ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV5585 good U KOG1087 Intracellular trafficking, secretion, and vesicular transport Cytosolic sorting protein GGA2/TOM1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV5585 1919127 1917385 -581
(581 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YHR108w [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 511 e-144
YDR358w [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 446 e-125
SPBC25H2.16c [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 281 3e-75
SPAC1F3.05 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 238 1e-62
Hs20336267 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 95 3e-19
Hs9558729 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylation... 87 7e-17
7294938 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 85 3e-16
Hs4885637 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 82 2e-15
Hs9558751 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylation... 81 5e-15
CE25764 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 79 1e-14
At3g08790 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 78 4e-14
CE27055 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 77 6e-14
Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 74 5e-13
At2g38410 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 70 7e-12
At1g21380 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 69 3e-11
Hs4885639 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 67 7e-11
7297777 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 66 2e-10
Hs4758528 [TU] KOG1818 Membrane trafficking and cell signaling p... 65 3e-10
At5g16880 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 64 6e-10
Hs14719400 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylatio... 63 1e-09
CE03788 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylation f... 62 3e-09
7291071 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylation f... 61 5e-09
At5g01760 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 60 9e-09
Hs21265031 [T] KOG2199 Signal transducing adaptor protein STAM/S... 58 5e-08
CE06781 [TU] KOG1818 Membrane trafficking and cell signaling pro... 56 2e-07
HsM19923337 [T] KOG2199 Signal transducing adaptor protein STAM/... 53 1e-06
At1g60070 [U] KOG1062 Vesicle coat complex AP-1 gamma subunit 53 1e-06
CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 52 2e-06
At1g23900 [U] KOG1062 Vesicle coat complex AP-1 gamma subunit 52 2e-06
SPAC19A8.05c [TU] KOG1818 Membrane trafficking and cell signalin... 50 7e-06
>YHR108w [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 585
Score = 511 bits (1316), Expect = e-144
Identities = 257/350 (73%), Positives = 296/350 (84%), Gaps = 1/350 (0%)
Query: 3 SIHLDEGPVRRMQPQSDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAIS 62
SI+L E PVR+ Q +PL RKIQRACR+SL EPDLALNLD+ADYIN+KQGAAPR+AAI+
Sbjct: 8 SIYLSELPVRKPQALGNPLLRKIQRACRMSLAEPDLALNLDIADYINEKQGAAPRDAAIA 67
Query: 63 IVRLINSRDTHTAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQ 122
+ +LIN+R++H AIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFP PP+R+SK+Q
Sbjct: 68 LAKLINNRESHVAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPGHPPLRYSKIQ 127
Query: 123 RLILTAIEEWYQTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKT 182
RLILTAIEEWYQTICKHS+YK DMGYIRDMHRLLKYKGY FPKI+ DLAVLKPS LKT
Sbjct: 128 RLILTAIEEWYQTICKHSSYKNDMGYIRDMHRLLKYKGYAFPKISESDLAVLKPSNQLKT 187
Query: 183 PSEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTKL 242
SEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMK+MAGFKEDN +Q+KQ ++ EL KL
Sbjct: 188 ASEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMKIMAGFKEDNAVQAKQAISSELNKL 247
Query: 243 RRKADLLNEMLGTNDSPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFND 302
+RKADLLNEML + DS + +NET EL++AL+ +QP+FQKIIEEE +DD VQDLLKFND
Sbjct: 248 KRKADLLNEMLESPDSQNWDNETTQELHSALKVAQPKFQKIIEEEQEDDALVQDLLKFND 307
Query: 303 TVNQLVQKYDLLKAGHAGEAXXXX-XXXXXXXXXXGGALANEINLIDFDD 351
TVNQL++K++LLK G + A GAL NEINLIDF+D
Sbjct: 308 TVNQLLEKFNLLKNGDSNAASQIHPSHVSAPLQQSSGALTNEINLIDFND 357
Score = 123 bits (308), Expect = 9e-28
Identities = 68/136 (50%), Positives = 89/136 (65%), Gaps = 5/136 (3%)
Query: 446 DLLSEFSAPAVQHSTQPSIVSDRFLVNQSDVLKFEFAISRESESTIKVTSFFSNVSISQL 505
DLL F+ P +T P+ R LVNQS LK EF ISRES S I++ SFF+N+S S +
Sbjct: 455 DLLMGFN-PTTGTTTAPA----RTLVNQSPNLKIEFEISRESNSVIRIKSFFTNLSSSPI 509
Query: 506 TDLTLMLAVPKAQQLRLLPQSNTVLSSYAKDGIHQKSWIDNAVKNAPKPLRVKWKVSYKA 565
++L +LAVPK+ L+L PQS+ + AKDGI Q+ I+NA N K L+VKWKV+Y
Sbjct: 510 SNLVFLLAVPKSMSLKLQPQSSNFMIGNAKDGISQEGTIENAPANPSKALKVKWKVNYSV 569
Query: 566 NGVPKEESAVYTFPNV 581
N EE+AV+T PNV
Sbjct: 570 NSTQAEETAVFTLPNV 585
>YDR358w [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 557
Score = 446 bits (1148), Expect = e-125
Identities = 221/349 (63%), Positives = 271/349 (77%), Gaps = 10/349 (2%)
Query: 4 IHLDEGPVRRMQPQSDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISI 63
I L PVR+ + L RKIQRACR +LPEPDL LNLDVADYIN KQGA PREA ++I
Sbjct: 5 IELTSEPVRKPRSTESSLLRKIQRACRSTLPEPDLGLNLDVADYINSKQGATPREAVLAI 64
Query: 64 VRLINSRDTHTAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQR 123
+L+N+ DT A+FALSLLDVLVKNCGY HLQISRKEFLN+LVKRFPE+PP+R+SKVQ+
Sbjct: 65 EKLVNNGDTQAAVFALSLLDVLVKNCGYSIHLQISRKEFLNDLVKRFPEQPPLRYSKVQQ 124
Query: 124 LILTAIEEWYQTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTP 183
+IL AIEEWYQTICKH++YK+D+ YI DMH+LLKYKGYTFPK+ SE+LAVL+P++ L+TP
Sbjct: 125 MILEAIEEWYQTICKHASYKDDLQYINDMHKLLKYKGYTFPKVGSENLAVLRPNDQLRTP 184
Query: 184 SEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTKLR 243
SE+Q+EQE AQAAKLEEL+R GKP+DL+EANKLMK+MAGFK+D + KQ +N EL KL+
Sbjct: 185 SELQEEQERAQAAKLEELLRSGKPDDLKEANKLMKIMAGFKDDTKVAVKQAINNELNKLK 244
Query: 244 RKADLLNEMLGTNDSPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDT 303
RKADL NEML + D PD+ENE I ELY L+S+QP+F+K+IEEE DDD V +L KFND
Sbjct: 245 RKADLFNEMLTSADEPDLENEAIQELYGDLKSAQPKFKKLIEEERDDDALVSNLSKFNDL 304
Query: 304 VNQLVQKYDLLKAGHAGEAXXXXXXXXXXXXXXGGALANEINLIDFDDE 352
V QL+++Y +K E A E+NLIDFDD+
Sbjct: 305 VIQLLKRYKSIKGMKEEELNVPDT----------NEPAKELNLIDFDDD 343
Score = 93.2 bits (230), Expect = 1e-18
Identities = 44/124 (35%), Positives = 76/124 (60%)
Query: 458 HSTQPSIVSDRFLVNQSDVLKFEFAISRESESTIKVTSFFSNVSISQLTDLTLMLAVPKA 517
+S + + S R ++NQSD L+ ++ ++RES + +++ F+SN+S +T+ L++A PK
Sbjct: 434 NSKEITAQSQRHILNQSDHLRIDYELTRESMTKLRLVIFYSNISSDPITNFALLVASPKG 493
Query: 518 QQLRLLPQSNTVLSSYAKDGIHQKSWIDNAVKNAPKPLRVKWKVSYKANGVPKEESAVYT 577
L L PQS +L S ++DGI Q + ++ N KP+++KWK +Y G KEES +
Sbjct: 494 TTLSLQPQSGNMLQSNSRDGIKQIASVEGISVNLGKPIKLKWKANYCTKGDSKEESGTTS 553
Query: 578 FPNV 581
P +
Sbjct: 554 LPTI 557
>SPBC25H2.16c [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 533
Score = 281 bits (718), Expect = 3e-75
Identities = 151/300 (50%), Positives = 196/300 (65%), Gaps = 2/300 (0%)
Query: 25 IQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAIFALSLLDV 84
IQ A EPDLA+NLD+AD IN G PREAA +IVR +N R+ A AL+LLD+
Sbjct: 12 IQNATEPYAFEPDLAVNLDIADLINQTGGNLPREAAFAIVRKVNDRNPTVAYLALNLLDI 71
Query: 85 LVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTICKHSAYKE 144
VKNCGY F LQI+ KEFLNELV+RFPERPP R +K+Q +IL+ IEEW +TIC+ YKE
Sbjct: 72 CVKNCGYAFRLQIASKEFLNELVRRFPERPPSRLNKIQVMILSLIEEWRKTICRVDRYKE 131
Query: 145 DMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKEQEIAQAAKLEELIRR 204
D+G+IRDMHRLL YKGYTFP+I+ E+LAVL LKT E++KE A +AKL+ELIRR
Sbjct: 132 DLGFIRDMHRLLSYKGYTFPEIDKENLAVLSQKSVLKTAEELEKEDREAMSAKLQELIRR 191
Query: 205 GKPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTKLRRKADLLNEMLGTNDSPD--IE 262
G P DL EANKLMKVMAG+ + + K+ + +L K++RKA L EML D
Sbjct: 192 GTPADLAEANKLMKVMAGYDTEQKQKYKEHVLVDLEKVKRKAALFGEMLNEVSESDKLAS 251
Query: 263 NETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVNQLVQKYDLLKAGHAGEA 322
+ EL +L+++Q + KI+EE +D+ + + L+ +YD L G A
Sbjct: 252 GDLYDELAYSLKAAQRKVDKILEEMSPEDDSYVTVSDLKSLIASLLTQYDHLLEGDFSSA 311
Score = 51.2 bits (121), Expect = 4e-06
Identities = 38/140 (27%), Positives = 69/140 (49%), Gaps = 8/140 (5%)
Query: 436 VQAQQDTHSNDLLSEFSAPAVQHSTQPSIVSDRFLVN---QSDVLKFEFAISRESESTIK 492
V+A + + L F++P S P++ + F ++ L F+ ++ +
Sbjct: 388 VEAPAEVGAISLTESFNSPVSNSS--PNVPINNFTSTCAFENSHLNFQITPKSKTRDQVV 445
Query: 493 VTSFFSNVS-ISQLTDLTLMLAVPKAQQLRLLPQSNTVLSSYAKDGIHQKSWIDNAVKNA 551
+ + ++N+S + +L +AVPK L L PQS T LS KDGI+Q+ + +
Sbjct: 446 LLATYTNLSPYDTVENLQSFIAVPKKYNLVLQPQSGTNLSPLQKDGIYQEMIVTKLLDVT 505
Query: 552 PKPLRVKWKVSYKANGVPKE 571
P V++K++YK NG +E
Sbjct: 506 ELP--VRFKLTYKVNGRSQE 523
>SPAC1F3.05 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 510
Score = 238 bits (608), Expect = 1e-62
Identities = 120/303 (39%), Positives = 191/303 (62%), Gaps = 4/303 (1%)
Query: 18 SDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAIF 77
S L++ I +A EP+LALN+++AD IN+K+G PREAA+ I++ +NS + +
Sbjct: 4 SQTLSKYIDKATDQFNLEPNLALNIEIADLINEKKGNTPREAALLILKRVNSANPTVSYL 63
Query: 78 ALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTIC 137
AL LLD+ VKNCGYPFH QI+ +EFLN V RFP P R +K+Q +L +EEW +C
Sbjct: 64 ALHLLDICVKNCGYPFHFQIASEEFLNGFVSRFPNHPISRMNKIQSKMLEMLEEWNYMLC 123
Query: 138 KHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKEQEIAQAAK 197
K++ ++ED I D+ L+ ++GY FP ++ + +AV+KP+ L++ E+ +E A AK
Sbjct: 124 KNNRHREDFSRIHDIRELMAFRGYKFPAVDEDSIAVMKPNNSLRSAQELAREDLEAHKAK 183
Query: 198 LEELIRRGKPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTKLRRKADLLNEMLGTND 257
L+EL+RRG P DL EAN LMKV+AG+ E+N + +L +R KA + + L N
Sbjct: 184 LQELLRRGTPMDLAEANALMKVIAGYDEENTEDYSALAAADLESIRSKALRVKQFL-VNQ 242
Query: 258 SPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVNQLVQK---YDLL 314
+ +E T+ + +L+ Q + +I+ EE++D+ +VQ LL ND + ++++ DL+
Sbjct: 243 TVSLEEGTLADAVESLKVYQTKIARILREENEDEYYVQKLLSLNDLLINVIEECSNSDLI 302
Query: 315 KAG 317
+G
Sbjct: 303 HSG 305
>Hs20336267 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 723
Score = 95.1 bits (235), Expect = 3e-19
Identities = 83/311 (26%), Positives = 147/311 (46%), Gaps = 22/311 (7%)
Query: 15 QPQSDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHT 74
+ + + L + +A S + D + D IN K+ P+ A + I S
Sbjct: 3 EAEGESLESWLNKATNPSNRQEDWEYIIGFCDQIN-KELEGPQIAVRLLAHKIQSPQEWE 61
Query: 75 AIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRF-PERPPVRFS-KVQRLILTAIEEW 132
A+ AL++L+ +KNCG FH ++ + FLNEL+K P+ R S KV+ ++ + W
Sbjct: 62 ALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSW 121
Query: 133 YQTICKHSAYKEDMGYIRDMHRLLKYKG--YTFPKINSEDLAVLKPSEHLKTPSEIQKEQ 190
+ + + I+D + +LK +G + P I + + P K P +E
Sbjct: 122 TMALPEEAK-------IKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEE- 173
Query: 191 EIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDN-MIQSKQILNEELTKLRRKADLL 249
++ L +L++ P+DL+EANKL+K M KED IQ L ++ LL
Sbjct: 174 ---KSKLLAKLLKSKNPDDLQEANKLIKSMV--KEDEARIQKVTKRLHTLEEVNNNVRLL 228
Query: 250 NEML---GTNDSPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVNQ 306
+EML DS D + E + EL++ + + K+ E D+D + D+L+ +D +++
Sbjct: 229 SEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSR 288
Query: 307 LVQKYDLLKAG 317
++ Y + G
Sbjct: 289 VINSYKTIIEG 299
>Hs9558729 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylation factor
effector GGA
Length = 639
Score = 87.0 bits (214), Expect = 7e-17
Identities = 84/314 (26%), Positives = 144/314 (45%), Gaps = 24/314 (7%)
Query: 14 MQPQSDP--LTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRD 71
M+P +P L +I RA E D A + +N+ P + + I S
Sbjct: 1 MEPAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRL-LAHKIQSPQ 59
Query: 72 THTAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRF-PERPPVRFS-KVQRLILTAI 129
AI AL++L+ +K+CG FH ++ + FLNEL+K P+ R S KV+ IL +
Sbjct: 60 EWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELL 119
Query: 130 EEWYQTICKHSAYKEDMGYIRDMHRLLKYKGY--TFPKINSEDLAVLKPSEHLKTPSEIQ 187
W T+ K I + +++LK +G + PK+ + L P P +
Sbjct: 120 YSW--TVGLPEEVK-----IAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPR----PKNVI 168
Query: 188 KEQEIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTKLRRKAD 247
E E ++ L L++ PEDLR ANKL+K M + M + + +N + ++
Sbjct: 169 FEDE-EKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVN-AIEEVNNNVK 226
Query: 248 LLNEMLGTND----SPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDT 303
LL EM+ ++ + + + ELY +P ++ + D+DE + ++L+ ND
Sbjct: 227 LLTEMVMSHSQGGAAAGSSEDLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDN 286
Query: 304 VNQLVQKYDLLKAG 317
+ Q++ Y L G
Sbjct: 287 LTQVINLYKQLVRG 300
>7294938 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 543
Score = 85.1 bits (209), Expect = 3e-16
Identities = 77/306 (25%), Positives = 138/306 (44%), Gaps = 30/306 (9%)
Query: 18 SDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINS---RDTHT 74
S P+ ++I+ A +L + A N+++ D IN+ A R+A +I + ++ ++
Sbjct: 15 STPVGQRIEAATDANLASENWAANMEICDMINESSDTA-RDAMRAIRKRLSQNAGKNNQV 73
Query: 75 AIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRF-PERPPVRFSKVQRLILTAIEEWY 133
++ L++L+ VKNCG FH+ +++K+F+NELVK P+ P + +Q +L+ I+ W
Sbjct: 74 VMYTLTVLETCVKNCGKAFHVLVAQKDFINELVKLIGPKNDPP--AAMQEKVLSLIQIWA 131
Query: 134 QTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKEQEIA 193
+ D+ + M+ LK KG FP + DL + P + TP E
Sbjct: 132 DAF----KNQPDLNGVTQMYMELKNKGIEFP---ANDLDAMAP---IYTPQRSVPEMPPQ 181
Query: 194 QAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNMI----QSKQILNEELTKLRRKADLL 249
A + I P+ + A A + + L EL + +L
Sbjct: 182 LVAAQQHTI---SPQHMAAAAAAAAAAAAPPSTGPLHLTPEQAAKLRSELEIVSNNMSIL 238
Query: 250 NEMLGT----NDSPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVN 305
+EML +SPD + + EL + + Q R +I DDE + L+ ND +N
Sbjct: 239 SEMLSVLKPGQESPD-DYALLNELTSTCKEMQSRIVDLIGRV-QDDELTAEFLRINDELN 296
Query: 306 QLVQKY 311
+ ++
Sbjct: 297 NVFLRH 302
>Hs4885637 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 492
Score = 82.0 bits (201), Expect = 2e-15
Identities = 74/317 (23%), Positives = 149/317 (46%), Gaps = 27/317 (8%)
Query: 16 PQSDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIV-RLINSRDTHT 74
P S P+ ++I++A SL D ALN+++ D IN+ + P++A ++ R++ +++ H
Sbjct: 8 PFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETE-EGPKDALRAVKKRIVGNKNFHE 66
Query: 75 AIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKR--FPERPPVRFSKVQRLILTAIEEW 132
+ AL++L+ VKNCG+ FH+ ++ ++F+ ++ R P+ P V +L I+ W
Sbjct: 67 VMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTI--VHDKVLNLIQSW 124
Query: 133 YQTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKEQEI 192
D+ + ++ L+ KG FP + + L+ + + SE Q Q+
Sbjct: 125 ADAF----RSSPDLTGVVTIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDS 180
Query: 193 AQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNMI--QSKQI--LNEELT----KLRR 244
++ ED + + D I +QI L EL +R
Sbjct: 181 VGTDSSQQ-------EDSGQHAAPLPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRV 233
Query: 245 KADLLNEMLGTNDSPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTV 304
+++L E++ T P + E + EL R+ Q R ++I + +++ ++LL ND +
Sbjct: 234 MSEMLTELVPTQAEP-ADLELLQELNRTCRAMQQRVLELI-PQIANEQLTEELLIVNDNL 291
Query: 305 NQLVQKYDLLKAGHAGE 321
N + +++ + G+
Sbjct: 292 NNVFLRHERFERFRTGQ 308
>Hs9558751 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylation factor
effector GGA
Length = 613
Score = 80.9 bits (198), Expect = 5e-15
Identities = 76/308 (24%), Positives = 147/308 (47%), Gaps = 36/308 (11%)
Query: 25 IQRACRISLPEPDLALNLDVADYIN-DKQGAAPREAAISIVRLINSRDTHTAIFALSLLD 83
+ +A S+ E D + + + +N D G P A + I S A++AL++L+
Sbjct: 30 LNKATDPSMSEQDWSAIQNFCEQVNTDPNG--PTHAPWLLAHKIQSPQEKEALYALTVLE 87
Query: 84 VLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFS--KVQRLILTAIEEWYQTICKHSA 141
+ + +CG FH ++++ FLNEL+K + ++ KV+ ++ + W T+
Sbjct: 88 MCMNHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSW--TVW---- 141
Query: 142 YKEDMGYIRDMHRLLKYKGY--TFPKINSEDLAVLKPSEHLKTPSEIQKEQEIAQAAKLE 199
+ ED+ IRD +++LK +G PK+ + +L P S ++E ++ L
Sbjct: 142 FPEDI-KIRDAYQMLKKQGIIKQDPKLPVD--KILPPPSPWPKSSIFDADEE--KSKLLT 196
Query: 200 ELIRRGKPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTK-------LRRKADLLNEM 252
L++ PEDL+ AN+L+K N+++ +Q +E+++K +R +L EM
Sbjct: 197 RLLKSNHPEDLQAANRLIK--------NLVKEEQEKSEKVSKRVSAVEEVRSHVKVLQEM 248
Query: 253 LGTNDSP---DIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVNQLVQ 309
L P + E + +Y +P ++ + DDD+ + ++L+ ND + Q V
Sbjct: 249 LSMYRRPGQAPPDQEALQVVYERCEKLRPTLFRLASDTTDDDDALAEILQANDLLTQGVL 308
Query: 310 KYDLLKAG 317
Y + G
Sbjct: 309 LYKQVMEG 316
>CE25764 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 437
Score = 79.3 bits (194), Expect = 1e-14
Identities = 75/333 (22%), Positives = 156/333 (46%), Gaps = 51/333 (15%)
Query: 16 PQSDPLTRKIQRACRISL-PEPDLALNLDVADYINDKQGAAPREAAISIVRLIN---SRD 71
P + P+ RKI+ A +L + LN+++ D+IN + PR+A ++ + ++ S++
Sbjct: 34 PFATPVGRKIELATDANLLATENWGLNMEICDFINGTEDG-PRDAVRALKKRLHNAMSKN 92
Query: 72 THTAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFP---ERPPVRFSKVQRLILTA 128
++ L++L+ VKNC + FH+ + K+F+ +L+K + P + +Q +L+
Sbjct: 93 NAVVMYTLTVLETAVKNCNHHFHVLVCNKDFVQDLIKLIGPKFDAPQI----IQERVLSL 148
Query: 129 IEEWYQTICKHSAYKED--MGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSE----HLKT 182
I+ W A++ D + + + LK KG FP + + LA +K + +
Sbjct: 149 IQAW------ADAFRGDPTLAGVVQSYDDLKSKGVEFPAADLDTLAPIKTPKRTVFNQPP 202
Query: 183 PSEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNMIQSKQILN---EEL 239
P+ + +Q+ Q + + + P+ + + + Q ++ ++ +L
Sbjct: 203 PATLDDQQQQNQQQQQQPQQGQQNPQSTYDVLTIRE-----------QGQEPISATPAQL 251
Query: 240 TKLRRKADLLN-----------EMLGTNDSPDIENETIVELYNALRSSQPRFQKIIEEEH 288
TKLR D++N +++ ++ D E + + +L + R Q R +I
Sbjct: 252 TKLRADLDVVNQNIKVFRETLTDVVPRKETAD-ELQLLSDLNDTCRHMQQRVLDLIRYV- 309
Query: 289 DDDEFVQDLLKFNDTVNQLVQKYDLLKAGHAGE 321
+DE +LL ND++N + +KYD + GE
Sbjct: 310 SNDEVTYELLMVNDSLNSVFEKYDRFVSNRDGE 342
>At3g08790 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 607
Score = 77.8 bits (190), Expect = 4e-14
Identities = 64/295 (21%), Positives = 129/295 (43%), Gaps = 34/295 (11%)
Query: 25 IQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAIFALSLLDV 84
+ RA L PD A+NL++ D +N + G RE I + + SR + + AL+LL+
Sbjct: 6 VDRATSDMLIGPDWAMNLEICDMLNHEPGQT-REVVSGIKKRLTSRTSKVQLLALTLLET 64
Query: 85 LVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTICKHSAYKE 144
++ NCG H+Q++ K+ L+++VK +P + +V+ IL I+ W ++
Sbjct: 65 IITNCGELIHMQVAEKDILHKMVKMAKRKPNI---QVKEKILILIDTWQESFSGPQGRHP 121
Query: 145 DMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKEQEIAQAAKLEELIRR 204
Y LL+ G FP+ + + + P + ++ A E
Sbjct: 122 Q--YYAAYQELLR-AGIVFPQRPQITPSSGQNGPSTRYPQNSRNARQEAIDTSTESEFPT 178
Query: 205 GKPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTKLRRKADLLNEMLGTNDSPDIENE 264
+++ A +M V+ A+++N + G N+ ++ E
Sbjct: 179 LSLTEIQNARGIMDVL-------------------------AEMMNAIDG-NNKEGLKQE 212
Query: 265 TIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVNQLVQKYDLLKAGHA 319
+V+L + R+ + R ++ D+ Q L ND + +L+ K++ + +G++
Sbjct: 213 VVVDLVSQCRTYKQRVVHLVNSTSDESMLCQG-LALNDDLQRLLAKHEAIASGNS 266
>CE27055 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 403
Score = 77.4 bits (189), Expect = 6e-14
Identities = 76/315 (24%), Positives = 145/315 (45%), Gaps = 49/315 (15%)
Query: 16 PQSDPLTRKIQRACRISL-PEPDLALNLDVADYINDKQGAAPREAAISIVRLIN---SRD 71
P + P+ RKI+ A +L + LN+++ D+IN + PR+A ++ + ++ S++
Sbjct: 34 PFATPVGRKIELATDANLLATENWGLNMEICDFINGTEDG-PRDAVRALKKRLHNAMSKN 92
Query: 72 THTAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFP---ERPPVRFSKVQRLILTA 128
++ L++L+ VKNC + FH+ + K+F+ +L+K + P + +Q +L+
Sbjct: 93 NAVVMYTLTVLETAVKNCNHHFHVLVCNKDFVQDLIKLIGPKFDAPQI----IQERVLSL 148
Query: 129 IEEWYQTICKHSAYKED--MGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEI 186
I+ W A++ D + + + LK KG FP + DL L P +KTP
Sbjct: 149 IQAW------ADAFRGDPTLAGVVQSYDDLKSKGVEFP---AADLDTLAP---IKTPKRT 196
Query: 187 QKEQEIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTKLRRKA 246
I + +G+ +L K+ A D + Q+ ++ E LT + +
Sbjct: 197 YDVLTIRE---------QGQEPISATPAQLTKLRADL--DVVNQNIKVFRETLTDVVPRK 245
Query: 247 DLLNEMLGTNDSPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVNQ 306
+ +E+ + + +L + R Q R +I +DE +LL ND++N
Sbjct: 246 ETADEL-----------QLLSDLNDTCRHMQQRVLDLIRYV-SNDEVTYELLMVNDSLNS 293
Query: 307 LVQKYDLLKAGHAGE 321
+ +KYD + GE
Sbjct: 294 VFEKYDRFVSNRDGE 308
>Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 540
Score = 74.3 bits (181), Expect = 5e-13
Identities = 54/188 (28%), Positives = 91/188 (47%), Gaps = 15/188 (7%)
Query: 18 SDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAIF 77
++P + +++A D L LD+ D + + P++ SI+R +N +D H A+
Sbjct: 6 TNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSR-TGPKDCLRSIMRRVNHKDPHVAMQ 64
Query: 78 ALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTIC 137
AL+LL V NCG FHL++ ++F +E+ + P K++ L++ EW
Sbjct: 65 ALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMV----EW----- 115
Query: 138 KHSAYKED--MGYIRDMHRLLKYKGYTFPKINSE--DLAVLKPSEHLKTPSEIQKEQEIA 193
+K D + I M + LK +G TFP I S+ + A P+ K P + ++E
Sbjct: 116 -TDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEE 174
Query: 194 QAAKLEEL 201
AK EL
Sbjct: 175 DLAKAIEL 182
>At2g38410 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 671
Score = 70.5 bits (171), Expect = 7e-12
Identities = 76/335 (22%), Positives = 136/335 (39%), Gaps = 48/335 (14%)
Query: 14 MQPQSDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTH 73
M S T + +A L PD N+++ D +N A ++ ++ + + + +
Sbjct: 1 MASSSASATVAVDKATSDLLLGPDWTTNMEICDSVNSLHWQA-KDVVKAVKKRLQHKSSR 59
Query: 74 TAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWY 133
+ AL+LL+ LVKNCG H Q++ K L E+VK ++ + +V+ IL ++ W
Sbjct: 60 VQLLALTLLETLVKNCGDYLHHQVAEKNILGEMVKIVKKKADM---QVRDKILVMVDSWQ 116
Query: 134 QTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKP---SEHLKTPSE----- 185
Q + D L+ G FP+ + + ++ P L+ P
Sbjct: 117 QAFGGPEGKYPQYYWAYDE---LRRSGVEFPRRSPDASPIITPPVSHPPLRQPQGGYGVP 173
Query: 186 --------------------IQKEQEIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKE 225
Q + QA + G P + +L + MA E
Sbjct: 174 PAGYGVHQAGYGVPQAGYGIPQAGYGVPQAGYGIPQVGYGMPSG--SSRRLDEAMATEVE 231
Query: 226 DNMIQSKQILNEELTKLRRKADLLNEMLGTNDSPD---IENETIVELYNALRSSQPRFQK 282
+ S + +R DLL +ML D D +++E IV+L RS+Q + +
Sbjct: 232 GLSLSS-------IESMRDVMDLLGDMLQAVDPSDREAVKDEVIVDLVERCRSNQKKLMQ 284
Query: 283 IIEEEHDDDEFVQDLLKFNDTVNQLVQKYDLLKAG 317
++ DDE + L ND++ L+ K+D + +G
Sbjct: 285 MLTST-GDDELLGRGLDLNDSLQILLAKHDAIASG 318
>At1g21380 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 506
Score = 68.6 bits (166), Expect = 3e-11
Identities = 69/290 (23%), Positives = 125/290 (42%), Gaps = 38/290 (13%)
Query: 26 QRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAIFALSLLDVL 85
+RA L PD A+N+++ D IN + A +EA + + + S+++ I AL L+ L
Sbjct: 10 ERATNDMLIGPDWAINIELCDIINMEPSQA-KEAVKVLKKRLGSKNSKVQILALYALETL 68
Query: 86 VKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTICKHSAYKED 145
KNCG + I ++ L ++VK ++P + V+ IL+ ++ W Q S +
Sbjct: 69 SKNCGESVYQLIVDRDILPDMVKIVKKKPDL---TVREKILSLLDTW-QEAFGGSGGRFP 124
Query: 146 MGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKEQEIAQAAKLEELIRRG 205
Y + + L+ G FP + P Q + +AQA +E
Sbjct: 125 QYY--NAYNELRSAGIEFPPRTESSVPFFTPP---------QTQPIVAQATASDE----- 168
Query: 206 KPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTKLRRKADLLNEMLGTND---SPDIE 262
+ A + D+ + + EE+ + D+L +MLG D ++
Sbjct: 169 ----------DAAIQASLQSDD---ASALSMEEIQSAQGSVDVLTDMLGALDPSHPEGLK 215
Query: 263 NETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVNQLVQKYD 312
E IV+L R+ Q R ++ D++ Q L ND + +++Q +D
Sbjct: 216 EELIVDLVEQCRTYQRRVMALVNTTSDEELMCQG-LALNDNLQRVLQHHD 264
>Hs4885639 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 476
Score = 67.0 bits (162), Expect = 7e-11
Identities = 80/308 (25%), Positives = 133/308 (42%), Gaps = 44/308 (14%)
Query: 16 PQSDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTA 75
P + + I++A + D + + D IN Q A P++A ++ + I+ H
Sbjct: 10 PYATSVGHLIEKATFAGVQTEDWGQFMHICDIINTTQDA-PKDAVKALKKRISKNYNHKE 68
Query: 76 I-FALSLLDVLVKNCGYPFHLQISRKEFLNE-LVKRFPERPPVRFSKVQRLILTAIEEWY 133
I LSL+D+ V+NCG F I +KEF+ E LVK R + +Q IL I+ W
Sbjct: 69 IQLTLSLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLD-IQNRILNFIKTWS 127
Query: 134 QTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKE---Q 190
Q D+ +++++ L KG FP PSE + E Q
Sbjct: 128 QGF----PGGVDVSEVKEVYLDLVKKGVQFP------------------PSEAEAETARQ 165
Query: 191 EIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNMIQSKQI--LNEELTKLRRKADL 248
E AQ I P + A L V+A + +QI L+ EL ++ +
Sbjct: 166 ETAQ-------ISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRV 218
Query: 249 LNEMLGTNDSPDIEN----ETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTV 304
++ +L N +P EN E + +LY R Q R ++ ++D V +L++ N+ +
Sbjct: 219 MSAILMEN-TPGSENHEDIELLQKLYKTGREMQERIMDLLVVVENEDVTV-ELIQVNEDL 276
Query: 305 NQLVQKYD 312
N + Y+
Sbjct: 277 NNAILGYE 284
>7297777 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 689
Score = 65.9 bits (159), Expect = 2e-10
Identities = 47/197 (23%), Positives = 93/197 (46%), Gaps = 13/197 (6%)
Query: 17 QSDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAI 76
QS P +++A + + +L LDV D + A ++ +++R + D H +
Sbjct: 6 QSSPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLA-KDCLKAVMRRMGHTDPHVVM 64
Query: 77 FALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTI 136
A++LLD L NCG P HL+++ ++F E + + P KV + ++ W +
Sbjct: 65 QAITLLDALSNNCGKPLHLEVASRDFETEFRRLLAKAQP----KVSLKMRQVLKNWAEND 120
Query: 137 CKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVL--KPSEHLKTPSEI---QKEQE 191
K+ ++ I ++ L+ +GY F + + + K + K P+ + Q+E +
Sbjct: 121 YKND---RELDLIPALYAKLRQEGYDFKNLGDKTSKTVAEKAAALPKDPNVVSSQQEEDD 177
Query: 192 IAQAAKLEELIRRGKPE 208
IA+A +L +G P+
Sbjct: 178 IAKAIELSLKENKGSPK 194
>Hs4758528 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 777
Score = 65.1 bits (157), Expect = 3e-10
Identities = 42/154 (27%), Positives = 75/154 (48%), Gaps = 10/154 (6%)
Query: 18 SDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAI-SIVRLINSRDTHTAI 76
S R + +A L E D L + D I +QG + A+ SI + +N ++ H A+
Sbjct: 5 SGTFERLLDKATSQLLLETDWESILQICDLI--RQGDTQAKYAVNSIKKKVNDKNPHVAL 62
Query: 77 FALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTI 136
+AL +++ +VKNCG H +++ K+ + EL + V V+ IL I+ W
Sbjct: 63 YALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEV---NVRNKILYLIQAWAHAF 119
Query: 137 CKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSED 170
YK ++D ++++K +G+ FP+ D
Sbjct: 120 RNEPKYK----VVQDTYQIMKVEGHVFPEFKESD 149
>At5g16880 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 407
Score = 63.9 bits (154), Expect = 6e-10
Identities = 68/306 (22%), Positives = 133/306 (43%), Gaps = 36/306 (11%)
Query: 11 VRRMQPQSDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSR 70
V+ + +P + ++ A +L EPD +NL++ D IN ++ E I + I +
Sbjct: 38 VKELFQGPNPTDKIVEDATTENLEEPDWDMNLEICDMIN-QETINSVELIRGIKKRIMMK 96
Query: 71 DTHTAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIE 130
AL LL+ VKNC F +++ + L+E+VK + V ++ + L+L IE
Sbjct: 97 QPRIQYLALVLLETCVKNCEKAFS-EVAAERVLDEMVKLIDDPQTVVNNRNKALML--IE 153
Query: 131 EWYQTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLA-VLKPSEHLKTPSEIQKE 189
W ++ ++ + + ++ LK +G FP ++E LA + P+ P
Sbjct: 154 AWGES----TSELRYLPVFEETYKSLKARGIRFPGRDNESLAPIFTPARSTPAPE----- 204
Query: 190 QEIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNMIQS--KQILNEELTKLRRKAD 247
+ P+ + E A + D ++S + E R +
Sbjct: 205 ------------LNADLPQHVHEP-------AHIQYDVPVRSFTAEQTKEAFDIARNSIE 245
Query: 248 LLNEMLGTNDSPD-IENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVNQ 306
LL+ +L ++ D ++++ L R SQ Q+IIE +++ + + L ND + +
Sbjct: 246 LLSTVLSSSPQHDALQDDLTTTLVQQCRQSQTTVQRIIETAGENEALLFEALNVNDELVK 305
Query: 307 LVQKYD 312
+ KY+
Sbjct: 306 TLSKYE 311
>Hs14719400 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylation factor
effector GGA
Length = 690
Score = 62.8 bits (151), Expect = 1e-09
Identities = 52/204 (25%), Positives = 96/204 (46%), Gaps = 19/204 (9%)
Query: 120 KVQRLILTAIEEWYQTICKHSAYKEDMGYIRDMHRLLKYKGY--TFPKINSEDLAVLKPS 177
KV+ ++ + W + + + I+D + +LK +G + P I + + P
Sbjct: 76 KVKTKVIELLYSWTMALPEEAK-------IKDAYHMLKRQGIVQSDPPIPVDRTLIPSPP 128
Query: 178 EHLKTPSEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKEDNM-IQSKQILN 236
K P +E+ + L +L++ P+DL+EANKL+K M KED IQ
Sbjct: 129 PRPKNPVFDDEEK----SKLLAKLLKSKNPDDLQEANKLIKSMV--KEDEARIQKVTKRL 182
Query: 237 EELTKLRRKADLLNEML---GTNDSPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEF 293
L ++ LL+EML DS D + E + EL++ + + K+ E D+D
Sbjct: 183 HTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNS 242
Query: 294 VQDLLKFNDTVNQLVQKYDLLKAG 317
+ D+L+ +D +++++ Y + G
Sbjct: 243 LGDILQASDNLSRVINSYKTIIEG 266
>CE03788 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylation factor
effector GGA
Length = 522
Score = 61.6 bits (148), Expect = 3e-09
Identities = 68/286 (23%), Positives = 123/286 (42%), Gaps = 36/286 (12%)
Query: 51 KQGAAPREAAISIVRLINSRDTHTAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRF 110
KQ A+ A ++S A+ + LD LV+N G H + R +FLNELV+
Sbjct: 39 KQPASALLAVDLFSHKLSSPSQEEAMLTIRALDYLVRNGGEKVHERCGRYKFLNELVRLI 98
Query: 111 PERPPVRFSK--VQRLILTAIEEWYQTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINS 168
+ + + ++ I+ + W +I YK+ Y+ KI +
Sbjct: 99 APKYNGKLTSDALKTEIIKLLFIWQLSIKHIPKYKQ------------VYESLKLSKIIT 146
Query: 169 EDLAVLKPSEHLKTPSEIQKE--QEIAQAAKLEELIRRGKPEDLREANKLMKVMAGFKED 226
+D V + + ++ QA L+ L+ +PEDL AN L+K + +E
Sbjct: 147 DDPHVRETEVPVFAVPPVRSSVFDNEEQAVLLKALLSSNRPEDLETANNLIKTLVETEEH 206
Query: 227 NMIQSKQILNEELTKLRRKADLLNEM-------------LGTNDSPDIENETIVELYNAL 273
+++ ++E KL +L N++ LG N SPD E T+ + N L
Sbjct: 207 KLVK----IHERRKKLDHAINLCNQVEHLRLDKAAETIGLG-NYSPDNE-LTLQRVTNEL 260
Query: 274 RSSQPRFQKIIEE-EHDDDEFVQDLLKFNDTVNQLVQKYDLLKAGH 318
Q F + E ++D ++++L ND +N+++ + + K G+
Sbjct: 261 IQLQELFYGYVNELAENNDPCLEEVLNINDQINRVLPENETPKCGN 306
>7291071 [U] KOG1086 Cytosolic sorting protein/ADP-ribosylation factor
effector GGA
Length = 576
Score = 60.8 bits (146), Expect = 5e-09
Identities = 67/268 (25%), Positives = 117/268 (43%), Gaps = 46/268 (17%)
Query: 63 IVRLINSRDTHTA--IFALSLLDVLVKNCGYPFHLQISRKEFLNELVK------RFPERP 114
IV N++ H A + LL+ + CG F + S+ FLNEL++ + E P
Sbjct: 4 IVVKSNAQLVHKAQEMIVAKLLEECMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETP 63
Query: 115 PVRFSKVQRLILTAIEEWYQTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVL 174
+V++ I+ + W + IRD + +L+ +G
Sbjct: 64 ----HEVKQRIMECLLLWTTEFPQRQK-------IRDAYDMLRKEG-------------- 98
Query: 175 KPSEHLKTPSEIQKEQEI---AQAAKLEELIRRGKPEDLREANKLMK---VMAGFKEDNM 228
EH T + + K + + A +LI+ PE+ + AN L++ + D +
Sbjct: 99 -DIEHGTTEAAVAKRESVLGTIDEAMFAKLIKSNNPENFKRANLLLQYRMAQEARRNDLL 157
Query: 229 IQSKQILNEELTKLRRKADLLNEMLGTNDSPDIE-NETIVELYNALRSSQPRFQKIIEEE 287
Q + +L E ++ LLN+ML T D + + +ET+ ELY + + +P FQ + +
Sbjct: 158 AQHRLVLCE----VQETMQLLNQMLDTYDPANQDVSETLHELYKSCKKHKPIFQHLPQLL 213
Query: 288 HDDD-EFVQDLLKFNDTVNQLVQKYDLL 314
D D + V D L N + +Q+Y LL
Sbjct: 214 DDSDAQLVADTLDANCALLATMQRYKLL 241
>At5g01760 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 539
Score = 60.1 bits (144), Expect = 9e-09
Identities = 60/304 (19%), Positives = 126/304 (40%), Gaps = 45/304 (14%)
Query: 21 LTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAIFALS 80
+T + +A L PD + + + D +N + ++A ++ R + + + + L+
Sbjct: 22 VTVAVDKATSELLRTPDWTIIIAICDSLNSNRWQC-KDAIKAVKRRLQHKSSRVQLLTLT 80
Query: 81 LLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTI---- 136
++KNCG H I+ K L ++VK ++ +V+ +L ++ W +
Sbjct: 81 ---AMLKNCGDFVHSHIAEKHLLEDMVKLVRKKGDF---EVRNKLLILLDTWNEAFSGVA 134
Query: 137 CKHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKEQEIAQAA 196
CKH Y ++ LK G FP+ + E +L+P + T S +
Sbjct: 135 CKHPHYNW-------AYQELKRCGVKFPQRSKEAPLMLEPPPPV-TQSSSSSSMNLMSIG 186
Query: 197 KLEELIRRGKPEDLREANKLMKVMAGFKEDNMIQSKQILNEELTKLRRKADLLNEM---L 253
L E + + + L +R DL+N+M +
Sbjct: 187 SFRRL----------------------DETMATEIESLSLSSLESMRNVMDLVNDMVQAV 224
Query: 254 GTNDSPDIENETIVELYNALRSSQPRFQKIIEEEHDDDEFVQDLLKFNDTVNQLVQKYDL 313
+D +++E IV+L RS+Q + +++ D+D + L+ ND++ ++ ++D
Sbjct: 225 NPSDKSALKDELIVDLVEQCRSNQKKLIQMLTTTADEDVLARG-LELNDSLQVVLARHDA 283
Query: 314 LKAG 317
+ +G
Sbjct: 284 IASG 287
>Hs21265031 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 525
Score = 57.8 bits (138), Expect = 5e-08
Identities = 42/181 (23%), Positives = 88/181 (48%), Gaps = 10/181 (5%)
Query: 18 SDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAIF 77
++P + +++A D +L +D+ D + A ++ +I++ +N + H A+
Sbjct: 6 ANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGA-KDCLKAIMKRVNHKVPHVALQ 64
Query: 78 ALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTIC 137
AL+LL V NCG FHL++ ++F E+ + KV + + + EW +
Sbjct: 65 ALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNK---AHPKVCEKLKSLMVEWSEEFQ 121
Query: 138 KHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKEQEIAQAAK 197
K + I+ M K +G TFP S+ V +++ + ++ +++++IA+A +
Sbjct: 122 KDPQFSLISATIKSM----KEEGITFPPAGSQ--TVSAAAKNGTSSNKNKEDEDIAKAIE 175
Query: 198 L 198
L
Sbjct: 176 L 176
>CE06781 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 765
Score = 55.8 bits (133), Expect = 2e-07
Identities = 36/149 (24%), Positives = 66/149 (44%), Gaps = 10/149 (6%)
Query: 23 RKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRL-INSRDTHTAIFALSL 81
R + +A +L EP+ + D I + G P + ++ +R + + H L +
Sbjct: 43 RVLDQATDSTLVEPNWEGIILCTDMI--RSGEVPAKPSLQAIRKRMQHENPHVVNHTLLV 100
Query: 82 LDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTICKHSA 141
LD VKNCG+ H +++ +EF+ + E ++ +V+ L ++ W
Sbjct: 101 LDACVKNCGHKVHAEVATREFMEDFKNLVTEN---KYDEVKNKSLEMLQCWATAFANKPE 157
Query: 142 YKEDMGYIRDMHRLLKYKGYTFPKINSED 170
YK + D H L+K G+ FP + D
Sbjct: 158 YK----MVVDTHNLMKLAGFDFPSLKEAD 182
>HsM19923337 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 525
Score = 53.1 bits (126), Expect = 1e-06
Identities = 41/181 (22%), Positives = 86/181 (46%), Gaps = 10/181 (5%)
Query: 18 SDPLTRKIQRACRISLPEPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAIF 77
++P + +++A D +L +D+ D + A ++ +I++ +N + H A+
Sbjct: 6 ANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGA-KDCLKAIMKRVNHKVPHVALQ 64
Query: 78 ALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSKVQRLILTAIEEWYQTIC 137
AL+LL V NCG F L + ++F E+ + KV + + + EW +
Sbjct: 65 ALTLLGACVANCGKIFRLGVCSRDFATEVRAVIKNK---AHPKVCEKLKSLMVEWSEEFQ 121
Query: 138 KHSAYKEDMGYIRDMHRLLKYKGYTFPKINSEDLAVLKPSEHLKTPSEIQKEQEIAQAAK 197
K + I+ M K +G TFP S+ V +++ + ++ +++++IA+A +
Sbjct: 122 KDPQFSLISATIKSM----KEEGITFPPAGSQ--TVSAAAKNGTSSNKNKEDEDIAKAIE 175
Query: 198 L 198
L
Sbjct: 176 L 176
>At1g60070 [U] KOG1062 Vesicle coat complex AP-1 gamma subunit
Length = 867
Score = 52.8 bits (125), Expect = 1e-06
Identities = 44/137 (32%), Positives = 64/137 (46%), Gaps = 7/137 (5%)
Query: 446 DLLSEFSAPAVQHSTQPSIVSDRFLVNQSDVLKFEFAISRESES--TIKVTSFFSNVSIS 503
DLL F P S S + +S LK EF +++SE+ T + + F N++ +
Sbjct: 732 DLLDGFG-PTPPKSEDKSAAYPSIVAFESSSLKIEFNFTKQSENPQTTDIVANFINLTPN 790
Query: 504 QLTDLTLMLAVPKAQQLRLLPQSNTVLSSYAKDGIHQKSWIDNAVKNAPKPLRVKWKVSY 563
T+ AVPK QL L P S+ L A I Q + N+ K KP+ ++ +V Y
Sbjct: 791 VYTEFLFQAAVPKFLQLHLDPASSNSLP--ANGNIKQTMRVTNSQK-GKKPIVMRMRVGY 847
Query: 564 KANGVP-KEESAVYTFP 579
K NG EE + FP
Sbjct: 848 KINGKDVLEEGQINNFP 864
>CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 449
Score = 52.4 bits (124), Expect = 2e-06
Identities = 43/170 (25%), Positives = 77/170 (45%), Gaps = 16/170 (9%)
Query: 49 NDKQGAAPREAAISIVRLINSRDTHTAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVK 108
ND +G+ + S+ + +N+RD H + A+S+LD NC F ++S +F+NEL K
Sbjct: 33 NDFEGS--KTGIKSLRKRLNNRDPHVVLLAISVLDSCWANCEERFRKEVSSAQFINEL-K 89
Query: 109 RFPERPPVRFSKVQRLILTAIEEWYQTICKHSAYKEDMGYIRDMHRLLKYKGYTFPKINS 168
+ ++ RL +++W T CK ++ + I +H+ L GY+F +
Sbjct: 90 ALCTSSQRQVAEKMRL---TVQKWVDTECK---TEQSLSLIVTLHKNLVADGYSFVVDDP 143
Query: 169 EDLAVLKPSEHLKTPSEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMK 218
+ ++ P+ + QE EE I + L +A K K
Sbjct: 144 KSKTKAIDAKFANDPNYVGSAQE-------EEAIAKAIAASLADAEKQEK 186
>At1g23900 [U] KOG1062 Vesicle coat complex AP-1 gamma subunit
Length = 876
Score = 52.4 bits (124), Expect = 2e-06
Identities = 45/148 (30%), Positives = 67/148 (44%), Gaps = 7/148 (4%)
Query: 436 VQAQQDTHSNDLLSEFS-APAVQHSTQPSIVSDRFLVNQSDVLKFEFAISRESES--TIK 492
V T DLL S +P+ + + P+ + +S LK EF S+ + T
Sbjct: 729 VATTSSTGMFDLLDGLSPSPSKEATNGPAYAP--IVAYESSSLKIEFTFSKTPGNLQTTN 786
Query: 493 VTSFFSNVSISQLTDLTLMLAVPKAQQLRLLPQSNTVLSSYAKDGIHQKSWIDNAVKNAP 552
V + F+N+S + TD AVPK QL L P S+ L + I Q + N+ +
Sbjct: 787 VQATFTNLSPNTFTDFIFQAAVPKFLQLHLDPASSNTLLASGSGAITQNLRVTNS-QQGK 845
Query: 553 KPLRVKWKVSYKANGVP-KEESAVYTFP 579
K L ++ ++ YK NG EE V FP
Sbjct: 846 KSLVMRMRIGYKLNGKDVLEEGQVSNFP 873
>SPAC19A8.05c [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 610
Score = 50.4 bits (119), Expect = 7e-06
Identities = 42/144 (29%), Positives = 73/144 (50%), Gaps = 9/144 (6%)
Query: 25 IQRACRISLP--EPDLALNLDVADYINDKQGAAPREAAISIVRLINSRDTHTAIFALSLL 82
I++A +LP +++L L+++D I K P+ A + I+ + + I AL L
Sbjct: 15 IEKATSETLPAGSEEISLYLEISDQIRSKS-VDPKFAMRILKSRIDHSNPNVQIMALKLT 73
Query: 83 DVLVKNCGYPFHLQISRKEFLNELVKRFPERPPVRFSK-VQRLILTAIEEWYQTICKHSA 141
D VKN G F L+I+ +EF++ LV R P + V+ +IL I+ W + ++
Sbjct: 74 DTCVKNGGSGFLLEIASREFMDNLVSIL--RSPAGIDEDVKMVILRYIQSWALAVPDTNS 131
Query: 142 YKEDMGYIRDMHRLLKYKGYTFPK 165
+ YI +++ LK Y FP+
Sbjct: 132 ---PLSYIIHVYQNLKDGDYEFPE 152
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.133 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,714,896
Number of Sequences: 60738
Number of extensions: 1138563
Number of successful extensions: 4085
Number of sequences better than 1.0e-05: 30
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 4052
Number of HSP's gapped (non-prelim): 38
length of query: 581
length of database: 30,389,216
effective HSP length: 112
effective length of query: 469
effective length of database: 23,586,560
effective search space: 11062096640
effective search space used: 11062096640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)