ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV5915 check: MH U KOG0928 Intracellular trafficking, secretion, and vesicular transport Pattern-formation protein/guanine nucleotide exchange factor
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV5915 2028791 2032951 1387
(1387 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YEL022w [U] KOG0928 Pattern-formation protein/guanine nucleotide... 1444 0.0
YJR031c [U] KOG0928 Pattern-formation protein/guanine nucleotide... 1155 0.0
SPBC211.03c [U] KOG0928 Pattern-formation protein/guanine nucleo... 423 e-117
At1g13980 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 239 2e-62
At5g39500 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 226 1e-58
At5g19610 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 226 3e-58
CE19701 [U] KOG0928 Pattern-formation protein/guanine nucleotide... 209 2e-53
7303476 [U] KOG0928 Pattern-formation protein/guanine nucleotide... 202 2e-51
Hs4758416 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 183 2e-45
Hs5453573 [U] KOG0929 Guanine nucleotide exchange factor 147 9e-35
YDR170c [U] KOG0929 Guanine nucleotide exchange factor 145 3e-34
At1g01960 [U] KOG0929 Guanine nucleotide exchange factor 143 2e-33
At3g60860 [U] KOG0929 Guanine nucleotide exchange factor 142 4e-33
7298092 [U] KOG0929 Guanine nucleotide exchange factor 141 8e-33
Hs5453571 [U] KOG0929 Guanine nucleotide exchange factor 140 1e-32
At4g38200 [U] KOG0929 Guanine nucleotide exchange factor 130 1e-29
At4g35380 [U] KOG0929 Guanine nucleotide exchange factor 130 2e-29
SPAC30.01c [U] KOG0929 Guanine nucleotide exchange factor 129 3e-29
SPAC4D7.01c [U] KOG0929 Guanine nucleotide exchange factor 128 6e-29
CE24576 [U] KOG0929 Guanine nucleotide exchange factor 126 3e-28
7302131 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin... 113 2e-24
Hs7662290 [U] KOG0931 Predicted guanine nucleotide exchange fact... 112 5e-24
Hs8670546 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 111 7e-24
Hs4758966 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 111 7e-24
Hs8670544 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 111 9e-24
Hs4758964 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 111 9e-24
Hs14764245 [U] KOG0931 Predicted guanine nucleotide exchange fac... 109 3e-23
Hs14767357 [U] KOG0931 Predicted guanine nucleotide exchange fac... 106 2e-22
Hs4758968 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 105 7e-22
7296387 [U] KOG0931 Predicted guanine nucleotide exchange factor... 104 9e-22
Hs7019505 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 104 1e-21
CE12328 [U] KOG0931 Predicted guanine nucleotide exchange factor... 99 4e-20
ECU10g1140 [U] KOG0928 Pattern-formation protein/guanine nucleot... 80 2e-14
Hs4506161 [U] KOG0932 Guanine nucleotide exchange factor EFA6 75 7e-13
Hs6912706 [U] KOG0932 Guanine nucleotide exchange factor EFA6 74 2e-12
Hs22064762 [U] KOG0930 Guanine nucleotide exchange factor Cytohe... 72 5e-12
Hs14150035 [U] KOG0932 Guanine nucleotide exchange factor EFA6 70 2e-11
Hs7662396 [U] KOG0932 Guanine nucleotide exchange factor EFA6 68 1e-10
CE29066 [U] KOG0932 Guanine nucleotide exchange factor EFA6 67 2e-10
CE19234 [U] KOG0932 Guanine nucleotide exchange factor EFA6 67 2e-10
CE26942 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin... 64 2e-09
YPR095c [U] KOG0929 Guanine nucleotide exchange factor 63 3e-09
SPAC26F1.01 [U] KOG0929 Guanine nucleotide exchange factor 61 1e-08
7300886 [U] KOG0932 Guanine nucleotide exchange factor EFA6 61 1e-08
Hs15812208 [U] KOG0929 Guanine nucleotide exchange factor 57 3e-07
>YEL022w [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1459
Score = 1444 bits (3739), Expect = 0.0
Identities = 739/1424 (51%), Positives = 1000/1424 (69%), Gaps = 67/1424 (4%)
Query: 8 RDNVAVDPVTIVIKECISLSTSMRKYAKYSVQSGVAALLGGGSDIFINQDASLAGTFNNL 67
R+ V VDPVTI+IKECI+LST+MRKY+K++ QSGVAALLGGGS+IF NQD LA TFNNL
Sbjct: 4 REFVTVDPVTIIIKECINLSTAMRKYSKFTSQSGVAALLGGGSEIFSNQDDYLAHTFNNL 63
Query: 68 AASKTKDPLLSGLIQLRLMLNHKDNLEDVDALTVLQPFLLVISTASTSGYITSLALDSLQ 127
+K DP LSG IQLRLMLN NL+++D+LT+LQPFLL++ST+S SGYITSLALDSLQ
Sbjct: 64 NTNKHNDPFLSGFIQLRLMLNKLKNLDNIDSLTILQPFLLIVSTSSISGYITSLALDSLQ 123
Query: 128 KFFAFGIINESSKNHVAAYRQTINSLTHCKFEGTEHXXXXXXXXXXXXXIESIIASPSGE 187
KFF IINESS+N++ A+R T+N+LTHC+FEG++ + SI+ SP G+
Sbjct: 124 KFFTLNIINESSQNYIGAHRATVNALTHCRFEGSQQLSDDSVLLKVVFLLRSIVDSPYGD 183
Query: 188 ILSDSCVYDVLQTVMSLACNKRRTDVLRKAAEMSMLSITVKIFDKLKKLDS-SKQHIFIN 246
+LS+S +YDVLQT++SLACN RR++VLR AA+ +M+++TVKIF KLK ++ + I+IN
Sbjct: 184 LLSNSIIYDVLQTILSLACNNRRSEVLRNAAQSTMIAVTVKIFSKLKTIEPVNVNQIYIN 243
Query: 247 DQDFSKNVLKDDNIGA------EGSS-DIDSVENGNFTASSESQNLESD----------- 288
D+ ++ +VLK D IG EGS D ++ N A SE +E +
Sbjct: 244 DESYTNDVLKADTIGTNVESKEEGSQEDPIGMKVNNEEAISEDDGIEEEHIHSEKSTNGA 303
Query: 289 -----------------------YGLAVIKDYMDILVSLLLPENQHKQNNSTKVFGLHLL 325
YGL V++ Y+++L+SL+ PEN+ K + ST++FGL L+
Sbjct: 304 EQLDIVQKTTRSNSRIQAYADDNYGLPVVRQYLNLLLSLIAPENELKHSYSTRIFGLELI 363
Query: 326 NTAIELAGDKFPQHPQLFSLVADPICKNILYIIQNSDKLSLLQAALQLFTNLTIILGDHL 385
TA+E++GD+ +P+LF+L++DPI K+IL+IIQN+ KLSLLQA LQLFT L +ILG++L
Sbjct: 364 QTALEISGDRLQLYPRLFTLISDPIFKSILFIIQNTTKLSLLQATLQLFTTLVVILGNNL 423
Query: 386 SLQIEFTINTIFSILLD----SNVSDETKPRPAVVKELLIEQISILWTRSPSFFTAVFIN 441
LQIE T+ IFSILLD +N S E K +P+++KELLIEQISILWTRSPSFFT+ FIN
Sbjct: 424 QLQIELTLTRIFSILLDDGTANNSSSENKNKPSIIKELLIEQISILWTRSPSFFTSTFIN 483
Query: 442 FDCSLERSDLAIEFLMALTKLSLPESALTTSDSVPPICLEGLISVVDDMHDHFLKAGVQE 501
FDC+L+R+D++I FL ALTKL+LPESALTT++SVPPICLEGL+S+VDDM DH +E
Sbjct: 484 FDCNLDRADVSINFLKALTKLALPESALTTTESVPPICLEGLVSLVDDMFDHMKDIDREE 543
Query: 502 FVPE--ELGTLNKRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNN 559
F + E+ L KR+ KTEFI+C FN+KPKKGIP+LIEKGFI+S+S+ +IA+FLF+NN
Sbjct: 544 FGRQKNEMEILKKRDRKTEFIECTNAFNEKPKKGIPMLIEKGFIASDSDKDIAEFLFNNN 603
Query: 560 ARLNKKTIGEFIAAPEKVGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVE 619
R+NKKTIG + P+KV LL ++I +FDF+GLR+DEAIR LLTKFRLPGESQQIER++E
Sbjct: 604 NRMNKKTIGLLLCHPDKVSLLNEYIRLFDFSGLRVDEAIRILLTKFRLPGESQQIERIIE 663
Query: 620 QFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTF 679
FS+ Y E+Q Y+P + E D ST+QPDADSVF+LSYS+I+LNTD +NPQVK+HM+F
Sbjct: 664 AFSSAYCENQDYDPSKISDNAEDDISTVQPDADSVFILSYSIIMLNTDLHNPQVKEHMSF 723
Query: 680 EDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDDSWNNLIAATTVV 739
EDY+ NLKGC N KDFP WYLD++YCSIRDKEIVMPEEHHG+E+WF+D+WNNLI++TTV+
Sbjct: 724 EDYSGNLKGCCNHKDFPFWYLDRIYCSIRDKEIVMPEEHHGNEKWFEDAWNNLISSTTVI 783
Query: 740 TEAHEVSKCESYVQSLGPNQLIQFDKAIFESVGSSIIETLFKIFEVASDDHIATRMLTTL 799
TE + +S + L P +L+ FD+AIF+ VG SI+ TLF I+ VASDDHI+TRM+T+L
Sbjct: 784 TEIKK--DTQSVMDKLTPLELLNFDRAIFKQVGPSIVSTLFNIYVVASDDHISTRMITSL 841
Query: 800 DKCSNLASLFELGDIYNDVITTMAKFTTLTGERKPVDDVYVDEI----------PVVQID 849
DKCS +++ F+ D++ND++ ++AK TTL ++ + DE+ P+VQI
Sbjct: 842 DKCSYISAFFDFKDLFNDILNSIAKGTTL------INSSHDDELSTLAFEYGPMPLVQIK 895
Query: 850 VEDSKESIAVSNVAILLGNDFKAQLSTVVLFRILRQNTNVALITEVTWNKIIDMLLSLYE 909
ED+ I VS A+ G FK QL+TVV FRI+R+N + + ++ W I++++L+LYE
Sbjct: 896 FEDTNTEIPVSTDAVRFGRSFKGQLNTVVFFRIIRRNKDPKIFSKELWLNIVNIILTLYE 955
Query: 910 NMLITPDIFPDLQVRLKLPNLPKCKPEVLINRSNSSRGLLSTFASYLKGDEEPTDEEIQA 969
+++++PDIFPDLQ RLKL NLPK PE+ IN+S S+GLLSTFASYLKGDEEPT+EEI++
Sbjct: 956 DLILSPDIFPDLQKRLKLSNLPKPSPEISINKSKESKGLLSTFASYLKGDEEPTEEEIKS 1015
Query: 970 STKAMECIKTANISASLFGNDKNVNDTLIKLLLEHIKTEVNDDNKRXXXXXXXXXXXXSV 1029
S KAMECIK++NI+AS+FGN+ N+ LIK LL+ KTE N DN R ++
Sbjct: 1016 SKKAMECIKSSNIAASVFGNESNITADLIKTLLDSAKTEKNADNSRYFEAELLFIIELTI 1075
Query: 1030 SLFLFCKNDAVLGKFLLDKLSSICQNVSLSKNXXXXXXXXXXXXXXX-XENPEYVVKLIN 1088
+LFLFCK + LGKF+L K+ + L+K + EY+ KLIN
Sbjct: 1076 ALFLFCKEEKELGKFILQKVFQLSHTKGLTKRTVRRMLTYKILLISLCADQTEYLSKLIN 1135
Query: 1089 EQLLTKNEVFDNSFFKSQAGANVLQRLLDLAEILNYQGALLHDQGFWKLLRKYAALGTPS 1148
++LL K ++F FF + G L+RL L E Y+G LL ++ FWK LRK A+ S
Sbjct: 1136 DELLKKGDIFTQKFFATNQGKEFLKRLFSLTESEFYRGFLLGNENFWKFLRKVTAMKEQS 1195
Query: 1149 NQVYVFLDTSVMKKKNMIDDVNFMWVLGLFDEMSSVGAVGSQWEEQYNNLVKTGHKVDKE 1208
++ +L+ S+ N++ + NFMWVLGL DE+SS+GAVG+ WE +Y L ++GHK+DKE
Sbjct: 1196 ESIFEYLNESIKTDSNILTNENFMWVLGLLDEISSMGAVGNHWEIEYKKLTESGHKIDKE 1255
Query: 1209 NPYQEIVELSLKSINLTTHLLNTKPTVSKSEIIAIIQALSHQCLNPCFQLRSYAXXXXXX 1268
NPY++ +ELSLKSI LT+HLL + K+EI AIIQAL+HQC+NPC Q+ +A
Sbjct: 1256 NPYKKSIELSLKSIQLTSHLLEDNNDLRKNEIFAIIQALAHQCINPCKQISEFAVVTLEQ 1315
Query: 1269 XXXXXXXPFVDNVISVIALIEMGLYPLTNEVDADSRKAVPLQNFXXXXXXXXXXXXXXEK 1328
+ + SV LIE GL PL N + + + + + K
Sbjct: 1316 TLINKIEIPTNEMESVEELIEGGLLPLLNSSETQEDQKILISSILTIISNVYLHYLKLGK 1375
Query: 1329 TDNETYLKVLSIFNKHVDDGKVEEQLQDMITKKREIEKKQGTPS 1372
T NET+LK+LSIFNK V+D +E++LQ +I K+ IEK G+ S
Sbjct: 1376 TSNETFLKILSIFNKFVEDSDIEKKLQQLILDKKSIEKGNGSSS 1419
>YJR031c [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1408
Score = 1155 bits (2987), Expect = 0.0
Identities = 619/1401 (44%), Positives = 889/1401 (63%), Gaps = 46/1401 (3%)
Query: 11 VAVDPVTIVIKECISLSTSMRKYAKYSVQSGVAALLGGGSDIFINQDASLAGTFNNLAAS 70
+AV+P T+++KECI+L ++M K ++ Q+ VAALLGGGSDIF++Q S +F+NL S
Sbjct: 10 LAVNPATMIVKECINLCSAMNKQSRDKSQTSVAALLGGGSDIFLSQSDSFVDSFHNLPTS 69
Query: 71 KTKDPLLSGLIQLRLMLNHKDNLEDVDALTVLQPFLLVISTASTSGYITSLALDSLQKFF 130
DPL+SGL+QLRL +N L+ ++AL +L+PFL ++S +S SGY TSLALDSLQK F
Sbjct: 70 SYHDPLISGLVQLRLKINDLKGLDSLNALELLKPFLEIVSASSVSGYTTSLALDSLQKVF 129
Query: 131 AFGIINESSKNHVAAYRQTINSLTHCKFEGTEHXXXXXXXXXXXXXIESIIASPSGEILS 190
IIN++ + A R+T+ +LTHC+FE ++ + II S G+ LS
Sbjct: 130 TLKIINKTFNDIQIAVRETVVALTHCRFEASKQISDDSVLLKVVTLLRDIITSSFGDYLS 189
Query: 191 DSCVYDVLQTVMSLACNKRRTDVLRKAAEMSMLSITVKIFDKLKKLD-SSKQHIFINDQD 249
D+ +YDVLQT +SLACN +R++VLRK AE+++ ITVK+F KLK LD +K +IND+
Sbjct: 190 DTIIYDVLQTTLSLACNTQRSEVLRKTAEVTIAGITVKLFTKLKLLDPPTKTEKYINDES 249
Query: 250 FSKNVLKDDNIGAEGS-SDIDSVENGNFTA----------------------SSESQNLE 286
++ N LKDD IG S +D+ S ++ + A + +++N+E
Sbjct: 250 YTDNNLKDDIIGTTTSDNDLSSTDDDSAVADDNKNEKPVQQVIREQENDEETAEKAENVE 309
Query: 287 SDYGLAVIKDYMDILVSLLLPENQHKQNNSTKVFGLHLLNTAIELAGDKFPQHPQLFSLV 346
+YG+ VIKDY+ +L+SL++PEN+ K S L L+N AIE++GDKFP +P+LFSL+
Sbjct: 310 PNYGITVIKDYLGLLLSLVMPENRMKHTTSAMKLSLQLINAAIEISGDKFPLYPRLFSLI 369
Query: 347 ADPICKNILYIIQNSDKLSLLQAALQLFTNLTIILGDHLSLQIEFTINTIFSILLDSNVS 406
+DPI K++L+IIQ+S + SLLQA LQLFT+L +ILGD+L +QIE T+ IF IL D+ +S
Sbjct: 370 SDPIFKSVLFIIQSSTQYSLLQATLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTIS 429
Query: 407 -DETKPRPAVVKELLIEQISILWTRSPSFFTAVFINFDCSLERSDLAIEFLMALTKLSLP 465
D +K +P ++EL+IEQ+SILW SP+FF +F+NFDC+L+RSDL+I+F+ LTK SLP
Sbjct: 430 GDVSKQKPPAIRELIIEQLSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSLP 489
Query: 466 ESALTTSDSVPPICLEGLISVVDDMHDHFLKAGVQEFV--PEELGTLNKRNLKTEFIKCA 523
+A+ TS+++PPICLEG++S+++++++ + EFV +E+ L +R+ KTEFI C
Sbjct: 490 AAAVNTSNNIPPICLEGVLSLIENIYNDLQRFDRAEFVKNQKEIDILKQRDRKTEFILCV 549
Query: 524 EEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVGLLAKF 583
E FN+K KKGI +LIEKGFI S+S +IA FLF NN RLNKKTIG + P+K LL +F
Sbjct: 550 ETFNEKAKKGIQMLIEKGFIDSDSNRDIASFLFLNNGRLNKKTIGLLLCDPKKTSLLKEF 609
Query: 584 IGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYN--------PER 635
I +FDF GLR+DEAIR LLTKFRLPGESQQIER+VE FS+KY DQ + +
Sbjct: 610 IDLFDFKGLRVDEAIRILLTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGK 669
Query: 636 DGLE--IEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQK 693
+G E E D +QPDADSVFVLSYS+I+LNTD +NPQVK HMTF+DY+ NL+GC N K
Sbjct: 670 NGSESMTEDDIIHVQPDADSVFVLSYSIIMLNTDSHNPQVKDHMTFDDYSNNLRGCYNGK 729
Query: 694 DFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDDSWNNLIAATTVVTEAHEVSKCESYVQ 753
DFP WYL K+Y SI+ KEIVMPEEHHG+ERWF+D+WNNLI++T+V+TE + +
Sbjct: 730 DFPRWYLHKIYTSIKVKEIVMPEEHHGNERWFEDAWNNLISSTSVMTEMQR--DFTNPIS 787
Query: 754 SLGPNQLIQFDKAIFESVGSSIIETLFKIFEVASDDHIATRMLTTLDKCSNLASLFELGD 813
L ++Q++KAIF +V I++TLFKIF VAS D I+ R+L + KC+ + F
Sbjct: 788 KLAQIDILQYEKAIFSNVRDIILKTLFKIFTVASSDQISLRILDAISKCTFINYYFSFDQ 847
Query: 814 IYNDVITTMAKFTTLTGERKPVDDVYVDEIPVVQIDVEDSKESIAVSNVAILLGNDFKAQ 873
YND + + + TTL ++ VD IP+V+I VED+ I+VSN +I LG +FKAQ
Sbjct: 848 SYNDTVLHLGEMTTLAQSSAKAVELDVDSIPLVEIFVEDTGSKISVSNQSIRLGQNFKAQ 907
Query: 874 LSTVVLFRILRQNTNVALITEVTWNKIIDMLLSLYENMLITPDI--FPDLQVRLKLPNLP 931
L TV+ F+I+++ ++ ++++ WN+I+ ++L L+EN+L+ P++ F + LKLP LP
Sbjct: 908 LCTVLYFQIIKEISDPSIVSTRLWNQIVQLILKLFENLLMEPNLPFFTNFHSLLKLPELP 967
Query: 932 KCKPEVLINRSNSSRGLLSTFASYLKGDEEPTDEEIQASTKAMECIKTANISASLFGNDK 991
P++ I ++ SR LLSTFASYLKGDEEP++E+I S KA EC+K ++ +S+F N++
Sbjct: 968 LPDPDISIRKAKMSRSLLSTFASYLKGDEEPSEEDIDFSIKAFECVKASHPLSSVFENNQ 1027
Query: 992 NVNDTLIKLLLEHIKTEVNDDNKRXXXXXXXXXXXXSVSLFLFCKNDAVLGKFLLDKLSS 1051
V+ +I+ LL + E +N S+ L G + D + +
Sbjct: 1028 LVSPKMIETLLSSLVIEKTSENSPYFEQELLFLLEISIILISEASYGQEFGALIADHMIN 1087
Query: 1052 ICQNVSLSKNXXXXXXXXXXXXXXXXENPEYVVK-LINEQLLTKNEVFDNSFFKSQAGAN 1110
I LSK +NP ++ LI L KNE+F+ +++S+ G
Sbjct: 1088 ISNLDGLSKEAIARLASYKMFLVSRFDNPRDILSDLIEHDFLVKNEIFNTKYYESEWGKQ 1147
Query: 1111 VLQRLLDLAEILNYQGALLHDQGFWKLLRKYAALGTPSNQVYVFLDTSVMKKKNMIDDVN 1170
V+ L + Y L + FW LR + VY FL+ + +DD N
Sbjct: 1148 VINDLFTHLNDVKYNERALKNVKFWNFLRILISAKDRQFAVYTFLEKYIQNGDIFVDDGN 1207
Query: 1171 FMWVLGLFDEMSSVGAVGSQWEEQYNNLVKTGHKVDKENPYQEIVELSLKSINLTTHLLN 1230
FM +L L DEMS GAVG++WE+ Y N V+ G + + NPY+ I++LS +SIN+T LL+
Sbjct: 1208 FMNILSLLDEMSCAGAVGTKWEQNYENSVEDGCEAPESNPYRSIIDLSSRSINITADLLS 1267
Query: 1231 T----KPTVSKSEIIAIIQALSHQCLNPCFQLRSYAXXXXXXXXXXXXXPFVDNVISVIA 1286
T ++K+EIIA IQ L+HQCLNPC +L A ++V
Sbjct: 1268 TVGRSNSALNKNEIIAAIQGLAHQCLNPCDELGMQALQALENILLSRASQLRTEKVAVDN 1327
Query: 1287 LIEMGLYPLTNEVDADSRKAVPLQNFXXXXXXXXXXXXXXEKTDNETYLKVLSIFNKHVD 1346
L+E GL P+ + K + + T NET+L+VL++FNK+VD
Sbjct: 1328 LLETGLLPIFELDEIQDVKMKRITSILSVLSKIFLGQLVEGVTSNETFLRVLNVFNKYVD 1387
Query: 1347 DGKVEEQLQDMITKKREIEKK 1367
D VE QLQ++I KREIEK+
Sbjct: 1388 DPTVERQLQELIISKREIEKE 1408
>SPBC211.03c [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1462
Score = 423 bits (1087), Expect = e-117
Identities = 317/1041 (30%), Positives = 508/1041 (48%), Gaps = 142/1041 (13%)
Query: 12 AVDPVTIVIKECISLSTSMRKYAKYSVQSGVAALLGGGS--DIFINQDASLAGTFNNLAA 69
++ P ++VI E I++ T++RK ++ SGVA++LG + D F+ N +
Sbjct: 15 SISPSSLVINEIITVVTAIRKTTRWR-NSGVASILGVSTLKDEFLADGLESRWKTNGEKS 73
Query: 70 SKTKDPLLSGLIQLRLMLNHKDNLEDVDALTVLQPFLLVISTASTSGYITSLALDSLQKF 129
S + PL+ QL+ L ++ +L D+L +L PFL I + +GYITSL L ++ KF
Sbjct: 74 SSIRYPLVMEFSQLKEDLTNRASLNGYDSLKLLSPFLRTIKSPRMTGYITSLCLSAILKF 133
Query: 130 FAFGIINESSKNHVAAYRQTINSLTHCKFEGTEHXXXXXXXXXXXXXIESIIASPSGEIL 189
F+F II+E S N + R ++T C+FE + +E ++ P +L
Sbjct: 134 FSFRIISEESPNLALSMRNLSFAITQCRFESFDASQDEAVLLRVSRLMEELLRGPGKAVL 193
Query: 190 SDSCVYDVLQTVMSLACNKRRTDVLRKAAEMSMLSITVKIFDKLKKLDSSKQHIFINDQD 249
SD + ++++T +S+ C R + VLR +AE+SM SI KIF++LK +D
Sbjct: 194 SDDSICEIVETGLSMCCQSRLSQVLRYSAELSMTSILEKIFERLKYID------------ 241
Query: 250 FSKNVLKDDNIGAEGSSDIDSVENGNF-----TASSESQNLESDYGLAVIKDYMDILVSL 304
+K D+ +S+ S++ F T E N +G+ I++ +LVS
Sbjct: 242 -----VKTDSEDFWDASEEHSIKGEEFHYKKITEGDEISNEIDPFGIGSIREVFRVLVSF 296
Query: 305 LLPENQHKQNNSTKVFGLHLLNTAIELAGDKFPQHPQLFSLVADPICKNILYIIQNSDKL 364
+ + K +++ K L +NTA+E++G P L L+ D +CK++L +I+ SD
Sbjct: 297 I-DFGKQKFSDNIKAMALRFINTALEVSGSHISDFPSLRVLITDTLCKSLLQLIR-SDHT 354
Query: 365 SLLQAALQLFTNLTIILGDHLSLQIEFTINTIFSIL------------------------ 400
+LL +L + T L + L LQ E I+ + S L
Sbjct: 355 ALLTNSLLVMTTLLQAMPGSLKLQQELFISYLISCLHIPSTTPRERNVETSLHKVVSSLD 414
Query: 401 LDSNVSDE----------------TKPRPAVVKELLIEQISILWTRSPSFFTAVFINFDC 444
L +S + T+ RP V+EL++E + L +R P F +++N+DC
Sbjct: 415 LSEEISPDRATPTSFTERKRFAFDTRNRPPEVRELIVECLGSL-SRIPYFLIDLYVNYDC 473
Query: 445 SLERSDLAIEFLMALTKLSLPESALTTSDSVPPICLEGLISVVDDMHDHFLKA------G 498
+ SDLAI+ L LT+ L +SA ++ +VPP+CL+ L++ + H+H
Sbjct: 474 DPQMSDLAIDLLKVLTRNCLVDSARYSTANVPPLCLDALLNFIYYFHEHLQPCYNDPNNT 533
Query: 499 VQEFVPEELGTLNKRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDN 558
++ V + L KR K I+ AE FN+ P GI L + I + F +
Sbjct: 534 FKDDVAKTLIESKKR--KAIIIEGAELFNESPSDGIAFLTQHSIIKQSDNPTCIVEFFHS 591
Query: 559 NARLNKKTIGEFIAAPEKVGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVV 618
RL+K+ +GEF+ +L FI FDF G RIDEA+R LL FRLPGESQ IERV+
Sbjct: 592 TNRLSKRVLGEFLTKGSNSHILNAFISAFDFKGKRIDEALRLLLQSFRLPGESQLIERVL 651
Query: 619 EQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDA----DSVFVLSYSVIILNTDFYNPQVK 674
E FS HY Y + PD+ D+ FVLSYS+I+LNTD +NP +K
Sbjct: 652 ETFS-------HY------------YMSANPDSMSSKDAAFVLSYSIIMLNTDQHNPNIK 692
Query: 675 --KHMTFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDDSWNNL 732
+ MT +D+ N++G N+ +DF +L ++Y +I++ EI++ EE H +E F W+ L
Sbjct: 693 SQRRMTLDDFCRNVRGVNDGQDFDRNFLSEIYKAIKENEIIVAEE-HDTELSFLYIWSKL 751
Query: 733 IAATTVVTEAHEVSKCESYVQSLGPNQLIQFDKAIFESVGSSIIETLFKIFEVASDDHIA 792
+ +TE + S + DK +F V SI+ L +F A++D +
Sbjct: 752 -QQSVKITEPFKRSSSNVH------------DKIVFLEVWKSIMAALIYVFSTATEDTVF 798
Query: 793 TRMLTTLDKCSNLASLFELGDIYNDVITTMAKFTTLTGERKPVDDVYVDEIPVVQIDVED 852
R++ + + + +A+ +EL + + I +FT L P + I VED
Sbjct: 799 YRVVNGIQQATEVAAAYELNEPVDYAIERFCQFTALDPSSVPGTQLN------TAIKVED 852
Query: 853 SKESIAVSNVAILLGNDFKAQLSTVVLFRILRQNTNVALITEVTWNKIIDMLLSLYENML 912
I VS +++ G DF+AQL+ +VLF I + N I + +W ++ + + L N L
Sbjct: 853 --RIITVSELSVRFGRDFRAQLALLVLFWISSKFGN---IIDASWPLLVQLTICLARNNL 907
Query: 913 ITPDIFPDLQV------RLKLPNLPKCKPEVLINRSNSSRGLLSTFASYLK---GDEE-- 961
I P ++ P L KP + + GLLS +SYL DE
Sbjct: 908 IDNSFLPGFKLFGYQWFPFPEPPLNSGKPAL-----SKEGGLLSALSSYLSSYANDEPPC 962
Query: 962 PTDEEIQASTKAMECIKTANI 982
PTDEEIQ + ++CI +A I
Sbjct: 963 PTDEEIQHTLCTIDCISSAKI 983
>At1g13980 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1451
Score = 239 bits (610), Expect = 2e-62
Identities = 234/982 (23%), Positives = 423/982 (42%), Gaps = 156/982 (15%)
Query: 96 VDALTVLQPFLLVISTASTSGYITSLALDSLQKFFAFGIINESSKNHVAAYRQTINSLTH 155
+ + LQPFL VI + T ITS+AL S+ K +I++++ N A ++S+T
Sbjct: 88 ISPMLYLQPFLDVIRSDETGAPITSIALSSVYKILNLNVIDQNTANIEDAMHLVVDSVTS 147
Query: 156 CKFEGTEHXXXXXXXXXXXXXIESIIASPSGEILSDSCVYDVLQTVMSLACNK-RRTDVL 214
C+FE T+ + + + + + +LS+ V V+ T + + ++L
Sbjct: 148 CRFEVTDPASEEVVLMKILQVLLACMKNKASVMLSNQHVCTVVNTCFRVVHQAGMKGELL 207
Query: 215 RKAAEMSMLSITVKIFDKLKKLD-----------SSKQHIFINDQDFS--KNVLKDDNIG 261
++ A +M + IF L ++ S KQ D D++ ++D N
Sbjct: 208 QRVARHTMHELVRCIFSHLPDVERTETTLVNRAGSIKQEKAGVDSDYAIVSKPVEDGNAN 267
Query: 262 AEGSSDIDSVENGNFTASSESQNLESD----------------------YGLAVIKDYMD 299
+E VEN T ++ +Q+L D YG+ + +
Sbjct: 268 SEYD-----VENSMATFATGAQSLMDDGPVGPGSRKPASPYDLHIMTEPYGVPSMVEIFH 322
Query: 300 ILVSLL---------LPENQHKQNNSTKVFGLHLLNTAIELAGDKFPQHPQLFSLVADPI 350
L SLL N + +F L+L+N+AIEL G HP+L SL+ D +
Sbjct: 323 FLCSLLNVVEHVGMGSRSNTIAFDEDVPLFALNLINSAIELGGSSIRHHPRLLSLIQDEL 382
Query: 351 CKNILYIIQNSDKLSLLQAALQLFTNLTIILGDHLSLQIEFTINTIFSILLDSNVSDETK 410
+N++ LS+ L + ++ + L HL +++ + FS ++ + K
Sbjct: 383 FRNLMQF-----GLSMSPLILSMVCSIVLNLYQHLRTELKLQLEAFFSCVILRLA--QGK 435
Query: 411 PRPAVVKELLIEQISILWTRSPSFFTAVFINFDCSLERSDLAIEFLMALTKLSLPESALT 470
P+ ++ + + + + R SF ++ N DC + S++ E L+K + P +
Sbjct: 436 YGPSYQQQEVAMEALVNFCRQKSFMVEMYANLDCDITCSNVFEELSNLLSKSTFPVNCPL 495
Query: 471 TSDSVPPICLEGLISVVDDMHDHF------LKAG---VQEFVPEELGTLN---------- 511
++ + + L+GLI+V+ M + L G + E+ P + +
Sbjct: 496 SAMHI--LALDGLIAVIQGMAERISNGLTGLDLGPVHLDEYTPFWMVKCDNYSDPNHWVS 553
Query: 512 ----KRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTI 567
++ +K + A+ FN+ PKKG+ L + + + F A L+K +
Sbjct: 554 FVRRRKYIKRRLMIGADHFNRDPKKGLEFLQGTHLLPDKLDPQSVACFFRYTAGLDKNLV 613
Query: 568 GEFIAAPEK--VGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKY 625
G+F+ ++ V +L +F G FDF + +D A+R L FRLPGESQ+I+RV+E FS +Y
Sbjct: 614 GDFLGNHDEFCVQVLNEFAGTFDFQYMNLDTALRLFLETFRLPGESQKIQRVLEAFSERY 673
Query: 626 VEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLN 685
+PE I + D+ VLSYS+I+LNTD +N QVKK MT ED+ N
Sbjct: 674 YMQ---SPE------------ILANKDAALVLSYSIIMLNTDQHNVQVKKKMTEEDFIRN 718
Query: 686 LKGCNNQKDFPLWYLDKVYCSIRDKEI-VMPEEHHGSERWFDDSWNNLIAATTVVTEAHE 744
+ N D P +L +++ SI + EI PE+ G W +L+ H+
Sbjct: 719 NRHINGGNDLPREFLSELFHSICNNEIRTTPEQGAGFPEMTPSRWIDLM---------HK 769
Query: 745 VSKCESYVQSLGPNQLIQFDKAIFESVGSSIIETLFKIFEVASDDHIATRMLTTLDKCSN 804
K Y+ + + D +F + I + +F+ A + + + +
Sbjct: 770 SKKTAPYILA---DSRAYLDHDMFAIMSGPTIAAISVVFDHAEHEDVYQTCIDGFLAIAK 826
Query: 805 LASLFELGDIYNDVITTMAKFTTLTGERKPVDDVYVDEIPVVQIDVEDSKESIAVSNVAI 864
+++ L D+ +D++ ++ KFTTL ++ VDE PV +
Sbjct: 827 ISACHHLEDVLDDLVVSLCKFTTL------LNPSSVDE-PV------------------L 861
Query: 865 LLGNDFKAQLSTVVLFRILRQNTNVALITEVTWNKIIDMLLSLYENMLITPDIFPDLQVR 924
G+D KA+++T+ +F I + + W I+D +L L++ L+ + D
Sbjct: 862 AFGDDAKARMATITIFTIANKYGD---YIRTGWRNILDCILRLHKLGLLPARVASDAADE 918
Query: 925 LK----------LPNLPKCKPEVLINRSNSSRGLLSTFASYLKGDEE-----PTDEEIQA 969
+ L N + S GL+ F+ L D E PT++++ A
Sbjct: 919 SEHSSEQGQGKPLANSLSSAHLQSMGTPRRSSGLMGRFSQLLSLDTEEPRSQPTEQQLAA 978
Query: 970 STKAMECIKTANISASLFGNDK 991
+ ++ I+ +I S+F K
Sbjct: 979 HQRTLQTIQKCHID-SIFTESK 999
>At5g39500 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1443
Score = 226 bits (577), Expect = 1e-58
Identities = 233/1028 (22%), Positives = 426/1028 (40%), Gaps = 162/1028 (15%)
Query: 76 LLSGLIQLRLML-NHKDNLEDVDALTVLQPFLLVISTASTSGYITSLALDSLQKFFAFGI 134
L+ L +LR + + + N + VD +QPFL VI + T IT +AL S+ K +
Sbjct: 65 LIHSLKELRKQIFSWQSNWQYVDPRLYIQPFLDVILSDETGAPITGVALSSVYKILTLEV 124
Query: 135 INESSKNHVAAYRQTINSLTHCKFEGTEHXXXXXXXXXXXXXIESIIASPSGEILSDSCV 194
+ N A ++++ C+FE T+ + + + S + LS+ +
Sbjct: 125 FTLETVNVGEAMHIIVDAVKSCRFEVTDPASEEVVLMKILQVLLACVKSKASNGLSNQDI 184
Query: 195 YDVLQTVMSLAC-NKRRTDVLRKAAEMSMLSITVKIFDKLKKLDSSKQHIFINDQDFSKN 253
++ T + + + ++++L++ A +M + IF +L + ++ +
Sbjct: 185 CTIVNTCLRVVHQSSSKSELLQRIARHTMHELIRCIFSQLPFISPLANECELHVDNKVGT 244
Query: 254 VLKDDNIGAEGSSDIDSVENGNFTASSESQNLESD------------------------- 288
V D N G + VENGN + S++ + D
Sbjct: 245 VDWDPNSGEK------RVENGNIASISDTLGTDKDDPSSEMVIPETDLRNDEKKTEVSDD 298
Query: 289 --------------YGLAVIKDYMDILVSLL-LPENQHKQNNSTKV--------FGLHLL 325
YG+ + + L +LL + EN + S + F L L+
Sbjct: 299 LNAAANGENAMMAPYGIPCMVEIFHFLCTLLNVGENGEVNSRSNPIAFDEDVPLFALGLI 358
Query: 326 NTAIELAGDKFPQHPQLFSLVADPICKNILYIIQNSDKLSLLQAALQLFTNLTIILGDHL 385
N+AIEL G F +HP+L +L+ D + N++ + L +L + NL + L L
Sbjct: 359 NSAIELGGPSFREHPKLLTLIQDDLFCNLMQFGMSMSPL-ILSTVCSIVLNLYLNLRTEL 417
Query: 386 SLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLIEQISILWTRSPSFFTAVFINFDCS 445
+Q+E + + + S + + V E L++ R +F VF NFDC
Sbjct: 418 KVQLEAFFSYVLLRIAQSKHGSSYQQQE-VAMEALVDLC-----RQHTFIAEVFANFDCD 471
Query: 446 LERSDLAIEFLMALTKLSLPESALTTSDSVPPICLEGLISVVDDMHDHFLKAGVQEFVP- 504
+ S++ + L+K + P + ++ + + L+GLIS+V M + + VP
Sbjct: 472 ITCSNVFEDVSNLLSKNAFPVNGPLSAMHI--LALDGLISMVQGMAERVGEELPASDVPT 529
Query: 505 -----EELGTLNKRN----------------LKTEFIKCAEEFNKKPKKGIPLLIEKGFI 543
EE T+ N +K + + A+ FN+ P KG+ L +
Sbjct: 530 HEERYEEFWTVRCENYGDPNFWVPFVRKVKHIKKKLMLGADRFNRDPNKGLQYLQGVHLL 589
Query: 544 SSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEK--VGLLAKFIGMFDFTGLRIDEAIRAL 601
+ + F L+K +G+F+ ++ + +L +F FDF + + A+R
Sbjct: 590 PEKLDPKSVACFFRYTCGLDKNVMGDFLGNHDQFCIQVLHEFAKTFDFQNMNLATALRLF 649
Query: 602 LTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSV 661
+ F+L GE+Q+I RV+E FS +Y E + I D D+ FVL+YS+
Sbjct: 650 VGTFKLSGEAQKIHRVLEAFSERYYEQSPH---------------ILIDKDAAFVLAYSI 694
Query: 662 IILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGS 721
I+LNTD +N QVK MT ED+ N + N D P YL ++Y SIR EI M E+
Sbjct: 695 ILLNTDQHNAQVKTRMTEEDFIRNNRTINGGADLPREYLSEIYHSIRHSEIQMDED---- 750
Query: 722 ERWFDDSWNNLIAATTVVTEAHEVSKCESYVQSLGPNQLIQFDKAIFESVGSSIIETLFK 781
+ L+ A+ ++ ++ + Y+Q + L D+ +F V I
Sbjct: 751 ----KGTGFQLMTASRWISVIYKSKETSPYIQCDAASHL---DRDMFYIVSGPTIAATSV 803
Query: 782 IFEVASDDHIATRMLTTLDKCSNLASLFELGDIYNDVITTMAKFTTLTGERKPVDDVYVD 841
+FE A + + R + L + L++ + L + +D++ ++ KFT
Sbjct: 804 VFEQAEQEDVLRRCIDGLLAIAKLSAYYHLNSVLDDLVVSLCKFTPFFA----------- 852
Query: 842 EIPVVQIDVEDSKESIAVSNVAILLGNDFKAQLSTVVLFRILRQNTNVALITEVTWNKII 901
++ ++LG D +A+++T +F I + + W I+
Sbjct: 853 --------------PLSADEAVLVLGEDARARMATEAVFLIANKYGD---YISAGWKNIL 895
Query: 902 DMLLSLYENMLITPDIF-------PDLQVRLKLPNLPKCKPEVLINRS------NSSRGL 948
+ +LSL + I PD P+L P P ++++S S
Sbjct: 896 ECVLSL-NKLHILPDHIASDAADDPELSTSNLEQEKPSANPVPVVSQSQPSAMPRKSSSF 954
Query: 949 LSTFASYLKGDEE---PTDEEIQASTKAMECIKTANISASLFGNDKNVN-DTLIKLLLEH 1004
+ F +E P++EE+ A A +K +I S+F + K + ++L +L+
Sbjct: 955 IGRFLLSFDSEETKPLPSEEELAAYKHARGIVKDCHID-SIFSDSKFLQAESLQQLVNSL 1013
Query: 1005 IKTEVNDD 1012
I+ D+
Sbjct: 1014 IRASGKDE 1021
>At5g19610 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1375
Score = 226 bits (575), Expect = 3e-58
Identities = 199/792 (25%), Positives = 337/792 (42%), Gaps = 120/792 (15%)
Query: 85 LMLNHKDNLEDVDALTVLQPFLLVISTASTSGYITSLALDSLQKFFAFGIINESSKNHVA 144
L+ N + + +D L PFL VI + T++AL S+ K I +E +
Sbjct: 61 LIFNPQQDWRTIDPSVYLSPFLEVIQSDEIPASATAVALSSILKILKIEIFDEKTPGAKD 120
Query: 145 AYRQTINSLTHCKFEGTEHXXXXXXXXXXXXXIESIIASPSGEILSDSCVYDVLQTVMSL 204
A ++ +T C+ E T+ + I+ PS E+L D V ++ T +
Sbjct: 121 AMNSIVSGITSCRLEKTDLVSEDAVMMRILQVLTGIMKHPSSELLEDQAVCTIVNTCFQV 180
Query: 205 ACNKR-RTDVLRKAAEMSMLSITVKIFDKLKKLDSSKQHIFINDQDFSKNVLKDDNIGAE 263
R D+L++ +M + IF +L + ++ D G +
Sbjct: 181 VQQSTGRGDLLQRNGRYTMHELIQIIFSRLPDFE-----------------VRGDEGGED 223
Query: 264 GSSDIDSVENGNFTASSESQNLESDYGLAVIKDYMDILVSLLLP---------ENQHKQN 314
SD D ++ + YG+ D L SLL N H +
Sbjct: 224 SESDTDEID------------MSGGYGIRCCIDIFHFLCSLLNVVEVVENLEGTNVHTAD 271
Query: 315 NSTKVFGLHLLNTAIELAGDKFPQHPQLFSLVADPICKNILYIIQNSDKLSLLQAALQLF 374
++F L L+N+AIEL+GD QHP+L +V D + ++++ +S L +L
Sbjct: 272 EDVQIFALVLINSAIELSGDAIGQHPKLLRMVQDDLFHHLIHYGASSSPL-VLSMICSCI 330
Query: 375 TNLTIILGDHLSLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLIEQISILWTRSPSF 434
N+ L + LQ+E FS +L V+ T P ++E+ +E + I + R P+F
Sbjct: 331 LNIYHFLRKFMRLQLE----AFFSFVL-LRVTAFTGFLP--LQEVALEGL-INFCRQPAF 382
Query: 435 FTAVFINFDCSLERSDLAIEFLMALTKLSLPESALTTSDSVPPICLEGLISVV------- 487
++N+DC ++ E L + + P S TS + EGL+ ++
Sbjct: 383 IVEAYVNYDCDPMCRNIFEETGKVLCRHTFPTSGPLTSIQIQ--AFEGLVILIHNIADNM 440
Query: 488 ----------DDMHDHFLKAG---VQEFVP-------EELGTLN-----KRNLKTEFIKC 522
DD + + +K + E++P E+ T ++ K +
Sbjct: 441 DREEDEGNEEDDNNSNVIKPSPVEIHEYIPFWIDKPKEDFETWVDHIRVRKAQKRKLAIA 500
Query: 523 AEEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVGL--L 580
A FN+ KKG+ L +S + F L+K IG+++ P+++ L L
Sbjct: 501 ANHFNRDEKKGLEYLKYNYLVSDPLDPMALASFFRFTPGLDKTMIGDYLGDPDELHLSVL 560
Query: 581 AKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEI 640
F F+FTG+ +D A+R L FRLPGESQ+IER++E FS ++ + Q
Sbjct: 561 RSFTHTFEFTGMNLDTALRTFLESFRLPGESQKIERMIEAFSERFYDQQS---------- 610
Query: 641 EGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYL 700
S I D+V +L YS+I+LNTD +NPQV++ MT +++ N + N D P YL
Sbjct: 611 ----SDIFASKDTVHILCYSLIMLNTDQHNPQVRRKMTEDEFIRNNRAINAGNDLPKEYL 666
Query: 701 DKVYCSIRDKEIVMPEEHHGSERWFDDSWNNLIAATTVVTEAHEVSKCESYVQSLGPNQL 760
+++ SI + H G + W L+ T ++ P L
Sbjct: 667 SELFQSIATNAFAL-STHSGPVEMNPNRWIELMNRT----------------KTTQPFSL 709
Query: 761 IQFDKAI----FESVGSSIIETLFKIFEVASDDHIATRMLTTLDKCSNLASLFELGDIYN 816
QFD+ I F ++ I + FE + DD + + + + +A + L DI +
Sbjct: 710 CQFDRRIGRDMFATIAGPSIAAVSAFFEHSDDDEVLHECVDAMISIARVAQ-YGLEDILD 768
Query: 817 DVITTMAKFTTL 828
++I + KFTTL
Sbjct: 769 ELIASFCKFTTL 780
>CE19701 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1820
Score = 209 bits (533), Expect = 2e-53
Identities = 199/791 (25%), Positives = 342/791 (43%), Gaps = 124/791 (15%)
Query: 289 YGLAVIKDYMDILVSLLLPENQHKQNNSTKVFGLHLLNTAIELAGDKFPQHPQLFSLVAD 348
YGL ++ + L+++ P ++H S + GL+LL A+E D P + L L+ +
Sbjct: 384 YGLPCCRELLRFLITMTNPVDRHN-TESMVILGLNLLIVALEAIADFLPNYDILMPLIKN 442
Query: 349 PICKNILYIIQNSDKLSLLQAALQLFTNLTIILGDHLSLQIEFTINTIFSILLDSNVSDE 408
+C+N+L ++ ++++L +L A + L + H+ Q+E + + SI+L E
Sbjct: 443 ELCRNLLQLL-DTNRLPVLAATNRCCFLLFESMRMHMKFQLESYLKKLQSIVLTEEKQHE 501
Query: 409 TKPRPAVVKELLIEQISILWTRSPSFFTAVFINFDCSL---------------------- 446
KE+ +E + LW R P T +++NFDC L
Sbjct: 502 NGGGGTEQKEMALESLVQLW-RIPGLVTEMYLNFDCDLYCGNIFEDLTKLLVENSFPTVG 560
Query: 447 --ERSDLAIEFLMA---------------------------LTKLSLP---------ESA 468
S L+++ L+ L KL LP + A
Sbjct: 561 GHTASLLSLDALLVVIETIEQNCEDRENGRGEVAKEQEHKDLKKLGLPVLSGYDLAKKMA 620
Query: 469 LTTSDSVPPICLEGLISVVDDMHDHFLKAGVQEFVPEELGTLNKRNLKTEFIKCAEEFNK 528
++T P+ + I + + H + +P + ++ K + E FN+
Sbjct: 621 ISTGGKASPMPVSSSIVLRSNRHAPSTE------LPSMSQIIEQKKRKRLIAEGTELFNQ 674
Query: 529 KPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVGLLAKFIGMFD 588
PKKGI L EKG + + E + ++L N +L+KK I ++I + +L F+ F
Sbjct: 675 SPKKGIAFLREKGILG-HDEQSLVQWL-RTNPQLDKKAIADYICNRKHAEVLNAFVKSFP 732
Query: 589 FTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQ 648
F R+D A+R L FRLPGES +I V++ FS ++ + +
Sbjct: 733 FENTRLDVALRMFLETFRLPGESAEIALVMQHFSEEWFRANN-----------------E 775
Query: 649 P--DADSVFVLSYSVIILNTDFYNPQVKKH---MTFEDYTLNLKGCNNQKDFPLWYLDKV 703
P D+ F LSY++I+LN D +NPQ K+ MT + + NL G N+ +DF L +
Sbjct: 776 PFFHVDAAFTLSYAIIMLNVDQHNPQAKRSQPPMTVDCFRRNLSGTNDSRDFDPEMLADM 835
Query: 704 YCSIRDKEIVMPEEHHGSERWFDDSWNNLIAATTVVTEAHEVSKCESYVQSLGPNQLIQF 763
Y +I+ +EIVMP E G+ + D W V+ E ++ Y G N
Sbjct: 836 YQAIKTEEIVMPAEQKGTVK-EDYMWK-------VLLRRGETAEGSFYHAPTGWN----- 882
Query: 764 DKAIFESVGSSIIETLFKIFEVASDDHIATRMLTTLDKCSNLASLFELGDIYNDVITTMA 823
D +F + L +F+ + + I + LT KC+ +A+ + + ++++++ +
Sbjct: 883 DHDLFAVCWGPAVAALSYVFDKSEHEQILQKALTGYRKCAKIAAYYGMKEVFDNLCIHLC 942
Query: 824 KFTTLTGERKPVDDVYVDEIPVVQIDVEDS---KESIAVSNVAILLGNDFKAQLSTVVLF 880
KFTTLT R DE +D+ + S + VA+ G + KAQL+T LF
Sbjct: 943 KFTTLTSMRDGGAGGGADE----DVDLSAAALLSHSSSPEAVALAFGENHKAQLATRTLF 998
Query: 881 RILRQNTNVALITEVTWNKIIDMLLSLYENMLITPDI--FPDLQVRLKLPNLPKCKPEVL 938
++ +N N I W + + LL L+ L+ ++ D N+ + + L
Sbjct: 999 YLVHENGN---ILREGWRNLFEALLQLFRARLLPAELTEVEDYVDEKGWVNIQRVHQKEL 1055
Query: 939 INRSNSSRGLLSTFASYLKGDE----EPTDEEIQASTKAMECIKTANISASLFGNDKNVN 994
+ N S GLLS F E +PT E++ + A + I S + + K +
Sbjct: 1056 PHTRNDS-GLLSWFGLGGGASEADRRKPTQEQLSSMKLASQVISECRPS-QIVADSKYLT 1113
Query: 995 DTLIKLLLEHI 1005
T + LL I
Sbjct: 1114 STSLAELLSSI 1124
Score = 74.7 bits (182), Expect = 9e-13
Identities = 54/203 (26%), Positives = 87/203 (42%), Gaps = 31/203 (15%)
Query: 74 DPLLSGLIQLRLMLNHKDNLEDVDALTVLQPFLLVISTASTSGYITSLALDSLQKFFAFG 133
DPLL L+ +LN +L D++ T L PFL VI +T+G IT AL ++ KF +G
Sbjct: 39 DPLLRNFTDLKEVLNEVADLADMNPQTYLSPFLDVIKAQNTNGPITEAALAAVAKFLNYG 98
Query: 134 IINESSKNHVAAYRQTINSLTHCKFEGTEHXXX--------------------------- 166
+I+ SS A ++ H KF G +
Sbjct: 99 LIDASSIKAANAVESIAYAVVHTKFIGGKSTGSDECLFLRNSRKKVNFHKKSTQNLLEMC 158
Query: 167 ----XXXXXXXXXXIESIIASPSGEILSDSCVYDVLQTVMSLACNKRRTDVLRKAAEMSM 222
+ S++ SP G +LS+ V D++Q+ + + + +LRKAAE ++
Sbjct: 159 QNFIRSANLDEFYVLRSLLLSPPGILLSNEAVCDMMQSCFRIVFEQNLSLLLRKAAESTL 218
Query: 223 LSITVKIFDKLKKLDSSKQHIFI 245
+T IF +L +H +I
Sbjct: 219 ADMTQLIFTRLPTFVEDTRHPYI 241
>7303476 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 2040
Score = 202 bits (515), Expect = 2e-51
Identities = 210/804 (26%), Positives = 353/804 (43%), Gaps = 147/804 (18%)
Query: 262 AEGSSDIDSVENGNFTASSESQNLES--DYGLAVIKDYMDILVSLLLPENQHKQNNSTKV 319
A S I+SV FT S ++ S YGL I++ L+ L P + KQN+ + +
Sbjct: 335 ANSSEYINSV-GVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPLD--KQNSDSMM 391
Query: 320 F-GLHLLNTAIELAGDKFPQHPQLFSLVADPICKNILYIIQNSDKLSLLQAALQLFTNLT 378
GL LL A E+A D ++ L LV D +C+N++ ++ +S++LS+ A LQL L
Sbjct: 392 HTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLL-SSERLSIFAADLQLCFLLF 450
Query: 379 IILGDHLSLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLIEQISILWTRSPSFFTAV 438
L HL Q+E + + I+ N P ++EL ++ + LW R P F T +
Sbjct: 451 ESLRGHLKFQLEAYLRKLSEIIASDNPKT-----PYEMRELALDNLLQLW-RIPGFVTEL 504
Query: 439 FINFDCSLERSDLAIEFLMALTKL------------------------------------ 462
+IN+DC L +D+ L+K
Sbjct: 505 YINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIERNCAASKNS 564
Query: 463 -----SLPESALTTSDSVPPICLEGLISVVDDM---------------------HDHFLK 496
SLPE+A T S GL +V D H L+
Sbjct: 565 SNNRESLPEAAPATGGSRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQ 624
Query: 497 AGVQE--FVPEELGTLNKRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSED-EIAK 553
+G + E+L + ++ K + E FN++P+KGI L E G +++ + ++A
Sbjct: 625 SGGEGVGITSEQLAKVKQK--KRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVAL 682
Query: 554 FLFDNNARLNKKTIGEFIAAPEKVG--LLAKFIGMFDFTGLRIDEAIRALLTKFRLPGES 611
FL +N L+KK IGE+I+ + V +L F+ FDFTGLR+D+A+R L FRLPGE+
Sbjct: 683 FLRENPG-LDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEA 741
Query: 612 QQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNP 671
I V+E FS D + +D + D+ F L+Y++I+LN D +N
Sbjct: 742 PLIFLVLEHFS-----DHWHKQNQDPF----------ANVDAAFRLAYAIIMLNMDQHNS 786
Query: 672 QVKK---HMTFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDDS 728
K+ MT ED+T NL+G N +DF L +V+ +I+++EIVMP E G R +
Sbjct: 787 NAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVR-ENYQ 845
Query: 729 WNNLIAATTVVTEAHEVSKCESYVQSLGPNQLIQFDKAIFESVGSSIIETLFKIFEVASD 788
W L+ + H+ YV +D IF V + + L +F+ +++
Sbjct: 846 WKVLLRR----GDTHDGH--FHYVHD------ASYDVEIFNIVWGASLSALSFMFDKSTE 893
Query: 789 DHIATRMLTTLDKCSNLASLFELGDIYNDVITTMAKFTTLTGERKPVDDVYVDEIPVVQI 848
R L K + +++ + L ++ ++ T+ KFTTL + +
Sbjct: 894 TGY-QRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTL----------------LSSV 936
Query: 849 DVEDSKESIAVSNVAILLGNDFKAQLSTVVLFRILRQNTNVALITEVTWNKIIDMLLSLY 908
+ + + + A+ G + KAQ + +F ++ + +W I+D+ L L+
Sbjct: 937 EQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGD---CLRESWKHILDLYLQLF 993
Query: 909 ENMLITPDIFPDLQVRLKLPNLPKCKPEVLI----NRSNSSRGLLSTFASYL--KGDEEP 962
L+ + +++ + + + ++ R GL S+ S++ +G EP
Sbjct: 994 RLKLLPKSL-------IEVEDFCEANGKAMLILEKPREKQESGLFSSLYSFISSEGQREP 1046
Query: 963 TDEEIQASTKAMECIKTANISASL 986
T EE +CIK + L
Sbjct: 1047 TYEEQDFIKLGRKCIKECQLDQML 1070
Score = 85.9 bits (211), Expect = 4e-16
Identities = 47/160 (29%), Positives = 86/160 (53%)
Query: 74 DPLLSGLIQLRLMLNHKDNLEDVDALTVLQPFLLVISTASTSGYITSLALDSLQKFFAFG 133
D LL I L+ LN ++L ++ L PFL VI TA +G +TSLAL S+ K ++G
Sbjct: 39 DSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLEVIRTADATGPLTSLALASVNKLLSYG 98
Query: 134 IINESSKNHVAAYRQTINSLTHCKFEGTEHXXXXXXXXXXXXXIESIIASPSGEILSDSC 193
+I+ +S N + +++TH +F GT+ + ++I SP G +S+
Sbjct: 99 LIDPTSPNLADIVERIADAVTHARFMGTDQSSDGVTFMRVIEVLHTLIRSPEGAAVSNVS 158
Query: 194 VYDVLQTVMSLACNKRRTDVLRKAAEMSMLSITVKIFDKL 233
+ +V+ + ++ R +++LR++AE S+ + + F +L
Sbjct: 159 MCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRL 198
>Hs4758416 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1859
Score = 183 bits (464), Expect = 2e-45
Identities = 139/489 (28%), Positives = 244/489 (49%), Gaps = 76/489 (15%)
Query: 503 VPEELGTLNKRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSED-EIAKFLFDNNAR 561
+P+ + +N K I E+FN+KPKKGI L EKG ++ ++ E+A++L + N R
Sbjct: 687 LPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRE-NPR 745
Query: 562 LNKKTIGEFIAAPEKVGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQF 621
L+KK IGEF++ + + LL F+ F F GLR+DEA+R L FRLPGE+ I+R++E F
Sbjct: 746 LDKKMIGEFVSDRKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAF 805
Query: 622 SAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKH---MT 678
+ +++ + ++D+ F L+Y+VI+LNTD +N V+K MT
Sbjct: 806 TERWMNCN---------------GSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMT 850
Query: 679 FEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDDSWNNLIAATTV 738
E++ NLKG N KDF L+ +Y +I+++EIVMPEE G R + WN L+
Sbjct: 851 LEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVR-ENYVWNVLL----- 904
Query: 739 VTEAHEVSKCESYVQSLGPNQLIQFDKAIFESVGSSIIETLFKIFEVASDDHIATRMLTT 798
H + E + +D +F I L +F+ + ++ I + ++
Sbjct: 905 ----HRGATPEGIFLRV---PTASYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISG 957
Query: 799 LDKCSNLASLFELGDIYNDVITTMAKFTTLTGERKPVDDVYVDEIPVVQIDVEDSKESIA 858
KC+ +++ + L D+++++I ++ KFT L+ E +
Sbjct: 958 FRKCAMISAHYGLSDVFDNLIISLCKFTALSSE--------------------------S 991
Query: 859 VSNVAILLGNDFKAQLSTVVLFRILRQNTNVALITEVTWNKIIDMLLSLYENMLITPDIF 918
+ N+ + G++ KA ++ +F + ++ + I W I++ +L L+ L+
Sbjct: 992 IENLPSVFGSNPKAHIAAKTVFHLAHRHGD---ILREGWKNIMEAMLQLFRAQLL----- 1043
Query: 919 PDLQVRLKLPNLPKCKPEVLINRSNSSRG--LLSTFASY--LKGDEE-----PTDEEIQA 969
P + ++ P K + + S+RG + +F S+ L G E+ P+ E +A
Sbjct: 1044 PKAMIEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEA 1103
Query: 970 STKAMECIK 978
A+ECIK
Sbjct: 1104 KRVALECIK 1112
Score = 89.4 bits (220), Expect = 4e-17
Identities = 67/220 (30%), Positives = 113/220 (50%), Gaps = 15/220 (6%)
Query: 276 FTASSESQNLES-DYGLAVIKDYMDILVSLLLPENQHKQNNSTKV-FGLHLLNTAIELAG 333
FT SS+ + YGL I++ L+SL P ++H N+ + GLHLL A+E A
Sbjct: 385 FTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRH--NSEVMIHMGLHLLTVALESA- 441
Query: 334 DKFPQHPQLFSLVADPICKNILYIIQNSDKLSLLQAALQLFTNLTIILGDHLSLQIEFTI 393
Q L L+ D +C+++ ++ + ++L+L A+L++ L + +HL Q+E I
Sbjct: 442 -PVAQCQTLLGLIKDEMCRHLFQLL-SIERLNLYAASLRVCFLLFESMREHLKFQMEMYI 499
Query: 394 NTIFSILLDSNVSDETKPRPAVVKELLIEQISILWTRSPSFFTAVFINFDCSLERSDLAI 453
+ I ++ E P +KE+ +E I LW R PSF T ++IN+DC S+L
Sbjct: 500 KKLMEI-----ITVENPKMPYEMKEMALEAIVQLW-RIPSFVTELYINYDCDYYCSNLFE 553
Query: 454 EFLMALTKLSLPESALTTSDSVPPICLEGLISVVDDMHDH 493
E L+K + P S + + + L+ L++V+D H
Sbjct: 554 ELTKLLSKNAFPVSGQLYTTHL--LSLDALLTVIDSTEAH 591
Score = 84.0 bits (206), Expect = 2e-15
Identities = 45/175 (25%), Positives = 92/175 (51%), Gaps = 1/175 (0%)
Query: 73 KDPLLSGLIQLRLMLNHKDNLEDVDALTVLQPFLLVISTASTSGYITSLALDSLQKFFAF 132
+DPLL L+ +LN L +++ L+PFL VI + T+G IT LAL S+ KF ++
Sbjct: 36 RDPLLHSFGHLKEVLNSITELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSY 95
Query: 133 GIINESSKNHVAAYRQTINSLTHCKFEGTEHXXXXXXXXXXXXXIESIIASPSGEILSDS 192
+I+ + + +++TH +F GT+ + +++ +P G L++
Sbjct: 96 ALIDPTHEGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNE 155
Query: 193 CVYDVLQTVMSLACNKRRTDVLRKAAEMSMLSITVKIFDKLKKL-DSSKQHIFIN 246
V +++Q+ + R +++LRK+AE +++ + +F +L + + K ++ N
Sbjct: 156 SVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKNYVGTN 210
>Hs5453573 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1785
Score = 147 bits (372), Expect = 9e-35
Identities = 154/634 (24%), Positives = 275/634 (43%), Gaps = 104/634 (16%)
Query: 194 VYDVLQTVMSLACNKRRTDVLRKAAEMSMLSITVKIFDKLKKLDSSKQHIFINDQDFSKN 253
V D+L+ V+ T +++AAE L+ ++ +L+ + + D++ N
Sbjct: 289 VKDILEDVV--------TSAIKEAAEKHGLTEPERVLGELECQECAIPPGV--DENSQTN 338
Query: 254 VLKDDNIGAEGSSDIDSVENGNFTASSESQNLESDYGLAVIKDYMDILVSLLL--PENQH 311
+ DD + +++S G+ A+ S L+ D L V + + + L P +
Sbjct: 339 GIADDRQSLSSADNLESDAQGHQVAARFSHVLQKDAFL-VFRSLCKLSMKPLGEGPPDPK 397
Query: 312 KQNNSTKVFGLHLLNTAIELAGDKFPQHPQLFSLVADPICKNILYIIQN--SDKLSLLQA 369
+KV L LL + ++ AG F H + + +C + + +N S + +
Sbjct: 398 SHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLC---VALSKNGVSSVPDVFEL 454
Query: 370 ALQLFTNLTIILGDHLSLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLIEQISILWT 429
+L +F L HL +QIE IF +L+++ S + ++I+ ++ +
Sbjct: 455 SLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEH------RWMVIQTLTRICA 508
Query: 430 RSPSFFTAVFINFDCSLERSDLAIEFLMALTKLSLPESA----LTTSD--SVPPICLEGL 483
+ +++N+DC L +++ + L+K++ S +T S+ LE L
Sbjct: 509 DAQCVVD-IYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECL 567
Query: 484 ISVVDDMHD----------HFLKAGVQEFVPEELG------------------------- 508
+S++ M + H G + +E+G
Sbjct: 568 VSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQ 627
Query: 509 -TLNKRNLKTEFIKCAEE--------FNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNN 559
T+ + E IK +E FNKKPK+GI L E+G + ++ ED IA+FL
Sbjct: 628 TTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVED-IAQFLHQEE 686
Query: 560 ARLNKKTIGEFIAAPEKVG--LLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERV 617
RL+ +G+F+ + ++ ++ DF A+R L FRLPGE+Q+I+R+
Sbjct: 687 -RLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRL 745
Query: 618 VEQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHM 677
+E+F+A+Y+E T+ AD+ +VL+YS+I+L TD ++PQVK M
Sbjct: 746 MEKFAARYIECNQGQ-------------TLFASADTAYVLAYSIIMLTTDLHSPQVKNKM 792
Query: 678 TFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDDSWNNLIAATT 737
T E Y +G N+ KD P YL +Y I K+I M E L AT
Sbjct: 793 TKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKET------------KELTIATK 840
Query: 738 VVTEAHEVSKCESYVQSLGPNQLIQFDKAIFESV 771
+ K + +L Q+ + KA+ E+V
Sbjct: 841 STKQNVASEKQRRLLYNLEMEQMAKTAKALMEAV 874
>YDR170c [U] KOG0929 Guanine nucleotide exchange factor
Length = 2009
Score = 145 bits (367), Expect = 3e-34
Identities = 111/409 (27%), Positives = 197/409 (48%), Gaps = 57/409 (13%)
Query: 511 NKRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEF 570
N + KT +C FN KPKK IP+LI+KGF+ +S IAK+L + L+ +G++
Sbjct: 823 NLKLRKTALSECIAIFNNKPKKAIPVLIKKGFLKDDSPISIAKWLLETEG-LDMAAVGDY 881
Query: 571 IAAPE--KVGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVED 628
+ + + ++ F+ FDFTG+ I +A+R+ L FRLPGE Q+I+R + +F+ ++V+
Sbjct: 882 LGEGDDKNIAIMHAFVDEFDFTGMSIVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQ 941
Query: 629 QHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKG 688
NP G +S AD+ +VLSYS+I+LNTD ++ Q+K M+ +++ N +G
Sbjct: 942 ---NP--------GVFSK----ADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLENNEG 986
Query: 689 CNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFD-------DSWNNLIAATTVVTE 741
+N +D P +L+ ++ I + EI + E H + D S N + + E
Sbjct: 987 IDNGRDLPRDFLEGLFNEIANNEIKLISEQHQAMLSGDTNLVQQQQSAFNFFNSRDLTRE 1046
Query: 742 AHE------VSKCESYVQSLGPNQ----------LIQFDKAIFESVGSSIIETLFKIFEV 785
A+ SK E ++L N+ ++ K+IFE++ S + L F+
Sbjct: 1047 AYNQVSKEISSKTELVFKNLNKNKGGPDVYYAASHVEHVKSIFETLWMSFLAALTPPFKD 1106
Query: 786 ASDDHIATRMLTTLDKCSNLASLFELGDIYNDVITTMAKFTTLTGERKPVDDVYVDEIPV 845
D + L L +AS F + D + + +F L +
Sbjct: 1107 YDDIDTTNKCLEGLKISIKIASTFRINDARTSFVGALVQFCNLQN--------------L 1152
Query: 846 VQIDVEDSKESIAVSNVAILLGNDFKAQLSTVVLFRILRQNTNVALITE 894
+I V++ + + VA+ GN + ++L ++ Q + LI++
Sbjct: 1153 EEIKVKNVNAMVILLEVALSEGNYLEGSWKDILL--VVSQMERLQLISK 1199
>At1g01960 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1750
Score = 143 bits (360), Expect = 2e-33
Identities = 128/492 (26%), Positives = 222/492 (45%), Gaps = 78/492 (15%)
Query: 302 VSLLLPENQHKQNNSTKVFGLHLLNTAIELAGDKFPQHPQLFSLVADPICKNILYIIQNS 361
+S+ P + + K+ L LL +E AG F + + +C ++L
Sbjct: 350 LSMKTPPKEDPELMRGKIVALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLL-----K 404
Query: 362 DKLSLLQAALQLFTNLTIILGDHLSLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLI 421
+ S L QL ++ + L ++ I F +++ + E +P +++++
Sbjct: 405 NSASNLMIIFQLSCSILLSLVSRFRAGLKAEIGVFFPMIVLRVL--ENVAQPDFQQKMIV 462
Query: 422 EQISILWTRSPSFFTAVFINFDCSLERSDLAIEFLMALTKLSLPESALTTSDSVPPI--- 478
+ +FIN+DC + S++ + L K + T + +PP
Sbjct: 463 LRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGVPPGTVTTLLPPQEAA 522
Query: 479 ----CLEGLISVVDDMHDHFLK---------AGVQEFVPE-------------------- 505
++ L++V+ M D K A + E V
Sbjct: 523 MKLEAMKCLVAVLRSMGDWVNKQLRLPDPYSAKMLEIVDRNLEEGSHPVENGKGDGGHGG 582
Query: 506 --------ELGTLN--------KRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSED 549
EL + N +R K E + FN+KPKKGI LI+ + +S +
Sbjct: 583 FERSDSQSELSSGNSDALAIEQRRAYKLELQEGISIFNQKPKKGIEFLIKANKVG-DSPE 641
Query: 550 EIAKFLFDNNARLNKKTIGEFIAAPEKVGL--LAKFIGMFDFTGLRIDEAIRALLTKFRL 607
EIA FL D + LNK IG+++ E + L + ++ F+F G+ DEAIRA L FRL
Sbjct: 642 EIAAFLKDASG-LNKTLIGDYLGEREDLSLKVMHAYVDSFEFQGMEFDEAIRAFLRGFRL 700
Query: 608 PGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTD 667
PGE+Q+I+R++E+F+ ++ + NP+ D+S+ AD+ +VL+YSVI+LNTD
Sbjct: 701 PGEAQKIDRIMEKFAERFCK---CNPK--------DFSS----ADTAYVLAYSVILLNTD 745
Query: 668 FYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDD 727
+NP VK MT + + N +G ++ KD P YL +Y I EI M ++ G ++
Sbjct: 746 AHNPMVKSKMTADGFIRNNRGIDDGKDLPEEYLRALYERISRNEIKMKDDGLGPQQKQPT 805
Query: 728 SWNNLIAATTVV 739
+ + L+ T++
Sbjct: 806 NSSRLLGLDTIL 817
>At3g60860 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1793
Score = 142 bits (358), Expect = 4e-33
Identities = 120/456 (26%), Positives = 199/456 (43%), Gaps = 75/456 (16%)
Query: 313 QNNSTKVFGLHLLNTAIELAGDKFPQHPQLFSLVADPICKNILYIIQNSDKLSLLQAALQ 372
Q+ K+ L LL +E AG F + + + +C ++L + S L Q
Sbjct: 373 QSMRGKILALELLKILLENAGAVFRTSEKFSADIKQFLCLSLL-----KNSASTLMIIFQ 427
Query: 373 LFTNLTIILGDHLSLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLIEQISILWTRSP 432
L ++ I L ++ I F +++ V E +P +++++ +
Sbjct: 428 LSCSIFISLVARFRAGLKAEIGVFFPMIVLRVV--ENVAQPNFQQKMIVLRFLDKLCLDS 485
Query: 433 SFFTAVFINFDCSLERSDLAIEFLMALTKLSLPESALTTSDSVPPI----------CLEG 482
+F+N+DC + S++ + L K + T + +PP CL
Sbjct: 486 QILVDIFLNYDCDVNSSNIFERMVNGLLKTAQGVPPGTATTLMPPQEAAMKLEAMKCLVA 545
Query: 483 LISVVDDMHDHFLKAGVQEFV--------------------------------------- 503
++ + D + L+ V +
Sbjct: 546 ILKSMGDWLNKQLRLPVSNSLNKSDVIEIDLGPGSPQLANGNADESADGSDTYSESSGGT 605
Query: 504 PEELGTLNKRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLN 563
+ L +R K E + FN+KP KGI LI G + + E EIA FL D + LN
Sbjct: 606 SDALAIEQRRAYKLELQEGISLFNRKPTKGIEFLINAGKVGESPE-EIAGFLKDASG-LN 663
Query: 564 KKTIGEFIAAPEKVGL--LAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQF 621
K IG+++ E + L + ++ FDF G+ DEAIR L FRLPGE+Q+I+R++E+F
Sbjct: 664 KTLIGDYLGEREDLALKVMHAYVDSFDFRGMEFDEAIRTFLEGFRLPGEAQKIDRIMEKF 723
Query: 622 SAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFED 681
+ +Y + NP+ + ADS +VL+YSVI+LNTD +NP VK M+ +D
Sbjct: 724 AERYCK---CNPK------------VFTSADSAYVLAYSVIMLNTDAHNPMVKNKMSADD 768
Query: 682 YTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEE 717
+ N +G ++ KD P Y+ +Y I EI M E+
Sbjct: 769 FIRNNRGIDDGKDLPADYMRSLYERITKHEIKMKED 804
>7298092 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1643
Score = 141 bits (355), Expect = 8e-33
Identities = 169/726 (23%), Positives = 312/726 (42%), Gaps = 119/726 (16%)
Query: 200 TVMSLACNKRRTDVLRKAAEMSMLSITVKIF-----DKLKKLDS-SKQHIFINDQDFSKN 253
++ S CN + LR + E+ + +I + +K +S + +N D+S +
Sbjct: 219 SIHSEDCNGSGEESLRDSDEVIASELLAEIISAAYNEAMKDQESVGEPEPTLNGNDYSSH 278
Query: 254 VLKDDNIGAEGSSDIDSVENGNFTASSESQNLESDYGL---AVIKDYMDILVSLLLPENQ 310
D+ E S+ D+V FT L+ D L A+ K M L
Sbjct: 279 ---SDHDSVELHSENDAVVTAKFT-----HILQKDAFLVFRALCKLSMKPLPDGHPDPKS 330
Query: 311 HKQNNSTKVFGLHLLNTAIELAGDKFPQHPQLFSLVADPICKNILYIIQNSDKLSLL--- 367
H+ + KV LHLL ++ AG F + + +C + +++ +SL+
Sbjct: 331 HELRS--KVLSLHLLLLILQNAGPVFRSNEMFIMAIKQYLC-----VALSNNGVSLVPEV 383
Query: 368 -QAALQLFTNLTIILGDHLSLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLIEQISI 426
+ +L +F L HL QIE IF +L++N S K ++I+ ++
Sbjct: 384 FELSLSIFVALLSNFKVHLKRQIEVFFKEIFLNILEANSSSFEH------KWMVIQALTR 437
Query: 427 LWTRSPSFFTAVFINFDCSLERSDLAIEFLMALTKLSLPESALTTSDS------------ 474
+ + S +++N+DC ++L + L+K++ AL +
Sbjct: 438 ICADAQSVVD-IYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKSMRIRGL 496
Query: 475 ------------------------VPPICLEGLISVVDDMHD-----------HFLKAGV 499
VPP+ ++ S D D H L +
Sbjct: 497 ECLVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQADTTIQTMHSGSSHSLNSN- 555
Query: 500 QEFVPEELGTLNKRNLKTEFIKCAEE-FNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDN 558
QE + + L +R ++ E ++ E FN+KP+KG+ L EK + + D IA++L ++
Sbjct: 556 QEQLQDLPEALEERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCGD-IARWLHED 614
Query: 559 NARLNKKTIGEFIAAPEKVG--LLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIER 616
RL+K IG +I + ++ +I FDF + + A+R LL FRLPGE+Q+I+R
Sbjct: 615 E-RLDKTVIGNYIGENDDHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDR 673
Query: 617 VVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKH 676
++E+F+++Y E NP+ + + AD+V+VL++S+I+L TD ++PQVK
Sbjct: 674 LMEKFASRYCE---CNPK----------NQLFQSADTVYVLAFSIIMLTTDLHSPQVKHK 720
Query: 677 MTFEDYTLNLKGCNNQK-DFPLWYLDKVYCSIRDKEIVMPE--------EHHGSERWFDD 727
MT E Y +G ++ K D P YL +Y I + EI M + G + + +
Sbjct: 721 MTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKNNSGMLQQAKPTGKQAFITE 780
Query: 728 S-----WNNLIAATTVVTEAHEVSKCESYVQS-LGPNQLIQFDKAIFESVGSSIIETLFK 781
WN + + A + + S+V+S + ++ + +F+ + +
Sbjct: 781 KRRKLLWN--MEMEVISLTATNLMQSVSHVKSPFTSAKHLEHVRPMFKMAWTPFLAAFSV 838
Query: 782 IFEVASDDHIATRMLTTLDKCSNLASLFELGDIYNDVITTMAKFTTLTGERKPVDDVYVD 841
+ D IAT L + +A +F + + + +A+FT L P++++
Sbjct: 839 GLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLNA-NSPINEMKAK 897
Query: 842 EIPVVQ 847
I ++
Sbjct: 898 NIDTIK 903
>Hs5453571 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1849
Score = 140 bits (353), Expect = 1e-32
Identities = 160/664 (24%), Positives = 283/664 (42%), Gaps = 130/664 (19%)
Query: 255 LKDDNIGAEGSSDIDSVENGNFTASSE----SQNLESDYGLAVIKDYMDILVSLLL--PE 308
L DD + + D+ E+GN + S S L+ D L V + + + L P
Sbjct: 388 LPDDRLSVSSN---DTQESGNSSGPSPGAKFSHILQKDAFL-VFRSLCKLSMKPLSDGPP 443
Query: 309 NQHKQNNSTKVFGLHLLNTAIELAGDKFPQHPQLFSLVADPICKNILYIIQN--SDKLSL 366
+ +K+ L LL + ++ AG F + + + +C + + +N S +
Sbjct: 444 DPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLC---VALSKNGVSSVPEV 500
Query: 367 LQAALQLFTNLTIILGDHLSLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLIEQISI 426
+ +L +F L HL +QIE IF +L+++ S K ++I+ ++
Sbjct: 501 FELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTSSFDH------KWMVIQTLTR 554
Query: 427 LWTRSPSFFTAVFINFDCSLERSDLAIEFLMALTKLSLPESA--LTTSD----SVPPICL 480
+ + S +++N+DC L +++ + L+K++ + L S+ S+ L
Sbjct: 555 ICADAQSVVD-IYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGL 613
Query: 481 EGLISV----VDDMHDHFLKAGVQEFVPEE------------------LGTLNKRNLKT- 517
E L+S+ V+ D ++ Q + +E G+LN +
Sbjct: 614 ECLVSISKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSS 673
Query: 518 -------------------EFIKCAEE--------FNKKPKKGIPLLIEKGFISSNSEDE 550
E +K +E FNKKPK+GI L E+G + + ED
Sbjct: 674 SGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPED- 732
Query: 551 IAKFLFDNNARLNKKTIGEFIAAPEKVG--LLAKFIGMFDFTGLRIDEAIRALLTKFRLP 608
IA+FL RL+ +GEF+ +K ++ ++ DF+G A+R L FRLP
Sbjct: 733 IAQFLHQEE-RLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLP 791
Query: 609 GESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDF 668
GE+Q+I+R++E+F+A+Y+E T+ AD+ +VL+YS+I+L TD
Sbjct: 792 GEAQKIDRLMEKFAARYLECNQGQ-------------TLFASADTAYVLAYSIIMLTTDL 838
Query: 669 YNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDDS 728
++PQVK MT E Y +G N+ KD P YL +Y I K+I M E
Sbjct: 839 HSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKET----------- 887
Query: 729 WNNLIAATTVVTEAHEVSKCESYVQSLGPNQLIQFDKAIFESV--------GSSIIETLF 780
L T + K + +L Q+ + KA+ E+V ++ +E +
Sbjct: 888 -KELTIPTKSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVR 946
Query: 781 KIFEVA---------------SDDHIATRMLTTLDKCSNLASLFELGDIYNDVITTMAKF 825
+F++A D +A+ L + +A +F + + + +A+F
Sbjct: 947 PMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARF 1006
Query: 826 TTLT 829
T LT
Sbjct: 1007 TLLT 1010
>At4g38200 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1698
Score = 130 bits (328), Expect = 1e-29
Identities = 152/619 (24%), Positives = 255/619 (40%), Gaps = 112/619 (18%)
Query: 318 KVFGLHLLNTAIELAGDKFPQHPQLFSLVADPICKNI--------LYIIQNS--DKLSLL 367
K L LL I+ G + + +L IC+ + L +++NS +S+
Sbjct: 304 KTLSLELLKVIIDNGGPIWLSDERQLTLPPQKICRFLNAIKQLLCLSLLKNSALSVMSIF 363
Query: 368 QAALQLFTNLTIILGDHLSLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLIEQISIL 427
Q +FT L + ++ + +L++ + +P+ V+++ + +
Sbjct: 364 QLQCAIFTTLLRKYRSGMKSEVGIFFPMLVLRVLENVL------QPSFVQKMTVLSLLEN 417
Query: 428 WTRSPSFFTAVFINFDCSLERSDLAIEFLMALTKLSL--PESALTTSDSVPPI------- 478
P+ +F+NFDC +E ++ + L K +L P + T V I
Sbjct: 418 ICHDPNLIIDIFVNFDCDVESPNIFERIVNGLLKTALGPPPGSSTILSPVQDITFRHESV 477
Query: 479 -CLEGLISVVDDMHDHFLKAG-------VQEFVP--------EELGTL------------ 510
CL +I + D L G ++ P EE GT
Sbjct: 478 KCLVSIIKAMGTWMDQQLSVGDSLLPKSLENEAPANNHSNSNEEDGTTIDHDFHPDLNPE 537
Query: 511 --------NKRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARL 562
+R K E K FN+KP KGI LI + NS DE+ FL N L
Sbjct: 538 SSDAATLEQRRAYKIERQKGVTLFNRKPSKGIEFLISSKKV-GNSPDEVVSFL-RNTTGL 595
Query: 563 NKKTIGEFIAAPE--KVGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQ 620
N IG+++ E + ++ ++ FDF + EAIR L FRLPGE+Q+I+R++E+
Sbjct: 596 NATMIGDYLGEREDFPMKVMHAYVDSFDFKEMNFGEAIRFFLRGFRLPGEAQKIDRIMEK 655
Query: 621 FSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFE 680
F+ ++ + NP +S+ AD+ +VL+YSVI+LNTD +N VK+ MT
Sbjct: 656 FAERFCK---CNP--------NSFSS----ADTAYVLAYSVIMLNTDAHNIMVKEKMTKA 700
Query: 681 DYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDDSWNNLIAATTVVT 740
D+ N +G ++ KD P YL +Y + EI M + E + N L+ ++
Sbjct: 701 DFIRNNRGIDDGKDLPEEYLGALYDQVVINEIKMSSDSSAPESRQSNGLNKLLGLDGILN 760
Query: 741 EAHEVSKCESYVQSLGPNQLIQFDKAIFESVGSSIIETLFKIFEVA-------------- 786
+ E V + G LI+ + F S + +VA
Sbjct: 761 LVYWTQTEEKAVGANG--LLIKDIQEKFRSKSGKSESAYHVVTDVAILRFMVEVSWGPML 818
Query: 787 ---------SDDHI-ATRMLTTLDKCSNLASLFELGDIYNDVITTMAKFTTL--TGERKP 834
SDD + A L ++ ++ + + +T+MAKFT L G+ K
Sbjct: 819 AAFSVTLDQSDDRLAAVECLRGFRYAVHVTAVMGMQTQRDAFVTSMAKFTNLHCAGDMKQ 878
Query: 835 VDDVYVDEI-PVVQIDVED 852
+ VD + ++ I +ED
Sbjct: 879 KN---VDAVKAIISIAIED 894
>At4g35380 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1711
Score = 130 bits (326), Expect = 2e-29
Identities = 215/892 (24%), Positives = 370/892 (41%), Gaps = 184/892 (20%)
Query: 97 DALTVLQPFLLVISTASTSGYITSLALDSLQKFFAFGIIN---ESSKNHVAAYRQTINSL 153
DA +VLQPFLL + TA + + +LD K F+ I+ +SSK ++ +N++
Sbjct: 68 DADSVLQPFLLSLETAYSK--VVEPSLDCAFKLFSLSILRGEIQSSKQDSILFK-LVNAV 124
Query: 154 THCKFEGTEHXXXXXXXXXXXXXIESIIASPSGEILSDSCVYDVLQTVMSLACN--KRRT 211
+ E + + + SP I D C+ V++T ++ T
Sbjct: 125 SKVGAIAEEPIQLAVLRV-----LLAAVRSPCILIRGD-CLLHVVKTCYNIYLGGLSGTT 178
Query: 212 DVLRKAAEMSMLSITVKIFDKLKK--LDSSKQHIFIND------------------QDFS 251
+ K+ M+ + IF + ++ LD S + I++N+ Q F
Sbjct: 179 QICAKSVLAQMMLV---IFTRSEEDSLDVSVKTIYVNELLTFTDKSVNEGSSVYFCQGFV 235
Query: 252 KNVLKD----------------DNIGAEGSSDIDSVENGNFTASSESQNLESDYGLAVIK 295
V+ N E DS + A+ E + D V +
Sbjct: 236 NEVMAAGQGSPLPPPDVIQILLQNPETETVMTPDSPSFRGYVANGEGDSETGDMS-KVRQ 294
Query: 296 DYMDILVSL--LLPENQHKQNNST------KVFGLHLLNTAIELAGDKFPQHPQLFSLVA 347
D + +L L K+NN K L LL I+ G + + + V
Sbjct: 295 DAFLLFKNLCKLSMRFSSKENNDDQIMVRGKTLSLELLKVIIDNGGSVWRTNESFINAVK 354
Query: 348 DPICKNILYIIQNS--DKLSLLQAALQLFTNLTIILGDHLSLQIEFTINTIFSILLDSNV 405
+C L +++NS +S+ Q +F +L L L +I I +L++ +
Sbjct: 355 QYLC---LSLLKNSAVSIMSIFQLQCAIFMSLLSKLRSVLKAEIGIFFPMIVLRVLENVL 411
Query: 406 SDETKPRPAVVKELLIEQISILWTRSPSFFTAVFINFDCSLERSDLAIEFLMALTKLSL- 464
+P+ ++++ + + ++ P +F+N+DC +E S++ + L K +L
Sbjct: 412 ------QPSYLQKMTVLNLLDKMSQDPQLMVDIFVNYDCDVESSNILERIVNGLLKTALG 465
Query: 465 -PESALTT----------SDSVPPICLEGLISVVDDMHDHFLKA-------GVQEF---- 502
P + TT +DSV CL L + + D LK G Q +
Sbjct: 466 PPTGSSTTLSPAQDSTFRNDSVK--CLVNLAKAMGNWMDQQLKVNETVWPKGSQVYASMD 523
Query: 503 -----VPEELGTLN-------------------------KRNLKTEFI-KCAEEFNKKPK 531
+ E GT++ K L+ +++ K FN+KP
Sbjct: 524 SNASQISELEGTISDCDSQPDTSNPEAYDASMLEQRRAYKIELQVQYLQKGISLFNRKPS 583
Query: 532 KGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVGL--LAKFIGMFDF 589
KG+ LI I S+ E E+A FL A LN IG+++ +++ L + ++ F+F
Sbjct: 584 KGVEFLISTKKIGSSPE-EVASFLM-KTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNF 641
Query: 590 TGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQP 649
EAIR L FRLPGE+Q+I+R++E+F+ Y + NP G +++
Sbjct: 642 EKKDFVEAIRFFLRGFRLPGEAQKIDRIMEKFAEHYWK---CNP--------GSFTS--- 687
Query: 650 DADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRD 709
AD+ +VL+YSVI+LNTD +N VK MT D+ N +G ++ KD P YL +Y +
Sbjct: 688 -ADTAYVLAYSVIMLNTDAHNNMVKDKMTKADFVRNNRGIDDGKDLPEEYLGSLYDRVVK 746
Query: 710 KEIVMPEEHHGSERWFDDSWNNLIAATTVVTEAHEVSKCESYVQSLGPN-QLIQFDKAIF 768
+EI M + + + N L+ ++ + VS + + G N +LI+ + F
Sbjct: 747 EEIRMNSDTLAPQNKQVNGLNKLLGLDGIL---NLVSWMQPDEKPHGANGRLIRDIQEQF 803
Query: 769 -------ESVGSSI--IETLFKIFEVA--------------SDDHIATRM-LTTLDKCSN 804
ESV ++ I L I EV+ SDD +AT + L +
Sbjct: 804 QAKPEKSESVYHTVTDISILRFILEVSWGPMLAAFSVTIDQSDDRLATSLCLQGFRYAVH 863
Query: 805 LASLFELGDIYNDVITTMAKFTTL----TGERKPVDDVYVDEIPVVQIDVED 852
+ ++ + + +T+MAKFT L ++K VD V ++ I +ED
Sbjct: 864 VTAVMGMQTQRDAFVTSMAKFTNLHCAADMKQKNVDAVKA----IITIAIED 911
>SPAC30.01c [U] KOG0929 Guanine nucleotide exchange factor
Length = 1822
Score = 129 bits (324), Expect = 3e-29
Identities = 94/337 (27%), Positives = 165/337 (48%), Gaps = 46/337 (13%)
Query: 522 CAEEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEK--VGL 579
C +FN KP +G+ +L E ++ N IA+FLF + ++K T+G+++ ++ + +
Sbjct: 715 CINKFNYKPTRGLKMLSENEYVDINDPKAIAEFLFRADG-IDKTTLGDYLGEGDEKSISV 773
Query: 580 LAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLE 639
+ +FI F L+ +A+R LL FRLPGE+Q+I+R++ +FS +Y+++ NP
Sbjct: 774 MHEFIDCLSFINLKFVDALRRLLQCFRLPGEAQKIDRIMLKFSERYMKE---NPSAFA-- 828
Query: 640 IEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWY 699
+AD+ ++L+YS+I+LNTD ++P++K MT ED+ N +G N+ D Y
Sbjct: 829 ----------NADTAYILAYSIILLNTDLHSPRIKNKMTKEDFIKNNRGINDGADLDEDY 878
Query: 700 LDKVYCSIRDKEIVMPEE-----------HHGSERWFDDSWNN---------LIAATTVV 739
L VY I EI M ++ + + F +N + A+ +
Sbjct: 879 LGFVYDDILKNEIAMKDDQELAAIAPLMNNFSTSSGFTTFTSNGRDLQRVACIQASEEMA 938
Query: 740 TEAHEVSKCESYVQSLGPNQL-IQFDKAIFESVGSSIIETLFKIFEVASDDHIATRMLTT 798
+A V K Y Q G + + ++ FE +G + T I S+ + +
Sbjct: 939 NKATSVLKKLLYQQKHGSQKTNVYYNATHFEHIGPMLEATWMPILAALSNPLQNSDYVNE 998
Query: 799 LDKCSN-------LASLFELGDIYNDVITTMAKFTTL 828
L+ C + +A LF+L I + I T+ FT L
Sbjct: 999 LNMCLDGFQLVVRIACLFDLDLIRDAFIKTLTNFTNL 1035
>SPAC4D7.01c [U] KOG0929 Guanine nucleotide exchange factor
Length = 1811
Score = 128 bits (322), Expect = 6e-29
Identities = 69/209 (33%), Positives = 121/209 (57%), Gaps = 18/209 (8%)
Query: 511 NKRNLKTEFIKCAEEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEF 570
N ++ K + + ++FN KPK+GI +L+ FI+S + +IAKFL L+K +GE+
Sbjct: 695 NLKHRKKQLQEAIQKFNYKPKEGIKILLSSHFIASKTPTDIAKFLISTEG-LDKAVLGEY 753
Query: 571 IAA--PEKVGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVED 628
+ E + ++ F+ F + A+R+ L KFRLPGE+Q+I+R + +F+ KY++D
Sbjct: 754 LGEGNDENIAIMHSFVDHMSFNDIPFVNALRSFLQKFRLPGEAQKIDRFMLKFAEKYIDD 813
Query: 629 QHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKG 688
+ +AD+ ++L+YS+I+LNTD ++PQVK MT +D+ N +G
Sbjct: 814 N---------------LGVFKNADTAYILAYSIIMLNTDLHSPQVKNRMTCQDFIKNNRG 858
Query: 689 CNNQKDFPLWYLDKVYCSIRDKEIVMPEE 717
++ + +L +VY I+ EIV+ +E
Sbjct: 859 VDDGANLSDSFLTEVYEEIQKNEIVLKDE 887
>CE24576 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1628
Score = 126 bits (316), Expect = 3e-28
Identities = 150/669 (22%), Positives = 291/669 (43%), Gaps = 93/669 (13%)
Query: 96 VDALTVLQPFLLVISTASTSGYITSLALDSLQKFFAFGIINESSKNHVAAYRQTINSLTH 155
V+A PF L ++ S IT ALD LQK A+G + + R+ I+ +
Sbjct: 74 VEADRYFLPFELACNSKSPKIVIT--ALDCLQKLIAYGHLTGRGADISNPERKLIDRIVE 131
Query: 156 CKF-----EGTEHXXXXXXXXXXXXXIESIIASPSGEILSDSCVYDVLQTVMSLACNKRR 210
+GT+ + +++ S E+ S + V +T ++ +
Sbjct: 132 AICAPFLGQGTDETVLLQLIKA----VLAVVLSTHCEVHGASLILAV-RTCFNIYLTSK- 185
Query: 211 TDVLRKAAEMSMLSITVKIFDKLKKLDSSKQHIFINDQDFSKNVLKDDNIGAEGSSDIDS 270
+ + + A+ ++ + +F ++K + K I + VL + I E S +
Sbjct: 186 SPINQATAKGTLTQVINTVFGNMEKFGNIKDDETIVREVVE--VLVSNTISNEVSDETSE 243
Query: 271 V-----ENGNFTASSESQNLESDYGL--AVIKDYMDILVSLLLPENQHKQNNS------T 317
+NG+ SE+ L+ + A KD + +L + + + S +
Sbjct: 244 AGGTHRQNGSTMGESEAP-LDDQFTFMNAYQKDAFLVFRALCILAQKEEGGASNEMSLRS 302
Query: 318 KVFGLHLLNTAIELAGDKFPQHPQLFSLVADPICKNILYIIQN--SDKLSLLQAALQLFT 375
K+ L +L ++ + ++ +C + + +N S+ + + + +L +F
Sbjct: 303 KLLALEMLLLVLQNSSSILQSSQPCIIVIKRTLC---MALTRNAVSNNIQVFEKSLAIFV 359
Query: 376 NLTIILGDHLSLQIEFTINTIFSILLDSNVSDETKPRPAVVKELLIEQISILWTRSPSFF 435
L HL IE N++ +LDSN + K +++ I + +P
Sbjct: 360 ELLDKFKTHLKASIEVFFNSVILPMLDSNTCAFEQ------KWIVLNTIGKILA-NPQSV 412
Query: 436 TAVFINFDCSLERSDLAIEFLMALTKLSLPESALTTSDSVPPI--------------CLE 481
+F+N+DC + +L + ++K + T +++ PP CL
Sbjct: 413 VDMFVNYDCDMTSPNLFKSIVEVVSKTT----RTTINENAPPAQKEKERAMRLLGLSCLT 468
Query: 482 GLISVVDDMHD----HFLKAGVQEFVPEE---------LGTLNK-RNLKTEFIKCAEEFN 527
L+ + D + + + + P E TL + +NL + I+ F+
Sbjct: 469 DLLQCLVDWWQVCEVQKITSDIDDAEPSEQQHGETFEAFETLKQQKNLMEQGIQI---FS 525
Query: 528 KKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVG--LLAKFIG 585
+KPKKG+ L E GF+ +++ E+A+F+ RLNK +G+F+ ++ ++ +I
Sbjct: 526 EKPKKGLKFLQEHGFVGTDAV-EVAEFMMKEE-RLNKTQVGDFLGDSDEFNNSVMHAYID 583
Query: 586 MFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYS 645
DF+ + I A+R L KFRLPGE+Q+I+R++ +F+++Y++ NP +
Sbjct: 584 FLDFSSIDILAALRMFLEKFRLPGEAQKIDRLMLKFASRYLD---CNPRQG--------- 631
Query: 646 TIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLDKVYC 705
I AD+ +VL++S+I+L TD +N VK MT + Y +G N + P+ L+ ++
Sbjct: 632 -IFASADAAYVLAFSIIMLTTDLHNKTVKNKMTKQGYINMNRGINEGGNIPVELLEAIFE 690
Query: 706 SIRDKEIVM 714
I EI M
Sbjct: 691 DISKNEIKM 699
>7302131 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 348
Score = 113 bits (282), Expect = 2e-24
Identities = 66/196 (33%), Positives = 109/196 (54%), Gaps = 19/196 (9%)
Query: 524 EEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVG--LLA 581
++FN PKKGI L+E + + +D +A FL+ LNK IG+++ +L
Sbjct: 24 KKFNMDPKKGIEYLVENRLLRHDPQD-VAHFLYKGEG-LNKTAIGDYLGEKNDFNEDVLK 81
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
F+ + DFT L + +A+R L FRLPGE+Q+I+R++E F+ +Y + NP+
Sbjct: 82 AFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQ---LNPD------- 131
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
I + D+ +VLS+++I+LNT +NP VK T + + +G NN D P L+
Sbjct: 132 -----IFTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLE 186
Query: 702 KVYCSIRDKEIVMPEE 717
+Y SIR + +P++
Sbjct: 187 SLYESIRTEPFKIPQD 202
>Hs7662290 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 841
Score = 112 bits (279), Expect = 5e-24
Identities = 69/204 (33%), Positives = 111/204 (53%), Gaps = 31/204 (15%)
Query: 526 FNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKV---GLLAK 582
FNKKP+KG+ LIE+GF+ +A FL L+++ IGEF+ +K +L
Sbjct: 413 FNKKPEKGVQYLIERGFVPDTPVG-VAHFLLQRKG-LSRQMIGEFLGNRQKQFNRDVLDC 470
Query: 583 FIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKY------VEDQHYNPERD 636
+ DF+ + +DEA+R R+ GE+Q++ER++E FS +Y V Q NP
Sbjct: 471 VVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNP--- 527
Query: 637 GLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVK--KHMTFEDYTLNLKGCNNQKD 694
D++F+L++++I+LNTD Y+P VK + M ED+ NL+G ++ +D
Sbjct: 528 ---------------DTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGED 572
Query: 695 FPLWYLDKVYCSIRDKEIVMPEEH 718
P L +Y IR +E+ E+H
Sbjct: 573 IPREMLMGIYERIRKRELKTNEDH 596
>Hs8670546 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 400
Score = 111 bits (278), Expect = 7e-24
Identities = 68/196 (34%), Positives = 109/196 (54%), Gaps = 19/196 (9%)
Query: 524 EEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVGL--LA 581
++FN PKKGI L+E + N+ +EIA+FL+ LNK IG+++ E++ L L
Sbjct: 70 KKFNMDPKKGIQFLVENELLQ-NTPEEIARFLYKGEG-LNKTAIGDYLGEREELNLAVLH 127
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
F+ + +FT L + +A+R L FRLPGE+Q+I+R++E F+ +Y NP
Sbjct: 128 AFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCL---CNPG------- 177
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
+ D+ +VLS++VI+LNT +NP V+ E + +G N D P L
Sbjct: 178 -----VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLR 232
Query: 702 KVYCSIRDKEIVMPEE 717
+Y SIR++ +PE+
Sbjct: 233 NLYDSIRNEPFKIPED 248
>Hs4758966 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 399
Score = 111 bits (278), Expect = 7e-24
Identities = 68/196 (34%), Positives = 109/196 (54%), Gaps = 19/196 (9%)
Query: 524 EEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVGL--LA 581
++FN PKKGI L+E + N+ +EIA+FL+ LNK IG+++ E++ L L
Sbjct: 70 KKFNMDPKKGIQFLVENELLQ-NTPEEIARFLYKGEG-LNKTAIGDYLGEREELNLAVLH 127
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
F+ + +FT L + +A+R L FRLPGE+Q+I+R++E F+ +Y NP
Sbjct: 128 AFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCL---CNPG------- 177
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
+ D+ +VLS++VI+LNT +NP V+ E + +G N D P L
Sbjct: 178 -----VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLR 232
Query: 702 KVYCSIRDKEIVMPEE 717
+Y SIR++ +PE+
Sbjct: 233 NLYDSIRNEPFKIPED 248
>Hs8670544 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 397
Score = 111 bits (277), Expect = 9e-24
Identities = 65/196 (33%), Positives = 110/196 (55%), Gaps = 19/196 (9%)
Query: 524 EEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEK--VGLLA 581
++FN PKKGI LIE + + ED IA+FL+ LNK IG+++ ++ + +L
Sbjct: 71 KKFNMDPKKGIQFLIENDLLKNTCED-IAQFLYKGEG-LNKTAIGDYLGERDEFNIQVLH 128
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
F+ + +FT L + +A+R L FRLPGE+Q+I+R++E F+ +Y + +
Sbjct: 129 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNN----------- 177
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
+ D+ +VLS+++I+LNT +NP VK T E + +G N+ D P L
Sbjct: 178 ----GVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLR 233
Query: 702 KVYCSIRDKEIVMPEE 717
+Y SI+++ +PE+
Sbjct: 234 NLYESIKNEPFKIPED 249
>Hs4758964 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 398
Score = 111 bits (277), Expect = 9e-24
Identities = 65/196 (33%), Positives = 110/196 (55%), Gaps = 19/196 (9%)
Query: 524 EEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEK--VGLLA 581
++FN PKKGI LIE + + ED IA+FL+ LNK IG+++ ++ + +L
Sbjct: 71 KKFNMDPKKGIQFLIENDLLKNTCED-IAQFLYKGEG-LNKTAIGDYLGERDEFNIQVLH 128
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
F+ + +FT L + +A+R L FRLPGE+Q+I+R++E F+ +Y + +
Sbjct: 129 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNN----------- 177
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
+ D+ +VLS+++I+LNT +NP VK T E + +G N+ D P L
Sbjct: 178 ----GVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLR 233
Query: 702 KVYCSIRDKEIVMPEE 717
+Y SI+++ +PE+
Sbjct: 234 NLYESIKNEPFKIPED 249
>Hs14764245 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 1488
Score = 109 bits (273), Expect = 3e-23
Identities = 66/204 (32%), Positives = 114/204 (55%), Gaps = 31/204 (15%)
Query: 526 FNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKV---GLLAK 582
FNKKP+KGI LIE+GF+S +A F+ + L+++ IGEF+ +K +L
Sbjct: 764 FNKKPEKGIQYLIERGFLSDTPVG-VAHFILERKG-LSRQMIGEFLGNRQKQFNRDVLDC 821
Query: 583 FIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKY------VEDQHYNPERD 636
+ DF+ + +D+A+R + R+ GE+Q++ER++E FS +Y + Q NP
Sbjct: 822 VVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNP--- 878
Query: 637 GLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVK--KHMTFEDYTLNLKGCNNQKD 694
D++F+L++++I+LNTD Y+P VK + M +D+ NL+G +N +D
Sbjct: 879 ---------------DTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGED 923
Query: 695 FPLWYLDKVYCSIRDKEIVMPEEH 718
P L +Y I+ +E+ ++H
Sbjct: 924 IPRDLLVGIYQRIQGRELRTNDDH 947
>Hs14767357 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 701
Score = 106 bits (265), Expect = 2e-22
Identities = 98/347 (28%), Positives = 162/347 (46%), Gaps = 43/347 (12%)
Query: 526 FNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKV---GLLAK 582
FN P KGI LI +GFI ++ +A FL L+++ IGEF+ +K +L
Sbjct: 181 FNINPDKGIQFLISRGFIP-DTPIGVAHFLLQRKG-LSRQMIGEFLGNSKKQFNRDVLDC 238
Query: 583 FIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKY------VEDQHYNPERD 636
+ DF+ + +DEA+R R+ GE+Q++ER++E FS +Y V Q +NP
Sbjct: 239 VVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNP--- 295
Query: 637 GLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVK--KHMTFEDYTLNLKGCNNQKD 694
D++F+L++++I+LNTD Y+P +K + M ED+ NL+G ++ D
Sbjct: 296 ---------------DTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGAD 340
Query: 695 FPLWYLDKVYCSIRDKEIVMPEEHHGSERWFDDSWNNLIAATTVVTEAHEVSKCESYVQS 754
P + +Y I+ KE+ E+H + +++ TV++ H C S +
Sbjct: 341 IPRELVVGIYERIQQKELKSNEDH---VTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFE 397
Query: 755 LGPNQLIQFDKAIFESVGSSIIETLFKIFEVASDDHIATRMLTTLDKCSNLASLFEL--G 812
+ +Q A V + L I ++ ++ T L F+L
Sbjct: 398 VTDVNKLQKQAAHQREV--FLFNDLLVILKLCPKKK-SSSTYTFCKSVGLLGMQFQLFEN 454
Query: 813 DIYNDVITTMAKFTTLTG-ERKPVDDVYVDEIPVVQIDVEDSKESIA 858
+ Y+ IT + T L+G E+K V +Q VED KESIA
Sbjct: 455 EYYSHGITLV---TPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIA 498
>Hs4758968 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 399
Score = 105 bits (261), Expect = 7e-22
Identities = 64/196 (32%), Positives = 109/196 (54%), Gaps = 19/196 (9%)
Query: 524 EEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEK--VGLLA 581
++FN PKKGI LIE + S+ ED +A+FL+ LNK IG+++ ++ + +L
Sbjct: 75 KKFNMDPKKGIQFLIENDLLQSSPED-VAQFLYKGEG-LNKTVIGDYLGERDEFNIKVLQ 132
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
F+ + +F L + +A+R L FRLPGE+Q+I+R++E F+++Y NP
Sbjct: 133 AFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYC---LCNP-------- 181
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
+ D+ +VLS+++I+LNT +N V+ T E + +G N D P L
Sbjct: 182 ----GVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLR 237
Query: 702 KVYCSIRDKEIVMPEE 717
+Y SI+++ +PE+
Sbjct: 238 NLYESIKNEPFKIPED 253
>7296387 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 1210
Score = 104 bits (260), Expect = 9e-22
Identities = 64/198 (32%), Positives = 108/198 (54%), Gaps = 19/198 (9%)
Query: 526 FNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEK---VGLLAK 582
FNKKP+KGI LI +GF+ N+ +A+FL L+++ IGE++ + + +L+
Sbjct: 662 FNKKPEKGITYLIRRGFLE-NTPQGVARFLITRKG-LSRQMIGEYLGNLQNQFNMAVLSC 719
Query: 583 FIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEG 642
F D +G ++D A+R FR+PGE+Q+IER++E FS +Y E
Sbjct: 720 FAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRY------------CECNA 767
Query: 643 DYSTIQPDADSVFVLSYSVIILNTDFYNPQVK--KHMTFEDYTLNLKGCNNQKDFPLWYL 700
D +D++FVL++++I+LNTD + P +K + M ED+ NL+G ++ D L
Sbjct: 768 DIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDML 827
Query: 701 DKVYCSIRDKEIVMPEEH 718
+Y ++ E +H
Sbjct: 828 MGIYDRVKSDEFKPGSDH 845
>Hs7019505 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 394
Score = 104 bits (259), Expect = 1e-21
Identities = 72/240 (30%), Positives = 119/240 (49%), Gaps = 23/240 (9%)
Query: 480 LEGLISVVDDMHDHFLKAGVQEFVPEELGTLNKRNLKTEFIKCAEEFNKKPKKGIPLLIE 539
LE + + D++ D F + E E ++ L ++FN P KGI IE
Sbjct: 30 LEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCIG----RKKFNMDPAKGIQYFIE 85
Query: 540 KGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVGL--LAKFIGMFDFTGLRIDEA 597
++ + +D IA+FL+ LNK IG ++ + + L L F+ +F L + +A
Sbjct: 86 HKLLTPDVQD-IARFLYKGEG-LNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQA 143
Query: 598 IRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVL 657
+R L FRLPGE+Q+I+R++E F+ +Y NP + D+ +VL
Sbjct: 144 LRQFLWSFRLPGEAQKIDRMMEAFATRYCL---CNPG------------VFQSTDTCYVL 188
Query: 658 SYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEE 717
S+S+I+LNT +NP V+ FE + +G NN D P L ++ SI+ + +PE+
Sbjct: 189 SFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPED 248
>CE12328 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 614
Score = 99.4 bits (246), Expect = 4e-20
Identities = 64/199 (32%), Positives = 108/199 (54%), Gaps = 22/199 (11%)
Query: 529 KPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIA---APEKVGLLAKFIG 585
KP++G+ LL GF+ NS D +A LF L+K IGE+I +P +L F
Sbjct: 212 KPERGVQLLTAWGFVK-NSPDSLASLLFGRRG-LSKSMIGEYIGTLHSPYHSLVLKYFTA 269
Query: 586 MFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYS 645
+ D GL +D A+R + F LP E+++I+R+++ F+ Y + NP+R S
Sbjct: 270 LIDIRGLEVDVALRKAMQFFILPKEAEKIDRIIQAFALHYSKS---NPKRT--------S 318
Query: 646 TIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCN------NQKDFPLWY 699
+ D++ +LS+++I+LNTD ++P VK+ MT D+ NL+G + N +D
Sbjct: 319 HYRGGWDTIHLLSFAIIMLNTDLHSPNVKQRMTQADFVKNLRGQDKISGEKNGEDIDRKT 378
Query: 700 LDKVYCSIRDKEIVMPEEH 718
L+ +Y I+ E+ ++H
Sbjct: 379 LEGIYDRIKKDELKAGDDH 397
>ECU10g1140 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1063
Score = 80.1 bits (196), Expect = 2e-14
Identities = 51/161 (31%), Positives = 77/161 (47%), Gaps = 6/161 (3%)
Query: 565 KTIGEFIAAPEKVGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAK 624
K +G F+ + L F G FDF + I + +R L F L E Q I RVVE ++ K
Sbjct: 340 KKLGGFLCKLKNEDYLRIFTGTFDFLDMDILDGLRTYLLSFHLSAEGQIIHRVVEAYADK 399
Query: 625 YVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTL 684
Y D ++I D T + VF L++S ++LNT F+NP VK TF DY
Sbjct: 400 YYSDNV--DACTFMDITRDKRT----KEFVFNLAFSFLVLNTKFHNPNVKAKPTFRDYMK 453
Query: 685 NLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEEHHGSERWF 725
+ F YL+ +Y S++ + + P ++H S +
Sbjct: 454 DFTAEEIPPSFSEEYLESMYQSVKKRPLEFPAKNHPSREHY 494
>Hs4506161 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 645
Score = 75.1 bits (183), Expect = 7e-13
Identities = 43/131 (32%), Positives = 72/131 (54%), Gaps = 15/131 (11%)
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
+++ F FTG+ +D+A+R L + L GE+Q+ ERV+ FS +Y + NPE E
Sbjct: 214 EYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQ---CNPEALSSE-- 268
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
D L+ ++++LNTD + + K MT D+ NL+G N+ DFP L
Sbjct: 269 ----------DGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLK 318
Query: 702 KVYCSIRDKEI 712
+Y SI+++++
Sbjct: 319 ALYSSIKNEKL 329
>Hs6912706 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 1056
Score = 73.9 bits (180), Expect = 2e-12
Identities = 41/131 (31%), Positives = 70/131 (53%), Gaps = 15/131 (11%)
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
+++ F F G +D A+R+ L L GE+Q+ ER++ QFS ++ H NP
Sbjct: 623 EYLSFFQFGGQSLDRALRSFLQALVLSGETQERERILYQFSRRF---HHCNPG------- 672
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
I P DSV L+ ++++LNTD + + K M+ +++ NL G + +FP L
Sbjct: 673 -----IFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRDGGNFPKELLK 727
Query: 702 KVYCSIRDKEI 712
+Y SIR +++
Sbjct: 728 ALYWSIRSEKL 738
>Hs22064762 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 113
Score = 72.4 bits (176), Expect = 5e-12
Identities = 39/98 (39%), Positives = 63/98 (63%), Gaps = 4/98 (4%)
Query: 524 EEFNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEK--VGLLA 581
++FN PKKGI LIE + + ED IA+FL+ LNK IG+++ ++ + +L
Sbjct: 12 KKFNMDPKKGIQFLIENDLLKNTCED-IAQFLYKGEG-LNKTAIGDYLGERDEFNIQVLH 69
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVE 619
F+ + +FT L + +A+R L FRLPGE+Q+I+R++E
Sbjct: 70 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMME 107
>Hs14150035 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 771
Score = 70.1 bits (170), Expect = 2e-11
Identities = 40/131 (30%), Positives = 71/131 (53%), Gaps = 15/131 (11%)
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
+++ FDF+GL +D A+R L F L GE+Q+ ERV+ FS +Y + NP+ E
Sbjct: 349 EYLSFFDFSGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQ---CNPDDSTSE-- 403
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
D + L+ ++++LNTD + + K M+ + + NL N+ +DF L
Sbjct: 404 ----------DGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLK 453
Query: 702 KVYCSIRDKEI 712
+Y SI+++++
Sbjct: 454 TLYNSIKNEKL 464
>Hs7662396 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 534
Score = 67.8 bits (164), Expect = 1e-10
Identities = 51/174 (29%), Positives = 91/174 (51%), Gaps = 21/174 (12%)
Query: 544 SSNSE--DEIAKFLFDNNARLNKKTIGEFIAAPEKVGLLA--KFIGMFDFTGLRIDEAIR 599
SSN E +AK L+ + R + + + + + L +++ FDFTG+ +D+++R
Sbjct: 65 SSNVEAAKRLAKRLYQLD-RFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLR 123
Query: 600 ALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSY 659
F L GE+Q+ ERV+ FS +Y + NP+ TI D V L+
Sbjct: 124 YFFKAFSLVGETQERERVLIHFSNRYF---YCNPD-----------TI-ASQDGVHCLTC 168
Query: 660 SVIILNTDFY-NPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEI 712
++++LNTD + + + K MT +++ NL+G N DF L +Y SI+++++
Sbjct: 169 AIMLLNTDLHGHVNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKL 222
>CE29066 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 818
Score = 67.0 bits (162), Expect = 2e-10
Identities = 47/154 (30%), Positives = 78/154 (50%), Gaps = 28/154 (18%)
Query: 561 RLNKKTIGEFIAAPEKVGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQ 620
RLN++ F+ +L K++ +F F+ RID A+R L++ L GES ER++
Sbjct: 407 RLNEQNEFSFL-------ILVKYLELFQFSTTRIDAALREFLSRVELRGESSARERLLRV 459
Query: 621 FSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFE 680
FSA+Y+E NP I D V L+ ++++LN+D + P + K MT
Sbjct: 460 FSARYLE---CNP------------AIFDSLDEVHTLTCALLLLNSDLHGPNMGKKMTAR 504
Query: 681 DYTLNL--KGCNNQKDFPLWYLDKVYCSIRDKEI 712
D+ N+ GC +++ L ++ SI+D I
Sbjct: 505 DFITNIAHTGCTFKREM----LKTLFQSIKDNAI 534
>CE19234 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 816
Score = 67.0 bits (162), Expect = 2e-10
Identities = 47/154 (30%), Positives = 78/154 (50%), Gaps = 28/154 (18%)
Query: 561 RLNKKTIGEFIAAPEKVGLLAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQ 620
RLN++ F+ +L K++ +F F+ RID A+R L++ L GES ER++
Sbjct: 405 RLNEQNEFSFL-------ILVKYLELFQFSTTRIDAALREFLSRVELRGESSARERLLRV 457
Query: 621 FSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFE 680
FSA+Y+E NP I D V L+ ++++LN+D + P + K MT
Sbjct: 458 FSARYLE---CNP------------AIFDSLDEVHTLTCALLLLNSDLHGPNMGKKMTAR 502
Query: 681 DYTLNL--KGCNNQKDFPLWYLDKVYCSIRDKEI 712
D+ N+ GC +++ L ++ SI+D I
Sbjct: 503 DFITNIAHTGCTFKREM----LKTLFQSIKDNAI 532
>CE26942 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 393
Score = 63.9 bits (154), Expect = 2e-09
Identities = 61/230 (26%), Positives = 106/230 (45%), Gaps = 26/230 (11%)
Query: 495 LKAGVQEFVPEELGTLNKRNLKTE-----FIKCAEEFNKKPKKGIPLLIEKGFISSNSED 549
LK V+E V EEL + + K++ + ++FN+ P K + L + ++ + +
Sbjct: 36 LKNEVRE-VDEELDQVYYTHPKSKEYHKIVVNGRKKFNQDPWKALDWLASRNVVAKDPQ- 93
Query: 550 EIAKFLFDNNARLNKKTIGEFIA--APEKVGLLAKFIGMFDFTGLRIDEAIRALLTKFRL 607
+A ++ L+K IGE + P + L +F + I A+R L FRL
Sbjct: 94 ALALWMKAGEG-LSKSAIGEILGDNRPFALETLDRFTKEHKLHDVPIVPALRQYLFSFRL 152
Query: 608 PGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYSTIQPDADSVFVLSYSVIILNTD 667
PGESQ+I R++E+F+ Y + NP +AD ++YS I++NT
Sbjct: 153 PGESQKINRILEKFAEVYA---NQNPS-------------YGNADQAHTVAYSCIMVNTL 196
Query: 668 FYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLDKVYCSIRDKEIVMPEE 717
+NP VK + E Y + + + L +VY S+ + +P+E
Sbjct: 197 LHNPNVKDKPSLEKYIEMNEQLLEKGAITIEQLTEVYESVSVTQFKIPDE 246
>YPR095c [U] KOG0929 Guanine nucleotide exchange factor
Length = 1226
Score = 63.2 bits (152), Expect = 3e-09
Identities = 38/127 (29%), Positives = 68/127 (52%), Gaps = 8/127 (6%)
Query: 587 FDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDYST 646
F+F +D A+R LL LP E+QQI+R++ FS Y + Q ++ G+E
Sbjct: 501 FEFKNDPLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKKGIECPWS--- 557
Query: 647 IQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYT--LNLKGCNNQKDFPLWYLDKVY 704
+AD V+ +++S+++L+TD++NP K MT D+ ++ + + P+ L Y
Sbjct: 558 ---NADQVYFIAFSLLMLHTDYFNPNNKSKMTKHDFVDLVHNDKYSGGNEIPMAVLTYFY 614
Query: 705 CSIRDKE 711
++ KE
Sbjct: 615 ENVTAKE 621
>SPAC26F1.01 [U] KOG0929 Guanine nucleotide exchange factor
Length = 657
Score = 61.2 bits (147), Expect = 1e-08
Identities = 33/106 (31%), Positives = 60/106 (56%), Gaps = 15/106 (14%)
Query: 580 LAKFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLE 639
L K++ + +F + +D A+R L + LP E+QQI+RV+ FS +Y H NP+
Sbjct: 38 LRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYF---HCNPD----- 89
Query: 640 IEGDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLN 685
+ +D ++L++S++IL+TDF+N ++ MT ++ N
Sbjct: 90 -------LYDSSDECYILTFSLMILHTDFFNIHNRQKMTRAEFISN 128
>7300886 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 900
Score = 61.2 bits (147), Expect = 1e-08
Identities = 36/131 (27%), Positives = 72/131 (54%), Gaps = 15/131 (11%)
Query: 582 KFIGMFDFTGLRIDEAIRALLTKFRLPGESQQIERVVEQFSAKYVEDQHYNPERDGLEIE 641
+++ F F +D+A+R L +F L GE+Q+ ERV+ FS ++++ NP
Sbjct: 460 EYLKHFTFEKKSLDQALREFLQQFSLSGETQERERVLVHFSKRFLD---CNP-------- 508
Query: 642 GDYSTIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGCNNQKDFPLWYLD 701
G +++ D+V L+ ++++LNTD + + + M+ ++ NL N+ ++FP L
Sbjct: 509 GTFNS----QDAVHTLTCAIMLLNTDLHGQNINRKMSCAEFVDNLADLNDGENFPKDVLK 564
Query: 702 KVYCSIRDKEI 712
+Y +I+ K +
Sbjct: 565 SLYQAIKTKPL 575
>Hs15812208 [U] KOG0929 Guanine nucleotide exchange factor
Length = 319
Score = 56.6 bits (135), Expect = 3e-07
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 18/182 (9%)
Query: 526 FNKKPKKGIPLLIEKGFISSNSEDEIAKFLFDNNARLNKKTIGEFIAAPEKVGLLAKFIG 585
FN P +G+ + KG + +S EIAKF+F LN K + ++ E+ +L +
Sbjct: 146 FNANPDEGVNYFMSKGILD-DSPKEIAKFIFCTRT-LNWKKLRIYL--DERRDVLDDLVT 201
Query: 586 MFDFTGLRIDEAIRALLTKFRLPGE-SQQIERVVEQFSAKYVEDQHYNPERDGLEIEGDY 644
+ +F + A+R P E + +E ++ +FS ++ NP D + G
Sbjct: 202 LHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCA---CNP--DLMRELG-- 254
Query: 645 STIQPDADSVFVLSYSVIILNTDFYNPQVKKHMTFEDYTLNLKGC--NNQKDFPLWYLDK 702
+ PDA V+VL YS+I+L+ D +P VK M+ ++ N + N +DF D
Sbjct: 255 --LSPDA--VYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDN 310
Query: 703 VY 704
+Y
Sbjct: 311 IY 312
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.134 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,800,773
Number of Sequences: 60738
Number of extensions: 3067775
Number of successful extensions: 8905
Number of sequences better than 1.0e-05: 45
Number of HSP's better than 0.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 8709
Number of HSP's gapped (non-prelim): 91
length of query: 1387
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1268
effective length of database: 23,161,394
effective search space: 29368647592
effective search space used: 29368647592
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)