ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0023 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0023 4320 5840 507
(507 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL221w [G] KOG2504 Monocarboxylate transporter 388 e-107
YNL125c [G] KOG2504 Monocarboxylate transporter 209 6e-54
7292012 [G] KOG2504 Monocarboxylate transporter 86 1e-16
Hs4759112 [G] KOG2504 Monocarboxylate transporter 84 4e-16
CE21446 [G] KOG2504 Monocarboxylate transporter 80 6e-15
CE20478 [G] KOG2504 Monocarboxylate transporter 80 6e-15
CE04864 [G] KOG2504 Monocarboxylate transporter 77 5e-14
7302291 [G] KOG2504 Monocarboxylate transporter 77 5e-14
7290288 [G] KOG2504 Monocarboxylate transporter 77 8e-14
Hs4759120 [G] KOG2504 Monocarboxylate transporter 74 4e-13
CE29573 [G] KOG2504 Monocarboxylate transporter 73 9e-13
Hs22064599 [G] KOG2504 Monocarboxylate transporter 72 2e-12
CE02803 [G] KOG2504 Monocarboxylate transporter 71 3e-12
CE12336 [G] KOG2504 Monocarboxylate transporter 71 4e-12
Hs5730045 [G] KOG2504 Monocarboxylate transporter 67 8e-11
Hs20559959 [G] KOG2504 Monocarboxylate transporter 66 1e-10
Hs7019529 [G] KOG2504 Monocarboxylate transporter 65 3e-10
YOR306c [G] KOG2504 Monocarboxylate transporter 64 5e-10
7295764 [G] KOG2504 Monocarboxylate transporter 62 2e-09
Hs18699730 [G] KOG2504 Monocarboxylate transporter 61 5e-09
Hs4759118 [G] KOG2504 Monocarboxylate transporter 60 8e-09
YOL119c [G] KOG2504 Monocarboxylate transporter 60 1e-08
CE05457 [G] KOG2504 Monocarboxylate transporter 56 1e-07
7299667 [G] KOG2504 Monocarboxylate transporter 55 2e-07
7303008 [G] KOG2504 Monocarboxylate transporter 54 6e-07
7303213 [G] KOG2504 Monocarboxylate transporter 52 2e-06
Hs4759116 [G] KOG2504 Monocarboxylate transporter 52 2e-06
>YKL221w [G] KOG2504 Monocarboxylate transporter
Length = 473
Score = 388 bits (996), Expect = e-107
Identities = 197/443 (44%), Positives = 273/443 (61%), Gaps = 3/443 (0%)
Query: 66 IKVPDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDYAAIGGLSFG 125
I+VPDGGYGW ++ + L NF T GA+ GY +YL++Y+++ + G KLDYA+IGGL+F
Sbjct: 33 IEVPDGGYGWFILLAFILYNFSTWGANSGYAIYLAHYLENNTFAGGSKLDYASIGGLAFS 92
Query: 126 VGVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAI 185
G+ F+P+ ++ S + +I LGI+ Q A LLAAFS LW++YLTQGV I G I
Sbjct: 93 CGLFFAPVITWLYHIFSIQFIIGLGILFQGAALLLAAFSVTLWEIYLTQGVLIGFGLAFI 152
Query: 186 CFPNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALISQCIICSV 245
P+ T+ WFR KRSLA FNL Q I+ KWALI+QCIIC+
Sbjct: 153 FIPSVTLIPLWFRNKRSLASGIGTAGSGLGGIVFNLGMQSILQKRGVKWALIAQCIICTS 212
Query: 246 LSTVAVLLIRTRRDEVQKYSDT-PTTAVALDMFKYPVIWLLILWVCFTMLGYVVQVYSLF 304
LST+A++L RT ++++ + + D+ +WLL +V F MLGYVV +YSL
Sbjct: 213 LSTIALMLTRTTHQGLRQHKRSYKFELLDYDVLSNFAVWLLFGFVSFAMLGYVVLLYSLS 272
Query: 305 SFTISLGYTSKQASAVSXXXXXXXXXXRPLVGLAADKFGAVTTGMFCHLIVAILCYGMWI 364
FT+SLGYTSKQ S VS RP+VG ADK+G++T GM HL++AILC+ MWI
Sbjct: 273 DFTVSLGYTSKQGSYVSCMVSVGSLLGRPIVGHIADKYGSLTVGMILHLVMAILCWAMWI 332
Query: 365 PCRNYATVVVFGLFEGMLMGSIWLLLTSIITRLVGLPKLEAVYSVVWMFLGVCAIVSPVI 424
PC+N AT + FGL G +MG+IW + SI+TR+VGL KL + W+F+ A+V+P+I
Sbjct: 333 PCKNLATAIRFGLLVGSIMGTIWPTIASIVTRIVGLQKLPGTFGSTWIFMAAFALVAPII 392
Query: 425 GISLAKNNVKPGENAYLYTAVYCGTAYLLAALALWCIRGIIIARDKVSLVEKTGYDDGEL 484
G+ L + N Y TA++ G AY +L W +RG IIARD++++ E D EL
Sbjct: 393 GLELRSTDT--NGNDYYRTAIFVGFAYFGVSLCQWLLRGFIIARDEIAVREAYSADQNEL 450
Query: 485 HLRVNLVDALKGMAHYGKLYRKV 507
HL V L K + Y +L R+V
Sbjct: 451 HLNVKLSHMSKCLFRYKQLPRRV 473
>YNL125c [G] KOG2504 Monocarboxylate transporter
Length = 673
Score = 209 bits (533), Expect = 6e-54
Identities = 139/481 (28%), Positives = 227/481 (46%), Gaps = 29/481 (6%)
Query: 2 SATLQSIMSENNTTFREKGEAATSLETSNISSAGELKDPGRLEKEQTIYEFETVPEDE-- 59
S++ S S N T K + L + + A K G+ + Q I EFE P++
Sbjct: 135 SSSAFSASSIQNDTTEHKASMDSKLMRNRLYPAST-KHSGKDLEAQGITEFE--PDEPTV 191
Query: 60 -----DDSYNKIKVP-DGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGK 113
+ S ++++P DGGYGWVV F FL F T G + +GV L+YY++ Y K
Sbjct: 192 KKVFTNKSTGQLELPPDGGYGWVVTFCVFLTMFSTWGCNASFGVDLAYYLNHDTYPGASK 251
Query: 114 LDYAAIGGLSFGVGVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLT 173
DYA I GL+ +G L SPL ++ R + G + A LLA+F+TKLWQ+Y+T
Sbjct: 252 YDYALIAGLTVFLGQLLSPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKLWQLYVT 311
Query: 174 QGVFISIGTGAICFPNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNY-DS 232
QG + I P TT+ WF KKR++A+ + L+T +++ ++ ++
Sbjct: 312 QGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNT 371
Query: 233 KWALISQCIICSVLSTVAVLLIRTRRDEVQKYSDTP-------TTAVALDMFKYPVIWLL 285
+W L I CS+ VA+ L++ R +P +L + P + L+
Sbjct: 372 RWCLRIIGISCSISVLVAIALLKERNPTPAIGLKSPRAMFEQLKAMFSLKVITKPFVVLI 431
Query: 286 ILWVCFTMLGYVVQVYSLFSFTISLGYTSKQASAVSXXXXXXXXXXRPLVGLAADKFGAV 345
LW F + Y + V++L S+ IS G +S AS ++ RPL+GLA DKFG
Sbjct: 432 ALWFMFALFAYNMMVFTLSSYAISKGLSSHDASTLTAILNGSQSIGRPLMGLAGDKFGRA 491
Query: 346 TTGMFCHLIVAILCYGMWIPCRNYATVVVFGLFEGMLMGSIWLLLTSIITRLVG----LP 401
+ ++ I + WIP + ++ F + G +G ++ T +I +V LP
Sbjct: 492 NVTIVLTTLLTIYMFAFWIPAHTFVQLIFFSILVGSCVGVANVMNTVLIADMVKPEEFLP 551
Query: 402 KLEAVYSVVWMFLGVCAIVSPVIGISLAKNNVKPGENAYLYTAVYCGTAYLLAALALWCI 461
V FL VC +++ + + K N YL+ ++CG ++ A + + +
Sbjct: 552 AWAFVNYCGAPFLLVCEVIAQALTVE------KDKSNPYLHAQIFCGCCFIAALILISIL 605
Query: 462 R 462
R
Sbjct: 606 R 606
>7292012 [G] KOG2504 Monocarboxylate transporter
Length = 816
Score = 85.9 bits (211), Expect = 1e-16
Identities = 59/206 (28%), Positives = 92/206 (44%), Gaps = 9/206 (4%)
Query: 38 KDPGRLEKEQTIYEFETVPEDEDDS-----YNKIKVP-DGGYGWVVVFSSFLLNFCTSGA 91
++ RL EQ+ + + DEDD Y ++ P DGGYGWV+ F+SF+ N G
Sbjct: 35 EEAARLTAEQSPEDEDNQDNDEDDDDEESVYGELPPPPDGGYGWVICFASFMCNMIVDGI 94
Query: 92 SYGYGVYLSYYMDSGKYETGGKLDYAAIGGLSFGVGVLFSPLYNYILINTSPRKLISLGI 151
+Y +G++L ++ Y GK A +G L GV + P+ + + R + G
Sbjct: 95 AYTFGIFLEEFV---AYFHEGKGTVAWVGSLLSGVYLSAGPIVSALANKYGCRAVCIAGS 151
Query: 152 VIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICFPNTTIAAPWFRKKRSLALXXXXXX 211
+I +A +L+ FST + + T G G G I P +F KRSLA
Sbjct: 152 IIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFETKRSLATGIAVCG 211
Query: 212 XXXXXXXFNLSTQRIIDNYDSKWALI 237
F +++ Y K AL+
Sbjct: 212 SGFGTFAFAPLATYLLEEYGWKNALL 237
>Hs4759112 [G] KOG2504 Monocarboxylate transporter
Length = 465
Score = 84.3 bits (207), Expect = 4e-16
Identities = 93/427 (21%), Positives = 162/427 (37%), Gaps = 46/427 (10%)
Query: 60 DDSYNKIKVPDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETG-GKLDYAA 118
D+ +K PDGG+GW V+F F++ +G SY + +S + E G G D A
Sbjct: 7 DEGPTGVKAPDGGWGWAVLFGCFVI----TGFSYAFPKAVSVFFKELIQEFGIGYSDTAW 62
Query: 119 IGGLSFGVGVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFI 178
I + + PL + + R ++ +G + ++ + A+F + QVYLT GV
Sbjct: 63 ISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVIT 122
Query: 179 SIGTGAICFPNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSK----- 233
+G P+ + +F K+R +A + Q + D Y +
Sbjct: 123 GLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLI 182
Query: 234 -WALISQCIICSVLSTVAVLLIRTRRDEVQKYSDTPTTA---VALDMFKYPVIWLLILWV 289
L+ C +C+ L V+ Q S P + + L +F+ L +
Sbjct: 183 LGGLLLNCCVCAALMRPLVV-------TAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAA 235
Query: 290 CFTMLGYVVQVYSLFSFTISLGYTSKQASAVSXXXXXXXXXXRPLVGLAADKFGAVTTGM 349
+LG V + S+ LG +A+ + RP G A G
Sbjct: 236 SVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAG------LGK 289
Query: 350 FCHLIVAILCYGMWI---------PCRNYATVVVFGLFEGMLMGSIWLLLTSIITRLVGL 400
V + + M+ +Y +VVF +F G+ G + L ++ +VG
Sbjct: 290 VRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGT 349
Query: 401 PKLEAVYSVVWMFLGVCAIVSPVIGISLAKNNVKPGENAYLYTAVYCGTAYLLAALAL-- 458
K + +V + V +V P G + + Y+Y + G L ++L L
Sbjct: 350 HKFSSAIGLVLLMEAVAVLVGPPSG-----GKLLDATHVYMYVFILAGAEVLTSSLILLL 404
Query: 459 ---WCIR 462
+CIR
Sbjct: 405 GNFFCIR 411
>CE21446 [G] KOG2504 Monocarboxylate transporter
Length = 666
Score = 80.5 bits (197), Expect = 6e-15
Identities = 50/150 (33%), Positives = 77/150 (51%), Gaps = 7/150 (4%)
Query: 57 EDEDDSYNKIKVPDGGYGWVVVFSSFLLNFCTSGASYGYG-VYLSYYMDS-GKYETGGKL 114
E++ + K+ PDGGYGWVVV +SFL+N G Y G + + + D G G +
Sbjct: 28 EEQVEEVGKVTPPDGGYGWVVVAASFLVNMAVDGVIYTCGKILVPIWADQFGSTSVAGAV 87
Query: 115 DYAAIGGLSFGVGVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQ 174
+ + G + G L S N I R + G ++ A LL+ F++ +W++YL
Sbjct: 88 -ISILTGCYYLAGPLASSFVNVFGI----RSVAIAGSILATTAFLLSRFASTIWELYLLF 142
Query: 175 GVFISIGTGAICFPNTTIAAPWFRKKRSLA 204
GV IG G + P+ I + +F KKRS+A
Sbjct: 143 GVLGGIGFGCMYLPSIVILSTYFAKKRSVA 172
>CE20478 [G] KOG2504 Monocarboxylate transporter
Length = 571
Score = 80.5 bits (197), Expect = 6e-15
Identities = 50/150 (33%), Positives = 77/150 (51%), Gaps = 7/150 (4%)
Query: 57 EDEDDSYNKIKVPDGGYGWVVVFSSFLLNFCTSGASYGYG-VYLSYYMDS-GKYETGGKL 114
E++ + K+ PDGGYGWVVV +SFL+N G Y G + + + D G G +
Sbjct: 28 EEQVEEVGKVTPPDGGYGWVVVAASFLVNMAVDGVIYTCGKILVPIWADQFGSTSVAGAV 87
Query: 115 DYAAIGGLSFGVGVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQ 174
+ + G + G L S N I R + G ++ A LL+ F++ +W++YL
Sbjct: 88 -ISILTGCYYLAGPLASSFVNVFGI----RSVAIAGSILATTAFLLSRFASTIWELYLLF 142
Query: 175 GVFISIGTGAICFPNTTIAAPWFRKKRSLA 204
GV IG G + P+ I + +F KKRS+A
Sbjct: 143 GVLGGIGFGCMYLPSIVILSTYFAKKRSVA 172
>CE04864 [G] KOG2504 Monocarboxylate transporter
Length = 556
Score = 77.4 bits (189), Expect = 5e-14
Identities = 49/170 (28%), Positives = 73/170 (42%), Gaps = 5/170 (2%)
Query: 69 PDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYM-DSGKYETGGKLDYAAIGGLSFGVG 127
PDGG+GWVVV SF ++ G Y +G+ M + T L + + G + G G
Sbjct: 15 PDGGWGWVVVIGSFFIHVFADGFVYSFGILAEKLMIEFNSNNTMTSLIVSMLTGFTLGAG 74
Query: 128 VLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICF 187
L S + N R +G + V LL+ F+T++W ++ GV + IG G +
Sbjct: 75 PLASAVCN----KYGCRITTIIGAGVAFVGCLLSCFATEIWHFVISVGVIMGIGFGLVYC 130
Query: 188 PNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALI 237
P I +F KRSLA F II NY ++ +
Sbjct: 131 PAIVIVTMYFESKRSLATGIAVAGAGVGAVVFGPINTFIISNYGWRYVFV 180
>7302291 [G] KOG2504 Monocarboxylate transporter
Length = 800
Score = 77.4 bits (189), Expect = 5e-14
Identities = 65/252 (25%), Positives = 110/252 (42%), Gaps = 21/252 (8%)
Query: 41 GRLEKEQTIYEFETVPEDEDDSYNKI--KVPDGGYGWVVVFSSFLLNFCTSGASYGYG-- 96
G++++ + + E+ + S K K+PDGGYGWVVVF+S +++ G S+ +G
Sbjct: 9 GQVKRRKRLISNESGDSIDSSSTEKKTPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLI 68
Query: 97 -VYLSYYMDSGKYETGGKLDYAAIGGLSFGVGVLFSPLYNYILINTSPRKLISLGIVIQN 155
V L Y +T A I L F V +L P+++ ++ RK+ LG V+
Sbjct: 69 NVELLEYFGESTSKT------AWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSA 122
Query: 156 VAALLAAFSTKLWQVYLTQGVFISIGTGAICFPNTTIAAPWFRKKRSLALXXXXXXXXXX 215
L++F + + +T G+ +G G A WF KKR+ A
Sbjct: 123 FGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIG 182
Query: 216 XXXFNLSTQRIIDNYDSKWA-------LISQCIICSVLSTVAVLLIRTRRDEVQKYSDT- 267
+ T +I++Y + A +++ C +C L LI R E + S T
Sbjct: 183 TFVYARLTSYLIESYGWRGATLILGGTMLNAC-VCGALMRDPDWLIEENRLESRSQSVTT 241
Query: 268 -PTTAVALDMFK 278
++V L+ K
Sbjct: 242 FSNSSVCLEEIK 253
>7290288 [G] KOG2504 Monocarboxylate transporter
Length = 715
Score = 76.6 bits (187), Expect = 8e-14
Identities = 46/169 (27%), Positives = 78/169 (45%), Gaps = 3/169 (1%)
Query: 69 PDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDYAAIGGLSFGVGV 128
PDGG+GWVVVF SF+++ T G +Y +G++ + ++D Y GK A I + GV
Sbjct: 118 PDGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLD---YFNEGKGYTAWIASIMVGVTF 174
Query: 129 LFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICFP 188
P+ + + R + G ++ +++ F+ + + +T G +G G I P
Sbjct: 175 SSGPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLP 234
Query: 189 NTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALI 237
+F KRSLA F T+ +I NY + A++
Sbjct: 235 AIVSVTQYFEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAML 283
>Hs4759120 [G] KOG2504 Monocarboxylate transporter
Length = 478
Score = 74.3 bits (181), Expect = 4e-13
Identities = 87/438 (19%), Positives = 175/438 (39%), Gaps = 70/438 (15%)
Query: 69 PDGGYGWVVVFSSFLLNFCTSGASYGYGVYLS-YYMDSGKYETGGKLDYAAIGGLSFGVG 127
PDGG+GW+VV ++F+ + G SY + ++ ++ + + + A I + V
Sbjct: 14 PDGGWGWIVVGAAFI----SIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVM 69
Query: 128 VLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICF 187
P+ + ++ R ++ G ++ + +LA+FS+ + Q+YLT G +G
Sbjct: 70 YAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQ 129
Query: 188 PNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWA-------LISQC 240
P TI +F +KR +A Q + + + K + L++ C
Sbjct: 130 PALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNAC 189
Query: 241 IICSVLSTV--------------------AVLLIRTRR---DEVQKYSDTPTTAVALDMF 277
+ S++ + + I+T++ ++V KY D +F
Sbjct: 190 VAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLD-------FSLF 242
Query: 278 KYPVIWLLILWVCFTMLGYVVQVYSLFSFTISLGYTSKQASAVSXXXXXXXXXXRPLVGL 337
K+ + + LG+ + L + G A+ + RP VGL
Sbjct: 243 KHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGL 302
Query: 338 AAD------------KFGAVTTGMFCHLIVAILCYGMWIPCRNYATVVVFGLFEGMLMGS 385
A+ F + G+ CHL+ + ++Y ++V++ +F G+ GS
Sbjct: 303 IANSKYIRPRIQYFFSFAIMFNGV-CHLLCPL--------AQDYTSLVLYAVFFGLGFGS 353
Query: 386 IWLLLTSIITRLVGLPKLEAVYSVVWMFLGVCAIVSPVIGISLAKNNVKPGENAYLYTAV 445
+ +L + LVG P+ + +V + ++ P + L GE Y+Y +
Sbjct: 354 VSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVD---LTGEYKYMYMS- 409
Query: 446 YCGTAYLLAALALWCIRG 463
CG ++ A ++W + G
Sbjct: 410 -CGA--IVVAASVWLLIG 424
>CE29573 [G] KOG2504 Monocarboxylate transporter
Length = 594
Score = 73.2 bits (178), Expect = 9e-13
Identities = 57/205 (27%), Positives = 85/205 (40%), Gaps = 13/205 (6%)
Query: 69 PDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDS-GKYETGGKLDYAAIGGLSFGVG 127
PDGG+GWVVV SF ++ G Y +GV + M+ T L + + GL+ G G
Sbjct: 18 PDGGWGWVVVLGSFFVHVFADGFVYSFGVLVETLMEEFHASNTMAALIISLLTGLTLGSG 77
Query: 128 VLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICF 187
L S + N R G + V L+ F+T +W + +T GV + G G +
Sbjct: 78 PLASAVCN----KYGCRITTITGAGVAFVGCALSYFATAMWHIVITVGVIMGTGFGLMYC 133
Query: 188 PNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALIS------QCI 241
P I +F KRSLA F I+NY + ++ C
Sbjct: 134 PAIVIVTMYFENKRSLATGIAVAGAGVGTVLFAPINAFFINNYGWRSVFLAFLFILVLCA 193
Query: 242 ICSVLSTVAVLLIRTRRDEVQKYSD 266
+C +T A L DE ++ +D
Sbjct: 194 LCG--ATFAPLEFALVPDEEEEVND 216
>Hs22064599 [G] KOG2504 Monocarboxylate transporter
Length = 579
Score = 72.0 bits (175), Expect = 2e-12
Identities = 82/369 (22%), Positives = 143/369 (38%), Gaps = 24/369 (6%)
Query: 69 PDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSY-YMDSGKYETGGKLDYAAIGGLSFGVG 127
PDGG+GWVV ++F +N G SYG L + D ++ D A I L+ V
Sbjct: 141 PDGGWGWVVAAAAFAIN----GLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQ 196
Query: 128 VLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICF 187
SP+ + + R ++ +G V+ ++ + +AF++ L +YL G+ G +
Sbjct: 197 QAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFA 256
Query: 188 PNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALISQCIICSVLS 247
P + +F ++R LA+ + Q ++D + + AL+ I L+
Sbjct: 257 PALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLT 316
Query: 248 TV-AVLLIRTRRDEVQKYSDTPTTAVALDMFKYPVIWLLILWVCFTMLGYVVQVYSLFSF 306
A+LL + +P A+ L +F + L GY V L
Sbjct: 317 PCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPH 376
Query: 307 TISLGYTSKQASAVSXXXXXXXXXXRPLVGLAADKFGAVTTGMFCHLIVAILCYGMWIPC 366
+ G A+ V R + G AD+ G V + A+ G+W+
Sbjct: 377 ALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQ-GWVPLPRLLAVFGALTGLGLWV-- 433
Query: 367 RNYATVVVFGLFE-------------GMLMGSIWLLLTSIITRLVGLPKLEAVYSVVWMF 413
V V G E G+ GS L+ ++ LVG+ + +V M
Sbjct: 434 --VGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMML 491
Query: 414 LGVCAIVSP 422
+ + ++ P
Sbjct: 492 MSLGGLLGP 500
>CE02803 [G] KOG2504 Monocarboxylate transporter
Length = 808
Score = 71.2 bits (173), Expect = 3e-12
Identities = 41/138 (29%), Positives = 67/138 (47%), Gaps = 3/138 (2%)
Query: 67 KVPDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDYAAIGGLSFGV 126
+ PDGGYGWV+VF++F+ N G S + + Y + +Y+ L IG L G
Sbjct: 82 QAPDGGYGWVIVFAAFMSNLVVDGISTAFSEFKQSYKE--RYQESDGLT-VFIGSLIIGT 138
Query: 127 GVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAIC 186
+L PL + + R ++ G +I +A ++A S ++ L GV +G G I
Sbjct: 139 YLLVGPLVSALCNKYEQRYVVMAGGLISGIAFMIAPASPNIYVFMLIYGVMGGLGFGMIY 198
Query: 187 FPNTTIAAPWFRKKRSLA 204
P + +F KR++A
Sbjct: 199 LPAIVVVGFYFDSKRAMA 216
>CE12336 [G] KOG2504 Monocarboxylate transporter
Length = 596
Score = 70.9 bits (172), Expect = 4e-12
Identities = 58/229 (25%), Positives = 101/229 (43%), Gaps = 17/229 (7%)
Query: 44 EKEQTIYEFETVPEDEDDSYNKIKVPDGGYGWVVVFSSFLLNFCTSGASYGYGVYL--SY 101
EK + ETV ++ +D+ I PDGGYGW +V +SFLLN G + G L ++
Sbjct: 10 EKAAAHQDPETVEKELEDA-GFIAPPDGGYGWAIVAASFLLNMIVDGVIFTVGKILQPAW 68
Query: 102 YMDSGKYETGGKLDYAAIGGLSFGVGVLFSPLYNYILINTSPRKLISLGIVIQNVAALLA 161
G E + + + G F G + S L N R++ G +I + LL+
Sbjct: 69 VHSFGISEASAAMTMSILSGCYFFAGPIASVLCNVF----GCRQVALAGSLIAALGFLLS 124
Query: 162 AFSTKLWQVYLTQGVFISIGTGAICFPNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNL 221
+ ++ +Y++ G+ G G + P I + +F KKRS+A F L
Sbjct: 125 ISAPNIYVLYVSFGLIAGAGFGMMYLPAIVIISQYFAKKRSVATGIAVCGSGIGTTVFAL 184
Query: 222 STQRIIDNYDSKWALISQCIICSVLSTVA-----VLL--IRTRRDEVQK 263
+ D W Q ++ + T++ +LL ++ +D+++K
Sbjct: 185 LNDVVWDFVGGDW---KQFLVYTAAVTISGLGACILLRPLKPSKDQIEK 230
>Hs5730045 [G] KOG2504 Monocarboxylate transporter
Length = 613
Score = 66.6 bits (161), Expect = 8e-11
Identities = 88/391 (22%), Positives = 151/391 (38%), Gaps = 36/391 (9%)
Query: 37 LKDPGRLEK----EQTIYEFETVPEDEDDSYNK-IKVPDGGYGWVVVFSSFLLNFCTSGA 91
L DP L + + ++E E P E + + P+GG+GWVVVF++ N G
Sbjct: 132 LPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGI 191
Query: 92 SYGYGVYLSYYMDSGKYETGGKLDYAA--IGGLSFGVGVLFSPLYNYILINTSPRKLISL 149
G+ S ++ K E ++++ A +G L+ G+ SP+ + R +
Sbjct: 192 HNSVGILYSMLLEEEK-EKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATA 250
Query: 150 GIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICFPNTTIAAPWFRKKRSLALXXXX 209
G + + ++F++ L Y T G+ G P+ I +F+++ LA
Sbjct: 251 GAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLA----N 306
Query: 210 XXXXXXXXXFNLSTQRIIDNYDSKWALISQCIICSVLSTVAVLLIRTRRDEVQKYSDTPT 269
F++S +I K L + S V +LL T R + DTP+
Sbjct: 307 GVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPSSQDTPS 366
Query: 270 TAVALDMFKYPVIWLLILWVCFTMLGYVVQVYSLFSFTI---SLGYTSKQASAVSXXXXX 326
+ + +L L F M + + Y +++F I +LGY +
Sbjct: 367 KRGVRTLHQR---FLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEE 423
Query: 327 XXXXXRPLVGL----AADKFGAVTTGMFCHLI----------VAILCYG---MWIP-CRN 368
V L A G + +G I ++ L G M IP CR+
Sbjct: 424 FSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRD 483
Query: 369 YATVVVFGLFEGMLMGSIWLLLTSIITRLVG 399
+ ++V LF G+ G ++ I LVG
Sbjct: 484 FGGLIVVCLFLGLCDGFFITIMAPIAFELVG 514
>Hs20559959 [G] KOG2504 Monocarboxylate transporter
Length = 426
Score = 65.9 bits (159), Expect = 1e-10
Identities = 72/359 (20%), Positives = 135/359 (37%), Gaps = 14/359 (3%)
Query: 69 PDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDYAAIGGLSFGVGV 128
PDGG+GWVVV S+F + G +GV+ ++ + + + A+IG V
Sbjct: 8 PDGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIG---IAVQQ 64
Query: 129 LFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICFP 188
SP+ + + PR ++ G ++ + LLA+F+T L +YL+ G+ G P
Sbjct: 65 FGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAP 124
Query: 189 NTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALISQCIICSVLST 248
+ +F ++RSLA F Q ++ +Y + +L+ + L
Sbjct: 125 TLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSALSLHLVA 184
Query: 249 VAVLLIRTRRDEVQKYSDTPTTAVAL----DMFKYPVIWLLILWVCFTMLGYVVQVYSLF 304
LL E +L +Y V LI GY + L
Sbjct: 185 CGALLRPPSLAEDPAVGGPRAQLTSLLHHGPFLRYTVALTLI------NTGYFIPYLHLV 238
Query: 305 SFTISLGYTSKQASAVSXXXXXXXXXXRPLVGLAADKF-GAVTTGMFCHLIVAILCYGMW 363
+ L + A+ + R + G D G VT + + + ++
Sbjct: 239 AHLQDLDWDPLPAAFLLSVVAISDLVGRVVSGWLGDAVPGPVTRLLMLWTTLTGVSLALF 298
Query: 364 IPCRNYATVVVFGLFEGMLMGSIWLLLTSIITRLVGLPKLEAVYSVVWMFLGVCAIVSP 422
+ +V + G G++ L S++ L+G ++ ++ M + ++ P
Sbjct: 299 PVAQAPTALVALAVAYGFTSGALAPLAFSVLPELIGTRRIYCGLGLLQMIESIGGLLGP 357
>Hs7019529 [G] KOG2504 Monocarboxylate transporter
Length = 504
Score = 64.7 bits (156), Expect = 3e-10
Identities = 81/389 (20%), Positives = 151/389 (37%), Gaps = 40/389 (10%)
Query: 69 PDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYE-TGGKLDYAAIGGLSFGVG 127
PDGG+GWVV+ + F++ +G +YG+ +S + + + G D A + + +
Sbjct: 13 PDGGWGWVVLGACFVV----TGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAML 68
Query: 128 VLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICF 187
P+ + ++ R ++ G ++ + +LA+F+T+L ++YLT GV +G
Sbjct: 69 YGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQ 128
Query: 188 PNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSK------WALISQCI 241
P+ + +F ++R LA + Q++++ + + L+ C
Sbjct: 129 PSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCC 188
Query: 242 IC-SVLSTVAVLLIRTRRDEV-QKYSDTPTTAVA---------LDMFKYPVIWLLILWVC 290
C +V+ R RRD + D P A A + P LL L VC
Sbjct: 189 ACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPWVRPRRRLLDLAVC 248
Query: 291 ------------FTM-LGYVVQVYSLFSFTISLGYTSKQASAVSXXXXXXXXXXRPLVGL 337
F M LG V L ++ G A+ + RP G
Sbjct: 249 TDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGA 308
Query: 338 AADKFGAVTTGMFCHLIVAILCYGMW----IPCRNYATVVVFGLFEGMLMGSIWLLLTSI 393
A + + +A+L G+ R+Y +V F + G+ G + L +
Sbjct: 309 LAG-LARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEV 367
Query: 394 ITRLVGLPKLEAVYSVVWMFLGVCAIVSP 422
+ VG P+ + +V + ++ P
Sbjct: 368 LMAAVGAPRFPSALGLVLLVEAAAVLIGP 396
>YOR306c [G] KOG2504 Monocarboxylate transporter
Length = 521
Score = 63.9 bits (154), Expect = 5e-10
Identities = 88/429 (20%), Positives = 161/429 (37%), Gaps = 40/429 (9%)
Query: 57 EDEDDSYNKIK-VPDGGY-GWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKL 114
+ E+DS +I+ P+GG+ WVV F FL G GV S+ D+ +L
Sbjct: 87 DKEEDSNEEIESFPEGGFKAWVVTFGCFLGLIACFGLLNSTGVIESHLQDN-------QL 139
Query: 115 DYAAIGGLSFGVGV-LFSPLYNYILINT-----SPRKLISLGIVIQNVAALLAAFSTKLW 168
++ + + + LF + I+ T R ++ +G V A STK W
Sbjct: 140 SSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYW 199
Query: 169 QVYLTQGVFISIGTGAICFPNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIID 228
L+ + G G + P ++ A +F K+R AL F + +
Sbjct: 200 HFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFS 259
Query: 229 -------NYDSKWALISQCIICSVLSTVAVLLIRTRRDEVQKYSDTPTTAVALDMFKY-- 279
Y W + + + L T++++L++ R V + S + + Y
Sbjct: 260 MKSDTDPTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRVYIL 319
Query: 280 ---PVIWLLILWVCFTMLGYVVQVYSL-------FSFTISLGYTSKQASAVSXXXXXXXX 329
L + F +LG V S+ S+ S G ++ A +
Sbjct: 320 QCFDAKAFLDMKYLFCVLGTVFSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGI 379
Query: 330 XXRPLVGLAADKFGAVTTGMFCHLIVAILCYGMWIPC-RNYATVVVFGLFEGMLMGSIWL 388
R + G +DKFG + L + I+ + W+P N + V G GS++
Sbjct: 380 PGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFS 439
Query: 389 LLTSIITRLVGLPKLEAVYSVVWMFLGVCAIVS-PVIGISLAKNNVKPGENAYLYTAVYC 447
LL ++ + YS ++ +G +V P+ G ++ Y + ++
Sbjct: 440 LLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIKTTAD----YQHYIIFS 495
Query: 448 GTAYLLAAL 456
G A ++A+
Sbjct: 496 GLATFVSAV 504
>7295764 [G] KOG2504 Monocarboxylate transporter
Length = 1131
Score = 62.4 bits (150), Expect = 2e-09
Identities = 43/184 (23%), Positives = 86/184 (46%), Gaps = 10/184 (5%)
Query: 23 ATSLETSNISSAGELKDPGRLEKEQTIYEFETVPEDEDDSYNKIKV-----PDGGYGWVV 77
AT+ S+I+ + PG ++E + +P + ++ PDGG+GW++
Sbjct: 361 ATTPHPSHITDEEDSAFPGLADREFHLLH-RNIPALRRTGVDTTRIRQYFYPDGGWGWII 419
Query: 78 VFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDYAAIGGLSFGVGVLFSPLYNYI 137
SFL++ T+G YG+ L +Y + T G +G LS+ V ++ + +
Sbjct: 420 CGVSFLVHILTTGLQLSYGL-LWFYAVQYLHNTSG---IELLGALSWSVSMVATSFVVSL 475
Query: 138 LINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICFPNTTIAAPWF 197
S R L +G ++ + L +F+T+ QV + G+ +G + +T + +F
Sbjct: 476 CRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREASTVMLGNYF 535
Query: 198 RKKR 201
+++R
Sbjct: 536 KRRR 539
>Hs18699730 [G] KOG2504 Monocarboxylate transporter
Length = 515
Score = 60.8 bits (146), Expect = 5e-09
Identities = 77/373 (20%), Positives = 128/373 (33%), Gaps = 17/373 (4%)
Query: 69 PDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDY--AAIGGLSFGV 126
P+GG+GW+V+ ++ N G GV +++ + K+ + A +G LS G+
Sbjct: 65 PEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGM 124
Query: 127 GVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAIC 186
P+ + RK +G + V + ++F + + +YLT G+ + G
Sbjct: 125 IFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAY 184
Query: 187 FPNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALISQCIICSVL 246
P+ I +F+K+ L L + +ID+ + L CI VL
Sbjct: 185 QPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVL 244
Query: 247 ----STVAVLLIRTRRDE---------VQKYSDTPTTAVALDMFKYPVIWLLILWVCFTM 293
T L T+ E +K P +FK + + + +
Sbjct: 245 FLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLAL 304
Query: 294 LGYVVQVYSLFSFTISLGYTSKQASAVSXXXXXXXXXXRPLVGLAADKFGAVTTGMFCHL 353
GY V L K V R L G AD V L
Sbjct: 305 FGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVL 364
Query: 354 -IVAILCYGMWIP-CRNYATVVVFGLFEGMLMGSIWLLLTSIITRLVGLPKLEAVYSVVW 411
I M IP C + ++ L G+ G ++ I LVG + +
Sbjct: 365 SFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLL 424
Query: 412 MFLGVCAIVSPVI 424
F+ + V P I
Sbjct: 425 GFMSIPMTVGPPI 437
>Hs4759118 [G] KOG2504 Monocarboxylate transporter
Length = 523
Score = 60.1 bits (144), Expect = 8e-09
Identities = 38/137 (27%), Positives = 68/137 (48%), Gaps = 3/137 (2%)
Query: 67 KVPDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDYAAIGGLSFGV 126
+VPDGG+GW V S F + T G +GV+ + MDS E+ ++ + I + V
Sbjct: 17 EVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFN-ESNSRISW--IISICVFV 73
Query: 127 GVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAIC 186
+PL + R ++ LG ++ + + A+FS ++ +Y+ G+ +G
Sbjct: 74 LTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSF 133
Query: 187 FPNTTIAAPWFRKKRSL 203
P TI + +F K+RS+
Sbjct: 134 LPTVTILSQYFGKRRSI 150
>YOL119c [G] KOG2504 Monocarboxylate transporter
Length = 501
Score = 59.7 bits (143), Expect = 1e-08
Identities = 83/377 (22%), Positives = 129/377 (34%), Gaps = 13/377 (3%)
Query: 69 PDGGY-GWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDYAAIGGLSFGVG 127
PDGG W+VVF +F+ G G SY + + + I L +
Sbjct: 90 PDGGLKAWLVVFGAFMGLVPVFGLINSLGAIESY-ISKHQLANISSSTISWIFSLYLAIS 148
Query: 128 VLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICF 187
L L L+ G VI A +WQ L V +GTG +
Sbjct: 149 FLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMT 208
Query: 188 PNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALISQCIICSVLS 247
P A WF K+R +A F + +++ +WA+ IC
Sbjct: 209 PLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCL 268
Query: 248 TVAVLLIRTR-RDEVQKYSDTPTTAVALDMFKYPVIWLLILWVCFTMLGYVVQVYS---- 302
A +L R R + VQ + A + + L F +G S
Sbjct: 269 ICASVLARERTKPVVQPFKSKAEVAKWYISSVFNWRYFLEGKFLFVAIGASFAESSLTSC 328
Query: 303 ---LFSFTISLGYTSKQASAVSXXXXXXXXXXRPLVGLAADKF-GAVTTGMFCHLIVAIL 358
L S++++ G T A + R + G ADKF G + + A+
Sbjct: 329 ATYLASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALF 388
Query: 359 CYGMWIPCRNYATVV-VFGLFEGMLMGSIWLLLTSIITRLVGLPKLEAVYSVVWMFLGVC 417
+ MW+P V+ + G GSI L I ++ Y+ V++ +
Sbjct: 389 NFVMWLPFGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALV 448
Query: 418 AI-VSPVIGISLAKNNV 433
I V P+ G + K V
Sbjct: 449 TIPVLPIGGTLIGKGTV 465
>CE05457 [G] KOG2504 Monocarboxylate transporter
Length = 807
Score = 55.8 bits (133), Expect = 1e-07
Identities = 47/206 (22%), Positives = 87/206 (41%), Gaps = 14/206 (6%)
Query: 10 SENNTTFREKGEAATSLETSNISSAGELKDPGRLEKEQTIYEFET---VPEDEDDS---- 62
SE+ T R + T ++ ++S E ++ FE V DDS
Sbjct: 33 SESEMTARRRPSMRTRMKAEDVSCWVEHNQQPFSPSDEPRVRFEAPAPVSARSDDSDAES 92
Query: 63 ----YNKIKVPDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDYAA 118
+ DGGYGW+VV +SFL++ GAS+ +G+ ++ ++ G+
Sbjct: 93 VESLTERPVYKDGGYGWLVVLASFLMHAVCDGASFCFGI---VFVKIQEHFQCGRFVSMI 149
Query: 119 IGGLSFGVGVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFI 178
+ + ++ SP+ + R I +G I V+ ++A F + ++ ++ G+
Sbjct: 150 TASMFLSLPLIMSPVAGIVSDILGCRMSIIIGASICTVSCIIAMFCSHIFFFMISFGLGC 209
Query: 179 SIGTGAICFPNTTIAAPWFRKKRSLA 204
+G I I +F K+R LA
Sbjct: 210 GVGMSFIYNAAIVIVTYYFEKRRGLA 235
>7299667 [G] KOG2504 Monocarboxylate transporter
Length = 571
Score = 55.1 bits (131), Expect = 2e-07
Identities = 93/444 (20%), Positives = 158/444 (34%), Gaps = 39/444 (8%)
Query: 69 PDGGY-GWVVVFSSFLLNFCTSGASYGYGVYLSYYMDS----GKYETGGKLDYAAIGGLS 123
PDGG W+V+ S+FL N G YGV S D G E K A IG L+
Sbjct: 33 PDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKA--ALIGALA 90
Query: 124 FGVGVLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTK-LWQVYLTQGVFISIGT 182
G LFS + + R G V+ LL++F T+ + +Y T G+ +G
Sbjct: 91 IGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGA 150
Query: 183 GAICFPNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALISQCII 242
P I +F++ L F + +D + L I
Sbjct: 151 ALAYTPTLAILGHYFKR----YLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRI 206
Query: 243 CSVLSTVAVL---LIRTRRDEVQKYSDTP---------TTAVALDMFKYPVIWLLILWVC 290
S++S +L + + + P + + ++++K + L V
Sbjct: 207 MSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRINLFLRSIINVEIWKRKRFVIWALCVP 266
Query: 291 FTMLGYVVQVYSLFSFTISLGYTSKQASAVSXXXXXXXXXXRPLVGLAADKFGAVTTGMF 350
+ GY V + F + + + + R + G+ AD G +
Sbjct: 267 LALFGYFVPYVHMMQF-VKTTFPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQ 325
Query: 351 CHLIVAILCYGMWIPCRN-YATVVVFGLFEGMLMGSIWLLLTSIITRLVGLPKLEAVYSV 409
+V+I + +P N Y +V F L G+ G LL I + G
Sbjct: 326 QLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICG---PSGATQA 382
Query: 410 VWMFLGVCAIV----SPVIGISLAKNNVKPGENAYLYTAVYCGTAYLLAALALWCIRGII 465
+ LG+ +I PV G+ + N+Y + G LL + L+ I+ +
Sbjct: 383 IGFLLGLSSIPLTVGPPVAGM------IFDSTNSYTLPLILAGLPPLLGSSLLFLIKCVK 436
Query: 466 IARDKVSLVEKTGYDDGELHLRVN 489
+ VS +G++ + N
Sbjct: 437 EEENGVSAPRAVVLANGDIEIAGN 460
>7303008 [G] KOG2504 Monocarboxylate transporter
Length = 471
Score = 53.9 bits (128), Expect = 6e-07
Identities = 40/172 (23%), Positives = 72/172 (41%), Gaps = 5/172 (2%)
Query: 68 VPDGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYETGGKLDYAAIGGLSFGVG 127
VPDGGYGW+VV + L+N +G + + +T + L+
Sbjct: 9 VPDGGYGWIVVAAVALINMTNQSILSVFGQLFVGELQKMQEDTFTAALITNLNSLALNFS 68
Query: 128 VLFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICF 187
LF + + PR + + G ++ + L AF+++ W L F+ G G I
Sbjct: 69 GLF---IGPAIKSFKPRNVAATGCILVALGLALCAFASESWHFILGYSFFVGFGLGLIS- 124
Query: 188 PNTTIAA-PWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSKWALIS 238
P+T +A +F KR A+ + ++DN+ ++A++S
Sbjct: 125 PSTFMAINSYFTTKRGRAVGVSLAGAGLGQVLIPHLVRYLLDNHGFRYAVLS 176
>7303213 [G] KOG2504 Monocarboxylate transporter
Length = 678
Score = 52.4 bits (124), Expect = 2e-06
Identities = 45/180 (25%), Positives = 73/180 (40%), Gaps = 5/180 (2%)
Query: 26 LETSNISSAGELKDPGRLEKEQTIYEFETVPEDEDDSYNKIKVPDGGYGWVVVFSSFLLN 85
+ T S EL G + K+ + E E+E + + PD G+ WVV+ +SFL
Sbjct: 1 MATQQTKSQDELASKGLVSKQPENIKEENEGEEEIEEAAVVVPPDSGWAWVVMVASFLCC 60
Query: 86 FCTSGASYGYGVYLSYYMDSGKYETGGKLDYAA-IGGLSFGVGVLFSPLYNYILINTSPR 144
G + G+ M E G Y A + L G ++ P + + R
Sbjct: 61 TVIDGIVFCSGLIQEQLM----AEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFR 116
Query: 145 KLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICFPNTTIAAPWFRKKRSLA 204
+ G + + L+ F+T + ++L GV IG + P I +F K R+LA
Sbjct: 117 PVTITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALA 176
>Hs4759116 [G] KOG2504 Monocarboxylate transporter
Length = 505
Score = 52.0 bits (123), Expect = 2e-06
Identities = 76/419 (18%), Positives = 172/419 (40%), Gaps = 45/419 (10%)
Query: 70 DGGYGWVVVFSSFLLNFCTSGASYGYGVYLSYYMDSGKYE-TGGKLDYAAIGGLSFGVGV 128
DG + WVV+ ++ + T G + G+ + + ++E + + + V
Sbjct: 9 DGSWAWVVLLATMV----TQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLH 64
Query: 129 LFSPLYNYILINTSPRKLISLGIVIQNVAALLAAFSTKLWQVYLTQGVFISIGTGAICF- 187
+ PL + ++ R + LG V+ ++ + ++FS L Q+Y T G +G +CF
Sbjct: 65 MAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLG---MCFS 121
Query: 188 --PNTTIAAPWFRKKRSLALXXXXXXXXXXXXXFNLSTQRIIDNYDSK------WALISQ 239
+ T+ +F ++R LA + L ++ +++N + +
Sbjct: 122 FQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLH 181
Query: 240 CIIC-SVLSTVAVLLIRTRRDEVQKYSDTPTTA------------VALDMFKYPVIW-LL 285
C IC +++ VA + ++ +TP +A D+ ++ + +
Sbjct: 182 CCICGAIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCVY 241
Query: 286 ILWVCFTMLGYVVQVYSLFSFTISLGYTSKQASAVSXXXXXXXXXXRPLVGLAADKFGAV 345
IL V +++LG+ + L + + +QA+ + RPL GL A +
Sbjct: 242 ILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFA 301
Query: 346 TTGMFCHLIVAILCYGMWIPCR---NYATVVVFGLFEGMLMGSIWLLLTSIITRLVGLPK 402
+ + + +L + C ++ +V + L + M I L+ ++ +V + +
Sbjct: 302 SHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQ 361
Query: 403 LEAVYSVVWMFLGVCAIVS-PVIGISL-AKNNVKPGENAYLYTAVYCGTAYLLAALALW 459
+ + G+ ++S P+ G+ L A NN ++ V+ +++ L + AL+
Sbjct: 362 FPRALGLFTVLDGLAFLISPPLAGLLLDATNN---------FSYVFYMSSFFLISAALF 411
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.324 0.139 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,251,692
Number of Sequences: 60738
Number of extensions: 1169747
Number of successful extensions: 2732
Number of sequences better than 1.0e-05: 27
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2691
Number of HSP's gapped (non-prelim): 38
length of query: 507
length of database: 30,389,216
effective HSP length: 111
effective length of query: 396
effective length of database: 23,647,298
effective search space: 9364330008
effective search space used: 9364330008
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)