ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0204 good C KOG0069 Energy production and conversion Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0204 68605 69783 393
(393 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL113c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 398 e-111
YGL185c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 92 1e-18
SPBC1773.17c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D... 90 7e-18
7297831 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-... 89 1e-17
7298717 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 88 2e-17
SPACUNK4.10 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-... 88 3e-17
Hs6912396 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 87 3e-17
7296684 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 86 7e-17
YNL274c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 86 1e-16
At2g45630 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 86 1e-16
At4g34200 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isome... 84 4e-16
At1g17740 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isome... 83 6e-16
7298718 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 83 8e-16
CE08497 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-... 82 2e-15
At1g79870 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 82 2e-15
At3g19480 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isome... 78 2e-14
At1g12550 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 77 3e-14
Hs5729974 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isome... 72 2e-12
Hs14744596 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isom... 72 2e-12
CE28436 [K] KOG0067 Transcription factor CtBP 67 5e-11
SPAC186.02c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-iso... 65 2e-10
SPAC186.07c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-iso... 64 4e-10
At5g14780 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 63 9e-10
At1g72190 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 58 2e-08
YIL074c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-... 57 4e-08
YER081w [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-... 57 4e-08
SPCC4G3.01 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isom... 57 4e-08
>YPL113c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 396
Score = 398 bits (1022), Expect = e-111
Identities = 197/399 (49%), Positives = 274/399 (68%), Gaps = 18/399 (4%)
Query: 1 MTMTTKFKILIPRKNKNDIASDSAEFQRIAELVDFQYYELTNSEDFKKFLLSSNIDALWI 60
+T + K +IL+P K + ++AS E++++AE V+F YE++ +DF KFL + I+ W+
Sbjct: 10 VTYSAKPRILVPYKTQWEVASHLPEYRKLAERVEFYKYEMSTKDDFVKFLETHRINGFWL 69
Query: 61 TEEMFVYLEAPSTYLDYFPKSLKLILVPWVGTDFYDAKLLKEKYGISLCNGGPVASENVS 120
TEE F L PS+Y+++FP SLK+ILVPWVG DF D KLL+ K GI+LCN GP A+++V+
Sbjct: 70 TEEFFTVLGNPSSYIEFFPASLKVILVPWVGCDFIDGKLLRSK-GITLCNIGPHAADHVT 128
Query: 121 DLAVFLTLSCFRLTSFWEHSFRFVHRGSIQECRGYIGGTHHDTIPGFALVEGNDDLHKTV 180
+LA+FL +SCFR+TSFWE+ F++V G++++C+ YI ++ + D H
Sbjct: 129 ELAIFLAISCFRMTSFWEYCFKYVENGNVEQCKKYISSDSYEIV--------TDSYH--- 177
Query: 181 SAQQKFPK-----KPEND-KFLNLAKDYKIAGKVMESPTDKNALIVGFGSIGQAIGKKLH 234
+ KFP KP D K ++LA+ Y + GK MESP +K LI+GFGSIGQ IG LH
Sbjct: 178 GQEMKFPSRTDKCKPNKDRKVVHLAEKYTVGGKKMESPMNKKVLILGFGSIGQNIGSNLH 237
Query: 235 TTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDADLIVLALPGTPDTEDIIDKT 294
FNM+I Y KR GP+ +S+L Y A Y +DD W++ADLI+LALP T T +II++
Sbjct: 238 KVFNMSIEYYKRTGPVQKSLLDYNAKYHSDLDDPNTWKNADLIILALPSTASTNNIINRK 297
Query: 295 TLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLDVYKNESDVVDSRFFERWDIT 354
+L CKDGVRIVNVGRG+CI+ED LLDAL+SGKV S GLDV+KNE V RWD+T
Sbjct: 298 SLAWCKDGVRIVNVGRGTCIDEDVLLDALESGKVASCGLDVFKNEETRVKQELLRRWDVT 357
Query: 355 LLPHIGSTVIEILQRQTAATLENIEGFFLKGTGTKYPVN 393
LPHIGSTV +++ +QT TLEN++ F++G KY +N
Sbjct: 358 ALPHIGSTVADMVIKQTLITLENVQDIFVEGGDGKYVLN 396
>YGL185c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 379
Score = 92.4 bits (228), Expect = 1e-18
Identities = 59/203 (29%), Positives = 100/203 (49%), Gaps = 12/203 (5%)
Query: 179 TVSAQQKFPKKPENDKFLNLAKDYKIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTTFN 238
T++A+ K +K A +++ ESP K LI+G GSIG+ + KL
Sbjct: 168 TLTARAKAAEKS------GFAFGHELGNMFAESPRGKKCLILGLGSIGKQVAYKLQYGLG 221
Query: 239 MNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDA---DLIVLALPGTPDTEDIIDKTT 295
M I Y KR+ + + ++ + DE + IV+ LPGTP TE +I++
Sbjct: 222 MEIHYCKRS---EDCTMSQNESWKFHLLDETIYAKLYQFHAIVVTLPGTPQTEHLINRKF 278
Query: 296 LEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLDVYKNESDVVDSRFFERWDITL 355
LE C G+ +VN+GRG ++ + DAL +G++ GLDV+ E ++ + ++
Sbjct: 279 LEHCNPGLILVNLGRGKILDLRAVSDALVTGRINHLGLDVFNKEPEIDEKIRSSDRLTSI 338
Query: 356 LPHIGSTVIEILQRQTAATLENI 378
PH+GS ++ ++ L I
Sbjct: 339 TPHLGSATKDVFEQSCELALTRI 361
>SPBC1773.17c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 185
Score = 89.7 bits (221), Expect = 7e-18
Identities = 65/183 (35%), Positives = 92/183 (49%), Gaps = 8/183 (4%)
Query: 212 PTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFW 271
P K I+G G+IG++ +K+ I Y RN E A+++ S D+
Sbjct: 2 PYGKRVGIIGMGAIGKSFAQKI-LPLGCEIVYHNRNRLEAEEEKRLGASFV-SFDE--LL 57
Query: 272 RDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSA 331
+D+I + P TP T D+I EK KDGV I+N RG+ INED + A+ SGKV A
Sbjct: 58 SSSDVISINCPLTPATHDLISTKEFEKMKDGVYIINTARGAIINEDAFIKAIKSGKVARA 117
Query: 332 GLDVYKNESDVVDSRFFERWD-ITLLPHIGSTVIEILQRQTAATLENIEGFFLKGTGTKY 390
GLDV+ NE ++F+ D +T+ PH G + + L +IE F G T
Sbjct: 118 GLDVFLNEP--TPNKFWLECDKVTIQPHCGVYTNFTVAKTEECVLASIETFLDTGIPTN- 174
Query: 391 PVN 393
PVN
Sbjct: 175 PVN 177
>7297831 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 332
Score = 89.0 bits (219), Expect = 1e-17
Identities = 63/179 (35%), Positives = 82/179 (45%), Gaps = 11/179 (6%)
Query: 215 KNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDA 274
K ++G G IG+ + ++ T I Y PI KA I M E W A
Sbjct: 146 KTLAVLGLGRIGREVAIRMKTWGMRIIGYD----PITTEAEA-KAAGIEKMTLEEIWPLA 200
Query: 275 DLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLD 334
D I + P P T ++I TL KCK GV++VNV RG I+E +LD L+SGKV A D
Sbjct: 201 DYITVHTPLIPATRNLISAETLAKCKQGVKVVNVARGGIIDEQAVLDGLESGKVAGAAFD 260
Query: 335 VYKNE--SDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENIEGFF-LKGTGTKY 390
VY E V + PH+G++ E Q +E E F L GT KY
Sbjct: 261 VYPEEPPKSAVTKALISHPKVVATPHLGASTSE---AQVRVAVEVAEQFIALNGTSPKY 316
>7298717 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 248
Score = 88.2 bits (217), Expect = 2e-17
Identities = 57/185 (30%), Positives = 92/185 (48%), Gaps = 10/185 (5%)
Query: 180 VSAQQKFP---KKPENDKFLNLAKDYKIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTT 236
++A ++F K +NDK+ N ++ + + +S GFG IGQAI K+L
Sbjct: 40 IAASRRFHEGRKTIDNDKWENYHLNWLLGQDIRDSTVG----FYGFGGIGQAIAKRLSGF 95
Query: 237 FNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDADLIVLALPGTPDTEDIIDKTTL 296
+ YT R E + A + D + ++D +V+A P T DT+ + + T
Sbjct: 96 DIDKVLYTTRRRVHKEIEEEFNAKKV---DFDTLLAESDFVVIASPLTKDTQGVFNATAF 152
Query: 297 EKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLDVYKNESDVVDSRFFERWDITLL 356
K K +VN+ RG +N+DDL +AL + ++ SAGLDV E + ++ +L
Sbjct: 153 NKMKQTAVLVNIARGKIVNQDDLYEALKANRIFSAGLDVTDPEPLSPKDKLLTLDNVVVL 212
Query: 357 PHIGS 361
PHIGS
Sbjct: 213 PHIGS 217
>SPACUNK4.10 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 334
Score = 87.8 bits (216), Expect = 3e-17
Identities = 61/173 (35%), Positives = 89/173 (51%), Gaps = 7/173 (4%)
Query: 207 KVMESPTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMD 266
K P K I+G G IG+ + K+ F+M I Y R P+PE A ++ S D
Sbjct: 149 KPSHDPEGKTLGILGLGGIGKTMAKRARA-FDMKIVYHNRT-PLPEEE-AEGAEFV-SFD 204
Query: 267 DEAFWRDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSG 326
D +D++ L LP T II K +K K G+ IVN RG+ ++E L++ALD G
Sbjct: 205 D--LLAKSDVLSLNLPLNAHTRHIIGKPEFQKMKRGIVIVNTARGAVMDEAALVEALDEG 262
Query: 327 KVMSAGLDVYKNESDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENIE 379
V SAGLDV++ E + E + LLPH+G+ +E + A L N++
Sbjct: 263 IVYSAGLDVFEEEPK-IHPGLLENEKVILLPHLGTNSLETQYKMECAVLMNVK 314
>Hs6912396 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 328
Score = 87.4 bits (215), Expect = 3e-17
Identities = 53/149 (35%), Positives = 77/149 (51%), Gaps = 4/149 (2%)
Query: 213 TDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWR 272
T I+G G IGQAI ++L YT R P PE ++A ++ + + A
Sbjct: 152 TQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQ-PRPEEAAEFQAEFVSTPELAA--- 207
Query: 273 DADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAG 332
+D IV+A TP TE + +K +K K+ +N+ RG +N+DDL AL SGK+ +AG
Sbjct: 208 QSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAG 267
Query: 333 LDVYKNESDVVDSRFFERWDITLLPHIGS 361
LDV E + + +LPHIGS
Sbjct: 268 LDVTSPEPLPTNHPLLTLKNCVILPHIGS 296
>7296684 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 325
Score = 86.3 bits (212), Expect = 7e-17
Identities = 50/160 (31%), Positives = 86/160 (53%), Gaps = 4/160 (2%)
Query: 219 IVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDADLIV 278
++GFG IGQ I ++ I+YT R+ P+ A ++ D + R++DLIV
Sbjct: 155 LLGFGRIGQEIAARIVPFKPTEITYTTRSLR-PKEAAAVNARHV---DFDEMLRESDLIV 210
Query: 279 LALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLDVYKN 338
+ TP+T++I + T +K K ++N RG +++ L +AL + ++++AGLDV
Sbjct: 211 VCCALTPETKEIFNATAFQKMKPNCILINTARGGVVDQKALYEALKTKRILAAGLDVTTP 270
Query: 339 ESDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENI 378
E +D + ++ +LPHIGS IE + + T NI
Sbjct: 271 EPLPIDDPLLKLDNVVILPHIGSADIETRKEMSRITARNI 310
>YNL274c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 350
Score = 85.9 bits (211), Expect = 1e-16
Identities = 57/174 (32%), Positives = 88/174 (49%), Gaps = 6/174 (3%)
Query: 212 PTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFW 271
P K I+G G IG+ I ++L N Y R+ E G Y+ E F
Sbjct: 161 PEGKTVGILGLGRIGRCILERLKPFGFENFIYHNRHQLPSEEEHG--CEYVGF---EEFL 215
Query: 272 RDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSA 331
+ +D++ + +P +T +I+ T+EK KDGV IVN RG+ I+E + DAL SGK+ SA
Sbjct: 216 KRSDIVSVNVPLNHNTHHLINAETIEKMKDGVVIVNTARGAVIDEQAMTDALRSGKIRSA 275
Query: 332 GLDVYKNESDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENIEGFFLKG 385
GLDV++ E + + LPH+G+ +E ++ +EN + L G
Sbjct: 276 GLDVFEYEPK-ISKELLSMSQVLGLPHMGTHSVETRKKMEELVVENAKNVILTG 328
>At2g45630 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 327
Score = 85.5 bits (210), Expect = 1e-16
Identities = 80/302 (26%), Positives = 125/302 (40%), Gaps = 63/302 (20%)
Query: 81 SLKLILVPWVGTDFYDAKLLKEKYGISLCNGGPVASENVSDLAVFLTLSCFRLTSFWEHS 140
+L+L++ G D D + + GIS+ N G SE+V+D AV L +
Sbjct: 79 NLRLVVTTSAGVDHVDLVECRRR-GISVANAGSSFSEDVADTAVGLLI------------ 125
Query: 141 FRFVHRGSIQECRGYIGGTHHDTIPGFALVEGNDDLHKTVSAQQKFPKKPENDKFLNLAK 200
D+ + +SA +F K+ +F L
Sbjct: 126 ----------------------------------DVFRRISAANRFVKQ----RFWPLKG 147
Query: 201 DYKIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKAN 260
DY + K+ K IVG GSIG + +L F ISY+ RN Y
Sbjct: 148 DYPLGSKLGR----KRIGIVGLGSIGSKVATRLDA-FGCQISYSSRNRK------PYDVP 196
Query: 261 YIPSMDDEAFWRDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLL 320
Y MD E ++D +++ T +I+K L IVNV RG+ I+E++++
Sbjct: 197 YHYYMDIEEMAANSDALIICCELNEKTLRLINKDVLSALGKRGVIVNVARGAIIDEEEMV 256
Query: 321 DALDSGKVMSAGLDVYKNESDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENIEG 380
L G++ AGLDV+++E + V FE ++ PH +E L+ + NIE
Sbjct: 257 RCLREGEIGGAGLDVFEDEPN-VPKELFELDNVVFSPHSAFMTLEGLEELGKVVVGNIEA 315
Query: 381 FF 382
FF
Sbjct: 316 FF 317
>At4g34200 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 603
Score = 84.0 bits (206), Expect = 4e-16
Identities = 58/182 (31%), Positives = 87/182 (46%), Gaps = 5/182 (2%)
Query: 199 AKDYKIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYK 258
A ++K V S K ++GFG +G + ++ I++ P + +
Sbjct: 185 AGEWKRNKYVGVSLVGKTLAVLGFGKVGTEVARRAKGLGMRVIAHD----PYAPADRAHA 240
Query: 259 ANYIPSMDDEAFWRDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDD 318
DEA AD I L +P TP T I++ T K K GVRIVNV RG I+ED
Sbjct: 241 IGVDLVSFDEAL-ATADFISLHMPLTPTTSKILNDETFAKMKKGVRIVNVARGGVIDEDA 299
Query: 319 LLDALDSGKVMSAGLDVYKNESDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENI 378
L+ ALD+G V A LDV+ E DS+ + +T+ PH+G++ +E + E +
Sbjct: 300 LVRALDAGIVAQAALDVFTKEPPAKDSKLVQHERVTVTPHLGASTMEAQEGVAIEIAEAV 359
Query: 379 EG 380
G
Sbjct: 360 VG 361
>At1g17740 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 624
Score = 83.2 bits (204), Expect = 6e-16
Identities = 57/179 (31%), Positives = 86/179 (47%), Gaps = 6/179 (3%)
Query: 215 KNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDA 274
K ++GFG +G + ++ IS+ LG + S D A
Sbjct: 222 KTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRARALGVD---LVSFDQAI--STA 276
Query: 275 DLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLD 334
D + L +P TP T+ + + T K K GVR++NV RG I+ED L+ ALD+G V A LD
Sbjct: 277 DFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALD 336
Query: 335 VYKNESDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENIEGFFLKGTGTKYPVN 393
V+ E DSR + ++T+ PH+G++ E + E + G LKG + VN
Sbjct: 337 VFCEEPPSKDSRLIQHENVTVTPHLGASTKEAQEGVAIEIAEAVAG-ALKGELSATAVN 394
>7298718 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 598
Score = 82.8 bits (203), Expect = 8e-16
Identities = 47/147 (31%), Positives = 75/147 (50%), Gaps = 3/147 (2%)
Query: 214 DKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRD 273
D GFG IGQA+ K+L + YT RN + + A + D E +
Sbjct: 423 DSTVGFYGFGGIGQAVAKRLMGFDIKRMLYTTRNRVSQDIEERFNAKKV---DFETLLAE 479
Query: 274 ADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGL 333
+D +++A P T +T + + T K K+ +VNVGRG +N+DDL +AL S ++ +AGL
Sbjct: 480 SDFLIIASPLTKETLGLFNATVFNKMKETAVLVNVGRGKIVNQDDLYEALKSNRIFAAGL 539
Query: 334 DVYKNESDVVDSRFFERWDITLLPHIG 360
DV E + + ++ + PH+G
Sbjct: 540 DVMDPEPLPSNDKLLTLDNVVVTPHVG 566
>CE08497 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 322
Score = 81.6 bits (200), Expect = 2e-15
Identities = 55/168 (32%), Positives = 83/168 (48%), Gaps = 22/168 (13%)
Query: 219 IVGFGSIGQAIGKKLHTTFNMNI-----SYTKRNGPIPESVLGYKANYIPSMDDEAFWRD 273
++G G IG + +L F M + TK +A I + E W
Sbjct: 150 VLGLGRIGSEVAVRLQA-FGMKVIGFDPMVTKEQA---------EAKNIELLSLEQIWPQ 199
Query: 274 ADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGL 333
AD I + +P TE++I+K TL KCK GVRI+NV RG +NE DL+++L++G A
Sbjct: 200 ADYITVHVPLIKQTENLINKETLAKCKKGVRIINVARGGIVNEVDLVESLNAGHAKGAAF 259
Query: 334 DVYKNESDVVDSRFFERWDITLL---PHIGSTVIEILQRQTAATLENI 378
DV++ E F E D L+ PH+G++ I+ R + +NI
Sbjct: 260 DVFEQEPPT----FRELIDHPLVIATPHLGASTIDAQLRVASEIADNI 303
>At1g79870 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 313
Score = 81.6 bits (200), Expect = 2e-15
Identities = 53/168 (31%), Positives = 90/168 (53%), Gaps = 9/168 (5%)
Query: 215 KNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDA 274
K+ I+G G IG AI K+ F+ I+Y R + + YK Y P++ D A +++
Sbjct: 145 KSVGIIGLGRIGTAIAKRAEA-FSCPINYYSRT---IKPDVAYK--YYPTVVDLA--QNS 196
Query: 275 DLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLD 334
D++V+A P T T I+D+ ++ ++N+GRG ++E +L+ AL G++ A LD
Sbjct: 197 DILVVACPLTEQTRHIVDRQVMDALGAKGVLINIGRGPHVDEQELIKALTEGRLGGAALD 256
Query: 335 VYKNESDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENIEGFF 382
V++ E V + F ++ LLPH+GS +E + N+E F
Sbjct: 257 VFEQEPHVPE-ELFGLENVVLLPHVGSGTVETRNAMADLVVGNLEAHF 303
>At3g19480 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 588
Score = 78.2 bits (191), Expect = 2e-14
Identities = 52/166 (31%), Positives = 80/166 (47%), Gaps = 5/166 (3%)
Query: 215 KNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDA 274
K ++GFG +G + ++ M++ P + +A + + E A
Sbjct: 186 KTLAVLGFGKVGSEVARRARG-LGMHVITHDPYAPADRA----RAIGVELVSFEVAISTA 240
Query: 275 DLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLD 334
D I L LP T T +++ T K GVRIVNV RG I+E+ LL ALDSG V A LD
Sbjct: 241 DFISLHLPLTAATSKMMNDVTFAMMKKGVRIVNVARGGVIDEEALLRALDSGIVAQAALD 300
Query: 335 VYKNESDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENIEG 380
V+ E V D++ +T PH+G++ +E + + E + G
Sbjct: 301 VFTVEPPVKDNKLVLHESVTATPHLGASTMEAQEGVSIEVAEAVIG 346
>At1g12550 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 323
Score = 77.4 bits (189), Expect = 3e-14
Identities = 80/309 (25%), Positives = 129/309 (40%), Gaps = 67/309 (21%)
Query: 75 LDYFPKSLKLILVPWVGTDFYDAKLLKEKYGISLCNGGPVASENVSDLAVFLTLSCFRLT 134
L + P SL++++ VG D D K + GI + N G S++V+D AV L +S
Sbjct: 69 LSHLP-SLQILVCTSVGIDHIDLAACKRR-GIVITNAGNAFSDDVADCAVGLLISVL--- 123
Query: 135 SFWEHSFRFVHRGSIQECRGYIGGTHHDTIPGFALVEGNDDLHKTVSAQQKFPKKPENDK 194
+ + A ++ + K
Sbjct: 124 -------------------------------------------RRIPAADRYVRSGNWAK 140
Query: 195 FLNLAKDYKIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESV 254
F D+++ KV + K IVG GSIG + K+L + F ISY R+ S
Sbjct: 141 F----GDFQLGSKV----SGKRVGIVGLGSIGSFVAKRLES-FGCVISYNSRSQK-QSSP 190
Query: 255 LGYKANYIPSMDDEAFWRDADLIVLALPGTPDTEDIIDKTTLEKC-KDGVRIVNVGRGSC 313
Y ++ + ++ D++VL T +T I+++ +E KDGV ++NVGRG
Sbjct: 191 YRYYSDILSLAENN------DVLVLCCSLTDETHHIVNREVMELLGKDGV-VINVGRGKL 243
Query: 314 INEDDLLDALDSGKVMSAGLDVYKNESDVVDSRFFERWDITLLPHIGSTVIEILQRQTAA 373
I+E +++ L G + AGLDV++NE V F ++ L PH L
Sbjct: 244 IDEKEMVKCLVDGVIGGAGLDVFENE-PAVPQELFGLDNVVLSPHFAVATPGSLDNVAQI 302
Query: 374 TLENIEGFF 382
L N++ FF
Sbjct: 303 ALANLKAFF 311
>Hs5729974 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 533
Score = 71.6 bits (174), Expect = 2e-12
Identities = 44/151 (29%), Positives = 69/151 (45%), Gaps = 6/151 (3%)
Query: 219 IVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDADLIV 278
I+G G IG+ + ++ + I Y P + G + + E W D I
Sbjct: 150 ILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFG-----VQQLPLEEIWPLCDFIT 204
Query: 279 LALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLDVYKN 338
+ P P T +++ T +CK GVR+VN RG ++E LL AL SG+ A LDV+
Sbjct: 205 VHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVF-T 263
Query: 339 ESDVVDSRFFERWDITLLPHIGSTVIEILQR 369
E D + ++ PH+G++ E R
Sbjct: 264 EEPPRDRALVDHENVISCPHLGASTKEAQSR 294
>Hs14744596 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 533
Score = 71.6 bits (174), Expect = 2e-12
Identities = 44/151 (29%), Positives = 69/151 (45%), Gaps = 6/151 (3%)
Query: 219 IVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDADLIV 278
I+G G IG+ + ++ + I Y P + G + + E W D I
Sbjct: 150 ILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFG-----VQQLPLEEIWPLCDFIT 204
Query: 279 LALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLDVYKN 338
+ P P T +++ T +CK GVR+VN RG ++E LL AL SG+ A LDV+
Sbjct: 205 VHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVF-T 263
Query: 339 ESDVVDSRFFERWDITLLPHIGSTVIEILQR 369
E D + ++ PH+G++ E R
Sbjct: 264 EEPPRDRALVDHENVISCPHLGASTKEAQSR 294
>CE28436 [K] KOG0067 Transcription factor CtBP
Length = 701
Score = 67.0 bits (162), Expect = 5e-11
Identities = 83/317 (26%), Positives = 132/317 (41%), Gaps = 66/317 (20%)
Query: 23 SAEFQRIAELVDFQYYELTNSEDFKKFLLSSNIDALWITEEMFVYLEAPSTYLDYFPKSL 82
S E + ++ + + ++++ + +L+ + AL M+ ++ L+ F K L
Sbjct: 164 SVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVAAL-----MYHSIKLEKEDLEKF-KVL 217
Query: 83 KLILVPWVGTDFYDAKLLKEKYGISLCNGGPVASENVSDLAVFLTLSCFRLTSFWEHSFR 142
K++ G D D K E GI++C+ E+V+D + L L FR T +W
Sbjct: 218 KVVFRIGYGIDNIDVKAATE-LGIAVCHAPGDYVEDVADSTLSLILDLFRRT-YW----- 270
Query: 143 FVHRGSIQECRGYIGGTHHDTIPGFALVEGNDDLHKTVSAQQKFPKKPENDKFLNLAKDY 202
H S E R KT+ A Q N
Sbjct: 271 --HAKSYSETR------------------------KTIGADQVRE---------NAVGSK 295
Query: 203 KIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTK---RNGPIPESVLGYKA 259
K+ G V+ I+G G +G A+G + F ++I + R G + LG++
Sbjct: 296 KVRGSVLG--------ILGCGRVGTAVGLRARA-FGLHIIFYDPFVREGH--DKALGFER 344
Query: 260 NYIPSMDDEAFWRDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDL 319
Y +MD+ F +D I L +T II+ +L +CK GV IVN INE+DL
Sbjct: 345 VY--TMDE--FMSRSDCISLHCNLGDETRGIINADSLRQCKSGVYIVNTSHAGLINENDL 400
Query: 320 LDALDSGKVMSAGLDVY 336
AL +G V A LDV+
Sbjct: 401 AAALKNGHVKGAALDVH 417
>SPAC186.02c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 332
Score = 64.7 bits (156), Expect = 2e-10
Identities = 44/143 (30%), Positives = 68/143 (46%), Gaps = 7/143 (4%)
Query: 201 DYKIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKAN 260
D+ I G + K ++G G IG + K F ++ N P+ L N
Sbjct: 131 DFNIVGLLGCDIHGKTVGVIGTGKIGSNVAKCFKMGFGCDVLAYDIN---PDKKL---EN 184
Query: 261 Y-IPSMDDEAFWRDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDL 319
Y + ++ + AD + L P TP T I++ +L K GV IVN RG I+ L
Sbjct: 185 YGVQFVEQNEVLKKADFLCLHCPLTPSTTHIVNSDSLALMKKGVTIVNTSRGGLIDTKAL 244
Query: 320 LDALDSGKVMSAGLDVYKNESDV 342
+DA+DSG+V +DVY+ E ++
Sbjct: 245 VDAIDSGQVGGCAIDVYEGERNL 267
>SPAC186.07c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 332
Score = 63.9 bits (154), Expect = 4e-10
Identities = 48/196 (24%), Positives = 86/196 (43%), Gaps = 22/196 (11%)
Query: 201 DYKIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTTFNMNISY--TKRNGPIPESVLGYK 258
D+ + G + K ++G G IG + K L F + K N + + + +
Sbjct: 131 DFNLNGLLGHDLHGKTIGLLGTGRIGGLVAKCLKLGFGCEVLAHDIKPNKELEKFGIQF- 189
Query: 259 ANYIPSMDDEAFWRDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDD 318
++ + AD + L P TPDTE ++D+ L K GV+I+N RG ++
Sbjct: 190 ------VEQQEVLAKADFLCLHCPLTPDTEHLVDEKLLASMKKGVKIINTSRGGLVDTKA 243
Query: 319 LLDALDSGKVMSAGLDVYKNE---------SDVVDSRFFERW----DITLLPHIGSTVIE 365
L+ A++SG+V +DVY+ E ++V+ F++ ++ + H E
Sbjct: 244 LVKAIESGQVGGCAMDVYEGERRLFYRDLSNEVIKDTTFQQLANFPNVLVTSHQAFFTAE 303
Query: 366 ILQRQTAATLENIEGF 381
L TL+N+ F
Sbjct: 304 ALSAIAHTTLKNVSDF 319
>At5g14780 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 384
Score = 62.8 bits (151), Expect = 9e-10
Identities = 45/163 (27%), Positives = 77/163 (46%), Gaps = 3/163 (1%)
Query: 220 VGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDADLIVL 279
VG G IG+ + ++L F N+ Y R PE A ++ +++ D+IV+
Sbjct: 203 VGAGRIGKLLLQRLKP-FGCNLLYHDRLQMAPELEKETGAKFVEDLNE--MLPKCDVIVI 259
Query: 280 ALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLDVYKNE 339
+P T T + +K + K K GV IVN RG+ + ++DA++SG + DV+ +
Sbjct: 260 NMPLTEKTRGMFNKELIGKLKKGVLIVNNARGAIMERQAVVDAVESGHIGGYSGDVWDPQ 319
Query: 340 SDVVDSRFFERWDITLLPHIGSTVIEILQRQTAATLENIEGFF 382
D + + + PH T I+ R A T + +E +F
Sbjct: 320 PAPKDHPWRYMPNQAMTPHTSGTTIDAQLRYAAGTKDMLERYF 362
>At1g72190 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 344
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/149 (26%), Positives = 71/149 (46%), Gaps = 7/149 (4%)
Query: 215 KNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSM----DDEAF 270
K I+G+G+IG + K+L F + TKR P S++ + + D F
Sbjct: 164 KTVFILGYGNIGIELAKRLKP-FGSRVIATKRFWPA--SIVDSDSRLVDEKGSHEDIYTF 220
Query: 271 WRDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMS 330
AD++V+ L +T +I++K + K G +VN+ RG IN + L+SG +
Sbjct: 221 AGKADIVVVCLRLNKETAEIVNKEFICSMKKGALLVNIARGGLINYESAFQNLESGHLGG 280
Query: 331 AGLDVYKNESDVVDSRFFERWDITLLPHI 359
G+DV +E + + ++ + PH+
Sbjct: 281 LGIDVAWSEPFDPNDPILKFKNVIITPHV 309
>YIL074c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 469
Score = 57.4 bits (137), Expect = 4e-08
Identities = 46/175 (26%), Positives = 80/175 (45%), Gaps = 20/175 (11%)
Query: 203 KIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYI 262
K+A + E K I+G+G IG + L +++ Y + LG A +
Sbjct: 188 KVAARCWEV-RGKTLGIIGYGHIGSQLSV-LAEAMGLHVLYYDI---VTIMALG-TARQV 241
Query: 263 PSMDDEAFWRDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDA 322
++D+ +D + L +P TP+TE ++ KDG ++N RG+ ++ L+ A
Sbjct: 242 STLDE--LLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQA 299
Query: 323 LDSGKVMSAGLDVYKNE---------SDVVD---SRFFERWDITLLPHIGSTVIE 365
+ + K+ A LDVY +E +D ++ S +I L PHIG + E
Sbjct: 300 VKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEE 354
>YER081w [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 469
Score = 57.4 bits (137), Expect = 4e-08
Identities = 46/175 (26%), Positives = 80/175 (45%), Gaps = 20/175 (11%)
Query: 203 KIAGKVMESPTDKNALIVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYI 262
K+A + E K I+G+G IG + L +++ Y + LG A +
Sbjct: 188 KVAARCWEV-RGKTLGIIGYGHIGSQLSV-LAEAMGLHVLYYDI---VTIMALG-TARQV 241
Query: 263 PSMDDEAFWRDADLIVLALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDA 322
++D+ +D + L +P TP+TE ++ KDG ++N RG+ ++ L+ A
Sbjct: 242 STLDE--LLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQA 299
Query: 323 LDSGKVMSAGLDVYKNE---------SDVVD---SRFFERWDITLLPHIGSTVIE 365
+ + K+ A LDVY +E +D ++ S +I L PHIG + E
Sbjct: 300 VKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEE 354
>SPCC4G3.01 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 466
Score = 57.4 bits (137), Expect = 4e-08
Identities = 46/161 (28%), Positives = 75/161 (46%), Gaps = 23/161 (14%)
Query: 219 IVGFGSIGQAIGKKLHTTFNMNISYTKRNGPIPESVLGYKANYIPSMDDEAFWRDADLIV 278
I+G+G IG + L +++ Y +P LG A + S+ + AD +
Sbjct: 200 IIGYGHIGSQLSV-LAEAMGLHVVYYDI---LPIMPLG-SAKQLSSLPE--LLHRADFVS 252
Query: 279 LALPGTPDTEDIIDKTTLEKCKDGVRIVNVGRGSCINEDDLLDALDSGKVMSAGLDVYKN 338
L +P +P+T+++I K+G ++N RG+ ++ L+DA SGK+ A +DVY +
Sbjct: 253 LHVPASPETKNMISSKEFAAMKEGSYLINASRGTVVDIPALVDASKSGKIAGAAIDVYPS 312
Query: 339 E------SDVVDSRFFERW--------DITLLPHIGSTVIE 365
E VDS W +I L PHIG + E
Sbjct: 313 EPAGNGKDKFVDS--LNSWTSELTHCKNIILTPHIGGSTEE 351
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.138 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,875,687
Number of Sequences: 60738
Number of extensions: 1132689
Number of successful extensions: 2561
Number of sequences better than 1.0e-05: 27
Number of HSP's better than 0.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2513
Number of HSP's gapped (non-prelim): 33
length of query: 393
length of database: 30,389,216
effective HSP length: 108
effective length of query: 285
effective length of database: 23,829,512
effective search space: 6791410920
effective search space used: 6791410920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)