ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV5898 good R KOG1064 General function prediction only RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV5898 2023109 2027197 1363
(1363 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJR033c [R] KOG1064 RAVE (regulator of V-ATPase assembly) comple... 1311 0.0
SPBC1105.10 [R] KOG1064 RAVE (regulator of V-ATPase assembly) co... 348 3e-95
7290688 [R] KOG1064 RAVE (regulator of V-ATPase assembly) comple... 144 1e-33
HsM9961349 [R] KOG1064 RAVE (regulator of V-ATPase assembly) com... 141 8e-33
Hs21536474 [R] KOG1064 RAVE (regulator of V-ATPase assembly) com... 141 8e-33
Hs19745148 [R] KOG1064 RAVE (regulator of V-ATPase assembly) com... 133 2e-30
At2g46560 [R] KOG1064 RAVE (regulator of V-ATPase assembly) comp... 124 1e-27
CE11074 [R] KOG1064 RAVE (regulator of V-ATPase assembly) comple... 119 4e-26
>YJR033c [R] KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit
RAV1/DMX protein WD repeat superfamily
Length = 1357
Score = 1311 bits (3393), Expect = 0.0
Identities = 676/1391 (48%), Positives = 938/1391 (66%), Gaps = 62/1391 (4%)
Query: 1 MTLSFLPGVPNSTPQAACQRSWNHNTILAYCSGNNLILLSNRSERLQTIYLNSDCHAVDV 60
M+L+FLPG PN+TPQ ACQ +W ++TI AYCSGNNLI+L+N+ RLQTIY SDC AVD+
Sbjct: 1 MSLNFLPGRPNATPQTACQATWQNHTIFAYCSGNNLIILTNKFTRLQTIYTQSDCTAVDI 60
Query: 61 NPRNGLIAVAVSQEVYIYKPLHQIMKNPKWVFCCKVYHDDSRVNTLQWGMGNELVLGSDY 120
N +NG IA++ V IYKP+HQIM+NPKW CC+++HDD+ VN L+W NEL +GSD+
Sbjct: 61 NSQNGFIALSFHNRVLIYKPIHQIMQNPKWTQCCQLFHDDTPVNCLRWSSDNELAIGSDF 120
Query: 121 LSFWDVKDVFGEYKPRLLWSKRQPLPVYLCSITSDSKLISSMNYNDRTVKIWRRVSITSD 180
LSFW +KD FG Y+P L W+++QP PVY I+ DS+LI S+ D K+W+RVSI +
Sbjct: 121 LSFWKIKDNFGVYQPILQWNQKQPKPVYNVIISQDSQLIVSIGKYDCNAKLWKRVSIVGE 180
Query: 181 SDFFDLVILPHPDVVTTFRWKTNDHQCNKEHI-THVIYTLCADRKLRVWISFDIDNKKNV 239
F+L +LPHP +T RWK Q +K + +H +YTLC D+ LR+W F+++ V
Sbjct: 181 QAIFNLTMLPHPKPITAMRWKKEPDQVSKNNTASHALYTLCEDKVLRIWSCFEMEKNHTV 240
Query: 240 QQWGTVEMSKSNNERFCVILDSWLIQKTLRKTIKDQSHQSEMIKYILEKKPEIILFTTPS 299
Q WG V +S + ++FCVI+D+W+I++TL ++KD SE+ +I++ + +
Sbjct: 241 QIWGEVPLSPT--QKFCVIIDNWIIRQTL--SVKD----SEIFDI---SDSDIVILGSMT 289
Query: 300 LKIRVLALTNLSDDVPKIMSVKDLLRTSISNTAMGSSPEFVHFPEPQIFDDDKS-ISFVV 358
++ VLAL NLS D PK M+ K + + M + +++ PE Q +D+ K +SF+V
Sbjct: 290 GEMEVLALNNLSQDPPKPMTKKTISHKKVKKATMLNDTRYLYLPEIQPYDNVKGKLSFLV 349
Query: 359 HDLHGSVRHSLLHISSILNG-TETIGI-LQHKWTGHTKSIQKVFRSSYGSAILTTSRFQE 416
HDL G +RH L+ I ++N TE + L+HK+TGH KS+QK+ RSS G A+LTTSRF E
Sbjct: 350 HDLQGVIRHLLIDILQLINNKTEDLSAALEHKFTGHNKSVQKLVRSSDGEALLTTSRFSE 409
Query: 417 NSIWVPLRLKDSVTLSKKAMLISESPIKHALVHDRGNLVVTFLENCKVQLWVCSSN---- 472
N +W P +L V+L + + +ESPIK A+VH+ G V+ LEN +Q W C +N
Sbjct: 410 NGVWYPQKLNHGVSLRLQNTIQTESPIKFAVVHELGKQVICLLENGALQAWECPTNRKED 469
Query: 473 --EKRAILKSTFSADKTKGI-PSIMVNTSGNKPHNDQHFFAYVYPDGSSQGF-VFTKDDM 528
+K++ L+ + K I P +M+NT K +++HF A ++ DGS + F V +
Sbjct: 470 SEQKQSYLRVETRLKEEKKIHPIVMLNTPEPKHSHERHFTALIFSDGSIKAFEVSLTRGI 529
Query: 529 KQIDSNSIDLEGEEEFYLVSAIDPVRYQFQSDRSLIASITKLGVIRIYKAQADQSG--IR 586
++ S+S+D++G++ Y +S IDPV F S+R LI+ ITK G+ R YKA + + ++
Sbjct: 530 FEVKSDSLDIDGDD-IYKISIIDPVHQTFVSNRPLISLITKKGLTRTYKAIVNYNDRHVQ 588
Query: 587 WKKSYETITNITNASKITGSSNDKISVIDEKGTTMTLWDLRRSVLEYETTFDDEVVDIDW 646
W K+ E T I N + I GSS K+ +++ G M+LWDL R VLEYE TF + + DIDW
Sbjct: 589 WIKACEINTGIMNCTCIRGSSTGKLCIVNSTGKVMSLWDLNRGVLEYEETFHNPIEDIDW 648
Query: 647 TSTEFEQSIVAIGFENYVILYTQLRYDYTNRNPAYLPIEKINVSQHTTHAIGDSTWLKNG 706
TSTE+ QSIV+IGF Y +LYTQLRYDYTN P+YLPIEKI+++ HT H IGDS W+KNG
Sbjct: 649 TSTEYGQSIVSIGFTGYALLYTQLRYDYTNNTPSYLPIEKIDITAHTAHNIGDSVWMKNG 708
Query: 707 SIIIATGNQVFIKDKSLDLKDKFTYSSIGSRKILSNDILHLTSVLNGPLPIYHPQLLIQS 766
+ ++A+GNQ +IKDKSLDL D FTY SIGSRKILSNDILHL+SVLNGPLP+YHPQ LIQ+
Sbjct: 709 TFVVASGNQFYIKDKSLDLTDPFTYQSIGSRKILSNDILHLSSVLNGPLPVYHPQFLIQA 768
Query: 767 LFAKKVNLVREILLKLFHALRKMEFNSDEIHDIGSSLKLSPSKFLHTNDSTYVFDNYEEP 826
++A K+ LV+E+LL+LF ALRK++F S ++ ++ S+L + P K+ D Y +++ +P
Sbjct: 769 IYANKLQLVKELLLRLFLALRKLDFESQDVSNLDSNLGMDPLKYFIAKDRDYPVESFPDP 828
Query: 827 YSTFDSTVSAPLIDLLSKTPLPYLTRHQQVTLISVIEAVQEINLNEKVVDINGVRFMLGV 886
Y F+ TVS L + L+KT LPYLTRHQQ+TLI+VIEAV E+ NE +VD NGVRF+LGV
Sbjct: 829 YPCFNKTVSLALTEQLTKTTLPYLTRHQQITLITVIEAVDEVTKNENIVDYNGVRFLLGV 888
Query: 887 KLYTSHKSTQTSVNMRDVSWATHSDNKEILFSNLFNRLKKWDNVKEFKVPYWAGQQDLVK 946
KL+ SHK+ Q S+ MRDVSWA HSDNKEIL S++ + W+ +E+++ YW +QDLVK
Sbjct: 889 KLFLSHKNIQKSILMRDVSWALHSDNKEILLSSIDRHITSWNRAREYRIAYWIKEQDLVK 948
Query: 947 CFENIAKFEFNNYDKRDPSRCSIFYLALKKKSILIGLWRISSGHPEQAKMLKFLNNDFAE 1006
FE+IAK+EF+ DKRDPSRC+IFYLALKKK IL+ LW+++ GHPEQ KM++F++NDF
Sbjct: 949 KFEDIAKYEFSKDDKRDPSRCAIFYLALKKKQILLSLWKMAIGHPEQQKMVRFISNDFTV 1008
Query: 1007 PRWRSAALKNAFVLLSKHRYMDAATFFLLAGSLKDSINVLRKQLNDLDLAIGVCRVYEGD 1066
PRWR+AALKNAFVLLSKHRYMDAA FFLL SLKD +NVL KQ++D+DLAIGVCRVYEGD
Sbjct: 1009 PRWRTAALKNAFVLLSKHRYMDAAVFFLLTDSLKDCVNVLCKQVHDMDLAIGVCRVYEGD 1068
Query: 1067 NGPILHEFLHNQILPTAIIDSDRWTTSYVYWKMRKQDLAIKALVQPPVEVDDNYKWIEKD 1126
NGP+L E L Q+LP I ++DRW S++YWK+RKQ++AIKAL+ P+++++N ++K+
Sbjct: 1069 NGPVLGELLTAQMLPETIKENDRWKASFIYWKLRKQEVAIKALLTAPIDLENNSSIVDKE 1128
Query: 1127 KCVNKSFLVEDPXXXXXXXXXRDRNIDYYNAALEVNESLEYEIIMRVATIYTRMGCDYIA 1186
CVN+SFLVEDP R+RN+ Y+ +L V +E +I+RV I RMGC+Y+A
Sbjct: 1129 VCVNRSFLVEDPALLYLYNHLRNRNLKYFIGSLNVEAKIECTLILRVTDILCRMGCNYLA 1188
Query: 1187 VSLLKDWKFLESKKIESEQ-VEIPQSSHS-KLTDNKIEEPVTTQKVRPSLFDKFDSQFXX 1244
VSL+K+WKF+E I ++ ++ P + EP++T ++RPSLFDKF S
Sbjct: 1189 VSLVKNWKFIERNSIPVQKLLKSPTKDRAYSAIGAMASEPISTARMRPSLFDKFGSPSAS 1248
Query: 1245 XXXX--XXXXXXXXXXILNPTSRDINSSNGHSGKSAGSSFNILD-----SYRSDTQKVTP 1297
L P SSN + S+ + +ILD SY + +TP
Sbjct: 1249 DIESPNPKLPNSLLDDFLQPPPNS-TSSNSLAQSSSSAPRSILDEFVSPSYSQHKENLTP 1307
Query: 1298 SQVPNMLDSF-----KENQKDTIQKKLPTQQKSPLDDYQASTNKPFVPQQHLQNSKPKKT 1352
+ PN DS EN+KD + K + LDD S+ KP KPKK+
Sbjct: 1308 -KAPN--DSVGETDNSENRKDKLSKDI-------LDD--LSSQKP---------QKPKKS 1346
Query: 1353 AKPRSLLDDFI 1363
A ++LLDDF+
Sbjct: 1347 AITKNLLDDFV 1357
>SPBC1105.10 [R] KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit
RAV1/DMX protein WD repeat superfamily
Length = 1297
Score = 348 bits (894), Expect = 3e-95
Identities = 227/731 (31%), Positives = 383/731 (52%), Gaps = 68/731 (9%)
Query: 560 DRSLIASITKLGVIRIYKAQA---DQSGIRWKKSYETITNITNASKITGSSNDKISVIDE 616
D+ + SI+K G+++ + A+ D++ I + + T+I +A+ I GS++ K++V+ E
Sbjct: 563 DQEVFQSISKDGLLQTWMARVLGDDKAEI--SEISKVQTSIKSATMIKGSTSKKVAVVSE 620
Query: 617 KGTTMTLWDLRRSVL----EYETTFDD--EVVDIDWTSTEFEQSIVAIGFENYVILYTQL 670
++++D R S E+ + FDD + D+DWTST SI+A+GF + VIL Q
Sbjct: 621 NNRRLSIFDTRSSEFSEKEEFSSVFDDYGPINDLDWTSTPNSHSILAVGFLHDVILLCQN 680
Query: 671 RYDYTNRNPAYLPIEKINVSQHTTHAIGDSTWLKNGSIIIATGNQVFIKDKSLDLKDKFT 730
R Y N P + I + N+ ++T I DS+WL NG+++ A GN +F D SL
Sbjct: 681 RRSYMNDIPCWSRIRRYNLLEYTNSLISDSSWLDNGTLVTAIGNGLFYFDNSLPEDQSLL 740
Query: 731 YSSIGSRKILSNDILHLTSVLNGPLPIYHPQLLIQSLFAKKVNLVREILLKLF------- 783
+ + S K + +I L LNG LP++HPQLL Q L + L ILL+ +
Sbjct: 741 FPA--SLKRSAKNIFDLAYQLNGILPVFHPQLLQQLLLRNQPFLFTNILLRFYLCLKDDV 798
Query: 784 --HALRKMEFNS-----DEIHD--IGSSLKLSPSKFLHTNDSTYVFDNYEEPYSTFDSTV 834
H L M+ + +EI + SL + ++ L+ + + + + + +
Sbjct: 799 DMHFLLNMDCSEFYCCDEEISKDLLIKSLSQNSAEILNPAELDFEETSVSKHLGLYIDEM 858
Query: 835 SAPLIDLLSKTPLPYLTRHQQVTLISVIEAVQEINLNEKVVDINGVRF--MLGVKLYTSH 892
L LL + LTR Q L+++IEA + +D+NG R+ ML + + H
Sbjct: 859 IKKLTALLKVKKVKTLTRSSQFLLLNLIEAFNKARALRDSLDLNGKRYCIMLNQYVLSKH 918
Query: 893 KSTQTSVNMRDVSWATHSDNKEILFSN---LFNRLKKWDNVKEFKVPYWAGQQDLVKCFE 949
+ TS+ R+++WA HS NK +L + L + W+ V+E+ +P+W +Q L F
Sbjct: 919 QRQLTSLPTREMAWAFHSSNKAVLLDHTKKLHGKPLLWNAVEEYAIPFWLNEQLLKDVFL 978
Query: 950 NIAKFEFNNYDKRDPSRCSIFYLALKKKSILIGLWRISSGHPEQAKMLKFLNNDFAEPRW 1009
+++ + D R+P S++++AL K ++ LWR++S H E A+ +K L+NDF++ +W
Sbjct: 979 ELSRNHYAEIDDRNPENVSLYHIALHKINVFRDLWRLASWHKESARTVKLLSNDFSKKKW 1038
Query: 1010 RSAALKNAFVLLSKHRYMDAATFFLLAGSLKDSINVLRKQLNDLDLAIGVCRVYEGDNGP 1069
+ A KNAF LLSKHRY A+ FFLLA S D+ V + L + LAI + RVYEGD+GP
Sbjct: 1039 KVVASKNAFALLSKHRYFYASAFFLLADSCYDAAKVCIRNLKSISLAIAMTRVYEGDDGP 1098
Query: 1070 ILHEFLHNQILPTAIIDSDRWTTSYVYWKMRKQDLAIKALVQPPVEV------------D 1117
L ++ +LP A+ +DRW T++ + ++++ A+++LV P + D
Sbjct: 1099 TLKRLINEYVLPLAVSQNDRWLTNWSFTILKQEKKALQSLVSPIRSLVSDNDFIQLYTSD 1158
Query: 1118 DNYKWIEKDK---------CVNKSFLVEDPXXXXXXXXXRDRNIDYYNAALEVNESLEYE 1168
N + I ++K V F +DP R N+ +++ESLEY
Sbjct: 1159 KNDQEIHENKDSQRNSTNEPVRNKFPSDDPAFILLYECLRSSNV-------QIDESLEYR 1211
Query: 1169 IIMRVATIYTRMGCDYIAVSLLKDWKFLESK-----KIESEQVEIPQSSHSKLTDN-KIE 1222
++ A +Y ++GCD IA+ LL++WKF ++ + E V QS+ K D+ K+
Sbjct: 1212 FVLHNANVYCQLGCDLIALGLLRNWKFQKNPATAHLETEDYMVTDKQSAVEKTHDSPKLG 1271
Query: 1223 EPVTTQKVRPS 1233
+ + Q +RP+
Sbjct: 1272 KTLMGQDIRPT 1282
Score = 88.2 bits (217), Expect = 8e-17
Identities = 70/235 (29%), Positives = 110/235 (46%), Gaps = 18/235 (7%)
Query: 1 MTLSFL-PGVPNSTPQAACQRSWNHNTILAYCSGNNLILLSNRSERLQTIYLNSDCHAVD 59
M L+F PG P A WN N IL + + ++++ N E Q I AV
Sbjct: 1 MPLAFTNPGTPLKRTAAYDNVQWNQNRILTFGTRYTVLIIVNNYESYQNIQFGESIGAVA 60
Query: 60 VNPRNGLIAVAVSQEVYIYKPLHQIMKNPKWVFCCKVYHDDSRVNTLQWGMGNELVL-GS 118
++ R G +A+A Q + IYKP + + + ++ D + L WG +L+L S
Sbjct: 61 LDQRTGFLAIAHGQVLDIYKPADSLKWTHHYNYITQLSED---ITQLSWGYNFDLLLCAS 117
Query: 119 DYLSFWDVKDVFGEYKPRLLWSKRQPLPVYLCS-ITSDSKLISSMNYNDRTVKIWRRVS- 176
Y + F E KPRL+WS+ + +L S I+SD+ I+S+ + K+W+R S
Sbjct: 118 SYTKLIN----FSEDKPRLVWSQNRISDSFLSSTISSDACFIASIETKNPLAKVWQRTSP 173
Query: 177 ---ITSDSDFFDLVILPHPDVVTTFRWKTNDHQCNKEHITHVIYTLCADRKLRVW 228
++S DF LV HP V +W + H + T + T+ D LR+W
Sbjct: 174 QGTVSSCDDFSYLV---HPCRVRFSQWSKHLHP-DASGSTPFLSTVGYDNVLRIW 224
>7290688 [R] KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit
RAV1/DMX protein WD repeat superfamily
Length = 3429
Score = 144 bits (362), Expect = 1e-33
Identities = 94/271 (34%), Positives = 142/271 (51%), Gaps = 30/271 (11%)
Query: 864 AVQEINLNEKVVDINGVRFMLGVKLYT----------SHKSTQTSVNMRDVSWATHSDNK 913
AV++ + + +D G+RF+L +K +T + + V ++ WA HS+++
Sbjct: 1870 AVKDGSTSTDSLDDCGLRFLLAMKHFTYLLRCLPLQQRAQFQRQGVGTSNIVWAFHSESE 1929
Query: 914 EILFSNLFNRLK---KWDNVKEFKVPYWAGQ-QDLVKCFENIAKFEFNNYDKRDPSRCSI 969
E L + + + K +W +++ V YW L +C E +AK + K++P +I
Sbjct: 1930 EELLNLIPSYTKGDLRWATLRDLGVGYWLKNINTLRRCVEKLAKCAYQQ--KQEPLDAAI 1987
Query: 970 FYLALKKKSILIGLWRISSGHPEQAKMLKFLNNDFAEPRWRSAALKNAFVLLSKHRYMDA 1029
+YLA+KKKS++ GL+R KM F N+FAE RWR AALKNAFVLL K R+ A
Sbjct: 1988 YYLAMKKKSLVWGLFRSR----RDEKMTAFFGNNFAEDRWRKAALKNAFVLLGKQRFEHA 2043
Query: 1030 ATFFLLAGSLKDSINVLRKQLNDLDLAIGVCRVYEGD-NGPILHEFLHNQILPT------ 1082
FFLLA SL D+I V +L D LA+ + R+YEGD G H LH IL T
Sbjct: 2044 VAFFLLANSLNDAIEVCMNKLEDFQLALIIARLYEGDGEGCYYHHLLHEHILGTDAATGR 2103
Query: 1083 ---AIIDSDRWTTSYVYWKMRKQDLAIKALV 1110
+ D + S YW ++K ++ L+
Sbjct: 2104 CDLSRAHPDPFLRSMTYWTIKKYQESLNTLL 2134
>HsM9961349 [R] KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit
RAV1/DMX protein WD repeat superfamily
Length = 3027
Score = 141 bits (355), Expect = 8e-33
Identities = 98/319 (30%), Positives = 165/319 (51%), Gaps = 52/319 (16%)
Query: 842 LSKTPLPYLTRHQQVTLISVIEAV----------QEINLNEKVVDINGVRFMLGVKLYTS 891
L + LP L+R +Q++L+++ + + ++ + + +D G++F+L V+L+T
Sbjct: 1493 LLHSSLPGLSRMEQMSLMALADTIATTSTDIGESRDRSQGGETLDECGLKFLLAVRLHTF 1552
Query: 892 -------------HKSTQTSVNMRDVSWATHSDNKEILFSNLFNRLKK----WDNVKEFK 934
H+ TS +WA HS +E L N+ ++K W ++
Sbjct: 1553 LTTSLPAYRAQLLHQGLSTS----HFAWAFHSVAEEELL-NMLPAMQKDDPTWSELRAMG 1607
Query: 935 VPYWAGQQDLV-KCFENIAKFEFNNYDKRDPSRCSIFYLALKKKSILIGLWRISSGHPEQ 993
V +W ++ KC E +AK F Y K DP +IFYLA+KKK+++ GL+R +
Sbjct: 1608 VGWWVRNTRILRKCIEKVAKAAF--YRKNDPLDAAIFYLAMKKKAVIWGLYRAE----KN 1661
Query: 994 AKMLKFLNNDFAEPRWRSAALKNAFVLLSKHRYMDAATFFLLAGSLKDSINVLRKQLNDL 1053
+M +F ++F + RWR AALKNAF LL K R+ +A FFLLAG L+D+I V ++LND+
Sbjct: 1662 TRMTQFFGHNFEDERWRKAALKNAFSLLGKQRFEHSAAFFLLAGCLRDAIEVCLEKLNDI 1721
Query: 1054 DLAIGVCRVYEG--DNGPILHEFLHNQIL----PTAIIDS-------DRWTTSYVYWKMR 1100
LA+ + R+YE D L ++L P + + S D + S YW +
Sbjct: 1722 QLALVIARLYESEFDTSAAYKSILRKKVLGIDSPVSELCSLNINMHHDPFLRSMAYWILE 1781
Query: 1101 KQDLAIKALVQPPVEVDDN 1119
A++ L++ P+ +D+
Sbjct: 1782 DYSGALETLIKQPIRENDD 1800
Score = 69.7 bits (169), Expect = 3e-11
Identities = 58/251 (23%), Positives = 103/251 (40%), Gaps = 50/251 (19%)
Query: 29 AYCSGNNLILLSNRSERLQTI----YLNSDCHAVDVNPRNGLIAVAVSQEVYIYKPLHQI 84
AY SG ++++L + ERLQ I + N VD + + G IA + + I++P++
Sbjct: 30 AYASGCDIVILGSDFERLQIIPGAKHGNIQVGCVDCSMQQGKIAASYGNVISIFEPVNL- 88
Query: 85 MKNPKWVFCCKVYHD---------DSRVNTLQWG-MGNELVLGSDYLSFWDVKDV----- 129
PK ++Y +S + + W G+ L+ GS YL W ++
Sbjct: 89 ---PKQKKNLELYSQWQKSGQFFLESIAHNITWDPTGSRLLTGSSYLQLWSNTNLEKPTE 145
Query: 130 ----------FGEYKPRLLWSKRQPLPVYLCSITSDSKLISSMNYNDRTVKIWR-----R 174
FG++K +W + V+L + D + ++ +D +K+W R
Sbjct: 146 DENLNKTDLNFGDWK--CIWHCKTASQVHLMKFSPDGEFFATAGKDDCLLKVWYNVENWR 203
Query: 175 VSITSDSDF----------FDLVILPHPDVVTTFRWKTNDHQCNKEHITHVIYTLCADRK 224
++TS F V L HP V F W+ + + +V+ T C D
Sbjct: 204 TAVTSPDGSSEKQSQGEIDFSFVYLAHPRAVNGFSWRKTSKYMPRASVCNVLLTCCKDNV 263
Query: 225 LRVWISFDIDN 235
R+W+ + N
Sbjct: 264 CRLWVETFLPN 274
>Hs21536474 [R] KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit
RAV1/DMX protein WD repeat superfamily
Length = 3027
Score = 141 bits (355), Expect = 8e-33
Identities = 98/319 (30%), Positives = 165/319 (51%), Gaps = 52/319 (16%)
Query: 842 LSKTPLPYLTRHQQVTLISVIEAV----------QEINLNEKVVDINGVRFMLGVKLYTS 891
L + LP L+R +Q++L+++ + + ++ + + +D G++F+L V+L+T
Sbjct: 1493 LLHSSLPGLSRMEQMSLMALADTIATTSTDIGESRDRSQGGETLDECGLKFLLAVRLHTF 1552
Query: 892 -------------HKSTQTSVNMRDVSWATHSDNKEILFSNLFNRLKK----WDNVKEFK 934
H+ TS +WA HS +E L N+ ++K W ++
Sbjct: 1553 LTTSLPAYRAQLLHQGLSTS----HFAWAFHSVAEEELL-NMLPAMQKDDPTWSELRAMG 1607
Query: 935 VPYWAGQQDLV-KCFENIAKFEFNNYDKRDPSRCSIFYLALKKKSILIGLWRISSGHPEQ 993
V +W ++ KC E +AK F Y K DP +IFYLA+KKK+++ GL+R +
Sbjct: 1608 VGWWVRNTRILRKCIEKVAKAAF--YRKNDPLDAAIFYLAMKKKAVIWGLYRAE----KN 1661
Query: 994 AKMLKFLNNDFAEPRWRSAALKNAFVLLSKHRYMDAATFFLLAGSLKDSINVLRKQLNDL 1053
+M +F ++F + RWR AALKNAF LL K R+ +A FFLLAG L+D+I V ++LND+
Sbjct: 1662 TRMTQFFGHNFEDERWRKAALKNAFSLLGKQRFEHSAAFFLLAGCLRDAIEVCLEKLNDI 1721
Query: 1054 DLAIGVCRVYEG--DNGPILHEFLHNQIL----PTAIIDS-------DRWTTSYVYWKMR 1100
LA+ + R+YE D L ++L P + + S D + S YW +
Sbjct: 1722 QLALVIARLYESEFDTSAAYKSILRKKVLGIDSPVSELCSLNINMHHDPFLRSMAYWILE 1781
Query: 1101 KQDLAIKALVQPPVEVDDN 1119
A++ L++ P+ +D+
Sbjct: 1782 DYSGALETLIKQPIRENDD 1800
Score = 69.7 bits (169), Expect = 3e-11
Identities = 58/251 (23%), Positives = 103/251 (40%), Gaps = 50/251 (19%)
Query: 29 AYCSGNNLILLSNRSERLQTI----YLNSDCHAVDVNPRNGLIAVAVSQEVYIYKPLHQI 84
AY SG ++++L + ERLQ I + N VD + + G IA + + I++P++
Sbjct: 30 AYASGCDIVILGSDFERLQIIPGAKHGNIQVGCVDCSMQQGKIAASYGNVISIFEPVNL- 88
Query: 85 MKNPKWVFCCKVYHD---------DSRVNTLQWG-MGNELVLGSDYLSFWDVKDV----- 129
PK ++Y +S + + W G+ L+ GS YL W ++
Sbjct: 89 ---PKQKKNLELYSQWQKSGQFFLESIAHNITWDPTGSRLLTGSSYLQLWSNTNLEKPTE 145
Query: 130 ----------FGEYKPRLLWSKRQPLPVYLCSITSDSKLISSMNYNDRTVKIWR-----R 174
FG++K +W + V+L + D + ++ +D +K+W R
Sbjct: 146 DENLNKTDLNFGDWK--CIWHCKTASQVHLMKFSPDGEFFATAGKDDCLLKVWYNVENWR 203
Query: 175 VSITSDSDF----------FDLVILPHPDVVTTFRWKTNDHQCNKEHITHVIYTLCADRK 224
++TS F V L HP V F W+ + + +V+ T C D
Sbjct: 204 TAVTSPDGSSEKQSQGEIDFSFVYLAHPRAVNGFSWRKTSKYMPRASVCNVLLTCCKDNV 263
Query: 225 LRVWISFDIDN 235
R+W+ + N
Sbjct: 264 CRLWVETFLPN 274
>Hs19745148 [R] KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit
RAV1/DMX protein WD repeat superfamily
Length = 3036
Score = 133 bits (335), Expect = 2e-30
Identities = 124/454 (27%), Positives = 207/454 (45%), Gaps = 69/454 (15%)
Query: 842 LSKTPLPYLTRHQQVTLISVIEAVQEIN--LNEK---------VVDINGVRFMLGVKLYT 890
L + LP LTR +Q+ L+++ + V + L+E +D G+R++L ++L+T
Sbjct: 1518 LMHSSLPGLTRLEQMFLVALADTVATTSTELDESRDKSCSGRDTLDECGLRYLLAMRLHT 1577
Query: 891 SHKST----------QTSVNMRDVSWATHSDNKEILFSNLFNRLKK----WDNVKEFKVP 936
++ V+ +WA HS+ +E L N+ +++ W ++ +
Sbjct: 1578 CLLTSLPPLYRVQLLHQGVSTCHFAWAFHSEAEEELI-NMIPAIQRGDPQWSELRAMGIG 1636
Query: 937 YWAGQ-QDLVKCFENIAKFEFNNYDKRDPSRCSIFYLALKKKSILIGLWRISSGHPEQAK 995
+W L +C E +AK F D ++FYL++KKK+++ GL+R S H E K
Sbjct: 1637 WWVRNINTLRRCIEKVAKASFQR--NNDALDAALFYLSMKKKAVVWGLFR--SQHDE--K 1690
Query: 996 MLKFLNNDFAEPRWRSAALKNAFVLLSKHRYMDAATFFLLAGSLKDSINVLRKQLNDLDL 1055
M F +++F E RWR AALKNAF LL K R+ +A FFLLAGSLKD+I V +++ D+ L
Sbjct: 1691 MTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQSAAFFLLAGSLKDAIEVCLEKMEDIQL 1750
Query: 1056 AIGVCRVYEG--DNGPILHEFLHNQIL---------PTAIIDSDRWTTSYVYWKMRKQDL 1104
A+ + R+YE + L+ +IL + D + S YW M+
Sbjct: 1751 AMVIARLYESEFETSSTYISILNQKILGCQKDGSGFSCKRLHPDPFLRSLAYWVMKDYTR 1810
Query: 1105 AIKALVQPPVEVDDNYKWIEKDKCVNKSF-----LVEDPXXXXXXXXXRDRNIDYYNAAL 1159
A+ L++ + DD ++ I K C +F L P + +
Sbjct: 1811 ALDTLLEQTPKEDDEHQVIIK-SCNPVAFSFYNYLRTHPLLIRRNLASPEGTLATLGLKT 1869
Query: 1160 EVN-----ESLEYEIIMRVATIYTRMGCDYIAVSLLK------DWKFLESKK-----IES 1203
E N +E ++ A + ++GC +A+ +L L +KK I
Sbjct: 1870 EKNFVDKINLIERKLFFTTANAHFKVGCPVLALEVLSKIPKVTKTSALSAKKDQPDFISH 1929
Query: 1204 EQVEIPQSSHSK-LTDNKIEEPVTTQKVRPSLFD 1236
++P SHSK L+D + V S +D
Sbjct: 1930 RMDDVP--SHSKALSDGNGSSGIEWSNVTSSQYD 1961
Score = 55.5 bits (132), Expect = 6e-07
Identities = 51/241 (21%), Positives = 90/241 (37%), Gaps = 43/241 (17%)
Query: 29 AYCSGNNLILLSNRSERLQTI----YLNSDCHAVDVNPRNGLIAVAVSQEVYIYKPL--- 81
AY SG ++++L+N E +Q I + N V+ + + G IA + V I++PL
Sbjct: 30 AYGSGCDIVILANDFECVQIIPGAKHGNIQVSCVECSNQQGRIAASYGNAVCIFEPLGIN 89
Query: 82 ---HQIMKNPKWVFCCKVYHDDSRVNTLQWGMGNELVLGSDYLSFW-------------- 124
+W+ + + N N L+ +D + W
Sbjct: 90 SHKRNCQLKCQWLKTGQFFLSSVTYNLAWDPQDNRLLTTTDSIQLWAPPGDDILEEEEEI 149
Query: 125 --DVKDVFGEYKPRLLWSKRQPLPVYLCSITSDSKLISSMNYNDRTVKIW---------- 172
V V ++K +W + + V+L + D + ++ +D +K+W
Sbjct: 150 DNTVPPVLNDWK--CVWQCKTSVSVHLMEWSPDGEYFATAGKDDCLLKVWYPMTGWKSSI 207
Query: 173 -----RRVSITSDSDFFDLVILPHPDVVTTFRWKTNDHQCNKEHITHVIYTLCADRKLRV 227
V S F V L HP VT F W+ + + +V+ T C D R+
Sbjct: 208 IPQDHHEVKRRQSSTQFSFVYLAHPRAVTGFSWRKTSKYMPRGSVCNVLLTSCHDGVCRL 267
Query: 228 W 228
W
Sbjct: 268 W 268
>At2g46560 [R] KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit
RAV1/DMX protein WD repeat superfamily
Length = 2480
Score = 124 bits (311), Expect = 1e-27
Identities = 98/409 (23%), Positives = 184/409 (44%), Gaps = 48/409 (11%)
Query: 746 HLTSVLNGPLPIYHPQLLIQSL----------------------------FAKKVNLVRE 777
H+ L G LP+YHP L+ ++ +A K L +
Sbjct: 1004 HMVEKLGGALPLYHPHALLVAIRSGNWKRASAALRHLAEYITSSDTSEKGYAVKSVLCPD 1063
Query: 778 ILLKLFHALRKMEFNSDEIHDIG--SSLKLSPSKFLHTNDSTYVFDNYEEPYSTFDSTVS 835
ILL ++ + + G S L S+F S + ++Y D S
Sbjct: 1064 ILLSKYYEGSLSNGPNPKDFQWGGTSGSMLQYSQFQSGLQSKFNMESYSPNSPATDLEFS 1123
Query: 836 APLIDLLSKTPLPYLTRHQQVTLISVIEAVQEINLNEKV-----VDINGVRFMLGVK--- 887
L + ++R + + ++++ + EI+ +D G RF + ++
Sbjct: 1124 GFCEQLKKLSDEGNISRIEILQYFAIVDLLCEISNPHSTSVYASLDEPGRRFWVTLRFKQ 1183
Query: 888 LYTSHKSTQTS------VNMRDVSWATHSDNKEILFSNLFNRLKKWDNVKEFKVPYW-AG 940
L+ + S +T+ ++ + WA HS+++E L +L W ++ +W +
Sbjct: 1184 LFLARSSGKTASLEELDIDSSMIGWAFHSESQENLSGSLLPNESSWQQMRSQGFGFWYSN 1243
Query: 941 QQDLVKCFENIAKFEFNNYDKRDPSRCSIFYLALKKKSILIGLWRISSGHPEQAKMLKFL 1000
L E +A+ ++ ++P C++ Y+AL + +L GL+++S ++ ++ FL
Sbjct: 1244 AAQLRSRMEKLARQQY--LKNKNPKDCALLYIALNRVQVLAGLFKLSKDEKDKP-LVVFL 1300
Query: 1001 NNDFAEPRWRSAALKNAFVLLSKHRYMDAATFFLLAGSLKDSINVLRKQLNDLDLAIGVC 1060
+ +F E + ++AALKNA+VL+ KH+ A FFLL G +INV K L D LA+ +C
Sbjct: 1301 SRNFQEEKNKAAALKNAYVLMGKHQLELAIGFFLLGGEASSAINVCVKNLQDEQLALVIC 1360
Query: 1061 RVYEGDNGPILHEFLHNQILPTAIIDSDRWTTSYVYWKMRKQDLAIKAL 1109
R+ +G G + + ILP+A+ D W S + W++ + +I A+
Sbjct: 1361 RLIDGQGGALESNLIKKYILPSAVQRGDFWLASLLKWELGEYHRSILAM 1409
>CE11074 [R] KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit
RAV1/DMX protein WD repeat superfamily
Length = 2948
Score = 119 bits (297), Expect = 4e-26
Identities = 73/222 (32%), Positives = 117/222 (51%), Gaps = 22/222 (9%)
Query: 873 KVVDINGVRFMLGVKLYT----------SHKSTQTSVNMRDVSWATHSDNKEILFS---N 919
+ VD G+R+++ +K + + ++ ++ ++ WA HS+ + L +
Sbjct: 1557 ETVDECGLRYLMAMKQHEYLMVCLPMKQRMELKKSGLSASNIIWAQHSETETELLNAVPG 1616
Query: 920 LFNRLKKWDNVKEFKVPYWAGQQDLVK-CFENIAKFEFNNYDKRDPSRCSIFYLALKKKS 978
+ W+ +K V +W +K C E IAK F +DP S+FYLAL+KK+
Sbjct: 1617 MHRTNPSWEELKGLGVAWWLKNTASLKICIEKIAKAAFQQ--NQDPMDASLFYLALRKKN 1674
Query: 979 ILIGLWRISSGHPEQAKMLKFLNNDFAEPRWRSAALKNAFVLLSKHRYMDAATFFLLAGS 1038
+L L++ M F NDF + W+ A KNAFVL+SK R+ AA FFLL+GS
Sbjct: 1675 VLTHLFKTI----RNTTMADFFMNDFTKEHWQKVAAKNAFVLMSKQRFQHAAAFFLLSGS 1730
Query: 1039 LKDSINVLRKQLNDLDLAIGVCRVYEGDNGPILHEFLHNQIL 1080
LKD++ L + ND+ LA+ V R+YE D P + + N++L
Sbjct: 1731 LKDAVQTLCSKCNDVQLALVVVRMYESD--PEAQQAMINEVL 1770
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.134 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,239,628
Number of Sequences: 60738
Number of extensions: 3588474
Number of successful extensions: 9564
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 9492
Number of HSP's gapped (non-prelim): 35
length of query: 1363
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1244
effective length of database: 23,161,394
effective search space: 28812774136
effective search space used: 28812774136
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)