ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0213 check: MH T KOG4269 Signal transduction mechanisms Rac GTPase-activating protein BCR/ABR
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0213 70536 73670 1045
(1045 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL115c [T] KOG4269 Rac GTPase-activating protein BCR/ABR 592 e-169
SPAC26A3.09 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 132 4e-30
Hs13775230 [T] KOG4270 GTPase-activator protein 86 2e-16
Hs22050706 [T] KOG4271 Rho-GTPase activating protein 81 7e-15
Hs11038641 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 79 4e-14
Hs11038639 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 79 4e-14
7290597 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 78 6e-14
Hs20977541 [R] KOG4407 Predicted Rho GTPase-activating protein 78 8e-14
Hs7661882 [T] KOG4270 GTPase-activator protein 77 1e-13
CE20680 [Z] KOG3565 Cdc42-interacting protein CIP4 75 7e-13
CE03768 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 73 2e-12
Hs4757980 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 72 3e-12
Hs4502813 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 72 3e-12
Hs11641401 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 71 8e-12
Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein 70 1e-11
Hs10835201 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 70 1e-11
7294614 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 69 3e-11
YOR127w_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 69 4e-11
Hs5803145 [T] KOG4370 Ral-GTPase effector RLIP76 68 7e-11
7289304 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 67 1e-10
Hs22040999 [Z] KOG3565 Cdc42-interacting protein CIP4 66 3e-10
7293370 [T] KOG4271 Rho-GTPase activating protein 65 6e-10
7300563 [T] KOG4270 GTPase-activator protein 64 2e-09
Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4 63 2e-09
Hs20536040 [T] KOG4270 GTPase-activator protein 63 3e-09
Hs4502221 [T] KOG4271 Rho-GTPase activating protein 62 6e-09
Hs16163690 [Z] KOG3565 Cdc42-interacting protein CIP4 61 8e-09
Hs15147252 [T] KOG4270 GTPase-activator protein 61 1e-08
7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr 61 1e-08
YBR260c [T] KOG1450 Predicted Rho GTPase-activating protein 60 1e-08
SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein 60 1e-08
Hs4757766 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 60 1e-08
CE21517 [T] KOG4270 GTPase-activator protein 59 3e-08
YDR379w_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 59 3e-08
YER155c [T] KOG1450 Predicted Rho GTPase-activating protein 59 4e-08
CE00918 [T] KOG1450 Predicted Rho GTPase-activating protein 59 4e-08
Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 58 7e-08
7295587 [R] KOG4407 Predicted Rho GTPase-activating protein 58 9e-08
Hs7661858 [TZ] KOG2710 Rho GTPase-activating protein 57 1e-07
Hs21361736 [T] KOG4270 GTPase-activator protein 56 3e-07
Hs7662242 [T] KOG4270 GTPase-activator protein 56 3e-07
Hs22045949 [T] KOG1449 Predicted Rho GTPase-activating protein C... 56 3e-07
CE26357 [R] KOG4407 Predicted Rho GTPase-activating protein 56 3e-07
CE16059 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr 55 4e-07
HsM19923515 [T] KOG4270 GTPase-activator protein 55 6e-07
Hs14210510 [T] KOG1450 Predicted Rho GTPase-activating protein 55 6e-07
At1g08340 [T] KOG4270 GTPase-activator protein 54 1e-06
7302107 [T] KOG1452 Predicted Rho GTPase-activating protein 54 1e-06
Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 53 3e-06
At4g03100 [T] KOG4270 GTPase-activator protein 53 3e-06
At3g11490 [T] KOG4270 GTPase-activator protein 53 3e-06
YOR134w [TZ] KOG2710 Rho GTPase-activating protein 52 4e-06
CE06642 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 52 4e-06
CE06641 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 52 4e-06
>YPL115c [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1128
Score = 592 bits (1527), Expect = e-169
Identities = 397/1138 (34%), Positives = 575/1138 (49%), Gaps = 142/1138 (12%)
Query: 21 QYENHIQEKDRNLDYIEKGDSRFTKDRETGPSYDECFKENVKLRXXXXXXXXXXXXXXXX 80
QY +H +KD+++++IEKG +E PSYDE F EN+KL+
Sbjct: 20 QYNDHRSKKDKSIEHIEKGTC---SGKERNPSYDEIFTENIKLKLQVQEYETEIESLEKV 76
Query: 81 XXXXXXNAVPVVNYEQQRLEVETP----KDPTFSLPPRSADRIRHMKDTS---------- 126
N + ++++ ++ D +F LPPRSA+R H+K +
Sbjct: 77 IDMLQKNREASLEVVLEQVQNDSRDSYVNDQSFVLPPRSAERKAHIKSLNLPIPTLSPPL 136
Query: 127 -EQSQVNVYDLKLPRSPATFQLNNQNFQEELKTNTQFEKALKNDHAYESTPATASTKKDP 185
+ S V + P P +N + + N ++ + ++ S P
Sbjct: 137 QQGSDVALETSVTPTVPQIGVTSNTSISRKHLQNMILNDEIEANSSFSS----------P 186
Query: 186 QDAGKDSLATTGIPNNILGSPATSVTYTTSRXXXXXXXXXXXXKPHLKRPKSPATLPNGA 245
+ + + T I + L SPA SVTYTTSR K K KSP L
Sbjct: 187 KIINRSVSSPTKIHSEQLASPAASVTYTTSRITI---------KSPNKGSKSP--LQERL 235
Query: 246 LSPQRANRVTHLINNELHSPLK-------DQFSDVDKDFVDDTASTSGDDITGSFIQM-- 296
SPQ NR+T +INN LHSPLK D+ ++ + + A D + S
Sbjct: 236 RSPQNPNRMTAVINNHLHSPLKASTSNNLDELTESKSQQLTNDAIQKNDRVYSSITSSAY 295
Query: 297 ----------SPAAQRIIKEDET-IMEFSPSSKQNLNKFTDLINKTFGDDDS-------- 337
SP++ +KE E + FSP+SK+ L+ FT L++ +FG++D
Sbjct: 296 TTGTPTSAAKSPSSLLEVKEGENKALGFSPASKEKLDDFTQLLDSSFGEEDLVNTDSKDP 355
Query: 338 -QIKGPPEKESAAAVRPPVFDPPLPRAD-------SKVLASPVMIQNAANNL---TPSGL 386
IK + PP F P + S LASPV++ +N + L
Sbjct: 356 LSIKSTINESLPPPPAPPTFFSPTSSGNIKNSTPLSSHLASPVILNKKDDNFGAQSAKNL 415
Query: 387 SFPQKTDISTHDLLKIVSQDNVXXXXXXXXXXXXXXXXXXXXXXRIQPPN--HHTSSIDM 444
P T + K+ + I N + SS
Sbjct: 416 KKPVLTSSLPNLSTKLSTTSQNASLPPNPPVESSSKQKQLGETASIHSTNTLNTFSSTPQ 475
Query: 445 GS------PYNGEVPQSDSVLHSPNIISDIPLFVQPEDFSTIAVEASSTLYSNPEDASKC 498
GS P+ V SV S + SDIPLFVQPEDF TI +E STLY + ED
Sbjct: 476 GSLKTLRRPHASSVSTVKSVAQS--LKSDIPLFVQPEDFGTIQIEVLSTLYRDNED-DLS 532
Query: 499 ILCSVIDKKSSKEMFKFAKSLDQLYELDHMLKIRLMEQYHLPELPKKQLFQTTVPVKVDL 558
IL ++ID+KS KEMFKF+KS+ ++ ELD +K + + LP LP +QLFQT P KVD
Sbjct: 533 ILIAIIDRKSGKEMFKFSKSIHKVRELDVYMKSHVPD-LPLPTLPDRQLFQTLSPTKVDT 591
Query: 559 RRELLTDYLLALFELSNLSPVMSLKLAQFISTDTAISVPIGMTDSVKEGVLLVRKNKALG 618
R+ +L Y ++F + + LK+AQFISTDT ++ P+ M D+VK+G LL+R+ K L
Sbjct: 592 RKNILNQYYTSIFSVPEFPKNVGLKIAQFISTDTVMTPPM-MDDNVKDGSLLLRRPKTLT 650
Query: 619 SGNSWKVRQAVIEDQTLLLFDQENLVESIKLVSSTIELQANLPDDKYGTKNGFILNEPKK 678
++W+VR ++ D L LFD+ L E+IKL S+IEL NLP+D++GT+NGF++ E KK
Sbjct: 651 GNSTWRVRYGILRDDVLQLFDKNQLTETIKLRQSSIELIPNLPEDRFGTRNGFLITEHKK 710
Query: 679 SGLSSTSRHYFGAETAKQREEWISALIKVC----------------SNSVANIKADTLSS 722
SGLS+++++Y ET+K+RE W+SA ++S +++ A T S
Sbjct: 711 SGLSTSTKYYICTETSKERELWLSAFSDYIDPSQSLSLSSSRNANDTDSASHLSAGTHHS 770
Query: 723 AQDQGXXXXXXXXXXXXXXXGPMVNLEMLGKSQQ--------------------VEPATT 762
N + S
Sbjct: 771 KFGNATISATDTPSYVTDLTQEYNNNNNISNSSNNIANSDGIDSNPSSHSNFLASSSGNA 830
Query: 763 EMDRETKRNRMRSFFPFKK-NQPQLSTSSLDITKESDETSAE------RSFASALHGMNL 815
E +++++R +MRS FPFKK P + + + IT +D S +S + L ++
Sbjct: 831 EEEKDSRRAKMRSLFPFKKLTGPASAMNHIGITISNDSDSPTSPDSIIKSPSKKLMEVSS 890
Query: 816 HDEA-----ISNVVFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFR 870
+ +S +FGS ++ CL LSS YQN +++P+VVYRCLEYLYKNR I EEGIFR
Sbjct: 891 SSNSSTGPHVSTAIFGSSLETCLRLSSHKYQNVYDLPSVVYRCLEYLYKNRGIQEEGIFR 950
Query: 871 LSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLKNGP---YLDVNTVAGLLKLYFRRLP 927
LSGSS +IKTLQE+FDKEYDV+LC YN S E Y+ VNTV+GLLKLY R+LP
Sbjct: 951 LSGSSTVIKTLQERFDKEYDVDLCRYNESIEAKDDEASPSLYIGVNTVSGLLKLYLRKLP 1010
Query: 928 HLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINEN 987
HL+FGD+ + + + + N P + +L F+EL+ + N SLM+ LFELL++INEN
Sbjct: 1011 HLLFGDEQFLSFKRVVDENHNNPVQISLGFKELIESGLVPHANLSLMYALFELLVRINEN 1070
Query: 988 NKVNKMNLRNLCIVFSPTLNIPVNILQPFVEDFQCIFNGSDPVNNDDRQNINLQIPQM 1045
+K NKMNLRNLCIVFSPTLNIP+++LQPF+ DF CIF G +PV ++R+ +++ IPQ+
Sbjct: 1071 SKFNKMNLRNLCIVFSPTLNIPISMLQPFITDFACIFQGGEPVKEEEREKVDIHIPQV 1128
>SPAC26A3.09 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1275
Score = 132 bits (331), Expect = 4e-30
Identities = 93/272 (34%), Positives = 144/272 (52%), Gaps = 24/272 (8%)
Query: 757 VEPATTEMDRETKRNRMRSF-FPFKK--NQPQLSTSSLDITKESDETSAERSFASALHGM 813
++ + E KR+RM+ + FP K N Q+S +++ + ET+ S +S
Sbjct: 995 IDSHSQNSQNEEKRSRMKFWAFPHHKAENYEQISDTNIPVI----ETNVMLSPSSTTSAE 1050
Query: 814 NLHDEAI-SNVVFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLS 872
L + + +FG + +++S++ N +P VVYRC+EYL RA EEGI+RLS
Sbjct: 1051 PLQKHIVRKSGIFGLPLNEAVNISTQF--NDSGLPIVVYRCIEYLESCRAEKEEGIYRLS 1108
Query: 873 GSSALIKTLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFG 932
GS++ IK L+EQF++ D +L L + DV+ +AGLLKLY R LP +
Sbjct: 1109 GSASTIKHLKEQFNEGVDYDL----------LSSDEEFDVHVIAGLLKLYLRNLPTNLLD 1158
Query: 933 DDMYEECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNK 992
M++ + E P ++A + EN++L+ L L +I KVNK
Sbjct: 1159 TSMHK----LFELLPNVPNDSAALGELCDVISKLPPENFALLDSLLHHLRRIIAFEKVNK 1214
Query: 993 MNLRNLCIVFSPTLNIPVNILQPFVEDFQCIF 1024
MN+RN+CIVFSPTLNIP +I + ++ IF
Sbjct: 1215 MNIRNVCIVFSPTLNIPSDIFMMLILNYDHIF 1246
>Hs13775230 [T] KOG4270 GTPase-activator protein
Length = 655
Score = 86.3 bits (212), Expect = 2e-16
Identities = 65/208 (31%), Positives = 104/208 (49%), Gaps = 32/208 (15%)
Query: 824 VFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQE 883
+FG ++ + R Y N P +V +C++++ + R + EEG+FRL G + L+K LQ+
Sbjct: 39 IFGQKLEDTVRYEKR-YGN-RLAPMLVEQCVDFI-RQRGLKEEGLFRLPGQANLVKELQD 95
Query: 884 QFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEE----C 939
FD C S + + DV+TVA LLKLY R LP + YE+
Sbjct: 96 AFD-------CGEKPSFDSN------TDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCA 142
Query: 940 RVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLC 999
+++++ E A Q + L + NY+L+ + L ++ + VNKM+++NL
Sbjct: 143 KLLSKEEEAGVKELAKQVKSL------PVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLA 196
Query: 1000 IVFSPTLNIPVNILQPFVEDFQCIFNGS 1027
VF P NIL+P VED I G+
Sbjct: 197 TVFGP------NILRPKVEDPLTIMEGT 218
>Hs22050706 [T] KOG4271 Rho-GTPase activating protein
Length = 1499
Score = 81.3 bits (199), Expect = 7e-15
Identities = 54/164 (32%), Positives = 91/164 (54%), Gaps = 17/164 (10%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLK 905
IP + RC+EY+ + ++ EGI+R+SG+ + +++LQ QFD++++++L E + +
Sbjct: 1261 IPIFIERCIEYI-EATGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFT------ 1313
Query: 906 NGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKR 965
VNTVAG +K +F LP + +M + + N + AL +E++ K+
Sbjct: 1314 ------VNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHAL--KEVL--KK 1363
Query: 966 FEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIP 1009
F EN+ + + L K++ NNKVN M NL I F PTL P
Sbjct: 1364 FPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRP 1407
>Hs11038641 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1227
Score = 79.0 bits (193), Expect = 4e-14
Identities = 62/201 (30%), Positives = 97/201 (47%), Gaps = 32/201 (15%)
Query: 845 EIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFD---KEYDVNLCEYNASHE 901
++P +V +C+E + + R + E GI+R+SG + I+ L+ FD K+ V + E
Sbjct: 1022 KVPYIVRQCVEEI-ERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSE------ 1074
Query: 902 GSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELV 961
+DVN +AG LKLYFR LP +F D+ Y AE G + +
Sbjct: 1075 --------MDVNAIAGTLKLYFRELPEPLFTDEFYPN---FAE---GIALSDPVAKESCM 1120
Query: 962 SNKRFEMENYSLMFVLFEL--LMKINENNKVNKMNLRNLCIVFSPTLNIPVNILQPFVED 1019
N + +L+ LF L L ++ E VNKM+L NL VF PTL L+P ++
Sbjct: 1121 LNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTL------LRPSEKE 1174
Query: 1020 FQCIFNGSDPVNNDDRQNINL 1040
+ N S P+ D ++ +
Sbjct: 1175 SKLPANPSQPITMTDSWSLEV 1195
>Hs11038639 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1271
Score = 79.0 bits (193), Expect = 4e-14
Identities = 62/201 (30%), Positives = 97/201 (47%), Gaps = 32/201 (15%)
Query: 845 EIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFD---KEYDVNLCEYNASHE 901
++P +V +C+E + + R + E GI+R+SG + I+ L+ FD K+ V + E
Sbjct: 1066 KVPYIVRQCVEEI-ERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSE------ 1118
Query: 902 GSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELV 961
+DVN +AG LKLYFR LP +F D+ Y AE G + +
Sbjct: 1119 --------MDVNAIAGTLKLYFRELPEPLFTDEFYPN---FAE---GIALSDPVAKESCM 1164
Query: 962 SNKRFEMENYSLMFVLFEL--LMKINENNKVNKMNLRNLCIVFSPTLNIPVNILQPFVED 1019
N + +L+ LF L L ++ E VNKM+L NL VF PTL L+P ++
Sbjct: 1165 LNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTL------LRPSEKE 1218
Query: 1020 FQCIFNGSDPVNNDDRQNINL 1040
+ N S P+ D ++ +
Sbjct: 1219 SKLPANPSQPITMTDSWSLEV 1239
>7290597 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 494
Score = 78.2 bits (191), Expect = 6e-14
Identities = 59/183 (32%), Positives = 90/183 (48%), Gaps = 20/183 (10%)
Query: 824 VFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQE 883
VFG+D+ + L H+IP VV RC+E + + R + +EGI+R+SG + I+ L+
Sbjct: 301 VFGTDLTTMVQLEPH-----HQIPFVVRRCVEEV-EARGMLQEGIYRVSGFADEIEALKL 354
Query: 884 QFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIA 943
D+E + + Y +VN +AG LKLY R LP + Y +A
Sbjct: 355 ALDRE----------GEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPS--FMA 402
Query: 944 ERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFS 1003
+GK E E V +R ++S + + E L ++ + VNKMN NL VF+
Sbjct: 403 AGRTGKQAEQRQLMAEAV--RRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFA 460
Query: 1004 PTL 1006
PTL
Sbjct: 461 PTL 463
>Hs20977541 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 1957
Score = 77.8 bits (190), Expect = 8e-14
Identities = 95/417 (22%), Positives = 161/417 (37%), Gaps = 51/417 (12%)
Query: 601 TDSVKEGVLLVR-----KNKALGSG-NSWKVRQAVIEDQTLLLFDQENLVESIKLVSSTI 654
+D+ KEG L R K K +G WK V+ +L L+ + + I
Sbjct: 929 SDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEEEQPI 988
Query: 655 ELQANLPDDKYGT---KNGFILNEPKKSGLSSTSRHYFGAETAKQREEWISALIKVCSNS 711
+ A L D Y KN F L +S F AE WI
Sbjct: 989 SVNACLIDISYSETKRKNVFRLT-------TSDCECLFQAEDRDDMLAWIKT-------- 1033
Query: 712 VANIKADTLSSAQDQGXXXXXXXXXXXXXXXGPMVNLEMLGKS--QQVEPATTEMDRETK 769
I+ + + +D G M E L K+ Q + T + +++
Sbjct: 1034 ---IQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSE 1090
Query: 770 RNRMRSFFPFKKNQPQLSTSSLDITKESDETSAERSFASALHGMNLHDEAISNVVFGSDI 829
P ++++ +L S D T + R ++ + + FG +
Sbjct: 1091 PKTQSPHSPKEESERKLL--SKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRL 1148
Query: 830 KHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEY 889
C + Y IP +V C + L + R + GI+R+ G++A I ++QE+ +K
Sbjct: 1149 DDCPPAHTNRY-----IPLIVDICCK-LVEERGLEYTGIYRVPGNNAAISSMQEELNK-- 1200
Query: 890 DVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGK 949
+ +++ + D+N ++ LLK +FR+LP +F +D Y + I
Sbjct: 1201 --------GMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYAD--FIEANRKED 1250
Query: 950 PTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTL 1006
P + + L+ + +Y + L L + EN++ NKM RNL IVF PTL
Sbjct: 1251 PLDRLKTLKRLIHD--LPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTL 1305
>Hs7661882 [T] KOG4270 GTPase-activator protein
Length = 638
Score = 77.4 bits (189), Expect = 1e-13
Identities = 62/207 (29%), Positives = 96/207 (45%), Gaps = 24/207 (11%)
Query: 824 VFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQE 883
VFG + ++ + H +P +V +C E++ ++ NEEGIFRL G L+K L++
Sbjct: 149 VFGQRLDETVAYEQKF--GPHLVPILVEKCAEFILEHGR-NEEGIFRLPGQDNLVKQLRD 205
Query: 884 QFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIA 943
FD A S DV+TVA LLKLY R LP + YE +
Sbjct: 206 AFD-----------AGERPSFDRD--TDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCG 252
Query: 944 ERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFS 1003
+ + + + + +S +NYSL+ + L +I N VNKM++ NL V
Sbjct: 253 QLTNADEAKAQQELMKQLS--ILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATV-- 308
Query: 1004 PTLNIPVNILQPFVEDFQCIFNGSDPV 1030
I VN+++ VED I G+ +
Sbjct: 309 ----IGVNLIRSKVEDPAVIMRGTPQI 331
>CE20680 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 1059
Score = 74.7 bits (182), Expect = 7e-13
Identities = 59/173 (34%), Positives = 86/173 (49%), Gaps = 16/173 (9%)
Query: 834 SLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNL 893
SL V EIP +V + YL + ++ +G+FR+SGS + I +E +++ D+
Sbjct: 528 SLDEYVEATGEEIPLLVQSAIAYLSRY-SLRNQGLFRVSGSQSEINRFREAYERGEDL-- 584
Query: 894 CEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTET 953
+ +GS D N+ AG+LKLYFR L IF M+E+ A+ S PTE
Sbjct: 585 --FQYLDDGS-------DANSAAGVLKLYFRELREPIFPIFMFEQFCDCAKSES--PTEF 633
Query: 954 ALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTL 1006
+ RELVS + + + L+ LF L + E N M NL I F PTL
Sbjct: 634 VRRARELVS--KLPVSHVLLLRFLFAFLSHLCEFADENMMEPHNLAICFGPTL 684
>CE03768 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 444
Score = 73.2 bits (178), Expect = 2e-12
Identities = 50/166 (30%), Positives = 85/166 (51%), Gaps = 11/166 (6%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLK 905
IP +V + +EYL + A+ EG+FR S + IK LQ++ +K ++ ++ K
Sbjct: 262 IPPIVDQLIEYL-EAHALTMEGVFRKSANIGSIKRLQDRINKGEKIDF-----ENDPEYK 315
Query: 906 NGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKR 965
+ Y+ + LLK +FR L + + +Y + ++E + TE + +E V K
Sbjct: 316 DNEYVASLHASVLLKTFFRSLGEPLTTNRLYPKLAALSEVSK---TEKSAAVKEFV--KL 370
Query: 966 FEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIPVN 1011
ENY L+ + + L ++ EN+KVN M NL +VF P L P +
Sbjct: 371 LPRENYILLKTVIKFLTRVAENSKVNLMTANNLSVVFGPNLTWPTD 416
>Hs4757980 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 468
Score = 72.4 bits (176), Expect = 3e-12
Identities = 58/206 (28%), Positives = 96/206 (46%), Gaps = 24/206 (11%)
Query: 812 GMNLHDEAISNVVFGS--DIK-----HCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAIN 864
G+N+H + +V D+K +C L++ V + + P VV C+ + + R +
Sbjct: 249 GLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREI-EARGLK 307
Query: 865 EEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFR 924
EG++R+SG + I+ ++ FD++ + + Y D+N + G LKLYFR
Sbjct: 308 SEGLYRVSGFTEHIEDVKMAFDRD----------GEKADISANVYPDINIITGALKLYFR 357
Query: 925 RLPHLIFGDDMYEECRVIAE-RNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMK 983
LP + D Y + A+ N+ + E + L+ +E Y ++ L K
Sbjct: 358 DLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIH-----LKK 412
Query: 984 INENNKVNKMNLRNLCIVFSPTLNIP 1009
+ N K N MN NL IVF PTL P
Sbjct: 413 VTMNEKDNFMNAENLGIVFGPTLMRP 438
>Hs4502813 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 459
Score = 72.4 bits (176), Expect = 3e-12
Identities = 60/203 (29%), Positives = 96/203 (46%), Gaps = 24/203 (11%)
Query: 812 GMNLHDEAISNVVFGS--DIKHC-----LSLSSRVYQNTHEIPTVVYRCLEYLYKNRAIN 864
G+N+H + V D+KH L++ V +T + P VV C+ + ++R +N
Sbjct: 240 GLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREI-ESRGLN 298
Query: 865 EEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFR 924
EG++R+SG S LI+ ++ FD++ + + Y D+N + G LKLYFR
Sbjct: 299 SEGLYRVSGFSDLIEDVKMAFDRD----------GEKADISVNMYEDINIITGALKLYFR 348
Query: 925 RLPHLIFGDDMYEECRVIAE-RNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMK 983
LP + D Y + A+ + + ET + +L+ E Y L L +
Sbjct: 349 DLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRY-----LMAHLKR 403
Query: 984 INENNKVNKMNLRNLCIVFSPTL 1006
+ + K N MN NL IVF PTL
Sbjct: 404 VTLHEKENLMNAENLGIVFGPTL 426
>Hs11641401 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 859
Score = 71.2 bits (173), Expect = 8e-12
Identities = 53/170 (31%), Positives = 79/170 (46%), Gaps = 20/170 (11%)
Query: 845 EIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSL 904
++P +V +C+E + K R I E GI+R+SG + I+ L+ FD A+++ L
Sbjct: 659 KVPYIVRQCVEEVEK-RGIEEVGIYRISGVATDIQALKAVFD-----------ANNKDIL 706
Query: 905 KNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQ--FRELVS 962
+D+N +AG LKLYFR LP + D +Y + E + R L
Sbjct: 707 LMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPD 766
Query: 963 NKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIPVNI 1012
N L E L ++ E +NKM+L NL VF PTL P +
Sbjct: 767 ------PNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEV 810
>Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 316
Score = 70.5 bits (171), Expect = 1e-11
Identities = 59/253 (23%), Positives = 117/253 (45%), Gaps = 32/253 (12%)
Query: 759 PATTEMDRETKRNRMRSFFPFKKNQPQLSTSSLDITKESDETSAERSFASALHGMNLHDE 818
P + D+E ++ + FK SS+D +++ + F + + E
Sbjct: 63 PGIEKHDKEKEQKDPKKLRSFK-------VSSIDSSEQKKTKKNLKKFLTRRPTLQAVRE 115
Query: 819 A--ISNVVFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSA 876
I + VFGS+ L++ + +P V C+E++ + ++ +GI+R+SG+ A
Sbjct: 116 KGYIKDQVFGSN------LANLCQRENGTVPKFVKLCIEHV-EEHGLDIDGIYRVSGNLA 168
Query: 877 LIKTLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMY 936
+I+ L+ F +D L L + + D++ + G LK++FR LP +F + +
Sbjct: 169 VIQKLR--FAVNHDEKL---------DLNDSKWEDIHVITGALKMFFRELPEPLFTFNHF 217
Query: 937 EECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLR 996
+ +P + ++L+ ++ N M +LF L ++ EN + N+M +
Sbjct: 218 ND---FVNAIKQEPRQRVAAVKDLI--RQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQ 272
Query: 997 NLCIVFSPTLNIP 1009
++ IVF PTL P
Sbjct: 273 SIAIVFGPTLLKP 285
>Hs10835201 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 822
Score = 70.5 bits (171), Expect = 1e-11
Identities = 53/166 (31%), Positives = 78/166 (46%), Gaps = 16/166 (9%)
Query: 847 PTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLKN 906
P +V +C+E + K R I E GI+R+SG + I+ L+ FD A+++ L
Sbjct: 624 PYIVRQCVEEVEK-RGIEEVGIYRISGVATDIQALKAVFD-----------ANNKDILLM 671
Query: 907 GPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKRF 966
+D+N +AG LKLYFR LP + D +Y + E + LV +
Sbjct: 672 LSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMM--HLV--RSL 727
Query: 967 EMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIPVNI 1012
N L E L ++ E +NKM+L NL VF PTL P +
Sbjct: 728 PDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEV 773
>7294614 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 476
Score = 69.3 bits (168), Expect = 3e-11
Identities = 49/161 (30%), Positives = 79/161 (48%), Gaps = 18/161 (11%)
Query: 844 HEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGS 903
+ IP +V +C++ L I+ EGIFR SG+ + I L+E+ ++ DV+L N
Sbjct: 289 NSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIMALKERVNRGEDVDLKSVN------ 342
Query: 904 LKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSN 963
V+ +AGLLK + R L + ++YE+ + E + +L+
Sbjct: 343 --------VHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLD---WPKEERSRNVTQLIRE 391
Query: 964 KRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSP 1004
K E ENY L + E L+++ + +NKM NL IVF P
Sbjct: 392 KLPE-ENYELFKYIVEFLVRVMDCEDLNKMTSSNLAIVFGP 431
>YOR127w_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 884
Score = 68.9 bits (167), Expect = 4e-11
Identities = 52/191 (27%), Positives = 92/191 (47%), Gaps = 25/191 (13%)
Query: 834 SLSSRVYQNTHEIPTVVYRCLEYLYKNRA-INEEGIFRLSGSSALIKTLQEQFDKEYDVN 892
SL +R +EIP ++ C++++ + + EGI+R SGS +I E+ +K++
Sbjct: 669 SLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVI----EEIEKQFSAW 724
Query: 893 LCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEE-CRVIAERN----- 946
+ N L D+N V G+LK Y R+LP+ IF +YE R++ +
Sbjct: 725 KVQQNTETPNILTEQ---DLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMENL 781
Query: 947 ---------SGKPTETALQFRELVSN--KRFEMENYSLMFVLFELLMKINENNKVNKMNL 995
K ++T + + + N + E+Y ++ VL E + K+ + N+M L
Sbjct: 782 PFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTL 841
Query: 996 RNLCIVFSPTL 1006
NL +VF+P L
Sbjct: 842 YNLALVFAPGL 852
>Hs5803145 [T] KOG4370 Ral-GTPase effector RLIP76
Length = 655
Score = 68.2 bits (165), Expect = 7e-11
Identities = 52/179 (29%), Positives = 82/179 (45%), Gaps = 19/179 (10%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLK 905
+P V C++Y+ K + EGI+R+SG + + L+ +D+E NL +Y
Sbjct: 209 LPAVFRECIDYVEKY-GMKCEGIYRVSGIKSKVDELKAAYDREESTNLEDY--------- 258
Query: 906 NGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKR 965
+ NTVA LLK Y R LP + ++ R + TE +F+ L+ K
Sbjct: 259 -----EPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTT--ETEKVQEFQRLL--KE 309
Query: 966 FEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIPVNILQPFVEDFQCIF 1024
NY L+ L + + KMN++N+ IV SPT+ I +L F Q +F
Sbjct: 310 LPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELF 368
>7289304 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 718
Score = 67.0 bits (162), Expect = 1e-10
Identities = 54/190 (28%), Positives = 97/190 (50%), Gaps = 20/190 (10%)
Query: 824 VFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQE 883
+FG+ + L R +IP ++ C+ + + R + E G +R+SGS++ + L++
Sbjct: 509 LFGAKMSQVLKREKR------DIPFIIGACIREV-ERRGMLEVGCYRVSGSASDLAKLKK 561
Query: 884 QFDK-EYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVI 942
F+ EY + Y A E L+ +D+++V G+LK + R LP +F D +Y R
Sbjct: 562 AFESGEYMALMDAYEA--EQLLRE---VDIHSVTGILKTFLRELPEALFTDQLYP--RFF 614
Query: 943 AERNSGKPTETALQFRELVSNKRFE---MENYSLMFVLFELLMKINENNKVNKMNLRNLC 999
++ + + EL+ K FE N + + + + L++++E NKM+L NL
Sbjct: 615 DTFSAFSNNNESTRINELL--KVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLA 672
Query: 1000 IVFSPTLNIP 1009
+VF PTL P
Sbjct: 673 MVFGPTLLRP 682
>Hs22040999 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 918
Score = 65.9 bits (159), Expect = 3e-10
Identities = 47/173 (27%), Positives = 86/173 (49%), Gaps = 16/173 (9%)
Query: 834 SLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNL 893
S + R ++ IP VV C+ ++ ++ + EGIFR+SGS + ++ F++ D
Sbjct: 339 SSTVRKQDSSQAIPLVVESCIRFISRH-GLQHEGIFRVSGSQVEVNDIKNAFERGEDPLA 397
Query: 894 CEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTET 953
+ N D++++AG+LKLYFR L H +F D++ + ++ + E
Sbjct: 398 GDQNDH-----------DMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQ--ER 444
Query: 954 ALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTL 1006
AL R+++ +M LF L +++ ++ N M+ NL I F P+L
Sbjct: 445 ALHIRKVL--LVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSL 495
>7293370 [T] KOG4271 Rho-GTPase activating protein
Length = 553
Score = 65.1 bits (157), Expect = 6e-10
Identities = 57/210 (27%), Positives = 107/210 (50%), Gaps = 41/210 (19%)
Query: 845 EIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSL 904
EIP + +C+E++ K ++ EGI+R+ GS A + L ++F+++ + + +
Sbjct: 354 EIPIFLNKCVEFIEKE-GLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALD------- 405
Query: 905 KNGPYLDVNTVAGLLKLYF-RRLPHLIFGDDMYEECRVIA--------ERNSGKPTETAL 955
+ VN VA LK +F +RLP L F D+ +E IA + N T+ +
Sbjct: 406 -----IPVNAVATALKDFFSKRLPPL-FSKDIIKELEEIAGSRGVGNSKLNVEVKTDRSC 459
Query: 956 QFRELVSN-KRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIPVNI-- 1012
+ L S ++ N++++ +F+ + +++N+K+N M+ +NL I + PTL IP++
Sbjct: 460 RLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTL-IPIDFTD 518
Query: 1013 ------LQPFVED--------FQCIFNGSD 1028
L+P++ED F +F G D
Sbjct: 519 MGHFEQLRPYLEDIVQTMIDQFPYLFCGKD 548
>7300563 [T] KOG4270 GTPase-activator protein
Length = 740
Score = 63.5 bits (153), Expect = 2e-09
Identities = 58/234 (24%), Positives = 104/234 (43%), Gaps = 41/234 (17%)
Query: 793 ITKESDETSAERSFASALHGMNLHDEAISNVV-----------------FGSDIKHCLSL 835
I KE + S R + L+ N H+ A+ +V FG+ +K L+
Sbjct: 202 IAKEDEIVSCIRDYV--LNQRNYHERALQHVNASLARIQDTIQGTEKSRFGTSLKEHLTS 259
Query: 836 SSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCE 895
++R EI +V C L ++ + EEG+ R+ +S ++ ++ +
Sbjct: 260 TNR------EISYIVELCCCCLLEH-GLEEEGLLRVGCASTKLRRMKHALE--------- 303
Query: 896 YNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETAL 955
A H + Y D + + +LKLY R LP + ++Y++ IAER+S +T +
Sbjct: 304 --AQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEI 361
Query: 956 QFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIP 1009
+ + ENY+ + L L + + + +NKM+ +NL IV SP + P
Sbjct: 362 K----AILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWP 411
>Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 946
Score = 63.2 bits (152), Expect = 2e-09
Identities = 54/189 (28%), Positives = 92/189 (48%), Gaps = 27/189 (14%)
Query: 824 VFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQE 883
+FG D++ + S + +P VV C+ ++ N + EGIFR+SG+ + +++
Sbjct: 504 LFGGDMEKFIQSSGQ------PVPLVVESCIRFINLN-GLQHEGIFRVSGAQLRVSEIRD 556
Query: 884 QFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIA 943
F++ D L E +H D+++VAG+LKLYFR L +F D++ E +
Sbjct: 557 AFERGEDP-LVEGCTAH----------DLDSVAGVLKLYFRSLEPPLFPPDLFGELLASS 605
Query: 944 ERNSGKPTETALQFRELVSNKRFEMENYSLMFV--LFELLMKINENNKVNKMNLRNLCIV 1001
E E + E VS + + L+ + LF L + + + N M+ NL +
Sbjct: 606 E------LEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVC 659
Query: 1002 FSPTLNIPV 1010
F PTL +PV
Sbjct: 660 FGPTL-LPV 667
>Hs20536040 [T] KOG4270 GTPase-activator protein
Length = 364
Score = 62.8 bits (151), Expect = 3e-09
Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 18/159 (11%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLK 905
IP VV+ +EYL ++ + +EG+FR++G+ +++ L+ +F+ V L K
Sbjct: 68 IPAVVWNIVEYLTQH-GLTQEGLFRVNGNVKVVEQLRLKFESGVPVELG----------K 116
Query: 906 NGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKR 965
+G DV + A LLKL+ R LP + + + R I G+ R+L+ K
Sbjct: 117 DG---DVCSAASLLKLFLRELPDSLITSAL--QPRFIQLFQDGRNDVQESSLRDLI--KE 169
Query: 966 FEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSP 1004
+Y L+ L + L K+ +++ N+MN+ NL VF P
Sbjct: 170 LPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGP 208
>Hs4502221 [T] KOG4271 Rho-GTPase activating protein
Length = 1499
Score = 61.6 bits (148), Expect = 6e-09
Identities = 51/191 (26%), Positives = 88/191 (45%), Gaps = 29/191 (15%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLK 905
IP V +C+E++ ++ + E ++R+SG+ + +Q+QF +++++NL +
Sbjct: 1271 IPLFVEKCVEFI-EDTGLCTERLYRVSGNKTDQENIQKQFVQDHNINLVSMEVT------ 1323
Query: 906 NGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKR 965
VN VAG LK +F LP + ++ E ++ TE +E+V K+
Sbjct: 1324 ------VNAVAGALKAFFADLPDPLIPYSLHPE--LLEAAKIPDKTERLHALKEIV--KK 1373
Query: 966 FEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIP----------VNILQP 1015
F NY + + L ++++ +K+N M NL I F L P I Q
Sbjct: 1374 FHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFGQPLMRPDLKSMEFLSTTKIHQS 1433
Query: 1016 FVEDF--QCIF 1024
VE F QC F
Sbjct: 1434 VVETFIQQCQF 1444
>Hs16163690 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 1022
Score = 61.2 bits (147), Expect = 8e-09
Identities = 53/187 (28%), Positives = 92/187 (48%), Gaps = 25/187 (13%)
Query: 836 SSRVYQNTHE--------IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDK 887
+SR +N+H IP +V C+ ++ + +GIFR+SGS + ++ F++
Sbjct: 438 TSRGRRNSHTRHQDSGQVIPLIVESCIRFI-NLYGLQHQGIFRVSGSQVEVNDIKNSFER 496
Query: 888 EYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNS 947
+ L + ++H D+N+VAG+LKLYFR L + +F + + + +I+
Sbjct: 497 GENP-LADDQSNH----------DINSVAGVLKLYFRGLENPLFPKERFND--LISCIRI 543
Query: 948 GKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLN 1007
E AL R+L+ +M LF L +++ + N M+ NL I F PTL
Sbjct: 544 DNLYERALHIRKLLLT--LPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTL- 600
Query: 1008 IPVNILQ 1014
+PV +Q
Sbjct: 601 MPVPEIQ 607
>Hs15147252 [T] KOG4270 GTPase-activator protein
Length = 621
Score = 60.8 bits (146), Expect = 1e-08
Identities = 53/177 (29%), Positives = 83/177 (45%), Gaps = 18/177 (10%)
Query: 833 LSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVN 892
+SL++ + + EI + C+ L + + EEG+FRL+ ++++K L++
Sbjct: 196 VSLATHLQELGREIALPIEACVMMLL-SEGMKEEGLFRLAAGASVLKRLKQTM------- 247
Query: 893 LCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTE 952
AS SL+ D + VAG LK Y R LP + D+Y++ A
Sbjct: 248 -----ASDPHSLEEF-CSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARL 301
Query: 953 TALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIP 1009
ALQ E+ S R EN S + L + L ++ E +VNKM N+ IV P L P
Sbjct: 302 QALQ--EVCS--RLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWP 354
>7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 1817
Score = 60.8 bits (146), Expect = 1e-08
Identities = 46/172 (26%), Positives = 83/172 (47%), Gaps = 14/172 (8%)
Query: 835 LSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLC 894
LS + + +IP V+ C E++ I +GI+RLSG ++ I+ L+ FD+E +L
Sbjct: 426 LSEHLLNSGQDIPMVLRSCAEFIENYGVI--DGIYRLSGITSNIQRLRRAFDEERVPDLG 483
Query: 895 EYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETA 954
D++ V+ LLK+YFR LP+ + +Y+ + + + E
Sbjct: 484 NPEMKQ----------DIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERL 533
Query: 955 LQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTL 1006
+E V + +Y + L E L K+++++ M +NL IV++P L
Sbjct: 534 RLMKETV--LKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNL 583
>YBR260c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 666
Score = 60.5 bits (145), Expect = 1e-08
Identities = 50/201 (24%), Positives = 91/201 (44%), Gaps = 34/201 (16%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKE-YDVNLCEYNASHEGSL 904
+P +V +C+ Y+ +++EGI+R S + + L+E+ DK+ ++++ + H S
Sbjct: 485 VPAIVRQCI-YVIDKFGLDQEGIYRKSANVLDVSKLKEEIDKDPANISMILPSKPHSDS- 542
Query: 905 KNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNK 964
D+ V LLK +F LP + + E +V + PT L+ N
Sbjct: 543 ------DIYLVGSLLKTFFASLPDSVLPKALSSEIKVCLQIED--PTTRKNFMHGLIYNL 594
Query: 965 RFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIPVNILQPFVEDFQCIF 1024
+ + ++L ++F L ++ + N+MNLR LCI++ PT+
Sbjct: 595 P-DAQYWTLRALVFHL-KRVLAHEAQNRMNLRALCIIWGPTI------------------ 634
Query: 1025 NGSDPVNNDDRQNINLQIPQM 1045
P N DD ++N QI M
Sbjct: 635 ---APANPDDANDVNFQIMAM 652
>SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 695
Score = 60.5 bits (145), Expect = 1e-08
Identities = 52/174 (29%), Positives = 84/174 (47%), Gaps = 18/174 (10%)
Query: 835 LSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLC 894
L + + + IP +V +C + +N +N +GI+R+ SSA + L+ QF+ + L
Sbjct: 508 LDAIILREHSNIPNIVMQCTSQV-ENFGLNLQGIYRVPSSSARVNMLRSQFENNPLLQL- 565
Query: 895 EYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETA 954
+E DV+ VA LLK++FR L + D+ + I N E
Sbjct: 566 HTPEDYEN--------DVHAVADLLKIFFRELREPLIPDNHQRD--FIDAGN----VEDE 611
Query: 955 LQFRELVSNKRFEME--NYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTL 1006
+ R+ V ++ NYS + L L KI EN+ VNKM+ NL I++ PT+
Sbjct: 612 SRRRDAVHRAINDLPDANYSTIRHLTIHLAKIKENSDVNKMSTNNLAIIWGPTI 665
>Hs4757766 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 439
Score = 60.5 bits (145), Expect = 1e-08
Identities = 54/223 (24%), Positives = 93/223 (41%), Gaps = 36/223 (16%)
Query: 820 ISNVVFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIK 879
+ N FG ++H + IP V+ + YL + A+ EGIFR S ++ +++
Sbjct: 237 LPNQQFGVSLQHLQEKNPE----QEPIPIVLRETVAYLQAH-ALTTEGIFRRSANTQVVR 291
Query: 880 TLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEEC 939
+Q++++ V+ +YN H A +LK + R LP + D+Y
Sbjct: 292 EVQQKYNMGLPVDFDQYNELH-------------LPAVILKTFLRELPEPLLTFDLYPHV 338
Query: 940 RVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLC 999
+ + LQ + + ENY ++ L L++I+ ++ NKM NL
Sbjct: 339 VGFLNIDESQRVPATLQVLQTLPE-----ENYQVLRFLTAFLVQISAHSDQNKMTNTNLA 393
Query: 1000 IVFSPTL------------NIPVNILQPFVEDFQC-IFNGSDP 1029
+VF P L P+N F+ D Q +F DP
Sbjct: 394 VVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDP 436
>CE21517 [T] KOG4270 GTPase-activator protein
Length = 604
Score = 59.3 bits (142), Expect = 3e-08
Identities = 54/189 (28%), Positives = 86/189 (44%), Gaps = 25/189 (13%)
Query: 819 AISNVVFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALI 878
A+ VFG + LS+ I V+ +C ++L +N +NE GIFR+SG+++ I
Sbjct: 233 ALPRPVFGVPLDEHLSIQKE------RISGVLTKCCDFLRQN-GMNERGIFRVSGNASKI 285
Query: 879 KTLQEQFDK-EYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYE 937
K ++ D ++D + YN D + VA LK Y R LP + D +
Sbjct: 286 KRIRAALDAGQFDADEKHYNN------------DPHAVASTLKAYLRELPDPLTMDSLQS 333
Query: 938 ECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRN 997
+ V A G+ +A+ R L R +N + L + L + + MN N
Sbjct: 334 DW-VEAINLEGEERFSAID-RCLKKMTRGHRQN---LIYLMKFLCDLEAKREETSMNASN 388
Query: 998 LCIVFSPTL 1006
L IVF+PT+
Sbjct: 389 LAIVFAPTM 397
>YDR379w_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 868
Score = 59.3 bits (142), Expect = 3e-08
Identities = 49/197 (24%), Positives = 90/197 (44%), Gaps = 34/197 (17%)
Query: 834 SLSSRVYQNTHEIPTVVYRCLEYLYKNR-AINEEGIFRLSGSSALIKTLQEQFDKEYDVN 892
SL +R +P ++ C++ + K+ +N EG++R SGS L++ ++ +F
Sbjct: 648 SLQARCAYEKSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEF------- 700
Query: 893 LCEYNASHEGSLKNGPYL------DVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERN 946
+ N+ H +L P L D++ VA +LK Y R+LP + +Y+ + N
Sbjct: 701 -AQNNSLHSDTLS--PKLNALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNN 757
Query: 947 S----------------GKPTETALQFRELVSN-KRFEMENYSLMFVLFELLMKINENNK 989
K T + + L+ K +E+ ++ VL + K+ ++
Sbjct: 758 QLIERLPLNNDKFLDSPQKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSE 817
Query: 990 VNKMNLRNLCIVFSPTL 1006
N MNL NL +VF+P+L
Sbjct: 818 RNLMNLHNLSLVFAPSL 834
>YER155c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 2167
Score = 58.9 bits (141), Expect = 4e-08
Identities = 55/220 (25%), Positives = 102/220 (46%), Gaps = 22/220 (10%)
Query: 787 STSSLDITKESDETSAERSFASALHGMNLHDEAISNVVFGSDIKHCLSLSSRVYQNTHEI 846
+ SS D+T+ A + F+ H + N +FG ++ + + I
Sbjct: 1930 TASSSDLTEWIKMIKASKRFS--FHSKKYKGKT-HNKIFGVPLEDVCERENTL------I 1980
Query: 847 PTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLKN 906
PT+V + LE + + R ++E G++R+ GS I L+ FD+E + + +L++
Sbjct: 1981 PTIVVKLLEEI-ELRGLDEVGLYRIPGSIGSINALKNAFDEEGATD-------NSFTLED 2032
Query: 907 GPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIA---ERNSGKPTETALQFRELVSN 963
+ +VN +AG K+Y R LP +F M + +A + ++ E EL+
Sbjct: 2033 DRWFEVNAIAGCFKMYLRELPDSLFSHAMVNDFTDLAIKYKAHAMVNEEYKRMMNELL-- 2090
Query: 964 KRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFS 1003
++ Y + + L K++++ NKM+ NL IVFS
Sbjct: 2091 QKLPTCYYQTLKRIVFHLNKVHQHVVNNKMDASNLAIVFS 2130
>CE00918 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 837
Score = 58.9 bits (141), Expect = 4e-08
Identities = 61/229 (26%), Positives = 108/229 (46%), Gaps = 34/229 (14%)
Query: 786 LSTS-SLDITKESDETSAE---RSFASALHGMNLHDEAI--SNVVFGSDIKHCLSLSSRV 839
+STS S D + S ET E R F + +L ++ I VFGS + S +
Sbjct: 563 VSTSVSTDEPRPSKETIIEKLRRFFRTRPTVESLKEKGIYKPEPVFGSTL-------SAI 615
Query: 840 YQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNA- 898
Q+ + + R + + +++ + +GI+R+SG+ + ++ ++ Q D++ Y A
Sbjct: 616 CQHENSLVPKFIRVITEVIESKGLETDGIYRVSGNLSAVQKIRCQADQD------NYKAL 669
Query: 899 -SHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQF 957
S E D++ + G LKL+FR L +F +++E + + T +F
Sbjct: 670 VSEE---------DIHVLTGALKLFFRELTDPLFPISLHKEYTSAMQMPNA--TTRFKKF 718
Query: 958 RELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTL 1006
EL+S R EN + +L L ++ ++ N+M NL IVF PTL
Sbjct: 719 EELLS--RLPNENRETLKMLLRHLNRVASHSSQNRMQQHNLAIVFGPTL 765
>Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 710
Score = 58.2 bits (139), Expect = 7e-08
Identities = 48/189 (25%), Positives = 84/189 (44%), Gaps = 17/189 (8%)
Query: 818 EAISNVVFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSAL 877
+A +FG + L +V +T ++P V+ L L K R ++ EGI R+ GS A
Sbjct: 233 KAAETRLFGVPLDSLLEADHKVLPST-QVPLVLQALLSCLEK-RGLDMEGILRVPGSQAR 290
Query: 878 IKTLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYE 937
+K L+++ ++++ L ++ H N + LLK + R+LP + +
Sbjct: 291 VKGLEQKLERDFYAGLFSWDEVHH-----------NDASDLLKRFIRKLPTPLLTAEYLP 339
Query: 938 ECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRN 997
V+ + K L L+ + N + + L E L K+ + NKM LRN
Sbjct: 340 AFAVVPNIPNLKQRLQVLHLLILILPE----PNRNALKALLEFLRKVVAREQHNKMTLRN 395
Query: 998 LCIVFSPTL 1006
+ V +P L
Sbjct: 396 VSTVMAPNL 404
>7295587 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 2110
Score = 57.8 bits (138), Expect = 9e-08
Identities = 49/178 (27%), Positives = 83/178 (46%), Gaps = 17/178 (9%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFD-KEYDVNLCEYNASHEGSL 904
+P +V C + + + + GI+R+ G+ A I L E + K++ C + E
Sbjct: 1213 VPHLVEVCTN-IVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWE--- 1268
Query: 905 KNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNK 964
DVN V+ LLKL+ R LP + Y + A++ G E + RE+V +
Sbjct: 1269 ------DVNVVSSLLKLFIRSLPDALMPASYYINF-IEADKKFG--LERIVLLREIVES- 1318
Query: 965 RFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPT-LNIPVNILQPFVEDFQ 1021
Y M L L +++ N VN+M +NL I+F P+ + P + L+ V+D +
Sbjct: 1319 -LPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMK 1375
>Hs7661858 [TZ] KOG2710 Rho GTPase-activating protein
Length = 1023
Score = 57.4 bits (137), Expect = 1e-07
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 20/144 (13%)
Query: 863 INEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLY 922
I+ EG+FR SGS +K L+ + D EG L + P D+ AGLLK +
Sbjct: 80 IHTEGLFRKSGSVIRLKALKNKVDHG------------EGCLSSAPPCDI---AGLLKQF 124
Query: 923 FRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLM 982
FR LP I D++E + + + + L L+++ + Y F L
Sbjct: 125 FRELPEPILPADLHEALLKAQQLGTEEKNKATLLLSCLLADHTVHVLRY-----FFNFLR 179
Query: 983 KINENNKVNKMNLRNLCIVFSPTL 1006
++ + NKM+ NL ++F+P L
Sbjct: 180 NVSLRSSENKMDSSNLAVIFAPNL 203
>Hs21361736 [T] KOG4270 GTPase-activator protein
Length = 803
Score = 56.2 bits (134), Expect = 3e-07
Identities = 52/190 (27%), Positives = 82/190 (42%), Gaps = 24/190 (12%)
Query: 817 DEAISNVVFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSA 876
D+ FG+ ++ L S R EI + C+ L + + EEG+FR+ ++
Sbjct: 242 DKWAEKPAFGTPLEEHLKRSGR------EIALPIEACVMLLLET-GMKEEGLFRIGAGAS 294
Query: 877 LIKTLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMY 936
+K L+ D + SH Y D + VAG LK Y R LP + ++Y
Sbjct: 295 KLKKLKAALD---------CSTSHLDEF----YSDPHAVAGALKSYLRELPEPLMTFNLY 341
Query: 937 EECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLR 996
EE +A S + + LQ K +N+ L + L K+ + + VNKM
Sbjct: 342 EEWTQVA---SVQDQDKKLQDLWRTCQK-LPPQNFVNFRYLIKFLAKLAQTSDVNKMTPS 397
Query: 997 NLCIVFSPTL 1006
N+ IV +P L
Sbjct: 398 NIAIVLAPNL 407
>Hs7662242 [T] KOG4270 GTPase-activator protein
Length = 818
Score = 55.8 bits (133), Expect = 3e-07
Identities = 57/224 (25%), Positives = 97/224 (42%), Gaps = 41/224 (18%)
Query: 825 FGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQ 884
FG ++ L++S R EI + C+ L + + EEG+FR++ S++ +K L+
Sbjct: 253 FGKPLEEHLTISGR------EIAFPIEACVTMLLEC-GMQEEGLFRVAPSASKLKKLKAA 305
Query: 885 FDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAE 944
D V++ EY+A D + +AG LK Y R LP + ++Y+E +
Sbjct: 306 LDCCV-VDVQEYSA------------DPHAIAGALKSYLRELPEPLMTFELYDEW---IQ 349
Query: 945 RNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSP 1004
++ + + LQ K N++ + L + L K++E VNKM N+ IV P
Sbjct: 350 ASNVQEQDKKLQALWNACEK-LPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGP 408
Query: 1005 TLNIP-----------------VNILQPFVEDFQCIFNGSDPVN 1031
L P V I++P ++ F G N
Sbjct: 409 NLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFN 452
>Hs22045949 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 1444
Score = 55.8 bits (133), Expect = 3e-07
Identities = 50/182 (27%), Positives = 87/182 (47%), Gaps = 22/182 (12%)
Query: 825 FGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQ 884
FG D+ L S + ++P V+ C E++ + + +GI+RLSG ++ I+ L+++
Sbjct: 19 FGCDLTEYLESSGQ------DVPYVLKSCAEFIETHGIV--DGIYRLSGVTSNIQRLRQE 70
Query: 885 FDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAE 944
F + +L + E L+ D++ V L KLYFR LP+ + ++YE+ E
Sbjct: 71 FGSDQCPDL-----TREVYLQ-----DIHCVGSLCKLYFRELPNPLLTYELYEK---FTE 117
Query: 945 RNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSP 1004
S P E L + V + +Y + L L I + M+ RNL +V++P
Sbjct: 118 AVSHCPEEGQLARIQNVI-QELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
Query: 1005 TL 1006
L
Sbjct: 177 NL 178
>CE26357 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 1388
Score = 55.8 bits (133), Expect = 3e-07
Identities = 43/165 (26%), Positives = 80/165 (48%), Gaps = 11/165 (6%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLK 905
+P +V C+ + + ++ GI+R+ G++A + L+E + S SL
Sbjct: 745 VPMIVQACV-CVIETYGMDTVGIYRIPGNTAAVNALKESLSNR---GFDSVDLSKVESL- 799
Query: 906 NGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETAL-QFRELVSNK 964
+ + DVN V+ LLK++ R+LP + D +Y + N L + R L+ +
Sbjct: 800 DPRWRDVNVVSSLLKMFLRKLPEPLLTDKLYP---FFIDANRISTHHNRLHKLRNLL--R 854
Query: 965 RFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLNIP 1009
+ +Y + L L +I +++ VNKM RNL ++F P++ P
Sbjct: 855 KLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRP 899
>CE16059 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 718
Score = 55.5 bits (132), Expect = 4e-07
Identities = 46/182 (25%), Positives = 80/182 (43%), Gaps = 26/182 (14%)
Query: 833 LSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVN 892
L L+ + ++P +V +C + + GI+R G + I+ L+ +FD + +
Sbjct: 239 LELTDLYMRTGKKVPVIVEKCCASIEDQGIVT--GIYRQCGIQSNIQRLRAKFDSGAEPD 296
Query: 893 LCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTE 952
L E+ D+ +V+ LLK YFR+LP+ +F Y + E+
Sbjct: 297 LHEFGQR-----------DIYSVSSLLKQYFRQLPNPLFTYQAYPKLIEAFEKED----- 340
Query: 953 TALQFRELVSNKRFEME-----NYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLN 1007
E V + RF +E +Y L E L ++ ++ + M +NL IV+SP L
Sbjct: 341 ---SLSEKVESLRFSLETMPEAHYRTAKFLMEHLTRLCKSKSLTDMTSKNLAIVWSPNLF 397
Query: 1008 IP 1009
P
Sbjct: 398 RP 399
>HsM19923515 [T] KOG4270 GTPase-activator protein
Length = 726
Score = 55.1 bits (131), Expect = 6e-07
Identities = 52/190 (27%), Positives = 80/190 (41%), Gaps = 24/190 (12%)
Query: 817 DEAISNVVFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSA 876
D+ FG+ + L S R EI + C+ L + + EEG+FR+ ++
Sbjct: 165 DKWAEKPAFGTPLAEHLKRSGR------EIALPIEACVMLLLET-GMKEEGLFRIGAGAS 217
Query: 877 LIKTLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMY 936
+K L+ D + SH Y D + VAG LK Y R LP + ++Y
Sbjct: 218 KLKKLKAALD---------CSTSHLDEF----YSDPHAVAGALKSYLRELPEPLMTFNLY 264
Query: 937 EECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLR 996
EE +A S + + LQ K +N+ L + L K+ + + VNKM
Sbjct: 265 EEWTQVA---SVQDQDKKLQDLWRTCQK-LPPQNFVNFRYLIKFLAKLAQTSDVNKMTPS 320
Query: 997 NLCIVFSPTL 1006
N+ IV P L
Sbjct: 321 NIAIVLGPNL 330
>Hs14210510 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 750
Score = 55.1 bits (131), Expect = 6e-07
Identities = 47/182 (25%), Positives = 85/182 (45%), Gaps = 12/182 (6%)
Query: 835 LSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVN-- 892
L S + +P+ + C+ + K R ++ +GI+R+SG+ A+++ L+ D+E V
Sbjct: 544 LESLCQREGDTVPSFLRLCIAAVDK-RGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSD 602
Query: 893 ---LCEYNASHEG--SLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNS 947
+ EG L + + D++ V G LKL+ R LP + + R +
Sbjct: 603 GRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSE 662
Query: 948 GKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLN 1007
+ + Q +EL+ + N+ + L E L ++ ++ N+M NL IVF PTL
Sbjct: 663 SE--QCLSQIQELIGS--MPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLF 718
Query: 1008 IP 1009
P
Sbjct: 719 RP 720
>At1g08340 [T] KOG4270 GTPase-activator protein
Length = 331
Score = 54.3 bits (129), Expect = 1e-06
Identities = 41/162 (25%), Positives = 79/162 (48%), Gaps = 27/162 (16%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLK 905
+P ++ LY + EG+FR++G ++ + ++EQ +K G +
Sbjct: 64 VPVILLLLQSRLYDQGGLQAEGVFRITGENSEEEFVREQLNK--------------GIIP 109
Query: 906 NGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKR 965
+G +DV+ +AGL+K +FR LP + D + E + E + E ++ L+
Sbjct: 110 DG--IDVHCLAGLIKAWFRELPRGVL-DPLPSEQVMQCESD-----EDFVKVVRLLPQTE 161
Query: 966 FEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTLN 1007
+ N+++ L+ + + VNKMN RNL +VF+P ++
Sbjct: 162 ASLLNWAI-----NLMADVIQFEHVNKMNSRNLALVFAPNMS 198
>7302107 [T] KOG1452 Predicted Rho GTPase-activating protein
Length = 1844
Score = 53.9 bits (128), Expect = 1e-06
Identities = 46/193 (23%), Positives = 87/193 (44%), Gaps = 14/193 (7%)
Query: 824 VFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQE 883
+FG+D++ ++ S+ + +P V+ RC+E + + R ++ G++RL GS+ + L+E
Sbjct: 920 LFGADLETVVNRESKNAPGSAPVPIVLRRCVEEV-ERRGLDIIGLYRLCGSATKKRLLRE 978
Query: 884 QFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYE-ECRVI 942
F++ S L D+N + G+LK Y R LP +F +++ +
Sbjct: 979 AFERN----------SRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTVDAL 1028
Query: 943 AERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVF 1002
A P A ++ N + + L + L + N++ NKM+ + L V
Sbjct: 1029 AVCLPDDPEGNAKLMLSILD--CLPRANRATLVFLLDHLSLVVSNSERNKMSAQALATVM 1086
Query: 1003 SPTLNIPVNILQP 1015
P L + QP
Sbjct: 1087 GPPLMLHSASAQP 1099
>Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 618
Score = 52.8 bits (125), Expect = 3e-06
Identities = 39/179 (21%), Positives = 83/179 (45%), Gaps = 19/179 (10%)
Query: 832 CLSLSSRVYQNTHEIP----TVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDK 887
C+ L++ + Q+ ++P ++++ L + R + EG+ R+ G++ IK L ++ +
Sbjct: 278 CVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEA 337
Query: 888 EYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNS 947
++ +EG+ N + + A LLKL+ R LP + + + + + +
Sbjct: 338 KF----------YEGTF-NWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPT 386
Query: 948 GKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTL 1006
K AL ++ N + L E L ++ +N + NKM + N+ +V +P L
Sbjct: 387 KKQQLQALNLLVIL----LPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNL 441
>At4g03100 [T] KOG4270 GTPase-activator protein
Length = 424
Score = 52.8 bits (125), Expect = 3e-06
Identities = 41/163 (25%), Positives = 78/163 (47%), Gaps = 27/163 (16%)
Query: 844 HEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGS 903
+ +PT++ E LY + + EGIFR++ ++ + +++Q ++ G
Sbjct: 133 NSVPTILLLMQERLYSQQGLKAEGIFRINPENSQEEHVRDQLNR--------------GI 178
Query: 904 LKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSN 963
+ +DV+ +AGL+K +FR LP + EE N E+ EL+
Sbjct: 179 VPEN--IDVHCLAGLIKAWFRELPSGVLDGLSPEEVL-----NCNTEDESV----ELI-- 225
Query: 964 KRFEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTL 1006
K+ + +L+ +L+ + E + NKMN RN+ +VF+P +
Sbjct: 226 KQLKPTESALLNWAVDLMADVVEEEESNKMNARNIAMVFAPNM 268
>At3g11490 [T] KOG4270 GTPase-activator protein
Length = 435
Score = 52.8 bits (125), Expect = 3e-06
Identities = 41/161 (25%), Positives = 76/161 (46%), Gaps = 27/161 (16%)
Query: 846 IPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLK 905
+PT++ +LY + EGIFR++G + + ++E+ +K G +
Sbjct: 154 VPTILLMMQSHLYSRGGLRVEGIFRINGENGQEEYIREELNK--------------GIIP 199
Query: 906 NGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYEECRVIAERNSGKPTETALQFRELVSNKR 965
+ +DV+ +A L+K +FR LP + D +V+ + + E R L S +
Sbjct: 200 DN--IDVHCLASLIKAWFRELPSGVL--DSLSPEQVMESESEDECVELV---RLLPSTEA 252
Query: 966 FEMENYSLMFVLFELLMKINENNKVNKMNLRNLCIVFSPTL 1006
SL+ L+ + E ++NKMN RN+ +VF+P +
Sbjct: 253 ------SLLDWAINLMADVVEMEQLNKMNARNIAMVFAPNM 287
>YOR134w [TZ] KOG2710 Rho GTPase-activating protein
Length = 409
Score = 52.4 bits (124), Expect = 4e-06
Identities = 54/201 (26%), Positives = 91/201 (44%), Gaps = 20/201 (9%)
Query: 814 NLHDEAISNVVFGSDIKHCLSLSSR---VYQNTHEI---PTVVYRCLEYLYKNRAINEEG 867
NL +E VFG ++ L ++ + ++T+EI P V+ + +YL +N A++ G
Sbjct: 38 NLQNE-FDGKVFGVSLEESLKVAQEEVIIQKSTNEIGSIPVVIAKSGKYLKEN-ALDTTG 95
Query: 868 IFRLSGSSALIKTLQEQFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLP 927
IFR++GS+ ++ LQ F K D Y EG +V+ +A LLK Y L
Sbjct: 96 IFRIAGSNKRVRELQAVFSKPPD-----YGRKFEGWCD----FNVHDIATLLKRYLNSLS 146
Query: 928 HLIFGDDMYEECR--VIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKIN 985
+ +Y+ R ++ + E ++ E + +N L+ L LL
Sbjct: 147 EPLVPLALYDIFRNPILENPKINEHKEQIIKDYEDI-YMLLPQQNRHLILYLAALLNLFA 205
Query: 986 ENNKVNKMNLRNLCIVFSPTL 1006
N K N M+ NL + P+L
Sbjct: 206 RNEKKNLMSASNLAAIVQPSL 226
>CE06642 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 634
Score = 52.4 bits (124), Expect = 4e-06
Identities = 46/190 (24%), Positives = 89/190 (46%), Gaps = 27/190 (14%)
Query: 824 VFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQE 883
+FG +K L +QN H IP ++ + ++ L + R + +GI+R G + I+ +
Sbjct: 176 IFGVPLKGLLE-----HQNRH-IPLIIEKSIDQLQR-RGLRAKGIYRTCGVKSKIEEICN 228
Query: 884 QFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYE------ 937
F++ ++ E L N +++ A ++KLY R+LP + ++Y+
Sbjct: 229 AFERS--------SSDDEVCLDNENPMNL---ASVVKLYLRKLPEPLLTFELYDDFVRLG 277
Query: 938 -ECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLR 996
EC S E Q R+L ++ + NY + + L +++ ++VN M+
Sbjct: 278 TECCSAQASGSNCEEERVEQLRQLA--RKLPVHNYETLKFIMLHLNRVSWFHEVNLMSTS 335
Query: 997 NLCIVFSPTL 1006
NL V +P+L
Sbjct: 336 NLSTVIAPSL 345
>CE06641 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 863
Score = 52.4 bits (124), Expect = 4e-06
Identities = 46/190 (24%), Positives = 89/190 (46%), Gaps = 27/190 (14%)
Query: 824 VFGSDIKHCLSLSSRVYQNTHEIPTVVYRCLEYLYKNRAINEEGIFRLSGSSALIKTLQE 883
+FG +K L +QN H IP ++ + ++ L + R + +GI+R G + I+ +
Sbjct: 405 IFGVPLKGLLE-----HQNRH-IPLIIEKSIDQLQR-RGLRAKGIYRTCGVKSKIEEICN 457
Query: 884 QFDKEYDVNLCEYNASHEGSLKNGPYLDVNTVAGLLKLYFRRLPHLIFGDDMYE------ 937
F++ ++ E L N +++ A ++KLY R+LP + ++Y+
Sbjct: 458 AFERS--------SSDDEVCLDNENPMNL---ASVVKLYLRKLPEPLLTFELYDDFVRLG 506
Query: 938 -ECRVIAERNSGKPTETALQFRELVSNKRFEMENYSLMFVLFELLMKINENNKVNKMNLR 996
EC S E Q R+L ++ + NY + + L +++ ++VN M+
Sbjct: 507 TECCSAQASGSNCEEERVEQLRQLA--RKLPVHNYETLKFIMLHLNRVSWFHEVNLMSTS 564
Query: 997 NLCIVFSPTL 1006
NL V +P+L
Sbjct: 565 NLSTVIAPSL 574
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.314 0.131 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,869,450
Number of Sequences: 60738
Number of extensions: 2513040
Number of successful extensions: 6127
Number of sequences better than 1.0e-05: 54
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 6004
Number of HSP's gapped (non-prelim): 69
length of query: 1045
length of database: 30,389,216
effective HSP length: 117
effective length of query: 928
effective length of database: 23,282,870
effective search space: 21606503360
effective search space used: 21606503360
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)