ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV5645 check: MH T KOG0201 Signal transduction mechanisms Serine/threonine protein kinase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV5645 1939488 1936441 -1016
(1016 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YHR102w [T] KOG0201 Serine/threonine protein kinase 674 0.0
Hs20070158 [T] KOG0201 Serine/threonine protein kinase 291 3e-78
SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase 285 2e-76
HsM5454174 [T] KOG0201 Serine/threonine protein kinase 281 4e-75
Hs21361358 [T] KOG0201 Serine/threonine protein kinase 281 4e-75
7300224 [T] KOG0201 Serine/threonine protein kinase 274 6e-73
Hs15011880 [T] KOG0201 Serine/threonine protein kinase 268 4e-71
CE28674 [T] KOG0201 Serine/threonine protein kinase 267 7e-71
CE07510 [T] KOG0201 Serine/threonine protein kinase 267 7e-71
At1g53165 [T] KOG0201 Serine/threonine protein kinase 266 9e-71
At3g15220 [T] KOG0201 Serine/threonine protein kinase 258 4e-68
SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase 234 5e-61
CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 229 2e-59
CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 229 2e-59
CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 229 2e-59
Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 226 1e-58
7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 225 2e-58
HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 224 7e-58
Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 224 7e-58
Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 224 7e-58
Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 224 7e-58
At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 220 1e-56
YDR523c [T] KOG0201 Serine/threonine protein kinase 218 5e-56
SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase 216 1e-55
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 213 9e-55
Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST 211 5e-54
Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST 210 1e-53
7302458 [T] KOG0574 STE20-like serine/threonine kinase MST 204 7e-52
Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase 202 2e-51
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 201 6e-51
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 201 6e-51
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 201 6e-51
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 201 6e-51
Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase 200 1e-50
Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase k... 196 1e-49
Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and re... 196 2e-49
Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 196 2e-49
Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase k... 196 2e-49
HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase k... 195 3e-49
7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 194 6e-49
Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase 194 8e-49
At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase 193 1e-48
Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase 193 1e-48
Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase 192 2e-48
Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase k... 192 2e-48
At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase 192 2e-48
YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase 190 8e-48
7298926 [T] KOG0578 p21-activated serine/threonine protein kinase 190 8e-48
7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase 190 1e-47
Hs19923464 [T] KOG0577 Serine/threonine protein kinase 189 2e-47
CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 186 1e-46
At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase 185 3e-46
CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase 184 6e-46
At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase 184 6e-46
Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase 183 1e-45
Hs7706401 [T] KOG0577 Serine/threonine protein kinase 182 3e-45
Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 182 3e-45
Hs4759208 [T] KOG0577 Serine/threonine protein kinase 182 3e-45
SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein ... 180 9e-45
CE01405 [T] KOG0577 Serine/threonine protein kinase 180 9e-45
Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 180 1e-44
7293601 [T] KOG0577 Serine/threonine protein kinase 179 1e-44
CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase 179 2e-44
Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase 177 6e-44
Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase 171 4e-42
CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase 171 4e-42
At1g53570 [T] KOG0198 MEKK and related serine/threonine protein ... 171 5e-42
CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase 171 7e-42
CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase 171 7e-42
CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase 170 9e-42
At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase 170 9e-42
Hs14771959 [T] KOG0578 p21-activated serine/threonine protein ki... 169 2e-41
SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein... 168 3e-41
Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase 168 3e-41
At3g13530 [T] KOG0198 MEKK and related serine/threonine protein ... 167 1e-40
7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 166 2e-40
7300149 [T] KOG0578 p21-activated serine/threonine protein kinase 165 3e-40
YAR019c [T] KOG0198 MEKK and related serine/threonine protein ki... 165 4e-40
Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 165 4e-40
At5g66850 [T] KOG0198 MEKK and related serine/threonine protein ... 164 7e-40
At1g09000 [T] KOG0198 MEKK and related serine/threonine protein ... 162 2e-39
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 161 6e-39
At3g07980 [T] KOG0198 MEKK and related serine/threonine protein ... 161 6e-39
At1g63700 [T] KOG0198 MEKK and related serine/threonine protein ... 161 6e-39
Hs18602554 [T] KOG0578 p21-activated serine/threonine protein ki... 159 2e-38
At1g54960 [T] KOG0198 MEKK and related serine/threonine protein ... 157 6e-38
At1g23700 [T] KOG0582 Ste20-like serine/threonine protein kinase 155 4e-37
Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (... 152 3e-36
At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 151 4e-36
At3g06030 [T] KOG0198 MEKK and related serine/threonine protein ... 151 4e-36
Hs22065797 [T] KOG0577 Serine/threonine protein kinase 150 1e-35
YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase 150 1e-35
At1g79640 [T] KOG0582 Ste20-like serine/threonine protein kinase 150 1e-35
YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase 146 1e-34
At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 145 3e-34
Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 145 4e-34
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 145 4e-34
Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (... 144 5e-34
At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 144 7e-34
YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 142 2e-33
At4g08500 [T] KOG0198 MEKK and related serine/threonine protein ... 142 2e-33
YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 140 8e-33
YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 140 1e-32
Hs4506889 [T] KOG1006 Mitogen-activated protein kinase (MAPK) ki... 139 2e-32
SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase ... 139 2e-32
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 139 3e-32
Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein ... 139 3e-32
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 137 7e-32
SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protei... 137 7e-32
7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 137 9e-32
7292830 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 135 3e-31
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 135 4e-31
At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protei... 135 4e-31
Hs5453882 [G] KOG0599 Phosphorylase kinase gamma subunit 134 6e-31
CE10328 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 134 6e-31
Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 134 9e-31
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 133 1e-30
At4g08480 [T] KOG0198 MEKK and related serine/threonine protein ... 133 1e-30
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 132 3e-30
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 132 3e-30
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 131 5e-30
YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 131 6e-30
HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein... 130 1e-29
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 130 1e-29
Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neuro... 129 2e-29
7300559 [T] KOG4279 Serine/threonine protein kinase 129 2e-29
Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 129 3e-29
Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein... 128 4e-29
SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (... 127 7e-29
Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved... 127 9e-29
At5g19450 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 126 2e-28
Hs21729899 [T] KOG0581 Mitogen-activated protein kinase kinase (... 126 2e-28
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 126 2e-28
At4g08470 [T] KOG0198 MEKK and related serine/threonine protein ... 125 3e-28
At1g76040 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 125 3e-28
7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 125 3e-28
At4g32830 [D] KOG0580 Serine/threonine protein kinase 125 3e-28
At2g25880 [D] KOG0580 Serine/threonine protein kinase 125 4e-28
7299057 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 125 4e-28
CE27177 [T] KOG4279 Serine/threonine protein kinase 124 6e-28
YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 124 1e-27
Hs4759178 [D] KOG0580 Serine/threonine protein kinase 124 1e-27
Hs5174547 [T] KOG4279 Serine/threonine protein kinase 123 1e-27
Hs4507275 [D] KOG0580 Serine/threonine protein kinase 123 1e-27
CE07399 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 123 1e-27
Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 123 2e-27
ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase 123 2e-27
At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 123 2e-27
At4g04740 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 123 2e-27
At2g45490 [D] KOG0580 Serine/threonine protein kinase 123 2e-27
SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protei... 122 2e-27
Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 122 2e-27
At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 122 2e-27
7292829 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 122 2e-27
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 122 3e-27
At2g41860 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 122 3e-27
HsM4507279 [D] KOG0580 Serine/threonine protein kinase 122 4e-27
7293496 [R] KOG0597 Serine-threonine protein kinase FUSED 121 5e-27
7292679 [G] KOG0599 Phosphorylase kinase gamma subunit 121 5e-27
YPL209c [D] KOG0580 Serine/threonine protein kinase 121 6e-27
YNR031c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 121 6e-27
SPCC162.10 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 121 6e-27
Hs21735542 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 121 6e-27
At4g04720 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 121 6e-27
Hs4505785 [G] KOG0599 Phosphorylase kinase gamma subunit 120 1e-26
Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 120 1e-26
Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 120 1e-26
At5g25110 [T] KOG0583 Serine/threonine protein kinase 120 1e-26
YLR362w [T] KOG0198 MEKK and related serine/threonine protein ki... 120 1e-26
Hs4507273 [D] KOG0580 Serine/threonine protein kinase 120 1e-26
Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 120 1e-26
At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 120 1e-26
At3g20860 [R] KOG0589 Serine/threonine protein kinase 119 2e-26
At1g50700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 119 2e-26
At1g18890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 119 2e-26
CE29622 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 119 2e-26
At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 119 2e-26
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 118 5e-26
ECU07g0360 [D] KOG0580 Serine/threonine protein kinase 118 5e-26
Hs20550407 [T] KOG0201 Serine/threonine protein kinase 117 7e-26
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 117 9e-26
YPL150w [T] KOG0583 Serine/threonine protein kinase 117 1e-25
Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (... 117 1e-25
CE04724 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 117 1e-25
At5g45820 [T] KOG0583 Serine/threonine protein kinase 117 1e-25
At4g23650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 117 1e-25
At1g29230 [T] KOG0583 Serine/threonine protein kinase 117 1e-25
CE29092 [T] KOG0694 Serine/threonine protein kinase 116 2e-25
At4g18700 [T] KOG0583 Serine/threonine protein kinase 116 2e-25
7301213 [R] KOG0589 Serine/threonine protein kinase 116 2e-25
Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase 116 2e-25
At4g04700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 115 3e-25
At3g20410 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 115 3e-25
At2g34180 [T] KOG0583 Serine/threonine protein kinase 115 3e-25
SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase 115 3e-25
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 115 3e-25
At2g31500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 115 3e-25
SPACUNK12.02c [T] KOG0032 Ca2+/calmodulin-dependent protein kina... 115 5e-25
At5g01810 [T] KOG0583 Serine/threonine protein kinase 115 5e-25
At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 115 5e-25
CE27573 [T] KOG0198 MEKK and related serine/threonine protein ki... 114 6e-25
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 114 6e-25
CE07737 [T] KOG0198 MEKK and related serine/threonine protein ki... 114 6e-25
At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 114 6e-25
7299322 [R] KOG0611 Predicted serine/threonine protein kinase 114 6e-25
Hs4759044 [T] KOG0612 Rho-associated coiled-coil containing prot... 114 8e-25
Hs20536595 [T] KOG0612 Rho-associated coiled-coil containing pro... 114 8e-25
CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 114 8e-25
At4g21940 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 114 8e-25
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 114 8e-25
SPAC22E12.14c [RT] KOG0598 Ribosomal protein S6 kinase and relat... 114 1e-24
SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-speci... 114 1e-24
CE23001 [R] KOG0589 Serine/threonine protein kinase 114 1e-24
At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 114 1e-24
7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 114 1e-24
YHR205w [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 113 1e-24
CE24941 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 113 1e-24
CE24761 [D] KOG0580 Serine/threonine protein kinase 113 1e-24
CE15235 [R] KOG0589 Serine/threonine protein kinase 113 1e-24
At5g19360 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 113 1e-24
At5g12180 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 113 1e-24
At4g26890 [T] KOG0198 MEKK and related serine/threonine protein ... 113 1e-24
At4g14580 [T] KOG0583 Serine/threonine protein kinase 113 1e-24
At3g57530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 113 1e-24
At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 113 1e-24
7299536 [D] KOG0580 Serine/threonine protein kinase 113 1e-24
CE28744 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 113 2e-24
CE16527 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 113 2e-24
CE08098 [T] KOG0612 Rho-associated coiled-coil containing protei... 112 2e-24
At1g61950 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 112 2e-24
Hs4506067 [T] KOG0696 Serine/threonine protein kinase 112 3e-24
CE28218 [D] KOG0588 Serine/threonine protein kinase 112 3e-24
CE27768 [R] KOG0586 Serine/threonine protein kinase 112 3e-24
CE23838 [R] KOG0586 Serine/threonine protein kinase 112 3e-24
At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved... 112 3e-24
SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (... 112 4e-24
Hs4885583 [T] KOG0612 Rho-associated coiled-coil containing prot... 112 4e-24
CE25437 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 112 4e-24
At2g30040 [T] KOG0198 MEKK and related serine/threonine protein ... 112 4e-24
7294770 [T] KOG0603 Ribosomal protein S6 kinase 112 4e-24
Hs4885563 [T] KOG0694 Serine/threonine protein kinase 111 5e-24
At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 111 5e-24
Hs5453976 [T] KOG0694 Serine/threonine protein kinase 111 7e-24
CE18699 [T] KOG0694 Serine/threonine protein kinase 111 7e-24
CE05507 [T] KOG0603 Ribosomal protein S6 kinase 111 7e-24
At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 111 7e-24
Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PK... 110 9e-24
At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 110 9e-24
At1g74740 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 110 9e-24
Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine prote... 110 9e-24
Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase 110 1e-23
Hs4758702 [T] KOG4279 Serine/threonine protein kinase 110 1e-23
Hs4758194 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 110 1e-23
Hs21618351 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 110 1e-23
Hs21618349 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 110 1e-23
Hs21618347 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 110 1e-23
CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 110 1e-23
CE02604 [T] KOG0695 Serine/threonine protein kinase 110 1e-23
YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase 110 1e-23
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 110 1e-23
Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase 110 1e-23
At5g58380 [T] KOG0583 Serine/threonine protein kinase 110 1e-23
At1g02970 [D] KOG0601 Cyclin-dependent kinase WEE1 110 1e-23
7301734 [T] KOG0694 Serine/threonine protein kinase 110 1e-23
HsM4506099 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 109 2e-23
7299160 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 109 2e-23
SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase 109 2e-23
Hs4506057 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 108 3e-23
At3g51850 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 108 3e-23
At2g30360 [T] KOG0583 Serine/threonine protein kinase 108 3e-23
At1g49580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 108 3e-23
7296128 [T] KOG0583 Serine/threonine protein kinase 108 3e-23
Hs13899225 [R] KOG0586 Serine/threonine protein kinase 108 4e-23
CE07458 [T] KOG0583 Serine/threonine protein kinase 108 4e-23
At3g23000 [T] KOG0583 Serine/threonine protein kinase 108 4e-23
At2g38910 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 108 4e-23
At1g12580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 108 4e-23
YKL126w [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 108 6e-23
SPCC24B10.07 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 108 6e-23
HsM4885147 [T] KOG0201 Serine/threonine protein kinase 108 6e-23
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 108 6e-23
At5g45810 [T] KOG0583 Serine/threonine protein kinase 108 6e-23
At3g04810 [R] KOG0589 Serine/threonine protein kinase 108 6e-23
7302464 [R] KOG0586 Serine/threonine protein kinase 108 6e-23
Hs15619015 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 107 7e-23
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 107 7e-23
At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GT... 107 7e-23
At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 107 7e-23
At1g07150 [T] KOG0198 MEKK and related serine/threonine protein ... 107 7e-23
7295426 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 107 7e-23
Hs4502567_1 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase... 107 7e-23
CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase 107 7e-23
SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related... 107 9e-23
Hs9845489 [R] KOG0586 Serine/threonine protein kinase 107 9e-23
Hs9845487 [R] KOG0586 Serine/threonine protein kinase 107 9e-23
Hs4502709 [R] KOG0594 Protein kinase PCTAIRE and related kinases 107 9e-23
Hs22062450 [R] KOG0586 Serine/threonine protein kinase 107 9e-23
CE28643 [T] KOG0583 Serine/threonine protein kinase 107 9e-23
CE17429 [T] KOG0194 Protein tyrosine kinase 107 9e-23
7290150 [T] KOG0583 Serine/threonine protein kinase 107 9e-23
SPBC12D12.04c [T] KOG0694 Serine/threonine protein kinase 107 1e-22
Hs8923922 [R] KOG0586 Serine/threonine protein kinase 107 1e-22
Hs7657214 [T] KOG0583 Serine/threonine protein kinase 107 1e-22
Hs4506739 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 107 1e-22
Hs22035598 [T] KOG0201 Serine/threonine protein kinase 107 1e-22
At4g38230 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 107 1e-22
At2g31010 [T] KOG0192 Tyrosine kinase specific for activated (GT... 107 1e-22
At2g26980 [T] KOG0583 Serine/threonine protein kinase 107 1e-22
7297611 [T] KOG0614 cGMP-dependent protein kinase 107 1e-22
7290629 [T] KOG0604 MAP kinase-activated protein kinase 2 107 1e-22
YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 106 2e-22
Hs8923754 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 106 2e-22
Hs13376582 [T] KOG0198 MEKK and related serine/threonine protein... 106 2e-22
CE21025 [D] KOG0580 Serine/threonine protein kinase 106 2e-22
CE03232 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 106 2e-22
7303211 [T] KOG4717 Serine/threonine protein kinase 106 2e-22
7302861 [T] KOG0696 Serine/threonine protein kinase 106 2e-22
7296450 [D] KOG0575 Polo-like serine/threonine protein kinase 106 2e-22
Hs5453972 [T] KOG0694 Serine/threonine protein kinase 106 2e-22
Hs4507361 [T] KOG0192 Tyrosine kinase specific for activated (GT... 106 2e-22
Hs21735566 [T] KOG0192 Tyrosine kinase specific for activated (G... 106 2e-22
Hs21735564 [T] KOG0192 Tyrosine kinase specific for activated (G... 106 2e-22
Hs21735562 [T] KOG0192 Tyrosine kinase specific for activated (G... 106 2e-22
CE17284 [T] KOG0583 Serine/threonine protein kinase 106 2e-22
CE27894_1 [R] KOG0589 Serine/threonine protein kinase 106 2e-22
YMR104c [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 105 3e-22
Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE 105 3e-22
Hs5453966 [T] KOG0583 Serine/threonine protein kinase 105 3e-22
Hs20545357 [T] KOG0583 Serine/threonine protein kinase 105 3e-22
At5g10930 [T] KOG0583 Serine/threonine protein kinase 105 3e-22
At4g30960 [T] KOG0583 Serine/threonine protein kinase 105 3e-22
At3g58640 [T] KOG0192 Tyrosine kinase specific for activated (GT... 105 3e-22
At1g12680 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 105 3e-22
7293666 [D] KOG0575 Polo-like serine/threonine protein kinase 105 3e-22
SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 105 4e-22
HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase 105 4e-22
CE27902 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 105 4e-22
At5g28290 [R] KOG0589 Serine/threonine protein kinase 105 4e-22
At2g17290 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 105 4e-22
Hs5453978 [T] KOG0614 cGMP-dependent protein kinase 105 5e-22
Hs5453964 [T] KOG0583 Serine/threonine protein kinase 105 5e-22
Hs4506737 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 105 5e-22
Hs20547878 [R] KOG0589 Serine/threonine protein kinase 105 5e-22
Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase 105 5e-22
At2g35890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 105 5e-22
7299438 [R] KOG0586 Serine/threonine protein kinase 105 5e-22
7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 105 5e-22
Hs4506735 [T] KOG0603 Ribosomal protein S6 kinase 104 6e-22
Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 104 6e-22
CE22045 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 104 6e-22
At1g54510 [R] KOG0589 Serine/threonine protein kinase 104 6e-22
7296166 [T] KOG0614 cGMP-dependent protein kinase 104 6e-22
Hs13027388 [T] KOG0582 Ste20-like serine/threonine protein kinase 104 8e-22
CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 104 8e-22
At5g41990 [R] KOG0584 Serine/threonine protein kinase 104 8e-22
At4g24400 [T] KOG0583 Serine/threonine protein kinase 104 8e-22
At2g42630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 104 8e-22
YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 103 1e-21
Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 103 1e-21
Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 103 1e-21
Hs4502023 [T] KOG0690 Serine/threonine protein kinase 103 1e-21
CE27297 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 103 1e-21
CE20493 [TR] KOG0606 Microtubule-associated serine/threonine kin... 103 1e-21
At4g36070 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 103 1e-21
At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 1e-21
SPCC74.03c [T] KOG0583 Serine/threonine protein kinase 103 1e-21
Hs7661974 [T] KOG0583 Serine/threonine protein kinase 103 1e-21
Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE 103 1e-21
Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase 103 1e-21
Hs20535816 [T] KOG0695 Serine/threonine protein kinase 103 1e-21
Hs10864650 [T] KOG0695 Serine/threonine protein kinase 103 1e-21
CE28479 [T] KOG0583 Serine/threonine protein kinase 103 1e-21
CE15475 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 103 1e-21
CE15473 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 103 1e-21
CE00847 [T] KOG0583 Serine/threonine protein kinase 103 1e-21
At5g35410 [T] KOG0583 Serine/threonine protein kinase 103 1e-21
At4g31170 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 1e-21
At3g29160 [T] KOG0583 Serine/threonine protein kinase 103 1e-21
SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 103 2e-21
Hs12711660 [R] KOG0584 Serine/threonine protein kinase 103 2e-21
At1g73660 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 2e-21
7302860 [T] KOG0696 Serine/threonine protein kinase 103 2e-21
7300650 [R] KOG0594 Protein kinase PCTAIRE and related kinases 103 2e-21
7297009 [R] KOG0593 Predicted protein kinase KKIAMRE 103 2e-21
YBL105c [T] KOG0694 Serine/threonine protein kinase 102 2e-21
HsM4505263 [T] KOG0192 Tyrosine kinase specific for activated (G... 102 2e-21
Hs4885061 [T] KOG0690 Serine/threonine protein kinase 102 2e-21
Hs4506055 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 102 2e-21
Hs22055520 [R] KOG0584 Serine/threonine protein kinase 102 2e-21
Hs21735550 [T] KOG0192 Tyrosine kinase specific for activated (G... 102 2e-21
At5g23580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 102 2e-21
At5g07070 [T] KOG0583 Serine/threonine protein kinase 102 2e-21
At2g25090 [T] KOG0583 Serine/threonine protein kinase 102 2e-21
At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GT... 102 2e-21
Hs14754789 [OUT] KOG0595 Serine/threonine-protein kinase involve... 102 3e-21
CE28571 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 102 3e-21
CE15612 [T] KOG0690 Serine/threonine protein kinase 102 3e-21
At5g66210 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 102 3e-21
At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GT... 102 3e-21
7290147 [T] KOG0583 Serine/threonine protein kinase 102 3e-21
SPBC32C12.03c [T] KOG0583 Serine/threonine protein kinase 102 4e-21
SPAC17G8.14c [T] KOG0694 Serine/threonine protein kinase 102 4e-21
Hs4506071 [T] KOG0695 Serine/threonine protein kinase 102 4e-21
CE17354 [T] KOG0694 Serine/threonine protein kinase 102 4e-21
CE17353 [T] KOG0694 Serine/threonine protein kinase 102 4e-21
At1g49180_1 [OUT] KOG0595 Serine/threonine-protein kinase involv... 102 4e-21
YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 101 5e-21
Hs13384594 [T] KOG0696 Serine/threonine protein kinase 101 5e-21
CE29298 [T] KOG0690 Serine/threonine protein kinase 101 5e-21
CE18646 [T] KOG0690 Serine/threonine protein kinase 101 5e-21
CE03979 [T] KOG0614 cGMP-dependent protein kinase 101 5e-21
At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GT... 101 5e-21
At4g09570 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 101 5e-21
At3g18750 [R] KOG0584 Serine/threonine protein kinase 101 5e-21
At2g32510 [T] KOG0198 MEKK and related serine/threonine protein ... 101 5e-21
At2g17890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 101 5e-21
7299437 [R] KOG0586 Serine/threonine protein kinase 101 5e-21
CE21239 [T] KOG0583 Serine/threonine protein kinase 101 7e-21
CE04603 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 101 7e-21
At3g56760 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 101 7e-21
At3g10660 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 101 7e-21
At3g01090 [T] KOG0583 Serine/threonine protein kinase 101 7e-21
At1g30270 [T] KOG0583 Serine/threonine protein kinase 101 7e-21
7302570 [R] KOG0586 Serine/threonine protein kinase 101 7e-21
7291742_1 [T] KOG0612 Rho-associated coiled-coil containing prot... 101 7e-21
SPCC63.08c [OUT] KOG0595 Serine/threonine-protein kinase involve... 100 9e-21
Hs22068916 [T] KOG0696 Serine/threonine protein kinase 100 9e-21
Hs20127450 [T] KOG0696 Serine/threonine protein kinase 100 9e-21
Hs10835242 [T] KOG0614 cGMP-dependent protein kinase 100 9e-21
CE06563 [T] KOG0194 Protein tyrosine kinase 100 9e-21
At5g39420 [D] KOG0600 Cdc2-related protein kinase 100 9e-21
YDR122w [T] KOG0583 Serine/threonine protein kinase 100 1e-20
Hs5453974 [T] KOG0694 Serine/threonine protein kinase 100 1e-20
CE00315 [R] KOG0594 Protein kinase PCTAIRE and related kinases 100 1e-20
At4g35310 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 1e-20
At4g23050 [T] KOG0192 Tyrosine kinase specific for activated (GT... 100 1e-20
7303915 [T] KOG0694 Serine/threonine protein kinase 100 1e-20
7303914 [T] KOG0694 Serine/threonine protein kinase 100 1e-20
7294265 [TR] KOG0606 Microtubule-associated serine/threonine kin... 100 1e-20
SPAC890.03 [T] KOG0583 Serine/threonine protein kinase 100 2e-20
CE28251 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 100 2e-20
At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 2e-20
At1g35670 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 2e-20
YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 100 2e-20
Hs4506073 [T] KOG0694 Serine/threonine protein kinase 100 2e-20
Hs14758219 [T] KOG0694 Serine/threonine protein kinase 100 2e-20
CE05274 [T] KOG0690 Serine/threonine protein kinase 100 2e-20
At5g57630 [T] KOG0583 Serine/threonine protein kinase 100 2e-20
At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 2e-20
At2g41140 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 2e-20
At1g08720 [T] KOG0192 Tyrosine kinase specific for activated (GT... 100 2e-20
7295585 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 100 2e-20
YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 99 3e-20
SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases 99 3e-20
Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase 99 3e-20
Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 99 3e-20
CE02586 [T] KOG0696 Serine/threonine protein kinase 99 3e-20
CE02377 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 99 3e-20
At5g04870 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 3e-20
YCL024w [T] KOG0583 Serine/threonine protein kinase 99 3e-20
SPAC2F3.15 [D] KOG0600 Cdc2-related protein kinase 99 3e-20
Hs14735945 [T] KOG0694 Serine/threonine protein kinase 99 3e-20
CE28675 [T] KOG0201 Serine/threonine protein kinase 99 3e-20
CE02291 [T] KOG0194 Protein tyrosine kinase 99 3e-20
CE02074 [T] KOG0986 G protein-coupled receptor kinase 99 3e-20
7303111 [T] KOG0695 Serine/threonine protein kinase 99 3e-20
YOL100w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 99 4e-20
YGL180w [OUT] KOG0595 Serine/threonine-protein kinase involved i... 99 4e-20
Hs4885549 [T] KOG0690 Serine/threonine protein kinase 99 4e-20
Hs4502557 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 4e-20
Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 4e-20
At4g04710 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 4e-20
At3g50720 [T] KOG0192 Tyrosine kinase specific for activated (GT... 99 4e-20
7294566 [T] KOG0612 Rho-associated coiled-coil containing protei... 99 4e-20
YNR047w [R] KOG0610 Putative serine/threonine protein kinase 98 6e-20
YDR507c [D] KOG0588 Serine/threonine protein kinase 98 6e-20
YDR490c [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 98 6e-20
HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase 98 6e-20
Hs4758700 [T] KOG0604 MAP kinase-activated protein kinase 2 98 6e-20
Hs21361643 [T] KOG4717 Serine/threonine protein kinase 98 6e-20
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 98 6e-20
Hs20543401 [TR] KOG0606 Microtubule-associated serine/threonine ... 98 6e-20
Hs20536136 [T] KOG0192 Tyrosine kinase specific for activated (G... 98 6e-20
Hs14149671 [TR] KOG0606 Microtubule-associated serine/threonine ... 98 6e-20
CE28057 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 98 6e-20
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 98 6e-20
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 98 6e-20
At5g11850 [T] KOG0192 Tyrosine kinase specific for activated (GT... 98 6e-20
Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE 98 7e-20
Hs4506401 [T] KOG0193 Serine/threonine protein kinase RAF 98 7e-20
Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase 98 7e-20
Hs17455844 [TR] KOG0606 Microtubule-associated serine/threonine ... 98 7e-20
CE28061 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 98 7e-20
CE28060 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 98 7e-20
CE28059 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 98 7e-20
CE28058 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 98 7e-20
CE28056 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 98 7e-20
CE28055 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 98 7e-20
CE28054 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 98 7e-20
CE28053 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 98 7e-20
>YHR102w [T] KOG0201 Serine/threonine protein kinase
Length = 1080
Score = 674 bits (1738), Expect = 0.0
Identities = 456/1107 (41%), Positives = 599/1107 (53%), Gaps = 170/1107 (15%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
LFKR E+IGRGKFGVVYK ++VKT +VYAIKVLNLD+ DEVED+++EIQFL+SLKQ N
Sbjct: 22 LFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISN 81
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
IT YYGSYL DT LW+IME+CAGGSLR+LLRPG I+EKYIGVIMRE+LVAL IH+DNVI
Sbjct: 82 ITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIHKDNVI 141
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAAN+LI N G+VKLCDFGVAAQ++Q+ L+RQTMAGTPYWMAPEVIMEGVYYDTKV
Sbjct: 142 HRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKV 201
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGIT YEIATGNPPYC +EA+RAMQ+I KSKPPRLE R YS LKEFIALCLDEDP
Sbjct: 202 DIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDP 261
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNE-QYKHE------EESHTSS 307
KER A++L KSK I+ K T T ILKELI+RYLLFR+KN+ +YK E E S S
Sbjct: 262 KERLSADDLLKSKFIRAHKATPTSILKELISRYLLFRDKNKNKYKIEGSIPENEPSKPSE 321
Query: 308 KQNPNSSIEGNASQDAGSFTEKEPE-----DIDIKWDFDSLSSREYILENDINVEAIPEE 362
P+ + G+ +Q + + + E + D+++KWDFDSLSS +YI+EN+IN++A+ E+
Sbjct: 322 APKPSQNGGGDEAQKSIASNDNEIKRVNEGDVEMKWDFDSLSSSDYIIENNINLDALAED 381
Query: 363 -ADWIKYSPQEVNYAYPEEEYY------NSNKPYFPYYQGSTIGRTFNNNPNT-AHLSTI 414
+W NYAYP+E+ Y ++ +P+ YQG+TIG+ + P T A ST+
Sbjct: 382 NNEWATAQHDLFNYAYPDEDSYYFDPTSHNTRPF--VYQGTTIGKGY---PGTIAQNSTL 436
Query: 415 QXXXXXXXXXXXXXXXXQHNTHFNKHYQHTTTGTANHLSRXXXXXXXXXSKRSETKASKQ 474
N + N Y + S SKR E+KA KQ
Sbjct: 437 NAPVT--------------NNYTNSKYPSKMVAGTTNTSGTHTAGPMTSSKRLESKAPKQ 482
Query: 475 LLQLFED------KPEEVYDFPKLSKTVSSFNI----QPNGTPHVDHD-------NDSRP 517
LL+LFED + + + PK+SK++SS N + + P + ++ N RP
Sbjct: 483 LLELFEDNEIITAENDVNTEAPKISKSISSLNAGNSSRDDFIPSISNEVNGNINNNKMRP 542
Query: 518 DM------RNLHSQSTPALSILQTNFKSNLAGPGSSSVXXXXXXX---------XXXXXX 562
+ N +SQSTPAL +LQT F GP +S +
Sbjct: 543 HLPPLSSGNNYYSQSTPALPLLQTKFNKTSKGPPTSGLTTAPTSIEIEIPEELPNSALPT 602
Query: 563 XVSKESVLTMNTKPRSSTV--------SSMSQKATPVLQRRPTVSGQ-----PSSQLTSL 609
S + VL +TK RSSTV SS+ K+ + RR TVS PS+
Sbjct: 603 PASADPVLIPSTKARSSTVTAGTPSSSSSIQYKSPSNVPRRLTVSNNRPEHCPSTITNQK 662
Query: 610 RSDIMNGINTNSKTPGNDDTNGINVPSTSSN--------NAPNVGAKNLFG-SNLTQARS 660
+ + S TP N + N S +S N+ +G N + L+ ++
Sbjct: 663 LGSAVASNSGISSTPNNSNNYNNNTDSENSRGSSGSNTANSTQMGITNPGNVTKLSTHKA 722
Query: 661 PSPTRALADV--SPEKKLLDSV---LHQSAVYSN--TPPVMKQMHTP---NDVLLQSMN- 709
SP+R L V SP +K S + ++ ++N PP MK M D+LLQ +N
Sbjct: 723 SSPSRPLFGVGTSPNRKPAGSPTQNIGHNSTHTNLAPPPTMKPMANSKDNKDILLQPLNS 782
Query: 710 ------------------TPAEKKETEGEPSRINRDFKKQHPHLKLQMPSPTTLVGSNKL 751
T + E E SR+N DFK+ +P+LKLQMP PT +V NKL
Sbjct: 783 IPSSSTLNTISGNSSNNLTSSNYFSNEKEGSRVNGDFKRNNPNLKLQMPLPTPVV-RNKL 841
Query: 752 LDSTTQLDDASHQHQPNSASTAPGAVTAQTVNQFGINTSNA-QISVAMTPVGEKR--FGD 808
LD T ++ P SA G T + +NQFG NTS+A I V+MTP+ EK FG
Sbjct: 842 LDPNTATSQ-NNNGMPGSA----GISTNENINQFGFNTSSASNIPVSMTPISEKHIDFGG 896
Query: 809 FTKPXXXXXXXXXXXXXXXXXNDHVYNPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 868
K ++H N
Sbjct: 897 KIK-----RSQSISNRKNSSASEHPLN-------------------------ILGSSVSG 926
Query: 869 XXXXXXXXXXXXXXNPGTSNGAISIP-SASTSAGPLPSVSMTPLSIPPXXXXXXXXXXXX 927
N G +N S+P SA+T + + S T +
Sbjct: 927 NVSGIGNNNVGSNNNSGPNN---SVPLSANTGNTTIKANSTTIATSSSAAASTTAPISQQ 983
Query: 928 XXXXXXXXXXISTMSALSSTTPSSLGFIMDPPPKSLSMDMFIDVHD-----DHRIDKKPI 982
I + +A ++ + +SLGF M PPP+SL M+MF+D+ R+D+KP
Sbjct: 984 TIPSGTQFNHILSSAATAANSVNSLGFGMCPPPQSLQMEMFLDLESFLPGKQRRVDRKPQ 1043
Query: 983 ALSELDSLLKMFEDGLTVIEQTLRSSL 1009
L EL++LL+MFE+GL IE L+ L
Sbjct: 1044 VLKELENLLQMFEEGLPCIEHALKEQL 1070
>Hs20070158 [T] KOG0201 Serine/threonine protein kinase
Length = 443
Score = 291 bits (746), Expect = 3e-78
Identities = 155/327 (47%), Positives = 216/327 (65%), Gaps = 17/327 (5%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
LF + E IG+G FG V+K +TQ+V AIK+++L+ EDE+EDI++EI LS +P
Sbjct: 35 LFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPY 93
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+T YYGSYL DTKLW+IMEY GGS LL PG ++E I I+REIL L +H + I
Sbjct: 94 VTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKI 153
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAAN+L++ +G VKL DFGVA QL+ + +KR T GTP+WMAPEVI + YD+K
Sbjct: 154 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-YDSKA 212
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGITA E+A G PP+ + ++ + +I K+ PP LEG YS+PLKEF+ CL+++P
Sbjct: 213 DIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-NYSKPLKEFVEACLNKEP 271
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNSS 314
RP A+EL K K I + T L ELI RY +++K E+ SS ++ ++
Sbjct: 272 SFRPTAKELLKHKFILR-NAKKTSYLTELIDRY-------KRWKAEQSHDDSSSEDSDAE 323
Query: 315 IEGNAS--QDAG----SFTEKEPEDID 335
+G AS D+G + EK+P++++
Sbjct: 324 TDGQASGGSDSGDWIFTIREKDPKNLE 350
>SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase
Length = 652
Score = 285 bits (730), Expect = 2e-76
Identities = 157/333 (47%), Positives = 211/333 (63%), Gaps = 21/333 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTP-- 73
+ + E++GRG +G VY+ T++ AIK+LNLD EDEV DI+KE+ LS LKQ+
Sbjct: 10 YTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQSDVE 69
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNV 133
NI Y+GSYL+ T LW+IM+YC GGS+RTL+ G I E I +I+RE L AL IH +
Sbjct: 70 NIIKYHGSYLVGTNLWIIMDYCHGGSVRTLMEAGPISEPCISLILRETLQALKFIHHAGI 129
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
IHRDIKAANIL++ +G+VKLCDFGVAA+L+ + KR T GTPYWMAPEVI +G Y+
Sbjct: 130 IHRDIKAANILVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQEYNVM 189
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDED 253
DIWSLGITAYEIATG+PP+ + RA+ +I + PPRL G +S LKEFIA CL +
Sbjct: 190 ADIWSLGITAYEIATGSPPHAKEDPFRAVYLIAHTAPPRLNG-NFSALLKEFIASCLQDV 248
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNS 313
P+ R + EL KSK IKQ S L ++ RY ++ ++ P +
Sbjct: 249 PQRRLDSSELLKSKFIKQYSRMSISELTNVVKRY--------------DTWQAAGGIPQT 294
Query: 314 SIEGNASQDAGSFTEKEPEDI---DIKWDFDSL 343
+ G + D GS ++E D D W+F ++
Sbjct: 295 LLLGEEADD-GSDPDQETSDTAASDDGWEFGTI 326
>HsM5454174 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 281 bits (719), Expect = 4e-75
Identities = 149/305 (48%), Positives = 197/305 (63%), Gaps = 13/305 (4%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
LF + + IG+G FG VYK T++V AIK+++L+ EDE+EDI++EI LS +P
Sbjct: 19 LFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPY 77
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
IT Y+GSYL TKLW+IMEY GGS LL+PG +EE YI I+REIL L +H + I
Sbjct: 78 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAAN+L++ G VKL DFGVA QL+ + +KR T GTP+WMAPEVI + YD K
Sbjct: 138 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-YDFKA 196
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGITA E+A G PP + +R + +I K+ PP LEG ++S+P KEF+ CL++DP
Sbjct: 197 DIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEG-QHSKPFKEFVEACLNKDP 255
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNSS 314
+ RP A+EL K K I + T L ELI RY + + E H + +S
Sbjct: 256 RFRPTAKELLKHKFITRYT-KKTSFLTELIDRY---------KRWKSEGHGEESSSEDSD 305
Query: 315 IEGNA 319
I+G A
Sbjct: 306 IDGEA 310
>Hs21361358 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 281 bits (719), Expect = 4e-75
Identities = 149/305 (48%), Positives = 197/305 (63%), Gaps = 13/305 (4%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
LF + + IG+G FG VYK T++V AIK+++L+ EDE+EDI++EI LS +P
Sbjct: 19 LFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPY 77
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
IT Y+GSYL TKLW+IMEY GGS LL+PG +EE YI I+REIL L +H + I
Sbjct: 78 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKI 137
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAAN+L++ G VKL DFGVA QL+ + +KR T GTP+WMAPEVI + YD K
Sbjct: 138 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-YDFKA 196
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGITA E+A G PP + +R + +I K+ PP LEG ++S+P KEF+ CL++DP
Sbjct: 197 DIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEG-QHSKPFKEFVEACLNKDP 255
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNSS 314
+ RP A+EL K K I + T L ELI RY + + E H + +S
Sbjct: 256 RFRPTAKELLKHKFITRYT-KKTSFLTELIDRY---------KRWKSEGHGEESSSEDSD 305
Query: 315 IEGNA 319
I+G A
Sbjct: 306 IDGEA 310
>7300224 [T] KOG0201 Serine/threonine protein kinase
Length = 642
Score = 274 bits (700), Expect = 6e-73
Identities = 140/308 (45%), Positives = 203/308 (65%), Gaps = 8/308 (2%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F ++E IG+G FG V+K +TQQV AIK+++L+ EDE++DI++EI LS +P
Sbjct: 12 IFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQC-DSPY 70
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+T YYGS+L TKLW+IMEY GGS L++ G EE +IG+I+RE+L L +H + +
Sbjct: 71 VTKYYGSFLKGTKLWIIMEYLGGGSALDLMKAGSFEEMHIGIILREVLKGLDYLHSERKL 130
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAAN+L++ G VKL DFGVA QL+ + KR T GTP+WMAPEVI + YD K
Sbjct: 131 HRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQS-QYDAKA 189
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGITA E+A G PP + +R + +I K+ PP+L G Y++ K+F+ CL++DP
Sbjct: 190 DIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPQLTG-SYTKSFKDFVEACLNKDP 248
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNSS 314
+ RP A+EL K IK+ K + +I +LI R F++ E E+ + + + + +
Sbjct: 249 ENRPTAKELLKYPFIKKAKKNAYLI--DLIDR---FKKWKVSKGDESETESENSDSDSDA 303
Query: 315 IEGNASQD 322
+G +SQD
Sbjct: 304 KQGGSSQD 311
>Hs15011880 [T] KOG0201 Serine/threonine protein kinase
Length = 416
Score = 268 bits (684), Expect = 4e-71
Identities = 148/321 (46%), Positives = 203/321 (63%), Gaps = 12/321 (3%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
LF + E IG+G FG V+K +TQQV AIK+++L+ EDE+EDI++EI LS +
Sbjct: 23 LFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSS-Y 81
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+T YYGSYL +KLW+IMEY GGS LLR G +E I +++EIL L +H + I
Sbjct: 82 VTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAAN+L++ G VKL DFGVA QL+ + +KR T GTP+WMAPEVI + YD+K
Sbjct: 142 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA-YDSKA 200
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGITA E+A G PP M +R + +I K+ PP L G ++++ KEFI CL++DP
Sbjct: 201 DIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG-DFTKSFKEFIDACLNKDP 259
Query: 255 KERPYAEELFKSK-LIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNS 313
RP A+EL K K ++K K TS L ELI R+ ++ + H ++ S + S
Sbjct: 260 SFRPTAKELLKHKFIVKNSKKTS--YLTELIDRFKRWKAEG----HSDDESDSEGSDSES 313
Query: 314 SIEGNASQDAGSFT--EKEPE 332
+ N + SFT K+P+
Sbjct: 314 TSRENNTHPEWSFTTVRKKPD 334
>CE28674 [T] KOG0201 Serine/threonine protein kinase
Length = 651
Score = 267 bits (682), Expect = 7e-71
Identities = 134/277 (48%), Positives = 192/277 (68%), Gaps = 4/277 (1%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F ++E IGRG FG VYK +T +V AIK+++L+ EDE+EDI++EIQ LS +
Sbjct: 31 IFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQC-DSQY 89
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+T Y+GS+L +KLW+IMEY GGS L + G ++E +I VI+REIL L +H + I
Sbjct: 90 VTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKI 149
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAAN+L++ +G VK+ DFGVA QL++++ KR T G+P+WMAPE+I + YD K
Sbjct: 150 HRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQS-SYDYKA 208
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGITA E+A G PP+ + +R + +I K+ PP L+G ++S+P KEF+ +CL++DP
Sbjct: 209 DIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDP 268
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFR 291
+ RP A L K + IK+ K S IL +LI R +R
Sbjct: 269 ENRPSASTLLKHQFIKRAKKNS--ILVDLIERAAEYR 303
>CE07510 [T] KOG0201 Serine/threonine protein kinase
Length = 653
Score = 267 bits (682), Expect = 7e-71
Identities = 134/277 (48%), Positives = 192/277 (68%), Gaps = 4/277 (1%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F ++E IGRG FG VYK +T +V AIK+++L+ EDE+EDI++EIQ LS +
Sbjct: 33 IFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQC-DSQY 91
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+T Y+GS+L +KLW+IMEY GGS L + G ++E +I VI+REIL L +H + I
Sbjct: 92 VTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKI 151
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAAN+L++ +G VK+ DFGVA QL++++ KR T G+P+WMAPE+I + YD K
Sbjct: 152 HRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQS-SYDYKA 210
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGITA E+A G PP+ + +R + +I K+ PP L+G ++S+P KEF+ +CL++DP
Sbjct: 211 DIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDP 270
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFR 291
+ RP A L K + IK+ K S IL +LI R +R
Sbjct: 271 ENRPSASTLLKHQFIKRAKKNS--ILVDLIERAAEYR 305
>At1g53165 [T] KOG0201 Serine/threonine protein kinase
Length = 1007
Score = 266 bits (681), Expect = 9e-71
Identities = 142/301 (47%), Positives = 200/301 (66%), Gaps = 12/301 (3%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
F + E+IGRG FG VYKAF + + AIKV++L+ +EDE+EDI+KEI LS + P I
Sbjct: 342 FSQFELIGRGSFGDVYKAFDTELNKDVAIKVIDLEESEDEIEDIQKEISVLSQCR-CPYI 400
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALISIHRDNVI 134
T YYGSYL TKLW+IMEY AGGS+ LL+PG ++E I I R++L A+ +H + I
Sbjct: 401 TEYYGSYLHQTKLWIIMEYMAGGSVADLLQPGNPLDEISIACITRDLLHAVEYLHAEGKI 460
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAANIL++ NG VK+ DFGV+AQL++++ +R+T GTP+WMAPEVI Y+ K
Sbjct: 461 HRDIKAANILLSENGDVKVADFGVSAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKA 520
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGIT E+A G PP + +R + +I + PP+L+ +S+PLKEF++ CL + P
Sbjct: 521 DIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLD-EHFSRPLKEFVSFCLKKAP 579
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNE-QYKHEEESHTSSKQNPNS 313
ERP A+EL K + IK + + ++ + RE+ + Q K +EE T+ + P
Sbjct: 580 AERPNAKELLKHRFIKNARKSPKLLER--------IRERPKYQVKEDEEIPTNGPKAPAE 631
Query: 314 S 314
S
Sbjct: 632 S 632
>At3g15220 [T] KOG0201 Serine/threonine protein kinase
Length = 690
Score = 258 bits (658), Expect = 4e-68
Identities = 144/333 (43%), Positives = 207/333 (61%), Gaps = 18/333 (5%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
F + E+IGRG FG VYKAF + AIKV++L+ +EDE+EDI+KEI LS + P I
Sbjct: 15 FSQIELIGRGSFGDVYKAFDKDLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCR-CPYI 73
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALISIHRDNVI 134
T YYGSYL TKLW+IMEY AGGS+ LL+ ++E I I R++L A+ +H + I
Sbjct: 74 TEYYGSYLHQTKLWIIMEYMAGGSVADLLQSNNPLDETSIACITRDLLHAVEYLHNEGKI 133
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAANIL++ NG VK+ DFGV+AQL++++ +R+T GTP+WMAPEVI Y+ K
Sbjct: 134 HRDIKAANILLSENGDVKVADFGVSAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKA 193
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGIT E+A G PP + +R + +I + PP+L+ +S+ +KEF++LCL + P
Sbjct: 194 DIWSLGITVIEMAKGEPPLADLHPMRVLFIIPRETPPQLD-EHFSRQVKEFVSLCLKKAP 252
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNE-QYKHEEESHTSSKQNPNS 313
ERP A+EL K + IK + + ++ + RE+ + Q K +EE+ + + P
Sbjct: 253 AERPSAKELIKHRFIKNARKSPKLLER--------IRERPKYQVKEDEETPRNGAKAPVE 304
Query: 314 S------IEGNASQDAGSFTEKEPEDIDIKWDF 340
S SQ A ++ + + WDF
Sbjct: 305 SSGTVRIARDERSQGAPGYSFQGNTVKNAGWDF 337
>SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase
Length = 312
Score = 234 bits (597), Expect = 5e-61
Identities = 128/329 (38%), Positives = 196/329 (58%), Gaps = 25/329 (7%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
++ ++IG+G FG V++A V++ ++ A+KV++LD T+D++E + +EI FL L +I
Sbjct: 6 YRDLQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSV-HI 64
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIHRDNVI 134
T YY S++ +LW+ MEYC GGS LL+ G E+ I +MR++L AL+ +H +
Sbjct: 65 TKYYASFVDGFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQGKM 124
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIKAANIL +G VKL DFGV+ QL K GTP+WMAPEV+ + Y+ K
Sbjct: 125 HRDIKAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVVKQ-TGYNYKA 183
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
DIWSLGITAYE+ATG PPY + ++ + +I K PP LE ++S+ +F++ CL ++P
Sbjct: 184 DIWSLGITAYELATGEPPYSGIHPMKVLLLIPKHSPPSLERSKFSRAFCDFVSNCLKKNP 243
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNSS 314
K+R AE L K K IK+ ++V KE++ Y ++ ES + P +S
Sbjct: 244 KDRATAEYLSKHKFIKKYCPNTSV--KEVVASYAKWK----------ESELLPEATPYNS 291
Query: 315 IEGNASQDAGSFTEKEPEDIDIKWDFDSL 343
GN++ ++ WDF ++
Sbjct: 292 TMGNSANTID----------EVVWDFGTV 310
>CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1096
Score = 229 bits (583), Expect = 2e-59
Identities = 134/387 (34%), Positives = 214/387 (54%), Gaps = 24/387 (6%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F+ E++G G +G VYK HVKT Q+ AIK++N++ EDE ++I+ EI L N
Sbjct: 20 IFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNIN--EDEEDEIKLEINMLKKHSHHRN 77
Query: 75 ITHYYGSYLIDT--------KLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILV 123
+ YYG+++ +LW++ME+C GS+ L++ G ++E++I I REIL
Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILR 137
Query: 124 ALISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEV 183
L +H+ VIHRDIK N+L+ ++ VKL DFGV+AQL +++ +R T GTPYWMAPEV
Sbjct: 138 GLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEV 197
Query: 184 I----MEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE-GREY 238
I YD++ D+WSLGITA E+A G+PP C M +RA+ +I ++ PP+L+ +++
Sbjct: 198 IACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKW 257
Query: 239 SQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV--ILKELITRYLLFREKNEQ 296
++ + FI L +D +RPY L + IK++ T+ +KE I R R K +
Sbjct: 258 TKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDRNR--RVKKDD 315
Query: 297 YKHEEESHTSSKQNPNSSIEGNASQDAGSFTEKEPEDIDIKWDFDSL--SSREYILENDI 354
+E + +PN+ +D + P D ++ F L SSR +
Sbjct: 316 ADYEYSGSEDDEPSPNNRGPSMGIRDDSESSSMIPMDNTLRKGFQKLQESSRGFAEPGAQ 375
Query: 355 NVEAIPEEADWIKYSPQEVNYAYPEEE 381
+ +P++ + Q+ Y P E
Sbjct: 376 QLRRLPQQPAPAPFQYQQSRYVEPRRE 402
>CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1082
Score = 229 bits (583), Expect = 2e-59
Identities = 134/387 (34%), Positives = 214/387 (54%), Gaps = 24/387 (6%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F+ E++G G +G VYK HVKT Q+ AIK++N++ EDE ++I+ EI L N
Sbjct: 20 IFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNIN--EDEEDEIKLEINMLKKHSHHRN 77
Query: 75 ITHYYGSYLIDT--------KLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILV 123
+ YYG+++ +LW++ME+C GS+ L++ G ++E++I I REIL
Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILR 137
Query: 124 ALISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEV 183
L +H+ VIHRDIK N+L+ ++ VKL DFGV+AQL +++ +R T GTPYWMAPEV
Sbjct: 138 GLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEV 197
Query: 184 I----MEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE-GREY 238
I YD++ D+WSLGITA E+A G+PP C M +RA+ +I ++ PP+L+ +++
Sbjct: 198 IACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKW 257
Query: 239 SQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV--ILKELITRYLLFREKNEQ 296
++ + FI L +D +RPY L + IK++ T+ +KE I R R K +
Sbjct: 258 TKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDRNR--RVKKDD 315
Query: 297 YKHEEESHTSSKQNPNSSIEGNASQDAGSFTEKEPEDIDIKWDFDSL--SSREYILENDI 354
+E + +PN+ +D + P D ++ F L SSR +
Sbjct: 316 ADYEYSGSEDDEPSPNNRGPSMGIRDDSESSSMIPMDNTLRKGFQKLQESSRGFAEPGAQ 375
Query: 355 NVEAIPEEADWIKYSPQEVNYAYPEEE 381
+ +P++ + Q+ Y P E
Sbjct: 376 QLRRLPQQPAPAPFQYQQSRYVEPRRE 402
>CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1087
Score = 229 bits (583), Expect = 2e-59
Identities = 134/387 (34%), Positives = 214/387 (54%), Gaps = 24/387 (6%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F+ E++G G +G VYK HVKT Q+ AIK++N++ EDE ++I+ EI L N
Sbjct: 20 IFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNIN--EDEEDEIKLEINMLKKHSHHRN 77
Query: 75 ITHYYGSYLIDT--------KLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILV 123
+ YYG+++ +LW++ME+C GS+ L++ G ++E++I I REIL
Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILR 137
Query: 124 ALISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEV 183
L +H+ VIHRDIK N+L+ ++ VKL DFGV+AQL +++ +R T GTPYWMAPEV
Sbjct: 138 GLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEV 197
Query: 184 I----MEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE-GREY 238
I YD++ D+WSLGITA E+A G+PP C M +RA+ +I ++ PP+L+ +++
Sbjct: 198 IACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKW 257
Query: 239 SQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV--ILKELITRYLLFREKNEQ 296
++ + FI L +D +RPY L + IK++ T+ +KE I R R K +
Sbjct: 258 TKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDRNR--RVKKDD 315
Query: 297 YKHEEESHTSSKQNPNSSIEGNASQDAGSFTEKEPEDIDIKWDFDSL--SSREYILENDI 354
+E + +PN+ +D + P D ++ F L SSR +
Sbjct: 316 ADYEYSGSEDDEPSPNNRGPSMGIRDDSESSSMIPMDNTLRKGFQKLQESSRGFAEPGAQ 375
Query: 355 NVEAIPEEADWIKYSPQEVNYAYPEEE 381
+ +P++ + Q+ Y P E
Sbjct: 376 QLRRLPQQPAPAPFQYQQSRYVEPRRE 402
>Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1295
Score = 226 bits (577), Expect = 1e-58
Identities = 140/366 (38%), Positives = 203/366 (55%), Gaps = 35/366 (9%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F+ E++G G +G VYK HVKT Q+ AIKV+ D TEDE E+I++EI L N
Sbjct: 24 IFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDEEEEIKQEINMLKKYSHHRN 81
Query: 75 ITHYYGSYLI------DTKLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILVAL 125
I YYG+++ D +LW++ME+C GS+ L++ ++E I I REIL L
Sbjct: 82 IATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGL 141
Query: 126 ISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM 185
+H VIHRDIK N+L+ N VKL DFGV+AQL +++ +R T GTPYWMAPEVI
Sbjct: 142 AHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 186 ----EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP 241
YD + DIWSLGITA E+A G PP C M +RA+ +I ++ PPRL+ +++S+
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKK 261
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIKQE--KGTSTVILKELITRYLLFREKNEQYKH 299
+FI CL + RP E+L K I+ + + + LK+ I R R + E+ ++
Sbjct: 262 FIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEY 321
Query: 300 EEESHTSSKQNPNSSIEGNASQDAGSFTEKEPEDIDIKWDFDSLSSREYI---LENDINV 356
E G+ +D E EP I + +S RE++ EN N
Sbjct: 322 E--------------YSGSEEEDDSHGEEGEPSSI-MNVPGESTLRREFLRLQQENKSNS 366
Query: 357 EAIPEE 362
EA+ ++
Sbjct: 367 EALKQQ 372
>7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 979
Score = 225 bits (574), Expect = 2e-58
Identities = 129/311 (41%), Positives = 182/311 (58%), Gaps = 21/311 (6%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F+ E++G G +G VYK H KT Q+ AIKV+ D TEDE E+I+ EI L N
Sbjct: 31 IFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVM--DVTEDEEEEIKLEINVLKKYSNHRN 88
Query: 75 ITHYYGSYLI------DTKLWVIMEYCAGGSLRTLLRPG---IIEEKYIGVIMREILVAL 125
I YYG+++ D +LW++MEYC GS+ L++ ++E++I I REIL L
Sbjct: 89 IATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGL 148
Query: 126 ISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM 185
+H + VIHRDIK N+L+ +N VKL DFGV+AQL +++ +R T GTPYWMAPEVI
Sbjct: 149 SYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIA 208
Query: 186 ----EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP 241
YD + D+WSLGITA E+A PP C + +RA+ +I ++ PPRL+ +++S+
Sbjct: 209 CDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKK 268
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV--ILKELITRYLLFREKNEQYKH 299
FI L +D +RPY E L K IK + V LK+ I R +K +Q K
Sbjct: 269 FHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRC----KKRKQEKE 324
Query: 300 EEESHTSSKQN 310
E+ S N
Sbjct: 325 REDYRYSGSDN 335
>HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1165
Score = 224 bits (570), Expect = 7e-58
Identities = 133/322 (41%), Positives = 190/322 (58%), Gaps = 23/322 (7%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F+ E++G G +G VYK HVKT Q+ AIKV+ D TEDE E+I+ EI L N
Sbjct: 24 IFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDEEEEIKLEINMLKKYSHHRN 81
Query: 75 ITHYYGSYLI------DTKLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILVAL 125
I YYG+++ D +LW++ME+C GS+ L++ ++E +I I REIL L
Sbjct: 82 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141
Query: 126 ISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM 185
+H +VIHRDIK N+L+ N VKL DFGV+AQL +++ +R T GTPYWMAPEVI
Sbjct: 142 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 186 ----EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP 241
YD + D+WS GITA E+A G PP C M +RA+ +I ++ PPRL+ +++S+
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKK 261
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV--ILKELITRYLLFR-EKNE-QY 297
FI CL ++ +RP E+L K I+ + V LK+ I R R EK+E +Y
Sbjct: 262 FFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEY 321
Query: 298 KH----EEESHTSSKQNPNSSI 315
++ EEE ++ SSI
Sbjct: 322 EYSGSEEEEEEVPEQEGEPSSI 343
>Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1212
Score = 224 bits (570), Expect = 7e-58
Identities = 133/322 (41%), Positives = 190/322 (58%), Gaps = 23/322 (7%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F+ E++G G +G VYK HVKT Q+ AIKV+ D TEDE E+I+ EI L N
Sbjct: 24 IFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDEEEEIKLEINMLKKYSHHRN 81
Query: 75 ITHYYGSYLI------DTKLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILVAL 125
I YYG+++ D +LW++ME+C GS+ L++ ++E +I I REIL L
Sbjct: 82 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141
Query: 126 ISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM 185
+H +VIHRDIK N+L+ N VKL DFGV+AQL +++ +R T GTPYWMAPEVI
Sbjct: 142 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 186 ----EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP 241
YD + D+WS GITA E+A G PP C M +RA+ +I ++ PPRL+ +++S+
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKK 261
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV--ILKELITRYLLFR-EKNE-QY 297
FI CL ++ +RP E+L K I+ + V LK+ I R R EK+E +Y
Sbjct: 262 FFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEY 321
Query: 298 KH----EEESHTSSKQNPNSSI 315
++ EEE ++ SSI
Sbjct: 322 EYSGSEEEEEEVPEQEGEPSSI 343
>Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1320
Score = 224 bits (570), Expect = 7e-58
Identities = 133/322 (41%), Positives = 190/322 (58%), Gaps = 23/322 (7%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F+ E++G G +G VYK HVKT Q+ AIKV+ D TEDE E+I+ EI L N
Sbjct: 24 IFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDEEEEIKLEINMLKKYSHHRN 81
Query: 75 ITHYYGSYLI------DTKLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILVAL 125
I YYG+++ D +LW++ME+C GS+ L++ ++E +I I REIL L
Sbjct: 82 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141
Query: 126 ISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM 185
+H +VIHRDIK N+L+ N VKL DFGV+AQL +++ +R T GTPYWMAPEVI
Sbjct: 142 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 186 ----EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP 241
YD + D+WS GITA E+A G PP C M +RA+ +I ++ PPRL+ +++S+
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKK 261
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV--ILKELITRYLLFR-EKNE-QY 297
FI CL ++ +RP E+L K I+ + V LK+ I R R EK+E +Y
Sbjct: 262 FFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEY 321
Query: 298 KH----EEESHTSSKQNPNSSI 315
++ EEE ++ SSI
Sbjct: 322 EYSGSEEEEEEVPEQEGEPSSI 343
>Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1166
Score = 224 bits (570), Expect = 7e-58
Identities = 133/322 (41%), Positives = 190/322 (58%), Gaps = 23/322 (7%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F+ E++G G +G VYK HVKT Q+ AIKV+ D TEDE E+I+ EI L N
Sbjct: 24 IFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDEEEEIKLEINMLKKYSHHRN 81
Query: 75 ITHYYGSYLI------DTKLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILVAL 125
I YYG+++ D +LW++ME+C GS+ L++ ++E +I I REIL L
Sbjct: 82 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141
Query: 126 ISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM 185
+H +VIHRDIK N+L+ N VKL DFGV+AQL +++ +R T GTPYWMAPEVI
Sbjct: 142 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 186 ----EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP 241
YD + D+WS GITA E+A G PP C M +RA+ +I ++ PPRL+ +++S+
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKK 261
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV--ILKELITRYLLFR-EKNE-QY 297
FI CL ++ +RP E+L K I+ + V LK+ I R R EK+E +Y
Sbjct: 262 FFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEY 321
Query: 298 KH----EEESHTSSKQNPNSSI 315
++ EEE ++ SSI
Sbjct: 322 EYSGSEEEEEEVPEQEGEPSSI 343
>At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 836
Score = 220 bits (560), Expect = 1e-56
Identities = 126/340 (37%), Positives = 193/340 (56%), Gaps = 17/340 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G+G +G VYKA +KT ++ A+KV++L E+ E+IR EI+ L PN+ Y GS
Sbjct: 255 LGKGSYGSVYKARDLKTSEIVAVKVISLTEGEEGYEEIRGEIEMLQQCNH-PNVVRYLGS 313
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLR--PGIIEEKYIGVIMREILVALISIHRDNVIHRDIK 139
Y + LW++MEYC GGS+ L+ +EE I I RE L L +H +HRDIK
Sbjct: 314 YQGEDYLWIVMEYCGGGSVADLMNVTEEALEEYQIAYICREALKGLAYLHSIYKVHRDIK 373
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSL 199
NIL+ G VKL DFGVAAQL+++M KR T GTP+WMAPEVI E YD KVD+W+L
Sbjct: 374 GGNILLTEQGEVKLGDFGVAAQLTRTMSKRNTFIGTPHWMAPEVIQEN-RYDGKVDVWAL 432
Query: 200 GITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKEFIALCLDEDPKERP 258
G++A E+A G PP + +R + MI+ P LE +E +S +F+A CL ++P+ RP
Sbjct: 433 GVSAIEMAEGLPPRSSVHPMRVLFMISIEPAPMLEDKEKWSLVFHDFVAKCLTKEPRLRP 492
Query: 259 YAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKH----EEESHTSSKQNPNSS 314
A E+ K K +++ K ++ + ++ EK+ Q + + +S + S+
Sbjct: 493 TAAEMLKHKFVERCKTGASAMSPKI--------EKSRQIRATMALQAQSVVAPSLEDTST 544
Query: 315 IEGNASQDAGSFTEKEPEDIDIKWDFDSLSSREYILENDI 354
+ +S++ G +P + S +R++I N +
Sbjct: 545 LGPKSSEELGITVPSKPPQNSTEAPLTSTLNRQHITGNTV 584
>YDR523c [T] KOG0201 Serine/threonine protein kinase
Length = 490
Score = 218 bits (554), Expect = 5e-56
Identities = 119/261 (45%), Positives = 167/261 (63%), Gaps = 9/261 (3%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
L+ + IGRG FG VYKA TQ++ AIKV+NL+++++++E + +EI FL+ LK +P
Sbjct: 17 LYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELK-SPL 75
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLR----PGIIEEKYIGVIMREILVALISIHR 130
IT+Y + L D +W++MEYC GGS LL+ G+ EEK + I+ E+ + L +H
Sbjct: 76 ITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEK-VSFIIHEVTLGLKYLHE 134
Query: 131 DNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI-MEGVY 189
IHRDIKAANIL+ G VKL DFGV+ + +S LKR T GTPYWMAPEV+ E
Sbjct: 135 QRKIHRDIKAANILLNEEGMVKLGDFGVSGHI-RSTLKRDTFVGTPYWMAPEVVCCEVDG 193
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALC 249
Y+ K DIWSLGIT YE+ G PP + ++ M + K KPP+L+G +S K+F+A C
Sbjct: 194 YNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQG-PFSDAAKDFVAGC 252
Query: 250 LDEDPKERPYAEELFKSKLIK 270
L + P +RP A L + +K
Sbjct: 253 LVKTPADRPSAYNLLSFEFVK 273
>SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase
Length = 471
Score = 216 bits (550), Expect = 1e-55
Identities = 125/313 (39%), Positives = 187/313 (58%), Gaps = 5/313 (1%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G FGVV+KA + + AIK ++L+ D++ DI +E+ LS+ + N+ YYG
Sbjct: 15 LGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSNCNSS-NVIQYYGC 73
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
++ LW++ME+ GGS+ LL+ G + E+ I +I+RE+L L +H N IHRDIKAA
Sbjct: 74 FVDGYTLWILMEHMDGGSVSGLLKMGRLNEQVISIILREVLYGLNYLHGQNKIHRDIKAA 133
Query: 142 NILIANN-GSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLG 200
NIL++++ G+VKL DFGVAAQLS + +R T GTP+WMAPEVI + Y DIWSLG
Sbjct: 134 NILLSSSTGNVKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVIQQ-TSYGLAADIWSLG 192
Query: 201 ITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERPYA 260
ITA E+A G PP M +R + I +S+PP+L+ +S ++F++ CLD +P R A
Sbjct: 193 ITAIEMANGIPPRATMHPMRVIFEIPQSEPPKLDD-HFSPTFRDFVSCCLDLNPNMRWSA 251
Query: 261 EELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNSSIEGNAS 320
+EL + IK GT I+ L+ + + ++Q EE + + K EGNA
Sbjct: 252 KELLQHPFIK-SAGTVKDIIPLLVQKENKLFDDSDQSVLEETINNTLKPFEEPIAEGNAD 310
Query: 321 QDAGSFTEKEPED 333
+ +F + D
Sbjct: 311 IEDWTFETVKKSD 323
>Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 487
Score = 213 bits (543), Expect = 9e-55
Identities = 121/306 (39%), Positives = 182/306 (58%), Gaps = 13/306 (4%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F E +G G +G VYKA H +T Q+ AIK + + E ++++I KEI + +P+
Sbjct: 29 VFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV---ESDLQEIIKEISIMQQC-DSPH 84
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTL--LRPGIIEEKYIGVIMREILVALISIHRDN 132
+ YYGSY +T LW++MEYC GS+ + LR + E I I++ L L +H
Sbjct: 85 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMR 144
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
IHRDIKA NIL+ G KL DFGVA QL+ +M KR T+ GTP+WMAPEVI E + Y+
Sbjct: 145 KIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IGYNC 203
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKEFIALCLD 251
DIWSLGITA E+A G PPY + +RA+ MI + PP E +S +F+ CL
Sbjct: 204 VADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 263
Query: 252 EDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYL---LFREKNEQYKHEEESHTSSK 308
+ P++R A +L + ++ KG S IL++LI + L R++++Q + +++ +S+
Sbjct: 264 KSPEQRATATQLLQHPFVRSAKGVS--ILRDLINEAMDVKLKRQESQQREVDQDDEENSE 321
Query: 309 QNPNSS 314
++ S
Sbjct: 322 EDEMDS 327
>Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 211 bits (537), Expect = 5e-54
Identities = 122/303 (40%), Positives = 179/303 (58%), Gaps = 16/303 (5%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F E +G G +G V+KA H ++ QV AIK + + E ++++I KEI + +P
Sbjct: 26 VFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQEIIKEISIMQQC-DSPY 81
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLR---PGIIEEKYIGVIMREILVALISIHRD 131
+ YYGSY +T LW++MEYC GS+ ++R +IE++ I I++ L L +H
Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDE-IATILKSTLKGLEYLHFM 140
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYD 191
IHRDIKA NIL+ G KL DFGVA QL+ +M KR T+ GTP+WMAPEVI E + Y+
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IGYN 199
Query: 192 TKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKEFIALCL 250
DIWSLGIT+ E+A G PPY + +RA+ MI + PP E +S +F+ CL
Sbjct: 200 CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 259
Query: 251 DEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQN 310
++P++R A +L + IK K S IL++LIT + + K +HEE+ ++
Sbjct: 260 VKNPEQRATATQLLQHPFIKNAKPVS--ILRDLITEAMEIKAK----RHEEQQRELEEEE 313
Query: 311 PNS 313
NS
Sbjct: 314 ENS 316
>Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 210 bits (534), Expect = 1e-53
Identities = 121/303 (39%), Positives = 179/303 (58%), Gaps = 16/303 (5%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+F E +G G +G V+KA H ++ QV AIK + + E ++++I KEI + +P
Sbjct: 26 VFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQEIIKEISIMQQC-DSPY 81
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLR---PGIIEEKYIGVIMREILVALISIHRD 131
+ YYGSY +T LW++MEYC GS+ ++R +IE++ I I++ L L +H
Sbjct: 82 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDE-IATILKSTLKGLEYLHFM 140
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYD 191
IHRDIKA NIL+ G KL DFGVA QL+ +M KR T+ GTP+WMAPEVI E + Y+
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IGYN 199
Query: 192 TKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKEFIALCL 250
DIWSLGIT+ E+A G PPY + +RA+ MI + PP E +S +F+ CL
Sbjct: 200 CVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL 259
Query: 251 DEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQN 310
++P++R A +L + IK K S IL++LIT + + K +H+E+ ++
Sbjct: 260 VKNPEQRATATQLLQHPFIKNAKPVS--ILRDLITEAMEIKAK----RHDEQQRELEEEE 313
Query: 311 PNS 313
NS
Sbjct: 314 ENS 316
>7302458 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 596
Score = 204 bits (518), Expect = 7e-52
Identities = 115/275 (41%), Positives = 161/275 (57%), Gaps = 10/275 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G VYKA H ++ + AIK++ + E ++ +I KEI + +P + YYGS
Sbjct: 48 LGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQC-DSPYVVRYYGS 103
Query: 82 YLIDTKLWVIMEYCAGGSLRTL--LRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIK 139
Y LW+ MEYC GS+ + LR + E I I+ + L L+ +H IHRDIK
Sbjct: 104 YFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIK 163
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSL 199
AANIL+ G KL DFGVA QL+ +M KR T+ GTP+WMAPEVI E + YD DIWSL
Sbjct: 164 AANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-EEIGYDCVADIWSL 222
Query: 200 GITAYEIATGNPPYCHMEAIRAMQMITKSKPPRL-EGREYSQPLKEFIALCLDEDPKERP 258
GITA E+A G PPY + +RA+ MI + PP E +S +F++ CL ++P +R
Sbjct: 223 GITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRA 282
Query: 259 YAEELFKSKLIKQEKGTSTVILKELITRYLLFREK 293
A EL + + I+ K S ILK ++ RE+
Sbjct: 283 TATELLEHEFIRNAKHRS--ILKPMLEETCAIREQ 315
>Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 545
Score = 202 bits (515), Expect = 2e-51
Identities = 117/264 (44%), Positives = 158/264 (59%), Gaps = 4/264 (1%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+ R E IG+G G VY A V T Q AIK +NL + + E I EI + K PNI
Sbjct: 270 YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKN-PNI 327
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIH 135
+Y SYL+ +LWV+MEY AGGSL ++ ++E I + RE L AL +H + VIH
Sbjct: 328 VNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIH 387
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
RDIK+ NIL+ +GSVKL DFG AQ++ KR TM GTPYWMAPEV+ Y KVD
Sbjct: 388 RDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVD 446
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKEFIALCLDEDP 254
IWSLGI A E+ G PPY + +RA+ +I + P L+ E S ++F+ CLD D
Sbjct: 447 IWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLDMDV 506
Query: 255 KERPYAEELFKSKLIKQEKGTSTV 278
++R A+EL + + +K K S++
Sbjct: 507 EKRGSAKELLQHQFLKIAKPLSSL 530
>CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 525
Score = 201 bits (510), Expect = 6e-51
Identities = 111/256 (43%), Positives = 154/256 (59%), Gaps = 8/256 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G V+KA H ++ V AIK + +D ++++I KEI + K + + YYGS
Sbjct: 69 LGEGSYGSVHKAIHRESGHVLAIKKVPVDT---DLQEIIKEISIMQQCK-SKYVVKYYGS 124
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGI--IEEKYIGVIMREILVALISIHRDNVIHRDIK 139
Y + LW++MEYC GS+ ++R + E+ I ++R+ L L +H IHRDIK
Sbjct: 125 YFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIK 184
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSL 199
A NIL+ +G KL DFGVA QL+ +M KR T+ GTP+WMAPEVI E + YDTK DIWSL
Sbjct: 185 AGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-EEIGYDTKADIWSL 243
Query: 200 GITAYEIATGNPPYCHMEAIRAMQMITKSKPPRL-EGREYSQPLKEFIALCLDEDPKERP 258
GITA E+A G PPY + +RA+ MI PP + E+S +FI CL + P+ER
Sbjct: 244 GITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERK 303
Query: 259 YAEELFKSKLIKQEKG 274
A L + IK G
Sbjct: 304 TALRLCEHTFIKNAPG 319
>CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 640
Score = 201 bits (510), Expect = 6e-51
Identities = 111/256 (43%), Positives = 154/256 (59%), Gaps = 8/256 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G V+KA H ++ V AIK + +D ++++I KEI + K + + YYGS
Sbjct: 41 LGEGSYGSVHKAIHRESGHVLAIKKVPVDT---DLQEIIKEISIMQQCK-SKYVVKYYGS 96
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGI--IEEKYIGVIMREILVALISIHRDNVIHRDIK 139
Y + LW++MEYC GS+ ++R + E+ I ++R+ L L +H IHRDIK
Sbjct: 97 YFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIK 156
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSL 199
A NIL+ +G KL DFGVA QL+ +M KR T+ GTP+WMAPEVI E + YDTK DIWSL
Sbjct: 157 AGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-EEIGYDTKADIWSL 215
Query: 200 GITAYEIATGNPPYCHMEAIRAMQMITKSKPPRL-EGREYSQPLKEFIALCLDEDPKERP 258
GITA E+A G PPY + +RA+ MI PP + E+S +FI CL + P+ER
Sbjct: 216 GITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERK 275
Query: 259 YAEELFKSKLIKQEKG 274
A L + IK G
Sbjct: 276 TALRLCEHTFIKNAPG 291
>CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 421
Score = 201 bits (510), Expect = 6e-51
Identities = 111/256 (43%), Positives = 154/256 (59%), Gaps = 8/256 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G V+KA H ++ V AIK + +D ++++I KEI + K + + YYGS
Sbjct: 41 LGEGSYGSVHKAIHRESGHVLAIKKVPVDT---DLQEIIKEISIMQQCK-SKYVVKYYGS 96
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGI--IEEKYIGVIMREILVALISIHRDNVIHRDIK 139
Y + LW++MEYC GS+ ++R + E+ I ++R+ L L +H IHRDIK
Sbjct: 97 YFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIK 156
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSL 199
A NIL+ +G KL DFGVA QL+ +M KR T+ GTP+WMAPEVI E + YDTK DIWSL
Sbjct: 157 AGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-EEIGYDTKADIWSL 215
Query: 200 GITAYEIATGNPPYCHMEAIRAMQMITKSKPPRL-EGREYSQPLKEFIALCLDEDPKERP 258
GITA E+A G PPY + +RA+ MI PP + E+S +FI CL + P+ER
Sbjct: 216 GITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERK 275
Query: 259 YAEELFKSKLIKQEKG 274
A L + IK G
Sbjct: 276 TALRLCEHTFIKNAPG 291
>CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 523
Score = 201 bits (510), Expect = 6e-51
Identities = 111/256 (43%), Positives = 154/256 (59%), Gaps = 8/256 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G V+KA H ++ V AIK + +D ++++I KEI + K + + YYGS
Sbjct: 69 LGEGSYGSVHKAIHRESGHVLAIKKVPVDT---DLQEIIKEISIMQQCK-SKYVVKYYGS 124
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGI--IEEKYIGVIMREILVALISIHRDNVIHRDIK 139
Y + LW++MEYC GS+ ++R + E+ I ++R+ L L +H IHRDIK
Sbjct: 125 YFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIK 184
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSL 199
A NIL+ +G KL DFGVA QL+ +M KR T+ GTP+WMAPEVI E + YDTK DIWSL
Sbjct: 185 AGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-EEIGYDTKADIWSL 243
Query: 200 GITAYEIATGNPPYCHMEAIRAMQMITKSKPPRL-EGREYSQPLKEFIALCLDEDPKERP 258
GITA E+A G PPY + +RA+ MI PP + E+S +FI CL + P+ER
Sbjct: 244 GITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERK 303
Query: 259 YAEELFKSKLIKQEKG 274
A L + IK G
Sbjct: 304 TALRLCEHTFIKNAPG 319
>Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 544
Score = 200 bits (508), Expect = 1e-50
Identities = 115/264 (43%), Positives = 155/264 (58%), Gaps = 4/264 (1%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+ R E IG+G G VY A + T Q AIK +NL + + E I EI + K PNI
Sbjct: 268 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQ-QPKKELIINEILVMRENKN-PNI 325
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIH 135
+Y SYL+ +LWV+MEY AGGSL ++ ++E I + RE L AL +H + VIH
Sbjct: 326 VNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIH 385
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
RDIK+ NIL+ +GSVKL DFG AQ++ KR TM GTPYWMAPEV+ Y KVD
Sbjct: 386 RDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKVD 444
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKEFIALCLDEDP 254
IWSLGI A E+ G PPY + +RA+ +I + P L+ E S ++F+ CL+ D
Sbjct: 445 IWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDV 504
Query: 255 KERPYAEELFKSKLIKQEKGTSTV 278
R A+EL + +K K S++
Sbjct: 505 DRRGSAKELLQHPFLKLAKPLSSL 528
>Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 894
Score = 196 bits (499), Expect = 1e-49
Identities = 111/270 (41%), Positives = 166/270 (61%), Gaps = 8/270 (2%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
F+ + IG G +G VYKA +V T ++ AIKV+ L+ ED +++EI + K PNI
Sbjct: 16 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-VQQEIIMMKDCKH-PNI 73
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIHRDNVI 134
Y+GSYL KLW+ ME+C GGSL+ + G + E I + RE L L +H +
Sbjct: 74 VAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKM 133
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEV--IMEGVYYDT 192
HRDIK ANIL+ +NG VKL DFGV+AQ++ ++ KR++ GTPYWMAPEV + Y+
Sbjct: 134 HRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQ 193
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGR-EYSQPLKEFIALC 249
D+W++GITA E+A PP + +RA+ ++TKS +PP+L+ + ++S F+ +
Sbjct: 194 LCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMA 253
Query: 250 LDEDPKERPYAEELFKSKLIKQEKGTSTVI 279
L ++PK+RP AE+L + + Q S I
Sbjct: 254 LTKNPKKRPTAEKLLQHPFVTQHLTRSLAI 283
>Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 196 bits (498), Expect = 2e-49
Identities = 108/279 (38%), Positives = 159/279 (56%), Gaps = 17/279 (6%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
E IG+G +G V+K + K Q A+K+L D D E+I E L +L PN+ +Y
Sbjct: 25 ETIGKGTYGKVFKVLNKKNGQKAAVKIL--DPIHDIDEEIEAEYNILKALSDHPNVVRFY 82
Query: 80 GSY-----LIDTKLWVIMEYCAGGSLRTLLRPGI-----IEEKYIGVIMREILVALISIH 129
G Y + KLW+++E C+GGS+ L++ + + E I I+ E L+ L +H
Sbjct: 83 GIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLH 142
Query: 130 RDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI----M 185
+ IHRD+K NIL+ G VKL DFGV+AQL+ + +R T GTP+WMAPEVI
Sbjct: 143 NNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQ 202
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKE 244
YD + D WSLGITA E+ G+PP + +RA+ I ++ PP+L E +S +
Sbjct: 203 LDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFND 262
Query: 245 FIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVILKEL 283
FI+ CL +D ++RP EL + K I Q +G ++ K+L
Sbjct: 263 FISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQL 301
>Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 196 bits (498), Expect = 2e-49
Identities = 108/279 (38%), Positives = 159/279 (56%), Gaps = 17/279 (6%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
E IG+G +G V+K + K Q A+K+L D D E+I E L +L PN+ +Y
Sbjct: 25 ETIGKGTYGKVFKVLNKKNGQKAAVKIL--DPIHDIDEEIEAEYNILKALSDHPNVVRFY 82
Query: 80 GSY-----LIDTKLWVIMEYCAGGSLRTLLRPGI-----IEEKYIGVIMREILVALISIH 129
G Y + KLW+++E C+GGS+ L++ + + E I I+ E L+ L +H
Sbjct: 83 GIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLH 142
Query: 130 RDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI----M 185
+ IHRD+K NIL+ G VKL DFGV+AQL+ + +R T GTP+WMAPEVI
Sbjct: 143 NNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQ 202
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKE 244
YD + D WSLGITA E+ G+PP + +RA+ I ++ PP+L E +S +
Sbjct: 203 LDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFND 262
Query: 245 FIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVILKEL 283
FI+ CL +D ++RP EL + K I Q +G ++ K+L
Sbjct: 263 FISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQL 301
>Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 820
Score = 196 bits (497), Expect = 2e-49
Identities = 104/263 (39%), Positives = 161/263 (60%), Gaps = 8/263 (3%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
F+ + +G G +G VYKA T ++ A+K++ LD D++ +++EI L + PN+
Sbjct: 16 FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD-PGDDISSLQQEITILRECRH-PNV 73
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNVI 134
Y GSYL + +LW+ ME+C GGSL+ + G +EE+ I + RE L L +H I
Sbjct: 74 VAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKI 133
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEV--IMEGVYYDT 192
HRDIK AN+L+ G VKL DFGV+ +L+ S+ KR++ GTPYWMAPEV + Y+
Sbjct: 134 HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNE 193
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGR-EYSQPLKEFIALC 249
D+W+LGITA E+ PP H+ +RA+ +++KS +PP+L + ++Q F+ L
Sbjct: 194 LCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLA 253
Query: 250 LDEDPKERPYAEELFKSKLIKQE 272
L ++PK+RP AE+L + Q+
Sbjct: 254 LTKNPKKRPTAEKLLQHPFTTQQ 276
>HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 819
Score = 195 bits (495), Expect = 3e-49
Identities = 104/263 (39%), Positives = 161/263 (60%), Gaps = 8/263 (3%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
F+ + +G G +G VYKA T ++ A+K++ LD D++ +++EI L + PN+
Sbjct: 15 FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD-PGDDISSLQQEITILRECRH-PNV 72
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNVI 134
Y GSYL + +LW+ ME+C GGSL+ + G +EE+ I + RE L L +H I
Sbjct: 73 VAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCRERLKGLHHLHSQGKI 132
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEV--IMEGVYYDT 192
HRDIK AN+L+ G VKL DFGV+ +L+ S+ KR++ GTPYWMAPEV + Y+
Sbjct: 133 HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNE 192
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGR-EYSQPLKEFIALC 249
D+W+LGITA E+ PP H+ +RA+ +++KS +PP+L + ++Q F+ L
Sbjct: 193 LCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLA 252
Query: 250 LDEDPKERPYAEELFKSKLIKQE 272
L ++PK+RP AE+L + Q+
Sbjct: 253 LTKNPKKRPTAEKLLQHPFTTQQ 275
>7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 1218
Score = 194 bits (493), Expect = 6e-49
Identities = 128/363 (35%), Positives = 199/363 (54%), Gaps = 29/363 (7%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IG G +G VYKA +++ ++ AIKV+ L+ ++D ++ I++EI + + PNI YYGS
Sbjct: 32 IGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDD-IQIIQQEIIMMRDCRH-PNIIAYYGS 89
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIHRDNVIHRDIKA 140
YL KLW+ ME+C GGSL+ + + G + E I + RE L L +H +HRDIK
Sbjct: 90 YLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKG 149
Query: 141 ANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEV--IMEGVYYDTKVDIWS 198
ANIL+ G VKL DFGV+AQ++ ++ KR++ GTPYWMAPEV + Y+ DIW+
Sbjct: 150 ANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWA 209
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGRE-YSQPLKEFIALCLDEDPK 255
GITA E+A PP + +RA+ +++KS KPP L ++ +S FI L ++PK
Sbjct: 210 CGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPK 269
Query: 256 ERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKH----EEESHTSSKQNP 311
+RP AE L + ++ E S + KEL+ +Y + N Q+ + +EES Q
Sbjct: 270 KRPTAERLLQHPFVQCE--MSLRVAKELLQKY---QSPNPQFYYYLDGDEESVAGVPQRI 324
Query: 312 NSSIEGNAS-QDAGSFTEKEPEDIDIKWDFDSLSSREYILENDINVEAIPEEADWIKYSP 370
S + + A + T K + W+ E + E +P + ++Y
Sbjct: 325 ASKMTSRTNGVPAQNHTLKTGMTTNSTWN-----------ERSSSPETLPSDMSLLQYID 373
Query: 371 QEV 373
+E+
Sbjct: 374 EEL 376
>Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 194 bits (492), Expect = 8e-49
Identities = 105/293 (35%), Positives = 172/293 (57%), Gaps = 24/293 (8%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
++ +E+IG G VV A Q+ AIK +NL+ + ++++ KEIQ +S PN+
Sbjct: 65 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSH-PNV 123
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLR---------PGIIEEKYIGVIMREILVALI 126
YY S+++ +LW++M+ +GGS+ +++ G++EE I I++E+L L
Sbjct: 124 VTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLD 183
Query: 127 SIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQS-----MLKRQTMAGTPYWMAP 181
+HR+ IHRD+KA NIL+ +GSV++ DFGV+A L+ R+T GTP WMAP
Sbjct: 184 YLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAP 243
Query: 182 EVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEG------ 235
EV+ + YD K D+WS GITA E+ATG PY ++ + + ++ PP LE
Sbjct: 244 EVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKE 303
Query: 236 --REYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITR 286
++Y + ++ ++LCL +DP +RP A EL K K ++ K ++++L+TR
Sbjct: 304 MMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNRE-YLIEKLLTR 355
>At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 561
Score = 193 bits (491), Expect = 1e-48
Identities = 114/310 (36%), Positives = 172/310 (54%), Gaps = 20/310 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+K E IG G V++A + V AIKVL+L+ ++++ IR+E+Q +S + PN+
Sbjct: 16 YKLYEEIGDGVSATVHRALCIPLNVVVAIKVLDLEKCNNDLDGIRREVQTMSLINH-PNV 74
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLR---PGIIEEKYIGVIMREILVALISIHRDN 132
+ S+ +LWV+M Y AGGS +++ P EE I ++RE L AL+ +H
Sbjct: 75 LQAHCSFTTGHQLWVVMPYMAGGSCLHIIKSSYPDGFEEPVIATLLRETLKALVYLHAHG 134
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQS---MLKRQTMAGTPYWMAPEVIMEGVY 189
IHRD+KA NIL+ +NG+VKL DFGV+A + + R T GTP WMAPEV+ +
Sbjct: 135 HIHRDVKAGNILLDSNGAVKLADFGVSACMFDTGDRQRSRNTFVGTPCWMAPEVMQQLHG 194
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE---GREYSQPLKEFI 246
YD K D+WS GITA E+A G+ P+ ++ + M ++ PP L+ + +S+ KE +
Sbjct: 195 YDFKADVWSFGITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERDKRFSKAFKEMV 254
Query: 247 ALCLDEDPKERPYAEELFKSKLIKQEKGTSTVI------LKELITRYLLFREKNE----Q 296
CL +DPK+RP +E+L K K + ++ L L RY + K Q
Sbjct: 255 GTCLVKDPKKRPTSEKLLKHPFFKHARPADYLVKTILNGLPPLGDRYRQIKSKEADLLMQ 314
Query: 297 YKHEEESHTS 306
K E E+H S
Sbjct: 315 NKSEYEAHLS 324
>Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 525
Score = 193 bits (490), Expect = 1e-48
Identities = 112/265 (42%), Positives = 157/265 (58%), Gaps = 5/265 (1%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+ R E IG+G G V+ A V Q AIK +NL + + E I EI + LK PNI
Sbjct: 249 YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQK-QPKKELIINEILVMKELKN-PNI 306
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLL-RPGIIEEKYIGVIMREILVALISIHRDNVI 134
++ SYL+ +L+V+MEY AGGSL ++ ++E I + RE L AL +H + VI
Sbjct: 307 VNFLDSYLVGDELFVVMEYLAGGSLTDVVTETACMDEAQIAAVCRECLQALEFLHANQVI 366
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIK+ N+L+ GSVKL DFG AQ++ KR TM GTPYWMAPEV+ Y KV
Sbjct: 367 HRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGPKV 425
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPL-KEFIALCLDED 253
DIWSLGI A E+ G PPY + +RA+ +I + P L+ E P+ ++F+ CL+ D
Sbjct: 426 DIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMD 485
Query: 254 PKERPYAEELFKSKLIKQEKGTSTV 278
++R A+EL + +K K S++
Sbjct: 486 VEKRGSAKELLQHPFLKLAKPLSSL 510
>Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 527
Score = 192 bits (488), Expect = 2e-48
Identities = 102/280 (36%), Positives = 166/280 (58%), Gaps = 23/280 (8%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
++ +E+IG G VV A+ ++ AIK +NL+ + ++++ KEIQ +S PNI
Sbjct: 17 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHH-PNI 75
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLR---------PGIIEEKYIGVIMREILVALI 126
YY S+++ +LW++M+ +GGS+ +++ G+++E I I+RE+L L
Sbjct: 76 VSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLE 135
Query: 127 SIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQS-----MLKRQTMAGTPYWMAP 181
+H++ IHRD+KA NIL+ +GSV++ DFGV+A L+ R+T GTP WMAP
Sbjct: 136 YLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAP 195
Query: 182 EVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEG------ 235
EV+ + YD K DIWS GITA E+ATG PY ++ + + ++ PP LE
Sbjct: 196 EVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKE 255
Query: 236 --REYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEK 273
++Y + ++ I+LCL +DP++RP A EL + K ++ K
Sbjct: 256 MLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 295
>Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 846
Score = 192 bits (488), Expect = 2e-48
Identities = 115/314 (36%), Positives = 179/314 (56%), Gaps = 17/314 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G VYKA +V T ++ A+K++ L+ D+ I++EI + K NI Y+GS
Sbjct: 26 VGSGTYGDVYKARNVHTGELAAVKIIKLE-PGDDFSLIQQEIFMVKECKHC-NIVAYFGS 83
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIHRDNVIHRDIKA 140
YL KLW+ MEYC GGSL+ + G + E I + RE L L +H +HRDIK
Sbjct: 84 YLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKG 143
Query: 141 ANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEV--IMEGVYYDTKVDIWS 198
ANIL+ ++G VKL DFGVAA+++ ++ KR++ GTPYWMAPEV + + Y+ DIW+
Sbjct: 144 ANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWA 203
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGR-EYSQPLKEFIALCLDEDPK 255
+GITA E+ PP + +RA+ +++KS +PP+L+ + ++S F+ + L ++PK
Sbjct: 204 VGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPK 263
Query: 256 ERPYAEELFKSKLIKQEKGTSTVILKELITR--------YLLFREKNEQYKHEEESHTSS 307
+RP AE L + Q G S + EL+ + + + ++ H HT
Sbjct: 264 KRPTAERLLTHTFVAQ-PGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIR 322
Query: 308 KQNPNSSIEGNASQ 321
N N+ E AS+
Sbjct: 323 STNRNARAERTASE 336
>At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 710
Score = 192 bits (488), Expect = 2e-48
Identities = 124/359 (34%), Positives = 190/359 (52%), Gaps = 29/359 (8%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+K E IG G VVY+A ++ T +V AIK L+LD ++DIR+E Q +S + PN+
Sbjct: 33 YKLMEEIGHGASAVVYRAIYLPTNEVVAIKCLDLDRCNSNLDDIRRESQTMSLIDH-PNV 91
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI---IEEKYIGVIMREILVALISIHRDN 132
+ S+ +D LWV+M + A GS L++ EE I +++E L AL +HR
Sbjct: 92 IKSFCSFSVDHSLWVVMPFMAQGSCLHLMKTAYSDGFEESAICCVLKETLKALDYLHRQG 151
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQS---MLKRQTMAGTPYWMAPEVIMEGVY 189
IHRD+KA NIL+ +NG +KL DFGV+A L + R T GTP WMAPEV+ G
Sbjct: 152 HIHRDVKAGNILLDDNGEIKLGDFGVSACLFDNGDRQRARNTFVGTPCWMAPEVLQPGNG 211
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE---GREYS------- 239
Y++K DIWS GITA E+A G+ P+ ++ + M ++ PP L+ +++S
Sbjct: 212 YNSKADIWSFGITALELAHGHAPFSKYPPMKVLLMTIQNAPPGLDYDRDKKFSKRTFSCA 271
Query: 240 QPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVI------LKELITRYLLFREK 293
Q KE +A+CL +D +RP AE+L K K K + L L TR ++K
Sbjct: 272 QSFKEMVAMCLVKDQTKRPTAEKLLKHSCFKHTKPPEQTVKILFSDLPPLWTRVKSLQDK 331
Query: 294 NEQYKHEEESHTSSKQNPNSSIEGNASQDAGSFTEKEPEDIDIKWDFDSLSSREYILEN 352
+ Q + T+ ++ + S E A +F + D+K ++ RE + ++
Sbjct: 332 DAQQLALKRMATADEEAISQS-EYQRGVSAWNFDVR-----DLKTQASLVNDREQVFDS 384
>YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 939
Score = 190 bits (483), Expect = 8e-48
Identities = 115/304 (37%), Positives = 168/304 (54%), Gaps = 6/304 (1%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IG+G G VY A+ + T AIK +NL+ + + E I EI + K PNI ++ S
Sbjct: 626 IGQGASGGVYTAYEIGTNVSVAIKQMNLEK-QPKKELIINEILVMKGSKH-PNIVNFIDS 683
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
Y++ LWVIMEY GGSL ++ I+ E IG + RE L L +H V+HRDIK+
Sbjct: 684 YVLKGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSD 743
Query: 142 NILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGI 201
NIL++ G +KL DFG AQ+++ LKR TM GTPYWMAPEV+ Y KVDIWSLGI
Sbjct: 744 NILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSR-KEYGPKVDIWSLGI 802
Query: 202 TAYEIATGNPPYCHMEAIRAMQMITKSKPPRL-EGREYSQPLKEFIALCLDEDPKERPYA 260
E+ G PPY + +RA+ +I + P+L E S LK+F+ CL +P++R A
Sbjct: 803 MIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASA 862
Query: 261 EELFKSKLIKQ--EKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNSSIEGN 318
EL + I + E +S L +L + + +++++ N+ + N
Sbjct: 863 TELLHDEYITEIAEANSSLAPLVKLARLKKVAENMDADEDNDDDNDNEHINKTNNCDDNN 922
Query: 319 ASQD 322
S++
Sbjct: 923 DSKE 926
>7298926 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 704
Score = 190 bits (483), Expect = 8e-48
Identities = 108/256 (42%), Positives = 148/256 (57%), Gaps = 4/256 (1%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+ + E IG+G G VY A T AIK +NL + + E I EI + K PN+
Sbjct: 430 YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQ-QPKKELIINEILVMRENKH-PNV 487
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIH 135
+Y SYL+ +LWV+MEY GGSL ++ ++E I + RE+L AL +H + VIH
Sbjct: 488 VNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIH 547
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
RDIK+ NIL+ +GSVKL DFG AQ+S KR TM GTPYWMAPEV+ Y KVD
Sbjct: 548 RDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTR-KQYGPKVD 606
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMI-TKSKPPRLEGREYSQPLKEFIALCLDEDP 254
+WSLGI A E+ G PPY + ++A+ +I T KP E + S ++F+ CL+ +
Sbjct: 607 LWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEV 666
Query: 255 KERPYAEELFKSKLIK 270
R A +L K +K
Sbjct: 667 DRRASALDLLKHPFLK 682
>7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1726
Score = 190 bits (482), Expect = 1e-47
Identities = 107/275 (38%), Positives = 160/275 (57%), Gaps = 15/275 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G FG VYKA H + ++ A K+ L++ E+ + D EI LS +K PNI Y +
Sbjct: 43 LGDGAFGKVYKAQHKEQKRFAAAKMCQLED-EENLSDHMVEIDILSEIKH-PNIVELYEA 100
Query: 82 YLIDTKLWVIMEYCAGGSLRTLL----RPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
+ ID KLW+++EYC GG+L +++ +P + E I + + + L +HR+ VIHRD
Sbjct: 101 FSIDDKLWMLIEYCDGGALDSIMVELEKP--LTEPQIAYVCKHMTEGLTFLHRNKVIHRD 158
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY----YDTK 193
+KA N+L+ G VKL DFGV+A+ +M K T GTPYWMAPE+++ + YD K
Sbjct: 159 LKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHK 218
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE-GREYSQPLKEFIALCLDE 252
VDIWSLGIT E+A PP M +R + I KS+PP+LE +S+ +F+ L +
Sbjct: 219 VDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVK 278
Query: 253 DPKERPYAEELFKSKLIKQEKGTSTVILKELITRY 287
DP+ RP + L + I + + K+L+ Y
Sbjct: 279 DPQVRPTTDVLMQHAFINRNLDAKPI--KDLLLEY 311
>Hs19923464 [T] KOG0577 Serine/threonine protein kinase
Length = 898
Score = 189 bits (479), Expect = 2e-47
Identities = 117/330 (35%), Positives = 173/330 (51%), Gaps = 12/330 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTPNITHYY 79
IG G FG VY A + T +V AIK ++ T ++ +DI KE++FL LK PN Y
Sbjct: 30 IGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKH-PNTIEYK 88
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTL-LRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G YL + W++MEYC G + L + ++E I I L L +H +IHRDI
Sbjct: 89 GCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDI 148
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVYYDTKVDI 196
KA NIL+ G VKL DFG A+ S + + GTPYWMAPEVI M+ YD KVDI
Sbjct: 149 KAGNILLTEPGQVKLADFGSASMASPA----NSFVGTPYWMAPEVILAMDEGQYDGKVDI 204
Query: 197 WSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKE 256
WSLGIT E+A PP +M A+ A+ I ++ P L+ E++ + F+ CL + P+E
Sbjct: 205 WSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQE 264
Query: 257 RPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNP--NSS 314
RP + EL + +++++ +I T+ + N QY+ ++ +N N S
Sbjct: 265 RPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNES 324
Query: 315 IEGNASQDAGSFTEKEPEDIDIKWDFDSLS 344
E + G+ +E + + S+S
Sbjct: 325 QEDEEDSEHGTSLNREMDSLGSNHSIPSMS 354
>CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 829
Score = 186 bits (473), Expect = 1e-46
Identities = 102/251 (40%), Positives = 154/251 (60%), Gaps = 8/251 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G VYKA +++ + A+KV+ L+ D I++EI + PNI Y+GS
Sbjct: 21 VGSGTYGEVYKARDIRSDSLAAVKVVKLE-AGDNFAVIQQEIMVIRECSH-PNIIAYFGS 78
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIHRDNVIHRDIKA 140
Y+ +LW++MEYC GGSL+ + G + E I + RE L L +H IHRDIK
Sbjct: 79 YIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKIHRDIKG 138
Query: 141 ANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEV--IMEGVYYDTKVDIWS 198
ANIL++++G VKL DFGVAAQ++ ++ KR++ GTPYWMAPEV + + Y + D+W+
Sbjct: 139 ANILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMQCDVWA 198
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGREYSQPL-KEFIALCLDEDPK 255
GITA E+ PP + ++ + ++TKS KPP L+ + PL +F+ CL ++PK
Sbjct: 199 TGITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWTPLFHDFVRQCLTKNPK 258
Query: 256 ERPYAEELFKS 266
+RP E+L S
Sbjct: 259 KRPSPEKLLTS 269
>At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 693
Score = 185 bits (470), Expect = 3e-46
Identities = 108/282 (38%), Positives = 160/282 (56%), Gaps = 17/282 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+K E +G G VV++A ++ T +V AIK L+LD ++DIR+E Q ++ + PN+
Sbjct: 27 YKLMEEVGYGASAVVHRAIYLPTNEVVAIKSLDLDRCNSNLDDIRREAQTMTLIDH-PNV 85
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLR---PGIIEEKYIGVIMREILVALISIHRDN 132
+ S+ +D LWV+M + A GS L++ P EE I +++E L AL +HR
Sbjct: 86 IKSFCSFAVDHHLWVVMPFMAQGSCLHLMKAAYPDGFEEAAICSMLKETLKALDYLHRQG 145
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQS---MLKRQTMAGTPYWMAPEVIMEGVY 189
IHRD+KA NIL+ + G +KL DFGV+A L + R T GTP WMAPEV+ G
Sbjct: 146 HIHRDVKAGNILLDDTGEIKLGDFGVSACLFDNGDRQRARNTFVGTPCWMAPEVLQPGSG 205
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE---GREYS------- 239
Y++K DIWS GITA E+A G+ P+ ++ + M ++ PP L+ +++S
Sbjct: 206 YNSKADIWSFGITALELAHGHAPFSKYPPMKVLLMTIQNAPPGLDYDRDKKFSKKMSSCA 265
Query: 240 QPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVILK 281
Q KE +ALCL +D +RP AE+L K K K + K
Sbjct: 266 QSFKELVALCLVKDQTKRPTAEKLLKHSFFKNVKPPEICVKK 307
>CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 572
Score = 184 bits (467), Expect = 6e-46
Identities = 108/259 (41%), Positives = 150/259 (57%), Gaps = 4/259 (1%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+++ + IG G G VY A + T+ AIK +NL + + + E I EI + K NI
Sbjct: 295 YRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKD-QPKKELIINEILVMRENKHA-NI 352
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIH 135
+Y SYL+ +LWV+MEY AGGSL ++ +E+ I + RE+L AL +H +VIH
Sbjct: 353 VNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIH 412
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
RDIK+ NIL+ +GSVKL DFG AQLS KR TM GTPYWMAPEV+ Y KVD
Sbjct: 413 RDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTR-KQYGPKVD 471
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPL-KEFIALCLDEDP 254
+WSLGI A E+ G PPY + +RA+ +I + P GR+ L K+F+ L+
Sbjct: 472 VWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQV 531
Query: 255 KERPYAEELFKSKLIKQEK 273
+ R A +L ++ K
Sbjct: 532 ENRWSASQLLTHPFLRCAK 550
>At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 487
Score = 184 bits (467), Expect = 6e-46
Identities = 117/330 (35%), Positives = 171/330 (51%), Gaps = 35/330 (10%)
Query: 22 IGRGKFGVVYKAFHVK-TQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
IG G VYKA + V AIK ++LD + + + +R+E + +S L PNI + Y
Sbjct: 21 IGVGVSASVYKAICIPMNSMVVAIKAIDLDQSRADFDSLRRETKTMSLLSH-PNILNAYC 79
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLLR---PGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
S+ +D LWV+M + + GSL +++ P + E I V ++E L A+ +H +HRD
Sbjct: 80 SFTVDRCLWVVMPFMSCGSLHSIVSSSFPSGLPENCISVFLKETLNAISYLHDQGHLHRD 139
Query: 138 IKAANILIANNGSVKLCDFGVAAQL----------SQSMLKRQTMAGTPYWMAPEVIMEG 187
IKA NIL+ ++GSVKL DFGV+A + + S L+ +AGTPYWMAPEV+
Sbjct: 140 IKAGNILVDSDGSVKLADFGVSASIYEPVTSSSGTTSSSLRLTDIAGTPYWMAPEVVHSH 199
Query: 188 VYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQM------------ITKSKPPRLEG 235
Y K DIWS GITA E+A G PP H+ ++++ M I S +
Sbjct: 200 TGYGFKADIWSFGITALELAHGRPPLSHLPPLKSLLMKITKRFHFSDYEINTSGSSKKGN 259
Query: 236 REYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV---ILKELITRYLLFRE 292
+++S+ +E + LCL++DP +RP AE+L K K KG V +L L +F E
Sbjct: 260 KKFSKAFREMVGLCLEQDPTKRPSAEKLLKHPFFKNCKGLDFVVKNVLHSLSNAEQMFME 319
Query: 293 KNEQYK-----HEEESHTSSKQNPNSSIEG 317
K EEE + N I G
Sbjct: 320 SQILIKSVGDDDEEEEEEDEEIVKNRRISG 349
>Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 968
Score = 183 bits (465), Expect = 1e-45
Identities = 115/326 (35%), Positives = 180/326 (54%), Gaps = 21/326 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G FG VYKA + +T + A KV+ +E+E+ED EI+ L++ P I G+
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIET-KSEEELEDYIVEIEILATCDH-PYIVKLLGA 99
Query: 82 YLIDTKLWVIMEYCAGGSLRTL---LRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
Y D KLW+++E+C GG++ + L G+ E + I V+ R++L AL +H +IHRD+
Sbjct: 100 YYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ-IQVVCRQMLEALNFLHSKRIIHRDL 158
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI----MEGVYYDTKV 194
KA N+L+ G ++L DFGV+A+ +++ KR + GTPYWMAPEV+ M+ YD K
Sbjct: 159 KAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKA 218
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPR-LEGREYSQPLKEFIALCLDED 253
DIWSLGIT E+A PP+ + +R + I KS PP L ++S ++F+ + LD++
Sbjct: 219 DIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKN 278
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVILKELITRYLL--------FREKNEQYKHEEESHT 305
P+ RP A +L + + TS L+EL+ R++ E+ + + T
Sbjct: 279 PETRPSAAQLLEHPFVSSI--TSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAAST 336
Query: 306 SSKQNPNSSIEGNASQDAGSFTEKEP 331
NSS S +A E+ P
Sbjct: 337 LENHTQNSSEVSPPSLNADKPLEESP 362
>Hs7706401 [T] KOG0577 Serine/threonine protein kinase
Length = 1235
Score = 182 bits (461), Expect = 3e-45
Identities = 105/277 (37%), Positives = 159/277 (56%), Gaps = 12/277 (4%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTE--DEVEDIRKEIQFLSSLKQT 72
LF IG G FG VY A V+ +V AIK ++ + ++ +DI KE++FL L+
Sbjct: 27 LFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH- 85
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSLRTL-LRPGIIEEKYIGVIMREILVALISIHRD 131
PN Y G YL + W++MEYC G + L + ++E I + L L +H
Sbjct: 86 PNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH 145
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVY 189
N+IHRD+KA NIL++ G VKL DFG A+ ++ + + GTPYWMAPEVI M+
Sbjct: 146 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMDEGQ 201
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALC 249
YD KVD+WSLGIT E+A PP +M A+ A+ I +++ P L+ +S+ + F+ C
Sbjct: 202 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSC 261
Query: 250 LDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITR 286
L + P++RP +E L K + + +E+ ++ +LI R
Sbjct: 262 LQKIPQDRPTSEVLLKHRFVLRER--PPTVIMDLIQR 296
>Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 833
Score = 182 bits (461), Expect = 3e-45
Identities = 102/256 (39%), Positives = 155/256 (59%), Gaps = 8/256 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G V+KA + + A+K++ ++ +D+V ++KEI L + + NI Y+GS
Sbjct: 23 LGGGTYGEVFKARDKVSGDLVALKMVKME-PDDDVSTLQKEILILKTCRHA-NIVAYHGS 80
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIHRDNVIHRDIKA 140
YL KLW+ ME+C GSL+ + + G + E I + RE+L L +H IHRDIK
Sbjct: 81 YLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKG 140
Query: 141 ANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY--YDTKVDIWS 198
ANILI + G V+L DFG++AQ+ ++ +R + GTPYWMAPEV + Y+ DIWS
Sbjct: 141 ANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWS 200
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRL-EGREYSQPLKEFIALCLDEDPK 255
LGITA E+A PP + +R + ++TKS +PPRL E ++S FI + L + PK
Sbjct: 201 LGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPK 260
Query: 256 ERPYAEELFKSKLIKQ 271
+RP A ++ +L+ Q
Sbjct: 261 KRPSATKMLSHQLVSQ 276
>Hs4759208 [T] KOG0577 Serine/threonine protein kinase
Length = 1049
Score = 182 bits (461), Expect = 3e-45
Identities = 105/277 (37%), Positives = 159/277 (56%), Gaps = 12/277 (4%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTE--DEVEDIRKEIQFLSSLKQT 72
LF IG G FG VY A V+ +V AIK ++ + ++ +DI KE++FL L+
Sbjct: 27 LFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH- 85
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSLRTL-LRPGIIEEKYIGVIMREILVALISIHRD 131
PN Y G YL + W++MEYC G + L + ++E I + L L +H
Sbjct: 86 PNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH 145
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVY 189
N+IHRD+KA NIL++ G VKL DFG A+ ++ + + GTPYWMAPEVI M+
Sbjct: 146 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMDEGQ 201
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALC 249
YD KVD+WSLGIT E+A PP +M A+ A+ I +++ P L+ +S+ + F+ C
Sbjct: 202 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSC 261
Query: 250 LDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITR 286
L + P++RP +E L K + + +E+ ++ +LI R
Sbjct: 262 LQKIPQDRPTSEVLLKHRFVLRER--PPTVIMDLIQR 296
>SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 658
Score = 180 bits (457), Expect = 9e-45
Identities = 102/266 (38%), Positives = 151/266 (56%), Gaps = 4/266 (1%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
L++ IG+G G VY A V T AIK +N+ N + + E I EI + S N
Sbjct: 385 LYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNI-NQQPKKEFIVNEILVMKS-HHHKN 442
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
I ++ ++ ++LW++MEY GGSL ++ + E I I +E L L +H + ++
Sbjct: 443 IVNFIDTFFYKSELWMVMEYMRGGSLTEVVTNNTLSEGQIAAICKETLEGLQHLHENGIV 502
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIK+ NIL++ G +KL DFG AQ+ +M KR TM GTPYWMAPEV+ Y KV
Sbjct: 503 HRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTR-KEYGFKV 561
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKEFIALCLDED 253
D+WSLGI A E+ G PPY + +RA+ +I P++ E S +F++ L +
Sbjct: 562 DVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVN 621
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVI 279
PK+RP + EL + +KQ S++I
Sbjct: 622 PKQRPSSGELLRHPFLKQAVPVSSLI 647
>CE01405 [T] KOG0577 Serine/threonine protein kinase
Length = 982
Score = 180 bits (457), Expect = 9e-45
Identities = 126/339 (37%), Positives = 181/339 (53%), Gaps = 24/339 (7%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTE--DEVEDIRKEIQFLSSLKQTPNITHYY 79
IG G FG VY A+ K +Q AIK +N + ++ DI KE+ FL+++ P+I Y
Sbjct: 36 IGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVVH-PHIVDYK 94
Query: 80 GSYLIDTKLWVIMEYCAGGS--LRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
+L DT W++MEYC G + + +LR G+ E + I I + L AL +H IHRD
Sbjct: 95 ACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVE-IAAICSQTLDALRYLHSLKRIHRD 153
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVYYDTKVD 195
IKA NIL++++ VKL DFG A+ + + QT GTP++MAPEVI M+ +Y + D
Sbjct: 154 IKAGNILLSDHAIVKLADFGSASLVDPA----QTFIGTPFFMAPEVILAMDEGHYTDRAD 209
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRL------EGREYSQPLKEFIALC 249
IWSLGIT E+A PP M A+ A+ I ++ PP L E E+S +FI C
Sbjct: 210 IWSLGITCIELAERRPPLFSMNAMSALYHIAQNDPPTLSPIDTSEQPEWSLEFVQFIDKC 269
Query: 250 LDEDPKERPYAEELFKSKLIKQEKGTSTVILKELI--TRYLLFREKNEQYKHEEESHTSS 307
L + +ER AEE F+ I++ + + T+ +ELI T+ ++ N QYK +
Sbjct: 270 LRKPAEERMSAEECFRHPFIQRSRPSDTI--QELIQRTKNMVLELDNFQYKKMRKLMYLD 327
Query: 308 KQNPNSSIEGNASQDAGSFTEKEPEDIDIKWDFDSLSSR 346
+ EGN + D F E I DS SSR
Sbjct: 328 ETEGKEGSEGNGASDDLDFHGNEANSIGRAG--DSASSR 364
>Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 357
Score = 180 bits (456), Expect = 1e-44
Identities = 105/279 (37%), Positives = 154/279 (54%), Gaps = 17/279 (6%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
E IG+G +G VYK + + + A+K+L D D E+I E L L PN+ +Y
Sbjct: 31 ETIGKGTYGKVYKVTNKRDGSLAAVKIL--DPVSDMDEEIEAEYNILQFLPNHPNVVKFY 88
Query: 80 GSYL-----IDTKLWVIMEYCAGGSL----RTLLRPGI-IEEKYIGVIMREILVALISIH 129
G + + +LW+++E C GGS+ + LLR G ++E I I+ L+ L +H
Sbjct: 89 GMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLH 148
Query: 130 RDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI-MEGV 188
+ +IHRD+K NIL+ G VKL DFGV+AQL+ + L+R T GTP+WMAPEVI E
Sbjct: 149 NNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQ 208
Query: 189 Y---YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPR-LEGREYSQPLKE 244
Y YD + D+WSLGITA E+ G+PP M ++ + I ++ PP L ++ +
Sbjct: 209 YDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNH 268
Query: 245 FIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVILKEL 283
FI+ CL +D + RP L IK G + K+L
Sbjct: 269 FISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQL 307
>7293601 [T] KOG0577 Serine/threonine protein kinase
Length = 1039
Score = 179 bits (455), Expect = 1e-44
Identities = 109/277 (39%), Positives = 155/277 (55%), Gaps = 12/277 (4%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQT 72
+F+ IG G FG VY A T+++ AIK ++ ++++ +DI KEI+FL L
Sbjct: 26 IFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNH- 84
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSLRTL-LRPGIIEEKYIGVIMREILVALISIHRD 131
PN Y G YL ++ W++MEYC G + + + + E I I +L L +H
Sbjct: 85 PNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSL 144
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVY 189
IHRDIKA NIL+ +NG VKL DFG AA + + GTPYWMAPEVI M+
Sbjct: 145 GRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPA----NSFVGTPYWMAPEVILAMDEGQ 200
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALC 249
YD KVD+WSLGIT E+A PPY +M A+ A+ I +++ P L ++S F+ LC
Sbjct: 201 YDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELC 260
Query: 250 LDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITR 286
L + P ERP + +L + + + S +L ELI R
Sbjct: 261 LKKMPAERPSSAKLLTHAYVTRPR--SDTVLLELIAR 295
>CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 545
Score = 179 bits (454), Expect = 2e-44
Identities = 102/284 (35%), Positives = 152/284 (52%), Gaps = 27/284 (9%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+K E IG G V+ A+ + + AIK +NL+ + V+++ EIQ +S PN+
Sbjct: 57 YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNH-PNV 115
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRP------------GIIEEKYIGVIMREILV 123
YY S++ +LWV+M GS+ +L+ G+++E I ++RE+L
Sbjct: 116 VSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLK 175
Query: 124 ALISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQS------MLKRQTMAGTPY 177
L H + IHRDIKA NIL+A++G++++ DFGV+ L+ S R T GTP
Sbjct: 176 GLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPC 235
Query: 178 WMAPEVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEG-- 235
WMAPEV+ + YD K DIWSLGI A E+ATG PY ++ + + ++ PP LE
Sbjct: 236 WMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNA 295
Query: 236 ------REYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEK 273
+ Y + K I CL +DP +RP A EL K K+ K
Sbjct: 296 ERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFKKGK 339
>Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1152
Score = 177 bits (450), Expect = 6e-44
Identities = 116/341 (34%), Positives = 185/341 (54%), Gaps = 28/341 (8%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G FG VYKA + +T + A KV++ +E+E+ED EI L+S PNI +
Sbjct: 40 LGDGAFGKVYKAQNKETSVLAAAKVIDT-KSEEELEDYMVEIDILASCDH-PNIVKLLDA 97
Query: 82 YLIDTKLWVIMEYCAGGSLRTLL----RPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
+ + LW+++E+CAGG++ ++ RP + E I V+ ++ L AL +H + +IHRD
Sbjct: 98 FYYENNLWILIEFCAGGAVDAVMLELERP--LTESQIQVVCKQTLDALNYLHDNKIIHRD 155
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM----EGVYYDTK 193
+KA NIL +G +KL DFGV+A+ ++++ +R + GTPYWMAPEV+M + YD K
Sbjct: 156 LKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYK 215
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRL-EGREYSQPLKEFIALCLDE 252
D+WSLGIT E+A PP+ + +R + I KS+PP L + +S K+F+ CL++
Sbjct: 216 ADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEK 275
Query: 253 DPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLL-FREKNEQYKHEEESHTSSKQNP 311
+ R +L + + + S ++ELI E+ E K E+E + P
Sbjct: 276 NVDARWTTSQLLQHPFVTVD---SNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLP 332
Query: 312 NSSIEGNASQDAGSFTEKEPEDIDIKWDFDSLSSREYILEN 352
+ + AS D + +E D LS ILE+
Sbjct: 333 IPASK-RASSDLSIASSEE----------DKLSQNACILES 362
>Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 681
Score = 171 bits (434), Expect = 4e-42
Identities = 95/251 (37%), Positives = 145/251 (56%), Gaps = 4/251 (1%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IG G G+V A + + A+K+++L + E + E+ + + N+ Y S
Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDL-RKQQRRELLFNEVVIMRDYQHF-NVVEMYKS 470
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
YL+ +LWV+ME+ GG+L ++ + E+ I + +L AL +H VIHRDIK+
Sbjct: 471 YLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSD 530
Query: 142 NILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGI 201
+IL+ +G VKL DFG AQ+S+ + KR+++ GTPYWMAPEVI + Y T+VDIWSLGI
Sbjct: 531 SILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL-YATEVDIWSLGI 589
Query: 202 TAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP-LKEFIALCLDEDPKERPYA 260
E+ G PPY ++AM+ + S PP+L+ P L++F+ L DP+ER A
Sbjct: 590 MVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATA 649
Query: 261 EELFKSKLIKQ 271
+EL + Q
Sbjct: 650 QELLDHPFLLQ 660
>CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1228
Score = 171 bits (434), Expect = 4e-42
Identities = 98/279 (35%), Positives = 151/279 (53%), Gaps = 7/279 (2%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G FG V KA +++A +E+ED EI+ LS K P + Y +
Sbjct: 40 LGDGAFGKVEKAVSRTDPKLFAASKSIEIQEGEELEDFLVEIEILSECKGHPVMLGLYST 99
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRP--GIIEEKYIGVIMREILVALISIHRDNVIHRDIK 139
Y + KL +++E+C GG++ ++ +++E I I + AL +H NVIHRD+K
Sbjct: 100 YFFENKLTMLLEFCGGGAVDNIIVELGHVLKEDQIRYIGYYVCDALKWLHSQNVIHRDLK 159
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY----YDTKVD 195
A NIL+ +G V+L DFGV+A+L KR T GTPYWMAPEV+ + YD D
Sbjct: 160 AGNILLTQDGQVRLADFGVSAKLKSEREKRDTFIGTPYWMAPEVMACETFKDQPYDCISD 219
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPR-LEGREYSQPLKEFIALCLDEDP 254
IWS GIT E+A G PP+ + +R + + KS+PP L+ +++ + + CL +DP
Sbjct: 220 IWSFGITLIEMAQGEPPHSDVSVMRVIIKVQKSEPPTLLQPSHWTRSFSDILTRCLVKDP 279
Query: 255 KERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREK 293
+ RP A E+FK + + +I+ L Y +E+
Sbjct: 280 RNRPPAAEIFKHQWFQNAPSKRKMIMDLLAEMYADVQEE 318
>At1g53570 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 171 bits (433), Expect = 5e-42
Identities = 103/260 (39%), Positives = 144/260 (54%), Gaps = 7/260 (2%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIK---VLNLDNTEDE-VEDIRKEIQFLSSLKQ 71
+K+ + +G G FG VY F+ + ++ AIK V++ D T E ++ + +EI L+ L
Sbjct: 214 WKKGKFLGSGTFGQVYLGFNSEKGKMCAIKEVKVISDDQTSKECLKQLNQEINLLNQLCH 273
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHR 130
PNI YYGS L + L V +EY +GGS+ LL+ G E I R+IL L +H
Sbjct: 274 -PNIVQYYGSELSEETLSVYLEYVSGGSIHKLLKDYGSFTEPVIQNYTRQILAGLAYLHG 332
Query: 131 DNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYY 190
N +HRDIK ANIL+ NG +KL DFG+A ++ + + G+PYWMAPEV+M Y
Sbjct: 333 RNTVHRDIKGANILVDPNGEIKLADFGMAKHVT-AFSTMLSFKGSPYWMAPEVVMSQNGY 391
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
VDIWSLG T E+AT PP+ E + A+ I SK S K FI LCL
Sbjct: 392 THAVDIWSLGCTILEMATSKPPWSQFEGVAAIFKIGNSKDTPEIPDHLSNDAKNFIRLCL 451
Query: 251 DEDPKERPYAEELFKSKLIK 270
+P RP A +L + ++
Sbjct: 452 QRNPTVRPTASQLLEHPFLR 471
>CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 540
Score = 171 bits (432), Expect = 7e-42
Identities = 95/258 (36%), Positives = 149/258 (56%), Gaps = 4/258 (1%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IG G GVV A+ + T+Q+ A+K +NL + E + E+ L Q PNI ++ S
Sbjct: 255 IGEGSTGVVEAAYKISTKQIVAVKRMNL-RKQQRRELLFNEVSILRQY-QHPNIVRFFSS 312
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
+L+D +LWV+ME+ GGSL ++ + E I I R++L AL +H VIHRDIK+
Sbjct: 313 HLVDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRDIKSD 372
Query: 142 NILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGI 201
+IL+ +G+VKL DFG QLS+ + +R+++ GTPYW A EVI YDT+ DIWS GI
Sbjct: 373 SILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREP-YDTRADIWSFGI 431
Query: 202 TAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGR-EYSQPLKEFIALCLDEDPKERPYA 260
E+ G PP+ + + +AM+ I R + S L E ++ C+ +D +R A
Sbjct: 432 MLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPA 491
Query: 261 EELFKSKLIKQEKGTSTV 278
++L + + + +S++
Sbjct: 492 KDLLRHPFFAKAQHSSSI 509
>CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 542
Score = 171 bits (432), Expect = 7e-42
Identities = 95/258 (36%), Positives = 149/258 (56%), Gaps = 4/258 (1%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IG G GVV A+ + T+Q+ A+K +NL + E + E+ L Q PNI ++ S
Sbjct: 257 IGEGSTGVVEAAYKISTKQIVAVKRMNL-RKQQRRELLFNEVSILRQY-QHPNIVRFFSS 314
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
+L+D +LWV+ME+ GGSL ++ + E I I R++L AL +H VIHRDIK+
Sbjct: 315 HLVDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRDIKSD 374
Query: 142 NILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGI 201
+IL+ +G+VKL DFG QLS+ + +R+++ GTPYW A EVI YDT+ DIWS GI
Sbjct: 375 SILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREP-YDTRADIWSFGI 433
Query: 202 TAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGR-EYSQPLKEFIALCLDEDPKERPYA 260
E+ G PP+ + + +AM+ I R + S L E ++ C+ +D +R A
Sbjct: 434 MLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPA 493
Query: 261 EELFKSKLIKQEKGTSTV 278
++L + + + +S++
Sbjct: 494 KDLLRHPFFAKAQHSSSI 511
>CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 378
Score = 170 bits (431), Expect = 9e-42
Identities = 99/266 (37%), Positives = 153/266 (57%), Gaps = 6/266 (2%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
++ K+ IG G G V+ A + V A+K + T+ + E + EI+ + + PN+
Sbjct: 108 YEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAF-KTQPKKEMLLTEIKVMKQYRH-PNL 165
Query: 76 THYYGSYLIDTK-LWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+Y SYL+D LWV+M+Y GG+L ++ ++E I +++E L AL +HR +++
Sbjct: 166 VNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIV 225
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIK+ N+L+ NG VKL D G AQ+ Q KR T+ GTPYWM+PE I+ Y+ KV
Sbjct: 226 HRDIKSDNVLLGMNGEVKLTDMGFCAQI-QPGSKRDTVVGTPYWMSPE-ILNKKQYNYKV 283
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKEFIALCLDED 253
DIWSLGI A E+ G PPY ++A+ +I ++ P ++ R+ S F+ CL D
Sbjct: 284 DIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVD 343
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVI 279
P +R EL +K+ K S++I
Sbjct: 344 PDQRADTTELLAHPFLKKAKPLSSLI 369
>At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 594
Score = 170 bits (431), Expect = 9e-42
Identities = 98/273 (35%), Positives = 155/273 (55%), Gaps = 21/273 (7%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
E +G G VY+A + ++ A+K+L+L+ +++E IRKE+ +S + PN+ +
Sbjct: 20 EEVGEGVSATVYRARCIALNEIVAVKILDLEKCRNDLETIRKEVHIMSLIDH-PNLLKAH 78
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLR---PGIIEEKYIGVIMREILVALISIHRDNVIHR 136
S++ + LW++M Y +GGS L++ P +E+ I ++RE+L AL+ +HR IHR
Sbjct: 79 CSFIDSSSLWIVMPYMSGGSCFHLMKSVYPEGLEQPIIATLLREVLKALVYLHRQGHIHR 138
Query: 137 DIKAANILIANNGSVKLCDFGVAAQLSQS---MLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
D+KA NILI + G VKL DFGV+A + S M R T GTP WMAPEV+ + YD K
Sbjct: 139 DVKAGNILIHSKGVVKLGDFGVSACMFDSGERMQTRNTFVGTPCWMAPEVMQQLDGYDFK 198
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE---GREYSQPLKEFIALCL 250
+A G+ P+ ++ + M ++ PPRL+ +++S+ +E IA CL
Sbjct: 199 Y-----------LAHGHAPFSKYPPMKVLLMTLQNAPPRLDYDRDKKFSKSFRELIAACL 247
Query: 251 DEDPKERPYAEELFKSKLIKQEKGTSTVILKEL 283
+DPK+RP A +L K K + T + K L
Sbjct: 248 VKDPKKRPTAAKLLKHPFFKHARSTDYLSRKIL 280
>Hs14771959 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 719
Score = 169 bits (428), Expect = 2e-41
Identities = 96/259 (37%), Positives = 148/259 (57%), Gaps = 4/259 (1%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IG G G+V A T + A+K ++L + E + E+ + N+ Y S
Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDL-RKQQRRELLFNEVVIMRDYHHD-NVVDMYSS 512
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
YL+ +LWV+ME+ GG+L ++ + E+ I + +L AL +H VIHRDIK+
Sbjct: 513 YLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSD 572
Query: 142 NILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGI 201
+IL+ ++G +KL DFG AQ+S+ + KR+++ GTPYWMAPEVI + Y T+VDIWSLGI
Sbjct: 573 SILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISR-LPYGTEVDIWSLGI 631
Query: 202 TAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEG-REYSQPLKEFIALCLDEDPKERPYA 260
E+ G PPY + ++AM+ I S PPR++ + S L+ F+ L L +P +R A
Sbjct: 632 MVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATA 691
Query: 261 EELFKSKLIKQEKGTSTVI 279
+EL +K S ++
Sbjct: 692 QELLGHPFLKLAGPPSCIV 710
>SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1062
Score = 168 bits (426), Expect = 3e-41
Identities = 95/248 (38%), Positives = 141/248 (56%), Gaps = 7/248 (2%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT-EDEVEDIRKEIQFLSSLKQTPNITHY 78
+ +G+G FG VY+ ++K + A+K + L + ++ I+ EI L +L PNI Y
Sbjct: 13 DCLGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDH-PNIVKY 71
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNVIHRD 137
GSY + L +I+EYC GSLR++ + G I E + + ++L L+ +H VIHRD
Sbjct: 72 RGSYQTNDSLCIILEYCENGSLRSICKNFGKIPENLVALYTFQVLQGLLYLHNQGVIHRD 131
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIW 197
IK ANIL +G++KL DFGVA ++ + L+ ++ G+PYWMAPEVI E V T DIW
Sbjct: 132 IKGANILTTKDGTIKLADFGVATKI--NALEDHSVVGSPYWMAPEVI-ELVGATTASDIW 188
Query: 198 SLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKER 257
S+G T E+ GNPPY ++ A+ + K + P L S K F+ C +DP R
Sbjct: 189 SVGCTVIELLDGNPPYYDLDPTSALFRMVKDEHPPLPS-NISSAAKSFLMQCFQKDPNLR 247
Query: 258 PYAEELFK 265
+L K
Sbjct: 248 IKTRKLLK 255
>Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 591
Score = 168 bits (426), Expect = 3e-41
Identities = 95/259 (36%), Positives = 150/259 (57%), Gaps = 4/259 (1%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IG G G+V A + ++ A+K ++L + E + E+ + Q N+ Y S
Sbjct: 327 IGEGSTGIVCIATVRSSGKLVAVKKMDL-RKQQRRELLFNEVVIMRDY-QHENVVEMYNS 384
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
YL+ +LWV+ME+ GG+L ++ + E+ I + +L AL +H VIHRDIK+
Sbjct: 385 YLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSD 444
Query: 142 NILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGI 201
+IL+ ++G VKL DFG AQ+S+ + +R+++ GTPYWMAPE+I + Y +VDIWSLGI
Sbjct: 445 SILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR-LPYGPEVDIWSLGI 503
Query: 202 TAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEG-REYSQPLKEFIALCLDEDPKERPYA 260
E+ G PPY + ++AM+MI + PPRL+ + S LK F+ L DP +R A
Sbjct: 504 MVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATA 563
Query: 261 EELFKSKLIKQEKGTSTVI 279
EL K + + ++++
Sbjct: 564 AELLKHPFLAKAGPPASIV 582
>At3g13530 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1368
Score = 167 bits (422), Expect = 1e-40
Identities = 114/376 (30%), Positives = 192/376 (50%), Gaps = 22/376 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN-TEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
IG+G +G VYK ++ AIK ++L+N ++++ I +EI L +L NI Y G
Sbjct: 26 IGKGAYGRVYKGLDLENGDFVAIKQVSLENIVQEDLNTIMQEIDLLKNLNHK-NIVKYLG 84
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILVALISIHRDNVIHRD 137
S T L +I+EY GSL +++P G E + V + ++L L+ +H VIHRD
Sbjct: 85 SSKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIHRD 144
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI-MEGVYYDTKVDI 196
IK ANIL G VKL DFGVA +L+++ + ++ GTPYWMAPEVI M GV DI
Sbjct: 145 IKGANILTTKEGLVKLADFGVATKLNEADVNTHSVVGTPYWMAPEVIEMSGVC--AASDI 202
Query: 197 WSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKE 256
WS+G T E+ T PPY ++ + A+ I + P + S + +F+ C +D ++
Sbjct: 203 WSVGCTVIELLTCVPPYYDLQPMPALFRIVQDDNPPIPD-SLSPDITDFLRQCFKKDSRQ 261
Query: 257 RPYAEELFKSKLIKQEKGTSTVILKELIT-RYLLFREKNEQYKHEEESHTSSKQNPNSSI 315
RP A+ L I+ + L+ T +Y+ +E + ++E + ++ +
Sbjct: 262 RPDAKTLLSHPWIRNSRRALQSSLRHSGTIKYM--KEATASSEKDDEGSQDAAESLSGEN 319
Query: 316 EGNASQDAGS----------FTEKEPEDIDIKWDFDSLSSREYILENDINVEAIPEEADW 365
G + D+ S +EK+ + + +S + I+ + + +I E++
Sbjct: 320 VGISKTDSKSKLPLVGVSSFRSEKDQSTPSDLGEEGTDNSEDDIMSDQVPTLSIHEKSSD 379
Query: 366 IKYSPQEVNYAYPEEE 381
K +PQ+V+ + + E
Sbjct: 380 AKGTPQDVSDFHGKSE 395
>7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 326
Score = 166 bits (419), Expect = 2e-40
Identities = 98/301 (32%), Positives = 162/301 (53%), Gaps = 17/301 (5%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
F+ E I +G V++A + ++ A+K+ + D E+ I +E + L PN+
Sbjct: 16 FEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYD--EEHQVSIEEEYRTLRDYCDHPNL 73
Query: 76 THYYGSYLIDT-----KLWVIMEYCAGGSLRTLLRPGI-----IEEKYIGVIMREILVAL 125
+YG Y + ++W +MEYCAGG+ ++ + + E++I I+RE A
Sbjct: 74 PEFYGVYKLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRAA 133
Query: 126 ISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI- 184
I ++R++V+HRDI+ NIL+ NG VKLCDFG++ Q+ ++ KR T G+P WMAPEV+
Sbjct: 134 IELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVS 193
Query: 185 -MEGVYYD--TKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRL-EGREYSQ 240
ME D + D+W+LGIT E+A G PP+ M RAM I ++ PP L +SQ
Sbjct: 194 AMESREPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQ 253
Query: 241 PLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHE 300
+ +FI+ L+++ + RP E+ + + + + ++ L R+ YK
Sbjct: 254 QINDFISESLEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIAEMLELSRDVKTLYKEP 313
Query: 301 E 301
E
Sbjct: 314 E 314
>7300149 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 569
Score = 165 bits (418), Expect = 3e-40
Identities = 91/251 (36%), Positives = 148/251 (58%), Gaps = 7/251 (2%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+K + +G+G G+V+ A ++ + A+K +++ N + + I EI+ L N+
Sbjct: 293 YKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSK-DLILTEIRVLKDFNHK-NL 350
Query: 76 THYYGSYLIDTK--LWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNV 133
++ +YL++ + LWV+MEY GG L ++ +++E+ I + RE L A+ +H +
Sbjct: 351 VNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGI 410
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
IHRDIK+ N+L+ +GSVK+ DFG A + + KRQTM GTPYWMAPEV+ Y K
Sbjct: 411 IHRDIKSDNVLLGMDGSVKVTDFGFCANI-EGDEKRQTMVGTPYWMAPEVVTR-KKYGKK 468
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP-LKEFIALCLDE 252
VDIWS+GI A E+ G PPY + +RA+ +I + P ++ + P L++F+ CL
Sbjct: 469 VDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQV 528
Query: 253 DPKERPYAEEL 263
+ R A+EL
Sbjct: 529 EVDRRATADEL 539
>YAR019c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 974
Score = 165 bits (417), Expect = 4e-40
Identities = 102/251 (40%), Positives = 146/251 (57%), Gaps = 14/251 (5%)
Query: 19 KEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
K++IGRG +GVVYKA + T QV AIK + +N E E+ DI EI L +L NI Y
Sbjct: 28 KQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDE-ELNDIMAEISLLKNLNHN-NIVKY 85
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRPGI--IEEKYIGVIMREILVALISIHRDNVIHR 136
+G +L++++EYCA GSLR L+ + E + + L+ L +H + VIHR
Sbjct: 86 HGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHR 145
Query: 137 DIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDI 196
DIKAANIL++ + +VKL DFGV+ ++ S L T+AGT WMAPE I+ T DI
Sbjct: 146 DIKAANILLSADNTVKLADFGVSTIVNSSAL---TLAGTLNWMAPE-ILGNRGASTLSDI 201
Query: 197 WSLGITAYEIATGNPPYCHMEAIRAMQMITKSK--PPRLEGREYSQPLKEFIALCLDEDP 254
WSLG T E+ T NPPY ++ + PP +S+PLK+F++ C ++
Sbjct: 202 WSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPP----SSFSEPLKDFLSKCFVKNM 257
Query: 255 KERPYAEELFK 265
+RP A++L K
Sbjct: 258 YKRPTADQLLK 268
>Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1191
Score = 165 bits (417), Expect = 4e-40
Identities = 105/283 (37%), Positives = 152/283 (53%), Gaps = 27/283 (9%)
Query: 92 MEYCAGGSLRTLLRP---GIIEEKYIGVIMREILVALISIHRDNVIHRDIKAANILIANN 148
ME+C GS+ L++ ++E I I REIL L +H VIHRDIK N+L+ N
Sbjct: 1 MEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTEN 60
Query: 149 GSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM----EGVYYDTKVDIWSLGITAY 204
VKL DFGV+AQL +++ +R T GTPYWMAPEVI YD + DIWSLGITA
Sbjct: 61 AEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAI 120
Query: 205 EIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERPYAEELF 264
E+A G PP C M +RA+ +I ++ PPRL+ +++S+ +FI CL + RP E+L
Sbjct: 121 EMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLL 180
Query: 265 KSKLIKQE--KGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNSSIEGNASQD 322
K I+ + + + LK+ I R R + E+ ++E G+ +D
Sbjct: 181 KFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYE--------------YSGSEEED 226
Query: 323 AGSFTEKEPEDIDIKWDFDSLSSREYI---LENDINVEAIPEE 362
E EP I + +S RE++ EN N EA+ ++
Sbjct: 227 DSHGEEGEPSSI-MNVPGESTLRREFLRLQQENKSNSEALKQQ 268
>At5g66850 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 376
Score = 164 bits (415), Expect = 7e-40
Identities = 97/268 (36%), Positives = 147/268 (54%), Gaps = 17/268 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNL----DNTEDEVEDIRKEIQFLSSLKQ 71
+K+ ++IGRG FG VY A + +T + A+K + L + + ++ + +EI+ LS+L Q
Sbjct: 5 WKKGKLIGRGTFGSVYVASNSETGALCAMKEVELFPDDPKSAECIKQLEQEIKLLSNL-Q 63
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP--GIIEEKYIGVIMREILVALISIH 129
PNI Y+GS ++ + ++ +EY GS+ +R G + E + R IL L +H
Sbjct: 64 HPNIVQYFGSETVEDRFFIYLEYVHPGSINKYIRDHCGTMTESVVRNFTRHILSGLAYLH 123
Query: 130 RDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY 189
+HRDIK AN+L+ +G VKL DFG+A L+ ++ G+PYWMAPEV+M+ V
Sbjct: 124 NKKTVHRDIKGANLLVDASGVVKLADFGMAKHLT-GQRADLSLKGSPYWMAPEVLMQAVM 182
Query: 190 YDTK-------VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPL 242
VDIWSLG T E+ TG PP+ E AM + + PP E S
Sbjct: 183 QKDSNPDLAFAVDIWSLGCTIIEMFTGKPPWSEFEGAAAMFKVMRDSPPIPE--SMSPEG 240
Query: 243 KEFIALCLDEDPKERPYAEELFKSKLIK 270
K+F+ LC +P ERP A L + + +K
Sbjct: 241 KDFLRLCFQRNPAERPTASMLLEHRFLK 268
>At1g09000 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 666
Score = 162 bits (410), Expect = 2e-39
Identities = 96/277 (34%), Positives = 157/277 (56%), Gaps = 19/277 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNL-------DNTEDEVEDIRKEIQFLSS 68
+++ ++IGRG FG VY ++ + ++ A+K + + + T+ ++++ +E++ L +
Sbjct: 69 WRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKN 128
Query: 69 LKQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALIS 127
L PNI Y G+ D L +++E+ GGS+ +LL G E + R++L+ L
Sbjct: 129 LSH-PNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEY 187
Query: 128 IHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQ--SMLKRQTMAGTPYWMAPEVIM 185
+H ++HRDIK ANIL+ N G +KL DFG + Q+++ +M ++M GTPYWMAPEVI+
Sbjct: 188 LHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVIL 247
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHM-EAIRAMQMI--TKSKPPRLEGREYSQPL 242
+ + DIWS+G T E+ TG P+ + + A+ I TKS PP + S
Sbjct: 248 Q-TGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPD--TLSSDA 304
Query: 243 KEFIALCLDEDPKERPYAEELFKSKLI--KQEKGTST 277
K+F+ CL E P RP A EL K + K ++ ST
Sbjct: 305 KDFLLKCLQEVPNLRPTASELLKHPFVMGKHKESAST 341
>SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 589
Score = 161 bits (407), Expect = 6e-39
Identities = 104/263 (39%), Positives = 141/263 (53%), Gaps = 10/263 (3%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQV-----YAIKVLNLDNTEDEVEDIRKEIQFLSSLK 70
F K +G+G G VY A V +Q+ AIK ++L + E I EI +
Sbjct: 309 FNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQ-CQTRKELILNEITVMRESI 367
Query: 71 QTPNITHYYGSYLI-DTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIH 129
PNI Y S+L+ + LWV+MEY GSL ++ + E I I E + +H
Sbjct: 368 H-PNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSKLTEAQIARICLETCKGIQHLH 426
Query: 130 RDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY 189
N+IHRDIK+ N+L+ N+G++K+ DFG A+LS KR TM GTPYWMAPEV+ +
Sbjct: 427 ARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVVKQN-E 485
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGRE-YSQPLKEFIAL 248
Y TKVDIWSLGI E+ PPY + IRA+ +I K+ P L+ S+ LK F+
Sbjct: 486 YGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNS 545
Query: 249 CLDEDPKERPYAEELFKSKLIKQ 271
CL D R A EL + Q
Sbjct: 546 CLTIDTIFRATAAELLTHSFLNQ 568
>At3g07980 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1367
Score = 161 bits (407), Expect = 6e-39
Identities = 94/257 (36%), Positives = 142/257 (54%), Gaps = 9/257 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT-EDEVEDIRKEIQFLSSLKQTPNITHYYG 80
IG+G +G VY ++ AIK ++L+N ++++ I +EI L +L NI Y G
Sbjct: 26 IGKGAYGRVYIGLDLENGDFVAIKQVSLENIGQEDLNTIMQEIDLLKNLNHK-NIVKYLG 84
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLLRP---GIIEEKYIGVIMREILVALISIHRDNVIHRD 137
S T L +I+EY GSL +++P G E + V + ++L L+ +H VIHRD
Sbjct: 85 SLKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVTVYIAQVLEGLVYLHEQGVIHRD 144
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI-MEGVYYDTKVDI 196
IK ANIL G VKL DFGVA +L+++ ++ GTPYWMAPEVI + GV DI
Sbjct: 145 IKGANILTTKEGLVKLADFGVATKLNEADFNTHSVVGTPYWMAPEVIELSGVC--AASDI 202
Query: 197 WSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKE 256
WS+G T E+ T PPY ++ + A+ I + P + S + +F+ LC +D ++
Sbjct: 203 WSVGCTIIELLTCVPPYYDLQPMPALYRIVQDDTPPIPD-SLSPDITDFLRLCFKKDSRQ 261
Query: 257 RPYAEELFKSKLIKQEK 273
RP A+ L I+ +
Sbjct: 262 RPDAKTLLSHPWIRNSR 278
>At1g63700 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 883
Score = 161 bits (407), Expect = 6e-39
Identities = 95/260 (36%), Positives = 143/260 (54%), Gaps = 7/260 (2%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNL----DNTEDEVEDIRKEIQFLSSLKQ 71
+K+ ++G G FG VY F+ ++ ++ A+K + L + + + + +EI LS L+
Sbjct: 400 WKKGRLLGMGSFGHVYLGFNSESGEMCAMKEVTLCSDDPKSRESAQQLGQEISVLSRLRH 459
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHR 130
NI YYGS +D KL++ +EY +GGS+ LL+ G E I ++IL L +H
Sbjct: 460 Q-NIVQYYGSETVDDKLYIYLEYVSGGSIYKLLQEYGQFGENAIRNYTQQILSGLAYLHA 518
Query: 131 DNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYY 190
N +HRDIK ANIL+ +G VK+ DFG+A ++ + + G+PYWMAPEVI
Sbjct: 519 KNTVHRDIKGANILVDPHGRVKVADFGMAKHIT-AQSGPLSFKGSPYWMAPEVIKNSNGS 577
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
+ VDIWSLG T E+AT PP+ E + AM I SK S+ K+F+ CL
Sbjct: 578 NLAVDIWSLGCTVLEMATTKPPWSQYEGVPAMFKIGNSKELPDIPDHLSEEGKDFVRKCL 637
Query: 251 DEDPKERPYAEELFKSKLIK 270
+P RP A +L ++
Sbjct: 638 QRNPANRPTAAQLLDHAFVR 657
>Hs18602554 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 227
Score = 159 bits (403), Expect = 2e-38
Identities = 84/209 (40%), Positives = 128/209 (61%), Gaps = 2/209 (0%)
Query: 71 QTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHR 130
+ PNI ++ SYL+ +L+V++EY A GSL ++ ++E I + RE L AL +H
Sbjct: 5 KNPNIVNFLDSYLVGDELFVVVEYLARGSLTDVVTETCMDEAQIAAVCRESLQALEFLHA 64
Query: 131 DNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYY 190
+ VIHRDIK+ ++L+ GSVKL DFG AQ++ KR T+ TPYWMAPEV+ Y
Sbjct: 65 NQVIHRDIKSDSVLLGMEGSVKLTDFGFCAQITPEQSKRSTVVRTPYWMAPEVVTRKA-Y 123
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPL-KEFIALC 249
KV++WSLGI A E+ G PPY + +RA+ +I + P L+ E P+ ++F+ C
Sbjct: 124 GPKVNVWSLGIMATEMVEGEPPYLNENPLRALCLIATNGIPELQNPETLSPIFRDFLNRC 183
Query: 250 LDEDPKERPYAEELFKSKLIKQEKGTSTV 278
L+ D ++R A+EL + +K K S++
Sbjct: 184 LETDVEKRGSAKELLQHLFLKLAKLLSSL 212
>At1g54960 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 585
Score = 157 bits (398), Expect = 6e-38
Identities = 91/265 (34%), Positives = 151/265 (56%), Gaps = 17/265 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNL-------DNTEDEVEDIRKEIQFLSS 68
+++ ++IGRG FG VY ++ + ++ A+K + + + T+ ++++ +E++ L +
Sbjct: 68 WRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKN 127
Query: 69 LKQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALIS 127
L PNI Y G+ D L +++E+ GGS+ +LL G E + ++L+ L
Sbjct: 128 LSH-PNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLEY 186
Query: 128 IHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQ--SMLKRQTMAGTPYWMAPEVIM 185
+H ++HRDIK ANIL+ N G +KL DFG + Q+++ ++ ++M GTPYWMAPEVI+
Sbjct: 187 LHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVIL 246
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHM-EAIRAMQMI--TKSKPPRLEGREYSQPL 242
+ + DIWS+G T E+ TG P+ + I A+ I TKS PP + S
Sbjct: 247 Q-TGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIPD--NISSDA 303
Query: 243 KEFIALCLDEDPKERPYAEELFKSK 267
+F+ CL ++P RP A EL K K
Sbjct: 304 NDFLLKCLQQEPNLRPTASELLKVK 328
>At1g23700 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 473
Score = 155 bits (391), Expect = 4e-37
Identities = 94/265 (35%), Positives = 151/265 (56%), Gaps = 18/265 (6%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
E IG G VY+A + ++ AIK+ NL+ +++E IRKE+ LS + PN+ +
Sbjct: 20 EEIGDG----VYRARCILLDEIVAIKIWNLEKCTNDLETIRKEVHRLSLIDH-PNLLRVH 74
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLR---PGIIEEKYIGVIMREILVALISIHRDNVIHR 136
S++ + LW++M + + GS +++ P +EE I +++REIL AL+ +H IHR
Sbjct: 75 CSFIDSSSLWIVMPFMSCGSSLNIMKSVYPNGLEEPVIAILLREILKALVYLHGLGHIHR 134
Query: 137 DIKAANILIANNGSVKLCDFGVAAQLSQSMLK-----RQTMAGTPYWMAPEVIMEGV-YY 190
++KA N+L+ + G+VKL DF V+A + S+ + T G P MAPE M+ V Y
Sbjct: 135 NVKAGNVLVDSEGTVKLGDFEVSASMFDSVERMRTSSENTFVGNPRRMAPEKDMQQVDGY 194
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
D KVDIWS G+TA E+A G+ P + + + P E ++S+ +E +A CL
Sbjct: 195 DFKVDIWSFGMTALELAHGHSP----TTVLPLNLQNSPFPNYEEDTKFSKSFRELVAACL 250
Query: 251 DEDPKERPYAEELFKSKLIKQEKGT 275
EDP++RP A +L + ++Q T
Sbjct: 251 IEDPEKRPTASQLLEYPFLQQTLST 275
>Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 448
Score = 152 bits (383), Expect = 3e-36
Identities = 93/284 (32%), Positives = 148/284 (51%), Gaps = 14/284 (4%)
Query: 19 KEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
++ +G G G VYKA+HV + ++ A+KV+ LD T + + I E++ L + I +
Sbjct: 169 RDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSS-YIIGF 227
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
YG++ ++ ++ + E+ GGSL + + E +G I ++ L + ++HRD+
Sbjct: 228 YGAFFVENRISICTEFMDGGSLDVYRK---MPEHVLGRIAVAVVKGLTYLWSLKILHRDV 284
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K +N+L+ G VKLCDFGV+ QL S+ K T GT +MAPE I G Y D+WS
Sbjct: 285 KPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERI-SGEQYGIHSDVWS 341
Query: 199 LGITAYEIATGNPPYCHME-------AIRAMQMITKSKPPRLEGREYSQPLKEFIALCLD 251
LGI+ E+A G PY ++ ++ +Q I P L E+S+P FI C+
Sbjct: 342 LGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMR 401
Query: 252 EDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNE 295
+ PKERP EEL I Q + ++ + R L R +
Sbjct: 402 KQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQ 445
>At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 151 bits (382), Expect = 4e-36
Identities = 93/261 (35%), Positives = 139/261 (52%), Gaps = 11/261 (4%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
++IG+G GVV H T Q +A+KV+ L+ E + I +E++ S Q PN+ Y
Sbjct: 74 KVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQS-SQCPNLVTSY 132
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRD-NVIHRD 137
S+ + + +I+EY GGSL L+ I + Y+ I R++L LI +H D ++IHRD
Sbjct: 133 QSFYDNGAISLILEYMDGGSLADFLKSVKAIPDSYLSAIFRQVLQGLIYLHHDRHIIHRD 192
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIW 197
+K +N+LI + G VK+ DFGV+ ++ + T GT +M+PE I+ G Y K DIW
Sbjct: 193 LKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIV-GNKYGNKSDIW 251
Query: 198 SLGITAYEIATGNPPYC-------HMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
SLG+ E ATG PY M+ I PP L +S L FI+ CL
Sbjct: 252 SLGLVVLECATGKFPYAPPNQEETWTSVFELMEAIVDQPPPALPSGNFSPELSSFISTCL 311
Query: 251 DEDPKERPYAEELFKSKLIKQ 271
+DP R A+EL + + +
Sbjct: 312 QKDPNSRSSAKELMEHPFLNK 332
>At3g06030 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 651
Score = 151 bits (382), Expect = 4e-36
Identities = 91/267 (34%), Positives = 152/267 (56%), Gaps = 17/267 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNL-------DNTEDEVEDIRKEIQFLSS 68
+++ E+IG G FG VY ++ + ++ AIK + + + T+ + ++ +E+Q L +
Sbjct: 68 WRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKN 127
Query: 69 LKQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALIS 127
L PNI Y G+ L ++ME+ GGS+ +LL G E I + +++L+ L
Sbjct: 128 LSH-PNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEY 186
Query: 128 IHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQ--SMLKRQTMAGTPYWMAPEVIM 185
+H + ++HRDIK ANIL+ N G ++L DFG + ++ + ++ ++M GTPYWMAPEVI+
Sbjct: 187 LHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVIL 246
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHM-EAIRAMQMI--TKSKPPRLEGREYSQPL 242
+ + DIWS+G T E+ATG PP+ + A+ I TK+ PP E + S
Sbjct: 247 Q-TGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPE--DLSPEA 303
Query: 243 KEFIALCLDEDPKERPYAEELFKSKLI 269
K+F+ CL ++P R A EL + +
Sbjct: 304 KDFLMKCLHKEPSLRLSATELLQHPFV 330
>Hs22065797 [T] KOG0577 Serine/threonine protein kinase
Length = 897
Score = 150 bits (379), Expect = 1e-35
Identities = 108/349 (30%), Positives = 168/349 (47%), Gaps = 36/349 (10%)
Query: 92 MEYCAGGSLRTL-LRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAANILIANNGS 150
MEYC G + L + ++E I I L L +H +IHRDIKA NIL+ G
Sbjct: 1 MEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQ 60
Query: 151 VKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVYYDTKVDIWSLGITAYEIAT 208
VKL DFG A+ S + + GTPYWMAPEVI M+ YD KVD+WSLGIT E+A
Sbjct: 61 VKLADFGSASMASPA----NSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAE 116
Query: 209 GNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERPYAEELFKSKL 268
PP +M A+ A+ I +++ P L+ E+S + F+ CL + P++RP +EEL K
Sbjct: 117 RKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIF 176
Query: 269 IKQEKGTSTVI---------LKELIT------RYLLFREKNE------QYKHEEESHTSS 307
+ +E+ + +I ++EL + LLF+E + Q + EE+ H
Sbjct: 177 VLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVG 236
Query: 308 KQNPNSSIEGNASQDAGSFT-EKEPEDIDIKWDFDSLSSREYILENDINVEAIPEEADWI 366
+ +S+ N S + S + + ++ D S ++E D + + I
Sbjct: 237 RTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGD---HTVMSNSSVI 293
Query: 367 KYSPQEVNYAYPEEEYYNSNKPYFPYYQGSTIGRTFNNNPNTAHLSTIQ 415
P+E NY + ++ P P + R ++ N H +TI+
Sbjct: 294 HLKPEEENYREEGDPRTRASDPQSP----PQVSRHKSHYRNREHFATIR 338
>YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 842
Score = 150 bits (378), Expect = 1e-35
Identities = 100/276 (36%), Positives = 145/276 (52%), Gaps = 30/276 (10%)
Query: 16 FKRKEIIGRGKFGVVYKA--FHVKTQQVYAIKVLNLDNTEDEVEDI------------RK 61
FK E G+G G VY A H+ T+ I+++N D E V D RK
Sbjct: 546 FKVIEKAGQGASGSVYLAERTHIPTES-NMIELINNDIDEPHVGDKVAIKQMVLSKQPRK 604
Query: 62 EIQFLSSL----KQTPNITHYYGSYL-IDTKLWVIMEYCAGGSLRTLLRPGI-------- 108
E+ L + NI ++ +YL D LWV+ME+ GGSL ++
Sbjct: 605 ELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSP 664
Query: 109 IEEKYIGVIMREILVALISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLK 168
+ E I I+RE L +H ++IHRDIK+ N+L+ VK+ DFG A+L+ K
Sbjct: 665 LTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSK 724
Query: 169 RQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS 228
R TM GTPYWMAPEV+ + YD K+D+WSLGI E+ G PPY + + ++A+ +I +
Sbjct: 725 RATMVGTPYWMAPEVVKQR-EYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATN 783
Query: 229 KPPRLEGRE-YSQPLKEFIALCLDEDPKERPYAEEL 263
P+L+ E S +K F+++CL D + R EEL
Sbjct: 784 GTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEEL 819
>At1g79640 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 150 bits (378), Expect = 1e-35
Identities = 119/403 (29%), Positives = 186/403 (45%), Gaps = 60/403 (14%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
E IG+G +V++A + +V AIK+L+ + ++ +I +E Q + L PN+ +
Sbjct: 17 EFIGQGVSALVHRALCIPFDEVVAIKILDFERDNCDLNNISREAQTMM-LVDHPNVLKSH 75
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLR---PGIIEEKYIGVIMREILVALISIHRDNVIHR 136
S++ D LWVIM Y +GGS +L+ P EE I I+RE L L +H+ IHR
Sbjct: 76 CSFVSDHNLWVIMPYMSGGSCLHILKAAYPDGFEEAIIATILREALKGLDYLHQHGHIHR 135
Query: 137 DIKAANILIANNGSVKLCDFGVAAQLSQS---MLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
D+KA NIL+ G+VKL DFGV+A L S R T GTP W
Sbjct: 136 DVKAGNILLGARGAVKLGDFGVSACLFDSGDRQRTRNTFVGTPCW--------------- 180
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDED 253
DIWS GIT E+A G+ P+ SK P ++ K+ IA CL +D
Sbjct: 181 ADIWSFGITGLELAHGHAPF--------------SKYPPMKS------FKQMIASCLVKD 220
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPNS 313
P +RP A++L K KQ + +S I ++L+ + + K+E + S +
Sbjct: 221 PSKRPSAKKLLKHSFFKQAR-SSDYIARKLLDGLPDLVNRVQAIKNEYKRGISGLSGSAT 279
Query: 314 SIEGNASQDAGSFTEKEPEDIDIKWDFDSLSSREYILENDINVEAIPEEADWIKYSPQEV 373
S++ SQD S +++ I K+ + ++ +++ + D SP
Sbjct: 280 SLQALDSQDTQSEIQEDTGQITNKY-------LQPLIHRSLSIARDKSDDDSSLASPSYD 332
Query: 374 NYAY--PEEEYYNSNKPYFPYYQGSTIGRTFNNNPNTAHLSTI 414
+Y Y P E + N + +G T NN ++I
Sbjct: 333 SYVYSSPRHEDLSLNNTH--------VGSTHANNGKPTDATSI 367
>YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 655
Score = 146 bits (369), Expect = 1e-34
Identities = 93/277 (33%), Positives = 143/277 (51%), Gaps = 32/277 (11%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQV-----------------YAIKVLNLDNTEDEVED 58
F+ E G+G G VY + +K Q AIK + L + + +
Sbjct: 360 FQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSE-QPKKQL 418
Query: 59 IRKEIQFLSSLKQTPNITHYYGSYLIDTK-LWVIMEYCAGGSLRTLL----------RPG 107
I E+ ++ +Q NI ++ +Y+ID + LWVIMEY GG L +L
Sbjct: 419 IMNELLVMNDSRQE-NIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSS 477
Query: 108 IIEEKYIGVIMREILVALISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSML 167
+ E + I++E L +H +IHRDIK+ NIL+ + G VK+ DFG +L++
Sbjct: 478 PLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRS 537
Query: 168 KRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITK 227
KR TM GTPYWMAPE++ + YD KVD+WSLGI E+ G PPY + + ++A+ +I
Sbjct: 538 KRATMVGTPYWMAPEIVNQ-KGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIAN 596
Query: 228 SKPPRLEGRE-YSQPLKEFIALCLDEDPKERPYAEEL 263
+ P+L E S+ K+F+ CL + + R +L
Sbjct: 597 NGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKL 633
>At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 356
Score = 145 bits (366), Expect = 3e-34
Identities = 85/261 (32%), Positives = 143/261 (54%), Gaps = 10/261 (3%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
++IG+G GVV H + +A+KV+ ++ E+ + I +E++ + Q P++ Y
Sbjct: 74 KVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQASSQCPHVVVCY 133
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRD-NVIHRD 137
S+ + +++EY GSL ++R I E Y+ V+ +++L+ L+ +H + +VIHRD
Sbjct: 134 HSFYHNGAFSLVLEYMDRGSLADVIRQVKTILEPYLAVVCKQVLLGLVYLHNERHVIHRD 193
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIW 197
IK +N+L+ + G VK+ DFGV+A L+ SM +R T GT +M+PE I G YD DIW
Sbjct: 194 IKPSNLLVNHKGEVKISDFGVSASLASSMGQRDTFVGTYNYMSPERI-SGSTYDYSSDIW 252
Query: 198 SLGITAYEIATGNPPYCHME-------AIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
SLG++ E A G PY E + I ++ PP ++S F++ C+
Sbjct: 253 SLGMSVLECAIGRFPYLESEDQQNPPSFYELLAAIVENPPPTAPSDQFSPEFCSFVSACI 312
Query: 251 DEDPKERPYAEELFKSKLIKQ 271
+DP R + +L IK+
Sbjct: 313 QKDPPARASSLDLLSHPFIKK 333
>Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 438
Score = 145 bits (365), Expect = 4e-34
Identities = 90/277 (32%), Positives = 143/277 (51%), Gaps = 10/277 (3%)
Query: 19 KEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
++ +G G G VYKA+HV + ++ A+KV+ LD T + + I E++ L + I +
Sbjct: 169 RDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSS-YIIGF 227
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
YG++ ++ ++ + E+ GGSL + + E +G I ++ L + ++HRD+
Sbjct: 228 YGAFFVENRISICTEFMDGGSLDVYRK---MPEHVLGRIAVAVVKGLTYLWSLKILHRDV 284
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K +N+L+ G VKLCDFGV+ QL S+ K T GT +MAPE I G Y D+WS
Sbjct: 285 KPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERI-SGEQYGIHSDVWS 341
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERP 258
LGI+ EI + ++ +Q I P L E+S+P FI C+ + PKERP
Sbjct: 342 LGISFMEIQKNQG---SLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERP 398
Query: 259 YAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNE 295
EEL I Q + ++ + R L R +
Sbjct: 399 APEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQ 435
>Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 1315
Score = 145 bits (365), Expect = 4e-34
Identities = 81/239 (33%), Positives = 131/239 (53%), Gaps = 5/239 (2%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVL-NLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
E+IG G FG VYK + QV A+K + L +E E+ ++++EI+ + L+ PNI H
Sbjct: 8 EMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH-PNIVHM 66
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
S+ D ++ V+ +Y G + L G + E + I +++ AL +H ++HRD+
Sbjct: 67 LDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDM 126
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K NIL+A G +KLCDFG A +S + + ++ GTP +M+PE++ E YD D+WS
Sbjct: 127 KPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERP-YDHTADLWS 185
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKER 257
+G YE+A G PP+ + + +I K P S K F+ L +DP++R
Sbjct: 186 VGCILYELAVGTPPFYATSIFQLVSLILKD--PVRWPSTISPCFKNFLQGLLTKDPRQR 242
>Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 467
Score = 144 bits (364), Expect = 5e-34
Identities = 89/270 (32%), Positives = 141/270 (51%), Gaps = 10/270 (3%)
Query: 19 KEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
++ +G G G VYKA+HV + ++ A+KV+ LD T + + I E++ L + I +
Sbjct: 169 RDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSS-YIIGF 227
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
YG++ ++ ++ + E+ GGSL + + E +G I ++ L + ++HRD+
Sbjct: 228 YGAFFVENRISICTEFMDGGSLDVYRK---MPEHVLGRIAVAVVKGLTYLWSLKILHRDV 284
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K +N+L+ G VKLCDFGV+ QL S+ K T GT +MAPE I G Y D+WS
Sbjct: 285 KPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERI-SGEQYGIHSDVWS 341
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERP 258
LGI+ EI + ++ +Q I P L E+S+P FI C+ + PKERP
Sbjct: 342 LGISFMEIQKNQG---SLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERP 398
Query: 259 YAEELFKSKLIKQEKGTSTVILKELITRYL 288
EEL I Q + ++ + R L
Sbjct: 399 APEELMGHPFIVQFNDGNAAVVSMWVCRAL 428
>At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 354
Score = 144 bits (363), Expect = 7e-34
Identities = 90/267 (33%), Positives = 140/267 (51%), Gaps = 11/267 (4%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
++IG+G G V H TQQ +A+KV+ L+ E I +E++ S Q P + Y
Sbjct: 72 KVIGKGSSGNVQLVKHKLTQQFFALKVIQLNTEESTCRAISQELRINLS-SQCPYLVSCY 130
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDN-VIHRD 137
S+ + + +I+E+ GGSL LL+ G + E + I + +L L IH + +IHRD
Sbjct: 131 QSFYHNGLVSIILEFMDGGSLADLLKKVGKVPENMLSAICKRVLRGLCYIHHERRIIHRD 190
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIW 197
+K +N+LI + G VK+ DFGV+ L+ + + GT +M+PE I G Y K DIW
Sbjct: 191 LKPSNLLINHRGEVKITDFGVSKILTSTSSLANSFVGTYPYMSPERI-SGSLYSNKSDIW 249
Query: 198 SLGITAYEIATGNPPYCHME-------AIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
SLG+ E ATG PY E + I ++ PP +S FI+ C+
Sbjct: 250 SLGLVLLECATGKFPYTPPEHKKGWSSVYELVDAIVENPPPCAPSNLFSPEFCSFISQCV 309
Query: 251 DEDPKERPYAEELFKSKLIKQEKGTST 277
+DP++R A+EL + K +K + + T
Sbjct: 310 QKDPRDRKSAKELLEHKFVKMFEDSDT 336
>YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 508
Score = 142 bits (359), Expect = 2e-33
Identities = 100/269 (37%), Positives = 138/269 (51%), Gaps = 24/269 (8%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVE-DIRKEIQFLSSLKQTPNITHYY 79
I+G G G V K +++A+KV+N NT+ E + I +E+QF S Q+ I YY
Sbjct: 226 ILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSF-QSEYIVRYY 284
Query: 80 GSYLID--TKLWVIMEYCAGGSL-----RTLLRPGIIEEKYIGVIMREILVALISIHRDN 132
G + D + +++ MEY G SL L R G I EK +G I +L L +H
Sbjct: 285 GMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKK 344
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
VIHRDIK NIL+ NG VKLCDFGV+ + S+ T GT ++MAPE I +G Y
Sbjct: 345 VIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSL--ATTFTGTSFYMAPERI-QGQPYSV 401
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAIRA------MQMITKSKPPRLEGRE-----YSQP 241
D+WSLG+T E+A G P C E + A + M + P L+ +S
Sbjct: 402 TSDVWSLGLTILEVANGKFP-CSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPS 460
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIK 270
K FI CL +D +ERP ++ IK
Sbjct: 461 FKSFIDYCLKKDSRERPSPRQMINHPWIK 489
>At4g08500 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 142 bits (359), Expect = 2e-33
Identities = 90/262 (34%), Positives = 141/262 (53%), Gaps = 11/262 (4%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNL----DNTEDEVEDIRKEIQFLSSLKQ 71
+++ +++GRG FG VY+ +A+K ++L ++ ++ + EI+ LS L Q
Sbjct: 333 WQKGQLLGRGSFGSVYEGIS-GDGDFFAVKEVSLLDQGSQAQECIQQLEGEIKLLSQL-Q 390
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRD 131
NI Y G+ + L++ +E GSL L + + + + + R+IL L +H
Sbjct: 391 HQNIVRYRGTAKDGSNLYIFLELVTQGSLLKLYQRYQLRDSVVSLYTRQILDGLKYLHDK 450
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVY 189
IHRDIK ANIL+ NG+VKL DFG+A + +K + GTP+WMAPEVI +
Sbjct: 451 GFIHRDIKCANILVDANGAVKLADFGLAKVSKFNDIK--SCKGTPFWMAPEVINRKDSDG 508
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALC 249
Y + DIWSLG T E+ TG PY +E ++A+ I + P + S + FI C
Sbjct: 509 YGSPADIWSLGCTVLEMCTGQIPYSDLEPVQALFRIGRGTLPEVPD-TLSLDARLFILKC 567
Query: 250 LDEDPKERPYAEELFKSKLIKQ 271
L +P+ERP A EL +++
Sbjct: 568 LKVNPEERPTAAELLNHPFVRR 589
>YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 506
Score = 140 bits (354), Expect = 8e-33
Identities = 94/263 (35%), Positives = 137/263 (51%), Gaps = 22/263 (8%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVE-DIRKEIQFLSSLKQTPNITHYY 79
I+G G G V K ++V+A+K +N NT+ E + I +E+QF S K + I YY
Sbjct: 219 ILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFK-SDYIVQYY 277
Query: 80 GSYLID--TKLWVIMEYCAGGSLRT-----LLRPGIIEEKYIGVIMREILVALISIHRDN 132
G + + + +++ MEY G SL L R G I E+ IG I +L L +H
Sbjct: 278 GMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERK 337
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
VIHRDIK NIL+ G +KLCDFGV+ + S+ T GT ++MAPE I +G Y
Sbjct: 338 VIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSL--AMTFTGTSFYMAPERI-QGQPYSV 394
Query: 193 KVDIWSLGITAYEIATGNPPY------CHMEAIRAMQMITKSKPPRLEGRE----YSQPL 242
D+WSLG+T E+A G P+ ++ I + MI P + E +S+
Sbjct: 395 TCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTF 454
Query: 243 KEFIALCLDEDPKERPYAEELFK 265
+ FI CL +D +ERP ++ K
Sbjct: 455 RSFIDYCLKKDARERPSPRQMLK 477
>YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 668
Score = 140 bits (353), Expect = 1e-32
Identities = 98/291 (33%), Positives = 147/291 (49%), Gaps = 20/291 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G V K H T + A K + L+ E + I E++ L +P I +YG+
Sbjct: 366 LGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCN-SPYIVDFYGA 424
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRP----GIIEEKYIGVIMREILVALISI-HRDNVIHR 136
+ I+ +++ MEY GGSL + G I+E + I ++ L + + N+IHR
Sbjct: 425 FFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEPQLAFIANAVIHGLKELKEQHNIIHR 484
Query: 137 DIKAANILI-ANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM----EGVYYD 191
D+K NIL AN G+VKLCDFGV+ L S+ K T G +MAPE I + Y
Sbjct: 485 DVKPTNILCSANQGTVKLCDFGVSGNLVASLAK--TNIGCQSYMAPERIKSLNPDRATYT 542
Query: 192 TKVDIWSLGITAYEIATGN---PPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL 248
+ DIWSLG++ E+A G PP + + I PPRL ++S ++F++L
Sbjct: 543 VQSDIWSLGLSILEMALGRYPYPPETYDNIFSQLSAIVDGPPPRLPSDKFSSDAQDFVSL 602
Query: 249 CLDEDPKERP-YA---EELFKSKLIKQEKGTSTVILKELITRYLLFREKNE 295
CL + P+ RP YA E + K Q+ S I + L R + RE+ E
Sbjct: 603 CLQKIPERRPTYAALTEHPWLVKYRNQDVHMSEYITERLERRNKILRERGE 653
>Hs4506889 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 399
Score = 139 bits (351), Expect = 2e-32
Identities = 88/261 (33%), Positives = 134/261 (50%), Gaps = 14/261 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IGRG +G V K H + Q+ A+K + E E + + ++ + P I +YG+
Sbjct: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
Query: 82 YLIDTKLWVIMEYCAGGSLRTL-----LRPGIIEEKYIGVIMREILVALISIHRD-NVIH 135
+ W+ ME + + + +I E+ +G I + AL + + +IH
Sbjct: 168 LFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIH 227
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY---YDT 192
RDIK +NIL+ +G++KLCDFG++ QL S+ K + PY MAPE I YD
Sbjct: 228 RDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY-MAPERIDPSASRQGYDV 286
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAI-RAMQMITKSKPPRL---EGREYSQPLKEFIAL 248
+ D+WSLGIT YE+ATG PY ++ + + K PP+L E RE+S F+ L
Sbjct: 287 RSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNL 346
Query: 249 CLDEDPKERPYAEELFKSKLI 269
CL +D +RP +EL K I
Sbjct: 347 CLTKDESKRPKYKELLKHPFI 367
>SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 605
Score = 139 bits (350), Expect = 2e-32
Identities = 86/254 (33%), Positives = 131/254 (50%), Gaps = 14/254 (5%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
E +G+G +GVVYKA H T A+K + L E I E+ L +P I +Y
Sbjct: 324 EELGKGNYGVVYKALHQPTGVTMALKEIRLSLEEATFNQIIMELDILHKAV-SPYIVDFY 382
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRD-NVIHRDI 138
G++ ++ +++ MEY GS+ L GI +E + ++ L ++ + N+IHRD+
Sbjct: 383 GAFFVEGSVFICMEYMDAGSMDKLYAGGIKDEGVLARTAYAVVQGLKTLKEEHNIIHRDV 442
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEG------VYYDT 192
K N+L+ +NG VKLCDFGV+ L S+ K T G +MAPE I G + Y
Sbjct: 443 KPTNVLVNSNGQVKLCDFGVSGNLVASISK--TNIGCQSYMAPERIRVGGPTNGVLTYTV 500
Query: 193 KVDIWSLGITAYEIATG---NPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALC 249
+ D+WSLG+T E+A G PP + + I PP L +S ++F+ C
Sbjct: 501 QADVWSLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPPSLPD-SFSPEARDFVNKC 559
Query: 250 LDEDPKERPYAEEL 263
L+++P RP EL
Sbjct: 560 LNKNPSLRPDYHEL 573
>YJL095w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1478
Score = 139 bits (349), Expect = 3e-32
Identities = 89/257 (34%), Positives = 135/257 (51%), Gaps = 14/257 (5%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE-------VEDIRKEIQFLSSLKQT 72
E+IG+G FG VY +V T ++ A+K + + + VE +R E+ L L
Sbjct: 1179 EMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHL 1238
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRD 131
NI Y G + + +EY AGGS+ +L+R G +E I + ++L L +H
Sbjct: 1239 -NIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSK 1297
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQ-TMAGTPYWMAPEVIMEGVYY 190
++HRD+KA N+L+ +G K+ DFG++ + TM GT +WMAPE++ Y
Sbjct: 1298 GILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGY 1357
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSK--PPRLEGR--EYSQPLKEFI 246
KVDIWSLG E+ G P+ ++E + AM I KSK PP E SQ + F+
Sbjct: 1358 SAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFL 1417
Query: 247 ALCLDEDPKERPYAEEL 263
C + +P++RP A EL
Sbjct: 1418 DACFEINPEKRPTANEL 1434
>Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 626
Score = 139 bits (349), Expect = 3e-32
Identities = 95/259 (36%), Positives = 141/259 (53%), Gaps = 15/259 (5%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLD----NTEDEVEDIRKEIQFLSSLKQ 71
++R +++G+G FG VY + V T + A K + D T EV + EIQ L +L Q
Sbjct: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL-Q 420
Query: 72 TPNITHYYGSYL--IDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISI 128
I YYG + L + MEY GGS++ L+ G + E R+IL + +
Sbjct: 421 HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL 480
Query: 129 HRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLS---QSMLKRQTMAGTPYWMAPEVIM 185
H + ++HRDIK ANIL + G+VKL DFG + +L S +++ GTPYWM+PEVI
Sbjct: 481 HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI- 539
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAM-QMITKSKPPRLEGREYSQPLKE 244
G Y K D+WSLG T E+ T PP+ EA+ A+ ++ T+ P+L S+ ++
Sbjct: 540 SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPS-HISEHGRD 598
Query: 245 FIALCLDEDPKERPYAEEL 263
F+ E ++RP AEEL
Sbjct: 599 FLRRIFVE-ARQRPSAEEL 616
>SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1401
Score = 137 bits (346), Expect = 7e-32
Identities = 101/346 (29%), Positives = 167/346 (48%), Gaps = 26/346 (7%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTE---DEVEDIRKEIQFLSSLKQT 72
+++ + G FG VY +++T + A+K + L ++ V+ I E+ L L
Sbjct: 1037 WQQGHFVRSGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNH- 1095
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIE-EKYIGVIMREILVALISIHRD 131
PN+ YYG + K+++ ME+C GGSL LL G IE E + V + ++L L IH
Sbjct: 1096 PNVVTYYGVEVHREKVYIFMEFCQGGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQ 1155
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLS----------QSMLKRQTMAGTPYWMAP 181
+++HRDIK ANIL+ + G +K DFG A +S + Q +AGTP +MAP
Sbjct: 1156 HILHRDIKPANILLDHRGMIKYSDFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAP 1215
Query: 182 EVIMEGVYYD-TKVDIWSLGITAYEIATGNPPYCHMEAIRAM--QMITKSKPPRLEGREY 238
E+I+ D +DIWSLG E+ TG+ P+ M+ A+ + P + +
Sbjct: 1216 EIILGTKKGDFGAMDIWSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKI 1275
Query: 239 SQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV------ILKELITRYLLFRE 292
S ++FI C + DP++RP A +L I + + + I K+ + + E
Sbjct: 1276 SSLARDFIEQCFERDPEQRPRAVDLLTHPWITDFRKKTIITMPPATITKKTSLSHTITEE 1335
Query: 293 KNEQY--KHEEESHTSSKQNPNSSIEGNASQDAGSFTEKEPEDIDI 336
K Q ++S + S E +A A + ++P ++ I
Sbjct: 1336 KTAQLLAGRHDDSKAETDSLAASYKEESALPVASNVGLRQPNELRI 1381
>SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1116
Score = 137 bits (346), Expect = 7e-32
Identities = 91/269 (33%), Positives = 141/269 (51%), Gaps = 20/269 (7%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT---------EDEVEDIRKEIQFLSSLK 70
E+IG G +G V+ A ++ T ++ A+K + + T +D V+ I EI ++ L
Sbjct: 829 ELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAEISMIADLD 888
Query: 71 QTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIH 129
NI Y G +T + + +EY +GGS+ LR G EE+ + + R++L L +H
Sbjct: 889 HL-NIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYGPFEEQLVRFVSRQVLYGLSYLH 947
Query: 130 RDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQ---TMAGTPYWMAPEVI-M 185
+IHRD+KA N+LI +G K+ DFG++ S ++ +M G+ +WMAPEVI
Sbjct: 948 SKGIIHRDLKADNLLIDFDGVCKISDFGISKH-SDNVYDNDANLSMQGSIFWMAPEVIHN 1006
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAM-QMITKSKPPRLEGREYSQPLKE 244
+ Y KVD+WSLG E+ G P+ EAI+AM ++ T+ K P + SQ E
Sbjct: 1007 DHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGTEKKAPPIPSELVSQVSPE 1066
Query: 245 ---FIALCLDEDPKERPYAEELFKSKLIK 270
F+ C + RP AEEL +K
Sbjct: 1067 AIQFLNACFTVNADVRPTAEELLNHPFMK 1095
>7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 396
Score = 137 bits (345), Expect = 9e-32
Identities = 95/279 (34%), Positives = 147/279 (52%), Gaps = 34/279 (12%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G GVV K H T + A K+++L+ + I +E++ L P+I +YG+
Sbjct: 93 LGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECN-FPHIVGFYGA 151
Query: 82 YLIDTKLWVIMEYCAGGSLRTLL-RPGIIEEKYIGVIMREILVALISIHRDN--VIHRDI 138
+ D ++ + MEY GGSL +L R G I E +G I +L L S RDN +IHRD+
Sbjct: 152 FYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGL-SYLRDNHAIIHRDV 210
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K +NIL+ ++G +K+CDFGV+ QL SM + GT +M+PE ++G +Y + DIWS
Sbjct: 211 KPSNILVNSSGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPE-RLQGTHYSVQSDIWS 267
Query: 199 LGITAYEIATG-----NPPYCHMEAI---------------RAMQM------ITKSKPPR 232
LG++ E+A G P +E+I RAM + I PP+
Sbjct: 268 LGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPK 327
Query: 233 LEGREYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQ 271
LE + +S K+F+ +CL + P ER + L I++
Sbjct: 328 LEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRK 366
>7292830 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 334
Score = 135 bits (340), Expect = 3e-31
Identities = 89/276 (32%), Positives = 135/276 (48%), Gaps = 11/276 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+GRG +G+V K H +T V A+K + + E + ++ P H+YG+
Sbjct: 52 LGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGA 111
Query: 82 YLIDTKLWVIMEYCAGGS----LRTLLRPGIIEEKYIGVIMREILVALISIHRD-NVIHR 136
+ +W+ ME + + L +EE +G I ++ AL +H VIHR
Sbjct: 112 MYREGDVWICMEVMSTSLDKFYPKVFLHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHR 171
Query: 137 DIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI---MEGVYYDTK 193
D+K +NILI G VK+CDFG++ L S+ K PY MAPE I YD +
Sbjct: 172 DVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPY-MAPERIDPQGNPAQYDIR 230
Query: 194 VDIWSLGITAYEIATGNPPYCHMEA-IRAMQMITKSKPPRLEGREYSQPLKEFIALCLDE 252
D+WSLGI E+ATG PY + ++ + + PPRL +S ++FIA+CL +
Sbjct: 231 SDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQK 290
Query: 253 DPKERPYAEELFKSKLIKQEKGTSTVILKELITRYL 288
+ RP E+L K I + +T I E + R L
Sbjct: 291 EYMARPNYEQLLKHSFIVEHLQRNTDI-SEFVARIL 325
>Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase
Length = 330
Score = 135 bits (339), Expect = 4e-31
Identities = 78/258 (30%), Positives = 141/258 (54%), Gaps = 7/258 (2%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDN-TEDEVEDIRKEIQFLSSLKQTPNITHYY 79
++GRG FG + + K ++L +E E D EI L+ L Q NI YY
Sbjct: 57 VLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALL-QHDNIIAYY 115
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLL---RPGIIEEKYIGVIMREILVALISIHRDNVIHR 136
++ +T L + +EYC GG+L + + + EE+ + + +I+ A+ IH+ ++HR
Sbjct: 116 NHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHR 175
Query: 137 DIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDI 196
DIK NI + +KL D+G+A +L+ +T+ GTPY+M+PE + +GV Y+ K DI
Sbjct: 176 DIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPE-LCQGVKYNFKSDI 234
Query: 197 WSLGITAYEIATGNPPYCHMEAIR-AMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPK 255
W++G +E+ T + + ++++ + ++ +YS L + + CLD+DP+
Sbjct: 235 WAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPE 294
Query: 256 ERPYAEELFKSKLIKQEK 273
+RP A+EL L+++ +
Sbjct: 295 QRPTADELLDRPLLRKRR 312
>At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 422
Score = 135 bits (339), Expect = 4e-31
Identities = 90/263 (34%), Positives = 135/263 (51%), Gaps = 20/263 (7%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNL----DNTEDEVEDIRKEIQFLSSLKQ 71
+++ +++GRG G VY+ +A K ++L + ++ + I LS L Q
Sbjct: 153 WQKGQLLGRGSLGSVYEGISADGD-FFAFKEVSLLDQGSQAHEWIQQVEGGIALLSQL-Q 210
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRD 131
NI Y G+ ++ L++ +E GSLR L + + + + + R+IL L +H
Sbjct: 211 HQNIVRYRGTTKDESNLYIFLELVTQGSLRKLYQRNQLGDSVVSLYTRQILDGLKYLHDK 270
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPY--WMAPEVIMEGVY 189
IHR+IK AN+L+ NG+VKL DFG+A K ++ TPY WMAPEVI+
Sbjct: 271 GFIHRNIKCANVLVDANGTVKLADFGLA--------KVMSLWRTPYWNWMAPEVILNPKD 322
Query: 190 YD---TKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFI 246
YD T DIWSLG T E+ TG PY +E A+ I K P++ S ++FI
Sbjct: 323 YDGYGTPADIWSLGCTVLEMLTGQIPYSDLEIGTALYNIGTGKLPKIPD-ILSLDARDFI 381
Query: 247 ALCLDEDPKERPYAEELFKSKLI 269
CL +P+ERP A EL +
Sbjct: 382 LTCLKVNPEERPTAAELLNHPFV 404
>Hs5453882 [G] KOG0599 Phosphorylase kinase gamma subunit
Length = 387
Score = 134 bits (338), Expect = 6e-31
Identities = 84/272 (30%), Positives = 142/272 (51%), Gaps = 17/272 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDN----TEDEVEDIR----KEIQFLS 67
++ KEI+GRG VV + H T Q YA+KV+++ + +EV ++R KE+ L
Sbjct: 20 YEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILR 79
Query: 68 SLKQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALI 126
+ PNI +Y +T +++ + G L L + + EK IMR +L +
Sbjct: 80 KVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVIC 139
Query: 127 SIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI-- 184
++H+ N++HRD+K NIL+ +N ++KL DFG + QL R+ + GTP ++APE+I
Sbjct: 140 TLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLRE-VCGTPSYLAPEIIEC 198
Query: 185 ---MEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPP--RLEGREYS 239
+ Y +VD+WS G+ Y + G+PP+ H + + ++MI E +YS
Sbjct: 199 SMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYS 258
Query: 240 QPLKEFIALCLDEDPKERPYAEELFKSKLIKQ 271
+K+ ++ L P+ R AEE +Q
Sbjct: 259 DTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQ 290
>CE10328 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 363
Score = 134 bits (338), Expect = 6e-31
Identities = 87/255 (34%), Positives = 131/255 (51%), Gaps = 15/255 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTPNITHYY 79
IG G FG VYK H +T ++ A+K + +N +++ +R+ + S K PNI +Y
Sbjct: 72 IGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIRLLREHDTIVKSEKG-PNIVKFY 130
Query: 80 GSYLIDTKLWVIMEYCAGG-----SLRTLLRPGIIEEKYIGVIMREILVALISIHRD-NV 133
G+ + W+ ME +++ + E +G I + AL + ++ +
Sbjct: 131 GAIFSEGDCWICMELMDISMDLLYKRVYMVKNSRLNENVVGHITVCTVDALDYLKKELKI 190
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
IHRD+K +NIL+ G+VKLCDFG+ QL +S K PY +APE I YD +
Sbjct: 191 IHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPY-LAPERITSSDKYDVR 249
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAI-RAMQMITKSKPPRL----EGREYSQPLKEFIAL 248
D+WSLGIT YEIATG PY ++ + + PP L + YS PL +FI
Sbjct: 250 SDVWSLGITLYEIATGKFPYQEWNSLFDQIATVVSGDPPILHPDSDDFHYSLPLVKFINT 309
Query: 249 CLDEDPKERPYAEEL 263
CL +D + RP + L
Sbjct: 310 CLTKDRRHRPKYDTL 324
>Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 313
Score = 134 bits (336), Expect = 9e-31
Identities = 85/252 (33%), Positives = 130/252 (50%), Gaps = 11/252 (4%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEV--EDIRKEIQFLSSLKQTP 73
F+ ++ IGRG+F VYKA + ++ A+K + + D +D KEI L L P
Sbjct: 45 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNH-P 103
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTLLR-----PGIIEEKYIGVIMREILVALISI 128
NI Y S++ D +L +++E G L +++ +I E+ + ++ A+ +
Sbjct: 104 NIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHM 163
Query: 129 HRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGV 188
H V+HRDIK AN+ I G VKL D G+ S ++ GTPY+M+PE I E
Sbjct: 164 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHEN- 222
Query: 189 YYDTKVDIWSLGITAYEIATGNPPYC--HMEAIRAMQMITKSKPPRLEGREYSQPLKEFI 246
Y+ K DIWSLG YE+A P+ M Q I + P L G YS+ L+E +
Sbjct: 223 GYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELV 282
Query: 247 ALCLDEDPKERP 258
++C+ DP +RP
Sbjct: 283 SMCICPDPHQRP 294
>Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1050
Score = 133 bits (335), Expect = 1e-30
Identities = 89/262 (33%), Positives = 134/262 (50%), Gaps = 17/262 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQV-YAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
F RK++IG G F VV+K H + + A+K +N N + KEI+ L LK N
Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHE-N 74
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNV 133
I Y + ++++MEYC GG L L + E I + +++I A+ +H +
Sbjct: 75 IVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGI 134
Query: 134 IHRDIKAANILIANNGS---------VKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI 184
IHRD+K NIL++N VK+ DFG A L QS + T+ G+P +MAPEVI
Sbjct: 135 IHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYL-QSNMMAATLCGSPMYMAPEVI 193
Query: 185 MEGVYYDTKVDIWSLGITAYEIATGNPPY--CHMEAIRAMQMITKSKPPRLEGREYSQPL 242
M +YD K D+WS+G Y+ TG P+ + +R K+ P + RE S PL
Sbjct: 194 M-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIP-RETSAPL 251
Query: 243 KEFIALCLDEDPKERPYAEELF 264
++ + L + K+R +E F
Sbjct: 252 RQLLLALLQRNHKDRMDFDEFF 273
>At4g08480 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 773
Score = 133 bits (335), Expect = 1e-30
Identities = 87/264 (32%), Positives = 141/264 (52%), Gaps = 15/264 (5%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNL----DNTEDEVEDIRKEIQFLSSLKQ 71
+++ +++ +G FG VY+A + +A+K ++L ++ ++ + EI LS L+
Sbjct: 501 WQKGQLLRQGSFGSVYEAIS-EDGDFFAVKEVSLLDQGSQAQECIQQLEGEIALLSQLEH 559
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRD 131
NI Y G+ + L++ +E GSL L R I + I + ++IL L +H
Sbjct: 560 Q-NILRYRGTDKDGSNLYIFLELVTQGSLLELYRRYQIRDSLISLYTKQILDGLKYLHHK 618
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVA--AQLSQSMLKRQTMAGTPYWMAPEVI--MEG 187
IHRDIK A IL+ NG+VKL DFG+A ++L+ +++T+ +WMAPEVI +
Sbjct: 619 GFIHRDIKCATILVDANGTVKLADFGLAKVSKLNDIKSRKETL----FWMAPEVINRKDN 674
Query: 188 VYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIA 247
Y + DIWSLG T E+ TG PY +E + A+ I + P + S + FI
Sbjct: 675 DGYRSPADIWSLGCTVLEMCTGQIPYSDLEPVEALFRIRRGTLPEVPD-TLSLDARHFIL 733
Query: 248 LCLDEDPKERPYAEELFKSKLIKQ 271
CL +P+ERP A EL +++
Sbjct: 734 KCLKLNPEERPTATELLNHPFVRR 757
>Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1558
Score = 132 bits (332), Expect = 3e-30
Identities = 88/269 (32%), Positives = 140/269 (51%), Gaps = 23/269 (8%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLD-NTEDEVEDIRKEIQFLSSLKQTPN 74
++R IG G++G VY V T ++ A+K + N +++ E++ +K PN
Sbjct: 1293 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKH-PN 1351
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+ Y+G L ++++ MEYC G+L + R G+ +E I + ++I +A+ +H ++
Sbjct: 1352 LVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGL-QEHVIRLYSKQITIAINVLHEHGIV 1410
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTM-------AGTPYWMAPEVI--M 185
HRDIK ANI + ++G +KL DFG + +L + QTM GT +MAPEVI
Sbjct: 1411 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNN---AQTMPGEVNSTLGTAAYMAPEVITRA 1467
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITK----SKPPRLEGREYSQP 241
+G + DIWSLG E+ TG P+ E Q++ K KPP E S
Sbjct: 1468 KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYE--HNFQIMYKVGMGHKPPIPE--RLSPE 1523
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIK 270
K+F++ CL+ DPK R A +L +K
Sbjct: 1524 GKDFLSHCLESDPKMRWTASQLLDHSFVK 1552
>Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1607
Score = 132 bits (332), Expect = 3e-30
Identities = 88/269 (32%), Positives = 140/269 (51%), Gaps = 23/269 (8%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLD-NTEDEVEDIRKEIQFLSSLKQTPN 74
++R IG G++G VY V T ++ A+K + N +++ E++ +K PN
Sbjct: 1342 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKH-PN 1400
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+ Y+G L ++++ MEYC G+L + R G+ +E I + ++I +A+ +H ++
Sbjct: 1401 LVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGL-QEHVIRLYSKQITIAINVLHEHGIV 1459
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTM-------AGTPYWMAPEVI--M 185
HRDIK ANI + ++G +KL DFG + +L + QTM GT +MAPEVI
Sbjct: 1460 HRDIKGANIFLTSSGLIKLGDFGCSVKLKNN---AQTMPGEVNSTLGTAAYMAPEVITRA 1516
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITK----SKPPRLEGREYSQP 241
+G + DIWSLG E+ TG P+ E Q++ K KPP E S
Sbjct: 1517 KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYE--HNFQIMYKVGMGHKPPIPE--RLSPE 1572
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIK 270
K+F++ CL+ DPK R A +L +K
Sbjct: 1573 GKDFLSHCLESDPKMRWTASQLLDHSFVK 1601
>At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 269
Score = 131 bits (330), Expect = 5e-30
Identities = 79/239 (33%), Positives = 125/239 (52%), Gaps = 5/239 (2%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIK-VLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
E++G G FG VYK T Q A+K ++ T+ ++ +R+EI+ L LK NI
Sbjct: 10 ELVGEGSFGRVYKGRRKYTGQTVAMKFIMKQGKTDKDIHSLRQEIEILRKLKHE-NIIEM 68
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
S+ + V+ E+ G L + E+ + I ++++ AL +H + +IHRD+
Sbjct: 69 LDSFENAREFCVVTEFAQGELFEILEDDKCLPEEQVQAIAKQLVKALDYLHSNRIIHRDM 128
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K NILI VKLCDFG A +S + + +++ GTP +MAPE++ E YD VD+WS
Sbjct: 129 KPQNILIGAGSVVKLCDFGFARAMSTNTVVLRSIKGTPLYMAPELVKEQP-YDRTVDLWS 187
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKER 257
LG+ YE+ G PP+ ++ I K P E S + F+ L+++P R
Sbjct: 188 LGVILYELYVGQPPFYTNSVYALIRHIVKD--PVKYPDEMSTYFESFLKGLLNKEPHSR 244
>YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1331
Score = 131 bits (329), Expect = 6e-30
Identities = 89/272 (32%), Positives = 139/272 (50%), Gaps = 25/272 (9%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTED--EVEDIRKEIQFLSSLKQTP 73
++++ IG G FG VY A +++ ++ A+K + + +T ++ + KE + + P
Sbjct: 1034 WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHP 1093
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMR-EILVALISIHRDN 132
NI YYG + K+ + MEYC GGSL +LL G IE++ + + E+L L +H+
Sbjct: 1094 NIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSG 1153
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKR----------------QTMAGTP 176
V+HRDIK NIL+ NG +K DFG A + S + M GTP
Sbjct: 1154 VVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTP 1213
Query: 177 YWMAPEVIMEGVYYDTKV---DIWSLGITAYEIATGNPPYCHMEAIRA-MQMITKSKPPR 232
+MAPE I G K+ D+W+LG E+ATG P+ +++ A M + + P+
Sbjct: 1214 MYMAPETI-SGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQ 1272
Query: 233 LEGR-EYSQPLKEFIALCLDEDPKERPYAEEL 263
L R E + + F+ CL +DP R A EL
Sbjct: 1273 LPNRDEMTAAGRAFLERCLVQDPTMRATAVEL 1304
>HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 618
Score = 130 bits (326), Expect = 1e-29
Identities = 91/261 (34%), Positives = 136/261 (51%), Gaps = 15/261 (5%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLD----NTEDEVEDIRKEIQFLSSLKQTPNI 75
+++G+G FG VY + V T + A+K + D T EV + EIQ L + I
Sbjct: 359 KLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNFLHE-RI 417
Query: 76 THYYGSYLI--DTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDN 132
YYG + L + MEY GGS++ L+ G + E R+IL + +H +
Sbjct: 418 VQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTRQILEGVHYLHSNM 477
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLK---RQTMAGTPYWMAPEVIMEGVY 189
++HRDIK ANIL + G+VKL DFG + +L L +++ GTPYWM+PEVI G
Sbjct: 478 ILHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI-SGQG 536
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAM-QMITKSKPPRLEGREYSQPLKEFIAL 248
Y K DIWS+ T E+ T PP+ EA+ A+ ++ T+ P+L S ++F+
Sbjct: 537 YGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLP-PHVSDYTRDFLKR 595
Query: 249 CLDEDPKERPYAEELFKSKLI 269
E K RP A+EL + +
Sbjct: 596 IFVE-AKLRPSADELLRHMFV 615
>Hs20547806 [R] KOG0589 Serine/threonine protein kinase
Length = 489
Score = 130 bits (326), Expect = 1e-29
Identities = 97/316 (30%), Positives = 146/316 (45%), Gaps = 20/316 (6%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
+IG G FG H + Q++A+K + L + ++ RKE L+ +K PNI +
Sbjct: 9 MIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKH-PNIVAFKE 67
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLLRPG---IIEEKYIGVIMREILVALISIHRDNVIHRD 137
S+ + L+++MEYC GG L ++ + E I ++ + + IH+ V+HRD
Sbjct: 68 SFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRD 127
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIW 197
IK+ NI + NG VKL DFG A LS M T GTPY++ PE I E + Y+ K DIW
Sbjct: 128 IKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPE-IWENLPYNNKSDIW 186
Query: 198 SLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE--GREYSQPLKEFIALCLDEDPK 255
SLG YE+ T P+ +A +I K + YS L+ + +P
Sbjct: 187 SLGCILYELCTLKHPF---QANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPS 243
Query: 256 ERPYAEELFKSKLIKQEKGTSTVILKELITRY---LLFREKNEQY-----KHEEESHTSS 307
RP A L ++ + + E+I Y +L KN ++ K EEE
Sbjct: 244 HRPSATTLLSRGIV--ARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKQEEEQDRKG 301
Query: 308 KQNPNSSIEGNASQDA 323
SI N + A
Sbjct: 302 SHTDLESINENLVESA 317
>Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 445
Score = 129 bits (325), Expect = 2e-29
Identities = 97/322 (30%), Positives = 149/322 (46%), Gaps = 37/322 (11%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN-TEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
IG G +G K ++ K L+ + TE E + + E+ L LK PNI YY
Sbjct: 14 IGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH-PNIVRYYD 72
Query: 81 SYL--IDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGV-----IMREILVALISIHRDN- 132
+ +T L+++MEYC GG L +++ G E +Y+ +M ++ +AL HR +
Sbjct: 73 RIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSD 132
Query: 133 ----VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGV 188
V+HRD+K AN+ + +VKL DFG+A L+ +T GTPY+M+PE M +
Sbjct: 133 GGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQ-MNRM 191
Query: 189 YYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL 248
Y+ K DIWSLG YE+ PP+ I + K R+ R YS L E I
Sbjct: 192 SYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYR-YSDELNEIITR 250
Query: 249 CLDEDPKERPYAEELFKSKLI---------------------KQEKGTSTVILKELITRY 287
L+ RP EE+ ++ LI ++ S+ +L EL +
Sbjct: 251 MLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKE 310
Query: 288 LLFREKNEQYKHEEESHTSSKQ 309
+ +E+ K EE +Q
Sbjct: 311 IQLQERERALKAREERLEQKEQ 332
>7300559 [T] KOG4279 Serine/threonine protein kinase
Length = 1310
Score = 129 bits (325), Expect = 2e-29
Identities = 90/263 (34%), Positives = 136/263 (51%), Gaps = 11/263 (4%)
Query: 18 RKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITH 77
RK ++G+G +G VY A +TQ AIK + N++D V+ + +EI+ S L+ NI
Sbjct: 581 RKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQD-VQPLHEEIKLHSQLRHR-NIVR 638
Query: 78 YYGSYLIDTKLWVIMEYCAGGSLRTLLR----PGIIEEKYIGVIMREILVALISIHRDNV 133
Y GS + + ME GGSL LL P E + ++IL L +H ++
Sbjct: 639 YLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDI 698
Query: 134 IHRDIKAANILIAN-NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY-YD 191
+HRDIK N+L+ +G VK+ DFG + +L++ +T GT +MAPEVI +GV Y
Sbjct: 699 VHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYG 758
Query: 192 TKVDIWSLGITAYEIATGNPPYCHMEAIRA--MQMITKSKPPRLEGREYSQPLKEFIALC 249
DIWS G T E+ATG PP+ + + A ++ K P + E S K FI C
Sbjct: 759 PAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIP-EELSANAKNFILRC 817
Query: 250 LDEDPKERPYAEELFKSKLIKQE 272
+RP A +L + ++ +
Sbjct: 818 FAISVMDRPSASQLLEDPFLQDK 840
>Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 302
Score = 129 bits (323), Expect = 3e-29
Identities = 82/252 (32%), Positives = 129/252 (50%), Gaps = 11/252 (4%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVE--DIRKEIQFLSSLKQTP 73
F+ ++ IGRG+F VY+A + A+K + + + D D KEI L L P
Sbjct: 34 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNH-P 92
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTLLR-----PGIIEEKYIGVIMREILVALISI 128
N+ YY S++ D +L +++E G L +++ +I E+ + ++ AL +
Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152
Query: 129 HRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGV 188
H V+HRDIK AN+ I G VKL D G+ S ++ GTPY+M+PE I E
Sbjct: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHEN- 211
Query: 189 YYDTKVDIWSLGITAYEIATGNPPYC--HMEAIRAMQMITKSKPPRLEGREYSQPLKEFI 246
Y+ K DIWSLG YE+A P+ M + I + P L YS+ L++ +
Sbjct: 212 GYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLV 271
Query: 247 ALCLDEDPKERP 258
+C++ DP++RP
Sbjct: 272 NMCINPDPEKRP 283
>Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 620
Score = 128 bits (322), Expect = 4e-29
Identities = 91/261 (34%), Positives = 136/261 (51%), Gaps = 15/261 (5%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLD----NTEDEVEDIRKEIQFLSSLKQTPNI 75
+++G+G FG VY + V T + A+K + D T EV + EIQ L +L I
Sbjct: 361 KLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHE-RI 419
Query: 76 THYYGSYLI--DTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDN 132
YYG + L + MEY GGS++ L+ G + E R+IL + +H +
Sbjct: 420 VQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNM 479
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLK---RQTMAGTPYWMAPEVIMEGVY 189
++ RDIK ANIL + G+VKL DFG + +L L +++ GTPYWM+PEVI G
Sbjct: 480 IVLRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI-SGEG 538
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAM-QMITKSKPPRLEGREYSQPLKEFIAL 248
Y K DIWS+ T E+ T PP+ EA+ A+ ++ T+ P+L S ++F+
Sbjct: 539 YGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLP-PHVSDYTRDFLKR 597
Query: 249 CLDEDPKERPYAEELFKSKLI 269
E K RP A+EL + +
Sbjct: 598 IFVE-AKLRPSADELLRHMFV 617
>SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 127 bits (320), Expect = 7e-29
Identities = 92/265 (34%), Positives = 138/265 (51%), Gaps = 21/265 (7%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIK-VLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
+G G G V K TQ ++A+K VL NT + + +R E++ S +P I YYG
Sbjct: 85 LGEGVSGSVRKCRIRGTQMIFAMKTVLAAPNTALQKQLLR-ELKINRSCT-SPYIVKYYG 142
Query: 81 SYL--IDTKLWVIMEYCAGGSL-----RTLLRPGIIEEKYIGVIMREILVALISIHRDNV 133
+ + +L + MEYC GSL R + G E+ +G I +L L +H +
Sbjct: 143 ACYNNAECQLNIAMEYCGAGSLDAIYKRVRSQGGRTGERPLGKIAFGVLSGLSYLHDRKI 202
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
IHRDIK +NIL+ + G VKLCDFGV+ +L S+ T GT Y+MAPE I G Y
Sbjct: 203 IHRDIKPSNILLTSKGQVKLCDFGVSGELVNSL--AGTFTGTSYYMAPERI-SGGSYTIS 259
Query: 194 VDIWSLGITAYEIA--------TGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEF 245
DIWSLG+T E+A G+PP +E + + + P+ G ++S+ + F
Sbjct: 260 SDIWSLGLTLMEVALNRFPFPPEGSPPPMPIELLSYIINMPPPLLPQEPGIKWSKSFQHF 319
Query: 246 IALCLDEDPKERPYAEELFKSKLIK 270
+ +CLD+D RP +++ +K
Sbjct: 320 LCVCLDKDKTRRPGPQKMLTHPWVK 344
>Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1036
Score = 127 bits (319), Expect = 9e-29
Identities = 86/269 (31%), Positives = 134/269 (48%), Gaps = 17/269 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFH-VKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPN 74
+ +++++G G F VV++ H KT AIK +N N + KEI+ L L Q N
Sbjct: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKEL-QHEN 67
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNV 133
I Y + ++++MEYC GG L L+ G + E I V + +I A+ +H +
Sbjct: 68 IVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGI 127
Query: 134 IHRDIKAANILIA---------NNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI 184
IHRD+K NIL++ + +K+ DFG A L +M+ T+ G+P +MAPEVI
Sbjct: 128 IHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMM-AATLCGSPMYMAPEVI 186
Query: 185 MEGVYYDTKVDIWSLGITAYEIATGNPPY--CHMEAIRAMQMITKSKPPRLEGREYSQPL 242
M +YD K D+WS+G Y+ G PP+ + +R +S P + RE S L
Sbjct: 187 M-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIP-RETSPYL 244
Query: 243 KEFIALCLDEDPKERPYAEELFKSKLIKQ 271
+ L + K+R E F ++Q
Sbjct: 245 ANLLLGLLQRNQKDRMDFEAFFSHPFLEQ 273
>At5g19450 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 533
Score = 126 bits (317), Expect = 2e-28
Identities = 81/271 (29%), Positives = 135/271 (48%), Gaps = 11/271 (4%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTPNITHYY 79
+GRG+FG+ Y +KT + YA K ++ T ++ED+R+E++ + + + PNI
Sbjct: 63 VGRGEFGITYLCTDIKTGEKYACKSISKKKLRTAVDIEDVRREVEIMKHMPRHPNIVSLK 122
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
++ D + ++ME C GG L ++ G E+ +M+ IL + H+ V+HRD+
Sbjct: 123 DAFEDDDAVHIVMELCEGGELFDRIVARGHYTERAAAAVMKTILEVVQICHKHGVMHRDL 182
Query: 139 KAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L AN ++K DFG++ + + G+PY+MAPEV+ Y +VD
Sbjct: 183 KPENFLFANKKETSALKAIDFGLSVFFKPGEGFNE-IVGSPYYMAPEVLRRN--YGPEVD 239
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGREYSQPLKEFIALCLDED 253
IWS G+ Y + G PP+ Q I +S R S+ K+ + L+ D
Sbjct: 240 IWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSETAKDLVRKMLEPD 299
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVILKELI 284
PK+R A ++ + I+ K V L E +
Sbjct: 300 PKKRLSAAQVLEHSWIQNAKKAPNVSLGETV 330
>Hs21729899 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 258
Score = 126 bits (316), Expect = 2e-28
Identities = 82/258 (31%), Positives = 130/258 (49%), Gaps = 14/258 (5%)
Query: 45 KVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLL 104
+V+ LD T + + I E++ L + I +YG++ ++ ++ + E+ GGSL
Sbjct: 5 EVILLDITLELQKQIMSELEILYKCDSS-YIIGFYGAFFVENRISICTEFMDGGSLDVYR 63
Query: 105 RPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQ 164
+ + E +G I ++ L + ++HRD+K +N+L+ G VKLCDFGV+ QL
Sbjct: 64 K---MPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVN 120
Query: 165 SMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHME------- 217
S+ K T GT +MAPE I G Y D+WSLGI+ E+A G PY ++
Sbjct: 121 SIAK--TYVGTNAYMAPERI-SGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLM 177
Query: 218 AIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTST 277
++ +Q I P L E+S+P FI C+ + PKERP EEL I Q +
Sbjct: 178 PLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNA 237
Query: 278 VILKELITRYLLFREKNE 295
++ + R L R +
Sbjct: 238 AVVSMWVCRALEERRSQQ 255
>Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase
Length = 292
Score = 126 bits (316), Expect = 2e-28
Identities = 81/257 (31%), Positives = 129/257 (49%), Gaps = 8/257 (3%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTED-EVEDIRKEIQFLSSLKQTPNITHYY 79
++G+G +G V H + + Y IK LNL N E +E Q LS LK PNI Y
Sbjct: 11 VVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKH-PNIVTYK 69
Query: 80 GSYLI-DTKLWVIMEYCAGGSLRTLLRPG---IIEEKYIGVIMREILVALISIHRDNVIH 135
S+ D L+++M +C GG L L+ ++ E + +I +AL +H +++H
Sbjct: 70 ESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILH 129
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
RD+K N+ + +K+ D G+A L T+ GTPY+M+PE + Y+ K D
Sbjct: 130 RDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPE-LFSNKPYNYKSD 188
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPK 255
+W+LG YE+AT + + + I + K P + R+YS L E I L + P+
Sbjct: 189 VWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPAMP-RDYSPELAELIRTMLSKRPE 247
Query: 256 ERPYAEELFKSKLIKQE 272
ERP + + IK++
Sbjct: 248 ERPSVRSILRQPYIKRQ 264
>At4g08470 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 560
Score = 125 bits (315), Expect = 3e-28
Identities = 84/250 (33%), Positives = 131/250 (51%), Gaps = 11/250 (4%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDN----TEDEVEDIRKEIQFLSSLKQTPNI 75
+++GRG + VY+A + +A+K ++L + ++ ++ + EI LS L Q NI
Sbjct: 307 QLLGRGSYASVYEAIS-EDGDFFAVKEVSLLDKGIQAQECIQQLEGEIALLSQL-QHQNI 364
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIH 135
Y G+ +KL++ +E GS++ L + + + R+IL L +H +H
Sbjct: 365 VRYRGTAKDVSKLYIFLELVTQGSVQKLYERYQLSYTVVSLYTRQILAGLNYLHDKGFVH 424
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVYYDTK 193
RDIK AN+L+ NG+VKL DFG+A + + GT +WMAPEVI + +
Sbjct: 425 RDIKCANMLVDANGTVKLADFGLAE--ASKFNDIMSCKGTLFWMAPEVINRKDSDGNGSP 482
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDED 253
DIWSLG T E+ TG PY ++ I+A I + P + S + FI CL +
Sbjct: 483 ADIWSLGCTVLEMCTGQIPYSDLKPIQAAFKIGRGTLPDVPD-TLSLDARHFILTCLKVN 541
Query: 254 PKERPYAEEL 263
P+ERP A EL
Sbjct: 542 PEERPTAAEL 551
>At1g76040 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 534
Score = 125 bits (315), Expect = 3e-28
Identities = 86/297 (28%), Positives = 146/297 (48%), Gaps = 21/297 (7%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQT 72
L+ + +GRG+FG+ YK + YA K ++ ++ED+R+E+ L L
Sbjct: 84 LYDLHKELGRGQFGITYKCTDKSNGREYACKSISKRKLIRRKDIEDVRREVMILQHLTGQ 143
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRD 131
PNI + G+Y L ++ME C+GG L +++ G EK I R+I+ + H
Sbjct: 144 PNIVEFRGAYEDKDNLHLVMELCSGGELFDRIIKKGSYSEKEAANIFRQIVNVVHVCHFM 203
Query: 132 NVIHRDIKAANILIANN---GSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGV 188
V+HRD+K N L+ +N +K DFG++ + + + R + G+ Y++APEV+
Sbjct: 204 GVVHRDLKPENFLLVSNEEDSPIKATDFGLSVFIEEGKVYRD-IVGSAYYVAPEVLHRN- 261
Query: 189 YYDTKVDIWSLGITAYEIATGNPPY------CHMEAIRAMQMITKSKP-PRLEGREYSQP 241
Y ++D+WS G+ Y + +G PP+ EAI ++ ++ P P + S+
Sbjct: 262 -YGKEIDVWSAGVMLYILLSGVPPFWGETEKTIFEAILEGKLDLETSPWPTI-----SES 315
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYK 298
K+ I L DPK+R A E + + K + I ++ R FR N+ K
Sbjct: 316 AKDLIRKMLIRDPKKRITAAEALEHPWMTDTKISDKPINSAVLVRMKQFRAMNKLKK 372
>7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 735
Score = 125 bits (315), Expect = 3e-28
Identities = 83/262 (31%), Positives = 138/262 (51%), Gaps = 17/262 (6%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTED-EVEDIRKEIQFLSSLKQTPNITHYY 79
++G G FG YK T +++A K +N D ++ + + + EI L L Q PNI YY
Sbjct: 24 VMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQL-QHPNIVQYY 82
Query: 80 GSYLIDTK---LWVIMEYCAGGSLRTLLRPGI-----IEEKYIGVIMREILVALISIHRD 131
+L++ + ++++ME CAGG L +++ EE YI ++ ++ AL H
Sbjct: 83 -HHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNK 141
Query: 132 ----NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEG 187
++HRDIK ANI + G+ KL DFG+A L + + GTP++M+PE++ +G
Sbjct: 142 IPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELV-KG 200
Query: 188 VYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIA 247
YD K D+W++G YE+ PP+ + + I + + R+ YS L+E IA
Sbjct: 201 RKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPA-IYSTDLQEIIA 259
Query: 248 LCLDEDPKERPYAEELFKSKLI 269
L D ++RP E + + L+
Sbjct: 260 FMLAVDHEQRPGIEVIIRHPLV 281
>At4g32830 [D] KOG0580 Serine/threonine protein kinase
Length = 294
Score = 125 bits (314), Expect = 3e-28
Identities = 88/263 (33%), Positives = 136/263 (51%), Gaps = 14/263 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTED-EVE-DIRKEIQFLSSLKQTPNITHYY 79
+GRGKFG VY A ++ V A+KVL + +VE +R+E++ S L+ PNI Y
Sbjct: 37 LGRGKFGHVYLAREKRSNHVVALKVLFKSQLQQSQVEHQLRREVEIQSHLRH-PNILRLY 95
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G + ++++I+EY A G L + L + E+ + + ALI H +VIHRDI
Sbjct: 96 GYFYDQKRVYLILEYAARGELYKDLQKCKYFSERRAATYVASLARALIYCHGKHVIHRDI 155
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K N+LI G +K+ DFG + + +R+TM GT ++ PE++ E V +D VDIWS
Sbjct: 156 KPENLLIGAQGELKIADFGWSV---HTFNRRRTMCGTLDYLPPEMV-ESVEHDASVDIWS 211
Query: 199 LGITAYEIATGNPPY---CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPK 255
LGI YE G PP+ H + R + + PP+ S K+ I+ L ++
Sbjct: 212 LGILCYEFLYGVPPFEAMEHSDTYRRIVQVDLKFPPK---PIISASAKDLISQMLVKESS 268
Query: 256 ERPYAEELFKSKLIKQEKGTSTV 278
+R +L + I Q S +
Sbjct: 269 QRLPLHKLLEHPWIVQNADPSGI 291
>At2g25880 [D] KOG0580 Serine/threonine protein kinase
Length = 282
Score = 125 bits (313), Expect = 4e-28
Identities = 88/268 (32%), Positives = 136/268 (49%), Gaps = 32/268 (11%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVL-NLDNTEDEVE-DIRKEIQFLSSLKQTPNITHYY 79
+GRGKFG VY A ++ + A+KVL + +VE +R+E++ S L+ PNI Y
Sbjct: 25 LGRGKFGHVYLAREKRSDHIVALKVLFKAQLQQSQVEHQLRREVEIQSHLRH-PNILRLY 83
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G + ++++I+EY G L + L + E+ + + ALI H +VIHRDI
Sbjct: 84 GYFYDQKRVYLILEYAVRGELYKELQKCKYFSERRAATYVASLARALIYCHGKHVIHRDI 143
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K N+LI G +K+ DFG + + +R+TM GT ++ PE++ E V +D VDIWS
Sbjct: 144 KPENLLIGAQGELKIADFGWSV---HTFNRRRTMCGTLDYLPPEMV-ESVEHDASVDIWS 199
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKE-- 256
LGI YE G PP+ E RE+S+ K + + L PK
Sbjct: 200 LGILCYEFLYGVPPF--------------------EAREHSETYKRIVQVDLKFPPKPIV 239
Query: 257 RPYAEELFKSKLIKQEKGTSTVILKELI 284
A++L L+K+ T + L +L+
Sbjct: 240 SSSAKDLISQMLVKE--STQRLALHKLL 265
>7299057 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 424
Score = 125 bits (313), Expect = 4e-28
Identities = 82/269 (30%), Positives = 135/269 (49%), Gaps = 14/269 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IGRG FG V K K +V A+K + E E + + +++ + + I +YG+
Sbjct: 128 IGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGA 187
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGV-IMREILVALISI-----HRDNVIH 135
+ W+ ME + ++++I I+ +I VA ++ +IH
Sbjct: 188 LFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIH 247
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVYYDTK 193
RD+K +NIL+ G +KLCDFG++ QL S+ K + PY MAPE I YD +
Sbjct: 248 RDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPY-MAPERIDPERAKGYDVR 306
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAI-RAMQMITKSKPPRL----EGREYSQPLKEFIAL 248
D+WSLGIT E+ATGN PY +++ + + + +PPRL G E+S+ +F+
Sbjct: 307 SDVWSLGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNT 366
Query: 249 CLDEDPKERPYAEELFKSKLIKQEKGTST 277
CL + +RP L + I++ + + T
Sbjct: 367 CLIKKESDRPKYSRLLEMPFIRRGETSHT 395
>CE27177 [T] KOG4279 Serine/threonine protein kinase
Length = 1378
Score = 124 bits (312), Expect = 6e-28
Identities = 95/301 (31%), Positives = 151/301 (49%), Gaps = 23/301 (7%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
++G+G +G VY A + TQ+ +K + + ++EV+ + +EI S+L NI Y G
Sbjct: 669 VLGKGTYGTVYAARDMDTQRQIVVKEIEV-KYDEEVQPLMEEISLHSTLCHA-NIVQYLG 726
Query: 81 SYLI-----DTKLWVIMEYCAGGSLRTLLRP--GIIEEKYIGVIMREILVALISIHRDNV 133
L+ + + ME+ GGSL +LLR G + E + ++IL L +H +
Sbjct: 727 CDLVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKI 786
Query: 134 IHRDIKAANILIAN-NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY-YD 191
+HRDIK N+L+ +G K+ DFG +L+ +T GT +MAPEVI G Y
Sbjct: 787 VHRDIKGDNVLVNTYSGVCKISDFGTCKRLAGLNPVTETFTGTLQYMAPEVIDHGQRGYG 846
Query: 192 TKVDIWSLGITAYEIATGNPPYCHMEAIRAMQM---ITKSKPPRLEGREYSQPLKEFIAL 248
DIWS G T E+ATG PP+ M+ +A + K+ PP E ++ + FI
Sbjct: 847 APADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPP--IPTEITEKCRNFIKS 904
Query: 249 CLDEDPKERPYAEELFKSKLIKQ-----EKGTSTVILKELITRYLL--FREKNEQYKHEE 301
C + +RP A++L + I + S I K+ T+ L +EK E+ K++
Sbjct: 905 CFLPEACDRPSAKDLLQDPFIYHNHHSISRTRSGSINKKPATKIELNHDKEKKEKSKNQR 964
Query: 302 E 302
E
Sbjct: 965 E 965
>YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 515
Score = 124 bits (310), Expect = 1e-27
Identities = 99/322 (30%), Positives = 155/322 (47%), Gaps = 42/322 (13%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLD-NTEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
IG G G V KA HV ++ A K + ++ N + + +E+ + ++K NI +YG
Sbjct: 197 IGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYG 256
Query: 81 SYL---IDTKLWVIMEYCAGGSLRTLL-------RPGIIEEKY-------IGVIMREILV 123
+Y I+ ++ ++MEY GSL +L + G + K I I +L
Sbjct: 257 AYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLN 316
Query: 124 ALISIHRD-NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPE 182
L ++R +IHRDIK +N+LI + G +KLCDFGV+ +L S+ T GT +M+PE
Sbjct: 317 GLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSI--ADTFVGTSTYMSPE 374
Query: 183 VIMEGVYYDTKVDIWSLGITAYEIATGNPPY-CHMEA----IRAMQMITKSKPPRL-EGR 236
I +G Y K D+WSLG+ E+ TG P H + + +Q I PRL + R
Sbjct: 375 RI-QGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDR 433
Query: 237 EYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQ--------------EKGTSTVILKE 282
YS+ + +F+ C ++ +ER EL LI + K S + +
Sbjct: 434 IYSKEMTDFVNRCCIKNERERSSIHELLHHDLIMKYVSPSKDDKFRHWCRKIKSKIKEDK 493
Query: 283 LITRYLLFREKNEQYKHEEESH 304
I R L R K E+ + E +H
Sbjct: 494 RIKREALDRAKLEKKQSERSTH 515
>Hs4759178 [D] KOG0580 Serine/threonine protein kinase
Length = 344
Score = 124 bits (310), Expect = 1e-27
Identities = 81/242 (33%), Positives = 126/242 (51%), Gaps = 15/242 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--VEDIRKEIQFLSSLKQTPNITHYY 79
+G+GKFG VY A K+ + A+KVL E E +R+EI+ + L PNI Y
Sbjct: 83 LGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH-PNILRLY 141
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
+ ++++I+EY G L + L + +E+ IM E+ AL+ H VIHRDI
Sbjct: 142 NYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDI 201
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K N+L+ G +K+ DFG + L+R+TM GT ++ PE+I EG ++ KVD+W
Sbjct: 202 KPENLLLGLKGELKIADFGWSVHAPS--LRRKTMCGTLDYLPPEMI-EGRMHNEKVDLWC 258
Query: 199 LGITAYEIATGNPPY---CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPK 255
+G+ YE+ GNPP+ H E R + + P + ++ I+ L +P
Sbjct: 259 IGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASV-----PTGAQDLISKLLRHNPS 313
Query: 256 ER 257
ER
Sbjct: 314 ER 315
>Hs5174547 [T] KOG4279 Serine/threonine protein kinase
Length = 1374
Score = 123 bits (309), Expect = 1e-27
Identities = 87/257 (33%), Positives = 129/257 (49%), Gaps = 9/257 (3%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
++G+G +G+VY + Q AIK + + + + +EI LK NI Y G
Sbjct: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHLKHK-NIVQYLG 742
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLLR----PGIIEEKYIGVIMREILVALISIHRDNVIHR 136
S+ + + + ME GGSL LLR P E+ IG ++IL L +H + ++HR
Sbjct: 743 SFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHR 802
Query: 137 DIKAANILI-ANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY-YDTKV 194
DIK N+LI +G +K+ DFG + +L+ +T GT +MAPE+I +G Y
Sbjct: 803 DIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAA 862
Query: 195 DIWSLGITAYEIATGNPPYCHM-EAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDED 253
DIWSLG T E+ATG PP+ + E AM + K S K FI C + D
Sbjct: 863 DIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPD 922
Query: 254 PKERPYAEELFKSKLIK 270
P +R A +L + +K
Sbjct: 923 PDKRACANDLLVDEFLK 939
>Hs4507275 [D] KOG0580 Serine/threonine protein kinase
Length = 403
Score = 123 bits (309), Expect = 1e-27
Identities = 79/250 (31%), Positives = 134/250 (53%), Gaps = 15/250 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--VEDIRKEIQFLSSLKQTPNITHYY 79
+G+GKFG VY A +++ + A+KVL E +R+E++ S L+ PNI Y
Sbjct: 139 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH-PNILRLY 197
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G + T++++I+EY G++ R L + +E+ + E+ AL H VIHRDI
Sbjct: 198 GYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDI 257
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K N+L+ + G +K+ DFG + S +R T+ GT ++ PE+I EG +D KVD+WS
Sbjct: 258 KPENLLLGSAGELKIADFGWSVHAPSS--RRTTLCGTLDYLPPEMI-EGRMHDEKVDLWS 314
Query: 199 LGITAYEIATGNPPY---CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPK 255
LG+ YE G PP+ + E + + + + P + ++ ++ I+ L +P
Sbjct: 315 LGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFV-----TEGARDLISRLLKHNPS 369
Query: 256 ERPYAEELFK 265
+RP E+ +
Sbjct: 370 QRPMLREVLE 379
>CE07399 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 343
Score = 123 bits (309), Expect = 1e-27
Identities = 80/264 (30%), Positives = 130/264 (48%), Gaps = 12/264 (4%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
E +G+G +G+V K H ++ + A+K + + + + E+ P + +Y
Sbjct: 54 EELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFY 113
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLRPGI-----IEEKYIGVIMREILVALISIHRD-NV 133
G+ + +W+ ME SL R I E +IG + ++ L + N+
Sbjct: 114 GAMFREGDVWICMEVM-DTSLDKFYRHAYKIGKHIPEPFIGKMALSVIEGLNFMKEQLNL 172
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI--MEGVYYD 191
IHRD+K +NIL+ +G VK+CDFG++ L+ SM K AG +M PE I YD
Sbjct: 173 IHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAK-TVQAGCKPYMPPERIDGETKSAYD 231
Query: 192 TKVDIWSLGITAYEIATGNPPYCHMEA-IRAMQMITKSKPPRLEGRE-YSQPLKEFIALC 249
+ D+WSLGIT EIA G PY + + ++ + K PP+L +S + F+ C
Sbjct: 232 VRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRC 291
Query: 250 LDEDPKERPYAEELFKSKLIKQEK 273
L++D ERP EL ++Q +
Sbjct: 292 LEKDYNERPKYPELLAMPFMEQAR 315
>Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 393
Score = 123 bits (308), Expect = 2e-27
Identities = 85/300 (28%), Positives = 144/300 (47%), Gaps = 48/300 (16%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
F++ +G G GVV+K H + V A K+++L+ I +E+Q L +P I
Sbjct: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYI 126
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIH-RDNV 133
+YG++ D ++ + ME+ GGSL + L + G I E+ +G + ++ L + + +
Sbjct: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
+HRD+K +NIL+ + G +KLCDFGV+ QL SM + GT +M+PE ++G +Y +
Sbjct: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPE-RLQGTHYSVQ 243
Query: 194 VDIWSLGITAYEIATGNPPY-------------CHMEAIRA------------------- 221
DIWS+G++ E+A G P C +E A
Sbjct: 244 SDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMD 303
Query: 222 ----------MQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQ 271
+ I PP+L +S ++F+ CL ++P ER ++L IK+
Sbjct: 304 SRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKR 363
>ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 488
Score = 123 bits (308), Expect = 2e-27
Identities = 79/272 (29%), Positives = 144/272 (52%), Gaps = 8/272 (2%)
Query: 19 KEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEV--EDIRKEIQFLSSLKQTPNIT 76
K+++GRG + Y A +++ + YA+KV+ L + + E + EI S L PN+
Sbjct: 43 KKLLGRGAYAQCYLA-EIESGEQYAMKVVRLKDIKSRKVHEKLESEIAIHSKL-DNPNVV 100
Query: 77 HYYGSYLIDTKLWVIMEYCAGGSLRTLL-RPGIIEEKYIGVIMREILVALISIHRD-NVI 134
Y S+ +++++E C G+L LL R G ++E+++ +++ + LI +H +V+
Sbjct: 101 KMYRSFRSSEYVFMVLELCERGALDALLKRNGKLKERHVARFVKQTVEGLIYLHNSVSVV 160
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM-EGVYYDTK 193
HRD+K N+ + + +VK+ DFG++A + K+ TM GTP ++APEV+ + + +
Sbjct: 161 HRDLKLGNLFLDSKFNVKIGDFGLSAVIKDGE-KKVTMCGTPNYIAPEVLFGKASGHSFE 219
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDED 253
DIWSLG+ Y + G PP+ +MI + E + S + I L+ +
Sbjct: 220 ADIWSLGVIIYTLLVGVPPFQKKNVEDIYKMIKLNNYIFPENCDLSSEAIDLITQILNTN 279
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVILKELIT 285
P ERP E + K + +++ I + L+T
Sbjct: 280 PLERPTLEHILSHKFLSKKEHFLMKIYRNLMT 311
>At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 520
Score = 123 bits (308), Expect = 2e-27
Identities = 84/258 (32%), Positives = 127/258 (48%), Gaps = 8/258 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IG G VV +A H+ ++ A+K +N+ E + + EI+ L + ++G+
Sbjct: 89 IGSGASSVVQRAIHIPNHRILALKKINIFEREKR-QQLLTEIRTLCEAPCHEGLVDFHGA 147
Query: 82 YLIDT--KLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIHR-DNVIHRD 137
+ ++ + +EY GGSL +L+ I E + + ++L L +H +++HRD
Sbjct: 148 FYSPDSGQISIALEYMNGGSLADILKVTKKIPEPVLSSLFHKLLQGLSYLHGVRHLVHRD 207
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIW 197
IK AN+LI G K+ DFG++A L SM T GT +M+PE I Y DIW
Sbjct: 208 IKPANLLINLKGEPKITDFGISAGLENSMAMCATFVGTVTYMSPERIRND-SYSYPADIW 266
Query: 198 SLGITAYEIATGNPPYCHMEA-IRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKE 256
SLG+ +E TG PY E + M I P +E+S FI CL +DP
Sbjct: 267 SLGLALFECGTGEFPYIANEGPVNLMLQILDDPSPTPPKQEFSPEFCSFIDACLQKDPDA 326
Query: 257 RPYAEELFKSKLI-KQEK 273
RP A++L I K EK
Sbjct: 327 RPTADQLLSHPFITKHEK 344
>At4g04740 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 520
Score = 123 bits (308), Expect = 2e-27
Identities = 83/285 (29%), Positives = 139/285 (48%), Gaps = 11/285 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEV--EDIRKEIQFLSSLKQTPNITHYY 79
+GRG G+ Y + T +YA K + E+ ED++ EIQ + L PN+
Sbjct: 75 LGRGGLGITYMCKEIGTGNIYACKSILKRKLISELGREDVKTEIQIMQHLSGQPNVVEIK 134
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
GSY + ++ME CAGG L ++ G E+ ++ I+ + H + VIHRD+
Sbjct: 135 GSYEDRHSVHLVMELCAGGELFDRIIAQGHYSERAAAGTIKSIVDVVQICHLNGVIHRDL 194
Query: 139 KAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L ++ N +K+ DFG++A + + + + + G+PY++APEV+ + Y ++D
Sbjct: 195 KPENFLFSSKEENAMLKVTDFGLSAFIEEGKIYKD-VVGSPYYVAPEVLRQS--YGKEID 251
Query: 196 IWSLGITAYEIATGNPPYC--HMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDED 253
IWS G+ Y + G PP+ + E + + K R S K+ + L ED
Sbjct: 252 IWSAGVILYILLCGVPPFWADNEEGVFVEILKCKIDFVREPWPSISDSAKDLVEKMLTED 311
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYK 298
PK R A ++ + IK + I +++R FR N+ K
Sbjct: 312 PKRRITAAQVLEHPWIKGGEAPEKPIDSTVLSRMKQFRAMNKLKK 356
>At2g45490 [D] KOG0580 Serine/threonine protein kinase
Length = 288
Score = 123 bits (308), Expect = 2e-27
Identities = 82/247 (33%), Positives = 132/247 (53%), Gaps = 8/247 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEV--EDIRKEIQFLSSLKQTPNITHYY 79
+G+GKFG VY A K++ + A+KV+ + E +R+E++ +SL+ PNI +
Sbjct: 28 LGKGKFGRVYLAREAKSKYIVALKVIFKEQIEKYKIHHQLRREMEIQTSLRH-PNILRLF 86
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G + + ++++I+EY GG L +L+ G + E+ + + AL H VIHRDI
Sbjct: 87 GWFHDNERIFLILEYAHGGELYGVLKQNGHLTEQQAATYIASLSQALAYCHGKCVIHRDI 146
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K N+L+ + G +K+ DFG + Q S KR+TM GT ++APE++ E +D VD W+
Sbjct: 147 KPENLLLDHEGRLKIADFGWSVQSSN---KRKTMCGTLDYLAPEMV-ENRDHDYAVDNWT 202
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERP 258
LGI YE GNPP+ + I K S+ K I+ L +DP +R
Sbjct: 203 LGILCYEFLYGNPPFEAESQKDTFKRILKIDLSFPLTPNVSEEAKNLISQLLVKDPSKRL 262
Query: 259 YAEELFK 265
E++ +
Sbjct: 263 SIEKIMQ 269
>SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 362
Score = 122 bits (307), Expect = 2e-27
Identities = 81/266 (30%), Positives = 131/266 (48%), Gaps = 17/266 (6%)
Query: 18 RKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE-------VEDIRKEIQFLSSLK 70
R +IG G FG VY + + ++ A+K + LD+ + ++ + EI L L
Sbjct: 99 RGALIGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELS 158
Query: 71 QTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIH 129
+I Y GS L L + +EY GGS+ LL G EE + +++ L L +H
Sbjct: 159 HE-HIVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLH 217
Query: 130 RDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLK------RQTMAGTPYWMAPEV 183
++HRDIK ANIL+ N G +K+ DFG++ +L + R + G+ +WMAPEV
Sbjct: 218 SRGIVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEV 277
Query: 184 IMEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLK 243
+ + ++ + K DIWSLG E+ T PY + + ++A+ I ++ P S +
Sbjct: 278 VKQTMHTE-KTDIWSLGCLVIEMLTSKHPYPNCDQMQAIFRIGENILPEFPSNISSSAI- 335
Query: 244 EFIALCLDEDPKERPYAEELFKSKLI 269
+F+ D RP A EL +
Sbjct: 336 DFLEKTFAIDCNLRPTASELLSHPFV 361
>Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 419
Score = 122 bits (307), Expect = 2e-27
Identities = 80/258 (31%), Positives = 135/258 (52%), Gaps = 9/258 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G G V+K KT V A+K + ++E + I ++ + P I +G+
Sbjct: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISI-HRDNVIHRDIK 139
++ +T +++ ME + + R G I E+ +G + I+ AL + + VIHRD+K
Sbjct: 186 FITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVK 245
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI----MEGVYYDTKVD 195
+NIL+ G +KLCDFG++ +L S K ++ AG +MAPE I YD + D
Sbjct: 246 PSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTKPDYDIRAD 304
Query: 196 IWSLGITAYEIATGNPPYCHMEA-IRAMQMITKSKPPRLEGR-EYSQPLKEFIALCLDED 253
+WSLGI+ E+ATG PY + + + + + +PP L G +S + F+ CL +D
Sbjct: 305 VWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKD 364
Query: 254 PKERPYAEELFKSKLIKQ 271
++RP +L + IK+
Sbjct: 365 HRKRPKYNKLLEHSFIKR 382
>At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 348
Score = 122 bits (307), Expect = 2e-27
Identities = 87/266 (32%), Positives = 138/266 (51%), Gaps = 14/266 (5%)
Query: 17 KRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVE-DIRKEIQFLSSLKQTPNI 75
+R IG G G VYK H T + +A+KV+ N ED V I +EI+ L S+ PN+
Sbjct: 71 ERVNRIGSGAGGTVYKVIHTPTSRPFALKVI-YGNHEDTVRRQICREIEILRSVDH-PNV 128
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIH 135
+ + + ++ V++E+ GSL I +E+ + + R+IL L +HR +++H
Sbjct: 129 VKCHDMFDHNGEIQVLLEFMDQGSLEGA---HIWQEQELADLSRQILSGLAYLHRRHIVH 185
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI----MEGVYYD 191
RDIK +N+LI + +VK+ DFGV+ L+Q+M + GT +M+PE I G Y
Sbjct: 186 RDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNHGRYDG 245
Query: 192 TKVDIWSLGITAYEIATGNPPYC---HMEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL 248
D+WSLG++ E G P+ + M I S+PP SQ + F++
Sbjct: 246 YAGDVWSLGVSILEFYLGRFPFAVSRQGDWASLMCAICMSQPPEAPATA-SQEFRHFVSC 304
Query: 249 CLDEDPKERPYAEELFKSKLIKQEKG 274
CL DP +R A++L + I + G
Sbjct: 305 CLQSDPPKRWSAQQLLQHPFILKATG 330
>7292829 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 492
Score = 122 bits (307), Expect = 2e-27
Identities = 80/259 (30%), Positives = 132/259 (50%), Gaps = 14/259 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G G V K H+ + + A+K + +E + I ++ + I G
Sbjct: 203 LGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGC 262
Query: 82 YLIDTKLWVIMEY---CAGGSLRTLLRPGIIEEKYIGVIMREILVALISIH-RDNVIHRD 137
++ D +W+ ME C L+ +P + E+ +G + + AL + + VIHRD
Sbjct: 263 FVRDPDVWICMELMSMCFDKLLKLSKKP--VPEQILGKVTVATVNALSYLKDKHGVIHRD 320
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI-MEGVYYDTKVDI 196
+K +NILI G++KLCDFG++ +L S ++ AG +MAPE I + YD + D+
Sbjct: 321 VKPSNILIDERGNIKLCDFGISGRLVDSKANTRS-AGCAAYMAPERIDPKKPKYDIRADV 379
Query: 197 WSLGITAYEIATGNPPY--CHMEAIRAMQMITKSKPPRL---EGREYSQPLKEFIALCLD 251
WSLGIT E+AT PY C+ + + + S+PP L EG +SQ ++F+ CL
Sbjct: 380 WSLGITLVELATARSPYEGCNTD-FEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLT 438
Query: 252 EDPKERPYAEELFKSKLIK 270
++ ++RP EL I+
Sbjct: 439 KNHQDRPKYPELLAQPFIR 457
>SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 460
Score = 122 bits (306), Expect = 3e-27
Identities = 82/251 (32%), Positives = 137/251 (53%), Gaps = 17/251 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLN-----LDNTEDEVEDI-RKEIQFLSSLKQTPNI 75
+G G F VV A V + + YAIK++N L ++E ++ ++EI L SL P +
Sbjct: 173 LGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSLHH-PGV 231
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+ + D +L+++MEY GG L L+ G I+E+ +++++L L+ +H+ V
Sbjct: 232 VQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLHKQGVT 291
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI------MEGV 188
HRDIK NILI N+ +K+ DFG+A + + +T GT ++APEV+ ++G
Sbjct: 292 HRDIKPENILITNDFHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNVNLDG- 350
Query: 189 YYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPP--RLEGREYSQPLKEFI 246
YD KVDIWSLG Y + T + P+ + +++I+K P L E S+ + I
Sbjct: 351 GYDDKVDIWSLGCVLYVMLTASIPFASSSQAKCIELISKGAYPIEPLLENEISEEGIDLI 410
Query: 247 ALCLDEDPKER 257
L+ +P++R
Sbjct: 411 NRMLEINPEKR 421
>At2g41860 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 530
Score = 122 bits (306), Expect = 3e-27
Identities = 80/277 (28%), Positives = 136/277 (48%), Gaps = 11/277 (3%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTP 73
+K +GRG+FGV Y ++T +++A K + T ++ED+++E++ + + + P
Sbjct: 54 YKLGRELGRGEFGVTYLCTEIETGEIFACKSILKKKLKTSIDIEDVKREVEIMRQMPEHP 113
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDN 132
NI +Y D + ++ME C GG L ++ G E+ +++ I+ + H+
Sbjct: 114 NIVTLKETYEDDKAVHLVMELCEGGELFDRIVARGHYTERAAASVIKTIIEVVQMCHKHG 173
Query: 133 VIHRDIKAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY 189
V+HRD+K N L AN S+K DFG++ + + G+PY+MAPEV+
Sbjct: 174 VMHRDLKPENFLFANKKETASLKAIDFGLSVFFKPGE-RFNEIVGSPYYMAPEVLRRS-- 230
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGREYSQPLKEFIA 247
Y ++DIWS G+ Y + G PP+ + I KS R + S K+ I
Sbjct: 231 YGQEIDIWSAGVILYILLCGVPPFWAETEHGVAKAILKSVIDFKRDPWPKVSDNAKDLIK 290
Query: 248 LCLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELI 284
L DP+ R A+++ I+ K S V L E +
Sbjct: 291 KMLHPDPRRRLTAQQVLDHPWIQNGKNASNVSLGETV 327
>HsM4507279 [D] KOG0580 Serine/threonine protein kinase
Length = 402
Score = 122 bits (305), Expect = 4e-27
Identities = 79/250 (31%), Positives = 133/250 (52%), Gaps = 15/250 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--VEDIRKEIQFLSSLKQTPNITHYY 79
+G+GKFG VY A +++ + A+KVL E +R+E++ S L+ PNI Y
Sbjct: 138 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH-PNILRLY 196
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G + T++++I+EY G++ R L + +E+ + I AL H VIHRDI
Sbjct: 197 GYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTANLYNRIANALSYCHSKRVIHRDI 256
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K N+L+ + G +K+ DFG + S +R T+ GT ++ PE+I EG +D KVD+WS
Sbjct: 257 KPENLLLGSAGELKIADFGWSVHAPSS--RRTTLCGTLDYLPPEMI-EGRMHDEKVDLWS 313
Query: 199 LGITAYEIATGNPPY---CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPK 255
LG+ YE G PP+ + E + + + + P + ++ ++ I+ L +P
Sbjct: 314 LGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFV-----TEGARDLISRLLKHNPS 368
Query: 256 ERPYAEELFK 265
+RP E+ +
Sbjct: 369 QRPMLREVLE 378
>7293496 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 805
Score = 121 bits (304), Expect = 5e-27
Identities = 69/206 (33%), Positives = 112/206 (53%), Gaps = 3/206 (1%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNL-DNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
++G+G FG VYKA +V AIKV++ E++++R+E + LK P++
Sbjct: 9 MVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKH-PHVIEMI 67
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIK 139
S+ T L+V+ E+ R L G + E+ + ++ AL +H + ++HRD+K
Sbjct: 68 ESFESKTDLFVVTEFALMDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNRILHRDLK 127
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSL 199
N+L+ N KLCDFG+A ++ ++ GTP +MAPE++ E YD D+WSL
Sbjct: 128 PQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQP-YDHHADMWSL 186
Query: 200 GITAYEIATGNPPYCHMEAIRAMQMI 225
G AYE G PP+C + ++MI
Sbjct: 187 GCIAYESMAGQPPFCASSILHLVKMI 212
>7292679 [G] KOG0599 Phosphorylase kinase gamma subunit
Length = 560
Score = 121 bits (304), Expect = 5e-27
Identities = 79/272 (29%), Positives = 134/272 (49%), Gaps = 17/272 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--------VEDIRKEIQFLS 67
++ KEI+GRG V + +T + +A K+++L T + +E R+EI L
Sbjct: 23 YEPKEILGRGISSTVRRCIEKETGKEFAAKIIDLGATTESGETNPYHMLEATRQEISILR 82
Query: 68 SLKQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALI 126
+ P I + D ++++ E C G L L + + EK IMR+I +
Sbjct: 83 QVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVE 142
Query: 127 SIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIME 186
IH +++HRD+K NIL+ N +VK+ DFG A QL + K + GTP ++APE +
Sbjct: 143 YIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQEGE-KLTNLCGTPGYLAPETLKC 201
Query: 187 GVY-----YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKP--PRLEGREYS 239
++ Y +VDIW+ G+ + + G PP+ H + + ++ I + K E + S
Sbjct: 202 NMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADIS 261
Query: 240 QPLKEFIALCLDEDPKERPYAEELFKSKLIKQ 271
+ K+ I CL DP +R +E+ + Q
Sbjct: 262 EDPKDLIRKCLVVDPSQRITVKEVLRHPFFNQ 293
>YPL209c [D] KOG0580 Serine/threonine protein kinase
Length = 367
Score = 121 bits (303), Expect = 6e-27
Identities = 81/248 (32%), Positives = 135/248 (53%), Gaps = 14/248 (5%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTP 73
F+ + +G+GKFG VY H T + A+KV+ + + + R+E++ +SL P
Sbjct: 104 FELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNH-P 162
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIHRDN 132
N+T YG + + +++++MEY G + LLR G + + +I AL +H+ N
Sbjct: 163 NLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMHKKN 222
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
+IHRDIK NILI N +KL DFG + ++ +R+T+ GT +++PE++ E YD
Sbjct: 223 IIHRDIKPENILIGFNNVIKLTDFGWSI-INPPENRRKTVCGTIDYLSPEMV-ESREYDH 280
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGR---EYSQPLKEFIALC 249
+D W+LG+ A+E+ TG PP+ M+ T + L+ + SQ ++ I
Sbjct: 281 TIDAWALGVLAFELLTGAPPF-----EEEMKDTTYKRIAALDIKMPSNISQDAQDLILKL 335
Query: 250 LDEDPKER 257
L DPK+R
Sbjct: 336 LKYDPKDR 343
>YNR031c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1579
Score = 121 bits (303), Expect = 6e-27
Identities = 89/296 (30%), Positives = 141/296 (47%), Gaps = 41/296 (13%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTED--EVEDIRKEIQFLSSLKQTP 73
++++ IG G FG VY A + ++ A+K +N+ +++ ++ + KE + + P
Sbjct: 1266 WQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHP 1325
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIG-VIMREILVALISIHRDN 132
NI YYG + K+ + MEYC GGSL LL G IE++ + V ++L L +H
Sbjct: 1326 NIVSYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIEDEMVTQVYTLQLLEGLAYLHESG 1385
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQ------SMLKRQT--------------- 171
++HRD+K NIL+ NG +K DFG A +++ SM K +
Sbjct: 1386 IVHRDVKPENILLDFNGVIKYVDFGAAKKIANNGTRLASMNKIENADGEHEDVTHVSDSK 1445
Query: 172 -----------MAGTPYWMAPEVIMEGVYYDTKV---DIWSLGITAYEIATGNPPYCHME 217
M GTP +MAPE I G K+ D+WSLG E+ TG P+ +++
Sbjct: 1446 AVKNNENALLDMMGTPMYMAPESI-TGSTTKGKLGADDVWSLGCVVLEMITGRRPWANLD 1504
Query: 218 AIRA-MQMITKSKPPRLEGR-EYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQ 271
A M + P+ + E S +F+ CL ++P +R A EL I Q
Sbjct: 1505 NEWAIMYHVAAGHTPQFPTKDEVSSAGMKFLERCLIQNPSKRASAVELLMDPWIVQ 1560
>SPCC162.10 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 338
Score = 121 bits (303), Expect = 6e-27
Identities = 84/271 (30%), Positives = 133/271 (48%), Gaps = 11/271 (4%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLD-NTEDEVEDIRKEIQFLSSLKQTPN 74
FK + +IG+G + V+ H +T+Q +A+K +N + E +++ +R E+ L SL P
Sbjct: 30 FKIRNVIGKGSWSTVFVVKHRQTKQRFALKCINKKKHDEHKIKKLRNEVLLLQSLNH-PL 88
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+ +Y + +TK++++ + GG LR + E I + M E++ ALI IH V+
Sbjct: 89 LCKFYSEFEDETKIYLVTDLMLGGDLRYHISQRKFNESVIRIWMVELVSALIYIHSKGVL 148
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQT-----MAGTPYWMAPEVIMEGVY 189
HRD+K NIL+ G KL DF VAA++ S ++ GTP +MAPE ++ V
Sbjct: 149 HRDVKPDNILLDEKGHCKLADFNVAAKVHTSSSPSKSNMTVGRVGTPVYMAPETLIHAVS 208
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCH---MEAIRAMQMITKSKPPRLEGREYSQPLKEFI 246
Y + D WSLGIT YE P+ + + IRA + S RL + K+
Sbjct: 209 Y-KESDWWSLGITFYECLFQVRPFPNHLLINWIRASEEEKASSADRLSSALHISRDKKLT 267
Query: 247 ALCLDEDPKERPYAEELFKSKLIKQEKGTST 277
+ D + E K +L K T
Sbjct: 268 TISKDARSAVMAFLEMDIKKRLGHSSKKLQT 298
>Hs21735542 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 462
Score = 121 bits (303), Expect = 6e-27
Identities = 79/258 (30%), Positives = 134/258 (51%), Gaps = 9/258 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G G V+K KT V A+K + ++E + I ++ + P I +G+
Sbjct: 169 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 228
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISI-HRDNVIHRDIK 139
++ +T +++ ME + + R G I E+ +G + I+ AL + + VIHRD+K
Sbjct: 229 FITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVK 288
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI----MEGVYYDTKVD 195
+NIL+ G +K CDFG++ +L S K ++ AG +MAPE I YD + D
Sbjct: 289 PSNILLDERGQIKFCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTKPDYDIRAD 347
Query: 196 IWSLGITAYEIATGNPPYCHMEA-IRAMQMITKSKPPRLEGR-EYSQPLKEFIALCLDED 253
+WSLGI+ E+ATG PY + + + + + +PP L G +S + F+ CL +D
Sbjct: 348 VWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKD 407
Query: 254 PKERPYAEELFKSKLIKQ 271
++RP +L + IK+
Sbjct: 408 HRKRPKYNKLLEHSFIKR 425
>At4g04720 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 531
Score = 121 bits (303), Expect = 6e-27
Identities = 82/286 (28%), Positives = 141/286 (48%), Gaps = 13/286 (4%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVL---NLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
+GRG+FG+ Y + T YA K + L + +D+ ED+++EIQ + L PNI
Sbjct: 86 LGRGQFGITYMCKEIGTGNTYACKSILKRKLISKQDK-EDVKREIQIMQYLSGQPNIVEI 144
Query: 79 YGSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
G+Y + ++ME CAGG L ++ G E+ I+R I+ + H V+HRD
Sbjct: 145 KGAYEDRQSIHLVMELCAGGELFDRIIAQGHYSERAAAGIIRSIVNVVQICHFMGVVHRD 204
Query: 138 IKAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
+K N L+++ N +K DFG++ + + + R + G+ Y++APEV+ Y ++
Sbjct: 205 LKPENFLLSSKEENAMLKATDFGLSVFIEEGKVYRD-IVGSAYYVAPEVLRRS--YGKEI 261
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE--GREYSQPLKEFIALCLDE 252
DIWS G+ Y + +G PP+ + K + + S+ K+ + L +
Sbjct: 262 DIWSAGVILYILLSGVPPFWAENEKGIFDEVIKGEIDFVSEPWPSISESAKDLVRKMLTK 321
Query: 253 DPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYK 298
DPK R A ++ + IK + I +++R FR N+ K
Sbjct: 322 DPKRRITAAQVLEHPWIKGGEAPDKPIDSAVLSRMKQFRAMNKLKK 367
>Hs4505785 [G] KOG0599 Phosphorylase kinase gamma subunit
Length = 406
Score = 120 bits (301), Expect = 1e-26
Identities = 77/274 (28%), Positives = 141/274 (51%), Gaps = 20/274 (7%)
Query: 19 KEIIGRGKFGVVYKAFHVKTQQVYAIKVLNL-------DNTEDEVEDIRKEIQFLSSLKQ 71
K++IGRG VV + H T +A+K++ + + E+ E R+E L +
Sbjct: 27 KDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAG 86
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALISIHR 130
P+I SY + ++++ + G L L + + EK IMR +L A+ +H
Sbjct: 87 HPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHA 146
Query: 131 DNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI---MEG 187
+N++HRD+K NIL+ +N ++L DFG + L K + + GTP ++APE++ M+
Sbjct: 147 NNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGE-KLRELCGTPGYLAPEILKCSMDE 205
Query: 188 VY--YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSK----PPRLEGREYSQP 241
+ Y +VD+W+ G+ + + G+PP+ H I ++MI + + P + R S
Sbjct: 206 THPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDR--SST 263
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIKQEKGT 275
+K+ I+ L DP+ R AE+ + ++ +G+
Sbjct: 264 VKDLISRLLQVDPEARLTAEQALQHPFFERCEGS 297
>Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 514
Score = 120 bits (301), Expect = 1e-26
Identities = 89/328 (27%), Positives = 160/328 (48%), Gaps = 18/328 (5%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT-EDEVEDIRKEIQFLSSLKQTPNITHYY 79
I+G+G FG+V +A +T+ +AIK +N + V+ + +E+ L S+K +I H
Sbjct: 121 ILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHE-HIIHLE 179
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLL-RPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
+ K++++ME C G L+ +L R G E I++ + A+ +H ++++HRD+
Sbjct: 180 QVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDL 239
Query: 139 KAANILIAN---------NGSVKLCDFGVAAQL-SQSMLKRQTMAGTPYWMAPEVIMEGV 188
K NI++ + N ++K+ DFG+A + S+S Q GTP +MAPEVI
Sbjct: 240 KLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVI-SAH 298
Query: 189 YYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKP--PRLEGREYSQPLKEFI 246
Y + DIWS+G+ Y + G PP+ + ++I K + S K +
Sbjct: 299 DYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVL 358
Query: 247 ALCLDEDPKERPYAEELFKSKLIKQEKGTST--VILKELITRYLLFREKNEQYKHEEESH 304
+ DP R A+EL ++ + K +S + E++ + E E+ EE++
Sbjct: 359 KQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNK 418
Query: 305 TSSKQNPNSSIEGNASQDAGSFTEKEPE 332
S+++ S DA +++E E
Sbjct: 419 PSTEEKLKSYQPWGNVPDANYTSDEEEE 446
>Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 278
Score = 120 bits (301), Expect = 1e-26
Identities = 87/275 (31%), Positives = 132/275 (47%), Gaps = 14/275 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+GRG +GVV K HV + Q+ A+K + E + + ++ P +YG+
Sbjct: 3 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 62
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGI-----IEEKYIGVIMREILVALISIHRD-NVIH 135
+ +W+ ME SL + I I E +G I I+ AL +H +VIH
Sbjct: 63 LFREGDMWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 121
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI---MEGVYYDT 192
RD+K +N+LI G VK+CDFG++ L S+ K PY MAPE I + Y
Sbjct: 122 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGYSV 180
Query: 193 KVDIWSLGITAYEIATGNPPYCHM-EAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLD 251
K DIWSLGIT E+A PY + ++ + + P+L ++S +F + CL
Sbjct: 181 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 240
Query: 252 EDPKERPYAEELFKSKL--IKQEKGTSTVILKELI 284
++ KERP EL + + + KGT +LI
Sbjct: 241 KNSKERPTYPELMQHPFFTLHESKGTDVASFVKLI 275
>At5g25110 [T] KOG0583 Serine/threonine protein kinase
Length = 460
Score = 120 bits (301), Expect = 1e-26
Identities = 81/250 (32%), Positives = 129/250 (51%), Gaps = 15/250 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--VEDIRKEIQFLSSLKQTP 73
++ ++G+G FG VY + T + AIK++N D + E +E I++EI + ++ P
Sbjct: 15 YEMGRLLGKGTFGKVYYGKEITTGESVAIKIINKDQVKREGMMEQIKREISIMRLVRH-P 73
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNV 133
NI TK++ IMEY GG L + + G ++E ++++ A+ H V
Sbjct: 74 NIVELKEVMATKTKIFFIMEYVKGGELFSKIVKGKLKEDSARKYFQQLISAVDFCHSRGV 133
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAA---QLSQSMLKRQTMAGTPYWMAPEVIMEGVYY 190
HRD+K N+L+ NG +K+ DFG++A Q+ Q L T GTP ++APEV+ + Y
Sbjct: 134 SHRDLKPENLLVDENGDLKVSDFGLSALPEQILQDGL-LHTQCGTPAYVAPEVLRKKGYD 192
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSK---PPRLEGREYSQPLKEFIA 247
K DIWS GI Y + G P+ ++ + I KS+ PP +S K I+
Sbjct: 193 GAKGDIWSCGIILYVLLAGFLPFQDENLMKMYRKIFKSEFEYPP-----WFSPESKRLIS 247
Query: 248 LCLDEDPKER 257
L DP +R
Sbjct: 248 KLLVVDPNKR 257
>YLR362w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 717
Score = 120 bits (300), Expect = 1e-26
Identities = 86/291 (29%), Positives = 135/291 (45%), Gaps = 50/291 (17%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT-----------------------EDEVED 58
IG G FG VY + T ++ A+K + + N ++++ED
Sbjct: 421 IGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIED 480
Query: 59 I--------------------RKEIQFLSSLKQTPNITHYYGSYLIDTKLWVIMEYCAGG 98
+ + E+ L L NI YYG+ L + +EY GG
Sbjct: 481 VGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHE-NIVTYYGASQEGGNLNIFLEYVPGG 539
Query: 99 SLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNVIHRDIKAANILIANNGSVKLCDFG 157
S+ ++L G EE I R+IL+ + +H+ N+IHRDIK ANILI G VK+ DFG
Sbjct: 540 SVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFG 599
Query: 158 VAAQLS---QSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITAYEIATGNPPYC 214
++ +LS + KR ++ G+ +WM+PEV+ + K DIWS G E+ TG P+
Sbjct: 600 ISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQ-TATTAKADIWSTGCVVIEMFTGKHPFP 658
Query: 215 HMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERPYAEELFK 265
++A+ I + P + S+ K F+ + D + RP A EL +
Sbjct: 659 DFSQMQAIFKIGTNTTPEIPSWATSEG-KNFLRKAFELDYQYRPSALELLQ 708
>Hs4507273 [D] KOG0580 Serine/threonine protein kinase
Length = 275
Score = 120 bits (300), Expect = 1e-26
Identities = 87/251 (34%), Positives = 132/251 (51%), Gaps = 20/251 (7%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--VEDIRKEIQFLSSLKQTPNITHYY 79
+G+GKFG VY A ++ + A+KVL E E +R+EI+ + L Q PNI Y
Sbjct: 15 LGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHL-QHPNILRLY 73
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
+ ++++I+EY G L + L + ++E+ I+ E+ AL H VIHRDI
Sbjct: 74 NYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEEVADALTYCHDKKVIHRDI 133
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K N+L+ G VK+ DFG + + + +R+TM GT ++ PE+I EG YD KVD+W
Sbjct: 134 KPENLLLGFRGEVKIADFGWS--VHTPLPERKTMCGTLDYLPPEMI-EGRTYDEKVDLWC 190
Query: 199 LGITAYEIATGNPPY---CHMEAIRAMQMITKSKPPRLEGREYSQPL--KEFIALCLDED 253
+G+ YE+ G PP+ H E R + + P S PL ++ I+ L
Sbjct: 191 IGVLCYELLVGYPPFESASHSETYRRILKVDVRFP-------LSMPLGARDLISRLLRYQ 243
Query: 254 PKER-PYAEEL 263
P ER P A+ L
Sbjct: 244 PLERLPLAQIL 254
>Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 334
Score = 120 bits (300), Expect = 1e-26
Identities = 87/275 (31%), Positives = 132/275 (47%), Gaps = 14/275 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+GRG +GVV K HV + Q+ A+K + E + + ++ P +YG+
Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGI-----IEEKYIGVIMREILVALISIHRD-NVIH 135
+ +W+ ME SL + I I E +G I I+ AL +H +VIH
Sbjct: 119 LFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI---MEGVYYDT 192
RD+K +N+LI G VK+CDFG++ L S+ K PY MAPE I + Y
Sbjct: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGYSV 236
Query: 193 KVDIWSLGITAYEIATGNPPYCHM-EAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLD 251
K DIWSLGIT E+A PY + ++ + + P+L ++S +F + CL
Sbjct: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 296
Query: 252 EDPKERPYAEELFKSKL--IKQEKGTSTVILKELI 284
++ KERP EL + + + KGT +LI
Sbjct: 297 KNSKERPTYPELMQHPFFTLHESKGTDVASFVKLI 331
>At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 465
Score = 120 bits (300), Expect = 1e-26
Identities = 85/279 (30%), Positives = 144/279 (51%), Gaps = 14/279 (5%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTP 73
F+ +++G+G FG VY+ +T ++YA+KV+ D+ ++ E ++ E L+ + P
Sbjct: 134 FEVMKVVGKGAFGKVYQVRKKETSEIYAMKVMRKDHIMEKNHAEYMKAERDILTKIDH-P 192
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLR-TLLRPGIIEEKYIGVIMREILVALISIHRDN 132
I S+ +L++++++ GG L L G+ E V EI+ A+ +H
Sbjct: 193 FIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKG 252
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
++HRD+K NIL+ +G V L DFG+A + ++ + +M GT +MAPE++ G +D
Sbjct: 253 IMHRDLKPENILMDTDGHVMLTDFGLAKEFEEN-TRSNSMCGTTEYMAPEIV-RGKGHDK 310
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGREYSQPLKEFIALCL 250
D WS+GI YE+ TG PP+ + + Q I K K P+ E LK L
Sbjct: 311 AADWWSVGILLYEMLTGKPPFLGSKG-KIQQKIVKDKIKLPQFLSNEAHAILKGL----L 365
Query: 251 DEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLL 289
++P ER L ++ IKQ K + K+L R ++
Sbjct: 366 QKEP-ERRLGSGLSGAEEIKQHKWFKGINWKKLEAREVM 403
>At3g20860 [R] KOG0589 Serine/threonine protein kinase
Length = 427
Score = 119 bits (299), Expect = 2e-26
Identities = 85/314 (27%), Positives = 151/314 (48%), Gaps = 23/314 (7%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIR-KEIQFLSSLKQTPNITHY 78
E IGRG FG + H ++ Y +K + L + + +E+ +S LK +P I Y
Sbjct: 19 EQIGRGAFGSAFLVIHKSERRKYVVKKIRLAKQTERCKLAAIQEMSLISKLK-SPYIVEY 77
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRPG---IIEEKYIGVIMREILVALISIHRDNVIH 135
S++ + ++ YC GG + +++ E+ + M ++L+A+ +H + V+H
Sbjct: 78 KDSWVEKDCVCIVTSYCEGGDMTQMIKKSRGVFASEEKLCRWMVQLLLAIDYLHNNRVLH 137
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
RD+K +NI + V+L DFG+A L + L +M GTP +M PE++ + + Y K D
Sbjct: 138 RDLKCSNIFLTKENEVRLGDFGLAKLLGKDDL-ASSMVGTPNYMCPELLAD-IPYGYKSD 195
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPK 255
IWSLG +E+A P + + + I +S L YS LK I L ++P+
Sbjct: 196 IWSLGCCMFEVAAHQPAFKAPDMAALINKINRSSLSPLPVM-YSSSLKRLIKSMLRKNPE 254
Query: 256 ERPYAEELFKSKLIK---QEKGTSTVILKELITRYLLFREKNE------------QYKHE 300
RP A EL + ++ + + + K ++++ +N KH
Sbjct: 255 HRPTAAELLRHPHLQPYLAQCQNLSPVFKPVVSKSEHNTNENRTGLPPKTKSAKTPIKHN 314
Query: 301 EESHTSSKQNPNSS 314
+ES + K+N ++S
Sbjct: 315 QESEETEKKNKDTS 328
>At1g50700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 521
Score = 119 bits (299), Expect = 2e-26
Identities = 84/290 (28%), Positives = 147/290 (49%), Gaps = 20/290 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTPNITHYY 79
+GRG+FGV Y T + +A K ++ T+ + ED+R+EIQ + L PNI +
Sbjct: 79 LGRGQFGVTYLCTEKSTGKRFACKSISKKKLVTKGDKEDMRREIQIMQHLSGQPNIVEFK 138
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G+Y + + ++ME CAGG L +L G E+ + R+I+ + H V+HRD+
Sbjct: 139 GAYEDEKAVNLVMELCAGGELFDRILAKGHYSERAAASVCRQIVNVVNICHFMGVMHRDL 198
Query: 139 KAANILIANNGS---VKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L+++ +K DFG++ + + + + + G+ Y++APEV+ Y ++D
Sbjct: 199 KPENFLLSSKDEKALIKATDFGLSVFIEEGRVYKD-IVGSAYYVAPEVLKR--RYGKEID 255
Query: 196 IWSLGITAYEIATGNPPYCH------MEAIRAMQMITKSKPPRLEGREYSQPLKEFIALC 249
IWS GI Y + +G PP+ +AI ++ +S+P S K+ +
Sbjct: 256 IWSAGIILYILLSGVPPFWAETEKGIFDAILEGEIDFESQP----WPSISNSAKDLVRRM 311
Query: 250 LDEDPKERPYAEELFKSKLIKQ-EKGTSTVILKELITRYLLFREKNEQYK 298
L +DPK R A E+ K +++ + + I +++R FR N+ K
Sbjct: 312 LTQDPKRRISAAEVLKHPWLREGGEASDKPIDSAVLSRMKQFRAMNKLKK 361
>At1g18890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 545
Score = 119 bits (299), Expect = 2e-26
Identities = 78/276 (28%), Positives = 134/276 (48%), Gaps = 21/276 (7%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTPNITHYY 79
+GRG+FG+ Y +T + A K ++ T ++ED+R+E+ +S+L + PN+
Sbjct: 69 LGRGEFGITYLCTDRETHEALACKSISKRKLRTAVDIEDVRREVAIMSTLPEHPNVVKLK 128
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
SY + + ++ME C GG L ++ G E+ + R I ++ H + V+HRD+
Sbjct: 129 ASYEDNENVHLVMELCEGGELFDRIVARGHYTERAAAAVARTIAEVVMMCHSNGVMHRDL 188
Query: 139 KAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L AN N +K DFG++ K + G+PY+MAPEV+ Y VD
Sbjct: 189 KPENFLFANKKENSPLKAIDFGLSVFFKPGD-KFTEIVGSPYYMAPEVLKRD--YGPGVD 245
Query: 196 IWSLGITAYEIATGNPPY-------CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL 248
+WS G+ Y + G PP+ + +R + + P++ S+ K +
Sbjct: 246 VWSAGVIIYILLCGVPPFWAETEQGVALAILRGVLDFKRDPWPQI-----SESAKSLVKQ 300
Query: 249 CLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELI 284
LD DP +R A+++ I+ K V L +++
Sbjct: 301 MLDPDPTKRLTAQQVLAHPWIQNAKKAPNVPLGDIV 336
>CE29622 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 371
Score = 119 bits (298), Expect = 2e-26
Identities = 92/280 (32%), Positives = 140/280 (49%), Gaps = 23/280 (8%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE------VEDIRKEIQFLSSLKQTP 73
E++G G FGVV K H + A+K ++L N + ++ R E++ +
Sbjct: 75 ELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCD 134
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTL------LRPGIIEEKYIGVIMREILVALIS 127
I YYG + W+ ME SL L ++ I E+ +G + + AL
Sbjct: 135 EIVRYYGITFNEGVAWMCMELM-DLSLDKLYMIAHDIQKVEIPEQILGAVAVATIRALEH 193
Query: 128 IHRDN-VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPE-VIM 185
+ + +IHRDIK +NIL+ +G VKLCDFG+ L S+ + + PY MAPE +
Sbjct: 194 LKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPY-MAPERLAP 252
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPY-CHMEA--IRAMQMITKSKPPRLEG-REYSQP 241
G YD K ++WSLGIT E+A G PY M+A + ++M+ PP L+ E S
Sbjct: 253 NGDGYDIKSEVWSLGITMVEVANGKYPYDGFMDAPILDQVRMVVYGDPPILDSDHEVSMS 312
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLIK---QEKGTSTV 278
+K FIALC +D R ++L K+ + + QE+ TV
Sbjct: 313 MKRFIALCTIKDRNLRASFDDLKKTNIYRDYIQEEHRVTV 352
>At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 277
Score = 119 bits (298), Expect = 2e-26
Identities = 83/253 (32%), Positives = 124/253 (48%), Gaps = 13/253 (5%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEV--EDIRKEIQFLSSLKQTPNITHYY 79
IGRG+FG + + F T++ YA K ++ D + E I E + ++ L PNI +
Sbjct: 17 IGRGRFGTITRCFSPATKEFYACKTIDKRVLIDALDRECIETEPRIMAMLPPHPNIIRIF 76
Query: 80 GSYLIDTKLWVIMEYCAGGSL---RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHR 136
Y + L ++ME R + G + E ++IL AL HR +V+HR
Sbjct: 77 DLYETEDSLAIVMELVDPPMTIYDRLISAGGRLSESESASYAKQILSALAHCHRCDVVHR 136
Query: 137 DIKAANILI-ANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
D+K N+L+ +G VKLCDFG A L + + GTPY++APEV+M G YD KVD
Sbjct: 137 DVKPDNVLVDLVSGGVKLCDFGSAVWLGGETA--EGVVGTPYYVAPEVVM-GRKYDEKVD 193
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSK---PPRLEGREYSQPLKEFIALCLDE 252
IWS G+ Y + G PP+ A + I + PP+ G S K+ + +
Sbjct: 194 IWSAGVVIYTMLAGEPPFNGETAEDIFESILRGNLRFPPKKFG-SVSSEAKDLLRKMICR 252
Query: 253 DPKERPYAEELFK 265
D R AE+ +
Sbjct: 253 DVSRRFSAEDALR 265
>SPCC320.12c [D] KOG0580 Serine/threonine protein kinase
Length = 384
Score = 118 bits (295), Expect = 5e-26
Identities = 84/268 (31%), Positives = 145/268 (53%), Gaps = 12/268 (4%)
Query: 15 LFKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDN-TEDEVE-DIRKEIQFLSSLKQT 72
+F+ + +G+GKFG VY A KT + A+K L+ + ++E +R+EI+ S+L+
Sbjct: 117 MFEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHK 176
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRD 131
NI YG + + ++++I+E+ G L + L R E+ + ++ AL +H+
Sbjct: 177 -NILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLHKK 235
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYD 191
+VIHRDIK NIL+ +G +KL DFG + + +R T+ GT ++ PE++ EG +
Sbjct: 236 HVIHRDIKPENILLGIDGEIKLSDFGWSVHAPSN--RRTTLCGTLDYLPPEMV-EGKEHT 292
Query: 192 TKVDIWSLGITAYEIATGNPPYCHMEAIRA-MQMITKSKPPRLEGREYSQP-LKEFIALC 249
KVD+WSLG+ YE G PP+ M A + I K L+ + P ++ I+
Sbjct: 293 EKVDLWSLGVLTYEFLVGAPPFEDMSGHSATYKRIAKVD---LKIPSFVPPDARDLISRL 349
Query: 250 LDEDPKERPYAEELFKSKLIKQEKGTST 277
L +P++R E++ + I + K + T
Sbjct: 350 LQHNPEKRMSLEQVMRHPWIVKYKDSWT 377
>ECU07g0360 [D] KOG0580 Serine/threonine protein kinase
Length = 272
Score = 118 bits (295), Expect = 5e-26
Identities = 81/271 (29%), Positives = 135/271 (48%), Gaps = 18/271 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTP 73
F+ ++GRGKFG V+ A + + A+K++ + T + IR+EI+ S+LK P
Sbjct: 10 FEIGRLLGRGKFGQVWLAREREKGFIVALKIIPIKEIQTVETARQIRREIEIHSNLKH-P 68
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTLL--RPGIIEEKYIGVIMREILVALISIHRD 131
NI YG + +++I+EY G L R G EK + +R++++AL +
Sbjct: 69 NILRMYGHFHDKDNIYLILEYAGKGEFFKFLSDRGGKFGEKETSLYIRQVMLALTYMKEC 128
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYD 191
NVIHRDIK N+L+ ++ +K+ DFG A + +R T GT ++APE++ + +D
Sbjct: 129 NVIHRDIKPENLLLGSDNQLKIADFGWAVYNADK--RRMTFCGTMEYLAPEMVNNDI-HD 185
Query: 192 TKVDIWSLGITAYEIATGNPPY-----CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFI 246
+ +D+W LGI YE G P+ EA + + + + P + S +FI
Sbjct: 186 SGIDLWCLGILTYEFLMGKTPFESKNRNMREAYKKINSLKYTIPETI-----SSNASDFI 240
Query: 247 ALCLDEDPKERPYAEELFKSKLIKQEKGTST 277
+ L P +R E I + G S+
Sbjct: 241 SRLLVLSPGDRMELTEALNHPFIVKHHGRSS 271
>Hs20550407 [T] KOG0201 Serine/threonine protein kinase
Length = 112
Score = 117 bits (294), Expect = 7e-26
Identities = 59/111 (53%), Positives = 76/111 (68%), Gaps = 1/111 (0%)
Query: 92 MEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAANILIANNGSV 151
MEY GGS LL PG ++E I I+REIL L +H + IHR +KAAN+L++ + V
Sbjct: 1 MEYPDGGSTLDLLEPGPLDETQIITILREILKGLDYLHSEKKIHRGVKAANVLLSEHCEV 60
Query: 152 KLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGIT 202
KL DFG+A QL+ + KR T GTP+W+APEVI + YD+K DIWSLGIT
Sbjct: 61 KLVDFGMAGQLADTQTKRNTFVGTPFWIAPEVIKQSA-YDSKADIWSLGIT 110
>At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 648
Score = 117 bits (293), Expect = 9e-26
Identities = 93/334 (27%), Positives = 154/334 (45%), Gaps = 28/334 (8%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVED-IRKEIQFLSSLKQTPNITHYYG 80
IG G F VV+ A H + A+K ++ +V D + KEI LS++ PNI +Y
Sbjct: 16 IGSGSFAVVWLAKHRSSGLEVAVKEIDKKLLSPKVRDNLLKEISILSTIDH-PNIIRFYE 74
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLL-RPGIIEEKYIGVIMREILVALISIHRDNVIHRDIK 139
+ ++++++EYC+GG L + R G + E MR++ + L + + IHRD+K
Sbjct: 75 AIETGDRIFLVLEYCSGGDLAGYINRHGKVPEAVAKHFMRQLALGLQVLQEKHFIHRDLK 134
Query: 140 AANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDI 196
N+L+++ +K+ DFG A L+ + +T G+P +MAPE+I YD K D+
Sbjct: 135 PQNLLLSSKEVTPLLKIGDFGFARSLTPESM-AETFCGSPLYMAPEII-RNQKYDAKADL 192
Query: 197 WSLGITAYEIATGNPPY---CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDED 253
WS G +++ TG PP+ H++ + T+ K P E + L +
Sbjct: 193 WSAGAILFQLVTGKPPFDGNNHIQLFHNIVRDTELKFPEDTRNEIHPDCVDLCRSLLRRN 252
Query: 254 PKERPYAEELFKSKLIKQEK--------GTSTVILKELI------TRYLLFREKNEQ-YK 298
P ER E F +++ + G ST K L+ T F+ E +K
Sbjct: 253 PIERLTFREFFNHMFLREPRQIPDVEHSGFSTCTGKSLLPSAQPSTSTNRFKSSAENVHK 312
Query: 299 HEEESHTSSKQ--NPNSSIEGNASQDAGSFTEKE 330
H S S+ Q P++S E G + +
Sbjct: 313 HGSSSSASNSQISMPHTSFEKTRKDTEGQCSSNQ 346
>YPL150w [T] KOG0583 Serine/threonine protein kinase
Length = 901
Score = 117 bits (292), Expect = 1e-25
Identities = 84/293 (28%), Positives = 146/293 (49%), Gaps = 22/293 (7%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+K + IG G FG VY A H T + +K + N + V ++ QF P I
Sbjct: 41 YKILKQIGEGSFGKVYLALHRPTHRKVCLKTSD-KNDPNIVREVFYHRQF-----DFPYI 94
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLR----TLLRPGIIEEKYIGVIMREILVALISIHRD 131
T Y + ++K+W+ +EYC G L +L R ++E G + +I A+ H
Sbjct: 95 TKLYEVIVTESKVWMALEYCPGKELYDHLLSLRRISLLE---CGELFAQISGAVYYAHSM 151
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYD 191
+ +HRD+K NIL+ NG+ KL DFG + + +T+ GT +MAPE+I Y
Sbjct: 152 HCVHRDLKLENILLDKNGNAKLTDFGFTREC-MTKTTLETVCGTTVYMAPELIERRTYDG 210
Query: 192 TKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLD 251
K+DIWSLG+ Y + TG P+ + + I ++ P+ + + ++ I+ L
Sbjct: 211 FKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIV-NEEPKYDAKVIPDDARDLISRLLA 269
Query: 252 EDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKN--EQYKHEEE 302
++P ERP ++ + ++ +V+L + T+ +L R+++ Q+K + E
Sbjct: 270 KNPGERPSLSQVLRHPFLQP---YGSVVLDQ--TQKILCRQRSGGTQFKSKLE 317
>Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 400
Score = 117 bits (292), Expect = 1e-25
Identities = 86/306 (28%), Positives = 142/306 (46%), Gaps = 52/306 (16%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
F+R +G G GVV K H + + A K+++L+ I +E+Q L +P I
Sbjct: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECN-SPYI 130
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALISIH-RDNV 133
+YG++ D ++ + ME+ GGSL +L+ I E+ +G + +L L + + +
Sbjct: 131 VGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQI 190
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
+HRD+K +NIL+ + G +KLCDFGV+ QL SM + GT +MAPE ++G +Y +
Sbjct: 191 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMAPE-RLQGTHYSVQ 247
Query: 194 VDIWSLGITAYEIATGN-----PPYCHMEAI----------------------------- 219
DIWS+G++ E+A G P +EAI
Sbjct: 248 SDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSG 307
Query: 220 ------------RAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKERPYAEELFKSK 267
+ I PP+L ++ +EF+ CL ++P ER + L
Sbjct: 308 HGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHT 367
Query: 268 LIKQEK 273
IK+ +
Sbjct: 368 FIKRSE 373
>CE04724 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 505
Score = 117 bits (292), Expect = 1e-25
Identities = 80/262 (30%), Positives = 127/262 (47%), Gaps = 8/262 (3%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYY 79
E IG G G V K + + A+K + + E+ I ++ + P I +
Sbjct: 76 EDIGHGSCGTVTKCRYKSV--IMAVKTMPRTSNSYEMSRILMDLDVICLSFDCPYIVRCF 133
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIH-RDNVIHRD 137
G ++ + + V ME A R L+R I E+ IG + I+ AL + + ++HRD
Sbjct: 134 GYFITNFDVRVCMECMATCLDRLLIRIKQPIPERIIGKLSVSIIKALHYLKTKHQIMHRD 193
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY--YDTKVD 195
+K +NIL+ +G +KLCDFG+A +L +S AG P +M PE + + YD + D
Sbjct: 194 VKPSNILLDWSGVIKLCDFGIAGRLIESR-AHSKQAGCPLYMGPERLDPNNFDSYDIRSD 252
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPK 255
+WS G+T E+ATG PY E M I +PPRL+ ++S + + CL DP
Sbjct: 253 VWSFGVTLVELATGQYPYAGTE-FDMMSKILNDEPPRLDPAKFSPDFCQLVESCLQRDPT 311
Query: 256 ERPYAEELFKSKLIKQEKGTST 277
RP + L + + + T
Sbjct: 312 MRPNYDMLLQHPFVVHHEKIET 333
>At5g45820 [T] KOG0583 Serine/threonine protein kinase
Length = 439
Score = 117 bits (292), Expect = 1e-25
Identities = 91/353 (25%), Positives = 169/353 (47%), Gaps = 21/353 (5%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--VEDIRKEIQFLSSLKQTPNITHY 78
++G+G F VY A ++KT + AIKV++ ++ I++EI + ++ P++
Sbjct: 17 LLGQGTFAKVYHARNIKTGESVAIKVIDKQKVAKVGLIDQIKREISVMRLVRH-PHVVFL 75
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
+ TK++ MEY GG L + G ++E ++++ A+ H V HRD+
Sbjct: 76 HEVMASKTKIYFAMEYVKGGELFDKVSKGKLKENIARKYFQQLIGAIDYCHSRGVYHRDL 135
Query: 139 KAANILIANNGSVKLCDFGVAA--QLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDI 196
K N+L+ NG +K+ DFG++A + Q T GTP ++APEVI + Y K D+
Sbjct: 136 KPENLLLDENGDLKISDFGLSALRESKQQDGLLHTTCGTPAYVAPEVIGKKGYDGAKADV 195
Query: 197 WSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGREYSQPLKEFIALCLDEDP 254
WS G+ Y + G P+ + + ITK K P + +K+ ++ LD +P
Sbjct: 196 WSCGVVLYVLLAGFLPFHEQNLVEMYRKITKGEFKCPNW----FPPEVKKLLSRILDPNP 251
Query: 255 KERPYAEELFKS-------KLIKQEKGTSTVILKELITR-YLLFREKNEQYKHEEESHTS 306
R E++ ++ K I+ K + + LI+ + F K Y + +
Sbjct: 252 NSRIKIEKIMENSWFQKGFKKIETPKSPESHQIDSLISDVHAAFSVKPMSYNAFDLISSL 311
Query: 307 SKQNPNSSIEGNASQDAGSF-TEKEPEDIDIKWDFDSLSSREY-ILENDINVE 357
S+ S + + F T+K+ ++I K++ + SS + + ++D+ V+
Sbjct: 312 SQGFDLSGLFEKEERSESKFTTKKDAKEIVSKFEEIATSSERFNLTKSDVGVK 364
>At4g23650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 529
Score = 117 bits (292), Expect = 1e-25
Identities = 87/291 (29%), Positives = 143/291 (48%), Gaps = 22/291 (7%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTPNITHYY 79
+GRG+FGV Y H +T+Q A K + +D++ED+R+E+Q + L NI
Sbjct: 84 LGRGQFGVTYLVTHKETKQQVACKSIPTRRLVHKDDIEDVRREVQIMHHLSGHRNIVDLK 143
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G+Y + +IME C GG L ++ G+ E+ + R++++ + S H V+HRD+
Sbjct: 144 GAYEDRHSVNLIMELCEGGELFDRIISKGLYSERAAADLCRQMVMVVHSCHSMGVMHRDL 203
Query: 139 KAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L + N +K DFG++ K + + G+ Y++APEV+ Y + D
Sbjct: 204 KPENFLFLSKDENSPLKATDFGLSVFFKPGD-KFKDLVGSAYYVAPEVLKRN--YGPEAD 260
Query: 196 IWSLGITAYEIATGNPPYCH------MEAIRAMQMITKSKP-PRLEGREYSQPLKEFIAL 248
IWS G+ Y + +G PP+ +AI Q+ + P P L S K+ +
Sbjct: 261 IWSAGVILYILLSGVPPFWGENETGIFDAILQGQLDFSADPWPAL-----SDGAKDLVRK 315
Query: 249 CLDEDPKERPYAEELFKSKLIKQEKGTSTVIL-KELITRYLLFREKNEQYK 298
L DPK+R A E+ I+++ S L +++R FR N+ K
Sbjct: 316 MLKYDPKDRLTAAEVLNHPWIREDGEASDKPLDNAVLSRMKQFRAMNKLKK 366
>At1g29230 [T] KOG0583 Serine/threonine protein kinase
Length = 520
Score = 117 bits (292), Expect = 1e-25
Identities = 88/310 (28%), Positives = 148/310 (47%), Gaps = 22/310 (7%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--VEDIRKEIQFLSSLKQTPNITH 77
+++G G F VY A ++K+ AIKV++ + V I++EI L ++ P I H
Sbjct: 78 KLLGHGTFAKVYLAQNIKSGDKVAIKVIDKEKIMKSGLVAHIKREISILRRVRH-PYIVH 136
Query: 78 YYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
+ +K++ +MEY GG L + G + E+ ++++ ++ H V HRD
Sbjct: 137 LFEVMATKSKIYFVMEYVGGGELFNTVAKGRLPEETARRYFQQLISSVSFCHGRGVYHRD 196
Query: 138 IKAANILIANNGSVKLCDFG---VAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
+K N+L+ N G++K+ DFG VA QL Q L T GTP ++APEV+ Y K
Sbjct: 197 LKPENLLLDNKGNLKVSDFGLSAVAEQLRQDGL-CHTFCGTPAYIAPEVLTRKGYDAAKA 255
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGREYSQPLKEFIALCLDE 252
D+WS G+ + + G+ P+ + + I K + PR +S L + LD
Sbjct: 256 DVWSCGVILFVLMAGHIPFYDKNIMVMYKKIYKGEFRCPRW----FSSDLVRLLTRLLDT 311
Query: 253 DPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPN 312
+P R E+ K++ K KG V ++ + +K + +EE SS +
Sbjct: 312 NPDTRITIPEIMKNRWFK--KGFKHV-------KFYIEDDKLCREDEDEEEEASSSGRSS 362
Query: 313 SSIEGNASQD 322
+ E +A D
Sbjct: 363 TVSESDAEFD 372
>CE29092 [T] KOG0694 Serine/threonine protein kinase
Length = 707
Score = 116 bits (291), Expect = 2e-25
Identities = 70/201 (34%), Positives = 107/201 (52%), Gaps = 4/201 (1%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTP 73
F +++G+G FG V A T +VYAIK+L D +D+VE E + LS + P
Sbjct: 378 FTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHP 437
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLR-TLLRPGIIEEKYIGVIMREILVALISIHRDN 132
+T + S+ +L+ +MEY GG L + R +E E+ AL +HR++
Sbjct: 438 FLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRND 497
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
VI+RD+K NIL+ G +L DFG+ + T GTP ++APE++ E + Y
Sbjct: 498 VIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQE-MEYGV 556
Query: 193 KVDIWSLGITAYEIATGNPPY 213
VD W+LG+ YE+ G PP+
Sbjct: 557 SVDWWALGVLMYEMMAGQPPF 577
>At4g18700 [T] KOG0583 Serine/threonine protein kinase
Length = 489
Score = 116 bits (291), Expect = 2e-25
Identities = 78/261 (29%), Positives = 134/261 (50%), Gaps = 9/261 (3%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--VEDIRKEIQFLSSLKQTP 73
++ +++G G F VY A +VKT + AIKV++ + + I++EI L ++ P
Sbjct: 26 YEMGKLLGHGTFAKVYLARNVKTNESVAIKVIDKEKVLKGGLIAHIKREISILRRVRH-P 84
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNV 133
NI + K++ +MEY GG L + G ++E+ ++++ A+ H V
Sbjct: 85 NIVQLFEVMATKAKIYFVMEYVRGGELFNKVAKGRLKEEVARKYFQQLISAVTFCHARGV 144
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAA---QLSQSMLKRQTMAGTPYWMAPEVIMEGVYY 190
HRD+K N+L+ NG++K+ DFG++A Q+ Q L T GTP ++APEV+ Y
Sbjct: 145 YHRDLKPENLLLDENGNLKVSDFGLSAVSDQIRQDGL-FHTFCGTPAYVAPEVLARKGYD 203
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
KVDIWS G+ + + G P+ H + AM R R +S L ++ L
Sbjct: 204 AAKVDIWSCGVILFVLMAGYLPF-HDRNVMAMYKKIYRGEFRCP-RWFSTELTRLLSKLL 261
Query: 251 DEDPKERPYAEELFKSKLIKQ 271
+ +P++R E+ ++ K+
Sbjct: 262 ETNPEKRFTFPEIMENSWFKK 282
>7301213 [R] KOG0589 Serine/threonine protein kinase
Length = 841
Score = 116 bits (291), Expect = 2e-25
Identities = 77/257 (29%), Positives = 129/257 (49%), Gaps = 17/257 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIR-KEIQFLSSLKQTPN 74
+++ ++G+G FG+ K +NL D+ E+ S L PN
Sbjct: 105 YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHH-PN 163
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLL--RPGIIE--EKYIGVIMREILVALISIHR 130
I Y GS++ D L + MEY GG+L ++ R G + E+YI + +I A+ +H
Sbjct: 164 IVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHS 223
Query: 131 DNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYY 190
+N++HRD+K AN+ + G VK+ DFG+ +++ + + QT+ GTPY+ +PE + EG Y
Sbjct: 224 ENILHRDLKTANVFLNRRGIVKIGDFGI-SKIMNTKIHAQTVLGTPYYFSPE-MCEGKEY 281
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITK----SKPPRLEGREYSQPLKEFI 246
D K DIW+LG E+ + A +++TK + P G Y+ L+ +
Sbjct: 282 DNKSDIWALGCILGEMCCLKKTFA---ASNLSELVTKIMAGNYTPVPSG--YTSGLRSLM 336
Query: 247 ALCLDEDPKERPYAEEL 263
+ L + RP A E+
Sbjct: 337 SNLLQVEAPRRPTASEV 353
>Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase
Length = 809
Score = 116 bits (290), Expect = 2e-25
Identities = 82/255 (32%), Positives = 135/255 (52%), Gaps = 15/255 (5%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVK---TQQVYAIKVLN---LDNTEDEVEDIRKEIQFLSSL 69
F+ +++G G +G V+ + T ++YA+KVL + E R E Q L +
Sbjct: 49 FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHI 108
Query: 70 KQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISI 128
+Q+P + + ++ +TKL +I++Y GG L T L + E + + + EI++AL +
Sbjct: 109 RQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHL 168
Query: 129 HRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKR-QTMAGTPYWMAPEVIMEG 187
H+ +I+RDIK NIL+ +NG V L DFG++ + +R + GT +MAP+++ G
Sbjct: 169 HKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGG 228
Query: 188 -VYYDTKVDIWSLGITAYEIATGNPPYC----HMEAIRAMQMITKSKPPRLEGREYSQPL 242
+D VD WSLG+ YE+ TG P+ + I KS+PP +E S
Sbjct: 229 DSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPP--YPQEMSALA 286
Query: 243 KEFIALCLDEDPKER 257
K+ I L +DPK+R
Sbjct: 287 KDLIQRLLMKDPKKR 301
Score = 85.1 bits (209), Expect = 5e-16
Identities = 70/250 (28%), Positives = 112/250 (44%), Gaps = 20/250 (8%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G F + K H K+ Q +K+++ + + +KEI L + PNI +
Sbjct: 432 LGEGSFSICRKCVHKKSNQALQVKIIS----KRMEANTQKEITALKLCEGHPNIVKLHEV 487
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALISIHRDNVIHRDIKA 140
+ +++ME GG L LR E IMR+++ AL +H V+HRD+K
Sbjct: 488 FHDQLHTFLVMELLNGGELFDALRKKKHFSETEASYIMRKLVSALSHMHDLGVVHRDLKP 547
Query: 141 ANILIA---NNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIW 197
N+L +N +K+ DFG A +T T + PE++ + YD D+W
Sbjct: 548 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHSCRPELLNQN-GYDESCDLW 606
Query: 198 SLGITAYEIATGNPPYCHME-------AIRAMQMITKSKPPRLEG---REYSQPLKEFIA 247
SLG+ Y + +G P+ + A+ M+ I K EG + SQ K+ I
Sbjct: 607 SLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKG-DFSFEGEAWKNVSQEAKDLIQ 665
Query: 248 LCLDEDPKER 257
L DP +R
Sbjct: 666 GLLTVDPNKR 675
>At4g04700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 347
Score = 115 bits (289), Expect = 3e-25
Identities = 80/259 (30%), Positives = 127/259 (48%), Gaps = 21/259 (8%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEV--EDIRKEIQFLSSLKQTPNITH 77
E +GRG FG+ K T + +A K + +DE ED+++EI+ + L PNI
Sbjct: 32 EELGRGNFGLTRKCVEKSTGKTFACKTILKTKLKDEECEEDVKREIRIMKQLSGEPNIVE 91
Query: 78 YYGSYLIDTKLWVIMEYCAGGSLRTLLRP-----GIIEEKYIGVIMREILVALISIHRDN 132
+ +Y + ++MEYC GG L + EK I+R I+ + + H
Sbjct: 92 FKNAYEDKDSVHIVMEYCGGGELYDKILALYDVGKSYSEKEAAGIIRSIVNVVKNCHYMG 151
Query: 133 VIHRDIKAANILIA---NNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVY 189
V+HRD+K N L+ +N +VK+ DFG + + + + Q +AG+ Y++APEV+
Sbjct: 152 VMHRDLKPENFLLTSNDDNATVKVIDFGCSVFIEEGKV-YQDLAGSDYYIAPEVLQGN-- 208
Query: 190 YDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL- 248
Y + DIWS GI Y + G P+ QM + K ++ E PL++ A+
Sbjct: 209 YGKEADIWSAGIILYILLCGKSPFVKEP---EGQMFNEIKSLEIDYSEEPWPLRDSRAIH 265
Query: 249 ----CLDEDPKERPYAEEL 263
LD +PKER A E+
Sbjct: 266 LVKRMLDRNPKERISAAEV 284
>At3g20410 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 541
Score = 115 bits (289), Expect = 3e-25
Identities = 83/290 (28%), Positives = 145/290 (49%), Gaps = 20/290 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTPNITHYY 79
+GRG+FGV Y T + YA K ++ T+ + +D+R+EIQ + L PNI +
Sbjct: 97 LGRGQFGVTYLCTENSTGKKYACKSISKKKLVTKADKDDMRREIQIMQHLSGQPNIVEFK 156
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G+Y + + ++ME CAGG L ++ G E+ + R+I+ + H V+HRD+
Sbjct: 157 GAYEDEKAVNLVMELCAGGELFDRIIAKGHYTERAAASVCRQIVNVVKICHFMGVLHRDL 216
Query: 139 KAANILIANNGS---VKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L+++ +K DFG++ + + + R + G+ Y++APEV+ Y +VD
Sbjct: 217 KPENFLLSSKDEKALIKATDFGLSVFIEEGKVYRD-IVGSAYYVAPEVLRR--RYGKEVD 273
Query: 196 IWSLGITAYEIATGNPPYCH------MEAIRAMQMITKSKPPRLEGREYSQPLKEFIALC 249
IWS GI Y + +G PP+ +AI + +S+P S K+ +
Sbjct: 274 IWSAGIILYILLSGVPPFWAETEKGIFDAILEGHIDFESQP----WPSISSSAKDLVRRM 329
Query: 250 LDEDPKERPYAEELFKSKLIKQ-EKGTSTVILKELITRYLLFREKNEQYK 298
L DPK R A ++ + +++ + + I +++R FR N+ K
Sbjct: 330 LTADPKRRISAADVLQHPWLREGGEASDKPIDSAVLSRMKQFRAMNKLKK 379
>At2g34180 [T] KOG0583 Serine/threonine protein kinase
Length = 502
Score = 115 bits (289), Expect = 3e-25
Identities = 90/310 (29%), Positives = 148/310 (47%), Gaps = 19/310 (6%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE--VEDIRKEIQFLSSLKQTPNITH 77
+++G G F VY A ++ + + AIKV++ + I++EI L ++ P I H
Sbjct: 61 KLLGHGSFAKVYLARNIHSGEDVAIKVIDKEKIVKSGLAGHIKREISILRRVRH-PYIVH 119
Query: 78 YYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
TK++++MEY GG L + G + E ++++ ++ H V HRD
Sbjct: 120 LLEVMATKTKIYIVMEYVRGGELYNTVARGRLREGTARRYFQQLISSVAFCHSRGVYHRD 179
Query: 138 IKAANILIANNGSVKLCDFG---VAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
+K N+L+ + G+VK+ DFG V+ QL Q + QT GTP ++APEV+ Y K
Sbjct: 180 LKLENLLLDDKGNVKVSDFGLSVVSEQLKQEGI-CQTFCGTPAYLAPEVLTRKGYEGAKA 238
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGREYSQPLKEFIALCLDE 252
DIWS G+ + + G P+ + I K K P+ +S L + LD
Sbjct: 239 DIWSCGVILFVLMAGYLPFDDKNILVMYTKIYKGQFKCPKW----FSPELARLVTRMLDT 294
Query: 253 DPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNPN 312
+P R E+ K + K KG V K I L RE ++ +++S + S +
Sbjct: 295 NPDTRITIPEIMKHRWFK--KGFKHV--KFYIENDKLCREDDD--NDDDDSSSLSSGRSS 348
Query: 313 SSIEGNASQD 322
++ EG+A D
Sbjct: 349 TASEGDAEFD 358
>SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 683
Score = 115 bits (288), Expect = 3e-25
Identities = 78/256 (30%), Positives = 131/256 (50%), Gaps = 14/256 (5%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQ--QVYAIKVLNLDNTEDEVEDIRK--EIQFLSSLKQ 71
+ R + IG G F + F VK +YA KV+ + +++ ++ EI+ S+
Sbjct: 41 YTRYDCIGEGGFA---RCFRVKDNYGNIYAAKVIAKRSLQNDKTKLKLFGEIKVHQSMSH 97
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALISIHR 130
PNI + + T +++I+E C SL LLR + E + +M +IL AL +H+
Sbjct: 98 -PNIVGFIDCFEDSTNIYLILELCEHKSLMELLRKRKQLTEPEVRYLMMQILGALKYMHK 156
Query: 131 DNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM---EG 187
VIHRD+K NI++ + +VK+ DFG+AA L ++ T+ GTP ++APE++ EG
Sbjct: 157 KRVIHRDLKLGNIMLDESNNVKIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEG 216
Query: 188 VYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIA 247
+ +VD+WS G+ Y + G PP+ E + I + + S K+ I+
Sbjct: 217 --HSFEVDLWSAGVVMYALLIGKPPFQDKEVKTIYRKIKANSYSFPSNVDISAEAKDLIS 274
Query: 248 LCLDEDPKERPYAEEL 263
L DP RP +++
Sbjct: 275 SLLTHDPSIRPSIDDI 290
>Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 576
Score = 115 bits (288), Expect = 3e-25
Identities = 77/274 (28%), Positives = 143/274 (52%), Gaps = 18/274 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
++ +IG G F VV + H +T+Q YA+K+++ + + + + EI + SL PNI
Sbjct: 284 YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSH-PNI 342
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALISIHRDNVI 134
+ Y D ++++I+EY GG L + + E +++ ++ AL+ +H +++
Sbjct: 343 VKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIV 402
Query: 135 HRDIKAANILIANN----GSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYY 190
HRD+K N+L+ N ++KL DFG+A + + + T+ GTP ++APE++ E Y
Sbjct: 403 HRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIF---TVCGTPTYVAPEILSE-KGY 458
Query: 191 DTKVDIWSLGITAYEIATGNPPY-----CHMEAIRAMQM-ITKSKPPRLEGREYSQPLKE 244
+VD+W+ G+ Y + G PP+ E +Q+ + PP + S K+
Sbjct: 459 GLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWD--NISDAAKD 516
Query: 245 FIALCLDEDPKERPYAEELFKSKLIKQEKGTSTV 278
++ L DPK+R A ++ + I+ T+TV
Sbjct: 517 LVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTV 550
>At2g31500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 582
Score = 115 bits (288), Expect = 3e-25
Identities = 74/267 (27%), Positives = 131/267 (48%), Gaps = 11/267 (4%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTPNITHYY 79
+GRG+FGV ++ + T++ +A K ++ + TE +VED+R+E++ + L + PNI +
Sbjct: 72 LGRGEFGVTHECIEISTRERFACKRISKEKLRTEIDVEDVRREVEIMRCLPKHPNIVSFK 131
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
++ ++++ME C GG L ++ G E+ + + IL + H VIHRD+
Sbjct: 132 EAFEDKDAVYLVMEICEGGELFDRIVSRGHYTERAAASVAKTILEVVKVCHEHGVIHRDL 191
Query: 139 KAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L +N +K DFG++ + + + G+PY+MAPEV+ Y ++D
Sbjct: 192 KPENFLFSNGTETAQLKAIDFGLSIFFKPAQ-RFNEIVGSPYYMAPEVLRRN--YGPEID 248
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKP--PRLEGREYSQPLKEFIALCLDED 253
+WS G+ Y + G PP+ I + R + S KE + LD +
Sbjct: 249 VWSAGVILYILLCGVPPFWAETEEGIAHAIVRGNIDFERDPWPKVSHEAKELVKNMLDAN 308
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVIL 280
P R +E+ + I+ + V L
Sbjct: 309 PYSRLTVQEVLEHPWIRNAERAPNVNL 335
>SPACUNK12.02c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 335
Score = 115 bits (287), Expect = 5e-25
Identities = 73/270 (27%), Positives = 131/270 (48%), Gaps = 13/270 (4%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLK-QTPNITHYY 79
++G G + V +A H++T ++YA K++N E + + ++ EI L + + PNI H
Sbjct: 36 VLGGGTYATVREAVHIETNKMYAAKIMNKKMMEKKQDFVKNEIAILKRVSYEHPNILHLV 95
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
+ L++I E GG L + G E +MR A+ +H + ++HRD+
Sbjct: 96 DFFETVNNLYLITELATGGELFDRICAKGSFYEADAAALMRTTTSAVKYLHDNGIVHRDL 155
Query: 139 KAANILIAN---NGSVKLCDFGVAAQLSQSM-LKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
K N+L + N + + DFG++ S T GTP +MAPEV Y V
Sbjct: 156 KPENLLYRSKDPNSDLLIADFGLSHFYEDSQYYMLMTACGTPEYMAPEVFRR-TGYGKPV 214
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSK----PPRLEGREYSQPLKEFIALCL 250
D+W++G+ Y + +G P+ + ++ I ++ P G S+ K+FI CL
Sbjct: 215 DMWAIGVITYFLLSGYTPFARPSQVEVIEAILANEYTFNDPCWSG--ISETAKDFIKKCL 272
Query: 251 DEDPKERPYAEELFKSKLIKQEKGTSTVIL 280
+ DP +R A + K + +++ ++ +L
Sbjct: 273 ENDPSKRLTAADALKHPFLSEKRPATSNLL 302
>At5g01810 [T] KOG0583 Serine/threonine protein kinase
Length = 421
Score = 115 bits (287), Expect = 5e-25
Identities = 96/366 (26%), Positives = 172/366 (46%), Gaps = 37/366 (10%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTPNITH 77
+ +G+G F VY A H+KT AIKV++ + E I++EI + L+ PNI
Sbjct: 16 KFLGQGTFAKVYHARHLKTGDSVAIKVIDKERILKVGMTEQIKREISAMRLLRH-PNIVE 74
Query: 78 YYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
+ +K++ +ME+ GG L + G + E ++++ A+ H V HRD
Sbjct: 75 LHEVMATKSKIYFVMEHVKGGELFNKVSTGKLREDVARKYFQQLVRAVDFCHSRGVCHRD 134
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQ-----TMAGTPYWMAPEVIMEGVYYDT 192
+K N+L+ +G++K+ DFG++A LS S +RQ T GTP ++APEVI Y
Sbjct: 135 LKPENLLLDEHGNLKISDFGLSA-LSDS--RRQDGLLHTTCGTPAYVAPEVISRNGYDGF 191
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP-LKEFIALCLD 251
K D+WS G+ + + G P+ + + I K++ ++ + P K + LD
Sbjct: 192 KADVWSCGVILFVLLAGYLPFRDSNLMELYKKIGKAE---VKFPNWLAPGAKRLLKRILD 248
Query: 252 EDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSKQNP 311
+P R E++ KS + KG + + + E+ + E E + S+++
Sbjct: 249 PNPNTRVSTEKIMKSSWFR--KGLQEEVKESV--------EEETEVDAEAEGNASAEKEK 298
Query: 312 NSSIEGNASQ--------DAGSFTEKEPEDIDIKWDFDSLSSR--EYILE--NDINVEAI 359
I NA + D EK E ++++ + +S E ++E D+ ++
Sbjct: 299 KRCINLNAFEIISLSTGFDLSGLFEKGEEKEEMRFTSNREASEITEKLVEIGKDLKMKVR 358
Query: 360 PEEADW 365
+E +W
Sbjct: 359 KKEHEW 364
>At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 471
Score = 115 bits (287), Expect = 5e-25
Identities = 82/265 (30%), Positives = 135/265 (50%), Gaps = 18/265 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTP 73
F+ +++G+G FG VY+ T ++YA+KV+ D ++ E ++ E L+ + P
Sbjct: 140 FEVLKVVGQGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNHAEYMKAERDILTKIDH-P 198
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLR-TLLRPGIIEEKYIGVIMREILVALISIHRDN 132
I S+ +L++++++ GG L L G+ E V EI+ A+ +H
Sbjct: 199 FIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKG 258
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
++HRD+K NIL+ +G V L DFG+A + ++ + +M GT +MAPE++ G +D
Sbjct: 259 IMHRDLKPENILMDVDGHVMLTDFGLAKEFEEN-TRSNSMCGTTEYMAPEIV-RGKGHDK 316
Query: 193 KVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGREYSQPLKEFIALCL 250
D WS+GI YE+ TG PP+ + + Q I K K P+ E LK L
Sbjct: 317 AADWWSVGILLYEMLTGKPPFLGSKG-KIQQKIVKDKIKLPQFLSNEAHALLKGL----L 371
Query: 251 DEDPKER-----PYAEELFKSKLIK 270
++P+ R AEE+ K K K
Sbjct: 372 QKEPERRLGSGPSGAEEIKKHKWFK 396
>CE27573 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1420
Score = 114 bits (286), Expect = 6e-25
Identities = 81/259 (31%), Positives = 123/259 (47%), Gaps = 18/259 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
I G FG V++A + + +V A KV+ + + I EI L N+ YYG
Sbjct: 1131 IASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKA--IESEINIFRQLIHE-NLVKYYGV 1187
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
+ D+ + + MEYC+ G+L + G ++ K + +L A+ +H +IHRDIK A
Sbjct: 1188 QVEDSDVIIFMEYCSQGTLERICH-GKMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPA 1246
Query: 142 NILIANNGSVKLCDFGVAAQLSQSML---KRQTMAGTPYWMAPEVIMEGVY--------- 189
NI + +KL DFG +++L +S + QT AGTP +MAPE+ G
Sbjct: 1247 NIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSG 1306
Query: 190 YDTKVDIWSLGITAYEIATGNPPY--CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIA 247
Y VDIW+LG T + TG P+ I K KP + + +K F
Sbjct: 1307 YGRSVDIWALGATVVNMMTGKVPFEGQTRHQIAFALCFRKQKPTYPDIADKRPDVKRFFD 1366
Query: 248 LCLDEDPKERPYAEELFKS 266
C + P +RP A EL ++
Sbjct: 1367 NCFEFLPNDRPTAAELLQT 1385
>CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 856
Score = 114 bits (286), Expect = 6e-25
Identities = 80/265 (30%), Positives = 133/265 (50%), Gaps = 19/265 (7%)
Query: 16 FKRKEIIGRGKFGVVYKAFHV-KTQQVYAIKVLNLDNTEDEVEDIRKEIQFL---SSLKQ 71
+ +++++G G F +VY+ +V +T AIK + N + KEI+ L SSLK
Sbjct: 9 YSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSKNLLTKEIKILKELSSLKH 68
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALISIHR 130
N+ T ++++ME+C GG L L+ + E I + +I AL +I++
Sbjct: 69 E-NLVGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQIAHALEAINK 127
Query: 131 DNVIHRDIKAANILIANNGS----------VKLCDFGVAAQLSQSMLKRQTMAGTPYWMA 180
++HRD+K NIL+ NN +KL DFG A L+ ++ T+ G+P +MA
Sbjct: 128 KGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVM-AATLCGSPMYMA 186
Query: 181 PEVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQ 240
PEVIM + YD K D+WS+G ++ TG P+ + K++ R E+
Sbjct: 187 PEVIM-SMQYDAKADLWSIGTILFQCLTGKAPFVAQTPPQLKAYYEKTRELRPNIPEWCS 245
Query: 241 P-LKEFIALCLDEDPKERPYAEELF 264
P L++ + L + K+R E+ F
Sbjct: 246 PNLRDLLLRLLKRNAKDRISFEDFF 270
>CE07737 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1418
Score = 114 bits (286), Expect = 6e-25
Identities = 81/259 (31%), Positives = 123/259 (47%), Gaps = 18/259 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
I G FG V++A + + +V A KV+ + + I EI L N+ YYG
Sbjct: 1131 IASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKA--IESEINIFRQLIHE-NLVKYYGV 1187
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
+ D+ + + MEYC+ G+L + G ++ K + +L A+ +H +IHRDIK A
Sbjct: 1188 QVEDSDVIIFMEYCSQGTLERICH-GKMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPA 1246
Query: 142 NILIANNGSVKLCDFGVAAQLSQSML---KRQTMAGTPYWMAPEVIMEGVY--------- 189
NI + +KL DFG +++L +S + QT AGTP +MAPE+ G
Sbjct: 1247 NIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSG 1306
Query: 190 YDTKVDIWSLGITAYEIATGNPPY--CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIA 247
Y VDIW+LG T + TG P+ I K KP + + +K F
Sbjct: 1307 YGRSVDIWALGATVVNMMTGKVPFEGQTRHQIAFALCFRKQKPTYPDIADKRPDVKRFFD 1366
Query: 248 LCLDEDPKERPYAEELFKS 266
C + P +RP A EL ++
Sbjct: 1367 NCFEFLPNDRPTAAELLQT 1385
>At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 284
Score = 114 bits (286), Expect = 6e-25
Identities = 79/259 (30%), Positives = 127/259 (48%), Gaps = 9/259 (3%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVED--IRKEIQFLSSLKQTPNITH 77
E IGRG+FG V + + T +A K ++ + D+++ + E + ++ L PNI
Sbjct: 19 EEIGRGRFGTVSRVYAPATGDFFACKTIDKASLSDDLDRACLDNEPKLMALLSYHPNIVQ 78
Query: 78 YYGSYLIDTKLWVIME--YCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIH 135
+ D+ L + ME + + L+ G E ++IL AL HR V+H
Sbjct: 79 IHDLIDTDSTLSIFMELVHPSVSIYDRLVSSGTFFEPQTASFAKQILQALSHCHRYGVVH 138
Query: 136 RDIKAANILI-ANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
RDIK NIL+ N +VK+CDFG L + + + GTPY++APEV+M G Y KV
Sbjct: 139 RDIKPENILVDLRNDTVKICDFGSGIWLGEGETT-EGVVGTPYYVAPEVLM-GYSYGEKV 196
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS--KPPRLEGREYSQPLKEFIALCLDE 252
D+WS G+ Y + G PP+ A + + + + P R S K+F+ + +
Sbjct: 197 DLWSAGVVLYTMLAGTPPFYGETAEEIFEAVLRGNLRFPTKIFRGVSSMAKDFLRKLICK 256
Query: 253 DPKERPYAEELFKSKLIKQ 271
D R AE+ + I++
Sbjct: 257 DASRRFSAEQALRHPWIQR 275
>7299322 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 434
Score = 114 bits (286), Expect = 6e-25
Identities = 76/266 (28%), Positives = 132/266 (49%), Gaps = 12/266 (4%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVE--DIRKEIQFLSSLKQTPNITHYY 79
+G+G +G V + +T Q AIK + E E + IR+E+Q +SS+ PNI H Y
Sbjct: 88 LGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHH-PNIIHIY 146
Query: 80 GSYLIDTKLWVIMEYCAGGSLRTLLRPG-IIEEKYIGVIMREILVALISIHRDNVIHRDI 138
+ K+ ++ME+ AGG L L ++ E+ I R++ A+ H+ + HRD+
Sbjct: 147 EVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICHRDL 206
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K NIL+ G+ K+ DFG++ L T G+P + +PE++ Y +VD WS
Sbjct: 207 KLENILLDEKGNAKIADFGLSNVFDDQRL-LGTFCGSPLYASPEIVEGTPYQGPEVDCWS 265
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKSK--PPRLEGREYSQPLKEFIALCLDEDPKE 256
LG+ Y + G+ P+ R ++ I++ PR R S +++ + +C P++
Sbjct: 266 LGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPSRA-STLIRDMLTVC----PRK 320
Query: 257 RPYAEELFKSKLIKQEKGTSTVILKE 282
R E++ + + S + L E
Sbjct: 321 RASIEQICSHWWVNENDNVSCLDLAE 346
>Hs4759044 [T] KOG0612 Rho-associated coiled-coil containing protein kinase
Length = 1388
Score = 114 bits (285), Expect = 8e-25
Identities = 87/329 (26%), Positives = 163/329 (49%), Gaps = 40/329 (12%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRK-------EIQFLSSLKQT 72
++IGRG FG V H +Q+VYA+K+L+ + E I++ E + + + +
Sbjct: 96 KVIGRGAFGEVQLVRHKASQKVYAMKLLS------KFEMIKRSDSAFFWEERDIMAFANS 149
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDN 132
P + + ++ D L+++MEY GG L L+ + EK+ E+++AL +IH
Sbjct: 150 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMG 209
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQS-MLKRQTMAGTPYWMAPEVIME---GV 188
+IHRD+K N+L+ +G +KL DFG ++ ++ M+ T GTP +++PEV+
Sbjct: 210 LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDG 269
Query: 189 YYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL 248
+Y + D WS+G+ YE+ G+ P+ + YS+ + +L
Sbjct: 270 FYGRECDWWSVGVFLYEMLVGDTPFYADSLVGT----------------YSKIMDHKNSL 313
Query: 249 CLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSK 308
C ED + +A+ L + L +E ++E I ++ F KN+Q+ + T++
Sbjct: 314 CFPEDAEISKHAKNLICAFLTDREVRLGRNGVEE-IRQHPFF--KNDQWHWDNIRETAAP 370
Query: 309 QNPNSSIEGNASQDAGSFTEKEPEDIDIK 337
P E ++ D+ +F + E + D++
Sbjct: 371 VVP----ELSSDIDSSNFDDIEDDKGDVE 395
>Hs20536595 [T] KOG0612 Rho-associated coiled-coil containing protein kinase
Length = 1388
Score = 114 bits (285), Expect = 8e-25
Identities = 87/329 (26%), Positives = 163/329 (49%), Gaps = 40/329 (12%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRK-------EIQFLSSLKQT 72
++IGRG FG V H +Q+VYA+K+L+ + E I++ E + + + +
Sbjct: 96 KVIGRGAFGEVQLVRHKASQKVYAMKLLS------KFEMIKRSDSAFFWEERDIMAFANS 149
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDN 132
P + + ++ D L+++MEY GG L L+ + EK+ E+++AL +IH
Sbjct: 150 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMG 209
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQS-MLKRQTMAGTPYWMAPEVIME---GV 188
+IHRD+K N+L+ +G +KL DFG ++ ++ M+ T GTP +++PEV+
Sbjct: 210 LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDG 269
Query: 189 YYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL 248
+Y + D WS+G+ YE+ G+ P+ + YS+ + +L
Sbjct: 270 FYGRECDWWSVGVFLYEMLVGDTPFYADSLVGT----------------YSKIMDHKNSL 313
Query: 249 CLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSK 308
C ED + +A+ L + L +E ++E I ++ F KN+Q+ + T++
Sbjct: 314 CFPEDAEISKHAKNLICAFLTDREVRLGRNGVEE-IRQHPFF--KNDQWHWDNIRETAAP 370
Query: 309 QNPNSSIEGNASQDAGSFTEKEPEDIDIK 337
P E ++ D+ +F + E + D++
Sbjct: 371 VVP----ELSSDIDSSNFDDIEDDKGDVE 395
>CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 422
Score = 114 bits (285), Expect = 8e-25
Identities = 76/239 (31%), Positives = 125/239 (51%), Gaps = 6/239 (2%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTPNITHYY 79
IG+G FG VY+ H +T+++YA+K+L+ ++ ++EV+ + E L + + P + +
Sbjct: 100 IGKGSFGRVYQVRHKETKKIYAMKILSKEHIRKKNEVKHVMAERNVLINNFKHPFLVSLH 159
Query: 80 GSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
S+ KL+ ++++ GG L + L R E EI AL +H N+I+RD+
Sbjct: 160 FSFQNKEKLYFVLDHLNGGELFSHLQREKHFSESRSRFYAAEIACALGYLHEKNIIYRDL 219
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K N+L+ + G + L DFG+ + Q T GTP ++APE+I++ YD VD W
Sbjct: 220 KPENLLLDDKGYLVLTDFGLCKEDMQGSKTTSTFCGTPEYLAPEIILKKP-YDKTVDWWC 278
Query: 199 LGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKER 257
LG YE+ G PP+ + I ++P RL+ S P E I L +D +R
Sbjct: 279 LGSVLYEMIFGLPPFYSKDHNEMYDKII-NQPLRLK-HNISVPCSELITGLLQKDRSKR 335
>At4g21940 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 554
Score = 114 bits (285), Expect = 8e-25
Identities = 81/285 (28%), Positives = 135/285 (46%), Gaps = 11/285 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIK-VLNLDNT-EDEVEDIRKEIQFLSSLKQTPNITHYY 79
+GRG+FG+ Y T YA K +L T + +++D+++EIQ + L NI
Sbjct: 108 LGRGQFGITYTCKENSTGNTYACKSILKRKLTRKQDIDDVKREIQIMQYLSGQENIVEIK 167
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
G+Y + ++ME C G L ++ G EK ++R +L + H VIHRD+
Sbjct: 168 GAYEDRQSIHLVMELCGGSELFDRIIAQGHYSEKAAAGVIRSVLNVVQICHFMGVIHRDL 227
Query: 139 KAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L+A+ N +K DFG++ + + + R + G+ Y++APEV+ Y ++D
Sbjct: 228 KPENFLLASTDENAMLKATDFGLSVFIEEGKVYRD-IVGSAYYVAPEVLRRS--YGKEID 284
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKP--PRLEGREYSQPLKEFIALCLDED 253
IWS GI Y + G PP+ I K + S+ K+ + L +D
Sbjct: 285 IWSAGIILYILLCGVPPFWSETEKGIFNEIIKGEIDFDSQPWPSISESAKDLVRKLLTKD 344
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYK 298
PK+R A + + I+ + I +++R FR N+ K
Sbjct: 345 PKQRISAAQALEHPWIRGGEAPDKPIDSAVLSRMKQFRAMNKLKK 389
>7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1612
Score = 114 bits (285), Expect = 8e-25
Identities = 79/258 (30%), Positives = 132/258 (50%), Gaps = 11/258 (4%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDE-VEDIRKEIQFLSSLKQTPNITHYYG 80
IG+G+FG VY A + T ++ A+K + + E ++++ +E++ L +K N+ YYG
Sbjct: 1329 IGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHK-NLVRYYG 1387
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIHRDNVIHRDIK 139
+ +L + ME C+ G+L +L+ G + E ++L + +H+ ++HRDIK
Sbjct: 1388 IEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIK 1447
Query: 140 AANI-LIANNGSVKLCDFGVAAQLSQSML---KRQTMAGTPYWMAPEVIME--GVYYDTK 193
ANI L+ + S+KL DFG A ++ + Q GT +MAPEV + +
Sbjct: 1448 TANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRA 1507
Query: 194 VDIWSLGITAYEIATGNPPYCHMEA-IRAMQMITKSKPPRLEGREYSQPLKEFIALCLDE 252
DIWS+G E+A+G P+ ++ + M + + P+ SQ +FI CL
Sbjct: 1508 ADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAP-ESLSQEGHDFIDHCLQH 1566
Query: 253 DPKERPYAEELFKSKLIK 270
DPK R A EL + K
Sbjct: 1567 DPKRRLTAVELLEHNFCK 1584
>SPAC22E12.14c [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 646
Score = 114 bits (284), Expect = 1e-24
Identities = 78/244 (31%), Positives = 128/244 (51%), Gaps = 8/244 (3%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLN---LDNTEDEVEDI-RKEIQFLSSLKQTPNI 75
++IG+G FG VY T++VYA+KVL+ + ++ + ++I +S +P I
Sbjct: 270 KLIGKGTFGQVYLVRKKDTERVYAMKVLSKKVIVRRKEVAHTVGERDILVQTSAADSPFI 329
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGI-IEEKYIGVIMREILVALISIHRDNVI 134
S+ L+++ +Y AGG L L+ + E+ + E+L+AL ++H+ ++
Sbjct: 330 VALRFSFQTPKDLYLVTDYMAGGELFWHLQKSVRFPEERAKFYIAELLLALQALHKRGIV 389
Query: 135 HRDIKAANILIANNGSVKLCDFGVA-AQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
+RD+K NIL+ G + LCDFG++ A LS R T GT ++APEVI++ YD
Sbjct: 390 YRDLKPENILLDVQGHIALCDFGLSKANLSVGTTTR-TFCGTTDYLAPEVILDEAGYDMM 448
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDED 253
VD WSLG+ YE+ G P+ + + I K R S ++ I L L+ +
Sbjct: 449 VDFWSLGVLLYEMTCGWSPFYADNTQQLYKNIVFGK-VRFPRGLLSVEARDLIKLLLNRN 507
Query: 254 PKER 257
PK R
Sbjct: 508 PKHR 511
>SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 722
Score = 114 bits (284), Expect = 1e-24
Identities = 99/359 (27%), Positives = 164/359 (45%), Gaps = 39/359 (10%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDN-TEDEVEDIRKEIQFLSSLKQTPN 74
+K E IG G FG +YK +K + A K ++ N T E + I E+ L +LK PN
Sbjct: 4 YKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQYIADEVNILRNLKH-PN 62
Query: 75 ITHYYGSYLIDTK--LWVIMEYCAGGSLRTLLRPGIIEEKY-----IGVIMREILVALIS 127
I Y G L + + + MEYC G L L++ E+K + ++L+AL
Sbjct: 63 IVQYCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYR 122
Query: 128 IH-------------------RDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLK 168
H + +V+HRDIK ANI + N SVKL DFG++ L + +
Sbjct: 123 CHYGENAPACDSQWPREIFHPKQSVLHRDIKPANIFLDENNSVKLGDFGLSKLLDNTRVF 182
Query: 169 RQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKS 228
Q+ GTPY+M+PE+I Y K D+W+LG +EI P+ + + I +
Sbjct: 183 TQSYVGTPYYMSPEIIRSSP-YSAKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQG 241
Query: 229 KPPRLEGREYSQPLKEFIALCLDEDPKERPYAEELFKSKL---IKQEKGTSTVILKELIT 285
+ YS + I CL+ + RP +L +S + I+ + + V+L++
Sbjct: 242 NLSCWD-HHYSDDVFLLIRHCLEVNSDLRPTTYQLLRSPILSDIRSKLESERVVLEQSDL 300
Query: 286 -----RYLLFREKNEQYKHEEESHTSSK-QNPNSSIEGNASQDAGSFTEKEPEDIDIKW 338
+ L+ E + Q++ + S S+ +N +S + EK+ D+D ++
Sbjct: 301 LHKKHQMLIQLENDLQFREQRLSARESELENVIASRLAQREEILRRELEKQLRDMDARY 359
>CE23001 [R] KOG0589 Serine/threonine protein kinase
Length = 579
Score = 114 bits (284), Expect = 1e-24
Identities = 74/255 (29%), Positives = 132/255 (51%), Gaps = 8/255 (3%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIR-KEIQFLSSLKQTPN 74
++R +G+G FG + + IK +N+ + + + E+ LS ++ PN
Sbjct: 171 YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEH-PN 229
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRTLLR--PGIIEEKYIGVIMREILVALISIHRDN 132
I YY S+ + L + MEY GG+L +L +++E+ IG +M ++ A+ +H ++
Sbjct: 230 IIAYYDSFEEEGVLMIEMEYADGGTLAQMLSRTQNLLDEEQIGDMMIQMCSAVAYLHENS 289
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKR--QTMAGTPYWMAPEVIMEGVYY 190
V+HRD+K AN+ + + VK+ DFG++ + L + +T+ GTPY+++PE + GV Y
Sbjct: 290 VLHRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPE-MCSGVSY 348
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
+ K D+W+LG YE+ + + I ++G YS +K I L
Sbjct: 349 NEKSDMWALGCILYEMCCLKKAFEGDNLPALVNSIMTCAYTPVKG-PYSAEMKMVIRELL 407
Query: 251 DEDPKERPYAEELFK 265
DP++RP A + K
Sbjct: 408 QLDPQKRPSAPQALK 422
>At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 307
Score = 114 bits (284), Expect = 1e-24
Identities = 77/265 (29%), Positives = 135/265 (50%), Gaps = 15/265 (5%)
Query: 17 KRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNIT 76
++ ++GRG G+VYK H T ++YA+K +N D + + +E++ L +P +
Sbjct: 46 EKLHVLGRGSSGIVYKVHHKTTGEIYALKSVNGDMSPAFTRQLAREMEILRRT-DSPYVV 104
Query: 77 HYYGSYL--IDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
G + I ++ ++MEY GG+L +L G + EK + R+IL L +H ++
Sbjct: 105 RCQGIFEKPIVGEVSILMEYMDGGNLESLR--GAVTEKQLAGFSRQILKGLSYLHSLKIV 162
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIK AN+L+ + VK+ DFGV+ +++S+ + GT +M+PE ++ V
Sbjct: 163 HRDIKPANLLLNSRNEVKIADFGVSKIITRSLDYCNSYVGTCAYMSPERFDSAAGENSDV 222
Query: 195 ---DIWSLGITAYEIATGNPPYC----HMEAIRAMQMITKSKPPRL-EGREYSQPLKEFI 246
DIWS G+ E+ G+ P + M ++ +PPR EG S + F+
Sbjct: 223 YAGDIWSFGVMILELFVGHFPLLPQGQRPDWATLMCVVCFGEPPRAPEG--CSDEFRSFV 280
Query: 247 ALCLDEDPKERPYAEELFKSKLIKQ 271
CL ++ ER A +L +++
Sbjct: 281 DCCLRKESSERWTASQLLGHPFLRE 305
>7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 835
Score = 114 bits (284), Expect = 1e-24
Identities = 95/367 (25%), Positives = 165/367 (44%), Gaps = 55/367 (14%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+ K+++G G F VVYK H K AIK + + KEI+ L L + +
Sbjct: 9 YSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKELTE---L 65
Query: 76 THYYGSYLIDTK-----LWVIMEYCAGGSLRTLLR-PGIIEEKYIGVIMREILVALISIH 129
H L+D K + ++MEYC GG L L G + E + + + ++ A+ +++
Sbjct: 66 HHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALY 125
Query: 130 RDNVIHRDIKAANILIANNG----------SVKLCDFGVAAQLSQSMLKRQTMAGTPYWM 179
++HRD+K NIL+++N ++K+ DFG A L++ + T+ G+P +M
Sbjct: 126 TKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAA-TLCGSPMYM 184
Query: 180 APEVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHM--EAIRAMQMITKSKPPRLEGRE 237
APEVIM + YD+K D+WSLG Y+ TG P+ +++ + P++
Sbjct: 185 APEVIMS-LQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPS-G 242
Query: 238 YSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEK------------GTSTVILKELIT 285
S L++ + L + K+R E F + ++ +K GT K +
Sbjct: 243 VSPDLRDLLLCLLRRNSKDRISYESFFVHRFLQGKKAAVSPVDMPPLGGTPPAKAKSPLQ 302
Query: 286 RYL------------LFREKNEQYKHEEESHTSSKQNP-------NSSIEGNASQDAGSF 326
+ L +E+ EQ E+E+ S NP N + ++ ++GS
Sbjct: 303 QQLEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSGSC 362
Query: 327 TEKEPED 333
+ E D
Sbjct: 363 SSHEDSD 369
>YHR205w [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 824
Score = 113 bits (283), Expect = 1e-24
Identities = 79/251 (31%), Positives = 131/251 (51%), Gaps = 16/251 (6%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLN----LDNTEDEVEDIRKEIQFLSSLKQ 71
F+ ++G+G FG VY+ TQ++YA+KVL+ + E + I ++ K
Sbjct: 412 FEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTIGERNILVTTASKS 471
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISIHR 130
+P I S+ T L+++ +Y +GG L L + G E + E+++AL +H
Sbjct: 472 SPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHD 531
Query: 131 DNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLK--RQTMAGTPYWMAPEVIMEGV 188
+++++RD+K NIL+ NG++ LCDFG LS++ LK T GT ++APE++++
Sbjct: 532 NDIVYRDLKPENILLDANGNIALCDFG----LSKADLKDRTNTFCGTTEYLAPELLLDET 587
Query: 189 YYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMIT--KSKPPRLEGREYSQPLKEFI 246
Y VD WSLG+ +E+ G P+ + Q I K K PR SQ + F+
Sbjct: 588 GYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPR---DVLSQEGRSFV 644
Query: 247 ALCLDEDPKER 257
L+ +PK R
Sbjct: 645 KGLLNRNPKHR 655
>CE24941 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 435
Score = 113 bits (283), Expect = 1e-24
Identities = 80/259 (30%), Positives = 136/259 (51%), Gaps = 18/259 (6%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
++G G GVV A ++ A+K + ++ ++ ++ I ++++ +S + +P I YG
Sbjct: 127 LLGSGSCGVVESA--TVRSKLMAVKTMYKNDNKENLKRILRDVRIMS-MCNSPFIVTSYG 183
Query: 81 SYLIDTKLWV---IMEYCAGGSLRTLLRPGI--IEEKYIGVIMREILVALISI-HRDNVI 134
++ D+ + + IM C LR + + E G I+ + AL + + ++I
Sbjct: 184 YFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSII 243
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPE--VIMEGVYYDT 192
HRDIK +NIL ++G+VKLCDFG++ ++ SM ++ AG P +MAPE I YD
Sbjct: 244 HRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKS-AGCPPYMAPERLTIETNSKYDV 302
Query: 193 KVDIWSLGITAYEIATGNPPY----CHMEAIRAMQMITKSKPPRLE--GREYSQPLKEFI 246
+ D+WSLGIT Y++ TG P+ + + + P E R +S EF+
Sbjct: 303 RSDVWSLGITVYQLVTGLYPFPLNDMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFL 362
Query: 247 ALCLDEDPKERPYAEELFK 265
LCL +D +ERP +L K
Sbjct: 363 DLCLRKDVRERPEYRQLMK 381
>CE24761 [D] KOG0580 Serine/threonine protein kinase
Length = 305
Score = 113 bits (283), Expect = 1e-24
Identities = 79/249 (31%), Positives = 126/249 (49%), Gaps = 17/249 (6%)
Query: 22 IGRGKFGVVYKA------FHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
+G+GKFG VY A FHV + ++ ++++ E ++E +EI+ S L PNI
Sbjct: 36 LGKGKFGSVYLARTKTGHFHVAIKVLFKSQLIS-GGVEHQLE---REIEIQSHLNH-PNI 90
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
Y + K+++++EY GG + + L E M EI AL HR NVI
Sbjct: 91 IKLYTYFWDAKKIYLVLEYAPGGEMYKQLTVSKRFSEPTAAKYMYEIADALSYCHRKNVI 150
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRDIK N+LI + G +K+ DFG + + KRQTM GT ++ PE++ G + V
Sbjct: 151 HRDIKPENLLIGSQGELKIGDFGWSVHAPSN--KRQTMCGTMDYLPPEMV-NGADHSDAV 207
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
D+W++G+ YE G PP+ H + + I ++ + + ++ I L DP
Sbjct: 208 DLWAIGVLCYEFLVGKPPFEHEDQSKTYAAIKAARFTYPD--SVKKGARDLIGRLLVVDP 265
Query: 255 KERPYAEEL 263
K R E++
Sbjct: 266 KARCTLEQV 274
>CE15235 [R] KOG0589 Serine/threonine protein kinase
Length = 357
Score = 113 bits (283), Expect = 1e-24
Identities = 81/268 (30%), Positives = 133/268 (49%), Gaps = 18/268 (6%)
Query: 16 FKRKEIIGRGKFGVVY--KAFHVKTQQVYAIKVLNLDN-TEDEVEDIRKEIQFLSSLKQT 72
+++ ++GRG FGV + + + + Q IK++N TE E I+ E+ L + Q
Sbjct: 4 YEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKV-QH 62
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRP----------GIIEEKYIGVIMREIL 122
P I Y S+++D +L ++M+Y GG+L L+ EK + +IL
Sbjct: 63 PLIIGYIDSFIMDNQLGIVMQYAEGGTLERLINDQRAIKDSNMREYFPEKTVLDYFTQIL 122
Query: 123 VALISIHRDNVIHRDIKAANILIANNGSV-KLCDFGVAAQLSQSMLKRQTMAGTPYWMAP 181
+AL +H+ N++HRD+K NIL+ +V KL DFG++ +L + T+ GTP +++P
Sbjct: 123 IALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELG-TKSAASTVIGTPNYLSP 181
Query: 182 EVIMEGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQP 241
E I E Y+ K D+WSLG YE+ + + IT+SK L G S
Sbjct: 182 E-ICESRPYNQKSDMWSLGCVLYELLQLERAFDGENLPAIVMKITRSKQNPL-GDHVSND 239
Query: 242 LKEFIALCLDEDPKERPYAEELFKSKLI 269
+K + L +RP +L L+
Sbjct: 240 VKMLVENLLKTHTDKRPDVSQLLSDPLV 267
>At5g19360 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 523
Score = 113 bits (283), Expect = 1e-24
Identities = 85/287 (29%), Positives = 140/287 (48%), Gaps = 22/287 (7%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVL---NLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
+GRG+FGV + T +A K + L N ED +ED+R+E+Q + L PNI
Sbjct: 74 LGRGQFGVTHLCTQKATGLQFACKTIAKRKLVNKED-IEDVRREVQIMHHLTGQPNIVEL 132
Query: 79 YGSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
G+Y + ++ME CAGG L ++ G E+ ++R I+ + + H VIHRD
Sbjct: 133 KGAYEDKHSVHLVMELCAGGELFDRIIAKGHYSERAAASLLRTIVQIIHTCHSMGVIHRD 192
Query: 138 IKAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
+K N L+ + N +K DFG++ + + + G+ Y++APEV+ Y +
Sbjct: 193 LKPENFLLLSKDENSPLKATDFGLSVFYKPGEVFKD-IVGSAYYIAPEVLRR--KYGPEA 249
Query: 195 DIWSLGITAYEIATGNPPYCH------MEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL 248
DIWS+G+ Y + G PP+ AI + Q+ S P + S K+ +
Sbjct: 250 DIWSIGVMLYILLCGVPPFWAESENGIFNAILSGQVDFSSDPWPV----ISPQAKDLVRK 305
Query: 249 CLDEDPKERPYAEELFKSKLIKQEKGTSTVIL-KELITRYLLFREKN 294
L+ DPK+R A ++ IK++ V L +++R F+ N
Sbjct: 306 MLNSDPKQRLTAAQVLNHPWIKEDGEAPDVPLDNAVMSRLKQFKAMN 352
>At5g12180 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 528
Score = 113 bits (283), Expect = 1e-24
Identities = 85/287 (29%), Positives = 137/287 (47%), Gaps = 22/287 (7%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVL---NLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
+GRG+FGV + T +A K + L N ED +ED+R+E+Q + L PNI
Sbjct: 79 LGRGQFGVTHLCTQKATGHQFACKTIAKRKLVNKED-IEDVRREVQIMHHLTGQPNIVEL 137
Query: 79 YGSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
G+Y + ++ME CAGG L ++ G E+ ++R I+ + + H VIHRD
Sbjct: 138 KGAYEDKHSVHLVMELCAGGELFDRIIAKGHYSERAAASLLRTIVQIVHTCHSMGVIHRD 197
Query: 138 IKAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
+K N L+ N N +K DFG++ + + + G+ Y++APEV+ Y +
Sbjct: 198 LKPENFLLLNKDENSPLKATDFGLSVFYKPGEVFKD-IVGSAYYIAPEVLKR--KYGPEA 254
Query: 195 DIWSLGITAYEIATGNPPYCH------MEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL 248
DIWS+G+ Y + G PP+ AI + S P S K+ +
Sbjct: 255 DIWSIGVMLYILLCGVPPFWAESENGIFNAILRGHVDFSSDP----WPSISPQAKDLVKK 310
Query: 249 CLDEDPKERPYAEELFKSKLIKQEKGTSTVIL-KELITRYLLFREKN 294
L+ DPK+R A ++ IK++ V L +++R F+ N
Sbjct: 311 MLNSDPKQRLTAAQVLNHPWIKEDGEAPDVPLDNAVMSRLKQFKAMN 357
>At4g26890 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 444
Score = 113 bits (283), Expect = 1e-24
Identities = 109/381 (28%), Positives = 178/381 (46%), Gaps = 44/381 (11%)
Query: 18 RKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITH 77
R IIGRG V A + +++A+K +L ++ ++KE LS+L +P++
Sbjct: 7 RGPIIGRGSTATVSIAIS-SSGELFAVKSADLSSSSL----LQKEQSILSTLS-SPHMVK 60
Query: 78 YYGSYLIDTKLW----VIMEYCAGGSLRTLLRP--GIIEEKYIGVIMREILVALISIHRD 131
Y G+ L ++MEY +GG+L L++ G + E I R+IL L+ +H
Sbjct: 61 YIGTGLTRESNGLVYNILMEYVSGGNLHDLIKNSGGKLPEPEIRSYTRQILNGLVYLHER 120
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYD 191
++H D+K+ N+L+ NG +K+ D G A + +S +GTP +MAPEV G
Sbjct: 121 GIVHCDLKSHNVLVEENGVLKIADMGCAKSVDKS-----EFSGTPAFMAPEV-ARGEEQR 174
Query: 192 TKVDIWSLGITAYEIATGNPPYCHM-EAIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
D+W+LG T E+ TG+ P+ + + + AM I S S K+F+ CL
Sbjct: 175 FPADVWALGCTMIEMMTGSSPWPELNDVVAAMYKIGFSGESPAIPAWISDKAKDFLKNCL 234
Query: 251 DEDPKERPYAEELFKSKLIKQEKGTSTV-ILKE--------LITRYLLFREKNEQY---- 297
ED K+R EEL K + ++ + T LK L R+ E ++ +
Sbjct: 235 KEDQKQRWTVEELLKHPFLDDDEESQTSDCLKNKTSSPSTVLDQRFWDSCESSKSHLVSI 294
Query: 298 KHEE--ESHTSSKQNPNSSIEGNASQDAGSFTEKEPED----IDIKWDFDSLSSREYILE 351
HE+ ++ S +P IE A + S + + ED I ++ + + + E
Sbjct: 295 DHEDPFAEYSESLDSPADRIEKLAGDEFSSLLDWDTEDDGGWIQVRGEKHKETEKRDGDE 354
Query: 352 NDINVEA------IPEEADWI 366
+ I VEA I E DWI
Sbjct: 355 DVICVEATSSSQTIEEVEDWI 375
>At4g14580 [T] KOG0583 Serine/threonine protein kinase
Length = 426
Score = 113 bits (283), Expect = 1e-24
Identities = 75/249 (30%), Positives = 125/249 (50%), Gaps = 23/249 (9%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIR--KEIQFLSSLKQTPNITHYY 79
+G G F V+ A + T ++ AIK+++ T D + R +EI+ + L PN+ +
Sbjct: 27 LGSGSFAKVHVARSISTGELVAIKIIDKQKTIDSGMEPRIIREIEAMRRLHNHPNVLKIH 86
Query: 80 GSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
+K+++++EY AGG L T L+R G + E +++ AL HRD + HRD+
Sbjct: 87 EVMATKSKIYLVVEYAAGGELFTKLIRFGRLNESAARRYFQQLASALSFCHRDGIAHRDV 146
Query: 139 KAANILIANNGSVKLCDFGVAA----QLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
K N+L+ G++K+ DFG++A + + +L T GTP + APEVI + Y K
Sbjct: 147 KPQNLLLDKQGNLKVSDFGLSALPEHRSNNGLL--HTACGTPAYTAPEVIAQRGYDGAKA 204
Query: 195 DIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREY------SQPLKEFIAL 248
D WS G+ + + G P+ + + I K R+Y S+P + I
Sbjct: 205 DAWSCGVFLFVLLAGYVPFDDANIVAMYRKIHK--------RDYRFPSWISKPARSIIYK 256
Query: 249 CLDEDPKER 257
LD +P+ R
Sbjct: 257 LLDPNPETR 265
>At3g57530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 560
Score = 113 bits (283), Expect = 1e-24
Identities = 77/271 (28%), Positives = 129/271 (47%), Gaps = 11/271 (4%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTPNITHYY 79
+GRG+FGV Y +T V+A K + T ++ED+R+E++ + + + PN+
Sbjct: 69 LGRGEFGVTYLCTDKETDDVFACKSILKKKLRTAVDIEDVRREVEIMRHMPEHPNVVTLK 128
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
+Y + + ++ME C GG L ++ G E+ + + I+ + H+ V+HRD+
Sbjct: 129 ETYEDEHAVHLVMELCEGGELFDRIVARGHYTERAAAAVTKTIMEVVQVCHKHGVMHRDL 188
Query: 139 KAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L N +K DFG++ + + G+PY+MAPEV+ Y +VD
Sbjct: 189 KPENFLFGNKKETAPLKAIDFGLSVFFKPGE-RFNEIVGSPYYMAPEVLKRN--YGPEVD 245
Query: 196 IWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPP--RLEGREYSQPLKEFIALCLDED 253
IWS G+ Y + G PP+ Q I +S R + S+ K+ I LD D
Sbjct: 246 IWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVLDFRRDPWPKVSENAKDLIRKMLDPD 305
Query: 254 PKERPYAEELFKSKLIKQEKGTSTVILKELI 284
K R A+++ ++ K V L E +
Sbjct: 306 QKRRLTAQQVLDHPWLQNAKTAPNVSLGETV 336
>At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 366
Score = 113 bits (283), Expect = 1e-24
Identities = 79/255 (30%), Positives = 131/255 (50%), Gaps = 12/255 (4%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
IG G G VYK H + ++YA+KV+ ++ E I +EI+ L + PN+ +
Sbjct: 85 IGSGAGGTVYKVIHRPSSRLYALKVIYGNHEETVRRQICREIEILRDVNH-PNVVKCHEM 143
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAA 141
+ + ++ V++E+ GSL + +E+ + + R+IL L +H +++HRDIK +
Sbjct: 144 FDQNGEIQVLLEFMDKGSLEGA---HVWKEQQLADLSRQILSGLAYLHSRHIVHRDIKPS 200
Query: 142 NILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI----MEGVYYDTKVDIW 197
N+LI + +VK+ DFGV+ L+Q+M + GT +M+PE I +G Y DIW
Sbjct: 201 NLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGKYDGYAGDIW 260
Query: 198 SLGITAYEIATGNPPY---CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDP 254
SLG++ E G P+ + M I S+PP S + FI+ CL +P
Sbjct: 261 SLGVSILEFYLGRFPFPVSRQGDWASLMCAICMSQPPEAPATA-SPEFRHFISCCLQREP 319
Query: 255 KERPYAEELFKSKLI 269
+R A +L + I
Sbjct: 320 GKRRSAMQLLQHPFI 334
>7299536 [D] KOG0580 Serine/threonine protein kinase
Length = 411
Score = 113 bits (283), Expect = 1e-24
Identities = 68/198 (34%), Positives = 115/198 (57%), Gaps = 9/198 (4%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVL-NLDNTEDEVE-DIRKEIQFLSSLKQTPNITHY 78
++GRGKFG VY A ++Q V A+KVL E VE +R+EI+ S L+ P+I
Sbjct: 159 LLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRH-PHILRL 217
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRPGII---EEKYIGVIMREILVALISIHRDNVIH 135
Y + D ++++I+EY G+L L+ + +E+ ++ + AL+ +H ++IH
Sbjct: 218 YAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIH 277
Query: 136 RDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
RDIK N+L+ + G +K+ DFG + SM R T+ GT ++ PE++ +G + VD
Sbjct: 278 RDIKPENLLLGHKGVLKIADFGWSVHEPNSM--RMTLCGTVDYLPPEMV-QGKPHTKNVD 334
Query: 196 IWSLGITAYEIATGNPPY 213
+WSLG+ +E+ G+ P+
Sbjct: 335 LWSLGVLCFELLVGHAPF 352
>CE28744 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 879
Score = 113 bits (282), Expect = 2e-24
Identities = 83/279 (29%), Positives = 142/279 (50%), Gaps = 32/279 (11%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQ------VYAIKVLN---LDNTEDEVEDIRKEIQFL 66
F+R +++G G +G K F V+ Q +YA+KV+ + TE ++ R E + L
Sbjct: 23 FERLKLVGEGGYG---KVFQVRKQTGEDKGTIYAMKVITKRKVTGTEKDLRHARDERKIL 79
Query: 67 SSLKQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLL-RPGIIEEKYIGVIMREILVAL 125
++ +P + + ++ + KL++++E+ GG L TLL R E+Y + EI++A+
Sbjct: 80 ETIN-SPFLCDLHYAFQTNEKLYLVLEFLHGGELYTLLERKSDWPEEYARFYLSEIILAI 138
Query: 126 ISIHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIM 185
+H ++++RD+K N+++ G V L DFG+ + K T GT +MAPE+I
Sbjct: 139 EHLHGHDIVYRDLKPDNVMLNLAGHVVLTDFGLCKYKLKKGEKTLTFCGTHEYMAPEMIR 198
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSK---PPRLEGREYSQPL 242
+ V +D VD+W+LGI Y++ G PP+ + I K K PP+L S
Sbjct: 199 K-VGHDHAVDVWALGILMYDMFMGGPPFTGETPADKDKSILKGKVRLPPKL-----SASG 252
Query: 243 KEFIALCLDEDP---------KERPYAEELFKSKLIKQE 272
K+ I + DP KE + EE+ KL+ +
Sbjct: 253 KDLIKRIIKRDPTLRITIPDIKEHEFFEEIDWDKLMAHD 291
>CE16527 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 359
Score = 113 bits (282), Expect = 2e-24
Identities = 81/249 (32%), Positives = 125/249 (49%), Gaps = 15/249 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G +G V+K H ++ ++ A+K + +N D+ +++ + S + PNI ++G+
Sbjct: 70 VGAGYYGTVHKMQHNESGRLIAVKKIRYNNICDQTRLLKEHDTHMKS-ENVPNIVKFFGA 128
Query: 82 YLIDTKLWVIMEYCAGGSLRTL------LRPGIIEEKYIGVIMREILVALISIHRD-NVI 134
+ W+ ME S+ L ++ + E IG I I+ AL + R N I
Sbjct: 129 CFSEGDCWICMELM-DISIDFLYKRVYSVKKSRLNENIIGHITVCIVDALDYLKRKLNRI 187
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKV 194
HRD+K +NILI G VKLCDFG+ L S AG ++APE I YD +
Sbjct: 188 HRDVKPSNILINAAGDVKLCDFGICGDLVGSYAIT-VEAGCVQYLAPERIENMDKYDIRS 246
Query: 195 DIWSLGITAYEIATGNPPY-CHMEAIRAMQMITKSKPP----RLEGREYSQPLKEFIALC 249
D+WSLGIT YEIATG PY + ++++ P + Y+ PL FI C
Sbjct: 247 DVWSLGITLYEIATGVYPYRGWSNQMEHIEIVVNGDSPILLQNMHNLHYTDPLCRFINTC 306
Query: 250 LDEDPKERP 258
L ++ +RP
Sbjct: 307 LRKNKDDRP 315
>CE08098 [T] KOG0612 Rho-associated coiled-coil containing protein kinase
Length = 1173
Score = 112 bits (281), Expect = 2e-24
Identities = 85/314 (27%), Positives = 150/314 (47%), Gaps = 30/314 (9%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNI 75
F++ ++IGRG FG V+ H +T VYA+K+LN D D+ K ++ +
Sbjct: 68 FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKD-------DMIKRADSAFFWEERDIM 120
Query: 76 THYYGSYLIDTK--------LWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALIS 127
H +++ + L+++MEY GG L L+ + EK+ EI+ AL +
Sbjct: 121 AHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYEVSEKWTRFYTAEIVEALAA 180
Query: 128 IHRDNVIHRDIKAANILIANNGSVKLCDFGVAAQL-SQSMLKRQTMAGTPYWMAPEVIM- 185
+H IHRD+K N+LI+ +G +KL DFG ++ + +++ T GTP +++PEV+
Sbjct: 181 LHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRN 240
Query: 186 --EGVYYDTKVDIWSLGITAYEIATGNPPYCHMEAI-----RAMQMITKSKPP--RLEGR 236
+ + +VD WS+G+ YE+ G P+ + EA+ M T K P L
Sbjct: 241 QGQDAEFGKEVDWWSVGVFIYEMLVGETPF-YAEALVSTYTNIMNHKTSLKFPDEPLIST 299
Query: 237 EYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQ 296
+ +K+F++ D R +++ K ++ T L+E + + ++
Sbjct: 300 QAKDIIKKFLSAA--PDRLGRNSVDDIRNHKFFVNDEWTFAT-LREASPPVIPSLKSDDD 356
Query: 297 YKHEEESHTSSKQN 310
H EE T + N
Sbjct: 357 TTHFEEIETRDRDN 370
>At1g61950 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 547
Score = 112 bits (281), Expect = 2e-24
Identities = 95/363 (26%), Positives = 170/363 (46%), Gaps = 37/363 (10%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVL---NLDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
+GRG+FG+ Y + + + +A K + L T+D ED+R+EIQ + L PNI
Sbjct: 104 LGRGQFGITYICTEISSGKNFACKSILKRKLIRTKDR-EDVRREIQIMHYLSGQPNIVEI 162
Query: 79 YGSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRD 137
G+Y + ++ME C GG L + + G EK I+R ++ + H VIHRD
Sbjct: 163 KGAYEDRQSVHLVMELCEGGELFDKITKRGHYSEKAAAEIIRSVVKVVQICHFMGVIHRD 222
Query: 138 IKAANILIAN----NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
+K N L+++ + +K DFGV+ + + + + + G+ Y++APEV+ Y
Sbjct: 223 LKPENFLLSSKDEASSMLKATDFGVSVFIEEGKV-YEDIVGSAYYVAPEVLKRN--YGKA 279
Query: 194 VDIWSLGITAYEIATGNPPYCH------MEAIRAMQMITKSKPPRLEGREYSQPLKEFIA 247
+DIWS G+ Y + GNPP+ E I ++ +S+P S+ K+ +
Sbjct: 280 IDIWSAGVILYILLCGNPPFWAETDKGIFEEILRGEIDFESEP----WPSISESAKDLVR 335
Query: 248 LCLDEDPKERPYAEELFKSKLIKQ-----EKGTSTVILKELITRYLLFREKNEQYKHEEE 302
L DPK+R A ++ + I++ +K + +L + + + K +K +
Sbjct: 336 NMLKYDPKKRFTAAQVLEHPWIREGGEASDKPIDSAVLSRMKQLRAMNKLKKLAFKFIAQ 395
Query: 303 SHTSSKQNPNSSIEGNASQD-AGSFTEKEPEDIDIKWDFDSLSSREYILENDINVEAIPE 361
+ + ++ N D +G+ T E +K + L SR + V+ + E
Sbjct: 396 NLKEEELKGLKTMFANMDTDKSGTITYDE-----LKSGLEKLGSR----LTETEVKQLLE 446
Query: 362 EAD 364
+AD
Sbjct: 447 DAD 449
>Hs4506067 [T] KOG0696 Serine/threonine protein kinase
Length = 672
Score = 112 bits (280), Expect = 3e-24
Identities = 62/196 (31%), Positives = 106/196 (53%), Gaps = 4/196 (2%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTPNITHY 78
++G+G FG V A T+++YAIK+L D +D+VE E + L+ L + P +T
Sbjct: 344 VLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQL 403
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNVIHRD 137
+ + +L+ +MEY GG L ++ G +E EI + L +H+ +I+RD
Sbjct: 404 HSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRD 463
Query: 138 IKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIW 197
+K N+++ + G +K+ DFG+ + + +T GTP ++APE+I Y VD W
Sbjct: 464 LKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQP-YGKSVDWW 522
Query: 198 SLGITAYEIATGNPPY 213
+ G+ YE+ G PP+
Sbjct: 523 AYGVLLYEMLAGQPPF 538
>CE28218 [D] KOG0588 Serine/threonine protein kinase
Length = 914
Score = 112 bits (280), Expect = 3e-24
Identities = 64/201 (31%), Positives = 112/201 (54%), Gaps = 6/201 (2%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEV-EDIRKEIQFLSSLKQTPN 74
+K ++ +G+G+ G+V H T + AIK++N + + V + + +EI + ++ P+
Sbjct: 47 YKLEKTLGKGQTGLVKTGTHCITGRKVAIKIVNKEKLSESVLQKVEREIAIMKLIEH-PH 105
Query: 75 ITHYYGSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISIHRDNV 133
+ H Y Y L++++E+ +GG L L+R G + K R+I+ AL H N+
Sbjct: 106 VLHLYDVYENKKYLYLLLEHVSGGELFDYLVRKGRLMSKEARKFFRQIISALDFCHAHNI 165
Query: 134 IHRDIKAANILIANNGSVKLCDFGVAA-QLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
HRD+K N+L+ ++K+ DFG+A+ Q+ SML +T G+P++ PEVI Y
Sbjct: 166 CHRDLKPENLLLDERNNIKVADFGMASLQVEGSML--ETSCGSPHYACPEVIRGEKYDGR 223
Query: 193 KVDIWSLGITAYEIATGNPPY 213
K D+WS G+ Y + G P+
Sbjct: 224 KADVWSCGVILYALLVGALPF 244
>CE27768 [R] KOG0586 Serine/threonine protein kinase
Length = 1096
Score = 112 bits (280), Expect = 3e-24
Identities = 75/257 (29%), Positives = 133/257 (51%), Gaps = 12/257 (4%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQT--P 73
+K + IG+G F V A HV T AIK++ D T ++K + + +KQ P
Sbjct: 122 YKLLKTIGKGNFAKVKLAKHVITGHEVAIKII--DKTALNPSSLQKLFREVKIMKQLDHP 179
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISIHRDN 132
NI Y + L++++EY +GG + L+ G ++EK R+I+ A+ +H N
Sbjct: 180 NIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKN 239
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
+IHRD+KA N+L+ + ++K+ DFG + S K T G+P + APE+ Y
Sbjct: 240 IIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGN-KLDTFCGSPPYAAPELFSGKKYDGP 298
Query: 193 KVDIWSLGITAYEIATGNPPY--CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
+VD+WSLG+ Y + +G+ P+ +++ +R + K + P + LK+F+ +
Sbjct: 299 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVI-- 356
Query: 251 DEDPKERPYAEELFKSK 267
+P+ R + + K +
Sbjct: 357 --NPQRRSSLDNIMKDR 371
>CE23838 [R] KOG0586 Serine/threonine protein kinase
Length = 1192
Score = 112 bits (280), Expect = 3e-24
Identities = 75/257 (29%), Positives = 133/257 (51%), Gaps = 12/257 (4%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQT--P 73
+K + IG+G F V A HV T AIK++ D T ++K + + +KQ P
Sbjct: 170 YKLLKTIGKGNFAKVKLAKHVITGHEVAIKII--DKTALNPSSLQKLFREVKIMKQLDHP 227
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISIHRDN 132
NI Y + L++++EY +GG + L+ G ++EK R+I+ A+ +H N
Sbjct: 228 NIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKN 287
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDT 192
+IHRD+KA N+L+ + ++K+ DFG + S K T G+P + APE+ Y
Sbjct: 288 IIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGN-KLDTFCGSPPYAAPELFSGKKYDGP 346
Query: 193 KVDIWSLGITAYEIATGNPPY--CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCL 250
+VD+WSLG+ Y + +G+ P+ +++ +R + K + P + LK+F+ +
Sbjct: 347 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVI-- 404
Query: 251 DEDPKERPYAEELFKSK 267
+P+ R + + K +
Sbjct: 405 --NPQRRSSLDNIMKDR 419
>At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 257
Score = 112 bits (280), Expect = 3e-24
Identities = 71/212 (33%), Positives = 112/212 (52%), Gaps = 8/212 (3%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEV-EDIRKEIQFLSSLKQTPNITHYYG 80
IG G F VV++A H AIK + +D ++ E + EI L + PNI
Sbjct: 18 IGSGSFSVVWEARHRVDGTEVAIKEIAMDRLNKKLQESLMSEIFILRRINH-PNIIRLID 76
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLL-RPGIIEEKYIGVIMREILVALISIHRDNVIHRDIK 139
K+ +++EYC GG L + R GI+ E M+++ L + +N+IHRD+K
Sbjct: 77 MIKSPGKVHLVLEYCKGGDLSVYVQRHGIVPEATAKHFMQQLAAGLQVLRDNNIIHRDLK 136
Query: 140 AANILIA---NNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDI 196
N+L++ N+ +K+ DFG A L L +T+ G+P +MAPE IM+ YD K D+
Sbjct: 137 PQNLLLSTNENDADLKIADFGFARSLQPRGL-AETLCGSPLYMAPE-IMQLQKYDAKADL 194
Query: 197 WSLGITAYEIATGNPPYCHMEAIRAMQMITKS 228
WS+G +++ TG P+ I+ +Q I +S
Sbjct: 195 WSVGAILFQLVTGRTPFTGNSQIQLLQNIIRS 226
>SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 340
Score = 112 bits (279), Expect = 4e-24
Identities = 80/251 (31%), Positives = 133/251 (52%), Gaps = 17/251 (6%)
Query: 22 IGRGKFGVVYKAFHVKTQQVY-AIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
+G G G V VK + ++ A K + + + + I +E+ L + +P I +YG
Sbjct: 72 LGEGNGGAVSL---VKHRNIFMARKTVYVGSDSKLQKQILRELGVLHHCR-SPYIVGFYG 127
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLLRPG-IIEEKYIGVIMREILVALISIHRD-NVIHRDI 138
++ + + MEY GSL +LR G I +G I+ ++ LI ++ ++IHRD+
Sbjct: 128 AFQYKNNISLCMEYMDCGSLDAILREGGPIPLDILGKIINSMVKGLIYLYNVLHIIHRDL 187
Query: 139 KAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWS 198
K +N+++ + G +KLCDFGV+ +L S+ QT GT +M+PE I G Y K DIWS
Sbjct: 188 KPSNVVVNSRGEIKLCDFGVSGELVNSV--AQTFVGTSTYMSPERI-RGGKYTVKSDIWS 244
Query: 199 LGITAYEIATGNPPYC------HMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDE 252
LGI+ E+AT P+ + + + I + +PPRL + + L+ F+ CL +
Sbjct: 245 LGISIIELATQELPWSFSNIDDSIGILDLLHCIVQEEPPRLPS-SFPEDLRLFVDACLHK 303
Query: 253 DPKERPYAEEL 263
DP R ++L
Sbjct: 304 DPTLRASPQQL 314
>Hs4885583 [T] KOG0612 Rho-associated coiled-coil containing protein kinase
Length = 1354
Score = 112 bits (279), Expect = 4e-24
Identities = 65/205 (31%), Positives = 114/205 (54%), Gaps = 17/205 (8%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRK-------EIQFLSSLKQT 72
++IGRG FG V H T++VYA+K+L+ + E I++ E + + + +
Sbjct: 80 KVIGRGAFGEVQLVRHKSTRKVYAMKLLS------KFEMIKRSDSAFFWEERDIMAFANS 133
Query: 73 PNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDN 132
P + + ++ D L+++MEY GG L L+ + EK+ E+++AL +IH
Sbjct: 134 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMG 193
Query: 133 VIHRDIKAANILIANNGSVKLCDFGVAAQLS-QSMLKRQTMAGTPYWMAPEVIME---GV 188
IHRD+K N+L+ +G +KL DFG +++ + M++ T GTP +++PEV+
Sbjct: 194 FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDG 253
Query: 189 YYDTKVDIWSLGITAYEIATGNPPY 213
YY + D WS+G+ YE+ G+ P+
Sbjct: 254 YYGRECDWWSVGVFLYEMLVGDTPF 278
>CE25437 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 387
Score = 112 bits (279), Expect = 4e-24
Identities = 80/280 (28%), Positives = 129/280 (45%), Gaps = 42/280 (15%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGS 81
+G G GVV K H KT + A K+++L+ + I KE+ L +P I +YG+
Sbjct: 79 LGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCN-SPFIVGFYGA 137
Query: 82 YLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRD-NVIHRDIK 139
++ + + + MEY G SL +L+ G + EK++G I ++ L + + ++HRD+K
Sbjct: 138 FVDNNDISICMEYMDGLSLDIVLKKVGRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVK 197
Query: 140 AANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSL 199
+N+L+ +NG +KLCDFGV+ L SM + GT +MAPE + G +Y DIWS
Sbjct: 198 PSNMLVNSNGEIKLCDFGVSGMLIDSM--ANSFVGTRSYMAPE-RLTGSHYTISSDIWSF 254
Query: 200 GITAYEIATGNPPY------------------------------------CHMEAIRAMQ 223
G++ E+ G P M +
Sbjct: 255 GLSLVELLIGRYPVPAPSQAEYATMFNVAENEIELADSLEEPNYHPPSNPASMAIFEMLD 314
Query: 224 MITKSKPPRLEGREYSQPLKEFIALCLDEDPKERPYAEEL 263
I PP L R ++ + F++ CL + P ER + L
Sbjct: 315 YIVNGPPPTLPKRFFTDEVIGFVSKCLRKLPSERATLKSL 354
>At2g30040 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 463
Score = 112 bits (279), Expect = 4e-24
Identities = 97/359 (27%), Positives = 165/359 (45%), Gaps = 21/359 (5%)
Query: 18 RKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT-EDEVEDIRKEIQFLSSLKQTPNIT 76
R +GRG FG V KA ++A+K ++L + E + EI L S+K PNI
Sbjct: 19 RGSCVGRGCFGTVSKALSKIDGGLFAVKSIDLATCLPSQAESLENEIVILRSMKSHPNIV 78
Query: 77 HYYGSYLIDTKLWVI----MEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDN 132
+ G + +EY G + GI+ E + + ++ AL +H +
Sbjct: 79 RFLGDDVSKEGTASFRNLHLEYSPEGDVAN---GGIVNETLLRRYVWCLVSALSHVHSNG 135
Query: 133 VIHRDIKAANILIANNG-SVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYD 191
++H D+K+ N+L+ N G SVKL DFG A + +S + + G+P WMAPEV+ Y
Sbjct: 136 IVHCDVKSKNVLVFNGGSSVKLADFGSAVEFEKSTI-HVSPRGSPLWMAPEVVRR-EYQG 193
Query: 192 TKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLD 251
+ D+WSLG T E+ TG P + ++ I S S+ ++F+ CL
Sbjct: 194 PESDVWSLGCTVIEMLTGKPAW-EDHGFDSLSRIGFSNDLPFIPVGLSELGRDFLEKCLK 252
Query: 252 EDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLL------FREKNEQYKHEEESHT 305
D +R ++L + + Q+ S E R +L F E+ E + ES
Sbjct: 253 RDRSQRWSCDQLLQHPFLCQDHHDS--FFTESSPRCVLDWVNSEFDEEEESDEWRPESMV 310
Query: 306 SSKQNPNS-SIEGNASQDAGSFTEKEPEDIDIKWDFDSLSSREYILENDINVEAIPEEA 363
S+ + +I G A+ ++ +TE + + + L S LE+ I++E+ +++
Sbjct: 311 SAMARISKLAITGGANWESNGWTEVRDTSEESEAKKEVLVSPRVELESYISLESSSDDS 369
>7294770 [T] KOG0603 Ribosomal protein S6 kinase
Length = 1207
Score = 112 bits (279), Expect = 4e-24
Identities = 87/331 (26%), Positives = 162/331 (48%), Gaps = 33/331 (9%)
Query: 16 FKRKEIIGRGKFGVVY---KAFHVKTQQVYAIKVLN---LDNTEDEVEDIRKEIQFLSSL 69
FK ++G G +G V+ K ++YA+KVLN + E + E L ++
Sbjct: 261 FKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAI 320
Query: 70 KQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISI 128
++ P + + ++ +KL++++++ GG L T L EE + V + E+++AL +
Sbjct: 321 QRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQL 380
Query: 129 HRDNVIHRDIKAANILIANNGSVKLCDFGVAAQL-SQSMLKRQTMAGTPYWMAPEVIMEG 187
H+ +I+RDIK NIL+ G + L DFG++ L +++ + + GT +MAPE+I G
Sbjct: 381 HQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTG 440
Query: 188 -VYYDTKVDIWSLGITAYEIATGNPPYC----HMEAIRAMQMITKSKPPRLEGREYSQPL 242
+D+ VD WS+G+ +E+ TG P+ ++ + I K +P + +S
Sbjct: 441 PPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQP--MIPSSFSANA 498
Query: 243 KEFIALCLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEE 302
++F+ L+++PK R S+ IK+ + + +EL T + + YK
Sbjct: 499 RDFVLKMLEKNPKRRLGGNHRDASE-IKEHPFFNGINWQELRT-----KRRKAPYK---- 548
Query: 303 SHTSSKQNPNSSIEGNASQDAGSFTEKEPED 333
P + E + + FT++ PED
Sbjct: 549 --------PTLTAEDDVQNFSNEFTDQVPED 571
Score = 85.9 bits (211), Expect = 3e-16
Identities = 74/328 (22%), Positives = 134/328 (40%), Gaps = 25/328 (7%)
Query: 25 GKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYGSYLI 84
G +G + T V+ K++ L D I NI Y+G++
Sbjct: 632 GAYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDAL--ISCALDTTNHKNIVSYHGTFRE 689
Query: 85 DTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDIKAANIL 144
+ W++MEY +G L +R ++E I ++++A+ IH + IH D+K NI+
Sbjct: 690 KCETWIVMEYLSGPELTASIR---MDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPENIM 746
Query: 145 IAN--NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEG--VYYDTKVDIWSLG 200
N + +VKL DFG A ++ + T + PE++ + V Y VDI+ LG
Sbjct: 747 FENREDRTVKLIDFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGLG 806
Query: 201 ITAYEIATGNPPY------------CHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIAL 248
T Y + G+ PY H E + M+ T ++ + S + ++
Sbjct: 807 ATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQ-RSMRWESASPAFRHLVSW 865
Query: 249 CLDEDPKERPYAEELFKSKLIKQEKGTSTVILKELITRYLLFREKNEQYKHEEESHTSSK 308
CL DP +RP ++ S+ ++ V ++I + + +E +
Sbjct: 866 CLQRDPADRPTLSDILDSEWLQYGSNDPDV---DIILPQQMVVDLSEDTMEQPTGGMFDD 922
Query: 309 QNPNSSIEGNASQDAGSFTEKEPEDIDI 336
Q + +++D G EP D +
Sbjct: 923 QQQLEFMHDKSAEDEGITLVSEPMDTTV 950
>Hs4885563 [T] KOG0694 Serine/threonine protein kinase
Length = 737
Score = 111 bits (278), Expect = 5e-24
Identities = 66/197 (33%), Positives = 106/197 (53%), Gaps = 4/197 (2%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTPNITH 77
+++G+G FG V A +VYA+KVL D +D+V+ E + L+ ++ P +T
Sbjct: 412 KVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQ 471
Query: 78 YYGSYLIDTKLWVIMEYCAGGSLR-TLLRPGIIEEKYIGVIMREILVALISIHRDNVIHR 136
Y + +L+ +MEY GG L + R +E E+ AL+ +H+ VI+R
Sbjct: 472 LYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYR 531
Query: 137 DIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDI 196
D+K NIL+ G KL DFG+ + + + T GTP ++APE++ E + Y VD
Sbjct: 532 DLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQE-LEYGPSVDW 590
Query: 197 WSLGITAYEIATGNPPY 213
W+LG+ YE+ G PP+
Sbjct: 591 WALGVLMYEMMAGQPPF 607
>At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 310
Score = 111 bits (278), Expect = 5e-24
Identities = 79/267 (29%), Positives = 136/267 (50%), Gaps = 16/267 (5%)
Query: 17 KRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNIT 76
++ ++G G G+VYK H T ++YA+K +N D + +E++ L +P +
Sbjct: 48 EKLNVLGCGNGGIVYKVRHKTTSEIYALKTVNGDMDPIFTRQLMREMEILRRT-DSPYVV 106
Query: 77 HYYGSYL--IDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRDNVI 134
+G + + ++ ++MEY GG+L +L R G+ E+K G ++IL L +H ++
Sbjct: 107 KCHGIFEKPVVGEVSILMEYMDGGTLESL-RGGVTEQKLAG-FAKQILKGLSYLHALKIV 164
Query: 135 HRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVI---MEGVYYD 191
HRDIK AN+L+ + VK+ DFGV+ L +S+ + GT +M+PE G D
Sbjct: 165 HRDIKPANLLLNSKNEVKIADFGVSKILVRSLDSCNSYVGTCAYMSPERFDSESSGGSSD 224
Query: 192 TKV-DIWSLGITAYEIATGN----PPYCHMEAIRAMQMITKSKPPRL-EGREYSQPLKEF 245
DIWS G+ E+ G+ PP + M + +PPR EG S+ + F
Sbjct: 225 IYAGDIWSFGLMMLELLVGHFPLLPPGQRPDWATLMCAVCFGEPPRAPEG--CSEEFRSF 282
Query: 246 IALCLDEDPKERPYAEELFKSKLIKQE 272
+ CL +D +R A +L ++++
Sbjct: 283 VECCLRKDSSKRWTAPQLLAHPFLRED 309
>Hs5453976 [T] KOG0694 Serine/threonine protein kinase
Length = 706
Score = 111 bits (277), Expect = 7e-24
Identities = 70/241 (29%), Positives = 118/241 (48%), Gaps = 6/241 (2%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVEDIRKEIQFLSSLKQTPNITH 77
+++G+G FG V+ A KT Q +AIK L D +D+VE E + LS + P +TH
Sbjct: 384 KMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTH 443
Query: 78 YYGSYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNVIHR 136
+ ++ L+ +MEY GG L ++ + EI++ L +H +++R
Sbjct: 444 MFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYR 503
Query: 137 DIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVDI 196
D+K NIL+ +G +K+ DFG+ + K T GTP ++APE+++ G Y+ VD
Sbjct: 504 DLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILL-GQKYNHSVDW 562
Query: 197 WSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLEGREYSQPLKEFIALCLDEDPKE 256
WS G+ YE+ G P+ + I P R + K+ + +P++
Sbjct: 563 WSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNP--FYPRWLEKEAKDLLVKLFVREPEK 620
Query: 257 R 257
R
Sbjct: 621 R 621
>CE18699 [T] KOG0694 Serine/threonine protein kinase
Length = 1018
Score = 111 bits (277), Expect = 7e-24
Identities = 65/202 (32%), Positives = 104/202 (51%), Gaps = 5/202 (2%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNT--EDEVED--IRKEIQFLSSLKQ 71
F+ ++GRG FG V + H T YA+KVL + DEVE + K I +SS +
Sbjct: 690 FRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDILGRDEVESLMVEKRIFEVSSRAR 749
Query: 72 TPNITHYYGSYLIDTKLWVIMEYCAGGSLRTLLRPGIIEEKYIGVIMREILVALISIHRD 131
P + + G + + ++ MEY GG L + + +E +++ L +H+
Sbjct: 750 HPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHDDVFDEVRGCFYAACVVLGLDFLHKH 809
Query: 132 NVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYD 191
N+I+RDIK N+L+ G VK+ DFG+ + K T GTP ++APEV+ + Y
Sbjct: 810 NIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPEFLAPEVLSDS-SYT 868
Query: 192 TKVDIWSLGITAYEIATGNPPY 213
+D W LG+ +E+ G PP+
Sbjct: 869 RAIDWWGLGVLIFEMLVGEPPF 890
>CE05507 [T] KOG0603 Ribosomal protein S6 kinase
Length = 785
Score = 111 bits (277), Expect = 7e-24
Identities = 74/208 (35%), Positives = 114/208 (54%), Gaps = 11/208 (5%)
Query: 16 FKRKEIIGRGKFGVVYKAFHVKTQQ---VYAIKVLNLDNT---EDEVEDIRKEIQFLSSL 69
F ++G+G +G V+ V + +YA+KVL + +E E Q L L
Sbjct: 17 FALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTKQKTLEHTMAERQVLERL 76
Query: 70 KQTPNITHYYGSYLIDTKLWVIMEYCAGGSLRT-LLRPGIIEEKYIGVIMREILVALISI 128
+ TP + + + ++ DTKL ++MEY GG L T L G + + ++ E++VA+ S+
Sbjct: 77 RGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGHFDLEAARFVIAELVVAIDSL 136
Query: 129 HRDNVIHRDIKAANILIANNGSVKLCDFGVAAQLSQSMLKR-QTMAGTPYWMAPEVI--M 185
H+ VI+RD+K NIL+ G VKL DFG++ L R + GT +M+PEVI
Sbjct: 137 HQRKVIYRDLKLENILLDEEGHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINRP 196
Query: 186 EGVYYDTKVDIWSLGITAYEIATGNPPY 213
EG Y D VD WSLG+ ++E+ TG P+
Sbjct: 197 EGGYSDV-VDWWSLGVISFELLTGCSPF 223
Score = 77.4 bits (189), Expect = 1e-13
Identities = 72/292 (24%), Positives = 122/292 (41%), Gaps = 39/292 (13%)
Query: 21 IIGRGKFGVVYKAFHVKTQQVYAIKVLNLDNTEDEVEDIRKEIQFLSSLKQTPNITHYYG 80
++G+G F VV + V +A+K+++ + ++E + L ++ PNI +
Sbjct: 387 LLGKGAFSVVRRCERVVDGAQFAVKIVS----QKFASQAQREARILEMVQGHPNIVQLHD 442
Query: 81 SYLIDTKLWVIMEYCAGGSLRTLLRP-GIIEEKYIGVIMREILVALISIHRDNVIHRDIK 139
+ +++ME G L +R E IMR+++ A+ +H ++HRD+K
Sbjct: 443 VHSDPLHFYLVMEILTGNELLERIRKLERFTESEAADIMRQLVSAVKYLHDKRIVHRDLK 502
Query: 140 AANIL---IANNGSVKLCDFGVAAQLSQSM----------------------LKRQTMAG 174
NIL I ++ ++L DFG A L SM L +T
Sbjct: 503 PENILFESIDSSARLRLVDFGFARLLPNSMEQQLKSVQVLRKMYGLIAHNHSLHSETPCF 562
Query: 175 TPYWMAPEVIMEG---VYYDTKVDIWSLGITAYEIATGNPPY----CHMEAIRAMQMITK 227
T + APEV+ G Y+ + D+WSLG+ + + +G P+ A MQ I +
Sbjct: 563 TLQYAAPEVLDVGDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQESATEIMQRICR 622
Query: 228 SKPPRL--EGREYSQPLKEFIALCLDEDPKERPYAEELFKSKLIKQEKGTST 277
++ S K I L DPK+R +EL +K T
Sbjct: 623 AEFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSMQELTAHMWLKSSASMDT 674
>At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 601
Score = 111 bits (277), Expect = 7e-24
Identities = 83/288 (28%), Positives = 139/288 (47%), Gaps = 30/288 (10%)
Query: 22 IGRGKFGVV----YKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTPNI 75
+GRG FG +K K QQV A+KV+ T +ED+R+E++ L +L N+
Sbjct: 154 VGRGHFGYTCAAKFKKGDNKGQQV-AVKVIPKAKMTTAIAIEDVRREVKILRALSGHNNL 212
Query: 76 THYYGSYLIDTKLWVIMEYCAGGSL--RTLLRPGIIEEKYIGVIMREILVALISIHRDNV 133
H+Y +Y ++++ME C GG L R L R G E+ +M +IL + H V
Sbjct: 213 PHFYDAYEDHDNVYIVMELCEGGELLDRILSRGGKYTEEDAKTVMIQILNVVAFCHLQGV 272
Query: 134 IHRDIKAANILIA---NNGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYY 190
+HRD+K N L + +K DFG++ + + + G+ Y++APEV+ Y
Sbjct: 273 VHRDLKPENFLFTSKEDTSQLKAIDFGLSDYVRPDE-RLNDIVGSAYYVAPEVLHRS--Y 329
Query: 191 DTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKP-------PRLEGREYSQPLK 243
T+ DIWS+G+ Y + G+ P+ + + K+ P P L S +
Sbjct: 330 STEADIWSVGVIVYILLCGSRPFWARTESGIFRAVLKADPSFDDPPWPLL-----SSEAR 384
Query: 244 EFIALCLDEDPKERPYAEELFKSKLIKQE---KGTSTVILKELITRYL 288
+F+ L++DP++R A + IK K +++ +L+ YL
Sbjct: 385 DFVKRLLNKDPRKRLTAAQALSHPWIKDSNDAKVPMDILVFKLMRAYL 432
>Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 878
Score = 110 bits (276), Expect = 9e-24
Identities = 70/206 (33%), Positives = 115/206 (54%), Gaps = 9/206 (4%)
Query: 20 EIIGRGKFGVVYKAFHVKTQQVYAIKVLN-LDNTEDEVEDIRKEIQFLSSLKQTPNITHY 78
E++G G+FGVVY H KT + A+KV++ L + +R E+ L SL+ P I +
Sbjct: 555 EVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRH-PGIVNL 613
Query: 79 YGSYLIDTKLWVIMEYCAGGSLRTLL--RPGIIEEKYIGVIMREILVALISIHRDNVIHR 136
+ K++V+ME G L +L G + E+ ++ +ILVAL +H N++H
Sbjct: 614 ECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHC 673
Query: 137 DIKAANILIANNG---SVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTK 193
D+K N+L+A+ VKLCDFG A + + +R ++ GTP ++APEV++ Y+
Sbjct: 674 DLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRR-SVVGTPAYLAPEVLL-NQGYNRS 731
Query: 194 VDIWSLGITAYEIATGNPPYCHMEAI 219
+D+WS+G+ Y +G P+ E I
Sbjct: 732 LDMWSVGVIMYVSLSGTFPFNEDEDI 757
>At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 599
Score = 110 bits (276), Expect = 9e-24
Identities = 75/256 (29%), Positives = 129/256 (50%), Gaps = 17/256 (6%)
Query: 20 EIIGRGKFGVV----YKAFHVKTQQVYAIKVLNLDNTED--EVEDIRKEIQFLSSLKQTP 73
E IGRG FG +K +K Q+V A+KV+ +ED+R+E++ L +L
Sbjct: 148 EEIGRGHFGYTCSAKFKKGELKDQEV-AVKVIPKSKMTSAISIEDVRREVKILRALSGHQ 206
Query: 74 NITHYYGSYLIDTKLWVIMEYCAGGSL--RTLLRPGIIEEKYIGVIMREILVALISIHRD 131
N+ +Y ++ + ++++ME C GG L R L R G E ++ +IL + H
Sbjct: 207 NLVQFYDAFEDNANVYIVMELCGGGELLDRILARGGKYSEDDAKAVLIQILNVVAFCHLQ 266
Query: 132 NVIHRDIKAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGV 188
V+HRD+K N L + N +K+ DFG+ + + + + G+ Y++APEV+
Sbjct: 267 GVVHRDLKPENFLYTSKEENSMLKVIDFGL-SDFVRPDERLNDIVGSAYYVAPEVLHRS- 324
Query: 189 YYDTKVDIWSLGITAYEIATGNPPYCHMEAIRAMQMITKSKPPRLE--GREYSQPLKEFI 246
Y T+ D+WS+G+ AY + G+ P+ + + K+ P E S K+F+
Sbjct: 325 -YTTEADVWSIGVIAYILLCGSRPFWARTESGIFRAVLKADPSFDEPPWPSLSFEAKDFV 383
Query: 247 ALCLDEDPKERPYAEE 262
L +DP++R A +
Sbjct: 384 KRLLYKDPRKRMTASQ 399
>At1g74740 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 567
Score = 110 bits (276), Expect = 9e-24
Identities = 64/198 (32%), Positives = 108/198 (54%), Gaps = 9/198 (4%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIKVLNLDN--TEDEVEDIRKEIQFLSSLKQTPNITHYY 79
+GRG+FG+ Y +T++ A K ++ T +VED+R+E+ +S+L + PN+
Sbjct: 65 LGRGEFGITYLCTDRETREALACKSISKRKLRTAVDVEDVRREVTIMSTLPEHPNVVKLK 124
Query: 80 GSYLIDTKLWVIMEYCAGGSL-RTLLRPGIIEEKYIGVIMREILVALISIHRDNVIHRDI 138
+Y + + ++ME C GG L ++ G E+ + R I + H + V+HRD+
Sbjct: 125 ATYEDNENVHLVMELCEGGELFDRIVARGHYTERAAATVARTIAEVVRMCHVNGVMHRDL 184
Query: 139 KAANILIAN---NGSVKLCDFGVAAQLSQSMLKRQTMAGTPYWMAPEVIMEGVYYDTKVD 195
K N L AN N ++K DFG++ L + + + G+PY+MAPEV+ Y +VD
Sbjct: 185 KPENFLFANKKENSALKAIDFGLSV-LFKPGERFTEIVGSPYYMAPEVLKRN--YGPEVD 241
Query: 196 IWSLGITAYEIATGNPPY 213
+WS G+ Y + G PP+
Sbjct: 242 VWSAGVILYILLCGVPPF 259
>Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 291
Score = 110 bits (276), Expect = 9e-24
Identities = 82/266 (30%), Positives = 136/266 (50%), Gaps = 20/266 (7%)
Query: 22 IGRGKFGVVYKAFHVKTQQVYAIK----VLNLDNTEDEV-EDIRKEIQFLSSLKQTPNIT 76
IG G F Y+A V T + A+K V N + ++EV E +R+EI+ +S L PNI
Sbjct: 26 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNH-PNII 84
Query: 77 HYYGSYLIDTKLWVIMEYCAGGSLRTLL-RPGIIEEKYIGVIMREILVALISIHRDNVIH 135
G+ + + +E+ AGGS+ LL + G +E + ++L L +H + +IH
Sbjct: 85 RMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIH 144
Query: 136 RDIKAANILIANNGS-VKLCDFGVAAQLSQSMLK----RQTMAGTPYWMAPEVIMEGVYY 190
RD+K AN+LI + G +++ DFG AA+L+ + + GT +MAPEV + G Y
Sbjct: 145 RDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEV-LRGQQY 203
Query: 191 DTKVDIWSLGITAYEIATGNPPY------CHMEAIRAMQMITKSKPPRLEGREYSQPLKE 244
D+WS+G E+A PP+ H+ I + + + + P + S L++
Sbjct: 204 GRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKVIIASATTAPSIPS-HLSPGLRD 262
Query: 245 FIALCLDEDPKERPYAEELFKSKLIK 270
CL+ P++RP + EL K + +
Sbjct: 263 VALRCLELQPQDRPPSRELLKHPVFR 288
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.311 0.129 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,172,900
Number of Sequences: 60738
Number of extensions: 2405046
Number of successful extensions: 12819
Number of sequences better than 1.0e-05: 1726
Number of HSP's better than 0.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 1411
Number of HSP's that attempted gapping in prelim test: 8210
Number of HSP's gapped (non-prelim): 2229
length of query: 1016
length of database: 30,389,216
effective HSP length: 116
effective length of query: 900
effective length of database: 23,343,608
effective search space: 21009247200
effective search space used: 21009247200
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)