTSALVYRKSKINQAKLG 299
N FL+ + + +++++ IA + VD++IR A+ F+ S + ++ K+ KLG
Sbjct: 236 NTFLIASGAIISKALGNIIEIITGIANSKQVDDEIRCMALSFIISCIRFKSRKLQALKLG 295
Query: 300 PEITLAALKVASEEIDVEDELTNEDEAGENEENTPALTALRLISNASGELSPSQVGVPII 359
+ L ++VA+EE T +D +E+ PA ALR I S LSPSQV P+
Sbjct: 296 KPLVLTLMEVATEE-------TTDD----IDEDCPARLALRSIDLLSTHLSPSQVFYPMF 344
Query: 360 EHLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVTGLKDSEAVVQLAAL 419
E S R++ LL+I V V GS + I P + GL D++ V+ AAL
Sbjct: 345 EAACAFSQSPQASYRKAALLSIGVAVEGSSESVAGNLPNIFPIIINGLCDNDMDVRQAAL 404
Query: 420 KCIVQLSTNLQDEVARYHEQYLPLVIDIIDSAKHVVIYKYATLALDGLLEFIAHNDIIKY 479
+ Q++ + EV+++H Q LPLV +++ S + V + K A +D LLE + ++I Y
Sbjct: 405 LALSQIAVEIPTEVSKHHAQLLPLVFELM-STQGVKVGKSACNCIDALLEGLDKSEISGY 463
Query: 480 LDPLMNKLFQMLETQQSPKLRAAIVSAIGSCAFAAGSGFVPYFKTSVQYLQQFIQNVSQI 539
L LM +L +LE +P +++ + +AIGS AFAA F+PYF+ ++ L Q +
Sbjct: 464 LPMLMERLVGLLEFSDTPDIKSCVAAAIGSAAFAAQDDFIPYFERTMASLSQCLHTTDDD 523
Query: 540 EGLSEDDIELKALTFENISTMGRAVKSAAFAEYAEPLVNAAYEAIKTDSARLRESGYAFI 599
EG EL+ + + + AV AF Y E L+ AYE I+ D +RLRE + F
Sbjct: 524 EG-----YELRGTVMDTLGAIANAVGKQAFLPYTEQLIQLAYEGIQIDHSRLRECSFCFY 578
Query: 600 ANMAKVYGKDFAPFLQTIIPEIFKTLEQEEYQFNXXXXXXXXXXXXXXXXXXXQSK---- 655
A +A+VY ++FAPFL+ I+P +FK+++Q+E ++
Sbjct: 579 AVLARVYKEEFAPFLEHIVPALFKSIDQDESDILSERIGAPTAEEISQLLDSVETNEEEN 638
Query: 656 -------FTVNTGIAYXXXXXXXXXXXXXXXXXXHFLEYVEPSLKVLAEQVNESY-GLKE 707
VN+ IA F Y+EP+++ L Y G+++
Sbjct: 639 DEELEKAMGVNSAIAMEKEIAADALGEICMYVGAPFTPYLEPTVEKLVACTTHFYEGVRK 698
Query: 708 TALHSMWAIVKAVLLTANLKEGEYPKGVPSGSYVDASALAVIQTVREVSLNNVIEEVETS 767
+AL S+W N+ ++ G+P V + + + VR+ + + + EE E +
Sbjct: 699 SALSSLWRCATTYYKVCNVP--QWQPGLPLKVPVPDTVKNIFEAVRKCTFDTLEEEYEKT 756
Query: 768 MVISVFQDLSEMLRLFGPIIIMDNGDSTHLDQLCREALSVLKGEHACQTIHF------EE 821
+ + ++ +E ++ GP+++ D+ ++LC + VL+ +H Q EE
Sbjct: 757 VATDILRNFAESIKTCGPVVLGDD-----YEKLCEVVMEVLQKQHIVQAGDVFDDDFEEE 811
Query: 822 DVPEDEDLDASETEATLLDVALDIYVALSTNLVGGFAQVFTTAKPVILQLCQSKSKNKRS 881
D+ +E++D +E +A L+D A D+ +AL+ L G FA F P I++ SK+ N+R+
Sbjct: 812 DIVSNEEVDDTEQDALLIDSACDVVIALAVALGGSFADSFKVFYPQIVKYYMSKNGNERA 871
Query: 882 FAVGALSEIALGMRDE-NPFIQELLEALIISLTNDKSLEVRCNASYGVGLLIEYSSFDVS 940
AV + E+A G+ PF +++ +L ++ D EVR NA+Y +GLL ++S+ D+S
Sbjct: 872 MAVACVGEVAGGIESAITPFTRDVF-SLFMAALEDSEGEVRSNAAYSMGLLCQFSTEDLS 930
Query: 941 AIYSPVLKSLYEILSVADEKNLATEDDEATKEIVDRTFSNVCGCVARMILKHQNLVPLEH 1000
+ Y +L+ L T+E+ N GC++R+IL +QN +P++
Sbjct: 931 SEYLNILQKLQPFF---------------TQEVFRTALDNAIGCISRLILHNQNAIPVDQ 975
Query: 1001 TIPALLSHLPFNTAFEEYDPIFKLFLKLFQEQNSTIINEAPKVIAIFATVFEKESERIEL 1060
+P + S LP + E P++ + L L+++QN ++ ++I +FA+V E++
Sbjct: 976 VLPIVFSKLPLKEDYLENAPLYHMILALYRQQNPCLVQHLGELIPVFASVLTGSPEQL-- 1033
Query: 1061 ETNSTLGREENLEKRKQFQSEEIKQQVIELLKHLNQQFNGAVAQNPVLAQVI 1112
++E++ +++ ++K + Q+ V+ P L ++
Sbjct: 1034 -------------------NDELRSELLSMVKEIAPQYESVVSNYPQLVALL 1066
>At5g19820 [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1116
Score = 189 bits (480), Expect = 2e-47
Identities = 212/1075 (19%), Positives = 450/1075 (41%), Gaps = 89/1075 (8%)
Query: 44 LIHILQNSSNDGIKQLAGVEARKQVSKH----WGSLDAATQTSVKQSLLNSAFNEGKDAV 99
L H+LQ S + + +A V RK +++ W L +TQ+S+K S+L +E ++
Sbjct: 61 LAHLLQLSPHPEGRAMAAVLLRKLLTRDDAYLWPRLSLSTQSSLKSSMLYCIQHEEAKSI 120
Query: 100 RHANARVIASIGSEELDEKKWPELIPNLLQAACDSNPKIRETAIFIILSLLESFNANLAL 159
++ + S L E WPEL+P + Q PK++E+A I+ L + L
Sbjct: 121 SKKICDTVSELASGILPENGWPELLPFVFQCVTSVTPKLQESAFLILAQLSQYVGETLTP 180
Query: 160 HIDDFLNLFAQTI-NDSASLETRSLSAQA-LSYVSSLIEEEGEINPQYAAKFASLIPSVV 217
HI + +F Q + ++SAS + + + A +S+V L N +F ++P+++
Sbjct: 181 HIKELHGVFLQCLSSNSASSDVKIAALNAVISFVQCL------ANSTERDRFQDVLPAMI 234
Query: 218 QVLDATIREGDTTNTKLIFNCLNDFLLLDSQLTGNTIADLVKLALQIAVNSDVDEDIRVF 277
+ L ++ G+ + L + + + + D+V LQIA ++E R
Sbjct: 235 RTLTESLNNGNEATAQEALELLIELAGTEPRFLRRQLVDIVGSMLQIAEADSLEESTRHL 294
Query: 278 AVQFVTSALVYRKSKINQAKLGPEITLAALKVASEEI-DVEDE------LTNEDEAGENE 330
A++F+ + R+ + P+ V + + D+ED+ T +++AGE
Sbjct: 295 AIEFLVTLAEARERAPGMVRKLPQFIDRLFAVLMKMLEDIEDDPAWYSAETEDEDAGETS 354
Query: 331 ENTPALTALRLISNASGELSPSQVGVPI-IEHLPTMLSSSNPFERRSILLAISVLVTGSP 389
+ L ++ + G VP+ + L++S + + L+A++ + G
Sbjct: 355 NYSMGQECLDRLAISLG----GNTIVPVAYQQFSAYLAASEWQKHHASLIALAQIAEGCS 410
Query: 390 DYTLSQFDKIIPATVTGLKDSEAVVQLAALKCIVQLSTNLQDEVA-RYHEQYLPLVIDII 448
+ D+++ ++ + V+ AA+ I QLST+L ++ ++HE+ LP + +
Sbjct: 411 KVMIKNLDQVVSMVLSQFQSPHPRVRWAAINAIGQLSTDLGPDLQNQHHERVLPALAAAM 470
Query: 449 DSAKHVVIYKYATLALDGLLEFIAHNDIIKYLDPLMNKLFQMLETQQSPKLRAAIVSAIG 508
D ++ + +A A+ E + YLD +++KL +L+ + ++ ++A+
Sbjct: 471 DDFQNPRVQAHAASAVLNFSENCTPEILSPYLDGVVSKLLVLLQNGKQ-MVQEGALTALA 529
Query: 509 SCAFAAGSGFVPYFKTSVQYLQQFIQNVSQIEGLSEDDIELKALTFENISTMGRAVKSAA 568
S A ++ F Y+ T + YL+ + N + + L+A + E IS +G AV
Sbjct: 530 SVADSSQEHFQKYYDTVMPYLKTILMNAT-----DKSKRMLRAKSMECISLVGMAVGKDR 584
Query: 569 FAEYA----EPLVNAAYEAIKTDSARLRESGYAFIANMAKVYGKDFAPFLQTIIPEIFKT 624
F E A E L++ ++ D A+ A + K G+DF P+++ ++P + ++
Sbjct: 585 FKEDARQVMEVLMSLQGSQMEADDPITSYMLQAW-ARLCKCLGQDFLPYMKVVMPPLLQS 643
Query: 625 LEQEE----YQFNXXXXXXXXXXXXXXXXXXXQSKFTVNTGIAYXXXXXXXXXXXXXXXX 680
+ + + + + T +
Sbjct: 644 AQLKPDVTITSADSEDEAEDSDDESMETIILGDKRIGIKTSVLEEKATACNMLCCYADEL 703
Query: 681 XXHFLEYVEPSLKVLAEQVNESY--GLKETALHSMWAIVKAVLLTANLKEGEYPKGVPSG 738
F +++ L + + ++ A+ +M ++++ L KG G
Sbjct: 704 KEGFFPWIDQVAPTLVPLLKFYFHEEVRRAAVSAMPELMRSAKLAIE-------KGESQG 756
Query: 739 ---SYVDASALAVIQTVREVSLNNVIEEVETSMVISVFQDLSEMLRLFGPIIIMDNGDST 795
SY+ + +I + E + +E +T + +S+ + ++E L++ G ++D G
Sbjct: 757 RDLSYLKQLSDYIIPAMLEA----LHKEPDTEICVSMLEAINECLQISGN--LLDEGKIR 810
Query: 796 HLDQLCREALSVL------KGEHACQTIHFEEDVPEDEDL--DASETEATLLDVALDIYV 847
+ ++ ++ +GE A H E+ E+ +L + +E E + D +I
Sbjct: 811 SIVDEIKQVMTASSSRKRERGERA----HAEDFDAEEGELIKEENEQEEEIFDQVGEILG 866
Query: 848 ALSTNLVGGFAQVFTTAKPVILQLC-QSKSKNKRSFAVGALSEIALGMRDENPFIQELLE 906
L F F + + + K+ +R A+ ++A R+ +
Sbjct: 867 TLVKTFKASFLPFFDELSSYLTPMWGRDKTAEERRIAICIFDDVAEQCREAAFKYYDTYL 926
Query: 907 ALIISLTNDKSLEVRCNASYGVGLLIEYSSFDVSAIYSPVLKSLYEILSVADEKNLATED 966
++ ND+S EVR A YG+G+ E+ +++ P++ L+V + A +
Sbjct: 927 PFVLEACNDESPEVRQAAVYGLGVCAEFG----GSVFKPLIGEALSRLNVVIQLPNARQS 982
Query: 967 DEATKEIVDRTFSNVCGCVARMILKHQNLVPLEHTIPALLSHLPFNTAFEEYDPIFKLFL 1026
+ A + N V ++ H++ + +PA L+ LP + E +
Sbjct: 983 ENA------MAYDNAVSAVGKICQFHRDSIDSSQVLPAWLNCLPISNDVLEAKVVHDQLC 1036
Query: 1027 KLFQEQNSTII----NEAPKVIAIFATVFEKESERIELETNSTLGREENLEKRKQ 1077
+ + Q+ ++ PK++ +FA V + ++ T T GR N+ ++ Q
Sbjct: 1037 SMVERQDVDLLGPNNQHLPKILIVFAEVLTGK----DVVTQETAGRMINILRQLQ 1087
>At4g27640 [YU] KOG2171 Karyopherin (importin) beta 3
Length = 651
Score = 188 bits (478), Expect = 4e-47
Identities = 153/622 (24%), Positives = 281/622 (44%), Gaps = 47/622 (7%)
Query: 9 LEQALGAIVQPTGSLKDATKTLQSQFYTQSAALPALIHILQNSSNDGIKQLAGVEARKQV 68
LE L + P + + + +PAL+ L+ + ++QLA V RK++
Sbjct: 5 LELLLIQFLMPDNDARRQAEDQIKRLAKDPQVVPALVQHLRTAKTPNVRQLAAVLLRKRI 64
Query: 69 SKHWGSLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELDEKKWPELIPNLL 128
+ HW L + VKQSL+ S E VR A+A V++ + + +WP+L+ L
Sbjct: 65 TGHWAKLSPQLKQHVKQSLIESITVENSPPVRRASANVVSVVAKYAVPAGEWPDLLTFLF 124
Query: 129 QAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLETRSLSAQAL 188
Q + + RE A+ + SL E+ + D L + + D +S R + +A+
Sbjct: 125 QCSQSAQEDHREVALILFSSLTETIGNTFRPYFADLQALLLKCMQDESSSRVRVAALKAV 184
Query: 189 SYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCLNDFLLLDSQ 248
+ E+ KF IPS++ V I G+ L F ++ + +
Sbjct: 185 GSFLEFTNDGDEV-----VKFRDFIPSILDVSRKCIASGEEDVAILAFEIFDELIESPAP 239
Query: 249 LTGNTIADLVKLALQIAVNSDVDEDIRVFAVQFVTSALVYRKSKINQAKLGPEITLAALK 308
L G+++ +V+ +L+++ N +++ R A+Q V+ Y+ + + + KL I
Sbjct: 240 LLGDSVKAIVQFSLEVSCNQNLESSTRHQAIQIVSWLAKYKYNSLKKHKLVIPILQVMCP 299
Query: 309 VASEEIDVEDELTNEDEAGENEENTPALTALRLISNASGELSPSQVGVPIIEHLPTMLSS 368
+ +E D ED+ ++ P + +I + L P V +P++E S
Sbjct: 300 LLAESSDQEDD----------DDLAPDRASAEVIDTLAMNL-PKHVFLPVLEFASVHCQS 348
Query: 369 SNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVTGLKDSEAVVQLAALKCIVQLSTN 428
+N R + + A+ V+ G D + D ++ + L+D E VV+ AA I Q + +
Sbjct: 349 TNLKFREASVTALGVISEGCFDLMKEKLDTVLNIVLGALRDPELVVRGAASFAIGQFAEH 408
Query: 429 LQDEVARYHEQYLPLVIDIIDSAKHVVIYKYATLALDGLLEFIAHNDIIKYLDPLMNKLF 488
LQ E+ +++ LP ++ I+ V K + AL E + +I+ LD LM KL
Sbjct: 409 LQPEILSHYQSVLPCLLIAIEDTSEEVKEK-SHYALAAFCENMG-EEIVPLLDHLMGKLM 466
Query: 489 QMLETQQSPK-LRAAIVSAIGSCAFAAGSGFVPYFKTSVQYLQQFIQNVSQIEGLSEDDI 547
LE SP+ L+ +SAIGS A AA F PY + ++ ++ F+ L++D+
Sbjct: 467 AALE--NSPRNLQETCMSAIGSVAAAAEQAFNPYAERVLELMKFFMV-------LTKDE- 516
Query: 548 ELKALTFENISTMGRAVKSAAFAEYAEPLVNAAYEAIKTDSARLRESGYAFIANMAKVYG 607
+L+A RA K + L Y+ + + + LRE + F +N+A++
Sbjct: 517 DLRA----------RARK--------KELTITKYQGFELEFSELREYTHGFFSNVAEILD 558
Query: 608 KDFAPFLQTIIPEIFKTLEQEE 629
FA +L ++P +F + ++
Sbjct: 559 DTFAQYLPRVMPLVFASCNLDD 580
>Hs18874099 [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1081
Score = 160 bits (406), Expect = 8e-39
Identities = 150/638 (23%), Positives = 294/638 (45%), Gaps = 36/638 (5%)
Query: 7 AQLEQALGAIVQP-TGSLKDATKTLQSQFYTQSAALPALIHILQNSSNDGIKQLAGVEAR 65
A LEQ L ++ P T ++ AT+ LQ AALPAL +L ++++ I+Q A V R
Sbjct: 4 AGLEQLLRELLLPDTERIRRATEQLQIVLRAP-AALPALCDLLASAADPQIRQFAAVLTR 62
Query: 66 KQVSKHWGSLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELDEKKWPELIP 125
++++ W L A + S+K +L + E + V + A++ A+I +E E WP+L+
Sbjct: 63 RRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEA-WPQLLQ 121
Query: 126 NLLQAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLETRSLSA 185
L + + RE + ++ ++ S H + L L +T+ + S S
Sbjct: 122 LLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYSL 181
Query: 186 QALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCLNDFLLL 245
+ L+ ++ + E L+P ++ + I + + + L++ L
Sbjct: 182 RTLTTMAPYLSTED------VPLARMLVPKLIMAMQTLIPIDEAKACEAL-EALDELLES 234
Query: 246 DSQLTGNTIADLVKLALQIAVNSDVDEDIRVFAVQFVTSALVYRKSKINQAKLGPEITLA 305
+ + +++++ L++A N + IR+ + +T + + + + +L P +
Sbjct: 235 EVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHT 294
Query: 306 ALKVASEE-----IDVEDELTNEDEAG-ENEENTPALTALRLISNASGELSPSQVGVPII 359
+ + E +D ED+ + E+E E TP A++++ + L P ++ ++
Sbjct: 295 LFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLM 354
Query: 360 EHLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQF-DKIIPATVTGLKDSEAVVQLAA 418
L L S +P++R++ LL ++VL G+ D+ + ++ GL+D VV+ AA
Sbjct: 355 PMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAA 414
Query: 419 LKCIVQLSTNLQDEVARYHEQYLPLVIDIIDSAK--HVVIYKYATLALDGLLEFIAHNDI 476
L + Q S NLQ ++ Y + +PL++ + S H A AL+ +E + +
Sbjct: 415 LFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPK-V 473
Query: 477 IKYLDPLMNKLFQMLETQQSPKLRAAIVSAIGSCAFAAGSGFVPYFKTSVQYLQQFIQNV 536
YL LM + Q+L SP+ + VSA+G+ A AA +PYF +++L++F+
Sbjct: 474 QPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQVSLLPYFPAIMEHLREFLLTG 533
Query: 537 SQIEGLSEDDIELKALTFENISTMGRAVKSAAFAEYAEPLVNAAYE-----AIKTDSARL 591
+ +L+ + +++ T+G V + A E PL + + D A L
Sbjct: 534 RE---------DLQPVQIQSLETLG--VLARAVGEPMRPLAEECCQLGLGLCDQVDDADL 582
Query: 592 RESGYAFIANMAKVYGKDFAPFLQTIIPEIFKTLEQEE 629
R Y+ A ++ + G+ AP L+ I + +L E
Sbjct: 583 RRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTE 620
Score = 106 bits (264), Expect = 2e-22
Identities = 88/312 (28%), Positives = 150/312 (47%), Gaps = 27/312 (8%)
Query: 743 ASALAVIQTVREVSLNNVIEEVETSMVISVFQDLSEMLRLFGPIIIMDNGDSTHLDQLCR 802
A+ A + V + V E E +V++V + L+ +LR G + + G L +LC
Sbjct: 742 AALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPG---RLAELCG 798
Query: 803 EALSVLKGEHACQTIHFEEDVPEDEDLDASETEATLLDVALDIYVALSTNLVG-GFAQVF 861
+VL+ + ACQ EE E+ED D +E +A LL+ A + AL+ G FA F
Sbjct: 799 VLKAVLQRKTACQDTDEEE---EEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFF 855
Query: 862 TTAKPVILQLCQSK---SKNKRSFAVGALSEIALGMRDENPFIQELLEALIISLTNDKSL 918
P+++ C++K + ++SFAVG L+E G+ + L +++S +
Sbjct: 856 AGFLPLLV--CKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADP 913
Query: 919 EVRCNASYGVGLLIEYSSFDVSAIYSPVLKSLYEILSVADEKNLATEDDEATKEIVDRTF 978
EVR NA +G+G+L E+ + +L L+ +L+ +E DR
Sbjct: 914 EVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLA---------------RERHDRVR 958
Query: 979 SNVCGCVARMILKHQNLVPLEHTIPALLSHLPFNTAFEEYDPIFKLFLKLFQEQNSTIIN 1038
N+CG +AR+++ P + ALL LP EE+ I +LF L+Q +I+
Sbjct: 959 DNICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVID 1018
Query: 1039 EAPKVIAIFATV 1050
AP+++ I + +
Sbjct: 1019 VAPELLRICSLI 1030
>7296831 [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1105
Score = 147 bits (372), Expect = 7e-35
Identities = 212/1082 (19%), Positives = 424/1082 (38%), Gaps = 76/1082 (7%)
Query: 7 AQLEQALGAIVQPTGSLKDATKTLQSQFYTQSAALPALIHILQNSSNDGIKQLAGVEARK 66
A +Q L +++ ++ + + + L +I ++ +Q+A V R+
Sbjct: 6 AHFQQLLASLLSTDNDVRQQAEEAYNNLSRELKVTHLLGNIQNGQQSEEARQMAAVLLRR 65
Query: 67 QVSKH----WGSLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELDE---KK 119
+ + L A +Q + Q +L + E +R V+A + +DE +
Sbjct: 66 LFTTEFFDFYKGLPAESQNQLLQQILLAVQQEVTPQLRRKICEVVAEVARNLIDEDCNNQ 125
Query: 120 WPELIPNLLQAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLE 179
WP+++ L Q A P+++E+A+ I S+ F A +ID + A++++ + E
Sbjct: 126 WPDILQFLFQCANSPTPQLQESALRIFSSVPSIFGNQEAQYIDLIKQMLAKSMDAGSDPE 185
Query: 180 TRSLSAQALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIR-EGDTTNTKLIFNC 238
R + +A+ + ++ + E FA ++P ++ + TI + D + KL+
Sbjct: 186 VRVQAVRAVG--AFILYHDKENETAIHKHFADMLPRMIHITGETIEAQDDQSLLKLLIEM 243
Query: 239 LNDFLLLDSQLTGNTIADLVKLALQIAVNSDVDEDIRVFAVQFVTSALVYRKSKINQAKL 298
+ + + + ++ +++ + D ++ R ++ + S S I +
Sbjct: 244 TENC----PKFLRPQLEFIFEVCMKVFSSQDFEDSWRHLVLEVMVSLAENAPSMIRKRAD 299
Query: 299 GPEITLAALKV-ASEEIDVEDELTNEDEAGENEENTPALTALRLISNASGELSPSQVGVP 357
+ L L + ++D ++ + D +++ + + A + + L V
Sbjct: 300 KYIVALIPLILHMMTDLDDDENWSTADVVDDDDHSDNNVIAESSLDRLACGLGGKIVLPL 359
Query: 358 IIEHLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVTGLKDSEAVVQLA 417
++ LP ML ++ R + L+AIS + G + D+++ + L D V+ A
Sbjct: 360 VMNALPVMLGHADWKHRFAALMAISAIGEGCHKQMEAILDEVMSGVLNFLSDPHPRVRYA 419
Query: 418 ALKCIVQLSTNL-QDEVARYHEQYLPLVIDIIDSAKHVVIYKYATLALDGLLEFIAHNDI 476
A I Q+ST+ Q ++H Q +P ++ ++D ++ + +A AL E N +
Sbjct: 420 ACNAIGQMSTDFAQTFEKKFHSQVIPGLLSLLDDVENPRVQAHAGAALVNFSEDCPKNIL 479
Query: 477 IKYLDPLMNKL-------FQMLETQQSPKLRAAIVSAIGSCAFAAGSGFVPYFKTSVQYL 529
+YLD +M KL F+ L + + + +V+ I S A S FV Y+ + L
Sbjct: 480 TRYLDGIMAKLETILNSKFKELVEKGNKLVLEQVVTTIASVADTCESEFVAYYDRLMPCL 539
Query: 530 QQFIQNVSQIEGLSEDDIELKALTFENISTMGRAVKSAAFAEYAEP-----LVNAAYEAI 584
+ IQN + S+D L+ T E +S +G AV F A LVN
Sbjct: 540 KFIIQNAN-----SDDLRMLRGKTIECVSLIGLAVGREKFIGDAGEVMDMLLVNHTEGGE 594
Query: 585 KTDSARLRESGYAFIANMAKVYGKDFAPFLQTIIPEIFKTLEQE---EYQFNXXXXXXXX 641
D A M K+ GK F +L ++ + +T + N
Sbjct: 595 LADDDPQTSYLITAWARMCKILGKQFEQYLPLVMGPVMRTATMKPEVAMLDNDEVEDIDG 654
Query: 642 XXXXXXXXXXXQSKFTVNTGIAYXXXXXXXXXXXXXXXXXXHFLEYVEPSLKVLAEQVNE 701
Q F + T F EY E ++ + +
Sbjct: 655 DVDWSFINLGEQQNFAIRTAGMDDKASACEMLVCYARELKEGFAEYAEDVVRQMLPMLKF 714
Query: 702 SY--GLKETALHSMWAIVKAVLLTANLKEGEYPKGVPSGSYVDASALAVIQTVREVSLNN 759
+ G++ A S+ +L A +K +Y +G+ ++ L VI T
Sbjct: 715 YFHDGVRTAAAESL----PYLLDCAKIKGPQYLEGM--WMFICPELLKVIVT-------- 760
Query: 760 VIEEVETSMVISVFQDLSEMLRLFGPIIIMDNGDSTHLDQLCREALSVLKGEHACQTIHF 819
E E + + L++ + GP + ++ L+ + + L +
Sbjct: 761 ---EPEPDVQSELLNSLAKCIETLGPNCLNEDAMKQVLEIINKYVLEHFERADKRLAARN 817
Query: 820 EEDVP---EDEDLDASETEATLLDVALDIYVALSTNLVGGFAQVFTTAKPVILQLCQ-SK 875
EED E+E + +T+ +L +DI AL F F P ++L + S+
Sbjct: 818 EEDYDDGVEEELAEQDDTDVYILSKIVDITHALFQTNKAQFLPAFEQVAPHFVKLLEPSR 877
Query: 876 SKNKRSFAVGALSEIALGMRDENPFIQELLEALIISLTNDKSLEVRCNASYGVGLLIEYS 935
R + + ++ Q++ ++ DK+ EVR A+YG G+L +++
Sbjct: 878 PVADRQWGLCVFDDLIEFCGPACAPYQQIFTPALVQYVCDKAPEVRQAAAYGCGVLGQFA 937
Query: 936 SFDVSAIYSPVLKSLYEILSVADEKNLATEDDEATKEIVDRTFSNVCGCVARMILKHQN- 994
+ + ++ L ++++ D K E+ T+ N A+ ILK+ N
Sbjct: 938 GEQFAHTCAQIIPLLVQVIN--DPKAREIENISPTE--------NAISAFAK-ILKYNNS 986
Query: 995 -LVPLEHTIPALLSHLPFNTAFEEYDPIFKLFLKLFQEQNSTII----NEAPKVIAIFAT 1049
L ++ I S LP + EE I+ L + + I+ P++++I A
Sbjct: 987 ALSNVDELIGVWFSWLPVSEDSEEAAHIYGYLCDLIEGNHPVILGANNGNLPRIVSIIAE 1046
Query: 1050 VF 1051
F
Sbjct: 1047 SF 1048
>Hs21361131 [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1097
Score = 140 bits (352), Expect = 1e-32
Identities = 225/1082 (20%), Positives = 433/1082 (39%), Gaps = 99/1082 (9%)
Query: 13 LGAIVQPTGSLKDATKTLQSQFYTQSAALPALIHILQNSSNDGIKQLAGVEARKQVSKHW 72
LG ++ P ++ + QS L I ++ + +Q+A V R+ +S +
Sbjct: 15 LGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAF 74
Query: 73 G----SLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELDE---KKWPELIP 125
+L + QT++K LL E + ++R + A + +DE +WPE +
Sbjct: 75 DEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLIDEDGNNQWPEGLK 134
Query: 126 NLLQAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLETRSLSA 185
L + N +RE A+ I + F ++D + Q + D R+LSA
Sbjct: 135 FLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSA 194
Query: 186 QALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCLNDFLLL 245
+A ++ E N FA L+P +Q ++ + + D + K + + +
Sbjct: 195 RA----TAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLVEIADT---V 247
Query: 246 DSQLTGNTIADLVKLALQIAVNSDVDEDIRVFAVQFV-----TSALVYRKSKINQAKLGP 300
L + A L +L+L++ ++ ++ R A++ + T+A + RK A+ P
Sbjct: 248 PKYLRPHLEATL-QLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIP 306
Query: 301 EITLAALKVASEEIDVEDELTNEDEAGENEENTPALTALRLISNASGELSPSQVGVPIIE 360
+ + A+ V EE +++ N DE +++ ++ A+ + + L V I E
Sbjct: 307 Q--MLAMMVDLEE---DEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKE 361
Query: 361 HLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVTGLKDSEAVVQLAALK 420
H+ ML + + R + L+A+S + G ++I+ + L+D V+ AA
Sbjct: 362 HIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACN 421
Query: 421 CIVQLSTNLQDEV-ARYHEQYLPLVIDIIDSAKHVVIYKYATLALDGLLEFIAHNDIIKY 479
+ Q++T+ ++HE+ + ++ ++ + + +A AL E + +I Y
Sbjct: 422 AVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIPY 481
Query: 480 LDPLMNKLFQMLE------TQQSPKL-RAAIVSAIGSCAFAAGSGFVPYFKTSVQYLQQF 532
LD L+ L ++ Q+ KL +V++I S A A FVPY+ + L+
Sbjct: 482 LDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHI 541
Query: 533 IQNVSQIEGLSEDDIELKALTFENISTMGRAVKSAAFAEYAEPLV------NAAYEAIKT 586
++N Q E L+ T E IS +G AV F + A ++ + ++
Sbjct: 542 VENAVQKELRL-----LRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMED 596
Query: 587 DSARLRESGYAFIANMAKVYGKDFAPFLQTIIPEIFKT--LEQEEYQFNXXXXXXXXXXX 644
D ++ A+ A M K+ GK+F +L ++ + KT ++ E +
Sbjct: 597 DDPQISYMISAW-ARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDD 655
Query: 645 X-XXXXXXXQSKFTVNTGIAYXXXXXXXXXXXXXXXXXXHFLEYVEPSLKVLAEQVNESY 703
Q F + T F+EY E +K++ + +
Sbjct: 656 GWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYF 715
Query: 704 --GLKETALHSMWAIVKAVLLTANLKEGEYPKGVPSGSYVDASALAVIQTVREVSLNNVI 761
G++ A SM +L A ++ EY + + + +I
Sbjct: 716 HDGVRVAAAESM----PLLLECARVRGPEY-----------------LTQMWHFMCDALI 754
Query: 762 EEVETSMVISVFQDLSEMLRLFGPII-IMDNG--DSTHLDQLCREALSVL----KGEHAC 814
+ + T V LSE++ F I +M +G ++ H ++L + L K +
Sbjct: 755 KAIGTEPDSDV---LSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELR 811
Query: 815 QTIHFEEDVPE--DEDL-DASETEATLLDVALDIYVALSTNLVGGFAQVFTTAKPVILQL 871
Q +ED E +E L D + + +L DI ++ ++ F P+I+ L
Sbjct: 812 QVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNL 871
Query: 872 -CQSKSKNKRSFAVGALSEIALGMRDENPFIQELLEALIISLTNDKSLEVRCNASYGVGL 930
C + R + + ++ + E ++ D S EVR A+YG+G+
Sbjct: 872 ICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGV 931
Query: 931 LIEYSSFDVSAIYSPVLKSLYEILSVADEKNLATEDDEATKEIVDRTFSNVCGCVARMIL 990
+ +Y + + L L ++ AD K TKE V+ T N V +++
Sbjct: 932 MAQYGGDNYRPFCTEALPLLVRVIQSADSK---------TKENVNAT-ENCISAVGKIMK 981
Query: 991 KHQNLVPLEHTIPALLSHLPFNTAFEEYDPIFKLFLKLFQEQNSTII----NEAPKVIAI 1046
+ V +E +P LS LP + EE F L + + ++ PK+ +I
Sbjct: 982 FKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSI 1041
Query: 1047 FA 1048
A
Sbjct: 1042 IA 1043
>HsM4504909 [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1097
Score = 138 bits (347), Expect = 6e-32
Identities = 223/1082 (20%), Positives = 430/1082 (39%), Gaps = 99/1082 (9%)
Query: 13 LGAIVQPTGSLKDATKTLQSQFYTQSAALPALIHILQNSSNDGIKQLAGVEARKQVSKHW 72
LG ++ P ++ + QS L I ++ + +Q+A V R+ +S +
Sbjct: 15 LGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAF 74
Query: 73 G----SLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELDE---KKWPELIP 125
+L + QT++K LL E + ++R + A + +DE +WPE +
Sbjct: 75 DEVYPALPSDVQTAIKSELLMIIQMETQXSMRKKVCDIAAELARNLIDEDGNNQWPEGLK 134
Query: 126 NLLQAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLETRSLSA 185
L + N +RE A+ I + F ++D + Q + D R+LSA
Sbjct: 135 FLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSA 194
Query: 186 QALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCLNDFLLL 245
+A ++ E N FA L+P +Q ++ + + D + K + + +
Sbjct: 195 RA----TAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLVEIADT---V 247
Query: 246 DSQLTGNTIADLVKLALQIAVNSDVDEDIRVFAVQFV-----TSALVYRKSKINQAKLGP 300
L + A L +L+L++ ++ + R A++ + T+A + RK A+ P
Sbjct: 248 PKYLRPHLEATL-QLSLKLCGDTSXNNMQRQLALEVIVTXSETAAAMLRKHTNIVAQTIP 306
Query: 301 EITLAALKVASEEIDVEDELTNEDEAGENEENTPALTALRLISNASGELSPSQVGVPIIE 360
+ + A+ V EE +++ N DE +++ ++ A+ + + L V I E
Sbjct: 307 Q--MLAMMVDLEE---DEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKE 361
Query: 361 HLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVTGLKDSEAVVQLAALK 420
H+ ML + + R + L+A+S + G ++I+ + L+D V+ AA
Sbjct: 362 HIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACN 421
Query: 421 CIVQLSTNLQDEV-ARYHEQYLPLVIDIIDSAKHVVIYKYATLALDGLLEFIAHNDIIKY 479
+ Q++T+ ++HE+ + ++ ++ + + +A AL E + +I Y
Sbjct: 422 AVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIPY 481
Query: 480 LDPLMNKLFQMLE------TQQSPKL-RAAIVSAIGSCAFAAGSGFVPYFKTSVQYLQQF 532
LD L+ L ++ Q+ KL +V++I S A A FVPY+ + L+
Sbjct: 482 LDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHI 541
Query: 533 IQNVSQIEGLSEDDIELKALTFENISTMGRAVKSAAFAEYAEPLV------NAAYEAIKT 586
++N Q E L+ T E IS +G AV F + A ++ + ++
Sbjct: 542 VENAVQKELRL-----LRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMED 596
Query: 587 DSARLRESGYAFIANMAKVYGKDFAPFLQTIIPEIFKT--LEQEEYQFNXXXXXXXXXXX 644
D ++ A+ A M K+ GK+F +L ++ + KT ++ E +
Sbjct: 597 DDPQISYMISAW-ARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDD 655
Query: 645 X-XXXXXXXQSKFTVNTGIAYXXXXXXXXXXXXXXXXXXHFLEYVEPSLKVLAEQVNESY 703
Q F + T F+EY E +K++ + +
Sbjct: 656 GWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYF 715
Query: 704 --GLKETALHSMWAIVKAVLLTANLKEGEYPKGVPSGSYVDASALAVIQTVREVSLNNVI 761
G++ A SM +L A ++ EY + + + +I
Sbjct: 716 HDGVRVAAAESM----PLLLECARVRGPEY-----------------LTQMWHFMCDALI 754
Query: 762 EEVETSMVISVFQDLSEMLRLFGPII-IMDNG--DSTHLDQLCREALSVL----KGEHAC 814
+ + T V LSE++ F I +M +G ++ H ++L + L K +
Sbjct: 755 KAIGTEPDSDV---LSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELR 811
Query: 815 QTIHFEEDVPEDED---LDASETEATLLDVALDIYVALSTNLVGGFAQVFTTAKPVILQL 871
Q +ED E + D + + +L DI ++ ++ F P+I+ L
Sbjct: 812 QVKRQDEDYDEQVEGTLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNL 871
Query: 872 -CQSKSKNKRSFAVGALSEIALGMRDENPFIQELLEALIISLTNDKSLEVRCNASYGVGL 930
C + R + + ++ + E ++ D S EVR A+YG+G+
Sbjct: 872 ICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGV 931
Query: 931 LIEYSSFDVSAIYSPVLKSLYEILSVADEKNLATEDDEATKEIVDRTFSNVCGCVARMIL 990
+ +Y + + L L ++ AD K TKE V+ T N V +++
Sbjct: 932 MAQYGGDNYRPFCTEALPLLVRVIQSADSK---------TKENVNAT-ENCISAVGKIMK 981
Query: 991 KHQNLVPLEHTIPALLSHLPFNTAFEEYDPIFKLFLKLFQEQNSTII----NEAPKVIAI 1046
+ V +E +P LS LP + EE F L + + ++ PK+ +I
Sbjct: 982 FKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSI 1041
Query: 1047 FA 1048
A
Sbjct: 1042 IA 1043
>YMR308c [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1089
Score = 135 bits (341), Expect = 3e-31
Identities = 140/640 (21%), Positives = 272/640 (41%), Gaps = 44/640 (6%)
Query: 9 LEQALGAIVQPTGSLKD-ATKTLQSQFYTQSAALPALIHILQN---SSNDGIKQLAGVEA 64
L Q + A P ++ A K L ++ T++ L + + S + + L+ V
Sbjct: 12 LLQIVQAFASPDNQIRSVAEKALSEEWITENNIEYLLTFLAEQAAFSQDTTVAALSAVLF 71
Query: 65 RKQ------------VSKHWGSLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGS 112
RK +SK+ + ++ SLL +E D++RH + IA
Sbjct: 72 RKLALKAPPSSKLMIMSKNITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQ 131
Query: 113 EELDEKKWPELIPNLLQAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTI 172
++L WPEL+ L+++ NP RE++ I+ ++ A + I+ L +F
Sbjct: 132 DDLPA--WPELLQALIESLKSGNPNFRESSFRILTTVPYLITA---VDINSILPIFQSGF 186
Query: 173 NDSASLETRSLSAQALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNT 232
D++ + + Y L + E +K L+PS++ L + +G
Sbjct: 187 TDASDNVKIAAVTAFVGYFKQLPKSEW-------SKLGILLPSLLNSLPRFLDDGKDDAL 239
Query: 233 KLIFNCLNDFLLLDSQLTGNTIADLVKLALQIAVNSDVDEDIRVFAVQFVT----SALVY 288
+F L + + L +L + +++ + N D++ R A++ +T +A
Sbjct: 240 ASVFESLIELVELAPKLFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQM 299
Query: 289 RKSKINQAKLGPEITLAALKVASEEIDVEDELTNEDEAGENEENTPALTALRLISNASGE 348
KS N + +TL + S + D E D+ + EE T A + + + +
Sbjct: 300 CKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYD-HARQALDRVALK 358
Query: 349 LSPSQVGVPIIEHLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVTGLK 408
L + P+ ++L M++S+ ER + ++A+S G D + + KI+ + +
Sbjct: 359 LGGEYLAAPLFQYLQQMITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLIN 418
Query: 409 DSEAVVQLAALKCIVQLSTNLQDEVAR-YHEQYLPLVIDIIDSAKHVVIYKYATLALDGL 467
D VQ + Q+ST+ + R H++ LP +I + S + +A AL
Sbjct: 419 DPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNF 478
Query: 468 LEFIAHNDIIKYLDPLMNKLFQMLETQQSPKLRAAIVSAIGSCAFAAGSGFVPYFKTSVQ 527
EF + + + YLD L+ L +L++ + ++ ++ I A AA + F+ Y+ T
Sbjct: 479 SEFASKDILEPYLDSLLTNLLVLLQSNKL-YVQEQALTTIAFIAEAAKNKFIKYYDT--- 534
Query: 528 YLQQFIQNVSQIEGLSEDDIELKALTFENISTMGRAVKSAAFAEYAEPLVNAAYEAIKTD 587
L + NV ++ ++D+ LK E + +G AV F E+++ L++ +D
Sbjct: 535 -LMPLLLNVLKVN--NKDNSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSD 591
Query: 588 ---SARLRESGYAFIANMAKVYGKDFAPFLQTIIPEIFKT 624
LR + + ++ G DF P L +IP + T
Sbjct: 592 IDEDDALRSYLEQSWSRICRILGDDFVPLLPIVIPPLLIT 631
>SPCC1840.03 [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1095
Score = 108 bits (269), Expect = 6e-23
Identities = 140/624 (22%), Positives = 259/624 (41%), Gaps = 48/624 (7%)
Query: 25 DATKTLQSQFYTQSA--ALPALIHILQNSSNDGIKQLAGVEARK---------QVSKHWG 73
DA K+L S + +Q A L L + S + ++ V R+ + +
Sbjct: 30 DAEKSLSSDWISQRADLLLNGLAILAYQSEDPAVRSFCLVLCRRISFRTLPGDSELEVFS 89
Query: 74 SLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELD-EKKWPELIPNLLQAAC 132
S+ ++ S++ LL E VR+ IA I D + +WPELI + A
Sbjct: 90 SISNESKQSLQSQLLACFVKESVPTVRNKLCDTIAEIARSIYDCQGEWPELINVIFNAVN 149
Query: 133 DSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLETRSLSAQALSYVS 192
+ RE+ I SL + D + T S+ R +A+A S V
Sbjct: 150 SPDESFRESVFRTITSLPRLLSGQ-----DSAVTPLFTTGLADPSIRVRISAARAYSAV- 203
Query: 193 SLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCLNDFLLLDSQLTGN 252
++E + Q L+PS++ +L ++ D+ N + + + +L
Sbjct: 204 -ILESKQSTRDQVIP----LLPSLMNILPPLQQDRDSDNLADCLMAITEIAEVFPKLFKP 258
Query: 253 TIADLVKLALQIAVNSDVDEDIRVFAVQFVT-----SALVYRKSKINQAKLGPEITLAAL 307
++ L I + ++D R A++ + + + RKS +L + L
Sbjct: 259 IFESVIAFGLGIIKDKELDNSARQAALELLVCFSEGAPAMCRKSSDYTDQLVLQCLLLMT 318
Query: 308 KVASEEIDVEDELT---NEDEAGENEENTPALTALRLISNASGELSPSQVGVPIIEHLPT 364
VA + D +EL N D+ ++E + + A + + S +L + P LP
Sbjct: 319 DVAGDPEDEAEELQEWLNTDDLDQDESDANHVVAEQAMDRLSRKLGGKTILPPSFTWLPR 378
Query: 365 MLSSSNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVTGLKDSEAVVQLAALKCIVQ 424
++ S ER + L+AIS + G+ + +++ + L D V+ AA + Q
Sbjct: 379 LIPSQKWSERHAALMAISSIAEGAEKLMKKELSRVLDMVLPLLADPHPRVRWAACNAVGQ 438
Query: 425 LSTNLQDEV-ARYHEQYLPLVIDIIDSAKHVVIYKYATLALDGLLEFIAHNDIIKYLDPL 483
+ST+ ++ +Y + L ++ +++S + V +A A+ E + + YLD +
Sbjct: 439 MSTDFAPDMQVKYPSRILEALVPVLESPESRV-QAHAAAAMVNFSEEADNKVLEPYLDDI 497
Query: 484 MNKLFQMLETQQSPK--LRAAIVSAIGSCAFAAGSGFVPYFKTSVQYLQQFIQNVSQIEG 541
+ +L +L QSPK ++ V+ I + A AA F YF + L +Q Q +G
Sbjct: 498 LQRLLTLL---QSPKRYVQEQAVTTIATVADAAAKKFEKYFDAIMPLLFNVLQ---QADG 551
Query: 542 LSEDDIELKALTFENISTMGRAVKSAAFAEYAEPLVNAA--YEAIKTDSARLRESGYAFI 599
++ L+ T E + + AV F ++ L+ + TDS + S Y
Sbjct: 552 --KEFRTLRGKTMECATLIALAVGKQRFLPVSQELIQILGNIQMGITDSDDPQAS-YLIS 608
Query: 600 A--NMAKVYGKDFAPFLQTIIPEI 621
A + +V G DF PFL +++P +
Sbjct: 609 AWGRICRVLGSDFVPFLSSVMPPL 632
>CE26971 [YU] KOG2171 Karyopherin (importin) beta 3
Length = 1092
Score = 106 bits (265), Expect = 2e-22
Identities = 213/1013 (21%), Positives = 401/1013 (39%), Gaps = 113/1013 (11%)
Query: 72 WGSLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELDEK---KWPELIPNLL 128
W +L+ + + +L +E + +++ A +I+ I S +D+ W ++ L+
Sbjct: 73 WETLNEENKQRILAKVLEMIVHETELSIKKKIADLISEIASNLIDDSGDMTWGGVL-ELM 131
Query: 129 QAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLETRSLSAQAL 188
S +IL N H L + + + L+ ++ + +A+
Sbjct: 132 DHCLKSEDLTGNYIALLILRGCPIIFGNRLAHFLPTLKVVLEKCMATPDLQIKATAVRAV 191
Query: 189 SYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCLNDFLLLDSQ 248
+ +EE ++ SL+P+V+QV + T E D+ L +F L S
Sbjct: 192 IAFAVDNDEEKDV----VRLMTSLVPNVLQVCNETSDEDDSDGP------LGEFAELASS 241
Query: 249 LTG--NT-IADLVKLALQIAVNSDVDEDIRVFAVQFVTSALVYRKSKINQ---AKLGPEI 302
L NT ++ ++++ L IA N + +E +R A++ + S + + + LGP +
Sbjct: 242 LPKCLNTHMSQVLQVTLAIAGNKEKNEMVRQNAIEVICSYMESAPKGLKKYAPGALGPIL 301
Query: 303 TLAALKVASEEIDVEDELTNEDEAGENEENTPAL--TALRLISNASGELSPSQVGVPIIE 360
+ + DV +E NE E E+ E+ P + +A+ ++ V +P++E
Sbjct: 302 ETLLSCMTEMDDDVLNEWLNEIEEEEDYEDIPIIAESAIDRVACCINGKVMLPVFLPLVE 361
Query: 361 HLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVTGLKDSEAVVQLAALK 420
L L+S + + + L A S + G ++I+ + D+ VQ AA
Sbjct: 362 KL---LTSEDWKMKHAALRAFSAVGEGCQRSMEPHIEQIMAHITNYVNDAHPRVQYAACN 418
Query: 421 CIVQLSTNLQDEVARY-HEQYLPLVIDIIDSAKHVVIYKYATLALDGLLEFIAHNDIIKY 479
I Q+S++ + + H +P +++ +D + +A AL E + I +Y
Sbjct: 419 AIGQMSSDFAPTLQKKCHAAVIPALLESLDRTDVPRVCAHAASALVNFAEECPKSIIGQY 478
Query: 480 LDPLMNKL-------FQMLETQQSPKLRAAIVSAIGSCAFAAGSGFVPYFKTSVQYLQQF 532
L ++ KL F L ++ + IV+AI S A AA F + + L
Sbjct: 479 LPFILQKLENVLSAVFNRLGDKRYQVVVENIVTAIASVAEAAEELFKEHHARLIPNLVHI 538
Query: 533 IQNVSQIEGLSEDDIELKALTFENISTMGRAVKSAAFAEYAEPLVNAAYEAIKTDSARLR 592
+QNV +++ EL+ T E IS +G AV F A ++N + +K +
Sbjct: 539 LQNVGELK-------ELRGKTIECISLIGYAVGKEQFHATAIEILNLLGDGMK--DLAID 589
Query: 593 ESGYAFIAN----MAKVYGKDFAPFLQTIIPEIFKTLE-QEEYQFNXXXXXXXXXXXXXX 647
+ Y+++ + + G DFAPFL ++ + + + ++
Sbjct: 590 DPQYSYMISSWTRFCSILGADFAPFLPVVMDPVLRAARYRPDFNIFNNEDVHENEEGVEY 649
Query: 648 XXXXXQSKFTVNTGIAYXXXXXXXXXXXXXXXXXXHFLEYVEPSLKVLAEQVNESYGLKE 707
+ + T F+ YV ++ + N +GL +
Sbjct: 650 HGIGGEKTVGIRTSGLEEKATACDMLVAFAKEMKEAFMPYVVDVYELAIK--NLDFGLHD 707
Query: 708 TALHSMWAIVKAVLLTANLKEG---------EYPKGVPSGSYVD------ASALAVIQTV 752
+ + A + LLT K+G E+ K + + + AS + I +
Sbjct: 708 -GVRTASAEIMPCLLTCVEKQGLADKRRLWCEFLKALTTSMEEEDDVEILASFMTTIGSC 766
Query: 753 REVSLNNVIEEVETSMVISVFQDLSEMLRLFGPIIIMDNGDSTHLDQLCREALSVLKGEH 812
EV I E E ++ISV L + L +G R + ++ E
Sbjct: 767 IEVMKTEGIAEEEVQLIISV---LLKQLENYGK----------------RMSDRPVEDED 807
Query: 813 ACQTIHFEEDVPEDEDLD-ASETEATLLDVALDIYVALSTNLVG----GFAQVFTTAKPV 867
++D E+LD E EA+ L D+ +L G G VF A
Sbjct: 808 -------DDDAEAKEELDYFMELEASCLGAISDLTHSLMKEFKGTIFEGMINVFNCA--- 857
Query: 868 ILQLCQ-SKSKNKRSFAVGALSE-IALGMRDENPFIQELLEALIISLTNDKSLEVRCNAS 925
+QL + SK +R + + L + I G+ +L+ ++ L D+ EVR AS
Sbjct: 858 -IQLIEGSKQYFERQWGMCLLDDAIEFGVGHMPTRFPKLI-PIMYKLLGDEYPEVRQAAS 915
Query: 926 YGVGLL-IEYSSFDVSAIYSPVLKSLYEILSVADEKNL-ATEDDEATKEIVDRTFSNVCG 983
YG G++ I Y +S + +L L + ++ ++ ATE+ E F+ + G
Sbjct: 916 YGFGVMAINY--HQISDYRNEILSCLEPLAAMIQREDARATEESTVATENAISAFAKIIG 973
Query: 984 CVARMILKHQNLVPLEHTIPALLSHLPFNTAFEEYDPIFKLFLKLFQEQNSTI 1036
V + +V + LS LP + EE I+ +LF +Q++ +
Sbjct: 974 NVPLPAEAYGKVVEM------FLSWLPTYSDTEESPYIYTCLAELFDKQDAAL 1020
>YLR347c [YU] KOG1241 Karyopherin (importin) beta 1
Length = 861
Score = 63.5 bits (153), Expect = 2e-09
Identities = 126/644 (19%), Positives = 267/644 (40%), Gaps = 67/644 (10%)
Query: 28 KTLQSQFYTQSAALPALIHILQNSSNDGIKQLAGVEAR-----------KQVSKHW-GSL 75
K L + + Q A L + + I +N+ +G + LA + + +Q ++ W +
Sbjct: 30 KKLSNDNFLQFAGLSSQVLIDENTKLEG-RILAALTLKNELVSKDSVKTQQFAQRWITQV 88
Query: 76 DAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGSEELDEKKWPELIPNLLQAACDSN 135
+ +K + L +A + + +A A++IA+I EL WPEL+ ++
Sbjct: 89 SPEAKNQIKTNAL-TALVSIEPRIANAAAQLIAAIADIELPHGAWPELMKIMVDNTGAEQ 147
Query: 136 PK-IRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLETR--------SLSAQ 186
P+ ++ ++ + + ES + + N+ + + S ET + A
Sbjct: 148 PENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLAALNALAD 207
Query: 187 ALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCLNDFLLLD 246
+L ++ + +E EGE N ++QV+ + D F CL + L
Sbjct: 208 SLIFIKNNMEREGERN------------YLMQVVCEATQAEDIEVQAAAFGCLCKIMSLY 255
Query: 247 SQLTGNTIADLVKLALQIAVNSDVDEDIRVFAVQFVTSA------LVYRKSKINQAKLGP 300
+ AL IA ++ + V+F ++ + Y ++ Q+ L
Sbjct: 256 YTFM-KPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPL-Q 313
Query: 301 EITLAALKVASEEIDVEDELTNEDEAGENEENTPALTA---LRLISNASGELSPSQVGVP 357
A + ++ + LT ++E E+++ +++A L+L + G + + P
Sbjct: 314 SYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCG----NHILEP 369
Query: 358 IIEHLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQF--DKIIPATVTGLKDSEAVVQ 415
++E + +++ N R + ++A ++ G PD + + +P+ + + D V+
Sbjct: 370 VLEFVEQNITADNWRNREAAVMAFGSIMDG-PDKVQRTYYVHQALPSILNLMNDQSLQVK 428
Query: 416 LAALKCIVQLSTNLQDEVARYHEQYLPLVID--IIDSAKHVVIYKYATLALDGLLEFIAH 473
CI +++ ++ + + +Q+LP V+ +I H + + + L+E +A
Sbjct: 429 ETTAWCIGRIADSVAESIDP--QQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAE 486
Query: 474 ---NDIIKYLDPLMNKLFQMLETQQSP-KLRAAIVSAIGSCA-FAAGSGFVPYFKTSVQY 528
+ I + L++ L + RA+ SA+ + +A + S
Sbjct: 487 ATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFV 546
Query: 529 LQQFIQNVSQIEG-LSEDDIELKALTFENISTMGRAV--KSAAFAE-YAEPLVNAAYEAI 584
+ + Q +S E L+ +D + NI T+ AV KS + E A+ L+ + +
Sbjct: 547 MDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLL 606
Query: 585 -KTDSARLRESGYAFIANMAKVYGKDFAPFLQTIIPEIFKTLEQ 627
K DSA + + + I+ +A GK F +L+T P + K L Q
Sbjct: 607 EKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQ 650
>YGL195w [J] KOG1242 Protein containing adaptin N-terminal region
Length = 2672
Score = 62.0 bits (149), Expect = 5e-09
Identities = 142/669 (21%), Positives = 262/669 (38%), Gaps = 80/669 (11%)
Query: 3 QQFVAQLEQALGAIVQPTGSLKDATKTL-QSQF--YTQSAALPALIHILQNSSNDGIKQL 59
Q+ V L QA+G PT ++A +L Q+QF Y +L +IHI+ +D +
Sbjct: 1525 QKLVPVLLQAIG---DPTKYTEEALDSLIQTQFVHYIDGPSLALIIHIIHRGMHDRSANI 1581
Query: 60 AGVEARKQVSKHWGSLDAATQTSVKQSLLNSAFNEGKDAVRHANARVIASIGS--EELDE 117
+A K V +D Q L++ D V + A ++G+ E L E
Sbjct: 1582 KR-KACKIVGNMAILVDTKDLIPYLQQLIDEVEIAMVDPVPNTRATAARALGALVERLGE 1640
Query: 118 KKWPELIPNLLQAACDSNPK---------IRETAIFIILSLLESFNANLALHIDDFLNLF 168
+++P+LIP LL D + + E + L+ L+ + + +F
Sbjct: 1641 EQFPDLIPRLLDTLSDESKSGDRLGSAQALAEVISGLGLTKLDEMLPTILAGVTNFRAYI 1700
Query: 169 AQTINDSASLETRSLSAQALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGD 228
+ +Q Y++ +I+ I A ++ + ++ ++
Sbjct: 1701 REGFMPLLLFLPVCFGSQFAPYINQIIQP---ILSGLADNDENIRDTALKAGKLIVKNYA 1757
Query: 229 TTNTKLIFNCL-------NDFLLLDS-QLTGNTIADLVKLALQIAVNSDVDEDIRVFAVQ 280
T L+ L ND + L S QLTG + + ++ + + + + F+ +
Sbjct: 1758 TKAVDLLLPELERGMFDENDRIRLSSVQLTGELLFQVTGISSRNEFSEEDGDHNGEFSGK 1817
Query: 281 FVTSALVYRKSKINQAKLGPEITLAALKVASEEIDVEDELTNEDEAGENEENTPALTALR 340
V R+ +I A + + V + +D+ L +E P LT +
Sbjct: 1818 LVDVLGQDRRDRILAALFVCRNDTSGI-VRATTVDIWKALVPNTPRAV-KEILPTLTGMI 1875
Query: 341 LISNAS-------------GELSPSQVGVPIIEHLPTM----LSSSNPFERRSILLAISV 383
+ AS G+L G + + LP++ + +SN R+ + +A+
Sbjct: 1876 VTHLASSSNVLRNIAAQTLGDLVRRVGGNALSQLLPSLEESLIETSNSDSRQGVCIALYE 1935
Query: 384 LVTGSPDYTLSQFDKIIPATV-TGLKDSEAVVQLAALKCIVQLSTNL-QDEVARYH-EQY 440
L+ + T+SQF I + T L D A V+ AA LS ++ QD V + ++
Sbjct: 1936 LIESASTETISQFQSTIVNIIRTALIDESATVREAA-----ALSFDVFQDVVGKTAVDEV 1990
Query: 441 LPLVIDIIDSAKHVVIYKYATLALDGLLEFIAHNDIIKYLDPLMNKLFQMLETQQSPKLR 500
LP ++ +++S+ + + AL GL E ++ + + P+ ++ T +P +
Sbjct: 1991 LPYLLHMLESSDN------SDFALLGLQEIMSKKSDVIF--PI------LIPTLLAPPID 2036
Query: 501 AAIVSAIGSCAFAAGSGFVPYFKTSVQYLQQFIQNVSQIEGLSEDDIELKALTFENISTM 560
A SA+GS A AGS + L V I G SED+ AL +
Sbjct: 2037 AFRASALGSLAEVAGSALYKRLSIIINAL------VDAIIGTSEDESTKGALEL----AL 2086
Query: 561 GRAVKSAAFAEYAEPLVNAAYEAIKTDSARLRESGYAFIANMAKVYGKDFAPFLQTIIPE 620
R S E PL+ +K+D+ R + + N DF ++ +
Sbjct: 2087 DRVFLSVNDDEGLHPLLQQIMSLLKSDNIEKRIAVLERLPNFFDKTVLDFDVYIPNFVSH 2146
Query: 621 IFKTLEQEE 629
+L+ E+
Sbjct: 2147 AILSLDDED 2155
>SPAC2F3.06c [YU] KOG2023 Nuclear transport receptor
Karyopherin-beta2/Transportin (importin beta
superfamily)
Length = 910
Score = 54.7 bits (130), Expect = 8e-07
Identities = 99/475 (20%), Positives = 194/475 (40%), Gaps = 51/475 (10%)
Query: 123 LIPNLLQAACDSNPKIRETAIFIILSLLESFNANLALHIDDFLNLFAQTINDSASLETRS 182
+IP ++ A NPKIR A+F + + + +L HID FL D S R
Sbjct: 179 MIPRFIELARHENPKIRTDALFCLNQFVLIQSQSLYAHIDTFLETCYALATD-VSPNVRK 237
Query: 183 LSAQALSYVSSLIEEEGEINPQYAAKFASLIPSVVQVLDATIREGDTTNTKLIFNCLNDF 242
QAL Y+ ++ P + PS+ +++ + ++ + +
Sbjct: 238 NVCQALVYLL-------DVRPD------KIAPSLGSIVEYMLYSTQDSDQNVALEACEFW 284
Query: 243 LLLDSQ-----LTGNTIADLVKLALQIAVNSDVD-----EDIRVFAV----QFVTSALVY 288
L + Q G + +V + LQ V SD+D D + V + +
Sbjct: 285 LAIAEQPDLCSALGPYLDKIVPMLLQGMVYSDMDLLLLGNDADDYDVEDREEDIRPQHAK 344
Query: 289 RKSKINQAKLGPEITLAALKVASEEIDVEDELTNEDEAGENEENTPALTALRLISNASGE 348
KS+I GP + ++E++ EDE ++DE E+++ + + A
Sbjct: 345 GKSRITLNTQGPITQQGSSNADADELEDEDE--DDDEFDEDDDAFMDWNLRKCSAAALDV 402
Query: 349 LS---PSQVGVPIIEHLPTMLSSSNPFERRSILLAISVLVTGSPDYTLSQFDKIIPATVT 405
LS ++ I+ HL L+S + + + +LA+ + G D + ++ P ++
Sbjct: 403 LSSFWKQRLLEIILPHLKQSLTSEDWKVQEAGVLAVGAIAEGCMDGMVQYLPELYPYFLS 462
Query: 406 GLKDSEAVVQLAALKCIVQLS---TNLQDEVARYHEQYLPLVID----IIDSAKHVVIYK 458
L + +V+ + + S + L+ E R + ++PL+ ++D+ K V +
Sbjct: 463 LLDSKKPLVRTITCWTLGRYSKWASCLESEEDR-QKYFVPLLQGLLRMVVDNNKKV---Q 518
Query: 459 YATLALDGLLEFIAHNDIIKYLDPLMNKLFQMLETQQSPKLRAAIVSAIGSCAFAAGSGF 518
A + +LE A ++ YL+P++ L + Q + + A+ + A GS
Sbjct: 519 EAGCSAFAILEEQAGPSLVPYLEPILTNLAFAFQKYQRKNV-LILYDAVQTLADYVGSAL 577
Query: 519 VPYFKTSVQYLQQFIQNVSQIEGLSEDDIELKALTFENISTMGRAVKSAAFAEYA 573
+Y++ I + Q + DD FE +S++ A++ FA +A
Sbjct: 578 -----NDKRYIELLITPLLQKWSMIPDDDPNLFPLFECLSSVAVALRD-GFAPFA 626
>Hs16161756 [YU] KOG2171 Karyopherin (importin) beta 3
Length = 414
Score = 54.3 bits (129), Expect = 1e-06
Identities = 73/327 (22%), Positives = 132/327 (40%), Gaps = 40/327 (12%)
Query: 776 LSEMLRLFGPII-IMDNG--DSTHLDQLCREALSVLKGEHACQTIHFEEDVPEDEDL--- 829
LSE++ F I +M +G + HL++L + L+G Q + + E+ D
Sbjct: 83 LSEIMNSFAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVE 142
Query: 830 ----DASETEATLLDVALDIYVALSTNLVGGFAQVFTTAKPVILQL-CQSKSKNKRSFAV 884
D E + +L DI +L + F P+I+ L C S+ R + +
Sbjct: 143 MSLQDEDECDVYILTKVSDILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGL 202
Query: 885 GALSEIALGMRDENPFIQELLEALIISLTNDKSLEVRCNASYGVGLLIEYSSFDVSAIYS 944
+I + E ++ D + EVR A+YG+G++ ++ D ++ S
Sbjct: 203 CIFDDIIEHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCS 262
Query: 945 PVLKSLYEILSVADEKNLATEDDEATKEIVDRTFSNVCGCVARMILKHQNLVPLEHTIPA 1004
+ L +++ A+ K TK+ V T N + +++ N V ++ +P
Sbjct: 263 EAVPLLVKVIKCANSK---------TKKNVIAT-ENCISAIGKILKFKPNCVNVDEVLPH 312
Query: 1005 LLSHLPFNTAFEEYDPIFKLFLKLFQEQNSTII----NEAPKVIAIFATVFEKESERIEL 1060
LS LP + EE L + + +I + PK+I+I A E
Sbjct: 313 WLSWLPLHEDKEEAIQTLSFLCDLIESNHPVVIGPNNSNLPKIISIIA----------EG 362
Query: 1061 ETNSTLGREENLEKR-----KQFQSEE 1082
+ N T+ E+ KR +Q Q+ E
Sbjct: 363 KINETINYEDPCAKRLANVVRQVQTSE 389
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.132 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,584,247
Number of Sequences: 60738
Number of extensions: 2295307
Number of successful extensions: 8735
Number of sequences better than 1.0e-05: 15
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 8633
Number of HSP's gapped (non-prelim): 65
length of query: 1113
length of database: 30,389,216
effective HSP length: 117
effective length of query: 996
effective length of database: 23,282,870
effective search space: 23189738520
effective search space used: 23189738520
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)