ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV6056 check: MH C KOG4773 Energy production and conversion NADPH oxidase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV6056 Similar to YBR200w SP|P29366 BEM1 bud emergence
mediator singleton
(569 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBR200w [C] KOG4773 NADPH oxidase 539 e-153
SPAC22H10.07 [C] KOG4773 NADPH oxidase 224 2e-58
7303765 [T] KOG4225 Sorbin and SH3 domain-containing protein 54 5e-07
Hs4885235 [T] KOG0197 Tyrosine kinases 53 1e-06
Hs4885661 [T] KOG0197 Tyrosine kinases 52 2e-06
CE29645 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH... 51 5e-06
CE29644 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH... 51 5e-06
Hs4504357 [T] KOG0197 Tyrosine kinases 50 1e-05
Hs13653487 [T] KOG0197 Tyrosine kinases 50 1e-05
Hs4503823 [T] KOG0197 Tyrosine kinases 49 2e-05
CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin 49 2e-05
7294071 [Z] KOG1702 Nebulin repeat protein 49 2e-05
Hs4505573 [F] KOG2070 Guanine nucleotide exchange factor 49 3e-05
Hs22027528 [F] KOG2070 Guanine nucleotide exchange factor 49 3e-05
Hs4557785 [C] KOG4773 NADPH oxidase 48 3e-05
Hs22046240 [C] KOG4773 NADPH oxidase 48 3e-05
CE01784 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 48 5e-05
Hs5730001 [D] KOG0515 p53-interacting protein 53BP/ASPP contains... 47 6e-05
Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein 47 6e-05
Hs22046608 [C] KOG4773 NADPH oxidase 47 6e-05
Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein 47 6e-05
Hs5729856 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 47 1e-04
Hs4504111 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 46 1e-04
7294461 [Z] KOG3655 Drebrins and related actin binding proteins 46 1e-04
Hs4758794 [Z] KOG1702 Nebulin repeat protein 45 2e-04
Hs4505055 [T] KOG0197 Tyrosine kinases 45 4e-04
Hs5453758 [Z] KOG1702 Nebulin repeat protein 44 5e-04
7296156 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH... 44 5e-04
7300664_2 [TUZ] KOG2856 Adaptor protein PACSIN 44 5e-04
Hs20541236 [C] KOG4773 NADPH oxidase 44 7e-04
SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding prot... 44 9e-04
SPAC20G8.05c [D] KOG2398 Predicted proline-serine-threonine phos... 44 9e-04
Hs20533984 [T] KOG4225 Sorbin and SH3 domain-containing protein 44 9e-04
CE27551 [T] KOG0197 Tyrosine kinases 44 9e-04
7292519 [T] KOG0197 Tyrosine kinases 44 9e-04
YFR024c-a [S] KOG1843 Uncharacterized conserved protein 43 0.001
YFR024c [S] KOG1843 Uncharacterized conserved protein 43 0.001
YDR388w [U] KOG3771 Amphiphysin 43 0.001
HsM8923232 [T] KOG3557 Epidermal growth factor receptor kinase s... 43 0.001
Hs21264608 [T] KOG3557 Epidermal growth factor receptor kinase s... 43 0.001
Hs21264606 [T] KOG3557 Epidermal growth factor receptor kinase s... 43 0.001
Hs8400706 [T] KOG4792 Crk family adapters 43 0.001
Hs7662208 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-acti... 43 0.001
Hs22065489 [T] KOG4792 Crk family adapters 43 0.001
Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin 43 0.001
Hs20149528 [D] KOG2398 Predicted proline-serine-threonine phosph... 43 0.001
YHR016c [S] KOG1843 Uncharacterized conserved protein 42 0.002
Hs5453754 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and ... 42 0.002
Hs4885609 [T] KOG0197 Tyrosine kinases 42 0.002
Hs20533142 [O] KOG2177 Predicted E3 ubiquitin ligase 42 0.002
Hs4885153 [T] KOG4792 Crk family adapters 42 0.002
Hs4506929 [IT] KOG1118 Lysophosphatidic acid acyltransferase end... 42 0.002
Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein 42 0.002
Hs20428652 [T] KOG0197 Tyrosine kinases 42 0.002
CE24991 [T] KOG0197 Tyrosine kinases 42 0.002
Hs8400708 [T] KOG4792 Crk family adapters 42 0.003
Hs4505347 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and ... 42 0.003
Hs18699720 [D] KOG0515 p53-interacting protein 53BP/ASPP contain... 42 0.003
Hs18552166 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and... 42 0.003
CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endop... 42 0.003
Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin 42 0.003
SPBC21D10.12 [U] KOG3771 Amphiphysin 41 0.004
Hs4557377 [T] KOG0197 Tyrosine kinases 41 0.004
Hs20550422 [F] KOG2070 Guanine nucleotide exchange factor 41 0.004
Hs16418431 [R] KOG4429 Uncharacterized conserved protein contain... 41 0.004
7302199 [T] KOG0197 Tyrosine kinases 41 0.004
7298751 [TU] KOG1029 Endocytic adaptor protein intersectin 41 0.004
Hs5453710 [Z] KOG1702 Nebulin repeat protein 41 0.006
Hs4758296 [T] KOG3557 Epidermal growth factor receptor kinase su... 41 0.006
Hs19923335 [T] KOG4225 Sorbin and SH3 domain-containing protein 40 0.007
CE28290 [U] KOG3875 Peroxisomal biogenesis protein peroxin 40 0.007
YGR136w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 40 0.009
HsM12232453 [T] KOG3557 Epidermal growth factor receptor kinase ... 40 0.009
Hs4505871 [I] KOG1264 Phospholipase C 40 0.009
Hs21264616 [T] KOG3557 Epidermal growth factor receptor kinase s... 40 0.009
Hs18598741 [I] KOG1264 Phospholipase C 40 0.009
Hs4506931 [IT] KOG1118 Lysophosphatidic acid acyltransferase end... 40 0.012
Hs19224660 [TUZ] KOG2856 Adaptor protein PACSIN 40 0.012
7301982 [T] KOG4348 Adaptor protein CMS/SETA 40 0.012
Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin 40 0.012
Hs4826844 [Z] KOG0162 Myosin class I heavy chain 39 0.016
Hs4503355 [T] KOG1998 Signaling protein DOCK180 39 0.016
CE00538 [T] KOG4225 Sorbin and SH3 domain-containing protein 39 0.016
7303308 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 39 0.016
Hs5174647 [T] KOG0197 Tyrosine kinases 39 0.021
Hs20070146 [IT] KOG1118 Lysophosphatidic acid acyltransferase en... 39 0.021
7294985 [Z] KOG3565 Cdc42-interacting protein CIP4 39 0.028
Hs6005826 [TUZ] KOG2856 Adaptor protein PACSIN 38 0.036
Hs20546302 [O] KOG2177 Predicted E3 ubiquitin ligase 38 0.036
Hs4507191 [Z] KOG0040 Ca2+-binding actin-bundling protein (spect... 38 0.047
Hs4502413 [T] KOG0197 Tyrosine kinases 38 0.047
Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 38 0.047
Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4 38 0.047
7299844 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 38 0.047
SPBC1734.08 [T] KOG2199 Signal transducing adaptor protein STAM/... 37 0.062
Hs9507221 [G] KOG3734 Predicted phosphoglycerate mutase 37 0.062
Hs7661700 [T] KOG4225 Sorbin and SH3 domain-containing protein 37 0.062
Hs5454056 [T] KOG4225 Sorbin and SH3 domain-containing protein 37 0.062
Hs4758476 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 37 0.062
YCR088w [Z] KOG3655 Drebrins and related actin binding proteins 37 0.080
SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH... 37 0.080
Hs14777594 [TZ] KOG3632 Peripheral benzodiazepine receptor PRAX-1 37 0.080
Hs14777578 [TZ] KOG3632 Peripheral benzodiazepine receptor PRAX-1 37 0.080
CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 37 0.080
7291268 [D] KOG0515 p53-interacting protein 53BP/ASPP contains a... 37 0.080
Hs4885643 [D] KOG0515 p53-interacting protein 53BP/ASPP contains... 37 0.10
CE16651 [T] KOG4225 Sorbin and SH3 domain-containing protein 37 0.10
7298672 [F] KOG2070 Guanine nucleotide exchange factor 37 0.10
7290878 [TZ] KOG4035 Coeffector of mDia Rho GTPase regulates act... 37 0.10
SPBC12C2.05c [Z] KOG3565 Cdc42-interacting protein CIP4 36 0.14
Hs4506071 [T] KOG0695 Serine/threonine protein kinase 36 0.14
CE28360 [T] KOG4792 Crk family adapters 36 0.14
HsM7661718 [Z] KOG3655 Drebrins and related actin binding proteins 36 0.18
Hs4502249 [T] KOG0521 Putative GTPase activating proteins (GAPs) 36 0.18
Hs21361670 [Z] KOG3655 Drebrins and related actin binding proteins 36 0.18
SPCC1223.04c [R] KOG1337 N-methyltransferase 35 0.23
Hs4505723 [U] KOG3875 Peroxisomal biogenesis protein peroxin 35 0.23
Hs22051526 [Z] KOG0162 Myosin class I heavy chain 35 0.23
Hs20555436 [TUZ] KOG2856 Adaptor protein PACSIN 35 0.23
CE19084 [S] KOG2995 FOG: SH3 domain 35 0.23
CE18868 [Z] KOG3655 Drebrins and related actin binding proteins 35 0.23
YHR114w [Z] KOG3565 Cdc42-interacting protein CIP4 35 0.31
YHL002w [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 35 0.31
Hs7661670 [S] KOG1843 Uncharacterized conserved protein 35 0.31
Hs4885633 [T] KOG3523 Putative guanine nucleotide exchange facto... 35 0.31
CE29545 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 35 0.31
7292157 [Z] KOG0040 Ca2+-binding actin-bundling protein (spectri... 35 0.31
SPBC11C11.02 [D] KOG2398 Predicted proline-serine-threonine phos... 35 0.40
SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein 35 0.40
Hs22046517 [T] KOG3523 Putative guanine nucleotide exchange fact... 35 0.40
Hs20545357 [T] KOG0583 Serine/threonine protein kinase 35 0.40
Hs16418371 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related pro... 35 0.40
CE07373 [Z] KOG0040 Ca2+-binding actin-bundling protein (spectri... 35 0.40
7303429 [U] KOG3771 Amphiphysin 35 0.40
CE18886_2 [F] KOG2070 Guanine nucleotide exchange factor 35 0.40
SPBC19C2.10 [IT] KOG1118 Lysophosphatidic acid acyltransferase e... 34 0.52
Hs22047742 [T] KOG0521 Putative GTPase activating proteins (GAPs) 34 0.52
Hs22040999 [Z] KOG3565 Cdc42-interacting protein CIP4 34 0.52
Hs20546502 [T] KOG1998 Signaling protein DOCK180 34 0.52
7302755_2 [S] KOG2995 FOG: SH3 domain 34 0.52
YPR154w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 34 0.68
Hs4885611 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 34 0.68
Hs21361641 [R] KOG0266 WD40 repeat-containing protein 34 0.68
CE19874 [D] KOG0515 p53-interacting protein 53BP/ASPP contains a... 34 0.68
7297777 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 34 0.68
Hs4557787 [T] KOG4225 Sorbin and SH3 domain-containing protein 33 0.89
Hs4507189 [Z] KOG0040 Ca2+-binding actin-bundling protein (spect... 33 0.89
Hs21071018 [T] KOG3557 Epidermal growth factor receptor kinase s... 33 0.89
Hs21071016 [T] KOG3557 Epidermal growth factor receptor kinase s... 33 0.89
Hs21071014 [T] KOG3557 Epidermal growth factor receptor kinase s... 33 0.89
Hs15451926 [T] KOG0905 Phosphoinositide 3-kinase 33 0.89
SPCC1919.11 [IT] KOG1118 Lysophosphatidic acid acyltransferase e... 33 1.2
SPBC146.13c [Z] KOG0162 Myosin class I heavy chain 33 1.2
Hs4507429 [T] KOG0197 Tyrosine kinases 33 1.2
7294076 [T] KOG4278 Protein tyrosine kinase 33 1.2
Hs4505869 [I] KOG1264 Phospholipase C 33 1.5
Hs16158568 [T] KOG4637 Adaptor for phosphoinositide 3-kinase 33 1.5
CE25256 [TZ] KOG3632 Peripheral benzodiazepine receptor PRAX-1 33 1.5
CE22093 [T] KOG0197 Tyrosine kinases 33 1.5
Hs7382493 [C] KOG4773 NADPH oxidase 32 2.0
Hs4885433 [T] KOG3775 Mitogen-activated protein kinase scaffold ... 32 2.0
CE03428 [U] KOG3771 Amphiphysin 32 2.0
Hs7662296 [Z] KOG3565 Cdc42-interacting protein CIP4 32 2.6
Hs4506431 [R] KOG3508 GTPase-activating protein 32 2.6
Hs4505345 [C] KOG4773 NADPH oxidase 32 2.6
Hs16163690 [Z] KOG3565 Cdc42-interacting protein CIP4 32 2.6
Hs12545406 [R] KOG3508 GTPase-activating protein 32 2.6
CE21930 [T] KOG4348 Adaptor protein CMS/SETA 32 2.6
7293213 [I] KOG1264 Phospholipase C 32 2.6
Hs7706706 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related prot... 32 3.4
CE28644 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activa... 32 3.4
7300449 [IT] KOG1118 Lysophosphatidic acid acyltransferase endop... 32 3.4
Hs17474837_1 [Z] KOG1654 Microtubule-associated anchor protein i... 32 3.4
Hs11968152_1 [R] KOG0504 FOG: Ankyrin repeat 32 3.4
YLR191w [U] KOG3875 Peroxisomal biogenesis protein peroxin 31 4.4
Hs7705981 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 31 4.4
Hs4503787 [T] KOG0197 Tyrosine kinases 31 4.4
Hs11968025 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 31 4.4
CE14974 [T] KOG3557 Epidermal growth factor receptor kinase subs... 31 4.4
CE05763 [Z] KOG0162 Myosin class I heavy chain 31 4.4
7293174 [R] KOG3508 GTPase-activating protein 31 4.4
YMR109w [Z] KOG0162 Myosin class I heavy chain 31 5.8
YDL117w [D] KOG4575 TGc (transglutaminase/protease-like) domain-... 31 5.8
HsM14149706 [T] KOG3523 Putative guanine nucleotide exchange fac... 31 5.8
Hs21361487 [T] KOG3523 Putative guanine nucleotide exchange fact... 31 5.8
Hs20559073 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 31 5.8
Hs18765725 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 31 5.8
Hs17447529 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and... 31 5.8
Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA 31 5.8
CE27042 [R] KOG2030 Predicted RNA-binding protein 31 5.8
YKL129c [Z] KOG0162 Myosin class I heavy chain 30 7.5
Hs7706537 [T] KOG3775 Mitogen-activated protein kinase scaffold ... 30 7.5
Hs6912492 [T] KOG3775 Mitogen-activated protein kinase scaffold ... 30 7.5
Hs21237775 [T] KOG3775 Mitogen-activated protein kinase scaffold... 30 7.5
Hs19424130 [O] KOG1366 Alpha-macroglobulin 30 7.5
Hs11342676 [Z] KOG3565 Cdc42-interacting protein CIP4 30 7.5
YMR012w [R] KOG1839 Uncharacterized protein CLU1/cluA/TIF31 invo... 30 9.8
Hs4758956 [TZ] KOG3632 Peripheral benzodiazepine receptor PRAX-1 30 9.8
Hs20535816 [T] KOG0695 Serine/threonine protein kinase 30 9.8
Hs15718680 [T] KOG0197 Tyrosine kinases 30 9.8
Hs10864650 [T] KOG0695 Serine/threonine protein kinase 30 9.8
CE14976 [T] KOG3557 Epidermal growth factor receptor kinase subs... 30 9.8
CE14972 [T] KOG3557 Epidermal growth factor receptor kinase subs... 30 9.8
7290607 [A] KOG2253 U1 snRNP complex subunit SNU71 and related P... 30 9.8
>YBR200w [C] KOG4773 NADPH oxidase
Length = 551
Score = 539 bits (1389), Expect = e-153
Identities = 309/594 (52%), Positives = 375/594 (63%), Gaps = 79/594 (13%)
Query: 2 KKDS--VKQRITSADISGPTQSPGSSVQNVKTIPIRXXXXXXXXXXXXXXXX------XK 53
K+DS K RITSADIS P+ GS ++++KT+P+R K
Sbjct: 9 KRDSNGSKGRITSADISTPSHDNGSVIKHIKTVPVRYLSSSSTPVKSQRDSSPKNRHNSK 68
Query: 54 DISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
DI+SPEKVIKA Y+YQAQ++ ELSF +G+FF+V +E DWY+ASNP+ GK G+VPK YFE
Sbjct: 69 DITSPEKVIKAKYSYQAQTSKELSFMEGEFFYVSGDEKDWYKASNPSTGKEGVVPKTYFE 128
Query: 114 IFGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQA 173
+F RT+P+S NGS S+ NMG+LYAIVLYDF+A
Sbjct: 129 VFDRTKPSSV---------NGSNSSSRKVTNDSL-----------NMGSLYAIVLYDFKA 168
Query: 174 EKADELTAYAGENLFICAHHDFEWFIAKPIGRXXXXXXXXXXFVTIIDIATGYATGNDVK 233
EKADELT Y GENLFICAHH+ EWFIAKPIGR FV+IIDIATGYATGNDV
Sbjct: 169 EKADELTTYVGENLFICAHHNCEWFIAKPIGRLGGPGLVPVGFVSIIDIATGYATGNDVI 228
Query: 234 SDIESVNLPSVQEWKINIARYKASNITLGSVEQQGQSYVQHXXXXXXXXXXXXPHPSTQH 293
DI+SVNLP+VQEWK NIARYKASNI+LGSVEQQ Q + Q+
Sbjct: 229 EDIKSVNLPTVQEWKSNIARYKASNISLGSVEQQQQQSIT----------------KPQN 272
Query: 294 SSAANTTYPADAVFLTYAAVETFFLQDDKYWFQVSCQLSNNTTRILKRYYEDFYDLQVKL 353
SA D L A+VE+F L+D+KYWF V C+LSN TR LKRYY+DFYDLQV+L
Sbjct: 273 KSAKLV----DGELLVKASVESFGLEDEKYWFLVCCELSNGKTRQLKRYYQDFYDLQVQL 328
Query: 354 LDIFPAEGGKLRDTNGQWTKRIMPYIPGPVPYVTDTISKKRKDDLNIYVKDLISLPPHIS 413
LD FPAE GKLRD GQW+KRIMPYIPGPVPYVT++I+KKRK+DLNIYV DL++LP +IS
Sbjct: 329 LDAFPAEAGKLRDAGGQWSKRIMPYIPGPVPYVTNSITKKRKEDLNIYVADLVNLPDYIS 388
Query: 414 QSHLVKGLFAVKNNGFDREISNDET-------VELDVKGRA------------DDSTLTN 454
+S +V LF V NNGFDRE DE E D A D+TLT
Sbjct: 389 RSEMVHSLFVVLNNGFDREFERDENQNNIKTLQENDTATFATASQTSNFASTNQDNTLTG 448
Query: 455 QELQLPEAMKRLSLIXXXXXXXXKVKSRPPSGFAPRITDEKPVKIKFYYKDDIFALMLHP 514
++L+L + + LSL + ++ SG K KIKFYYKDDIFALML
Sbjct: 449 EDLKLNKKLSDLSL-----SGSKQAPAQSTSGL-------KTTKIKFYYKDDIFALMLKG 496
Query: 515 TITFEELCSKIAPRIDADSFKLYIKNGDDIGTQVTTDAEVPVLIQEKRKIFVDD 568
T++EL SKIAPRID D+FKL K D G ++ TD++V +IQ K KI V D
Sbjct: 497 DTTYKELRSKIAPRIDTDNFKLQTKLFDGSGEEIKTDSQVSNIIQAKLKISVHD 550
>SPAC22H10.07 [C] KOG4773 NADPH oxidase
Length = 536
Score = 224 bits (572), Expect = 2e-58
Identities = 168/550 (30%), Positives = 253/550 (45%), Gaps = 78/550 (14%)
Query: 55 ISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND--WYEASNPADGKRGMVPKNYF 112
I P KVI+ALY+Y A+ A E+SF KGDFFHV END WYE NPA G RG VP ++F
Sbjct: 22 IEPPRKVIRALYDYTARKATEVSFAKGDFFHVIGRENDKAWYEVCNPAAGTRGFVPVSHF 81
Query: 113 EIFGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGT--LYAIVLYD 170
E G+T VKS + G + G+ L+ IV +D
Sbjct: 82 EEIGKT--------VKSERDSDGSGQISFTDLTTNSSTTRSSISELHSGSQPLFGIVQFD 133
Query: 171 FQAEKADELTAYAGENLFICAHHDFEWFIAKPIGRXXXXXXXXXXFVTIIDIATGYATGN 230
F AE+ DEL A AGE + I A + EW +AKPIGR F+ + D+ TG A
Sbjct: 134 FAAERPDELEAKAGEAIIIIARSNHEWLVAKPIGRLGGPGLIPLSFIQLRDLKTG-AVIK 192
Query: 231 DVKSDIESVN-LPSVQEWKINIARYKASNITLG--------SVEQQGQSYVQHXXXXXXX 281
DV + ++ +P V++WK A YK S+I LG ++ S
Sbjct: 193 DVSEAVLRISCIPRVEDWKRAAADYKKSSIPLGKFSDGETQTMPSLSPSTENLQINNDVT 252
Query: 282 XXXXXPHPSTQHSSAANTTYPADAV-------------------FLTYAAVETFFLQDDK 322
+ ST S AN P + + A VE + ++DD+
Sbjct: 253 YQAATDNSSTFPGSVANELTPLQTLESRTASIASKNKKDMSSEPTVVAAMVENYMIRDDQ 312
Query: 323 YWFQVSCQLSNNTTRILKRYYEDFYDLQVKLLDIFPAEGGKLRDTNGQWTKRIMPYIPGP 382
YW+ V +S+ R L RYYEDF++ Q K L++FP E G+ + +R++PY+PGP
Sbjct: 313 YWYLVRAVMSDGKHRNLCRYYEDFFNFQTKFLELFPNEAGRGDE------RRVIPYMPGP 366
Query: 383 VPYVTDTISKKRKDDLNIYVKDLISLPPHISQSHLVKGLFAVKNNGFDREISNDETVELD 442
V V + IS +R DL++Y+K++ LP + ++ LVK LF + +G D
Sbjct: 367 VDDVNELISSQRAMDLDVYLKEMCRLPARLLENELVK-LFFLPLDG-------------D 412
Query: 443 VKGRADDSTLTNQELQLPEAMKRLSLIXXXXXXXXKVKSRPPSGFAPRITDEKPVKIKFY 502
V+ ST +PEA+ R L + + + T K+K
Sbjct: 413 VESPHPTST-------MPEALPREPLSFSLPEKAPEKATNISIPESAPTTAGSTCKVKVR 465
Query: 503 YKDDIFALMLHPTITFEELCSKIAPRI---------DADSFK-LYIKNGDDIGTQVTTDA 552
D+ FAL + I+FE+ C ++ ++ D ++ K L + N DD+ + ++
Sbjct: 466 LGDETFALRVPSDISFEDFCERLTNKLGECEHLSYRDTNANKVLPLNNVDDLRKACSQES 525
Query: 553 EVPVLIQEKR 562
V + + +R
Sbjct: 526 GVLLFAERRR 535
>7303765 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 500
Score = 54.3 bits (129), Expect = 5e-07
Identities = 41/154 (26%), Positives = 68/154 (43%), Gaps = 36/154 (23%)
Query: 53 KDISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNY 111
K + P+ V +AL+N+Q Q++ ELSF KGD +++++ + +WYE + A G++P +Y
Sbjct: 239 KSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNA--MIGLLPASY 296
Query: 112 FEIFGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDF 171
EI R ++ ++ S G A Y+F
Sbjct: 297 VEIVSR-------DGARTPSKRPSEGQ--------------------------ARAKYNF 323
Query: 172 QAEKADELTAYAGENLFICAHHDFEWFIAKPIGR 205
QA+ EL+ GE + + D WF K R
Sbjct: 324 QAQSGIELSLNKGELVTLTRRVDGNWFEGKIANR 357
Score = 43.1 bits (100), Expect = 0.001
Identities = 37/165 (22%), Positives = 66/165 (39%), Gaps = 30/165 (18%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEIF------ 115
+A YN+QAQS ELS NKG+ + ++ + +W+E ++G+ P +Y E+
Sbjct: 318 RAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGK--IANRKGIFPCSYVEVLTDIGAE 375
Query: 116 ---GRT------------RPNSHA------SPVKSINRNGSVGSNXXXXXXXXXXXXXXX 154
RT RPN + ++ +NG+ N
Sbjct: 376 DIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDAL 435
Query: 155 XXPSNMGTLYAIVLYDFQAEKADELTAYAGENLFICAHHDFEWFI 199
++ L LY ++ + +DEL G+ + + D WF+
Sbjct: 436 HVDTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFV 480
Score = 41.6 bits (96), Expect = 0.003
Identities = 22/61 (36%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 54 DISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYF 112
D SS +ALY Y+ Q++ EL +GD HV ++ +D W+ ++ G G P NY
Sbjct: 438 DTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYV 497
Query: 113 E 113
E
Sbjct: 498 E 498
>Hs4885235 [T] KOG0197 Tyrosine kinases
Length = 529
Score = 52.8 bits (125), Expect = 1e-06
Identities = 22/49 (44%), Positives = 34/49 (68%), Gaps = 1/49 (2%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNY 111
ALY+Y+A++ +L+F KG+ FH+ E DW+EA + + GK G +P NY
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNY 132
Score = 33.1 bits (74), Expect = 1.2
Identities = 15/46 (32%), Positives = 25/46 (53%)
Query: 158 SNMGTLYAIVLYDFQAEKADELTAYAGENLFICAHHDFEWFIAKPI 203
S +G I LYD++A D+LT GE I + + +W+ A+ +
Sbjct: 75 SGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120
>Hs4885661 [T] KOG0197 Tyrosine kinases
Length = 543
Score = 52.4 bits (124), Expect = 2e-06
Identities = 23/52 (44%), Positives = 34/52 (65%), Gaps = 1/52 (1%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNY 111
+ ALY+Y+A++ +LSF KG+ F + E DW+EA + A GK G +P NY
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNY 146
>CE29645 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 286
Score = 50.8 bits (120), Expect = 5e-06
Identities = 27/69 (39%), Positives = 41/69 (59%), Gaps = 4/69 (5%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHV---QQEENDWYEASNPADGKRGMVPKNYFEIFG 116
+V+ ALY++ A S+ ELSF KG+ + + + DW+ A N A G G+VP+NY E+
Sbjct: 104 QVVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARN-ASGTTGLVPRNYIEVVV 162
Query: 117 RTRPNSHAS 125
+S AS
Sbjct: 163 NDSSSSKAS 171
Score = 48.5 bits (114), Expect = 3e-05
Identities = 39/149 (26%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFEI 114
S + V+K + Y+ + EL KGDF +V ++ D W++ P +G G P NY E
Sbjct: 3 SKTKAVVK--FTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAP-NGGVGWFPSNYVE- 58
Query: 115 FGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAE 174
+++ + NRN + + S+ + LY F A
Sbjct: 59 --EVEASTNGNQGSIENRNPAAAA-VPAPIMMQAPPPKLQASRSSFEIQVVVALYSFDAS 115
Query: 175 KADELTAYAGENLFICAH--HDFEWFIAK 201
++EL+ GE L I H HD +W++A+
Sbjct: 116 SSEELSFKKGERLEIVDHPEHDPDWWMAR 144
>CE29644 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 398
Score = 50.8 bits (120), Expect = 5e-06
Identities = 27/69 (39%), Positives = 41/69 (59%), Gaps = 4/69 (5%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHV---QQEENDWYEASNPADGKRGMVPKNYFEIFG 116
+V+ ALY++ A S+ ELSF KG+ + + + DW+ A N A G G+VP+NY E+
Sbjct: 216 QVVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARN-ASGTTGLVPRNYIEVVV 274
Query: 117 RTRPNSHAS 125
+S AS
Sbjct: 275 NDSSSSKAS 283
Score = 48.5 bits (114), Expect = 3e-05
Identities = 39/149 (26%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFEI 114
S + V+K + Y+ + EL KGDF +V ++ D W++ P +G G P NY E
Sbjct: 115 SKTKAVVK--FTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAP-NGGVGWFPSNYVE- 170
Query: 115 FGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAE 174
+++ + NRN + + S+ + LY F A
Sbjct: 171 --EVEASTNGNQGSIENRNPAAAA-VPAPIMMQAPPPKLQASRSSFEIQVVVALYSFDAS 227
Query: 175 KADELTAYAGENLFICAH--HDFEWFIAK 201
++EL+ GE L I H HD +W++A+
Sbjct: 228 SSEELSFKKGERLEIVDHPEHDPDWWMAR 256
Score = 35.0 bits (79), Expect = 0.31
Identities = 28/151 (18%), Positives = 52/151 (33%), Gaps = 12/151 (7%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFE----- 113
E + Y+Y AQ EL+ K + + + +W++ N ++ G VP NY
Sbjct: 3 EDYVVVKYDYLAQEEQELTIKKNERLKLLDDSKNWWKVMNDSNSV-GFVPSNYVRKESIV 61
Query: 114 ------IFGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIV 167
I G R + +S + R + P A+V
Sbjct: 62 DKAKGTIKGLARGRNRSSDPEPEERLNGIARLAFSLNNNCAVTPSSNKIPMMSSKTKAVV 121
Query: 168 LYDFQAEKADELTAYAGENLFICAHHDFEWF 198
+ ++ DEL G+ +++ W+
Sbjct: 122 KFTYEPRLEDELGLTKGDFVYVVEKSTDGWW 152
>Hs4504357 [T] KOG0197 Tyrosine kinases
Length = 505
Score = 49.7 bits (117), Expect = 1e-05
Identities = 22/59 (37%), Positives = 36/59 (60%)
Query: 53 KDISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNY 111
++ S + ++ ALY+Y+A +LSF KGD V +E +W++A + A K G +P NY
Sbjct: 53 REAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNY 111
>Hs13653487 [T] KOG0197 Tyrosine kinases
Length = 505
Score = 49.7 bits (117), Expect = 1e-05
Identities = 22/59 (37%), Positives = 36/59 (60%)
Query: 53 KDISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNY 111
++ S + ++ ALY+Y+A +LSF KGD V +E +W++A + A K G +P NY
Sbjct: 53 REAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNY 111
>Hs4503823 [T] KOG0197 Tyrosine kinases
Length = 537
Score = 49.3 bits (116), Expect = 2e-05
Identities = 21/49 (42%), Positives = 33/49 (66%), Gaps = 1/49 (2%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNY 111
ALY+Y+A++ +LSF+KG+ F + E DW+EA + G+ G +P NY
Sbjct: 89 ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNY 137
>CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 49.3 bits (116), Expect = 2e-05
Identities = 36/144 (25%), Positives = 68/144 (47%), Gaps = 6/144 (4%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNSH 123
A + ++A++ +LSF KGD V +++ ++ NPA G+ G PK+Y + G T S
Sbjct: 799 AQFQWRARNEEDLSFAKGDTIEVLEKQEMKWKGRNPA-GEIGWFPKSYVKEVGAT--TST 855
Query: 124 ASPVKSINR--NGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADELTA 181
+P+ S ++ G+ G+ + V+YDF+A + +L
Sbjct: 856 TTPIVSPSKASAGAPGAAAGAQYDVVPSDVTLQASETAPQQQLYTVIYDFEAVETTDLAL 915
Query: 182 YAGENLFICAHHDFEWFIAKPIGR 205
+ G+ + + +D EW+ + GR
Sbjct: 916 HVGDTILVLEKND-EWWKGRCNGR 938
Score = 38.1 bits (87), Expect = 0.036
Identities = 20/63 (31%), Positives = 31/63 (48%), Gaps = 2/63 (3%)
Query: 53 KDISSPEKVIKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPAD-GKRGMVPKN 110
++ +SP A+Y+Y+A EL F GD V + E +W+ D K G+ P N
Sbjct: 1033 EEAASPATRATAVYDYEASQPDELGFKTGDVIIVTDKSEAEWWSGHREQDPSKSGLFPSN 1092
Query: 111 YFE 113
Y +
Sbjct: 1093 YVQ 1095
Score = 35.4 bits (80), Expect = 0.23
Identities = 14/56 (25%), Positives = 33/56 (58%), Gaps = 2/56 (3%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEI 114
+++ +Y+++A +L+ + GD V ++ ++W++ +G+ G+ P NY EI
Sbjct: 896 QQLYTVIYDFEAVETTDLALHVGDTILVLEKNDEWWKGR--CNGREGIFPANYVEI 949
>7294071 [Z] KOG1702 Nebulin repeat protein
Length = 594
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/59 (38%), Positives = 35/59 (58%), Gaps = 1/59 (1%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGD-FFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
S+ +V +A+Y+Y+AQ E+SF +GD F V+ ++ W GK GM+P NY E
Sbjct: 532 STAMRVYRAIYDYEAQDVDEVSFREGDVIFEVESIDSGWMTGRVERTGKTGMLPANYVE 590
>Hs4505573 [F] KOG2070 Guanine nucleotide exchange factor
Length = 646
Score = 48.5 bits (114), Expect = 3e-05
Identities = 28/74 (37%), Positives = 43/74 (57%), Gaps = 4/74 (5%)
Query: 54 DISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQ-EENDWYEASNPADGKRGMVPKNYF 112
D S+ + V++A +N+Q + ELSF+KGD HV + EE W+E + +G+ G P NY
Sbjct: 3 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGT--LNGRTGWFPSNYV 60
Query: 113 -EIFGRTRPNSHAS 125
E+ +P S S
Sbjct: 61 REVKASEKPVSPKS 74
>Hs22027528 [F] KOG2070 Guanine nucleotide exchange factor
Length = 782
Score = 48.5 bits (114), Expect = 3e-05
Identities = 28/74 (37%), Positives = 43/74 (57%), Gaps = 4/74 (5%)
Query: 54 DISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQ-EENDWYEASNPADGKRGMVPKNYF 112
D S+ + V++A +N+Q + ELSF+KGD HV + EE W+E + +G+ G P NY
Sbjct: 160 DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGT--LNGRTGWFPSNYV 217
Query: 113 -EIFGRTRPNSHAS 125
E+ +P S S
Sbjct: 218 REVKASEKPVSPKS 231
>Hs4557785 [C] KOG4773 NADPH oxidase
Length = 390
Score = 48.1 bits (113), Expect = 3e-05
Identities = 32/144 (22%), Positives = 64/144 (44%), Gaps = 9/144 (6%)
Query: 314 ETFFLQDDKYWFQVSCQLSNNTTRILKRYYEDFYDLQVKLLDIFPAEGGKLRDTNGQWTK 373
E F+ Y + + + + +++ R + + Y+ L ++FP E G + N
Sbjct: 15 EKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPEN----- 69
Query: 374 RIMPYIPGPVPYVTDTISKKRKDDLNIYVKDLISLPPHISQSHLVKGLFAVKNNGF---- 429
RI+P++P P + ++ R+ L Y L+SLP IS+ + F V+ +
Sbjct: 70 RIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKVRPDDLKLPT 129
Query: 430 DREISNDETVELDVKGRADDSTLT 453
D + ET + G++ + +T
Sbjct: 130 DNQTKKPETYLMPKDGKSTATDIT 153
>Hs22046240 [C] KOG4773 NADPH oxidase
Length = 278
Score = 48.1 bits (113), Expect = 3e-05
Identities = 32/144 (22%), Positives = 64/144 (44%), Gaps = 9/144 (6%)
Query: 314 ETFFLQDDKYWFQVSCQLSNNTTRILKRYYEDFYDLQVKLLDIFPAEGGKLRDTNGQWTK 373
E F+ Y + + + + +++ R + + Y+ L ++FP E G + N
Sbjct: 15 EKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPEN----- 69
Query: 374 RIMPYIPGPVPYVTDTISKKRKDDLNIYVKDLISLPPHISQSHLVKGLFAVKNNGF---- 429
RI+P++P P + ++ R+ L Y L+SLP IS+ + F V+ +
Sbjct: 70 RIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKVRPDDLKLPT 129
Query: 430 DREISNDETVELDVKGRADDSTLT 453
D + ET + G++ + +T
Sbjct: 130 DNQTKKPETYLMPKDGKSTATDIT 153
>CE01784 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 228
Score = 47.8 bits (112), Expect = 5e-05
Identities = 21/74 (28%), Positives = 44/74 (59%), Gaps = 3/74 (4%)
Query: 54 DISSPEKVIKALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYF 112
D++ K ++AL+++ Q +GEL+F +GD + +++ +W+E + +RG+ P NY
Sbjct: 151 DMNVETKFVQALFDFNPQESGELAFKRGDVITLINKDDPNWWEGQ--LNNRRGIFPSNYV 208
Query: 113 EIFGRTRPNSHASP 126
+ + NS+ +P
Sbjct: 209 CPYNSNKSNSNVAP 222
Score = 39.3 bits (90), Expect = 0.016
Identities = 20/53 (37%), Positives = 30/53 (55%), Gaps = 4/53 (7%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEEND--WYEASNPADGKRGMVPKNYFEI 114
A +++QA S ELSF +G+ V ++ D WY+A DG G +P NY +
Sbjct: 5 AEHDFQAGSPDELSFKRGNTLKVLNKDEDPHWYKAE--LDGNEGFIPSNYIRM 55
>Hs5730001 [D] KOG0515 p53-interacting protein 53BP/ASPP contains ankyrin and
SH3 domains
Length = 351
Score = 47.4 bits (111), Expect = 6e-05
Identities = 25/63 (39%), Positives = 38/63 (59%), Gaps = 6/63 (9%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQ----EENDWYEASNPADGKRGMVPKNYFEIFGR 117
+ AL++Y A+ ELSF +G+ V + EE DW+ A+ G+ G VP+NYF +F R
Sbjct: 286 VYALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWAA--LHGQEGYVPRNYFGLFPR 343
Query: 118 TRP 120
+P
Sbjct: 344 VKP 346
>Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 666
Score = 47.4 bits (111), Expect = 6e-05
Identities = 39/149 (26%), Positives = 66/149 (44%), Gaps = 33/149 (22%)
Query: 57 SPEKV---IKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYF 112
+PEK KA+Y+++AQ++ ELSF KGD ++ ++ + +WYE + G+ G+ P +Y
Sbjct: 426 TPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 483
Query: 113 EIFGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQ 172
E + P A P + P +G AI Y+F
Sbjct: 484 E---KLTPPEKAQPARP----------------------PPPAQPGEIGE--AIAKYNFN 516
Query: 173 AEKADELTAYAGENLFICAHHDFEWFIAK 201
A+ EL+ G+ + + D W+ K
Sbjct: 517 ADTNVELSLRKGDRVILLKRVDQNWYEGK 545
Score = 42.0 bits (97), Expect = 0.002
Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 14/143 (9%)
Query: 64 ALYNYQAQSAGELSFNKGD-FFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNS 122
A YN+ A + ELS KGD +++ + +WYE P ++G+ P +Y E+ + +
Sbjct: 511 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 570
Query: 123 HASPVKSI------NRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKA 176
P I +R S+ SN P LY++
Sbjct: 571 EDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQ-------ALYNYTPRNE 623
Query: 177 DELTAYAGENLFICAHHDFEWFI 199
DEL + + + D WF+
Sbjct: 624 DELELRESDVIDVMEKCDDGWFV 646
>Hs22046608 [C] KOG4773 NADPH oxidase
Length = 390
Score = 47.4 bits (111), Expect = 6e-05
Identities = 32/144 (22%), Positives = 64/144 (44%), Gaps = 9/144 (6%)
Query: 314 ETFFLQDDKYWFQVSCQLSNNTTRILKRYYEDFYDLQVKLLDIFPAEGGKLRDTNGQWTK 373
E F+ Y + + + + +++ R + + Y+ L ++FP E G + N
Sbjct: 15 EKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPEN----- 69
Query: 374 RIMPYIPGPVPYVTDTISKKRKDDLNIYVKDLISLPPHISQSHLVKGLFAVKNNGF---- 429
RI+P++P P + ++ R+ L Y L+SLP IS+ + F V+ +
Sbjct: 70 RIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPT 129
Query: 430 DREISNDETVELDVKGRADDSTLT 453
D + ET + G++ + +T
Sbjct: 130 DNQTKKPETYLMPKDGKSTATDIT 153
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 5/63 (7%)
Query: 54 DISSPE--KVIKALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKN 110
DI+ P + +A+ NY+ S E++ + GD V++ E+ W+ A KRG +P +
Sbjct: 151 DITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPAS 208
Query: 111 YFE 113
+ E
Sbjct: 209 FLE 211
>Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 1100
Score = 47.4 bits (111), Expect = 6e-05
Identities = 39/149 (26%), Positives = 66/149 (44%), Gaps = 33/149 (22%)
Query: 57 SPEKV---IKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYF 112
+PEK KA+Y+++AQ++ ELSF KGD ++ ++ + +WYE + G+ G+ P +Y
Sbjct: 860 TPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYV 917
Query: 113 EIFGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQ 172
E + P A P + P +G AI Y+F
Sbjct: 918 E---KLTPPEKAQPARP----------------------PPPAQPGEIGE--AIAKYNFN 950
Query: 173 AEKADELTAYAGENLFICAHHDFEWFIAK 201
A+ EL+ G+ + + D W+ K
Sbjct: 951 ADTNVELSLRKGDRVILLKRVDQNWYEGK 979
Score = 42.0 bits (97), Expect = 0.002
Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 14/143 (9%)
Query: 64 ALYNYQAQSAGELSFNKGD-FFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNS 122
A YN+ A + ELS KGD +++ + +WYE P ++G+ P +Y E+ + +
Sbjct: 945 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 1004
Query: 123 HASPVKSI------NRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKA 176
P I +R S+ SN P LY++
Sbjct: 1005 EDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQ-------ALYNYTPRNE 1057
Query: 177 DELTAYAGENLFICAHHDFEWFI 199
DEL + + + D WF+
Sbjct: 1058 DELELRESDVIDVMEKCDDGWFV 1080
>Hs5729856 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 217
Score = 46.6 bits (109), Expect = 1e-04
Identities = 23/53 (43%), Positives = 32/53 (59%), Gaps = 4/53 (7%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEEND--WYEASNPADGKRGMVPKNYFEI 114
ALY++QA + EL+FNKGD + E+D WY+A G G +PKNY +
Sbjct: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAE--LRGVEGFIPKNYIRV 55
Score = 30.0 bits (66), Expect = 9.8
Identities = 14/52 (26%), Positives = 29/52 (54%), Gaps = 3/52 (5%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFE 113
+A +++ AQ +LSF +GD V ++ + W+ + G+ G P++Y +
Sbjct: 164 QAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR--SCGRVGFFPRSYVQ 213
>Hs4504111 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 217
Score = 46.2 bits (108), Expect = 1e-04
Identities = 24/53 (45%), Positives = 33/53 (61%), Gaps = 4/53 (7%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEEND--WYEASNPADGKRGMVPKNYFEI 114
A Y+++A + ELSF +GD V EE D WY+A +GK G +PKNY E+
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYIEM 55
Score = 44.3 bits (103), Expect = 5e-04
Identities = 19/51 (37%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNY 111
++AL+++ Q GEL F +GDF HV + +W++ + G+ GM P+NY
Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA--CHGQTGMFPRNY 209
>7294461 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 531
Score = 46.2 bits (108), Expect = 1e-04
Identities = 22/53 (41%), Positives = 32/53 (59%), Gaps = 2/53 (3%)
Query: 63 KALYNYQAQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGMVPKNYFEI 114
+ALY+YQA E++F+ GD H+ Q + W++ P DG G+ P NY EI
Sbjct: 478 RALYDYQAADETEITFDPGDVITHIDQIDEGWWQGLGP-DGTYGLFPANYVEI 529
>Hs4758794 [Z] KOG1702 Nebulin repeat protein
Length = 6669
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/59 (37%), Positives = 33/59 (55%), Gaps = 1/59 (1%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGD-FFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
S+ K+ +A+Y+Y A A E+SF GD +VQ + W + G+ GM+P NY E
Sbjct: 6609 STAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDEGWMYGTVQRTGRTGMLPANYVE 6667
>Hs4505055 [T] KOG0197 Tyrosine kinases
Length = 512
Score = 44.7 bits (104), Expect = 4e-04
Identities = 20/59 (33%), Positives = 30/59 (49%)
Query: 53 KDISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNY 111
KD ++ ALY Y +LSF KG+ V +E +W++A + K G +P NY
Sbjct: 59 KDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNY 117
>Hs5453758 [Z] KOG1702 Nebulin repeat protein
Length = 1014
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/55 (36%), Positives = 32/55 (57%), Gaps = 1/55 (1%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGMVPKNYFE 113
+ +A+Y+Y AQ E+SF GD+ +VQ ++ W + G+ GM+P NY E
Sbjct: 957 RTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
>7296156 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 548
Score = 44.3 bits (103), Expect = 5e-04
Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 4/82 (4%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV---QQEENDWYEASNPADGKRGMVPKNYFEIFGR 117
++ ALY++ + + ELSF KGD + + DWY+A N G+ G+VP+NY +
Sbjct: 328 IVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARN-NQGQVGLVPRNYLQELND 386
Query: 118 TRPNSHASPVKSINRNGSVGSN 139
+ + S GSN
Sbjct: 387 YLATPYRNASASAGNGNGGGSN 408
Score = 43.9 bits (102), Expect = 7e-04
Identities = 35/142 (24%), Positives = 62/142 (43%), Gaps = 11/142 (7%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPN 121
+ A Y+Y AQ A EL K + + + + W+ N + + G VP NY + + +P+
Sbjct: 155 VVAKYDYAAQGAQELDLRKNERYLLLDDSKHWWRVQN-SRNQSGYVPSNYVK---KEKPS 210
Query: 122 SHASPVKSINR-NGSVGSNXXXXXXXXXXXXXXXXXPSN----MGTLYAIVLYDFQAEKA 176
S K + + +GS P + +GT A+V Y++QA++
Sbjct: 211 LFDSIKKKVKKGSGSKTLPNCSPSRQVESPTMSRRLPPDPAEAIGT--AVVKYNYQAQQP 268
Query: 177 DELTAYAGENLFICAHHDFEWF 198
DEL+ G + I + W+
Sbjct: 269 DELSLTKGTRILILEKSNDGWW 290
Score = 33.1 bits (74), Expect = 1.2
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 3/47 (6%)
Query: 66 YNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNY 111
YNYQAQ ELS KG + ++ ND W+ + G P NY
Sbjct: 261 YNYQAQQPDELSLTKGTRILILEKSNDGWWRGQ--SGNSVGWFPSNY 305
>7300664_2 [TUZ] KOG2856 Adaptor protein PACSIN
Length = 481
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/60 (33%), Positives = 33/60 (54%)
Query: 54 DISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
D P +KALY+Y+ + EL+F +GD F ++E++ +G+ G+ P NY E
Sbjct: 420 DNGEPGVPVKALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRMNGRVGLYPANYVE 479
>Hs20541236 [C] KOG4773 NADPH oxidase
Length = 366
Score = 43.9 bits (102), Expect = 7e-04
Identities = 32/135 (23%), Positives = 61/135 (44%), Gaps = 11/135 (8%)
Query: 323 YWFQVSCQLSNNTTRILKRYYEDFYDLQVKLLDIFPAEGGKLRDTNGQWTKRIMPYIPGP 382
Y F V Q + + +++ R + + Y+ L ++FP E G + N RI+P++P P
Sbjct: 2 YMFLVKWQ--DLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPEN-----RIIPHLPAP 54
Query: 383 VPYVTDTISKKRKDDLNIYVKDLISLPPHISQSHLVKGLFAVKNNGF----DREISNDET 438
+ ++ + L Y L+SLP IS+ + F V+ + D + ET
Sbjct: 55 KWFDGQRAAENHQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPET 114
Query: 439 VELDVKGRADDSTLT 453
+ G++ + +T
Sbjct: 115 YLMPKDGKSTATDIT 129
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/63 (30%), Positives = 34/63 (53%), Gaps = 5/63 (7%)
Query: 54 DISSPE--KVIKALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKN 110
DI+ P + +A+ NY+ S E++ + GD V++ E+ W+ A KRG +P +
Sbjct: 127 DITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKA--KRGWIPAS 184
Query: 111 YFE 113
+ E
Sbjct: 185 FLE 187
>SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding proteins
Length = 857
Score = 43.5 bits (101), Expect = 9e-04
Identities = 23/57 (40%), Positives = 33/57 (57%), Gaps = 3/57 (5%)
Query: 58 PEKVIKALYNYQAQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGMVPKNYFE 113
P K +KA+Y+YQAQ ELSF + + +V + +W+E G RG+ P NY E
Sbjct: 801 PGKSVKAIYDYQAQEDNELSFFEDEIIANVDCVDPNWWEGE--CHGHRGLFPSNYVE 855
Score = 33.5 bits (75), Expect = 0.89
Identities = 24/121 (19%), Positives = 49/121 (39%), Gaps = 28/121 (23%)
Query: 65 LYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNSHA 124
+Y+Y + E+ + + + + +D + + G++G+ P NY EI G PN A
Sbjct: 733 IYDYSPEEENEIELVENEQIQILEFVDDGWWLGENSKGQQGLFPSNYVEITG---PNETA 789
Query: 125 SPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADELTAYAG 184
+ + + G G + +YD+QA++ +EL+ +
Sbjct: 790 NNPPAEPQAGGPGKSVK-------------------------AIYDYQAQEDNELSFFED 824
Query: 185 E 185
E
Sbjct: 825 E 825
>SPAC20G8.05c [D] KOG2398 Predicted proline-serine-threonine
phosphatase-interacting protein (PSTPIP)
Length = 927
Score = 43.5 bits (101), Expect = 9e-04
Identities = 23/53 (43%), Positives = 33/53 (61%), Gaps = 3/53 (5%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHV-QQEENDWY--EASNPADGKRGMVPKNYFE 113
ALY+YQAQ E+SF KGD V + +E+ W+ E N + KRG+ P N+ +
Sbjct: 873 ALYDYQAQIPEEISFQKGDTLMVLRTQEDGWWDGEIINVPNSKRGLFPSNFVQ 925
>Hs20533984 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 141
Score = 43.5 bits (101), Expect = 9e-04
Identities = 22/65 (33%), Positives = 36/65 (54%), Gaps = 6/65 (9%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFEIFGRTRPN 121
KALY+Y+ + G+L FNKGD ++++ + WY G +G +P +Y + +P
Sbjct: 45 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGE--LHGTQGFLPASYIQCI---QPL 99
Query: 122 SHASP 126
HA P
Sbjct: 100 PHAPP 104
>CE27551 [T] KOG0197 Tyrosine kinases
Length = 558
Score = 43.5 bits (101), Expect = 9e-04
Identities = 19/53 (35%), Positives = 32/53 (59%), Gaps = 1/53 (1%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNY 111
+ + ALY Y +++ G+LSF KGD ++ N DW+ + G+ G VP+N+
Sbjct: 74 ETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNF 126
>7292519 [T] KOG0197 Tyrosine kinases
Length = 552
Score = 43.5 bits (101), Expect = 9e-04
Identities = 19/54 (35%), Positives = 33/54 (60%), Gaps = 1/54 (1%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNY 111
++V+ ALY+Y+++ +LSF KGD V E+DW+ N + G++P N+
Sbjct: 97 KRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNF 150
>YFR024c-a [S] KOG1843 Uncharacterized conserved protein
Length = 451
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/62 (35%), Positives = 36/62 (57%), Gaps = 7/62 (11%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHV---QQEENDWYEASNPADGKRGMVPKNYF 112
SSP+ V ALY++ + +G+L F KGD + +NDW+ + +G+ G+ P NY
Sbjct: 393 SSPKAV--ALYSFAGEESGDLPFRKGDVITILKKSDSQNDWW--TGRVNGREGIFPANYV 448
Query: 113 EI 114
E+
Sbjct: 449 EL 450
>YFR024c [S] KOG1843 Uncharacterized conserved protein
Length = 373
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/62 (35%), Positives = 36/62 (57%), Gaps = 7/62 (11%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHV---QQEENDWYEASNPADGKRGMVPKNYF 112
SSP+ V ALY++ + +G+L F KGD + +NDW+ + +G+ G+ P NY
Sbjct: 315 SSPKAV--ALYSFAGEESGDLPFRKGDVITILKKSDSQNDWW--TGRVNGREGIFPANYV 370
Query: 113 EI 114
E+
Sbjct: 371 EL 372
>YDR388w [U] KOG3771 Amphiphysin
Length = 482
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/58 (36%), Positives = 37/58 (63%), Gaps = 5/58 (8%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQ---EENDWYEASNPADGKRGMVPKNYFEI 114
+ + ALY+YQAQ+AG+LSF G + Q + N+W+ + +G++G+ P NY ++
Sbjct: 424 ETVTALYDYQAQAAGDLSFPAGAVIEIVQRTPDVNEWW--TGRYNGQQGVFPGNYVQL 479
>HsM8923232 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 596
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/66 (31%), Positives = 36/66 (53%), Gaps = 1/66 (1%)
Query: 66 YNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNSHAS 125
Y++QA+++ ELS + D V + W++ +PA G+ G VP N + R + S
Sbjct: 360 YDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPA-GQEGYVPYNILTPYPGPRLHHSQS 418
Query: 126 PVKSIN 131
P +S+N
Sbjct: 419 PARSLN 424
>Hs21264608 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 723
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/66 (31%), Positives = 36/66 (53%), Gaps = 1/66 (1%)
Query: 66 YNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNSHAS 125
Y++QA+++ ELS + D V + W++ +PA G+ G VP N + R + S
Sbjct: 487 YDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPA-GQEGYVPYNILTPYPGPRLHHSQS 545
Query: 126 PVKSIN 131
P +S+N
Sbjct: 546 PARSLN 551
>Hs21264606 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 596
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/66 (31%), Positives = 36/66 (53%), Gaps = 1/66 (1%)
Query: 66 YNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNSHAS 125
Y++QA+++ ELS + D V + W++ +PA G+ G VP N + R + S
Sbjct: 360 YDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPA-GQEGYVPYNILTPYPGPRLHHSQS 418
Query: 126 PVKSIN 131
P +S+N
Sbjct: 419 PARSLN 424
>Hs8400706 [T] KOG4792 Crk family adapters
Length = 304
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/78 (28%), Positives = 39/78 (49%), Gaps = 13/78 (16%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFE------- 113
++AL+++ +L F KGD ++ + E W+ A + ++GKRGM+P Y E
Sbjct: 137 VRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED-SEGKRGMIPVPYVEKYRPASA 195
Query: 114 ----IFGRTRPNSHASPV 127
+ G + SH P+
Sbjct: 196 SVSALIGGNQEGSHPQPL 213
>Hs7662208 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating
proteins
Length = 814
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/64 (40%), Positives = 36/64 (55%), Gaps = 6/64 (9%)
Query: 53 KDISSPEKVIKALYNYQAQSAGELSFNKGDFF---HVQQEENDWYEASNPADGKRGMVPK 109
+D S+P + KALY +A+ ELSF G F H QE W E + +GK G++P+
Sbjct: 752 EDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPG-WLEGT--LNGKTGLIPE 808
Query: 110 NYFE 113
NY E
Sbjct: 809 NYVE 812
>Hs22065489 [T] KOG4792 Crk family adapters
Length = 304
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/78 (28%), Positives = 39/78 (49%), Gaps = 13/78 (16%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFE------- 113
++AL+++ +L F KGD ++ + E W+ A + ++GKRGM+P Y E
Sbjct: 137 VRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED-SEGKRGMIPVPYVEKYRPASA 195
Query: 114 ----IFGRTRPNSHASPV 127
+ G + SH P+
Sbjct: 196 SVSALIGGNQEGSHPQPL 213
>Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 223
Score = 42.7 bits (99), Expect = 0.001
Identities = 39/152 (25%), Positives = 61/152 (39%), Gaps = 34/152 (22%)
Query: 53 KDISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEN--DWYEASNPADGKR---GMV 107
K + S E+ I A+Y YQ+ G+L+F +GD V ++ N W+E A GK+ G
Sbjct: 73 KPVVSGEEFI-AMYTYQSSEQGDLTFQQGDVILVTKKMNPGGWWEGELQARGKKRQIGWF 131
Query: 108 PKNYFEIFG-RTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAI 166
P NY ++ T + P KS + I
Sbjct: 132 PANYVKLLSPGTSKITPTEPPKS---------------------------TALAAVCQVI 164
Query: 167 VLYDFQAEKADELTAYAGENLFICAHHDFEWF 198
+YD+ A+ DEL G+ + I D +W+
Sbjct: 165 GMYDYTAQNDDELAFNKGQIINILNKEDPDWW 196
Score = 41.2 bits (95), Expect = 0.004
Identities = 18/51 (35%), Positives = 33/51 (64%), Gaps = 3/51 (5%)
Query: 65 LYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEI 114
+Y+Y AQ+ EL+FNKG ++ +E+ DW++ +G+ G+ P NY ++
Sbjct: 166 MYDYTAQNDDELAFNKGQIINILNKEDPDWWKGE--VNGQVGLFPSNYVKL 214
>Hs20149528 [D] KOG2398 Predicted proline-serine-threonine
phosphatase-interacting protein (PSTPIP)
Length = 416
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/59 (38%), Positives = 34/59 (56%), Gaps = 3/59 (5%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFE 113
+SP + +ALY+Y AQ+ EL + GD V E E+ W+ +G+RG VP +Y E
Sbjct: 358 ASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVER--NGQRGFVPGSYLE 414
>YHR016c [S] KOG1843 Uncharacterized conserved protein
Length = 468
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHV---QQEENDWYEASNPADGKRGMVPKNYFEI 114
ALYN+ + G+L+F KGD + +NDW+ + +GK G+ P NY +
Sbjct: 416 ALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWW--TGRTNGKEGIFPANYVRV 467
>Hs5453754 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 377
Score = 42.4 bits (98), Expect = 0.002
Identities = 35/145 (24%), Positives = 54/145 (37%), Gaps = 9/145 (6%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRT 118
E V+ A ++Y AQ EL K + + + W+ N + K G VP NY E R
Sbjct: 4 EVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMN-KTGFVPSNYVE---RK 59
Query: 119 RPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLY-----AIVLYDFQA 173
AS VK++ +G LY A V +++ A
Sbjct: 60 NSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMA 119
Query: 174 EKADELTAYAGENLFICAHHDFEWF 198
E+ DEL+ G + + W+
Sbjct: 120 EREDELSLIKGTKVIVMEKCSDGWW 144
Score = 40.4 bits (93), Expect = 0.007
Identities = 24/69 (34%), Positives = 37/69 (52%), Gaps = 4/69 (5%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV-QQEEND--WYEASNPADGKRGMVPKNYFEIFGR 117
V++ALY + + + EL+F KGD V ++ END W++ +G G+VPKNY +
Sbjct: 194 VVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKC-RKINGMVGLVPKNYVTVMQN 252
Query: 118 TRPNSHASP 126
S P
Sbjct: 253 NPLTSGLEP 261
>Hs4885609 [T] KOG0197 Tyrosine kinases
Length = 536
Score = 42.4 bits (98), Expect = 0.002
Identities = 19/49 (38%), Positives = 31/49 (62%), Gaps = 1/49 (2%)
Query: 64 ALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNY 111
ALY+Y++++ +LSF KG+ V E DW+ A + + G+ G +P NY
Sbjct: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNY 139
>Hs20533142 [O] KOG2177 Predicted E3 ubiquitin ligase
Length = 888
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/53 (37%), Positives = 31/53 (57%), Gaps = 3/53 (5%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEI 114
KALYNY+ + G+L F+KGD + +Q + +WY +G G P N+ +I
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGE--VNGIHGFFPTNFVQI 190
Score = 34.7 bits (78), Expect = 0.40
Identities = 15/52 (28%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFE 113
+ + +Y QS EL +GD V ++ D W++ + +GK G+ P ++ E
Sbjct: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 33.5 bits (75), Expect = 0.89
Identities = 21/69 (30%), Positives = 36/69 (51%), Gaps = 3/69 (4%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEIFGRTR 119
V A+Y Y + EL KG+ F V ++ ++ W++ ++ K G+ P NY + TR
Sbjct: 449 VYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNY--VAPVTR 506
Query: 120 PNSHASPVK 128
++AS K
Sbjct: 507 AVTNASQAK 515
>Hs4885153 [T] KOG4792 Crk family adapters
Length = 303
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 7/75 (9%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEIFGRTRP 120
++ LY++ A +L F KG+ + ++ E W+ A N DG+ GM+P Y E R+ P
Sbjct: 128 VRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNK-DGRVGMIPVPYVEKLVRSSP 186
Query: 121 NSHASPVKSINRNGS 135
+ K NRN +
Sbjct: 187 HG-----KHGNRNSN 196
>Hs4506929 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 368
Score = 42.0 bits (97), Expect = 0.002
Identities = 20/53 (37%), Positives = 33/53 (61%), Gaps = 3/53 (5%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEI 114
KALY+++ ++ GEL F++GD + Q + +WYE DG+ G P +Y E+
Sbjct: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGM--LDGQSGFFPLSYVEV 362
>Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 790
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/136 (25%), Positives = 58/136 (41%), Gaps = 37/136 (27%)
Query: 70 AQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGMVPKNYFEIFG------RTRPNS 122
+Q+ GELS +GD ++Q EN++ E D G V + +I R+RPN
Sbjct: 428 SQNPGELSCKRGDVLVMLKQTENNYLECQKGED--TGRVHLSQMKIITPLDEHLRSRPND 485
Query: 123 HASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADELTAY 182
+ K P + G +A+VL+DF AE+ D+L
Sbjct: 486 PSHAQK----------------------------PVDSGAPHAVVLHDFPAEQVDDLNLT 517
Query: 183 AGENLFICAHHDFEWF 198
+GE +++ D +W+
Sbjct: 518 SGEIVYLLEKIDTDWY 533
Score = 40.4 bits (93), Expect = 0.007
Identities = 20/52 (38%), Positives = 31/52 (59%), Gaps = 3/52 (5%)
Query: 63 KALYNYQAQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGMVPKNYFE 113
KALY+++ ++ ELSF GD ++ ++DW S GK G+ PKNY +
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESVDDDW--MSGELMGKSGIFPKNYIQ 785
Score = 35.8 bits (81), Expect = 0.18
Identities = 27/134 (20%), Positives = 55/134 (40%), Gaps = 13/134 (9%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNSH 123
A + Y + ELSF++G+ +++ N+ + A G+ G+ P N+ E
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEW-ARGEVRGRTGIFPLNFVE---------- 626
Query: 124 ASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADELTAYA 183
PV+ +G+ + +++ + L+ F AE +D+L+
Sbjct: 627 --PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKR 684
Query: 184 GENLFICAHHDFEW 197
G+ + I D +W
Sbjct: 685 GDRIQILERLDSDW 698
>Hs20428652 [T] KOG0197 Tyrosine kinases
Length = 509
Score = 42.0 bits (97), Expect = 0.002
Identities = 14/53 (26%), Positives = 32/53 (59%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNY 111
+ ++ AL++Y+ G+L F KG+ + ++ +W++A + G+ G +P N+
Sbjct: 63 DNLVIALHSYEPSHDGDLGFEKGEPLRILEQSGEWWKAQSLTTGQEGFIPFNF 115
>CE24991 [T] KOG0197 Tyrosine kinases
Length = 507
Score = 42.0 bits (97), Expect = 0.002
Identities = 18/49 (36%), Positives = 29/49 (58%), Gaps = 1/49 (2%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNY 111
AL+ Y A++ +LSF K D + + + DW+ A + A G+ G +P NY
Sbjct: 64 ALFQYDARTDDDLSFKKDDILEILNDTQGDWWFARHKATGRTGYIPSNY 112
>Hs8400708 [T] KOG4792 Crk family adapters
Length = 204
Score = 41.6 bits (96), Expect = 0.003
Identities = 18/53 (33%), Positives = 32/53 (59%), Gaps = 2/53 (3%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFE 113
++AL+++ +L F KGD ++ + E W+ A + ++GKRGM+P Y E
Sbjct: 137 VRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED-SEGKRGMIPVPYVE 188
>Hs4505347 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 381
Score = 41.6 bits (96), Expect = 0.003
Identities = 27/81 (33%), Positives = 43/81 (52%), Gaps = 5/81 (6%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV-QQEEND--WYEASNPADGKRGMVPKNYFEIFGR 117
V++ LY + + + EL+F KG+ V ++ END W++ N A G+ G+VPKNY +
Sbjct: 200 VVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLS- 257
Query: 118 TRPNSHASPVKSINRNGSVGS 138
P H + I+ G S
Sbjct: 258 DGPALHPAHAPQISYTGPSSS 278
>Hs18699720 [D] KOG0515 p53-interacting protein 53BP/ASPP contains ankyrin and
SH3 domains
Length = 1090
Score = 41.6 bits (96), Expect = 0.003
Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 6/64 (9%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV----QQEENDWYEASNPADGKRGMVPKNYFEIFG 116
V AL++Y+AQ++ ELSF++GD + + E +W+ A + G VPKN ++
Sbjct: 1023 VAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWAR--LGDREGYVPKNLLGLYP 1080
Query: 117 RTRP 120
R +P
Sbjct: 1081 RIKP 1084
Score = 30.0 bits (66), Expect = 9.8
Identities = 17/46 (36%), Positives = 27/46 (57%), Gaps = 5/46 (10%)
Query: 159 NMGTLYAIVLYDFQAEKADELTAYAGENLFICAHHD---FEWFIAK 201
N G YA L+D++A+ +DEL+ + G+ L I D EW+ A+
Sbjct: 1020 NKGVAYA--LWDYEAQNSDELSFHEGDALTILRRKDESETEWWWAR 1063
>Hs18552166 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 380
Score = 41.6 bits (96), Expect = 0.003
Identities = 27/81 (33%), Positives = 43/81 (52%), Gaps = 5/81 (6%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV-QQEEND--WYEASNPADGKRGMVPKNYFEIFGR 117
V++ LY + + + EL+F KG+ V ++ END W++ N A G+ G+VPKNY +
Sbjct: 199 VVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLS- 256
Query: 118 TRPNSHASPVKSINRNGSVGS 138
P H + I+ G S
Sbjct: 257 DGPALHPAHAPQISYTGPSSS 277
>CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 443
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/53 (37%), Positives = 31/53 (57%), Gaps = 3/53 (5%)
Query: 63 KALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYFEI 114
+AL+++ AQS GEL F +G V Q + +WYE +GK G+ P Y ++
Sbjct: 388 RALFDFDAQSEGELDFKEGTLIELVSQIDENWYEGR--VNGKTGLFPVTYVQV 438
>Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1221
Score = 41.6 bits (96), Expect = 0.003
Identities = 19/51 (37%), Positives = 33/51 (64%), Gaps = 3/51 (5%)
Query: 65 LYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEI 114
+Y+Y AQ+ EL+FNKG +V +E+ DW++ +G+ G+ P NY ++
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGE--VNGQVGLFPSNYVKL 1211
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/62 (32%), Positives = 35/62 (56%), Gaps = 3/62 (4%)
Query: 53 KDISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYF 112
K + S E+ I A+Y Y++ G+L+F +GD V +++ DW+ + K G+ P NY
Sbjct: 999 KPVVSGEEFI-AMYTYESSEQGDLTFQQGDVILVTKKDGDWW--TGTVGDKAGVFPSNYV 1055
Query: 113 EI 114
+
Sbjct: 1056 RL 1057
Score = 40.4 bits (93), Expect = 0.007
Identities = 28/136 (20%), Positives = 61/136 (44%), Gaps = 15/136 (11%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNS 122
+ALY ++A+ L+FNK D V ++++ W+ G++G PK+Y ++
Sbjct: 919 QALYPWRAKKDNHLNFNKNDVITVLEQQDMWW--FGEVQGQKGWFPKSYVKLI------- 969
Query: 123 HASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADELTAY 182
+ P++ ++ S+ S P G + I +Y +++ + +LT
Sbjct: 970 -SGPIR---KSTSMDSGSSESPASLKRVASPAAKPVVSGEEF-IAMYTYESSEQGDLTFQ 1024
Query: 183 AGENLFICAHHDFEWF 198
G+ + + D +W+
Sbjct: 1025 QGD-VILVTKKDGDWW 1039
Score = 33.9 bits (76), Expect = 0.68
Identities = 27/91 (29%), Positives = 41/91 (44%), Gaps = 13/91 (14%)
Query: 55 ISSPEKV----IKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPA------DGKR 104
IS+ E V +ALY ++++S E++ GD V+ E D + P GK
Sbjct: 734 ISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKT 793
Query: 105 GMVPKNYFEIFGRTRPNSHASPVKSINRNGS 135
G P NY E + N +PVK + + S
Sbjct: 794 GWFPANYAE---KIPENEVPAPVKPVTDSTS 821
>SPBC21D10.12 [U] KOG3771 Amphiphysin
Length = 466
Score = 41.2 bits (95), Expect = 0.004
Identities = 21/56 (37%), Positives = 33/56 (58%), Gaps = 5/56 (8%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHV---QQEENDWYEASNPADGKRGMVPKNYFEI 114
+ ALY+Y AQ+AG+LSF+ GD V +N+W+ +G +G P NY ++
Sbjct: 412 VVALYDYAAQAAGDLSFHAGDRIEVVSRTDNQNEWW--IGRLNGAQGQFPGNYVQL 465
>Hs4557377 [T] KOG0197 Tyrosine kinases
Length = 659
Score = 41.2 bits (95), Expect = 0.004
Identities = 20/57 (35%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNY 111
+S K + ALY+Y +A +L KGD + + +E N W+ A + +G+ G +P NY
Sbjct: 213 TSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDK-NGQEGYIPSNY 268
>Hs20550422 [F] KOG2070 Guanine nucleotide exchange factor
Length = 776
Score = 41.2 bits (95), Expect = 0.004
Identities = 25/68 (36%), Positives = 38/68 (55%), Gaps = 4/68 (5%)
Query: 57 SPEKVIKALYNYQAQSAGELSFNKGDFFHVQQ-EENDWYEASNPADGKRGMVPKNYF-EI 114
S + ++KA +N++ + ELS KGD +V + EE W+E + +G+ G P NY EI
Sbjct: 160 SHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGT--LNGRTGWFPSNYVREI 217
Query: 115 FGRTRPNS 122
RP S
Sbjct: 218 KSSERPLS 225
>Hs16418431 [R] KOG4429 Uncharacterized conserved protein contains SH3 and FCH
domains
Length = 428
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/56 (39%), Positives = 33/56 (58%), Gaps = 5/56 (8%)
Query: 60 KVIKALYNYQAQSAGELSFNKGD--FFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
++ KALY++QA+ EL+ KGD H ++EE W+ + N GK+G P Y E
Sbjct: 363 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLN---GKKGHFPAAYVE 415
>7302199 [T] KOG0197 Tyrosine kinases
Length = 517
Score = 41.2 bits (95), Expect = 0.004
Identities = 18/53 (33%), Positives = 30/53 (55%), Gaps = 1/53 (1%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNY 111
K+ ALY+Y A++ +LSF KG+ + + + DW+ A + G +P NY
Sbjct: 66 KIFVALYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTRSEGYIPSNY 118
>7298751 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/77 (28%), Positives = 41/77 (52%), Gaps = 3/77 (3%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFG-RTRPNS 122
A Y Y++ G+LSF+ G+ V ++E +W+ + + GM P NY + T +
Sbjct: 786 AAYPYESAEEGDLSFSAGEMVMVIKKEGEWW--TGTIGSRTGMFPSNYVQKADVGTASTA 843
Query: 123 HASPVKSINRNGSVGSN 139
A PV+S+++ ++ N
Sbjct: 844 AAEPVESLDQETTLNGN 860
Score = 38.5 bits (88), Expect = 0.028
Identities = 23/54 (42%), Positives = 33/54 (60%), Gaps = 4/54 (7%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNY 111
+KVI ALY Y+AQ+ ELSF+K D V ++E +W+ +G G+ P NY
Sbjct: 1028 DKVI-ALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGE--LNGLSGLFPSNY 1078
Score = 32.7 bits (73), Expect = 1.5
Identities = 33/153 (21%), Positives = 59/153 (37%), Gaps = 20/153 (13%)
Query: 57 SPEKVIK--ALYNYQAQSAGELSFNKGDFFHVQQEEN---DWYEASNPADGKRGMVPKNY 111
+PE +K A+Y + A++A E++F GD V E+N W + +G G P++Y
Sbjct: 672 APEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGW--LAGEINGHTGWFPESY 729
Query: 112 FEIFGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTL-------Y 164
E +PV ++ V + P+ L Y
Sbjct: 730 VE----KLEVGEVAPVAAV--EAPVDAQVATVADTYNDNINTSSIPAASADLTAAGDVEY 783
Query: 165 AIVLYDFQAEKADELTAYAGENLFICAHHDFEW 197
I Y +++ + +L+ AGE + + W
Sbjct: 784 YIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWW 816
>Hs5453710 [Z] KOG1702 Nebulin repeat protein
Length = 261
Score = 40.8 bits (94), Expect = 0.006
Identities = 21/55 (38%), Positives = 30/55 (54%), Gaps = 1/55 (1%)
Query: 60 KVIKALYNYQAQSAGELSFNKGD-FFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
K +A+Y+Y A E+SF GD +VQQ ++ W + G GM+P NY E
Sbjct: 205 KRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVE 259
>Hs4758296 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 822
Score = 40.8 bits (94), Expect = 0.006
Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEI 114
+ P+K K+ Y++ A++ ELS K D + + W++ N A G G VP N +I
Sbjct: 530 TQPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRN-ASGDSGFVPNNILDI 587
>Hs19923335 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 671
Score = 40.4 bits (93), Expect = 0.007
Identities = 19/56 (33%), Positives = 33/56 (58%), Gaps = 3/56 (5%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFEI 114
K + +++QAQS EL+ KGD ++ +E + +W E + G+ G+ P NY E+
Sbjct: 383 KAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEH--HGRLGIFPANYVEV 436
Score = 35.0 bits (79), Expect = 0.31
Identities = 16/52 (30%), Positives = 29/52 (55%), Gaps = 1/52 (1%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFEI 114
A Y ++ ELSF KG+ + ++ N+ WYE G++G+ P +Y ++
Sbjct: 461 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV 512
Score = 33.1 bits (74), Expect = 1.2
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNY 111
+A+Y Y+ Q+ EL +GD V Q+ +D W+ + K G P NY
Sbjct: 618 RAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNY 667
>CE28290 [U] KOG3875 Peroxisomal biogenesis protein peroxin
Length = 330
Score = 40.4 bits (93), Expect = 0.007
Identities = 26/68 (38%), Positives = 37/68 (54%), Gaps = 7/68 (10%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-----WYEASNPADGKR-GMVPK 109
++P +AL+++QA + ELSF G+ V +E W AS ADG R G+VP
Sbjct: 234 AAPHYTAQALFDFQASNEQELSFMNGETLRVAPKEEQPRVRGWLLAS-VADGSRIGLVPI 292
Query: 110 NYFEIFGR 117
NY I G+
Sbjct: 293 NYVRIVGK 300
>YGR136w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 241
Score = 40.0 bits (92), Expect = 0.009
Identities = 20/54 (37%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNY 111
E+ ++ALY+++AQ G+LS GD V ++ DWY ++ K G+ P NY
Sbjct: 55 EEYVEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGK--SNNKIGIFPANY 106
>HsM12232453 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 743
Score = 40.0 bits (92), Expect = 0.009
Identities = 22/67 (32%), Positives = 35/67 (51%), Gaps = 4/67 (5%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTR 119
K +K LY++ A++A ELS K + V ++ W++ + G+ G VP N I G R
Sbjct: 523 KYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRS-RSGQAGYVPCN---ILGEAR 578
Query: 120 PNSHASP 126
P +P
Sbjct: 579 PEDAGAP 585
>Hs4505871 [I] KOG1264 Phospholipase C
Length = 1252
Score = 40.0 bits (92), Expect = 0.009
Identities = 21/59 (35%), Positives = 34/59 (57%), Gaps = 2/59 (3%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYFE 113
S P++ +KALY+Y+A+ + ELSF +G H V +E W++ ++ P NY E
Sbjct: 768 SMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQ-YFPSNYVE 825
>Hs21264616 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 715
Score = 40.0 bits (92), Expect = 0.009
Identities = 22/67 (32%), Positives = 35/67 (51%), Gaps = 4/67 (5%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTR 119
K +K LY++ A++A ELS K + V ++ W++ + G+ G VP N I G R
Sbjct: 495 KYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRS-RSGQAGYVPCN---ILGEAR 550
Query: 120 PNSHASP 126
P +P
Sbjct: 551 PEDAGAP 557
>Hs18598741 [I] KOG1264 Phospholipase C
Length = 1265
Score = 40.0 bits (92), Expect = 0.009
Identities = 21/59 (35%), Positives = 34/59 (57%), Gaps = 2/59 (3%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYFE 113
S P++ +KALY+Y+A+ + ELSF +G H V +E W++ ++ P NY E
Sbjct: 768 SMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQ-YFPSNYVE 825
>Hs4506931 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 352
Score = 39.7 bits (91), Expect = 0.012
Identities = 20/53 (37%), Positives = 30/53 (55%), Gaps = 3/53 (5%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEI 114
+ALY+++ ++ GEL F +GD + Q + +WYE G G P NY EI
Sbjct: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGM--LHGHSGFFPINYVEI 346
>Hs19224660 [TUZ] KOG2856 Adaptor protein PACSIN
Length = 424
Score = 39.7 bits (91), Expect = 0.012
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 6/69 (8%)
Query: 54 DISSPEKV-----IKALYNYQAQSAGELSFNKG-DFFHVQQEENDWYEASNPADGKRGMV 107
D SP K ++ALY+Y Q A ELSF G + + +E+ + G+ G+
Sbjct: 355 DEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLY 414
Query: 108 PKNYFEIFG 116
P NY E G
Sbjct: 415 PANYVECVG 423
>7301982 [T] KOG4348 Adaptor protein CMS/SETA
Length = 352
Score = 39.7 bits (91), Expect = 0.012
Identities = 32/134 (23%), Positives = 48/134 (34%), Gaps = 14/134 (10%)
Query: 66 YNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNSHA 124
Y Y A+ EL KG H ++Q W++ + A G GM P N+ +
Sbjct: 11 YEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVRVL--------E 62
Query: 125 SPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADELTAYAG 184
S V S N NG+ GS + V+Y + DELT G
Sbjct: 63 SGVSS-NGNGTTGSGDHIEVGTAVQLRDKSATSNRR----CKVIYSYTQVNDDELTLAVG 117
Query: 185 ENLFICAHHDFEWF 198
+ + + W+
Sbjct: 118 DVIEFLGEVEEGWW 131
>Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1177
Score = 39.7 bits (91), Expect = 0.012
Identities = 19/59 (32%), Positives = 35/59 (59%), Gaps = 3/59 (5%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNYFEIFGRTRPN 121
A+Y+Y A + ELSF+KG +V +++ DW++ +G G+ P NY ++ + P+
Sbjct: 1118 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE--INGVTGLFPSNYVKMTTDSDPS 1174
Score = 37.7 bits (86), Expect = 0.047
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 5/71 (7%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQE---ENDWYEASNPADGKRGMVPKNYFEIFGRTR 119
+ALY ++A++ E+SFN GD V ++ E W S G G P NY E +
Sbjct: 747 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGS--FQGNFGWFPCNYVEKMPSSE 804
Query: 120 PNSHASPVKSI 130
SP K++
Sbjct: 805 NEKAVSPKKAL 815
Score = 35.4 bits (80), Expect = 0.23
Identities = 16/48 (33%), Positives = 27/48 (55%), Gaps = 2/48 (4%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNY 111
ALY Y + G+L+F +G+ V Q++ +W+ S + G+ P NY
Sbjct: 972 ALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGS--IGDRSGIFPSNY 1017
Score = 34.7 bits (78), Expect = 0.40
Identities = 34/137 (24%), Positives = 56/137 (40%), Gaps = 23/137 (16%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPN 121
+AL ++ A+ L+F+K D V +Q+EN W+ G RG PK+Y +I P
Sbjct: 888 QALCSWTAKKDNHLNFSKHDIITVLEQQENWWF---GEVHGGRGWFPKSYVKII----PG 940
Query: 122 SHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADELTA 181
S + +V ++G Y I LY + + + +LT
Sbjct: 941 SEVKREEPEALYAAVNKKPTSAAY-------------SVGEEY-IALYPYSSVEPGDLTF 986
Query: 182 YAGENLFICAHHDFEWF 198
GE + + D EW+
Sbjct: 987 TEGEEILV-TQKDGEWW 1002
>Hs4826844 [Z] KOG0162 Myosin class I heavy chain
Length = 1109
Score = 39.3 bits (90), Expect = 0.016
Identities = 21/50 (42%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQEE-NDWYEASNPADGKRGMVPKNY 111
KALY Y AQ ELSFN D + +E+ + W+ + GK G+ P NY
Sbjct: 1058 KALYAYDAQDTDELSFNANDIIDIIKEDPSGWW--TGRLRGKPGLFPNNY 1105
>Hs4503355 [T] KOG1998 Signaling protein DOCK180
Length = 1865
Score = 39.3 bits (90), Expect = 0.016
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 1/57 (1%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEA-SNPADGKRGMVPKNYFEI 114
EK A YNY A+ A ELS GD H+ + WY + K+G+ P +Y +
Sbjct: 11 EKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHL 67
>CE00538 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 467
Score = 39.3 bits (90), Expect = 0.016
Identities = 33/152 (21%), Positives = 61/152 (39%), Gaps = 27/152 (17%)
Query: 55 ISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFE 113
IS+P + K ++Y + E+ GD + ++ + +W+ N G+VP +Y +
Sbjct: 165 ISTPYGIAK--FDYAPTQSDEMGLRIGDTVLISKKVDAEWFYGENQNQRTFGIVPSSYLD 222
Query: 114 IFGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQA 173
I + A P + +G S+ GT YA +YD+ +
Sbjct: 223 IKIPLKEAFTALPPRPAAPSG-----------------------SSSGT-YATAIYDYNS 258
Query: 174 EKADELTAYAGENLFICAHHDFEWFIAKPIGR 205
+A +L G + + A + EW + GR
Sbjct: 259 NEAGDLNFAVGSQIMVTARVNEEWLEGECFGR 290
Score = 35.4 bits (80), Expect = 0.23
Identities = 33/152 (21%), Positives = 57/152 (36%), Gaps = 23/152 (15%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNYFEI 114
SS A+Y+Y + AG+L+F G V N +W E G+ G+ P + +
Sbjct: 244 SSSGTYATAIYDYNSNEAGDLNFAVGSQIMVTARVNEEWLEGE--CFGRSGIFPSQFVDC 301
Query: 115 FGRTRPNSHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAI-VLYDFQA 173
PN + P+K +N G + V YD+ +
Sbjct: 302 -----PNLYQVPMKQ--------------SAPSSAPSYSHPITNNSGPKQTVTVSYDYDS 342
Query: 174 EKADELTAYAGENLFICAHHDFEWFIAKPIGR 205
A +L + G+ + D +W +A+ G+
Sbjct: 343 GVASDLRLFEGDVITALEDIDAQWLLAECRGQ 374
>7303308 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 211
Score = 39.3 bits (90), Expect = 0.016
Identities = 20/53 (37%), Positives = 29/53 (53%), Gaps = 4/53 (7%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEEND--WYEASNPADGKRGMVPKNYFEI 114
A +++ A + ELSF K + E+D WY A DGK G++P NY E+
Sbjct: 5 AKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYIEM 55
Score = 38.1 bits (87), Expect = 0.036
Identities = 19/61 (31%), Positives = 34/61 (55%), Gaps = 5/61 (8%)
Query: 53 KDISSPEKVIKALYNYQAQSAGELSFNKGDFFHV--QQEENDWYEASNPADGKRGMVPKN 110
+D+ E +++ALY++ Q +GEL F +GD V + +EN W + ++G+ P
Sbjct: 148 RDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWW---NGEIGNRKGIFPAT 204
Query: 111 Y 111
Y
Sbjct: 205 Y 205
>Hs5174647 [T] KOG0197 Tyrosine kinases
Length = 451
Score = 38.9 bits (89), Expect = 0.021
Identities = 20/51 (39%), Positives = 33/51 (64%), Gaps = 4/51 (7%)
Query: 65 LYNYQAQSAGELSFNKGDFFHVQQEENDWYEAS--NPADG--KRGMVPKNY 111
L+++++++ ELSF GD FHV ++E W+ A+ + A G +G VP NY
Sbjct: 16 LWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNY 66
>Hs20070146 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 355
Score = 38.9 bits (89), Expect = 0.021
Identities = 19/62 (30%), Positives = 33/62 (52%), Gaps = 3/62 (4%)
Query: 54 DISSPEKVIKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYF 112
+I + + LY+++ ++ GEL F +GD + Q + +WYE G+ G P NY
Sbjct: 290 NIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGM--IHGESGFFPINYV 347
Query: 113 EI 114
E+
Sbjct: 348 EV 349
>7294985 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 774
Score = 38.5 bits (88), Expect = 0.028
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 15/140 (10%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHV--QQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPN 121
ALY+Y AQ+ EL+ + + V + + + W A N G+ G VP NY +I T +
Sbjct: 549 ALYSYTAQNPDELTIVENEQLEVVGEGDGDGWLRARNYR-GEEGYVPHNYLDIDQETAGS 607
Query: 122 SHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYA------------IVLY 169
+ + R+ S+ P + + A I LY
Sbjct: 608 AFNGTSGNQLRSQISFSSVDYTVDNEDQTVDSMQSPDQVSVIMAPQKRVKSDVEWCIALY 667
Query: 170 DFQAEKADELTAYAGENLFI 189
D+ A DELT G+ + I
Sbjct: 668 DYDATAEDELTFEEGDKIKI 687
Score = 31.2 bits (69), Expect = 4.4
Identities = 21/66 (31%), Positives = 33/66 (49%), Gaps = 14/66 (21%)
Query: 55 ISSPEKVIK-------ALYNYQAQSAGELSFNKGDFFHVQQE-----ENDWYEASNPADG 102
I +P+K +K ALY+Y A + EL+F +GD + + ++ W+E DG
Sbjct: 649 IMAPQKRVKSDVEWCIALYDYDATAEDELTFEEGDKIKIITKTAHGVDDGWWEGE--LDG 706
Query: 103 KRGMVP 108
K G P
Sbjct: 707 KFGNFP 712
>Hs6005826 [TUZ] KOG2856 Adaptor protein PACSIN
Length = 486
Score = 38.1 bits (87), Expect = 0.036
Identities = 21/59 (35%), Positives = 31/59 (51%), Gaps = 1/59 (1%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPAD-GKRGMVPKNYFE 113
S E ++ALY+Y+ Q ELSF GD ++E++ D G+ G+ P NY E
Sbjct: 425 SGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVE 483
>Hs20546302 [O] KOG2177 Predicted E3 ubiquitin ligase
Length = 457
Score = 38.1 bits (87), Expect = 0.036
Identities = 19/53 (35%), Positives = 32/53 (59%), Gaps = 3/53 (5%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFEI 114
KAL NY+ Q+ G+L FNKGD ++++ + +WY+ +G G P + E+
Sbjct: 131 KALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGE--INGISGNFPASSVEV 181
Score = 30.4 bits (67), Expect = 7.5
Identities = 18/57 (31%), Positives = 28/57 (48%), Gaps = 2/57 (3%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNY-FEIFGRT 118
AL++Y A EL KG+ V + ++ W + G+ G+ P NY IF +T
Sbjct: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT 443
>Hs4507191 [Z] KOG0040 Ca2+-binding actin-bundling protein (spectrin) alpha
chain (EF-Hand protein superfamily)
Length = 2472
Score = 37.7 bits (86), Expect = 0.047
Identities = 23/84 (27%), Positives = 42/84 (49%), Gaps = 6/84 (7%)
Query: 54 DISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNYF 112
D + ++++ ALY+YQ +S E++ KGD + N DW++ + ++G VP Y
Sbjct: 964 DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE--VNDRQGFVPAAYV 1021
Query: 113 EIFGRTRPNSHASPVKSINRNGSV 136
+ + P AS + GS+
Sbjct: 1022 K---KLDPAQSASRENLLEEQGSI 1042
>Hs4502413 [T] KOG0197 Tyrosine kinases
Length = 505
Score = 37.7 bits (86), Expect = 0.047
Identities = 17/50 (34%), Positives = 27/50 (54%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNY 111
+ ALY+Y A + +L KG+ V + DW+ A + G+ G VP N+
Sbjct: 63 VVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNF 112
>Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 475
Score = 37.7 bits (86), Expect = 0.047
Identities = 22/56 (39%), Positives = 32/56 (56%), Gaps = 4/56 (7%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFE 113
EKV+ A+Y+Y ELSF +G +V ++ +D WYE +G G+ P NY E
Sbjct: 416 EKVV-AIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYE--GVMNGVTGLFPGNYVE 468
>Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 946
Score = 37.7 bits (86), Expect = 0.047
Identities = 19/73 (26%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNS 122
A + Y ++A ELSF +GD + ++ +DW+ + +G RG++P Y + T
Sbjct: 753 ACFAYTGRTAQELSFRRGDVLRLHERASSDWWRGEH--NGMRGLIPHKYITLPAGTEKQV 810
Query: 123 HASPVKSINRNGS 135
+ +++ +GS
Sbjct: 811 VGAGLQTAGESGS 823
>7299844 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 473
Score = 37.7 bits (86), Expect = 0.047
Identities = 22/56 (39%), Positives = 32/56 (56%), Gaps = 4/56 (7%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFE 113
EKV+ A+Y+Y A ELSF + +V ++ +D W+E DG G+ P NY E
Sbjct: 418 EKVV-AIYDYYADKDDELSFQESSVLYVLKKNDDGWWE--GVMDGVTGLFPGNYVE 470
>SPBC1734.08 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 373
Score = 37.4 bits (85), Expect = 0.062
Identities = 20/53 (37%), Positives = 29/53 (53%), Gaps = 3/53 (5%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFE 113
++ALY++ A GELSF KGD V + DW++ S G+ P NY +
Sbjct: 220 VRALYDFAATEQGELSFKKGDIILVLESVYKDWWKGS--CKNAVGIFPVNYVQ 270
>Hs9507221 [G] KOG3734 Predicted phosphoglycerate mutase
Length = 661
Score = 37.4 bits (85), Expect = 0.062
Identities = 17/57 (29%), Positives = 30/57 (51%), Gaps = 5/57 (8%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-----WYEASNPADGKRGMVPKNY 111
+ ++AL+ Y+ Q+ EL+ + GD+ V + D W + G RG +P+NY
Sbjct: 279 QTLRALFQYKPQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFLPENY 335
>Hs7661700 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 816
Score = 37.4 bits (85), Expect = 0.062
Identities = 29/141 (20%), Positives = 54/141 (37%), Gaps = 7/141 (4%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNS 122
A +N+ + E+SF KG+ + +Q + +WYE P ++G+ P Y ++ R +
Sbjct: 656 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 715
Query: 123 HAS----PVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADE 178
P S + S ++ + A LY + + DE
Sbjct: 716 PVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQA--LYSYIPQNDDE 773
Query: 179 LTAYAGENLFICAHHDFEWFI 199
L G+ + + D WF+
Sbjct: 774 LELRDGDIVDVMEKCDDGWFV 794
Score = 30.4 bits (67), Expect = 7.5
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNY 111
+ALY+Y Q+ EL GD V ++ +D W+ ++ + G P NY
Sbjct: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNY 810
>Hs5454056 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 684
Score = 37.4 bits (85), Expect = 0.062
Identities = 29/141 (20%), Positives = 54/141 (37%), Gaps = 7/141 (4%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNS 122
A +N+ + E+SF KG+ + +Q + +WYE P ++G+ P Y ++ R +
Sbjct: 524 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 583
Query: 123 HAS----PVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADE 178
P S + S ++ + A LY + + DE
Sbjct: 584 PVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQA--LYSYIPQNDDE 641
Query: 179 LTAYAGENLFICAHHDFEWFI 199
L G+ + + D WF+
Sbjct: 642 LELRDGDIVDVMEKCDDGWFV 662
Score = 30.4 bits (67), Expect = 7.5
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNY 111
+ALY+Y Q+ EL GD V ++ +D W+ ++ + G P NY
Sbjct: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNY 678
>Hs4758476 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 330
Score = 37.4 bits (85), Expect = 0.062
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 2/51 (3%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEI 114
A +++ A ELSF+ GD + + +W++A + G VPKN+ +I
Sbjct: 5 AKFDFTASGEDELSFHTGDVLKILSNQEEWFKAE--LGSQEGYVPKNFIDI 53
>YCR088w [Z] KOG3655 Drebrins and related actin binding proteins
Length = 592
Score = 37.0 bits (84), Expect = 0.080
Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 7/66 (10%)
Query: 56 SSPEKVIK------ALYNYQAQSAGELSFNKGD-FFHVQQEENDWYEASNPADGKRGMVP 108
++PEK K A Y+Y A EL+F + D +++ ++DW+ DG +G+ P
Sbjct: 525 ATPEKKPKENPWATAEYDYDAAEDNELTFVENDKIINIEFVDDDWWLGELEKDGSKGLFP 584
Query: 109 KNYFEI 114
NY +
Sbjct: 585 SNYVSL 590
>SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 296
Score = 37.0 bits (84), Expect = 0.080
Identities = 17/54 (31%), Positives = 29/54 (53%), Gaps = 3/54 (5%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEI 114
+ A+Y++ AG+L F+ G+ V + NDW+ +GK G+ P NY +
Sbjct: 145 VLAMYDFPGPDAGDLGFHAGEVIIVLEHVNNDWWRGE--LNGKEGIFPSNYVRL 196
>Hs14777594 [TZ] KOG3632 Peripheral benzodiazepine receptor PRAX-1
Length = 1545
Score = 37.0 bits (84), Expect = 0.080
Identities = 21/62 (33%), Positives = 31/62 (49%), Gaps = 9/62 (14%)
Query: 60 KVIKALYNYQA------QSAGELSFNKGDFFHV--QQEENDWYEASNPADGKRGMVPKNY 111
K+ A YNY GEL GD+ ++ +E+ +YE DG+RG+VP N+
Sbjct: 741 KIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELD-DGRRGLVPSNF 799
Query: 112 FE 113
E
Sbjct: 800 VE 801
>Hs14777578 [TZ] KOG3632 Peripheral benzodiazepine receptor PRAX-1
Length = 1545
Score = 37.0 bits (84), Expect = 0.080
Identities = 21/62 (33%), Positives = 31/62 (49%), Gaps = 9/62 (14%)
Query: 60 KVIKALYNYQA------QSAGELSFNKGDFFHV--QQEENDWYEASNPADGKRGMVPKNY 111
K+ A YNY GEL GD+ ++ +E+ +YE DG+RG+VP N+
Sbjct: 741 KIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELD-DGRRGLVPSNF 799
Query: 112 FE 113
E
Sbjct: 800 VE 801
>CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 449
Score = 37.0 bits (84), Expect = 0.080
Identities = 18/55 (32%), Positives = 32/55 (57%), Gaps = 3/55 (5%)
Query: 58 PEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNY 111
PEK ++ALY+++A + ELSF GD + E N W+ + ++G+ P ++
Sbjct: 212 PEKNVRALYDFEAAESNELSFVAGDIITITDESNPHWW--TGRIGTQQGLFPSSF 264
>7291268 [D] KOG0515 p53-interacting protein 53BP/ASPP contains ankyrin and
SH3 domains
Length = 1071
Score = 37.0 bits (84), Expect = 0.080
Identities = 20/53 (37%), Positives = 34/53 (63%), Gaps = 5/53 (9%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQE----ENDWYEASNPADGKRGMVPKN 110
+ A+++Y+AQ+ ELSF+ + V ++ EN+W+ A N A G+ G VP+N
Sbjct: 1001 VYAVFSYEAQNGDELSFHVNEPLIVLRKGDDAENEWWWARNAA-GEEGYVPRN 1052
>Hs4885643 [D] KOG0515 p53-interacting protein 53BP/ASPP contains ankyrin and
SH3 domains
Length = 1005
Score = 36.6 bits (83), Expect = 0.10
Identities = 20/68 (29%), Positives = 36/68 (52%), Gaps = 6/68 (8%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV----QQEENDWYEASNPADGKRGMVPKNYFEIFG 116
VI AL++Y+ Q+ EL +GD + ++E +W+ A + K G VP+N ++
Sbjct: 938 VIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWAR--LNDKEGYVPRNLLGLYP 995
Query: 117 RTRPNSHA 124
R +P +
Sbjct: 996 RIKPRQRS 1003
>CE16651 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 408
Score = 36.6 bits (83), Expect = 0.10
Identities = 18/57 (31%), Positives = 30/57 (52%), Gaps = 1/57 (1%)
Query: 58 PEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEI 114
P A+Y ++ +SA EL N+GD + +E D Y +G+ G+ P +Y +I
Sbjct: 87 PVMTATAVYKFEPRSARELPLNRGDIIRIIREV-DGYWMEGERNGRSGIFPTSYVQI 142
Score = 32.0 bits (71), Expect = 2.6
Identities = 18/53 (33%), Positives = 31/53 (57%), Gaps = 2/53 (3%)
Query: 62 IKALYNYQAQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGMVPKNYFE 113
++A+Y + A+S ELS +G+ +Q +++W E SN G G+ P +Y E
Sbjct: 153 MRAIYPFTARSDTELSLKRGEIITRRRQIDSNWLEGSNQI-GIVGIFPASYVE 204
Score = 31.6 bits (70), Expect = 3.4
Identities = 17/58 (29%), Positives = 29/58 (49%), Gaps = 1/58 (1%)
Query: 55 ISSPEKVIKALYNYQAQSAGELSFNKGD-FFHVQQEENDWYEASNPADGKRGMVPKNY 111
I ++ +A+Y YQ Q EL D F V++ ++ W+ ++ G G+ P NY
Sbjct: 347 IPKGSEMYRAVYPYQPQKEDELQLYTNDIIFVVEKCDDGWFIGTSLRTGDFGIFPGNY 404
Score = 30.0 bits (66), Expect = 9.8
Identities = 12/32 (37%), Positives = 18/32 (55%)
Query: 168 LYDFQAEKADELTAYAGENLFICAHHDFEWFI 199
+Y +Q +K DEL Y + +F+ D WFI
Sbjct: 357 VYPYQPQKEDELQLYTNDIIFVVEKCDDGWFI 388
>7298672 [F] KOG2070 Guanine nucleotide exchange factor
Length = 687
Score = 36.6 bits (83), Expect = 0.10
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 3/52 (5%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNY 111
V++A Y++ + EL F KGD V Q+E+ W+E + + K G P NY
Sbjct: 6 VVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGT--LNDKTGWFPSNY 55
>7290878 [TZ] KOG4035 Coeffector of mDia Rho GTPase regulates actin
polymerization and cell adhesion turnover
Length = 801
Score = 36.6 bits (83), Expect = 0.10
Identities = 18/54 (33%), Positives = 33/54 (60%), Gaps = 4/54 (7%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHVQQ---EENDWYEASNPADGKRGMVPKNY 111
++KALY++QA +SF++G++F + Q + +W++ + G G VP NY
Sbjct: 1 MLKALYDFQAVYPKTISFDEGEYFILYQTSARQRNWWQVVS-MKGNIGFVPSNY 53
>SPBC12C2.05c [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 642
Score = 36.2 bits (82), Expect = 0.14
Identities = 22/52 (42%), Positives = 25/52 (47%), Gaps = 4/52 (7%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEE--NDWYEASNPADGKRGMVPKNY 111
+KALY Y AQS ELS +GD V N W E +G G P NY
Sbjct: 589 VKALYAYTAQSDMELSIQEGDIIQVTNRNAGNGWSEGI--LNGVTGQFPANY 638
>Hs4506071 [T] KOG0695 Serine/threonine protein kinase
Length = 587
Score = 36.2 bits (82), Expect = 0.14
Identities = 18/59 (30%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 497 VKIKFYYKDDIFALMLHPTITFEELCSKIAPRIDADSFKLY-IKNGDDIGTQVTTDAEV 554
V++K YY+ DI P+I+FE LC+++ D+ +L+ +K D+ G T +++
Sbjct: 17 VRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQL 75
>CE28360 [T] KOG4792 Crk family adapters
Length = 279
Score = 36.2 bits (82), Expect = 0.14
Identities = 25/79 (31%), Positives = 40/79 (49%), Gaps = 6/79 (7%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNYFEI---F 115
+V+ + + + +L F +G+ + + N DW+EA N A G G+VP NY +I F
Sbjct: 119 EVVVGTFKFTGERETDLPFEQGERLEILSKTNQDWWEARN-ALGTTGLVPANYVQIQMEF 177
Query: 116 GRTRPNSHASPVKSINRNG 134
R + AS SI +G
Sbjct: 178 HNDRTSKGASQ-SSIGSSG 195
>HsM7661718 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 430
Score = 35.8 bits (81), Expect = 0.18
Identities = 19/53 (35%), Positives = 29/53 (53%), Gaps = 2/53 (3%)
Query: 63 KALYNYQAQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGMVPKNYFEI 114
+ALY+YQA E+SF+ + ++ + W+ P DG GM P NY E+
Sbjct: 377 RALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGP-DGHFGMFPANYVEL 428
>Hs4502249 [T] KOG0521 Putative GTPase activating proteins (GAPs)
Length = 1006
Score = 35.8 bits (81), Expect = 0.18
Identities = 19/54 (35%), Positives = 32/54 (59%), Gaps = 2/54 (3%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQ-QEENDWYEASNPAD-GKRGMVPKNY 111
K +KALYN A + EL+F++GD V +E+ +W+ D G++G P ++
Sbjct: 947 KRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSF 1000
>Hs21361670 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 431
Score = 35.8 bits (81), Expect = 0.18
Identities = 19/53 (35%), Positives = 29/53 (53%), Gaps = 2/53 (3%)
Query: 63 KALYNYQAQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGMVPKNYFEI 114
+ALY+YQA E+SF+ + ++ + W+ P DG GM P NY E+
Sbjct: 378 RALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGP-DGHFGMFPANYVEL 429
>SPCC1223.04c [R] KOG1337 N-methyltransferase
Length = 381
Score = 35.4 bits (80), Expect = 0.23
Identities = 23/75 (30%), Positives = 36/75 (47%), Gaps = 11/75 (14%)
Query: 307 FLTYAAVETFFLQDDKYWFQVSCQLSNNTTRILKRYYEDFYDLQVKLLDIFPAEGGKLRD 366
F+ + + FLQD YW +C L + R L + V+ L + P+E KL D
Sbjct: 252 FIEFDKWQQSFLQDHGYWNDYTCSLHGASFRTL---------VGVRTLLVSPSE--KLND 300
Query: 367 TNGQWTKRIMPYIPG 381
+ T+R++ YI G
Sbjct: 301 ASYDQTRRVLQYING 315
>Hs4505723 [U] KOG3875 Peroxisomal biogenesis protein peroxin
Length = 403
Score = 35.4 bits (80), Expect = 0.23
Identities = 22/65 (33%), Positives = 35/65 (53%), Gaps = 8/65 (12%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHVQQEEND-----WYEASNPADGK-RGMVPKNYFEI 114
V +A Y++ A S E+SF GD ++ +E W AS DG+ G++P NY +I
Sbjct: 276 VARAEYDFAAVSEEEISFRAGDMLNLALKEQQPKVRGWLLAS--LDGQTTGLIPANYVKI 333
Query: 115 FGRTR 119
G+ +
Sbjct: 334 LGKRK 338
>Hs22051526 [Z] KOG0162 Myosin class I heavy chain
Length = 1077
Score = 35.4 bits (80), Expect = 0.23
Identities = 18/52 (34%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQEE-NDWYEASNPADGKRGMVPKNYFE 113
+ALY Y Q ELSFN + + E+ + W++ G+ G+ P NY E
Sbjct: 1026 RALYQYVGQDVDELSFNVNEVIEILMEDPSGWWKGR--LHGQEGLFPGNYVE 1075
>Hs20555436 [TUZ] KOG2856 Adaptor protein PACSIN
Length = 444
Score = 35.4 bits (80), Expect = 0.23
Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPAD-GKRGMVPKNYFE 113
++ALY+Y Q ELSF GD EE++ D G+ G+ P NY E
Sbjct: 390 VRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 442
>CE19084 [S] KOG2995 FOG: SH3 domain
Length = 728
Score = 35.4 bits (80), Expect = 0.23
Identities = 29/140 (20%), Positives = 61/140 (42%), Gaps = 24/140 (17%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFEIFGRTRPN 121
+A+Y++Q + ELSF+ + +++ + +W E S + G+ P ++ +I P+
Sbjct: 413 RAVYDFQGEFENELSFSADEIISLRRRIDAEWLEGSI-GSARVGIFPTSFVQIIVDL-PD 470
Query: 122 SHASPVKSINRNGSVGSNXXXXXXXXXXXXXXXXXPSNMGTLYAIVLYDFQAEKADELTA 181
+ +++ R+ + N G +A V + F + DELT
Sbjct: 471 DDTTSLQNNRRSTTT---------------------ENDGIGFANVRHAFSGRQGDELTV 509
Query: 182 YAGENLFICAHHDFEWFIAK 201
AG+ + + + EW + K
Sbjct: 510 NAGDTVRVLRMVNDEWVMCK 529
Score = 31.6 bits (70), Expect = 3.4
Identities = 15/49 (30%), Positives = 24/49 (48%), Gaps = 1/49 (2%)
Query: 68 YQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFEIF 115
+ + EL+ N GD V + ND W +P K G+VP + E++
Sbjct: 499 FSGRQGDELTVNAGDTVRVLRMVNDEWVMCKDPDTEKTGIVPVGFLEVY 547
>CE18868 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 643
Score = 35.4 bits (80), Expect = 0.23
Identities = 18/57 (31%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGMVPKNYFEI 114
E+ AL++YQA E+SF+ D + Q ++ W++ P+ G+ G+ P NY ++
Sbjct: 587 EQNAMALWDYQAADDTEISFDPDDIITDIDQVDSGWWKGRAPS-GRVGLFPANYVKL 642
>YHR114w [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 633
Score = 35.0 bits (79), Expect = 0.31
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 58 PEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNY 111
P + ++A+Y Y+AQ E+S + GD V + ++ DG +G+ P +Y
Sbjct: 578 PVRTMEAIYAYEAQGDDEISIDPGDIITVIRGDDGSGWTYGECDGLKGLFPTSY 631
Score = 32.0 bits (71), Expect = 2.6
Identities = 22/79 (27%), Positives = 36/79 (44%), Gaps = 9/79 (11%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEE--NDWYEASNPADGKRGMVPKNYFE 113
SS + K LY Y + E++ GD + + + W + +N G+ G+VP Y
Sbjct: 492 SSDDGKNKVLYAYVQKDDDEITITPGDKISLVARDTGSGWTKINNDTTGETGLVPTTYIR 551
Query: 114 IFGRTRPNSHASPVKSINR 132
I S A+ VK+ +R
Sbjct: 552 I-------SSAATVKANDR 563
>YHL002w [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 452
Score = 35.0 bits (79), Expect = 0.31
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 3/51 (5%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNY 111
++ALY+ ELSF KGD V +Q DW++ + G G+ P NY
Sbjct: 222 VRALYDLTTNEPDELSFRKGDVITVLEQVYRDWWKGA--LRGNMGIFPLNY 270
>Hs7661670 [S] KOG1843 Uncharacterized conserved protein
Length = 246
Score = 35.0 bits (79), Expect = 0.31
Identities = 18/53 (33%), Positives = 29/53 (53%), Gaps = 5/53 (9%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEN---DWYEASNPADGKRGMVPKNY 111
+ ALY+++ Q G+L+F GD V + + DW+E G+ G+ P NY
Sbjct: 192 VTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGK--LRGQTGIFPANY 242
>Hs4885633 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 519
Score = 35.0 bits (79), Expect = 0.31
Identities = 23/78 (29%), Positives = 37/78 (46%), Gaps = 5/78 (6%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFEI 114
+SP+ ++ L Y+ + EL+ K D V Q+ +D W E +DG+RG P E
Sbjct: 433 NSPQ--VQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEF 490
Query: 115 FGRTRPNSHASPVKSINR 132
+ P A +K +R
Sbjct: 491 I--SNPEVRAQNLKEAHR 506
>CE29545 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 469
Score = 35.0 bits (79), Expect = 0.31
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 3/51 (5%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNY 111
++ LY+Y A EL+ + +V ++ ++DWYE DG G+ P NY
Sbjct: 417 VRVLYDYDAAKEDELTLRENAIVYVLKKNDDDWYE--GVLDGVTGLFPGNY 465
Score = 30.4 bits (67), Expect = 7.5
Identities = 12/32 (37%), Positives = 19/32 (58%)
Query: 167 VLYDFQAEKADELTAYAGENLFICAHHDFEWF 198
VLYD+ A K DELT +++ +D +W+
Sbjct: 419 VLYDYDAAKEDELTLRENAIVYVLKKNDDDWY 450
>7292157 [Z] KOG0040 Ca2+-binding actin-bundling protein (spectrin) alpha
chain (EF-Hand protein superfamily)
Length = 2415
Score = 35.0 bits (79), Expect = 0.31
Identities = 21/61 (34%), Positives = 33/61 (53%), Gaps = 4/61 (6%)
Query: 54 DISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNYF 112
DI+ E V+ ALY+Y +S E+S KGD + N DW++ + ++G VP Y
Sbjct: 968 DITGKECVV-ALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVE--VNDRQGFVPAAYI 1024
Query: 113 E 113
+
Sbjct: 1025 K 1025
>SPBC11C11.02 [D] KOG2398 Predicted proline-serine-threonine
phosphatase-interacting protein (PSTPIP)
Length = 670
Score = 34.7 bits (78), Expect = 0.40
Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 3/53 (5%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYE--ASNPADGKRGMVPKNY 111
+ ALY+Y A E+SF KGD V + E+ W+E D RG P N+
Sbjct: 612 VSALYDYDAAIPEEISFRKGDTIAVLKLYEDGWWEGFVVGEDDHNRGQFPSNF 664
>SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein
Length = 430
Score = 34.7 bits (78), Expect = 0.40
Identities = 26/114 (22%), Positives = 51/114 (43%), Gaps = 14/114 (12%)
Query: 4 DSVKQRITSADISGPTQSPGSSVQNVKTIPIRXXXXXXXXXXXXXXXXXKDISSPEKVIK 63
D ++ + S+D+S + S SS + + P R +D P + +
Sbjct: 327 DEDEESVYSSDVSTESSSQFSSRSSEYSKPSRPTAPKPKFK--------QDSLGPNQA-R 377
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQ---EENDWYEASNPADGKRGMVPKNYFEI 114
A+Y++ + G+LSF KGD + + +DW+ + + G+ P NY ++
Sbjct: 378 AMYSFAGEQPGDLSFQKGDIIDIVERSGSHDDWW--TGRIGYREGIFPANYVKL 429
>Hs22046517 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 802
Score = 34.7 bits (78), Expect = 0.40
Identities = 18/53 (33%), Positives = 28/53 (51%), Gaps = 1/53 (1%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFE 113
++ + Y+A EL+ K D V+ +D W E ADG++G VP+ Y E
Sbjct: 720 VQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVE 772
>Hs20545357 [T] KOG0583 Serine/threonine protein kinase
Length = 436
Score = 34.7 bits (78), Expect = 0.40
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 24/117 (20%)
Query: 371 WTKRIMPY--IPGPVPYVTDTISKKRKDDLNIYVKDLISLPPHISQS--HLVKGLFA--- 423
W ++ Y + G +P+ +T++K +K L + S+PPH+S+ L++G+
Sbjct: 255 WALGVLLYFMVTGTMPFRAETVAKLKKSIL----EGTYSVPPHVSEPCHRLIRGVLQQIP 310
Query: 424 VKNNGFDREISNDETVE------------LDVKGRADDSTLTNQELQLPEAMKRLSL 468
+ G D I NDE ++ LD K ++ STL +E ++ ++ L +
Sbjct: 311 TERYGIDC-IMNDEWMQGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGI 366
>Hs16418371 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 628
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/60 (26%), Positives = 34/60 (56%), Gaps = 3/60 (5%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHV--QQEENDWYEASNPADGKRGMVPKNYFEIFGRTRP 120
+ALY++++++ GE+S + + + +Q+ W E N + G RG+ P +Y ++ P
Sbjct: 6 RALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVN-SRGDRGLFPASYVQVIRAPEP 64
>CE07373 [Z] KOG0040 Ca2+-binding actin-bundling protein (spectrin) alpha
chain (EF-Hand protein superfamily)
Length = 2427
Score = 34.7 bits (78), Expect = 0.40
Identities = 20/64 (31%), Positives = 31/64 (48%), Gaps = 3/64 (4%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNYFEIFGRTRP 120
+ ALY+YQ +S E+S KGD + N DW++ + ++G VP Y +
Sbjct: 988 VLALYDYQEKSPREVSMKKGDVLTLLNASNRDWWKVE--VNDRQGFVPAAYVKRIEPGTA 1045
Query: 121 NSHA 124
HA
Sbjct: 1046 QQHA 1049
>7303429 [U] KOG3771 Amphiphysin
Length = 602
Score = 34.7 bits (78), Expect = 0.40
Identities = 16/56 (28%), Positives = 24/56 (42%), Gaps = 6/56 (10%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHV------QQEENDWYEASNPADGKRGMVPKNY 111
+KA Y Y + ELSF GD V + +E W ++G+ P N+
Sbjct: 543 VKATYGYAKEDVDELSFEIGDLIRVIEYDDPEDQEEGWLMGQKEGTNEKGLFPANF 598
>CE18886_2 [F] KOG2070 Guanine nucleotide exchange factor
Length = 655
Score = 34.7 bits (78), Expect = 0.40
Identities = 22/77 (28%), Positives = 38/77 (48%), Gaps = 11/77 (14%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNYFEIF------ 115
+A + ++ + ELSF+K D + QQ+E W+E ++ +G G P Y +
Sbjct: 21 RAKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTH--EGVTGWFPCAYVTLITEKDKL 78
Query: 116 --GRTRPNSHASPVKSI 130
R+ PN+ A V S+
Sbjct: 79 QRSRSVPNATAKEVVSV 95
>SPBC19C2.10 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 501
Score = 34.3 bits (77), Expect = 0.52
Identities = 18/61 (29%), Positives = 29/61 (47%), Gaps = 6/61 (9%)
Query: 57 SPEKVIKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPAD-----GKRGMVPKN 110
S KV++ Y+++ ++ EL KGD V +E + W+ + G GM P N
Sbjct: 421 SSRKVVRMKYSFEPETENELKLKKGDLLLVLKEIDEGWWVGEKLGEDGVFTGNTGMFPSN 480
Query: 111 Y 111
Y
Sbjct: 481 Y 481
>Hs22047742 [T] KOG0521 Putative GTPase activating proteins (GAPs)
Length = 652
Score = 34.3 bits (77), Expect = 0.52
Identities = 18/53 (33%), Positives = 25/53 (46%)
Query: 168 LYDFQAEKADELTAYAGENLFICAHHDFEWFIAKPIGRXXXXXXXXXXFVTII 220
+YD QA+ DELT GE + + D EW+I G+ FV I+
Sbjct: 598 IYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHIL 650
>Hs22040999 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 918
Score = 34.3 bits (77), Expect = 0.52
Identities = 26/104 (25%), Positives = 44/104 (42%), Gaps = 6/104 (5%)
Query: 14 DISGPTQSPGSSVQNVKTIPIRXXXXXXXXXXXXXXX--XXKDISSPEKVIKALYNYQAQ 71
++ GP S G S+++ P D P + I A ++Y +
Sbjct: 531 ELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAI-AKFDYVGR 589
Query: 72 SAGELSFNKG-DFFHVQQEENDWYEASNPADGKRGMVPKNYFEI 114
+A ELSF KG Q+ +DW+E + +G G++P Y +
Sbjct: 590 TARELSFKKGASLLLYQRASDDWWEGRH--NGIDGLIPHQYIVV 631
>Hs20546502 [T] KOG1998 Signaling protein DOCK180
Length = 1830
Score = 34.3 bits (77), Expect = 0.52
Identities = 17/52 (32%), Positives = 26/52 (49%), Gaps = 1/52 (1%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGK-RGMVPKNYFEI 114
A+YN+Q A +LS GD +Q+ DWY +G+ PK++ I
Sbjct: 15 AIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHI 66
>7302755_2 [S] KOG2995 FOG: SH3 domain
Length = 701
Score = 34.3 bits (77), Expect = 0.52
Identities = 16/52 (30%), Positives = 30/52 (56%), Gaps = 3/52 (5%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNYFEI 114
AL+++ + A +L F KGD ++ +N+W+ A+G+ G P NY ++
Sbjct: 5 ALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQ--ANGQEGTFPINYVKV 54
Score = 33.5 bits (75), Expect = 0.89
Identities = 16/56 (28%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQ-QEENDWYEASNPADGKRGMVPKNYFE 113
E + + Y S EL + GD +VQ +++N WY+ ++ K G+ P ++ E
Sbjct: 643 ESRFRCIVPYPPNSDIELELHLGDIIYVQRKQKNGWYKGTHARTHKTGLFPASFVE 698
>YPR154w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 215
Score = 33.9 bits (76), Expect = 0.68
Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 3/51 (5%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNY 111
++ALY + Q G+L GD + ++ +WY+ S +G+ G+ P NY
Sbjct: 59 VEALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKGS--CNGRTGIFPANY 107
>Hs4885611 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 508
Score = 33.9 bits (76), Expect = 0.68
Identities = 21/56 (37%), Positives = 31/56 (54%), Gaps = 4/56 (7%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNYFE 113
EKV+ A+Y+Y ELSF +G +V ++ +D WYE + G+ P NY E
Sbjct: 449 EKVV-AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYE--GVCNRVTGLFPGNYVE 501
>Hs21361641 [R] KOG0266 WD40 repeat-containing protein
Length = 1196
Score = 33.9 bits (76), Expect = 0.68
Identities = 18/51 (35%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNY 111
+ ALY+Y A + EL+ ++GD V ++N DW+ S G+ G P N+
Sbjct: 1056 VVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGS-IGKGQEGYFPANH 1105
>CE19874 [D] KOG0515 p53-interacting protein 53BP/ASPP contains ankyrin and
SH3 domains
Length = 769
Score = 33.9 bits (76), Expect = 0.68
Identities = 17/57 (29%), Positives = 31/57 (53%), Gaps = 4/57 (7%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQE---ENDWYEASNPADGKRGMVPKNYFEIF 115
+ A Y Y+A ELSF+ GD V ++ + +W+ +G++G VP+ Y ++
Sbjct: 689 VYAAYGYEAAFEDELSFDAGDELTVIEKDKVDKNWWTCEK-NNGEKGQVPRTYLALY 744
>7297777 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 689
Score = 33.9 bits (76), Expect = 0.68
Identities = 18/55 (32%), Positives = 31/55 (55%), Gaps = 4/55 (7%)
Query: 58 PEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNY 111
P KV +ALY+++A EL+F G+ HV + + +W++ N G+ P N+
Sbjct: 234 PRKV-RALYDFEAAEENELTFFAGEIIHVLDDSDPNWWKGYNQRG--EGLFPSNF 285
Score = 31.2 bits (69), Expect = 4.4
Identities = 13/31 (41%), Positives = 20/31 (63%)
Query: 168 LYDFQAEKADELTAYAGENLFICAHHDFEWF 198
LYDF+A + +ELT +AGE + + D W+
Sbjct: 240 LYDFEAAEENELTFFAGEIIHVLDDSDPNWW 270
>Hs4557787 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 526
Score = 33.5 bits (75), Expect = 0.89
Identities = 18/53 (33%), Positives = 29/53 (53%), Gaps = 3/53 (5%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNYFE 113
++AL++Y+A +L F +GD V + N +W E GK G+ PK + E
Sbjct: 462 VEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGE--CKGKVGIFPKVFVE 512
Score = 30.8 bits (68), Expect = 5.8
Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 6/73 (8%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFE-----IFGR 117
+ L+ + ++ EL G+ V ++ ND + A+ +G++G+VP NY E I +
Sbjct: 246 RVLFGFVPETKEELQVMPGNIVFVLKKGNDNW-ATVMFNGQKGLVPCNYLEPVELRIHPQ 304
Query: 118 TRPNSHASPVKSI 130
+P +SP I
Sbjct: 305 QQPQEESSPQSDI 317
>Hs4507189 [Z] KOG0040 Ca2+-binding actin-bundling protein (spectrin) alpha
chain (EF-Hand protein superfamily)
Length = 2429
Score = 33.5 bits (75), Expect = 0.89
Identities = 19/54 (35%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWYEASNPADGKRGMVPKNY 111
E+ + ALY++QA+S E++ KGD + N DW++ A +G+VP Y
Sbjct: 979 EQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVE--AADHQGIVPAVY 1030
>Hs21071018 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 594
Score = 33.5 bits (75), Expect = 0.89
Identities = 16/58 (27%), Positives = 29/58 (49%), Gaps = 1/58 (1%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
+ P ++ LY ++A++ EL+ +G+ V W+ N A G+ G +P N E
Sbjct: 450 AQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEA-GRSGYIPSNILE 506
Score = 32.3 bits (72), Expect = 2.0
Identities = 15/39 (38%), Positives = 19/39 (48%)
Query: 167 VLYDFQAEKADELTAYAGENLFICAHHDFEWFIAKPIGR 205
VLY+F+A ELT GE L + H W + GR
Sbjct: 458 VLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGR 496
>Hs21071016 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 593
Score = 33.5 bits (75), Expect = 0.89
Identities = 16/58 (27%), Positives = 29/58 (49%), Gaps = 1/58 (1%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
+ P ++ LY ++A++ EL+ +G+ V W+ N A G+ G +P N E
Sbjct: 449 AQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEA-GRSGYIPSNILE 505
Score = 32.3 bits (72), Expect = 2.0
Identities = 15/39 (38%), Positives = 19/39 (48%)
Query: 167 VLYDFQAEKADELTAYAGENLFICAHHDFEWFIAKPIGR 205
VLY+F+A ELT GE L + H W + GR
Sbjct: 457 VLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGR 495
>Hs21071014 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 563
Score = 33.5 bits (75), Expect = 0.89
Identities = 16/58 (27%), Positives = 29/58 (49%), Gaps = 1/58 (1%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
+ P ++ LY ++A++ EL+ +G+ V W+ N A G+ G +P N E
Sbjct: 419 AQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEA-GRSGYIPSNILE 475
Score = 32.3 bits (72), Expect = 2.0
Identities = 15/39 (38%), Positives = 19/39 (48%)
Query: 167 VLYDFQAEKADELTAYAGENLFICAHHDFEWFIAKPIGR 205
VLY+F+A ELT GE L + H W + GR
Sbjct: 427 VLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGR 465
>Hs15451926 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1634
Score = 33.5 bits (75), Expect = 0.89
Identities = 27/116 (23%), Positives = 52/116 (44%), Gaps = 24/116 (20%)
Query: 314 ETFFLQDDKYWFQVSCQLSN-NTTRILKRYYEDFYDLQVKLLDIFPAEGGKLRDTNGQWT 372
E F + Y + V N + ++R +E+F +L KL +FP+
Sbjct: 1376 EKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSS------------ 1423
Query: 373 KRIMPYIPG-PVPYVT-----DTISKKRKDDLNIYVKDLISLPPHISQSHLVKGLF 422
++P P +V + ++++R+++LN Y+ LI PP +++ LV F
Sbjct: 1424 -----HLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFF 1474
>SPCC1919.11 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 420
Score = 33.1 bits (74), Expect = 1.2
Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 6/56 (10%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEN-DWY---EASNPAD--GKRGMVPKNY 111
+KA+Y++ ++ EL + GD V ++ DWY + ++ A+ G GM P NY
Sbjct: 284 VKAIYSFTGRNEKELDLHTGDVIQVSEQLGPDWYMGEKVNSKAEKLGNSGMFPVNY 339
>SPBC146.13c [Z] KOG0162 Myosin class I heavy chain
Length = 1217
Score = 33.1 bits (74), Expect = 1.2
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 16/87 (18%)
Query: 64 ALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRP-- 120
ALY++ +S E++ K + VQ+E + W+ A +G G VP Y + + P
Sbjct: 1113 ALYDFAGRSPNEMTIKKDEIIEIVQKEPSGWWLALK--NGAEGWVPATYVTEYKGSTPQT 1170
Query: 121 -----------NSHASPVKSINRNGSV 136
N++ASP + N GS+
Sbjct: 1171 TASSTNVAAQANNNASPAEVNNLAGSL 1197
>Hs4507429 [T] KOG0197 Tyrosine kinases
Length = 631
Score = 33.1 bits (74), Expect = 1.2
Identities = 14/54 (25%), Positives = 31/54 (56%), Gaps = 2/54 (3%)
Query: 59 EKVIKALYNYQAQSAGELSFNKG-DFFHVQQEENDWYEASNPADGKRGMVPKNY 111
E+++ A+Y++QA +L +G ++ +++ + W+ A + G G +P NY
Sbjct: 181 EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKY-GNEGYIPSNY 233
>7294076 [T] KOG4278 Protein tyrosine kinase
Length = 1504
Score = 33.1 bits (74), Expect = 1.2
Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 3/50 (6%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHV--QQEENDWYEASNPADGKRGMVPKNY 111
ALY++QA +LS KG+ + + +W EA + + G G VP NY
Sbjct: 194 ALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDS-GNVGWVPSNY 242
>Hs4505869 [I] KOG1264 Phospholipase C
Length = 1290
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/54 (35%), Positives = 31/54 (57%), Gaps = 4/54 (7%)
Query: 62 IKALYNYQAQSAGELSFNKGDFF-HVQQEENDWYEASNPADGKRGM-VPKNYFE 113
+KAL++Y+AQ EL+F K +V+++E W+ GK+ + P NY E
Sbjct: 796 VKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGD--YGGKKQLWFPSNYVE 847
>Hs16158568 [T] KOG4637 Adaptor for phosphoinositide 3-kinase
Length = 724
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/73 (26%), Positives = 29/73 (39%), Gaps = 16/73 (21%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQ----------------EENDWYEASNPADGKRGM 106
+ALY+Y+ + ++ + GD V + EE W N G+RG
Sbjct: 9 RALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGD 68
Query: 107 VPKNYFEIFGRTR 119
P Y E GR +
Sbjct: 69 FPGTYVEYIGRKK 81
>CE25256 [TZ] KOG3632 Peripheral benzodiazepine receptor PRAX-1
Length = 1347
Score = 32.7 bits (73), Expect = 1.5
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 8/62 (12%)
Query: 60 KVIKALYNY-------QAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMVPKNY 111
+V +AL+ Y ELS GD V+ E ++D + DG++G+VP NY
Sbjct: 41 RVFRALFQYLPLRDSPNENPQLELSLQPGDVVLVKGEMDSDGFYCGETLDGRQGLVPSNY 100
Query: 112 FE 113
E
Sbjct: 101 VE 102
>CE22093 [T] KOG0197 Tyrosine kinases
Length = 662
Score = 32.7 bits (73), Expect = 1.5
Identities = 20/77 (25%), Positives = 41/77 (52%), Gaps = 3/77 (3%)
Query: 56 SSPEKVIKALYN-YQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYFE 113
S PE+ + + N + AQ+ E+S +GD + ++Q +W+ ++ + +G VPK++
Sbjct: 180 SEPEEKMLIVENRFLAQTPKEMSVEEGDVLYLIEQSNREWWYVASKSRQFKGFVPKSHV- 238
Query: 114 IFGRTRPNSHASPVKSI 130
++ R A + SI
Sbjct: 239 VYAEYREPWFAGNISSI 255
>Hs7382493 [C] KOG4773 NADPH oxidase
Length = 348
Score = 32.3 bits (72), Expect = 2.0
Identities = 48/199 (24%), Positives = 73/199 (36%), Gaps = 52/199 (26%)
Query: 325 FQVSCQLSNNTTRILKRYYEDFYDLQVKLLDIFPAEGGKLRDTNGQWTKRIMPYIPGPVP 384
F + + + ++ R Y F+ LQ KL + F D+ +P +P V
Sbjct: 41 FVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGP------DSKSSALACTLPTLPAKVY 94
Query: 385 Y-VTDTISKKRKDDLNIYVKDLISLPPHISQSHLVKGLFAVKNNGFDREISNDETVELDV 443
V I++ R LN Y+K L+SLP + V+ F + +D E
Sbjct: 95 VGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFF--YQSPYDSE----------- 141
Query: 444 KGRADDSTLTNQELQLPEAMKRLSLIXXXXXXXXKVKSRPPSG------FAPR------I 491
Q+P+A++RL KVKS P G APR
Sbjct: 142 --------------QVPQALRRL------RPRTRKVKSVSPQGNSVDRMAAPRAEALFDF 181
Query: 492 TDEKPVKIKFYYKDDIFAL 510
T +++ F D IF L
Sbjct: 182 TGNSKLELNFKAGDVIFLL 200
>Hs4885433 [T] KOG3775 Mitogen-activated protein kinase scaffold protein JIP
Length = 711
Score = 32.3 bits (72), Expect = 2.0
Identities = 18/54 (33%), Positives = 27/54 (49%), Gaps = 1/54 (1%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQ-QEENDWYEASNPADGKRGMVPKNY 111
E+ +A++ + + EL D V+ Q E+ WYEA N G RG+ P Y
Sbjct: 490 EQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYY 543
>CE03428 [U] KOG3771 Amphiphysin
Length = 461
Score = 32.3 bits (72), Expect = 2.0
Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHV-----QQEENDWYEASNPADGKRGMVPKNY 111
+ + +NY+A ELSF +G V + +D + DGKRG+ P+N+
Sbjct: 403 VTSTHNYKAVDTDELSFEQGVQIKVIEANEDDQLDDGWRLGELEDGKRGVFPENF 457
>Hs7662296 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 684
Score = 32.0 bits (71), Expect = 2.6
Identities = 13/30 (43%), Positives = 20/30 (66%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEN 91
+KALY+Y+ Q+ ELSF +G + +EN
Sbjct: 516 VKALYDYEGQTDDELSFPEGAIIRILNKEN 545
>Hs4506431 [R] KOG3508 GTPase-activating protein
Length = 1047
Score = 32.0 bits (71), Expect = 2.6
Identities = 21/70 (30%), Positives = 36/70 (51%), Gaps = 7/70 (10%)
Query: 55 ISSPEKV-----IKALYNY-QAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMV 107
++ PE V ++A+ Y + E+SF KGD F V E E+ W +N ++G++
Sbjct: 272 VAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLI 331
Query: 108 PKNYFEIFGR 117
++ E GR
Sbjct: 332 VEDLVEEVGR 341
>Hs4505345 [C] KOG4773 NADPH oxidase
Length = 339
Score = 32.0 bits (71), Expect = 2.6
Identities = 26/99 (26%), Positives = 42/99 (42%), Gaps = 7/99 (7%)
Query: 325 FQVSCQLSNNTTRILKRYYEDFYDLQVKLLDIFPAEGGKLRDTNGQWTKRIMPYIPGPVP 384
F + + + ++ R Y F+ LQ KL + F D+ +P +P V
Sbjct: 41 FVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGP------DSKSSALACTLPTLPAKVY 94
Query: 385 Y-VTDTISKKRKDDLNIYVKDLISLPPHISQSHLVKGLF 422
V I++ R LN Y+K L+SLP + V+ F
Sbjct: 95 VGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFF 133
>Hs16163690 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 1022
Score = 32.0 bits (71), Expect = 2.6
Identities = 18/52 (34%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 64 ALYNYQAQSAGELSFNKG-DFFHVQQEENDWYEASNPADGKRGMVPKNYFEI 114
A ++Y +SA ELSF KG + DW+E + +G G+VP Y +
Sbjct: 687 AKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRH--NGIDGLVPHQYIVV 736
>Hs12545406 [R] KOG3508 GTPase-activating protein
Length = 870
Score = 32.0 bits (71), Expect = 2.6
Identities = 21/70 (30%), Positives = 36/70 (51%), Gaps = 7/70 (10%)
Query: 55 ISSPEKV-----IKALYNY-QAQSAGELSFNKGDFFHVQQE-ENDWYEASNPADGKRGMV 107
++ PE V ++A+ Y + E+SF KGD F V E E+ W +N ++G++
Sbjct: 95 VAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLI 154
Query: 108 PKNYFEIFGR 117
++ E GR
Sbjct: 155 VEDLVEEVGR 164
>CE21930 [T] KOG4348 Adaptor protein CMS/SETA
Length = 318
Score = 32.0 bits (71), Expect = 2.6
Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYFEIFGRT 118
++ A Y Y ++ ELSF GD + E+ W + + G GM P N+ + +
Sbjct: 49 QIYVATYAYSSKQDDELSFVVGDLIELISDVEDGWSKGKLKSTGAVGMFPTNFVTL--KP 106
Query: 119 RPNSHASPV 127
P++ A+ V
Sbjct: 107 TPSTSAAAV 115
>7293213 [I] KOG1264 Phospholipase C
Length = 1236
Score = 32.0 bits (71), Expect = 2.6
Identities = 21/75 (28%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNS 122
KALY+Y+A ELSF K Q +N + + + +P NY ++ +S
Sbjct: 830 KALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVI-----DS 884
Query: 123 HASPVKSINRNGSVG 137
S+N G+ G
Sbjct: 885 TTEDYNSLNEEGTDG 899
>Hs7706706 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 595
Score = 31.6 bits (70), Expect = 3.4
Identities = 17/55 (30%), Positives = 30/55 (53%), Gaps = 4/55 (7%)
Query: 63 KALYNYQAQSAG-ELSFNKGDFFHVQQEE--NDWYEASNPADGKRGMVPKNYFEI 114
+ +Y++ A+ EL+ N+G+ + + W E N G+RG+VP +Y EI
Sbjct: 6 RVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRN-IKGERGLVPTDYVEI 59
>CE28644 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating
proteins
Length = 910
Score = 31.6 bits (70), Expect = 3.4
Identities = 17/52 (32%), Positives = 22/52 (41%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
+K LY ELSF G E N+ +GK G++P NY E
Sbjct: 827 VKTLYACTPDHHSELSFEPGQIITNVYESNEDGWLVGTLNGKTGLIPSNYVE 878
>7300449 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 368
Score = 31.6 bits (70), Expect = 3.4
Identities = 13/49 (26%), Positives = 32/49 (64%), Gaps = 3/49 (6%)
Query: 63 KALYNYQAQSAGELSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKN 110
+ALY+++ ++ GEL+F + D + + +++W+E + +G+ G P++
Sbjct: 311 QALYDFEPENPGELAFKENDIITLLNRVDDNWFEGA--VNGRTGYFPQS 357
>Hs17474837_1 [Z] KOG1654 Microtubule-associated anchor protein involved in
autophagy and membrane trafficking
Length = 171
Score = 31.6 bits (70), Expect = 3.4
Identities = 14/52 (26%), Positives = 29/52 (54%), Gaps = 3/52 (5%)
Query: 61 VIKALYNYQAQSAGELSFNKGDFFHV-QQEENDWYEASNPADGKRGMVPKNY 111
V++ ++ ++ EL F KGD +V + +W++ + + G+ G+ P NY
Sbjct: 118 VVRKTDHFSPRTPDELCFEKGDIIYVTDMNDANWWKGT--SKGRTGLTPSNY 167
>Hs11968152_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 654
Score = 31.6 bits (70), Expect = 3.4
Identities = 24/86 (27%), Positives = 41/86 (46%), Gaps = 7/86 (8%)
Query: 58 PEKVIKALYNYQAQSAGELSFNKGDFFHVQQ-EENDWYEASNPADGKRGMVPKNYFEIFG 116
P + A+ +YQAQ+ GE+S +KG+ V E ++E G+ G P + E
Sbjct: 555 PGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQ--VKGRVGWFPSDCLEEVA 612
Query: 117 ----RTRPNSHASPVKSINRNGSVGS 138
++ S + K + R+ +VGS
Sbjct: 613 NRSQESKQESRSDKAKRLFRHYTVGS 638
>YLR191w [U] KOG3875 Peroxisomal biogenesis protein peroxin
Length = 386
Score = 31.2 bits (69), Expect = 4.4
Identities = 18/68 (26%), Positives = 34/68 (49%), Gaps = 8/68 (11%)
Query: 63 KALYNYQAQSAG-ELSFNKGDFFHVQQE------ENDWYEASNPADGKRGMVPKNYFEIF 115
+ALY++ ++ E++ KGD + + ++DW++ +G G +P NY EI
Sbjct: 312 RALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRTK-NGNIGYIPYNYIEII 370
Query: 116 GRTRPNSH 123
R + H
Sbjct: 371 KRRKKIEH 378
>Hs7705981 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 366
Score = 31.2 bits (69), Expect = 4.4
Identities = 20/55 (36%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFE 113
EKV+ LY Y +Q ELSF++G V + +D + ++G G P NY E
Sbjct: 311 EKVV-TLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEG-TGFFPGNYVE 363
>Hs4503787 [T] KOG0197 Tyrosine kinases
Length = 505
Score = 31.2 bits (69), Expect = 4.4
Identities = 20/56 (35%), Positives = 28/56 (49%), Gaps = 8/56 (14%)
Query: 64 ALYNYQAQSAGELSFNKGDFFHVQQ--EENDWY--EASNPADGK----RGMVPKNY 111
AL++YQA++A +LSF GD V E W+ DG +G +P NY
Sbjct: 49 ALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNY 104
>Hs11968025 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 503
Score = 31.2 bits (69), Expect = 4.4
Identities = 17/43 (39%), Positives = 23/43 (52%), Gaps = 5/43 (11%)
Query: 76 LSFNKGDFFHV-QQEENDWYEASNPADGKR----GMVPKNYFE 113
LSF KGD HV QE+ +W++A D G+VP F+
Sbjct: 199 LSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQ 241
>CE14974 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 183
Score = 31.2 bits (69), Expect = 4.4
Identities = 21/80 (26%), Positives = 36/80 (44%), Gaps = 2/80 (2%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGKRGMVPKNYFEIFGRTR 119
K+ Y+ Q+ EL+ +KG++ V +E +W+E N + G VP +
Sbjct: 75 KLAVVTYDRGGQNTKELTVHKGEYLEVIFDERNWWECKN-MHQRVGYVPHTILSMV-PFE 132
Query: 120 PNSHASPVKSINRNGSVGSN 139
+ASP N + + G N
Sbjct: 133 QQQYASPNHHNNSSSTGGYN 152
>CE05763 [Z] KOG0162 Myosin class I heavy chain
Length = 1100
Score = 31.2 bits (69), Expect = 4.4
Identities = 16/52 (30%), Positives = 29/52 (55%), Gaps = 3/52 (5%)
Query: 61 VIKALYNYQAQSAGELSFNKG-DFFHVQQEENDWYEASNPADGKRGMVPKNY 111
V+ A+Y Y+AQ ELSF G + + ++ + W++ + + G+ P NY
Sbjct: 1048 VVIAVYPYEAQDVDELSFEAGAEIELMNKDASGWWQGK--VNNRVGLFPGNY 1097
>7293174 [R] KOG3508 GTPase-activating protein
Length = 925
Score = 31.2 bits (69), Expect = 4.4
Identities = 16/54 (29%), Positives = 27/54 (49%), Gaps = 1/54 (1%)
Query: 55 ISSPEKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMV 107
++ ++V+ L + ELSF KGD F V + D W + G++GM+
Sbjct: 151 VNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMI 204
>YMR109w [Z] KOG0162 Myosin class I heavy chain
Length = 1219
Score = 30.8 bits (68), Expect = 5.8
Identities = 18/57 (31%), Positives = 27/57 (46%), Gaps = 2/57 (3%)
Query: 59 EKVIKALYNYQAQ-SAGELSFNKGDFFHVQQEENDWYEASNPADG-KRGMVPKNYFE 113
E + +A Y++ S EL KGD ++ +EE + DG K G VP Y +
Sbjct: 1087 EPMFEAAYDFPGSGSPSELPLKKGDVIYITREEPSGWSLGKLLDGSKEGWVPTAYMK 1143
>YDL117w [D] KOG4575 TGc (transglutaminase/protease-like) domain-containing
protein involved in cytokinesis
Length = 885
Score = 30.8 bits (68), Expect = 5.8
Identities = 16/55 (29%), Positives = 25/55 (45%), Gaps = 1/55 (1%)
Query: 58 PEKVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASNPADGK-RGMVPKNY 111
P +KA Y + Q+ G+L F +GD V + W+ + K G P N+
Sbjct: 10 PPFKVKARYGWSGQTKGDLGFLEGDIMEVTRIAGSWFYGKLLRNKKCSGYFPHNF 64
>HsM14149706 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 408
Score = 30.8 bits (68), Expect = 5.8
Identities = 15/48 (31%), Positives = 24/48 (49%), Gaps = 1/48 (2%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVP 108
++ + ++ A+ ELS D + Q +D WYE DG+RG P
Sbjct: 331 VEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFP 378
>Hs21361487 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 871
Score = 30.8 bits (68), Expect = 5.8
Identities = 15/48 (31%), Positives = 24/48 (49%), Gaps = 1/48 (2%)
Query: 62 IKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVP 108
++ + ++ A+ ELS D + Q +D WYE DG+RG P
Sbjct: 794 VEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFP 841
>Hs20559073 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 552
Score = 30.8 bits (68), Expect = 5.8
Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 76 LSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYFE 113
L FN GD V Q++ +W++A + G G++P E
Sbjct: 251 LRFNAGDLLQIVNQDDANWWQACHVEGGSAGLIPSQLLE 289
>Hs18765725 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 552
Score = 30.8 bits (68), Expect = 5.8
Identities = 13/39 (33%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 76 LSFNKGDFFH-VQQEENDWYEASNPADGKRGMVPKNYFE 113
L FN GD V Q++ +W++A + G G++P E
Sbjct: 251 LRFNAGDLLQIVNQDDANWWQACHVEGGSAGLIPSQLLE 289
>Hs17447529 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 545
Score = 30.8 bits (68), Expect = 5.8
Identities = 18/58 (31%), Positives = 31/58 (53%), Gaps = 7/58 (12%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQ-----EENDWYEASNPADGKRGMVPKNY 111
E++ A++ +QA+S ELS + H+ + +W+ A A G++G VP NY
Sbjct: 483 EQIFYAVHAFQARSDHELSLQEYQRVHILRFCDLSGNKEWWLAE--AQGQKGYVPANY 538
>Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA
Length = 665
Score = 30.8 bits (68), Expect = 5.8
Identities = 15/55 (27%), Positives = 31/55 (56%), Gaps = 5/55 (9%)
Query: 63 KALYNYQAQSAGELSFNKGDFFHVQQE---ENDWYEASNPADGKRGMVPKNYFEI 114
K ++ Y+AQ+ EL+ +GD + + + W+E +G+RG+ P N+ ++
Sbjct: 273 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFVKL 325
>CE27042 [R] KOG2030 Predicted RNA-binding protein
Length = 899
Score = 30.8 bits (68), Expect = 5.8
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 99 PADGKRGMVPKNYFEIFGRTRPNSHASPVKSINRNGSVGSN 139
P GKRG K+ E+F R R + A+ +KS+ + S N
Sbjct: 844 PGIGKRGKATKSAIELFTRQRTDRQAALIKSLLSDDSASRN 884
>YKL129c [Z] KOG0162 Myosin class I heavy chain
Length = 1271
Score = 30.4 bits (67), Expect = 7.5
Identities = 19/71 (26%), Positives = 32/71 (44%), Gaps = 2/71 (2%)
Query: 63 KALYNYQAQ-SAGELSFNKGDFFHVQQEENDWYEASNPADG-KRGMVPKNYFEIFGRTRP 120
+A Y++ S+ EL KGD + ++E + + DG K G VP Y + TR
Sbjct: 1125 EAAYDFPGSGSSSELPLKKGDIVFISRDEPSGWSLAKLLDGSKEGWVPTAYMTPYKDTRN 1184
Query: 121 NSHASPVKSIN 131
+ ++N
Sbjct: 1185 TVPVAATGAVN 1195
>Hs7706537 [T] KOG3775 Mitogen-activated protein kinase scaffold protein JIP
Length = 797
Score = 30.4 bits (67), Expect = 7.5
Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 1/54 (1%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNY 111
E+ +A++ + + EL + D V+ EE+D W+ N G+RG+ P Y
Sbjct: 579 EQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFY 632
>Hs6912492 [T] KOG3775 Mitogen-activated protein kinase scaffold protein JIP
Length = 824
Score = 30.4 bits (67), Expect = 7.5
Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 1/54 (1%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNY 111
E+ +A++ + + EL + D V+ EE+D W+ N G+RG+ P Y
Sbjct: 606 EQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFY 659
>Hs21237775 [T] KOG3775 Mitogen-activated protein kinase scaffold protein JIP
Length = 443
Score = 30.4 bits (67), Expect = 7.5
Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 1/54 (1%)
Query: 59 EKVIKALYNYQAQSAGELSFNKGDFFHVQQEEND-WYEASNPADGKRGMVPKNY 111
E+ +A++ + + EL + D V+ EE+D W+ N G+RG+ P Y
Sbjct: 225 EQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFY 278
>Hs19424130 [O] KOG1366 Alpha-macroglobulin
Length = 1445
Score = 30.4 bits (67), Expect = 7.5
Identities = 20/65 (30%), Positives = 25/65 (37%)
Query: 434 SNDETVELDVKGRADDSTLTNQELQLPEAMKRLSLIXXXXXXXXKVKSRPPSGFAPRITD 493
S DE EL V GR D L + +L KR+S+ K K +D
Sbjct: 97 SADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSD 156
Query: 494 EKPVK 498
KP K
Sbjct: 157 FKPYK 161
>Hs11342676 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 545
Score = 30.4 bits (67), Expect = 7.5
Identities = 15/60 (25%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 56 SSPEKVIKALYNYQAQSAGELSFNKG-DFFHVQQEENDWYEASNPADGKRGMVPKNYFEI 114
+SP A+Y+++ S G +S +G D +++++ D + +G G VP +Y +
Sbjct: 483 TSPIGHCVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRV 542
>YMR012w [R] KOG1839 Uncharacterized protein CLU1/cluA/TIF31 involved in
mitochondrial morphology/distribution also found
associated with eIF-3
Length = 1277
Score = 30.0 bits (66), Expect = 9.8
Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 390 ISKKRKDDLNIYVKDLISLPPHISQSHLVKGL---FAVKNNGFDREISNDETVE--LDVK 444
+S+K+++ N VK + LP + SH K L + KNN EI + ++ LDV
Sbjct: 1 MSEKKEEVKNATVKVTVKLPKEDNHSHNTKHLKKTQSSKNNDISFEIGKESKIQTVLDVL 60
Query: 445 GRADDST-LTNQELQLPEAMKRLS 467
S LTN L+ E +LS
Sbjct: 61 AMIPSSKYLTNVGLKTIEGDSQLS 84
>Hs4758956 [TZ] KOG3632 Peripheral benzodiazepine receptor PRAX-1
Length = 1857
Score = 30.0 bits (66), Expect = 9.8
Identities = 21/66 (31%), Positives = 30/66 (44%), Gaps = 6/66 (9%)
Query: 54 DISSPEKVIKAL-YNYQAQSAG-----ELSFNKGDFFHVQQEENDWYEASNPADGKRGMV 107
D+ +P ++ A YN Q S EL F GD V +D +G+RG+V
Sbjct: 1762 DLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGELNGQRGLV 1821
Query: 108 PKNYFE 113
P N+ E
Sbjct: 1822 PSNFLE 1827
>Hs20535816 [T] KOG0695 Serine/threonine protein kinase
Length = 592
Score = 30.0 bits (66), Expect = 9.8
Identities = 12/29 (41%), Positives = 18/29 (61%)
Query: 497 VKIKFYYKDDIFALMLHPTITFEELCSKI 525
V++K +Y DIF + TFEELC ++
Sbjct: 16 VRLKAHYGGDIFITSVDAATTFEELCEEV 44
>Hs15718680 [T] KOG0197 Tyrosine kinases
Length = 620
Score = 30.0 bits (66), Expect = 9.8
Identities = 16/54 (29%), Positives = 27/54 (49%), Gaps = 2/54 (3%)
Query: 59 EKVIKALYNYQAQSAGELSFNKG-DFFHVQQEENDWYEASNPADGKRGMVPKNY 111
E V+ ALY+YQ EL+ + ++ + E W+ + +G G VP +Y
Sbjct: 173 ETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSY 225
>Hs10864650 [T] KOG0695 Serine/threonine protein kinase
Length = 592
Score = 30.0 bits (66), Expect = 9.8
Identities = 12/29 (41%), Positives = 18/29 (61%)
Query: 497 VKIKFYYKDDIFALMLHPTITFEELCSKI 525
V++K +Y DIF + TFEELC ++
Sbjct: 16 VRLKAHYGGDIFITSVDAATTFEELCEEV 44
>CE14976 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 929
Score = 30.0 bits (66), Expect = 9.8
Identities = 12/39 (30%), Positives = 22/39 (55%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASN 98
K+ Y+ Q+ EL+ +KG++ V +E +W+E N
Sbjct: 513 KLAVVTYDRGGQNTKELTVHKGEYLEVIFDERNWWECKN 551
>CE14972 [T] KOG3557 Epidermal growth factor receptor kinase substrate
Length = 732
Score = 30.0 bits (66), Expect = 9.8
Identities = 12/39 (30%), Positives = 22/39 (55%)
Query: 60 KVIKALYNYQAQSAGELSFNKGDFFHVQQEENDWYEASN 98
K+ Y+ Q+ EL+ +KG++ V +E +W+E N
Sbjct: 513 KLAVVTYDRGGQNTKELTVHKGEYLEVIFDERNWWECKN 551
>7290607 [A] KOG2253 U1 snRNP complex subunit SNU71 and related PWI-motif
proteins
Length = 998
Score = 30.0 bits (66), Expect = 9.8
Identities = 20/54 (37%), Positives = 28/54 (51%), Gaps = 4/54 (7%)
Query: 86 VQQEENDWYEASNPADGKRGMVPKNYFEIFGRTRPNSHASPVKSINRNGSVGSN 139
V ++ND E NP KR +VP +Y + T P++HA+ S N S SN
Sbjct: 733 VNDDDND--ENINPK--KRKLVPLDYDDNISNTTPSNHAASSGSGAANNSSSSN 782
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,796,700
Number of Sequences: 60738
Number of extensions: 1292101
Number of successful extensions: 3065
Number of sequences better than 10.0: 204
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 2722
Number of HSP's gapped (non-prelim): 399
length of query: 569
length of database: 30,389,216
effective HSP length: 112
effective length of query: 457
effective length of database: 23,586,560
effective search space: 10779057920
effective search space used: 10779057920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)