ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV6319 good R KOG3798 General function prediction only Predicted Zn-dependent hydrolase (beta-lactamase superfamily)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV6319 2167004 2168335 444
(444 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL103c [R] KOG3798 Predicted Zn-dependent hydrolase (beta-lacta... 462 e-130
CE28519 [R] KOG3798 Predicted Zn-dependent hydrolase (beta-lacta... 164 3e-40
CE27604 [R] KOG3798 Predicted Zn-dependent hydrolase (beta-lacta... 164 3e-40
CE21545 [R] KOG3798 Predicted Zn-dependent hydrolase (beta-lacta... 160 3e-39
Hs20543009 [R] KOG3798 Predicted Zn-dependent hydrolase (beta-la... 79 1e-14
>YPL103c [R] KOG3798 Predicted Zn-dependent hydrolase (beta-lactamase
superfamily)
Length = 468
Score = 462 bits (1190), Expect = e-130
Identities = 228/434 (52%), Positives = 294/434 (67%), Gaps = 22/434 (5%)
Query: 16 ARNYTQKSTKQTRRTGLKILLYFSIPYTGYALYVFGSTNYEITRR----ERQLADKDDLE 71
A T+ K +R+ +LL +PYTGYA YV +T +I R +R + +++
Sbjct: 40 ASQKTRPIQKCSRKYARILLLSVLVPYTGYAFYVSLATVKQIDLRNEMCQRLEENNNEVT 99
Query: 72 FKSTLVKYSPFQVLGRFENPFNEYRIQTXXXXXXXXXXXXXXXXXGGLPRSKEQMDELMP 131
+K +L+KYSP +VLGRFENPF EYRIQT GG+PR QM++LMP
Sbjct: 100 YKGSLLKYSPLEVLGRFENPFEEYRIQTVFEFFANRVFELFERNRGGIPRDVHQMNKLMP 159
Query: 132 IHKPTWVTKGVLDNSHNEIEVEIK---------PFSSDEKEVNTEPVKRLYCTWLGQSCS 182
+HKPTW V + E + ++ P + +E E + PV Y TWLGQSC+
Sbjct: 160 VHKPTWGPNLVDVDPAEETALPLECKVLDELHIPTAVEENEGSKCPV---YNTWLGQSCN 216
Query: 183 VIILDKLKILTDPMFSKHLIHPTFGPQRITDMPAKIEDVPTPDLILVSHNHPDHLDEKSL 242
+ + L+ILTDP+FS LIH T GP+RIT MP++I +VP PD+ILVSHNHPDHLD +SL
Sbjct: 217 YTVYNGLRILTDPLFSDFLIHKTLGPKRITQMPSQITEVPKPDIILVSHNHPDHLDLESL 276
Query: 243 KFWGDDHPQKPMWIVPKGLASYMIMNNVSNFTELSWWETCHVKIKGAQEDTIYQISSTPA 302
++W P+WIVPKG+ SYM N N ELSWWET VK + + IY IS+TPA
Sbjct: 277 EYWSGK--DSPLWIVPKGMKSYMTSNGCDNVLELSWWETLQVK----KNNEIYHISATPA 330
Query: 303 MHWSGRSVLDANRSLWCSFIVHKGNKPVLFHAGDTGFVHDLYKRIVKKYGSGVRLALLPC 362
MHWSGRS+LD N+SLWCSF++ P+LFHAGDTG+V DL+ RI +++G G +LALLPC
Sbjct: 331 MHWSGRSLLDTNKSLWCSFLLTHHGNPILFHAGDTGYVKDLFVRIKERFGKGCKLALLPC 390
Query: 363 GQYCPEWHQRPRHINPAEVIKIMNDLDAQTALGIHWGTFLLSGEYFREPKEKLEFLSEFN 422
GQYCPEWHQ+PRHINP EV+KIM DL+A+ LG+HWGTF+LSGEYF EPKEKLE L+E+
Sbjct: 391 GQYCPEWHQKPRHINPQEVLKIMKDLEARNVLGVHWGTFVLSGEYFLEPKEKLEMLAEWG 450
Query: 423 ELKDRCFCPELGET 436
KDRC+CPELG+T
Sbjct: 451 GFKDRCYCPELGKT 464
>CE28519 [R] KOG3798 Predicted Zn-dependent hydrolase (beta-lactamase
superfamily)
Length = 376
Score = 164 bits (414), Expect = 3e-40
Identities = 100/303 (33%), Positives = 164/303 (54%), Gaps = 21/303 (6%)
Query: 149 EIEVEIKPFSSDEKEVNTEPVKRLYCTWLGQSCSVIILDKLKILTDPMFSKHLIHPTF-G 207
++E+ + ++D+ ++ L+ TWLG + ++ L+ +K +TDP+++ +F G
Sbjct: 84 DVEIPVHNITADDFHSESD----LFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAG 139
Query: 208 PQRITDMPAKIEDVPTPDLILVSHNHPDHLDEKSLKFWGDDHPQKPMWIVPKGLASYM-- 265
P+R P K+ED+P D +VSH+H DHLD ++K D +PQ W VP G+ +M
Sbjct: 140 PKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKKITDRNPQIK-WFVPLGMKKWMEG 198
Query: 266 ----IMNNVSNFTELSWWETCHVKIKGAQEDTIYQISSTPAMHWSGRSVLDANRSLWCSF 321
+ + + TEL+W E+ G Y I PA HW R + D N LW +
Sbjct: 199 QGIGVDGSSTAVTELNWGESSEFVKNGKT----YTIWCLPAQHWGQRGLFDRNHRLWSGW 254
Query: 322 IVHKGNKPVLFHAGDTGFVHDLYKRIVKKYGSGVRLALLPCGQYCPEWHQRPRHINPAEV 381
V N+ +++GDTG +K+ +K G LA +P G Y P W + +HINP E
Sbjct: 255 AVIGENRR-FYYSGDTGHCDGEFKKFGEKLGP-FDLAAIPIGAYEPRWFMKSQHINPEEA 312
Query: 382 IKIMNDLDAQTALGIHWGTFLL-SGEYFREPKEKLEFLSEFNE-LKDRCFCP-ELGETLD 438
I++ + A+ ++GIHWGT+ + S EY+ EP++KL+ L + E LK+ F E+G +
Sbjct: 313 IEVHKLIRAKNSIGIHWGTYHMGSTEYYLEPRDKLKELMDAREDLKNTSFVTIEMGRIWE 372
Query: 439 FSN 441
S+
Sbjct: 373 ASD 375
>CE27604 [R] KOG3798 Predicted Zn-dependent hydrolase (beta-lactamase
superfamily)
Length = 355
Score = 164 bits (414), Expect = 3e-40
Identities = 100/303 (33%), Positives = 164/303 (54%), Gaps = 21/303 (6%)
Query: 149 EIEVEIKPFSSDEKEVNTEPVKRLYCTWLGQSCSVIILDKLKILTDPMFSKHLIHPTF-G 207
++E+ + ++D+ ++ L+ TWLG + ++ L+ +K +TDP+++ +F G
Sbjct: 63 DVEIPVHNITADDFHSESD----LFATWLGHATVLVDLEGVKFVTDPVWADRASFTSFAG 118
Query: 208 PQRITDMPAKIEDVPTPDLILVSHNHPDHLDEKSLKFWGDDHPQKPMWIVPKGLASYM-- 265
P+R P K+ED+P D +VSH+H DHLD ++K D +PQ W VP G+ +M
Sbjct: 119 PKRYRPPPMKLEDLPDLDFAVVSHDHYDHLDADAVKKITDRNPQIK-WFVPLGMKKWMEG 177
Query: 266 ----IMNNVSNFTELSWWETCHVKIKGAQEDTIYQISSTPAMHWSGRSVLDANRSLWCSF 321
+ + + TEL+W E+ G Y I PA HW R + D N LW +
Sbjct: 178 QGIGVDGSSTAVTELNWGESSEFVKNGKT----YTIWCLPAQHWGQRGLFDRNHRLWSGW 233
Query: 322 IVHKGNKPVLFHAGDTGFVHDLYKRIVKKYGSGVRLALLPCGQYCPEWHQRPRHINPAEV 381
V N+ +++GDTG +K+ +K G LA +P G Y P W + +HINP E
Sbjct: 234 AVIGENRR-FYYSGDTGHCDGEFKKFGEKLGP-FDLAAIPIGAYEPRWFMKSQHINPEEA 291
Query: 382 IKIMNDLDAQTALGIHWGTFLL-SGEYFREPKEKLEFLSEFNE-LKDRCFCP-ELGETLD 438
I++ + A+ ++GIHWGT+ + S EY+ EP++KL+ L + E LK+ F E+G +
Sbjct: 292 IEVHKLIRAKNSIGIHWGTYHMGSTEYYLEPRDKLKELMDAREDLKNTSFVTIEMGRIWE 351
Query: 439 FSN 441
S+
Sbjct: 352 ASD 354
>CE21545 [R] KOG3798 Predicted Zn-dependent hydrolase (beta-lactamase
superfamily)
Length = 356
Score = 160 bits (406), Expect = 3e-39
Identities = 109/332 (32%), Positives = 171/332 (50%), Gaps = 42/332 (12%)
Query: 119 LPRSKEQMDELMPIHKPTWVTKGVLDNSHNEIEVEIKPFSSDEKEVNTEPVKRLYCTWLG 178
LP K+ +D +P+H T D+ H+E L+ TWLG
Sbjct: 57 LPSDKKVLDSTLPVHNIT------ADDFHSE--------------------SGLFATWLG 90
Query: 179 QSCSVIILDKLKILTDPMFSKHLIHPTF-GPQRITDMPAKIEDVPTPDLILVSHNHPDHL 237
+ ++ L+ +K +TDP+++ +F GP+R P K+ED+P D +VSH+H DHL
Sbjct: 91 HATVLVDLEGVKFVTDPVWADRASFTSFAGPKRYRPPPMKLEDLPDLDFAVVSHDHYDHL 150
Query: 238 DEKSLKFWGDDHPQKPMWIVPKGLASYMIMNNV-----SNFTELSWWETCHVKIKGAQED 292
D ++K + +PQ W VP GL +M + + TEL+W E+ +K +
Sbjct: 151 DADAVKRITNLNPQIK-WFVPLGLKKWMKNQGIGADGSNTVTELNWGESSEF-VKNGKTI 208
Query: 293 TIYQISSTPAMHWSGRSVLDANRSLWCSFIVHKGNKPVLFHAGDTGFVHDLYKRIVKKYG 352
TI+ + PA H R + D N LW + V N+ F GDTGF +K+I +K G
Sbjct: 209 TIWCL---PAQHSGQRGLSDHNHRLWSGWAVIGENRRFYF-PGDTGFCDVEFKKIGEKLG 264
Query: 353 SGVRLALLPCGQYCPEWHQRPRHINPAEVIKIMNDLDAQTALGIHWGTFLL-SGEYFREP 411
LA +P G Y P W + HINP E +++ + A+ ++GIHWGT+ + + EY+ EP
Sbjct: 265 P-FDLAAIPIGAYEPRWFMKSHHINPDEAVEVHKLVRARNSIGIHWGTYPMGTTEYYLEP 323
Query: 412 KEKLEFLSEFNE-LKDRCFCP-ELGETLDFSN 441
++KL+ L + E LKD F ++GE + S+
Sbjct: 324 RDKLKELMDAREDLKDTSFVTVDMGEIWEASD 355
>Hs20543009 [R] KOG3798 Predicted Zn-dependent hydrolase (beta-lactamase
superfamily)
Length = 134
Score = 79.3 bits (194), Expect = 1e-14
Identities = 47/135 (34%), Positives = 75/135 (54%), Gaps = 4/135 (2%)
Query: 311 LDANRSLWCSFIVHKGNKPVLFHAGDTGFVHDLYKRIVKKYGSGVRLALLPCGQYCPEWH 370
+D N+ LW S+ V G F AGDTG+ ++ I K++G LA +P G Y P W
Sbjct: 1 MDDNKVLWGSWSV-LGPWNRFFFAGDTGYC-PAFEEIGKRFGP-FDLAAIPIGAYEPRWF 57
Query: 371 QRPRHINPAEVIKIMNDLDAQTALGIHWGTFLLSGEYFREPKEKL-EFLSEFNELKDRCF 429
+ +H++P E ++I D+ + ++ IHWGTF L+ E++ EP KL E L + + F
Sbjct: 58 MKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAEDFF 117
Query: 430 CPELGETLDFSNNVE 444
+ GE+ +N+ E
Sbjct: 118 VLKHGESRYLNNDDE 132
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.138 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,112,080
Number of Sequences: 60738
Number of extensions: 1257837
Number of successful extensions: 2452
Number of sequences better than 1.0e-05: 5
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 2428
Number of HSP's gapped (non-prelim): 5
length of query: 444
length of database: 30,389,216
effective HSP length: 110
effective length of query: 334
effective length of database: 23,708,036
effective search space: 7918484024
effective search space used: 7918484024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)