ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0240 good B KOG1343 Chromatin structure and dynamics Histone deacetylase complex, catalytic component HDA1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0240 80666 78522 -715
(715 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL116w [B] KOG1343 Histone deacetylase complex catalytic compon... 793 0.0
CE25887 [B] KOG1343 Histone deacetylase complex catalytic compon... 88 5e-17
CE20772 [B] KOG1343 Histone deacetylase complex catalytic compon... 88 5e-17
Hs17158039 [B] KOG1343 Histone deacetylase complex catalytic com... 77 1e-13
At4g33470 [B] KOG1343 Histone deacetylase complex catalytic comp... 76 2e-13
7293057 [B] KOG1343 Histone deacetylase complex catalytic compon... 75 3e-13
Hs5174481 [B] KOG1343 Histone deacetylase complex catalytic comp... 73 1e-12
Hs4885531 [B] KOG1343 Histone deacetylase complex catalytic comp... 70 1e-11
Hs21237799 [B] KOG1343 Histone deacetylase complex catalytic com... 70 1e-11
7292853 [B] KOG1343 Histone deacetylase complex catalytic compon... 70 1e-11
Hs13259524 [B] KOG1343 Histone deacetylase complex catalytic com... 69 3e-11
Hs13259522 [B] KOG1343 Histone deacetylase complex catalytic com... 69 3e-11
CE20787 [B] KOG1343 Histone deacetylase complex catalytic compon... 68 4e-11
CE08062 [B] KOG1343 Histone deacetylase complex catalytic compon... 66 2e-10
Hs17158041 [B] KOG1343 Histone deacetylase complex catalytic com... 64 8e-10
At5g61060 [B] KOG1343 Histone deacetylase complex catalytic comp... 64 8e-10
Hs13128864 [B] KOG1343 Histone deacetylase complex catalytic com... 63 2e-09
YNL021w [B] KOG1343 Histone deacetylase complex catalytic compon... 62 2e-09
SPBC800.03 [B] KOG1343 Histone deacetylase complex catalytic com... 62 4e-09
Hs20070354 [B] KOG1343 Histone deacetylase complex catalytic com... 60 9e-09
At1g08460 [B] KOG1343 Histone deacetylase complex catalytic comp... 60 1e-08
At3g18520 [B] KOG1343 Histone deacetylase complex catalytic comp... 58 4e-08
CE24411 [B] KOG1343 Histone deacetylase complex catalytic compon... 53 2e-06
>YPL116w [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 697
Score = 793 bits (2047), Expect = 0.0
Identities = 408/718 (56%), Positives = 488/718 (67%), Gaps = 67/718 (9%)
Query: 4 DPLHNFKVQFEKFVASNPNVSSVTSSASRIPESSKAVIVLSPYSLSHQFPRYWVSKSYKK 63
DPL F QF+ FV +NPNV S +A++IPES+KAV+VLSPYSL H FPR WV+KSY+K
Sbjct: 7 DPLERFYKQFQAFVQNNPNVISAARAAAQIPESAKAVVVLSPYSLQHVFPREWVTKSYRK 66
Query: 64 TIVERPERLLACCIGVSAAITMYPALFSVKTSNHHKTSLLAPHVLKVHGKDWPRXXXXXX 123
TIVERPERLLA +G+SAAITMYP+LF++K+S+ K SL+APHVLKVHG WP
Sbjct: 67 TIVERPERLLASSMGISAAITMYPSLFTLKSSHQRKGSLMAPHVLKVHGSSWPAELIELC 126
Query: 124 XXXXXXIDNEEVEVPPDWNVGDIYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRA 183
+ E+EVP WN GDIYLS TI AL+G+IGA+E GVDSIF+G S E +NRA
Sbjct: 127 QMADAKLLKGEIEVPDTWNSGDIYLSSKTIKALQGTIGAIETGVDSIFKGPSAEHISNRA 186
Query: 184 FIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWK 243
F+AIRPPGHH H TPSGFCLLNNAH+AIEYA++ Y+VTH V+LDFDLHHGDGTQDICWK
Sbjct: 187 FVAIRPPGHHCHYGTPSGFCLLNNAHVAIEYAYDTYNVTHVVVLDFDLHHGDGTQDICWK 246
Query: 244 RAGFRPDEFSTDAEHGASEDDNKYDEFGKSFAEFPKVGYFSLHDINSFPTELGYATKENI 303
RAGF+P+E +D+ YD+FGK FAEFPKVGYFS+HDINSFPTE G+ATKENI
Sbjct: 247 RAGFKPEE---------EPEDSSYDDFGKKFAEFPKVGYFSMHDINSFPTESGFATKENI 297
Query: 304 RNASTCIMDAHDINIWNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMKQGGF 363
+NASTCIM++HD+NIWN+HL + EEEF LY+TKYR++FAKADEFF++AKLEM Q G
Sbjct: 298 KNASTCIMNSHDLNIWNIHLSKWTTEEEFNVLYRTKYRTLFAKADEFFRSAKLEMNQQGR 357
Query: 364 RFKGLVVISAGFDASEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISVMEGG 423
FKGLVVISAGFDASE+EQ SMQRH+VNVPTSFY FTKDALKLAQMH +GK++S+MEGG
Sbjct: 358 PFKGLVVISAGFDASEFEQTSMQRHSVNVPTSFYTTFTKDALKLAQMHCHGKVLSLMEGG 417
Query: 424 YSDGAIASGVFSHLIGFQNQNWISEWGSEQVVKEIIRGCKPRWKPYKTKKARDVIRIWAE 483
YSD AI SGVF+HLIG QNQ+W+ EWGSEQVVKEI+RGCKP WKPYKTK+A+DVIRIWAE
Sbjct: 418 YSDKAICSGVFAHLIGLQNQDWVKEWGSEQVVKEIVRGCKPAWKPYKTKRAKDVIRIWAE 477
Query: 484 EVIMLGRSMIPEFEKVLFD-------------------TEDTVTHPEVRLTRSKYHETIV 524
EVI LGR+MIPEF+ ++F + T+ +R RS
Sbjct: 478 EVIRLGRAMIPEFDDIIFKDAVNSAPSNSLLKATVEPASTSTIAQRIIRSHRSNASPEKE 537
Query: 525 KHENEIPRTE--------TPTPVRREKPSEQPKDENVPFVDQILPSXXXXXXXXXXXXXX 576
HEN+ TE + T V++ + + + +PF+ Q S
Sbjct: 538 LHENKPRSTEKQEQREIRSDTKVKQLSSNNRAAETQIPFLQQEFSS---EDEDEEYVYDE 594
Query: 577 XLNKTFNRTVEDITIDDISRHLETLDIIQAKXXXXXXXXXHHGDNGQSHRARTRVPVNSH 636
LNKTFNRTVEDITIDDISRHLETL+I GD H + + NSH
Sbjct: 595 ELNKTFNRTVEDITIDDISRHLETLEI------------EKKGDEDSDHELKEKNWKNSH 642
Query: 637 XXXXXXXXXXXXXXXXXXXXXXVGGYKIPXXXXXXXXXXXXXXXXXXFDDSDISMISH 694
G YKIP +DDSDISMISH
Sbjct: 643 QRRLQGN----------------GMYKIPSNTKPHRIRQPQNANTPTYDDSDISMISH 684
>CE25887 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 955
Score = 87.8 bits (216), Expect = 5e-17
Identities = 41/112 (36%), Positives = 69/112 (61%), Gaps = 3/112 (2%)
Query: 132 NEEVEVPPDWNVGDIYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRAFIAIRPPG 191
+EE+ + IYL++ T+ ++GA+ VD IF+ + ++ A + +RPPG
Sbjct: 503 DEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNA---LVIVRPPG 559
Query: 192 HHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWK 243
HH+ AS SGFC+ NN +A +YA ++ +ILD+D+HHG+GTQ+I ++
Sbjct: 560 HHASASKSSGFCIFNNVAVAAKYAQRRHKAKRVLILDWDVHHGNGTQEIFYE 611
Score = 61.6 bits (148), Expect = 4e-09
Identities = 29/61 (47%), Positives = 37/61 (60%), Gaps = 1/61 (1%)
Query: 180 ANRAFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQD 239
A+ F +RPPGHH+ + +P GFCL NN A E AF +I+D D+HHG GTQ
Sbjct: 133 ASNGFAVVRPPGHHADSVSPCGFCLFNNVAQAAEEAFFS-GAERILIVDLDVHHGHGTQR 191
Query: 240 I 240
I
Sbjct: 192 I 192
>CE20772 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 863
Score = 87.8 bits (216), Expect = 5e-17
Identities = 41/112 (36%), Positives = 69/112 (61%), Gaps = 3/112 (2%)
Query: 132 NEEVEVPPDWNVGDIYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRAFIAIRPPG 191
+EE+ + IYL++ T+ ++GA+ VD IF+ + ++ A + +RPPG
Sbjct: 503 DEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNA---LVIVRPPG 559
Query: 192 HHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWK 243
HH+ AS SGFC+ NN +A +YA ++ +ILD+D+HHG+GTQ+I ++
Sbjct: 560 HHASASKSSGFCIFNNVAVAAKYAQRRHKAKRVLILDWDVHHGNGTQEIFYE 611
Score = 61.6 bits (148), Expect = 4e-09
Identities = 29/61 (47%), Positives = 37/61 (60%), Gaps = 1/61 (1%)
Query: 180 ANRAFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQD 239
A+ F +RPPGHH+ + +P GFCL NN A E AF +I+D D+HHG GTQ
Sbjct: 133 ASNGFAVVRPPGHHADSVSPCGFCLFNNVAQAAEEAFFS-GAERILIVDLDVHHGHGTQR 191
Query: 240 I 240
I
Sbjct: 192 I 192
>Hs17158039 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1011
Score = 76.6 bits (187), Expect = 1e-13
Identities = 67/277 (24%), Positives = 115/277 (41%), Gaps = 68/277 (24%)
Query: 159 SIGALEIGVDSIFQGVSVEQTAN--RAFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAF 216
S GA + V + + S + F +RPPGHH+ ST GFC N+ I +Y
Sbjct: 747 SSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLR 806
Query: 217 EKYDVTHAVILDFDLHHGDGTQDICWKRAGFRPDEFSTDAEHGASEDDNKYDEFGKSFAE 276
++ +++ +I+D D+HHG+GTQ ++F
Sbjct: 807 DQLNISKILIVDLDVHHGNGTQ---------------------------------QAFYA 833
Query: 277 FPKVGYFSLH---DINSFPTELGYATKENIRNASTCIMDAHDINI-WNVHLQSYKDEEEF 332
P + Y SLH + N FP G + T + + ++INI W L + E+
Sbjct: 834 DPSILYISLHRYDEGNFFP---GSGAPNEV---GTGLGEGYNINIAWTGGLDPPMGDVEY 887
Query: 333 VKLYQTKYRSIFAKADEFFKNAKLEMKQGGFRFKGLVVISAGFDASEYEQQSMQRHNVNV 392
++ ++T + + + D +V++SAGFDA E + + V
Sbjct: 888 LEAFRTIVKPVAKEFD-----------------PDMVLVSAGFDALEGHTPPLGGYKVT- 929
Query: 393 PTSFYNLFTKDALKLAQMHSNGKIISVMEGGYSDGAI 429
+ TK + LA +G+++ +EGG+ AI
Sbjct: 930 -AKCFGHLTKQLMTLA----DGRVVLALEGGHDLTAI 961
>At4g33470 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 359
Score = 75.9 bits (185), Expect = 2e-13
Identities = 72/298 (24%), Positives = 115/298 (38%), Gaps = 78/298 (26%)
Query: 152 TIAALEGSIGALEIGVDSIFQGVSVEQTANR--AFIAIRPPGHHSHASTPSGFCLLNNAH 209
T+ AL S GA VDS+ + + F IRPPGHH+ P GFC+ N
Sbjct: 95 TVTALCSSAGAGMALVDSVVMSRLTINSVDPPIGFALIRPPGHHAVPKGPMGFCVFGNVA 154
Query: 210 IAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWKRAGFRPDEFSTDAEHGASEDDNKYDE 269
IA +A + + I+DFD+HHG+GT D
Sbjct: 155 IAARHAQRTHGLKRIFIIDFDVHHGNGTND------------------------------ 184
Query: 270 FGKSFAEFPKVGYFSLHDINSFP-----TELGYATKENIRNASTCIMDAHDINIWNVHLQ 324
+F E P + + S H S+P +++G E + DI +
Sbjct: 185 ---AFTEDPDIFFLSTHQDGSYPGTGKISDIGKGKGEGTTLNLPLPGGSGDIAM------ 235
Query: 325 SYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMKQGGFRFKGLVVISAGFDASEYEQQS 384
+T + I + FK ++++SAG+DA + +
Sbjct: 236 ------------RTVFEEIIVPCAQRFK-------------PDIILVSAGYDAHVLDPLA 270
Query: 385 MQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISVMEGGYSDGAIASGV---FSHLIG 439
N+ T+ Y KD +LA+ G+ + +EGGY+ +++S V F L+G
Sbjct: 271 ----NLQFTTATYYSLAKDIKRLAKEVCGGRCVFFLEGGYNLESLSSSVADSFRALLG 324
>7293057 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 883
Score = 75.5 bits (184), Expect = 3e-13
Identities = 78/289 (26%), Positives = 113/289 (38%), Gaps = 74/289 (25%)
Query: 146 IYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRAFIAIRPPGHHSHASTPSGFCLL 205
+YL T + G + VDS+ +G S N +RPPGHH+ P GFC+
Sbjct: 547 VYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICN-----VRPPGHHAEQDHPHGFCIF 601
Query: 206 NNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWKRAGFRPDEFSTDAEHGASEDDN 265
NN IA +YA + + +I+D+D+HHG+GTQ I
Sbjct: 602 NNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHI------------------------- 636
Query: 266 KYDEFGKSFAEFPKVGYFSLHDI---NSFPTELGYATKENIRNASTCIMDAHDINI-WNV 321
F PKV Y SLH + FP N ++NI WN
Sbjct: 637 --------FESNPKVLYISLHRYEHGSFFPK----GPDGNFDVVGKGAGRGFNVNIPWN- 683
Query: 322 HLQSYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMKQGGFRFKGLVVISAGFDASEYE 381
+ + E+ +Q + I A EF LV++SAGFDA+ +
Sbjct: 684 --KKGMGDLEYALAFQ---QLIMPIAYEFNPQ--------------LVLVSAGFDAAIGD 724
Query: 382 QQSMQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISVMEGGYSDGAIA 430
V Y + T LA +G+II +EGGY+ +I+
Sbjct: 725 PLG----GCKVTAEGYGMLTHWLSALA----SGRIIVCLEGGYNVNSIS 765
Score = 60.8 bits (146), Expect = 7e-09
Identities = 60/255 (23%), Positives = 102/255 (39%), Gaps = 65/255 (25%)
Query: 180 ANRAFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQD 239
A IRPPGHH+ + +G+C NN +A ++A + + + +I+D+D+HHG GTQ
Sbjct: 149 AQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQ- 207
Query: 240 ICWKRAGFRPDEFSTDAEHGASEDDNKYDEFGKSFAEFPKVGYFSLH--DINSFPTELGY 297
+ F P+V YFS+H + SF L
Sbjct: 208 --------------------------------RFFYNDPRVVYFSIHRFEHGSFWPHLHE 235
Query: 298 ATKENIRNASTCIMDAHDINIWNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLE 357
+ I + + + +NV L + + Y +IF + LE
Sbjct: 236 SDYHAIGSGAGTGYN------FNVPLNA-------TGMTNGDYLAIF---QQLLLPVALE 279
Query: 358 MKQGGFRFKGLVVISAGFDASEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHSNGKII 417
+ L+++SAG+DA+ + V + Y L+LA + ++
Sbjct: 280 FQ------PELIIVSAGYDAA----LGCPEGEMEVTPACYPHLLNPLLRLA----DARVA 325
Query: 418 SVMEGGYSDGAIASG 432
V+EGGY ++A G
Sbjct: 326 VVLEGGYCLDSLAEG 340
>Hs5174481 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1084
Score = 73.2 bits (178), Expect = 1e-12
Identities = 73/292 (25%), Positives = 119/292 (40%), Gaps = 68/292 (23%)
Query: 144 GDIYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTAN--RAFIAIRPPGHHSHASTPSG 201
G + + TI S GA + V + + V T F +RPPGHH+ STP G
Sbjct: 752 GGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMG 811
Query: 202 FCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWKRAGFRPDEFSTDAEHGAS 261
FC N+ +A + ++ V+ +I+D+D+HHG+GTQ
Sbjct: 812 FCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQ----------------------- 848
Query: 262 EDDNKYDEFGKSFAEFPKVGYFSLH---DINSFPTELGYATKENIRNASTCIMDAHDINI 318
++F P V Y SLH D N FP G + + ++N+
Sbjct: 849 ----------QAFYSDPSVLYMSLHRYDDGNFFP---GSGAPDEVGTGPGV---GFNVNM 892
Query: 319 -WNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMKQGGFRFKGLVVISAGFDA 377
+ L + E++ ++T I A EF + +V++S+GFDA
Sbjct: 893 AFTGGLDPPMGDAEYLAAFRTVVMPI---ASEFAPD--------------VVLVSSGFDA 935
Query: 378 SEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISVMEGGYSDGAI 429
E + +N++ + TK + LA G+I+ +EGG+ AI
Sbjct: 936 VEGHPTPLGGYNLS--ARCFGYLTKQLMGLA----GGRIVLALEGGHDLTAI 981
>Hs4885531 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1122
Score = 69.7 bits (169), Expect = 1e-11
Identities = 67/285 (23%), Positives = 118/285 (40%), Gaps = 65/285 (22%)
Query: 146 IYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRAFIAIRPPGHHSHASTPSGFCLL 205
++ H+ +A+ ++G L ++ F+ + E F IRPPGHH+ ST GFC
Sbjct: 791 VWNEMHSSSAVRMAVGCL---LELAFKVAAGE--LKNGFAIIRPPGHHAEESTAMGFCFF 845
Query: 206 NNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWKRAGFRPDEFSTDAEHGASEDDN 265
N+ I + +K +V +I+D+D+HHG+GTQ
Sbjct: 846 NSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQ--------------------------- 878
Query: 266 KYDEFGKSFAEFPKVGYFSLHDINSFPTELGYATKENIRNASTCIMDAHDINI-WNVHLQ 324
++F P V Y SLH ++ G E + +++N+ W +
Sbjct: 879 ------QAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGV---GYNVNVAWTGGVD 929
Query: 325 SYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMKQGGFRFKGLVVISAGFDASEYEQQS 384
+ E++ ++T I A EF + +V++SAGFDA E
Sbjct: 930 PPIGDVEYLTAFRTVVMPI---AHEFSPD--------------VVLVSAGFDAVEGHLSP 972
Query: 385 MQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISVMEGGYSDGAI 429
+ ++V + T+ + LA G+++ +EGG+ AI
Sbjct: 973 LGGYSVT--ARCFGHLTRQLMTLA----GGRVVLALEGGHDLTAI 1011
>Hs21237799 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1037
Score = 69.7 bits (169), Expect = 1e-11
Identities = 67/285 (23%), Positives = 118/285 (40%), Gaps = 65/285 (22%)
Query: 146 IYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRAFIAIRPPGHHSHASTPSGFCLL 205
++ H+ +A+ ++G L ++ F+ + E F IRPPGHH+ ST GFC
Sbjct: 706 VWNEMHSSSAVRMAVGCL---LELAFKVAAGE--LKNGFAIIRPPGHHAEESTAMGFCFF 760
Query: 206 NNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWKRAGFRPDEFSTDAEHGASEDDN 265
N+ I + +K +V +I+D+D+HHG+GTQ
Sbjct: 761 NSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQ--------------------------- 793
Query: 266 KYDEFGKSFAEFPKVGYFSLHDINSFPTELGYATKENIRNASTCIMDAHDINI-WNVHLQ 324
++F P V Y SLH ++ G E + +++N+ W +
Sbjct: 794 ------QAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGV---GYNVNVAWTGGVD 844
Query: 325 SYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMKQGGFRFKGLVVISAGFDASEYEQQS 384
+ E++ ++T I A EF + +V++SAGFDA E
Sbjct: 845 PPIGDVEYLTAFRTVVMPI---AHEFSPD--------------VVLVSAGFDAVEGHLSP 887
Query: 385 MQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISVMEGGYSDGAI 429
+ ++V + T+ + LA G+++ +EGG+ AI
Sbjct: 888 LGGYSVT--ARCFGHLTRQLMTLA----GGRVVLALEGGHDLTAI 926
>7292853 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1235
Score = 69.7 bits (169), Expect = 1e-11
Identities = 63/254 (24%), Positives = 108/254 (41%), Gaps = 73/254 (28%)
Query: 184 FIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKY-DVTHAVILDFDLHHGDGTQDICW 242
F +RPPGHH+ A+ GFC N+ IA + ++ +V +I+D+D+HHG+GTQ
Sbjct: 959 FAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQ---- 1014
Query: 243 KRAGFRPDEFSTDAEHGASEDDNKYDEFGKSFAEFPKVGYFSLH---DINSFPTELGYAT 299
++F + P + Y S+H D N FP G
Sbjct: 1015 -----------------------------QAFYQSPDILYLSIHRHDDGNFFPGTGG--- 1042
Query: 300 KENIRNASTCIMDA---HDINI-WNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFKNAK 355
+ C A ++NI W+ L + E++ ++T I +
Sbjct: 1043 ------PTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFN------- 1089
Query: 356 LEMKQGGFRFKGLVVISAGFDASEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHSNGK 415
+V++S+GFDA+ + ++V+ + + T++ L+LA NGK
Sbjct: 1090 ----------PDIVLVSSGFDAATGHPAPLGGYHVS--PACFGFMTRELLQLA----NGK 1133
Query: 416 IISVMEGGYSDGAI 429
++ +EGGY AI
Sbjct: 1134 VVLALEGGYDLAAI 1147
>Hs13259524 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 912
Score = 68.6 bits (166), Expect = 3e-11
Identities = 64/250 (25%), Positives = 104/250 (41%), Gaps = 66/250 (26%)
Query: 184 FIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWK 243
F +RPPGHH+ ST GFC N+ IA ++ + +I+D+D+HHG+GTQ
Sbjct: 621 FAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQ----- 675
Query: 244 RAGFRPDEFSTDAEHGASEDDNKYDEFGKSFAEFPKVGYFSLH---DINSFPTELGYATK 300
++F + P V Y SLH D N FP G
Sbjct: 676 ----------------------------QTFYQDPSVLYISLHRHDDGNFFP---GSGAV 704
Query: 301 ENIRNASTCIMDAHDINI-WNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMK 359
+ + S + ++N+ W L + E++ ++ I A EF +
Sbjct: 705 DEVGAGSG---EGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPI---AREFSPD------ 752
Query: 360 QGGFRFKGLVVISAGFDASEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISV 419
LV++SAGFDA+E + ++V+ + T+ + LA G ++
Sbjct: 753 --------LVLVSAGFDAAEGHPAPLGGYHVS--AKCFGYMTQQLMNLA----GGAVVLA 798
Query: 420 MEGGYSDGAI 429
+EGG+ AI
Sbjct: 799 LEGGHDLTAI 808
>Hs13259522 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 952
Score = 68.6 bits (166), Expect = 3e-11
Identities = 64/250 (25%), Positives = 104/250 (41%), Gaps = 66/250 (26%)
Query: 184 FIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWK 243
F +RPPGHH+ ST GFC N+ IA ++ + +I+D+D+HHG+GTQ
Sbjct: 661 FAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQ----- 715
Query: 244 RAGFRPDEFSTDAEHGASEDDNKYDEFGKSFAEFPKVGYFSLH---DINSFPTELGYATK 300
++F + P V Y SLH D N FP G
Sbjct: 716 ----------------------------QTFYQDPSVLYISLHRHDDGNFFP---GSGAV 744
Query: 301 ENIRNASTCIMDAHDINI-WNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMK 359
+ + S + ++N+ W L + E++ ++ I A EF +
Sbjct: 745 DEVGAGSG---EGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPI---AREFSPD------ 792
Query: 360 QGGFRFKGLVVISAGFDASEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISV 419
LV++SAGFDA+E + ++V+ + T+ + LA G ++
Sbjct: 793 --------LVLVSAGFDAAEGHPAPLGGYHVS--AKCFGYMTQQLMNLA----GGAVVLA 838
Query: 420 MEGGYSDGAI 429
+EGG+ AI
Sbjct: 839 LEGGHDLTAI 848
>CE20787 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 782
Score = 68.2 bits (165), Expect = 4e-11
Identities = 28/63 (44%), Positives = 39/63 (61%)
Query: 175 SVEQTANRAFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHG 234
++E + F +RPPGHHS+ G+C+ NN IA +YA EK +V I+DFD H G
Sbjct: 390 AMEGKIHNGFAMVRPPGHHSYGKVAQGYCIFNNVAIAAKYAIEKLEVKKVAIVDFDYHAG 449
Query: 235 DGT 237
+GT
Sbjct: 450 NGT 452
>CE08062 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 796
Score = 65.9 bits (159), Expect = 2e-10
Identities = 61/252 (24%), Positives = 92/252 (36%), Gaps = 67/252 (26%)
Query: 177 EQTANRAFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHA--VILDFDLHHG 234
E F IRPPGHH+ GFC NN +A++ KY A I+D+D+HHG
Sbjct: 522 EGRLKNGFACIRPPGHHAEHEQAMGFCFFNNVAVAVKVLQTKYPAQCAKIAIIDWDVHHG 581
Query: 235 DGTQDICWKRAGFRPDEFSTDAEHGASEDDNKYDEFGKSFAEFPKVGYFSL--HDINSFP 292
+GTQ SF P V Y SL HD +F
Sbjct: 582 NGTQ---------------------------------LSFENDPNVLYMSLHRHDKGNFF 608
Query: 293 TELGYATKENIRNASTCIMDAHDINIWNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFK 352
G T+ DA + + + E++ ++T + A F
Sbjct: 609 PGTGSVTEVGKN-------DAKGLTVNVPFSGDVMRDPEYLAAWRTVIEPVMASFCPDF- 660
Query: 353 NAKLEMKQGGFRFKGLVVISAGFDASEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHS 412
+++SAGFDA ++ + V + TK L ++
Sbjct: 661 ----------------IIVSAGFDACHGHPNALGGYEVT--PEMFGYMTKSLLN----YA 698
Query: 413 NGKIISVMEGGY 424
+GK++ +EGGY
Sbjct: 699 SGKVVLALEGGY 710
>Hs17158041 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 879
Score = 63.9 bits (154), Expect = 8e-10
Identities = 29/82 (35%), Positives = 46/82 (55%), Gaps = 2/82 (2%)
Query: 159 SIGALEIGVDSIFQGVSVEQTAN--RAFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAF 216
S GA + V + + S + F +RPPGHH+ ST GFC N+ I +Y
Sbjct: 747 SSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLR 806
Query: 217 EKYDVTHAVILDFDLHHGDGTQ 238
++ +++ +I+D D+HHG+GTQ
Sbjct: 807 DQLNISKILIVDLDVHHGNGTQ 828
>At5g61060 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 717
Score = 63.9 bits (154), Expect = 8e-10
Identities = 63/251 (25%), Positives = 107/251 (42%), Gaps = 29/251 (11%)
Query: 184 FIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEK---YDVTHAVILDFDLHHGDGTQDI 240
F +RPPGHH+ A GFCL NN +A + + V +I+D+D+HHG+GTQ +
Sbjct: 149 FAIVRPPGHHAEADEAMGFCLFNNVAVAASFLLNERPDLGVKKILIVDWDVHHGNGTQKM 208
Query: 241 CWKRAGFRPDEFSTDAEHGASEDDNKYDEFGKSFAEFPKVGYFSLHDINSFPTELGYATK 300
WK P +S D + G +F + G F + +G
Sbjct: 209 FWKDPR-EPTFYSIT----PLLDFYAWKVTGNAFLVRHEYGGFYPAGDDGDYNMVGEGPG 263
Query: 301 ENIRNASTCIMDAHDINI-WNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMK 359
E +IN+ W+ Q + +++ + + A EF N +
Sbjct: 264 EGF-----------NINVPWD---QGRCGDADYLAAWD---HILIPVAREF--NPDVIFL 304
Query: 360 QGGFRFKGLVVISAGFDASEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISV 419
GF G V G+ ++ ++ +++ P+ + L +LK+A + GKI+
Sbjct: 305 SAGFDAGGCCVTPYGYSVM-LKKVGVEVNSLFCPSFVFALQGSPSLKIALLALAGKIVLA 363
Query: 420 MEGGYSDGAIA 430
+EGGY+ +IA
Sbjct: 364 LEGGYNLDSIA 374
>Hs13128864 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 1215
Score = 62.8 bits (151), Expect = 2e-09
Identities = 24/52 (46%), Positives = 36/52 (69%)
Query: 187 IRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQ 238
IRPPGHH+ S G+C+ N+ +A YA +K+ + +I+D+D+HHG GTQ
Sbjct: 210 IRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQ 261
Score = 58.5 bits (140), Expect = 3e-08
Identities = 73/297 (24%), Positives = 112/297 (37%), Gaps = 75/297 (25%)
Query: 142 NVGDIYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRAFIAIRPPGHHSHASTPSG 201
N IY+ T A + + GA V+++ G + A +RPPGHH+ G
Sbjct: 565 NFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAA-----VVRPPGHHAEQDAACG 619
Query: 202 FCLLNNAHIAIEYAFE-KYDVTHAVILDFDLHHGDGTQDICWKRAGFRPDEFSTDAEHGA 260
FC N+ +A +A +I+D+D+HHG+GTQ +
Sbjct: 620 FCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHM-------------------- 659
Query: 261 SEDDNKYDEFGKSFAEFPKVGYFSLHDINS---FPTELGYATKENIRNASTCIMDAHDIN 317
F + P V Y SLH + FP A+ + R A T +N
Sbjct: 660 -------------FEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGT----GFTVN 702
Query: 318 I-WNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFKNAKLEMKQGGFRFKGLVVISAGFD 376
+ WN D +R + A EF LV++SAGFD
Sbjct: 703 VAWNGPRMGDAD------YLAAWHRLVLPIAYEFNPE--------------LVLVSAGFD 742
Query: 377 ASEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHSNGKIISVMEGGYSDGAIASGV 433
A+ + V Y T + LA +G+II ++EGGY+ +I+ +
Sbjct: 743 AARGDPLG----GCQVSPEGYAHLTHLLMGLA----SGRIILILEGGYNLTSISESM 791
>YNL021w [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 706
Score = 62.4 bits (150), Expect = 2e-09
Identities = 67/262 (25%), Positives = 100/262 (37%), Gaps = 63/262 (24%)
Query: 176 VEQTANRAFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKY--DVTHAVILDFDLHH 233
VE + +RPPGHH+ GFCL +N +A + + Y V +ILD+D+HH
Sbjct: 189 VEGRVKNSLAVVRPPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRIMILDWDIHH 248
Query: 234 GDGTQDICWKRAGFRPDEFSTDAEHGASEDDNKYDEFGKSFAEFPKVGYFSLHDINSFPT 293
G+GTQ KSF + +V Y SLH
Sbjct: 249 GNGTQ---------------------------------KSFYQDDQVLYVSLHRF----- 270
Query: 294 ELGYATKENIRNASTCIMDAHDINIWNVHLQSYKDEEEFVKLYQTKYRSIFAKADEFFKN 353
E+G I+ + Q+ + + E T A+ +
Sbjct: 271 EMGKYYPGTIQGQ---------------YDQTGEGKGEGFNCNITWPVGGVGDAEYMWAF 315
Query: 354 AKLEMKQGGFRFKGLVVISAGFDASEYEQQSMQRHNVNVPTSFYNLFTKDALKLAQMHSN 413
++ M G LV+IS+GFDA++ + +V S Y T LA+
Sbjct: 316 EQVVMPMGREFKPDLVIISSGFDAADGDTIG----QCHVTPSCYGHMTHMLKSLAR---- 367
Query: 414 GKIISVMEGGYSDGAIASGVFS 435
G + V+EGGY+ AIA S
Sbjct: 368 GNLCVVLEGGYNLDAIARSALS 389
>SPBC800.03 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 687
Score = 61.6 bits (148), Expect = 4e-09
Identities = 24/58 (41%), Positives = 36/58 (61%), Gaps = 2/58 (3%)
Query: 183 AFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKY--DVTHAVILDFDLHHGDGTQ 238
AF +RPPGHH+ P GFCL NN + +++ + +I+D+D+HHG+GTQ
Sbjct: 185 AFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQ 242
>Hs20070354 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 669
Score = 60.5 bits (145), Expect = 9e-09
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 5/93 (5%)
Query: 146 IYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRAFIAIRPPGHHSHASTPSGFCLL 205
IY T + GA VD++ G +RPPGHH + +GFC+
Sbjct: 93 IYFHPSTFHCARLAAGAGLQLVDAVLTGA-----VQNGLALVRPPGHHGQRAAANGFCVF 147
Query: 206 NNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQ 238
NN IA +A +K+ + +++D+D+HHG G Q
Sbjct: 148 NNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180
>At1g08460 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 377
Score = 60.1 bits (144), Expect = 1e-08
Identities = 22/57 (38%), Positives = 36/57 (62%)
Query: 183 AFIAIRPPGHHSHASTPSGFCLLNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQD 239
A+ +RPPGHHS + G+C LNNA +A++ A + ++D D+H+G+GT +
Sbjct: 135 AYALVRPPGHHSQPTQADGYCFLNNAALAVKLALNSGSCSRVAVIDIDVHYGNGTAE 191
>At3g18520 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 561
Score = 58.2 bits (139), Expect = 4e-08
Identities = 33/96 (34%), Positives = 48/96 (49%), Gaps = 6/96 (6%)
Query: 145 DIYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRAFIAIRPPGHHSHASTPSGFCL 204
D Y ++++ A + G IF G F +RPPGHH+ GFCL
Sbjct: 243 DTYANEYSARAARLAAGLCADLATDIFTG-----RVKNGFALVRPPGHHAGVRHAMGFCL 297
Query: 205 LNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDI 240
NNA +A A + +I+D+D+HHG+GTQ+I
Sbjct: 298 HNNAAVAALVA-QAAGAKKVLIVDWDVHHGNGTQEI 332
>CE24411 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 517
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/102 (34%), Positives = 52/102 (50%), Gaps = 9/102 (8%)
Query: 145 DIYLSKHTIAALEGSIGALEIGVDSIFQGVSVEQTANRAFIAIRPPGHHSHASTPSGFCL 204
DIY++ T + + GA SI SV IRPPGHH+ GFC+
Sbjct: 96 DIYVNSATWHRAKLAAGA------SIDLMTSVMAAKRPGIAFIRPPGHHAMPDEGCGFCI 149
Query: 205 LNNAHIAIEYAFEKYDVTHAVILDFDLHHGDGTQDICWKRAG 246
NN IA + A + + +I+D+D+H G+GTQ+ C ++ G
Sbjct: 150 FNNVAIAAKAAIQ--NGQKVLIVDYDVHAGNGTQE-CVEQMG 188
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,393,472
Number of Sequences: 60738
Number of extensions: 1653225
Number of successful extensions: 4355
Number of sequences better than 1.0e-05: 23
Number of HSP's better than 0.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 4282
Number of HSP's gapped (non-prelim): 53
length of query: 715
length of database: 30,389,216
effective HSP length: 114
effective length of query: 601
effective length of database: 23,465,084
effective search space: 14102515484
effective search space used: 14102515484
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)