ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0256 suspect: Pn Z KOG0161 Cytoskeleton Myosin class II heavy chain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0256 84729 83329 -467
(467 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
CE09349 [Z] KOG0161 Myosin class II heavy chain 63 8e-10
Hs4506751 [ZR] KOG4568 Cytoskeleton-associated protein and relat... 62 2e-09
Hs12667788 [Z] KOG0161 Myosin class II heavy chain 61 3e-09
YNL250w [L] KOG0962 DNA repair protein RAD50 ABC-type ATPase/SMC... 61 4e-09
Hs15313972 [Z] KOG0161 Myosin class II heavy chain 60 7e-09
YDL058w [U] KOG0946 ER-Golgi vesicle-tethering protein p115 60 9e-09
Hs8923940 [Z] KOG0161 Myosin class II heavy chain 60 9e-09
Hs11024712 [Z] KOG0161 Myosin class II heavy chain 60 9e-09
7298379 [ZR] KOG4568 Cytoskeleton-associated protein and related... 60 9e-09
Hs11342672 [Z] KOG0161 Myosin class II heavy chain 59 1e-08
Hs7669506 [Z] KOG0161 Myosin class II heavy chain 58 3e-08
SPAC1F3.06c [S] KOG4674 Uncharacterized conserved coiled-coil pr... 58 3e-08
Hs4557773 [Z] KOG0161 Myosin class II heavy chain 58 3e-08
Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin 58 3e-08
Hs4759044 [T] KOG0612 Rho-associated coiled-coil containing prot... 57 6e-08
Hs20536595 [T] KOG0612 Rho-associated coiled-coil containing pro... 57 6e-08
Hs20558376 [Z] KOG0161 Myosin class II heavy chain 56 1e-07
YIL149c [S] KOG4674 Uncharacterized conserved coiled-coil protein 56 1e-07
Hs4507659 [S] KOG4674 Uncharacterized conserved coiled-coil protein 56 1e-07
Hs4758200 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific prote... 55 2e-07
CE27133 [Z] KOG0161 Myosin class II heavy chain 55 2e-07
YKR095w [S] KOG4674 Uncharacterized conserved coiled-coil protein 55 2e-07
Hs11321579 [Z] KOG0161 Myosin class II heavy chain 55 2e-07
CE04618 [Z] KOG0161 Myosin class II heavy chain 55 2e-07
Hs7661992 [KRT] KOG4572 Predicted DNA-binding transcription fact... 55 3e-07
Hs5032287 [NTZ] KOG4286 Dystrophin-like protein 55 3e-07
Hs5032285 [NTZ] KOG4286 Dystrophin-like protein 55 3e-07
Hs5032283 [NTZ] KOG4286 Dystrophin-like protein 55 3e-07
Hs5032281 [NTZ] KOG4286 Dystrophin-like protein 55 3e-07
Hs14735371 [S] KOG4725 Uncharacterized conserved protein 55 3e-07
Hs5453642 [D] KOG0018 Structural maintenance of chromosome prote... 54 4e-07
Hs20542063 [Z] KOG0161 Myosin class II heavy chain 54 4e-07
Hs14764231 [D] KOG0018 Structural maintenance of chromosome prot... 54 4e-07
SPBC146.03c [BD] KOG0996 Structural maintenance of chromosome pr... 54 5e-07
Hs17978507 [Z] KOG0161 Myosin class II heavy chain 54 5e-07
7298332 [BD] KOG0996 Structural maintenance of chromosome protei... 54 7e-07
Hs14149661 [U] KOG4809 Rab6 GTPase-interacting protein involved ... 53 9e-07
CE21149 [L] KOG0962 DNA repair protein RAD50 ABC-type ATPase/SMC... 53 9e-07
SPCC162.08c [S] KOG4674 Uncharacterized conserved coiled-coil pr... 52 1e-06
Hs4505301 [Z] KOG0161 Myosin class II heavy chain 52 1e-06
YJL074c [D] KOG0964 Structural maintenance of chromosome protein... 52 2e-06
Hs22045440 [T] KOG0612 Rho-associated coiled-coil containing pro... 52 2e-06
Hs14772793 [Z] KOG0161 Myosin class II heavy chain 52 2e-06
7292701_2 [S] KOG4415 Uncharacterized conserved protein 52 2e-06
CE27954 [Z] KOG0613 Projectin/twitchin and related proteins 51 3e-06
Hs4503613 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific prote... 51 4e-06
Hs13124879 [Z] KOG0161 Myosin class II heavy chain 51 4e-06
Hs13124877 [Z] KOG0161 Myosin class II heavy chain 51 4e-06
Hs13124875 [Z] KOG0161 Myosin class II heavy chain 51 4e-06
Hs5032291 [NTZ] KOG4286 Dystrophin-like protein 50 6e-06
Hs5032289 [NTZ] KOG4286 Dystrophin-like protein 50 6e-06
CE24961 [DY] KOG0977 Nuclear envelope protein lamin intermediate... 50 6e-06
CE15746 [DY] KOG0977 Nuclear envelope protein lamin intermediate... 50 6e-06
Hs4505993 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific prote... 50 7e-06
7301097 [D] KOG0018 Structural maintenance of chromosome protein... 50 9e-06
>CE09349 [Z] KOG0161 Myosin class II heavy chain
Length = 1963
Score = 63.2 bits (152), Expect = 8e-10
Identities = 75/293 (25%), Positives = 137/293 (46%), Gaps = 31/293 (10%)
Query: 20 KKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQQ 79
++LE +N ++K ++ SL K++ K+ + S KL E + K +
Sbjct: 856 EELEKINDKVKALED--SLAKEE----KLRKELEESSAKLVEEKTSLFTNLESTKTQLSD 909
Query: 80 IHDQIKFLDAQIKRKS---GEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEER 136
+++ L+AQ K S E+ND + N+ Q ++ E + E + +E
Sbjct: 910 AEERLAKLEAQQKDASKQLSELNDQLADNEDRTADVQRAKKKIEAEVEALKKQIQDLEMS 969
Query: 137 LRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNAS--NPKEVAAKF-ETIQG 193
LR E + K SKD Q+ +S+++E +Q D +LN + +E+ K E +Q
Sbjct: 970 LRKAESE---KQSKDHQI-----RSLQDEMQQQDEAIAKLNKEKKHQEEINRKLMEDLQS 1021
Query: 194 QINNLNSKNQVVYDKRKTLITKRSALYNK---RDEIYTQIRKIRGDF----DNEFKSFKK 246
+ + N +N+V +TL +L + R ++ Q RK+ G+ +N +S ++
Sbjct: 1022 EEDKGNHQNKVKAKLEQTLDDLEDSLEREKRARADLDKQKRKVEGELKIAQENIDESGRQ 1081
Query: 247 KLD-EQRLKREEDE--KLSKILEDKEEKVGKLQERLNHAKQPAFTFELESIEN 296
+ D E LK++E E +S LED++ V KLQ ++ + E E +EN
Sbjct: 1082 RHDLENNLKKKESELHSVSSRLEDEQALVSKLQRQIKDGQSRISELE-EELEN 1133
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/308 (20%), Positives = 138/308 (44%), Gaps = 49/308 (15%)
Query: 12 KPDVTVRDKKLEPLNVQLKKIDQELSLIKQQI-DNTDFSKDAKNSKEKLQGELKEVIKTQ 70
K ++ +++L L Q K ++LS + Q+ DN D + D + +K+K++ E++ + K
Sbjct: 904 KTQLSDAEERLAKLEAQQKDASKQLSELNDQLADNEDRTADVQRAKKKIEAEVEALKKQI 963
Query: 71 SDLKAKRQQIHDQIKFLDAQIKRKSGEI---NDLVGK-NKKFQNVGQIKQRLAEIDDEIA 126
DL+ ++ + + D QI+ E+ ++ + K NK+ ++ +I ++L E D +
Sbjct: 964 QDLEMSLRKAESEKQSKDHQIRSLQDEMQQQDEAIAKLNKEKKHQEEINRKLME--DLQS 1021
Query: 127 SGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDA--------------- 171
D + +++ K Q+L L + + R ++++K +++
Sbjct: 1022 EEDKGNHQNKVKAKLEQTLDDLEDSLEREKRARADLDKQKRKVEGELKIAQENIDESGRQ 1081
Query: 172 -------LKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRD 224
LKK+ S V+++ E Q ++ L + + D + + L N+R
Sbjct: 1082 RHDLENNLKKK--ESELHSVSSRLEDEQALVSKLQRQ---IKDGQSRISELEEELENER- 1135
Query: 225 EIYTQIRKIRGDFDNEFKSFKKKLDEQ--------RLKREEDEKLSKILEDKEEKVGKLQ 276
+ ++ + + D E + +KLDEQ + ++ + +L+K+ D EE
Sbjct: 1136 QSRSKADRAKSDLQRELEELGEKLDEQGGATAAQVEVNKKREAELAKLRRDLEE------ 1189
Query: 277 ERLNHAKQ 284
+NH Q
Sbjct: 1190 ANMNHENQ 1197
>Hs4506751 [ZR] KOG4568 Cytoskeleton-associated protein and related proteins
Length = 1427
Score = 62.0 bits (149), Expect = 2e-09
Identities = 71/318 (22%), Positives = 151/318 (47%), Gaps = 38/318 (11%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKE----KLQGELKEVIKT 69
++ ++++ +E L ++L K ++ S +++ I+ D + A+ S++ K + E KE+ +
Sbjct: 939 ELRLKERDVEELQLKLTKANENASFLQKSIE--DMTVKAEQSQQEAAKKHEEEKKELERK 996
Query: 70 QSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIA--- 126
SDL+ K + H+Q + L A+ +R + E K K + + +++ L + +D++
Sbjct: 997 LSDLEKKMETSHNQCQELKARYERATSET-----KTKHEEILQNLQKTLLDTEDKLKGAR 1051
Query: 127 ---SGDLSLVEERLRVKEMQSLHKLSKD-FQVVEPIRK-------SIEEEKEQIDALKKE 175
SG L +EE + + + ++D Q++E + K S+E+ K+ L+ E
Sbjct: 1052 EENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1111
Query: 176 LNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEI------YTQ 229
L+ + E + L +NQ + + RK + T + A K ++ +
Sbjct: 1112 LDTLKENNL-KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK 1170
Query: 230 IRKIRGDFDNEFKSFKKKLDEQRLKR----EEDEKLSKILEDKEEKVGKLQERLN--HAK 283
+ + G +E S +K +E+ + E ++ SK ++D +E+ LQ+ ++ A
Sbjct: 1171 LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1230
Query: 284 QPAFTFELESIENMLTVL 301
ELE + N +TVL
Sbjct: 1231 LTEKDAELEKLRNEVTVL 1248
Score = 57.8 bits (138), Expect = 3e-08
Identities = 75/371 (20%), Positives = 163/371 (43%), Gaps = 62/371 (16%)
Query: 19 DKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQ 78
+ K++ L ++ D+E + Q++ + K E LQ ++E T+ DL+ + +
Sbjct: 407 EAKMDQLRTMVEAADREKVELLNQLE------EEKRKVEDLQFRVEEESITKGDLETQTK 460
Query: 79 QIHDQIKFLDAQI---KRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEE 135
H +IK L+ + K K+ ++ + ++ + V + K R+ E++ ++A + E
Sbjct: 461 LEHARIKELEQSLLFEKTKADKLQREL-EDTRVATVSE-KSRIMELEKDLALRVQEVAEL 518
Query: 136 RLRVKEMQ-------SLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNA---SNPKEVA 185
R R++ + SL L + + E + + + + +I +LK+ A ++ KE+
Sbjct: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 578
Query: 186 AKF----------ETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKR------------ 223
A + E+++ ++ + N +N V K+ + A + +
Sbjct: 579 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638
Query: 224 -------DEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKREED-----EKLSKILEDKEEK 271
E+ TQI K+R D+ +E ++ + + D +R ++ KL K++++KE
Sbjct: 639 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698
Query: 272 VGKLQERLNHAKQPAFT------FELESIENMLTVLDPTYVKPVKNVLGIDFGSTSQQTA 325
+ ++ +L+ A+ +L+ E + L+ K + ID TSQ A
Sbjct: 699 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID-NFTSQLKA 757
Query: 326 TPTKTVDSEGL 336
T K +D + L
Sbjct: 758 TEEKLLDLDAL 768
>Hs12667788 [Z] KOG0161 Myosin class II heavy chain
Length = 1960
Score = 61.2 bits (147), Expect = 3e-09
Identities = 83/370 (22%), Positives = 167/370 (44%), Gaps = 90/370 (24%)
Query: 3 TARPKQHIQKPDVTVRDKKLEPLNVQLK----KIDQELSLIKQQIDN--TDFSKDAKNSK 56
+AR K ++K + KKLE + L+ K+ +E L++ +I T+ +++ + SK
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSK 1016
Query: 57 -----------------EKLQGELK---EVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSG 96
E+L+ E K E+ KT+ L+ + DQI L AQI
Sbjct: 1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI----A 1072
Query: 97 EINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQS-LHKLSKDFQVV 155
E+ + K ++ +++ LA +++E A +++L +++E++S + +L +D +
Sbjct: 1073 ELKMQLAKKEE-----ELQAALARVEEEAAQKNMAL----KKIRELESQISELQEDLESE 1123
Query: 156 EPIRKSIEEEK----EQIDALKKEL-----NASNPKEVAAKFE---------------TI 191
R E++K E+++ALK EL + + +E+ +K E T
Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTH 1183
Query: 192 QGQINNLNSKNQVVYDK-----------RKTLITKRSALYNKRDEIYTQIRKI---RGDF 237
+ QI + K+ ++ + L + L N+R E+ +++ + +GD
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS 1243
Query: 238 DNEFKSFKKKLDEQRLKREEDEKLSKILEDKEEKVGKLQERLNH---------AKQPAFT 288
+++ K + +L E ++K E E++ L D KV KLQ L++ +K T
Sbjct: 1244 EHKRKKVEAQLQELQVKFNEGERVRTELAD---KVTKLQVELDNVTGLLSQSDSKSSKLT 1300
Query: 289 FELESIENML 298
+ ++E+ L
Sbjct: 1301 KDFSALESQL 1310
>YNL250w [L] KOG0962 DNA repair protein RAD50 ABC-type ATPase/SMC superfamily
Length = 1312
Score = 60.8 bits (146), Expect = 4e-09
Identities = 62/278 (22%), Positives = 125/278 (44%), Gaps = 31/278 (11%)
Query: 16 TVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKA 75
T +K+L+ L K I +ELS+ D + ++ + K+ L+E+ KT SDL+
Sbjct: 800 TYLEKELKDLENSSKTISEELSIYNTSEDGIQTVDELRDQQRKMNDSLRELRKTISDLQM 859
Query: 76 KRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEE 135
++ D +++ S IN + K + + IDD I S ++ +
Sbjct: 860 EK----------DEKVRENSRMINLIKEKELTVSEIESSLTQKQNIDDSIRSKRENINDI 909
Query: 136 RLRVKEMQS-LHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQ 194
RVKE+++ + L + + ++ E++ I K+ ++ + +F+TI +
Sbjct: 910 DSRVKELEARIISLKNKKDEAQSVLDKVKNERD-IQVRNKQKTVADINRLIDRFQTIYNE 968
Query: 195 INNLNSKNQVVYDKRKTLITK-----------RSALYNKRDEIYTQIRKIRGDFDNEFKS 243
+ + +K +D+ +T I + + L K +E+ + RK+ D +NE K+
Sbjct: 969 VVDFEAKG---FDELQTTIKELELNKAQMLELKEQLDLKSNEVNEEKRKL-ADSNNEEKN 1024
Query: 244 FKKKLDEQRLKREEDEKLSKI----LEDKEEKVGKLQE 277
K+ L+ LK + S+I +++ E + K QE
Sbjct: 1025 LKQNLELIELKSQLQHIESEISRLDVQNAEAERDKYQE 1062
>Hs15313972 [Z] KOG0161 Myosin class II heavy chain
Length = 1647
Score = 60.1 bits (144), Expect = 7e-09
Identities = 94/448 (20%), Positives = 187/448 (40%), Gaps = 55/448 (12%)
Query: 21 KLEPLNVQLKKIDQELS-LIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQQ 79
+++ L +QL K ++EL + + D T +A +LQ ++ E+ + KA R +
Sbjct: 748 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 807
Query: 80 IHDQIKFLDAQIKRKSGEINDLVG--------KNKKFQNVGQIKQRLAEIDDEIASGDLS 131
Q + L +++ E+ D + + K+ Q V ++K+ L E E + +
Sbjct: 808 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE---ETKNHEAQ 864
Query: 132 LVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNP--KEVAAKFE 189
+ + +R + +L +LS+ + + + ++E+ K+ ++ KEL ++V A+ E
Sbjct: 865 IQD--MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 922
Query: 190 ----TIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGD---FDNEFK 242
+ Q+ L++K R L K S L N+ D + T + + F +
Sbjct: 923 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 982
Query: 243 SFKKKL-DEQRLKREEDEK---LSKILEDKEEKVGKLQERLNHAKQPAFTFELESIENML 298
S + +L D Q L +EE + LS + EE+ LQE+ ++ E + +
Sbjct: 983 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1042
Query: 299 TVLDPTYVKPVKNVLGIDFGSTSQQTATPTKTV-DSEGLVPIVKEREGXXXXXXXXXXXX 357
+ D K + D G+ K + D+E L ++E+
Sbjct: 1043 QLAD------TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK------------AL 1084
Query: 358 XXXXXXXXXXXLEPSMIALLAELDIRVPLSKG--DVPATVEQLKAKHEDLTAKQPEATEK 415
L+ + L +LD + ++ +QL A+ + ++A+ E ++
Sbjct: 1085 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR 1144
Query: 416 NIAEA-EEQLKKLNL------EYEAKEQ 436
AEA E++ K L+L EAKE+
Sbjct: 1145 AEAEAREKETKALSLARALEEALEAKEE 1172
Score = 57.4 bits (137), Expect = 5e-08
Identities = 60/263 (22%), Positives = 122/263 (45%), Gaps = 10/263 (3%)
Query: 23 EPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNS-----KEKLQGELKEVIKTQSDLKAKR 77
E + +L QEL I +++ ++ +N K+K+Q ++++ + + + R
Sbjct: 578 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 637
Query: 78 QQIHDQIKFLDAQIKRKSGEINDLVGKNKKF-QNVGQIKQRLAEIDDEIASGDLSLVE-E 135
Q++ + +A+IK+ EI L +N KF + ++ R+AE ++A +
Sbjct: 638 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 697
Query: 136 RLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQI 195
++R K+ + L + + E R+ +E+ K ++D +L E+ A+ + ++ Q+
Sbjct: 698 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ-DQIAELQAQIDELKLQL 756
Query: 196 NNLNSKNQVVYDK-RKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLK 254
+ Q + + K +AL R E+ QI +++ DF++E S K ++R
Sbjct: 757 AKKEEELQGALARGDDETLHKNNALKVVR-ELQAQIAELQEDFESEKASRNKAEKQKRDL 815
Query: 255 REEDEKLSKILEDKEEKVGKLQE 277
EE E L LED + QE
Sbjct: 816 SEELEALKTELEDTLDTTAAQQE 838
Score = 50.1 bits (118), Expect = 7e-06
Identities = 57/278 (20%), Positives = 124/278 (44%), Gaps = 40/278 (14%)
Query: 20 KKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDL----KA 75
K+L L Q+K +EL + D + +K S++KL+ E+++ Q +L +A
Sbjct: 1316 KQLRKLQAQMKDYQRELEEARASRD--EIFAQSKESEKKLKSLEAEILQLQEELASSERA 1373
Query: 76 KRQQIHDQIKFLDAQIKRKSGEI-NDLVGKNKKFQNVGQIKQRLAEIDDEIAS--GDLSL 132
+R ++ + D EI N GK+ +++ R+A++++E+ ++ L
Sbjct: 1374 RRHAEQERDELAD--------EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1425
Query: 133 VEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQ 192
+ +R R +Q + L+ + + + ++Q++ KEL AK + ++
Sbjct: 1426 LNDRFRKTTLQ-VDTLNAELAAERSAAQKSDNARQQLERQNKELK--------AKLQELE 1476
Query: 193 GQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQR 252
G + + K K I+ A + +E Q K R + + +KKL E
Sbjct: 1477 GAVKS----------KFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIF 1526
Query: 253 LKREEDEKLSKILEDKEEKVG----KLQERLNHAKQPA 286
++ E++ + + +++ EK +L+ +L A++ A
Sbjct: 1527 MQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEA 1564
>YDL058w [U] KOG0946 ER-Golgi vesicle-tethering protein p115
Length = 1790
Score = 59.7 bits (143), Expect = 9e-09
Identities = 69/330 (20%), Positives = 150/330 (44%), Gaps = 33/330 (10%)
Query: 19 DKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKL---QGELKEVIKTQSDLKA 75
+ KLE LK++ + +K++ K+A +K++L + L+ + K DL A
Sbjct: 1102 ETKLETSEKALKEVKENEEHLKEE--KIQLEKEATETKQQLNSLRANLESLEKEHEDLAA 1159
Query: 76 KRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEI-ASGDLSLVE 134
+ ++ +QI + Q + ++ND + + Q IK++ E++ E+ A S +
Sbjct: 1160 QLKKYEEQIANKERQYNEEISQLNDEITSTQ--QENESIKKKNDELEGEVKAMKSTSEEQ 1217
Query: 135 ERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQ 194
L+ E+ +L + Q+ E +K+ E ++++K + + K + +Q +
Sbjct: 1218 SNLKKSEIDAL-----NLQIKELKKKNETNEASLLESIK------SVESETVKIKELQDE 1266
Query: 195 INNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLK 254
N + + DK K K S K E+ + KI+ + D K E +++
Sbjct: 1267 CNFKEKEVSELEDKLKASEDKNS----KYLELQKESEKIKEELD-------AKTTELKIQ 1315
Query: 255 REEDEKLSKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVLDPTYVKPVKNVLG 314
E+ LSK E E ++ +L++ + ++ A +LE ++N + + + + K + +L
Sbjct: 1316 LEKITNLSKAKEKSESELSRLKKTSSEERKNA-EEQLEKLKNEIQIKNQAFEKE-RKLLN 1373
Query: 315 IDFGSTSQQTATPTKTVDSEGLVPIVKERE 344
+ +Q+ + T++ E L+ + E E
Sbjct: 1374 EGSSTITQEYSEKINTLEDE-LIRLQNENE 1402
Score = 59.7 bits (143), Expect = 9e-09
Identities = 64/324 (19%), Positives = 155/324 (47%), Gaps = 35/324 (10%)
Query: 29 LKKIDQELSLIKQQIDNT-DFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQQIHDQIKFL 87
LKK+++E S K +++ + + K +++ E + ELK ++T ++ +++ K
Sbjct: 1486 LKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMET---IRKSDEKLEQSKKSA 1542
Query: 88 DAQIKRKSGEINDLVGK-NKKFQNVGQIKQRL-----AEIDDEIASGDLSLVEERLRVKE 141
+ IK E +DL+ + N+ +++ ++K +L + + E +L+ +E++R+
Sbjct: 1543 EEDIKNLQHEKSDLISRINESEKDIEELKSKLRIEAKSGSELETVKQELNNAQEKIRINA 1602
Query: 142 MQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSK 201
++ SK +E I + +++++ +I + N + + ++ + ++ ++++ K
Sbjct: 1603 EENTVLKSK----LEDIERELKDKQAEIKS-----NQEEKELLTSRLKELEQELDSTQQK 1653
Query: 202 NQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLK------R 255
Q ++R+ + K ++ DE + D N+ +++K+ DE +K R
Sbjct: 1654 AQKSEEERRAEVRKFQVEKSQLDEKAMLLETKYNDLVNKEQAWKR--DEDTVKKTTDSQR 1711
Query: 256 EEDEKLSKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVLDPTYVKPVKNV--L 313
+E EKL+K L++ + + KL+E E++ + ++T LD K + L
Sbjct: 1712 QEIEKLAKELDNLKAENSKLKEANEDRS------EIDDLMLLVTDLDEKNAKYRSKLKDL 1765
Query: 314 GIDFGSTSQQTATPTKTVDSEGLV 337
G++ S + + + EG V
Sbjct: 1766 GVEISSDEEDDEEDDEEDEEEGQV 1789
Score = 52.0 bits (123), Expect = 2e-06
Identities = 82/360 (22%), Positives = 153/360 (41%), Gaps = 75/360 (20%)
Query: 19 DKKLEPLNVQLKKI----------DQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIK 68
D K L +QL+KI + ELS +K+ +++ K+A+ EKL+ E++ IK
Sbjct: 1306 DAKTTELKIQLEKITNLSKAKEKSESELSRLKKT--SSEERKNAEEQLEKLKNEIQ--IK 1361
Query: 69 TQSDLKAKR----------QQIHDQIKFLDAQIKRKSGEINDLVGKN------------- 105
Q+ K ++ Q+ ++I L+ ++ R E N+L K
Sbjct: 1362 NQAFEKERKLLNEGSSTITQEYSEKINTLEDELIRLQNE-NELKAKEIDNTRSELEKVSL 1420
Query: 106 -------KKFQNVGQIKQRLAEIDDEIASGDLSLVE-ERLRVKEMQSLHKLSKDFQV--- 154
+K + ++ + D+I D L+ ER ++++SL + + Q
Sbjct: 1421 SNDELLEEKQNTIKSLQDEILSYKDKITRNDEKLLSIERDNKRDLESLKEQLRAAQESKA 1480
Query: 155 -VEPIRKSIEEEK-------EQIDALKKELNA---SNPKEVAAKFETIQGQINNLNSKNQ 203
VE K +EEE E+ + K+L + SN E+ + ETI+ L +
Sbjct: 1481 KVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKK 1540
Query: 204 VVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDF------DNEFKSFKKKL----DEQRL 253
+ K L ++S L ++ +E I +++ +E ++ K++L ++ R+
Sbjct: 1541 SAEEDIKNLQHEKSDLISRINESEKDIEELKSKLRIEAKSGSELETVKQELNNAQEKIRI 1600
Query: 254 KREEDEKLSKILEDKEEKVGKLQERL--NHAKQPAFTFELESIENMLTVLDPTYVKPVKN 311
EE+ L LED E ++ Q + N ++ T L+ +E LD T K K+
Sbjct: 1601 NAEENTVLKSKLEDIERELKDKQAEIKSNQEEKELLTSRLKELEQ---ELDSTQQKAQKS 1657
Score = 50.8 bits (120), Expect = 4e-06
Identities = 85/462 (18%), Positives = 196/462 (42%), Gaps = 66/462 (14%)
Query: 11 QKPDVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKL---QGELKEVI 67
++P + +++E L Q K+ E++ ++ + ++T +N EKL E KE+
Sbjct: 721 EEPINKISFEEVEKLQRQCTKLKGEITSLQTETESTH-----ENLTEKLIALTNEHKELD 775
Query: 68 KTQSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVG-------KNKKFQN-VGQIKQRLA 119
+ L + + + L+ ++K ++++ K+K+ Q + + K +
Sbjct: 776 EKYQILNSSHSSLKENFSILETELKNVRDSLDEMTQLRDVLETKDKENQTALLEYKSTIH 835
Query: 120 EIDDEIAS---GDLSLVEERLRVKEM-----QSLHKLSKDFQVVEPIRKSIEEEKEQIDA 171
+ +D I + G +++ ++ + ++ + L LS++ Q VE K++++EK++ +
Sbjct: 836 KQEDSIKTLEKGLETILSQKKKAEDGINKMGKDLFALSREMQAVEENCKNLQKEKDKSNV 895
Query: 172 LKKELNASNPKEVAAKFETIQG----------QINNLNSKNQVVYDKRKTLITKRSALYN 221
++ S +++AAK I+ Q NNL+ + + + K L+ +S +
Sbjct: 896 NHQKETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKEKEHI---SKELVEYKSR-FQ 951
Query: 222 KRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKLSKILEDKEEKVGKLQERLNH 281
D + ++ + N +K + + +E +K E+ K + ++ LQ +++
Sbjct: 952 SHDNLVAKLTEKLKSLANNYKDMQAE-NESLIKAVEESK-----NESSIQLSNLQNKIDS 1005
Query: 282 AKQPAFTFELE--SIENMLTVLDPTYVKPVKNVLGIDFGSTSQQ--TATPTKTVDSEGLV 337
Q F++E SIE + L T D T ++ + + + + E +
Sbjct: 1006 MSQEKENFQIERGSIEKNIEQLKKTI---------SDLEQTKEEIISKSDSSKDEYESQI 1056
Query: 338 PIVKEREGXXXXXXXXXXXXXXXXXXXXXXXLEPSMIA---LLAELDIRVPLSKGDVPAT 394
++KE+ LE + A L EL+ ++ S+
Sbjct: 1057 SLLKEKL-ETATTANDENVNKISELTKTREELEAELAAYKNLKNELETKLETSE----KA 1111
Query: 395 VEQLKAKHEDLTAKQPEATEKNIAEAEEQLKKLNLEYEAKEQ 436
++++K E L ++ + EK E ++QL L E+ E+
Sbjct: 1112 LKEVKENEEHLKEEKIQ-LEKEATETKQQLNSLRANLESLEK 1152
>Hs8923940 [Z] KOG0161 Myosin class II heavy chain
Length = 1941
Score = 59.7 bits (143), Expect = 9e-09
Identities = 70/330 (21%), Positives = 146/330 (44%), Gaps = 64/330 (19%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTD-FSKDAKNSKEKLQGELKEVIKTQSD 72
D+ + K+ L K++Q++ ++ ++ D + +K KL+G+LK ++ D
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQ-NVGQIKQRLAEIDDEI------ 125
++ ++QQ+ +++K + +I +I D + Q + +++ R+ E+++EI
Sbjct: 1075 IENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERAS 1134
Query: 126 ----------ASGDLSLVEERLR------VKEMQSLHKLSKDFQVVEPIRKSIEEEKEQI 169
S +L + ERL +++ K +FQ +R+ +EE Q
Sbjct: 1135 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ---KMRRDLEEATLQH 1191
Query: 170 DALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQ 229
+A L + VA E QI+NL Q L ++S + + D++ +
Sbjct: 1192 EATAATLRKKHADSVAELGE----QIDNLQRVKQ-------KLEKEKSEMKMEIDDLASN 1240
Query: 230 IR---KIRGDFDNEFKSFKKKLDEQRLKREEDEKL------------------SKILEDK 268
+ K +G+ + ++ + +L E + K EE ++L S+ L++K
Sbjct: 1241 VETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK 1300
Query: 269 EEKVGKLQERLNHAKQPAFTFELESIENML 298
E L +L+ KQ AFT ++E ++ L
Sbjct: 1301 E----ALVSQLSRGKQ-AFTQQIEELKRQL 1325
Score = 51.6 bits (122), Expect = 2e-06
Identities = 69/335 (20%), Positives = 144/335 (42%), Gaps = 50/335 (14%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDL 73
D R +L +QL+ +E++ ++ D + + + K KL+ E E+ K DL
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVT--ERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 963
Query: 74 KA--------------KRQQIHDQIKFLDAQIKRKSGE-----------INDLVGKNKKF 108
+ K + + +++ LD I + + E ++DL + K
Sbjct: 964 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1023
Query: 109 QNVGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQ 168
+ + K +L + D++ G L E++LR+ ++ KL D ++ + IE EK+Q
Sbjct: 1024 NTLTKAKIKLEQQVDDL-EGSLE-QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ 1081
Query: 169 ID--ALKKELNASNPK-----------EVAAKFETIQGQINNLNSKNQVVYDKRKTLITK 215
+D KKE SN + ++ K + +Q +I L + + R +
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1141
Query: 216 RSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDE-QRLKREEDE-------KLSKILED 267
RS L + +EI ++ + G + + KK+ E Q+++R+ +E + + +
Sbjct: 1142 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1201
Query: 268 KEEKVGKLQERLNHAKQPAFTFELESIENMLTVLD 302
+ V +L E++++ ++ E E E + + D
Sbjct: 1202 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1236
>Hs11024712 [Z] KOG0161 Myosin class II heavy chain
Length = 1939
Score = 59.7 bits (143), Expect = 9e-09
Identities = 66/327 (20%), Positives = 146/327 (44%), Gaps = 58/327 (17%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTD-FSKDAKNSKEKLQGELKEVIKTQSD 72
D+ + + K+ L K++Q++ ++ ++ D + +K KL+G+LK ++ D
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMD 1072
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQ-NVGQIKQRLAEIDDEI------ 125
+ +QQ+++++K + ++ G+I D + Q + +++ R+ E+++EI
Sbjct: 1073 TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEEEIEAERAS 1132
Query: 126 ----------ASGDLSLVEERLR------VKEMQSLHKLSKDFQVVEPIRKSIEEEKEQI 169
S +L + ERL +++ K +FQ +R+ +EE Q
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIELNKKREAEFQ---KMRRDLEESTLQH 1189
Query: 170 DALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQ 229
+A L + VA + QI++L Q + ++ L + + L + +
Sbjct: 1190 EATAAALRKKHADSVA----ELGKQIDSLQRVKQKLEKEKSELKMEINDLASNME----T 1241
Query: 230 IRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL------------------SKILEDKEEK 271
+ K + +F+ ++ + +L E + K EE ++L S+ L++K+
Sbjct: 1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 272 VGKLQERLNHAKQPAFTFELESIENML 298
V +L+ KQ AFT ++E ++ L
Sbjct: 1302 V----SQLSRGKQ-AFTQQIEELKRQL 1323
>7298379 [ZR] KOG4568 Cytoskeleton-associated protein and related proteins
Length = 1690
Score = 59.7 bits (143), Expect = 9e-09
Identities = 64/298 (21%), Positives = 133/298 (44%), Gaps = 43/298 (14%)
Query: 15 VTVRDKKLEPLNVQLKKIDQELSLIKQQI-DNTDFSKDAKNSKEKLQGELKEVIKTQSDL 73
+ ++ KL NVQL+ L + Q+ ++ K + KL GEL++V + D+
Sbjct: 1254 IEAQNTKLNESNVQLENKTSCLKETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDI 1313
Query: 74 KAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQ--------NVGQIKQRLAEIDDEI 125
K ++ + +K L+ +++ + +++ NK+ Q N G ++ + +++
Sbjct: 1314 KDSLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKL 1373
Query: 126 -----ASGDL--SLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQID-ALKKELN 177
A+G+L +L ++ +KE+Q KL + V+E +KS E +++++ A +KE
Sbjct: 1374 QQLEQANGELKEALCQKENGLKELQG--KLDESNTVLESQKKSHNEIQDKLEQAQQKERT 1431
Query: 178 ASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDF 237
+E +K Q+ N + Q +++ L+ K + +F
Sbjct: 1432 L---QEETSKLAEQLSQLKQANEELQKSLQQKQLLLEKGN------------------EF 1470
Query: 238 DNEFKSFKKKLDEQRLKREEDEKLSKILEDKEEKVGKLQERLNHAKQPAFTFELESIE 295
D + ++K +DE + S +LE + +V +L+ L A T LE+ E
Sbjct: 1471 DTQLAEYQKVIDEM---DDAASVKSALLEQLQNRVAELETALRQANDAQKTAYLETKE 1525
>Hs11342672 [Z] KOG0161 Myosin class II heavy chain
Length = 1940
Score = 59.3 bits (142), Expect = 1e-08
Identities = 68/324 (20%), Positives = 144/324 (43%), Gaps = 52/324 (16%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSK-DAKNSKEKLQGELKEVIKTQSD 72
D+ + K+ LN K++Q++ ++ ++ + D + +K KL+G+LK ++ D
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQ-NVGQIKQRLAEIDDEIASGDLS 131
L+ +QQ+ +++K D + + ++ D +FQ + +++ R+ E+++EI + +
Sbjct: 1070 LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT 1129
Query: 132 LVE-ERLRVKEMQSLHKLSKDFQVVE------------------PIRKSIEEEKEQIDAL 172
+ E+ R + L +LS+ + +R+ +EE Q +A+
Sbjct: 1130 RAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAM 1189
Query: 173 KKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRK 232
L + VA E QI+NL Q + ++ + L + + + K
Sbjct: 1190 VATLRKKHADSVAELGE----QIDNLQRVKQKLEKEKSEFKLEIDDLSSSME----SVSK 1241
Query: 233 IRGDFDNEFKSFKKKLDEQRLKREEDEK------------------LSKILEDKEEKVGK 274
+ + + ++ + +L E R K EE ++ LS+ LE+KE V
Sbjct: 1242 SKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIV-- 1299
Query: 275 LQERLNHAKQPAFTFELESIENML 298
+L+ +KQ AFT + E ++ L
Sbjct: 1300 --SQLSRSKQ-AFTQQTEELKRQL 1320
>Hs7669506 [Z] KOG0161 Myosin class II heavy chain
Length = 1939
Score = 58.2 bits (139), Expect = 3e-08
Identities = 65/323 (20%), Positives = 143/323 (44%), Gaps = 50/323 (15%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTD-FSKDAKNSKEKLQGELKEVIKTQSD 72
D+ + K+ L K++Q++ ++ ++ D + +K KL+G+LK ++ D
Sbjct: 1013 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMD 1072
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQ-NVGQIKQRLAEIDDEI------ 125
++ +QQ+ +++K + ++ +I D + Q + +++ R+ E+++EI
Sbjct: 1073 IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERAS 1132
Query: 126 ----------ASGDLSLVEERLR------VKEMQSLHKLSKDFQVVEPIRKSIEEEKEQI 169
S +L + ERL +++ K +FQ +R+ +EE Q
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ---KMRRDLEEATLQH 1189
Query: 170 DALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQ 229
+A L + VA E QI+NL Q + ++ + + L + +
Sbjct: 1190 EATAATLRKKHADSVAELGE----QIDNLQRVKQKLEKEKSEMKMEIDDLASNME----T 1241
Query: 230 IRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL--------SKILEDKEEKVGKLQER--- 278
+ K +G+ + ++ + +L E + K EE ++L +++ + E +L E+
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 279 ---LNHAKQPAFTFELESIENML 298
L+ KQ AFT ++E ++ L
Sbjct: 1302 VSQLSRGKQ-AFTQQIEELKRQL 1323
>SPAC1F3.06c [S] KOG4674 Uncharacterized conserved coiled-coil protein
Length = 1957
Score = 57.8 bits (138), Expect = 3e-08
Identities = 65/315 (20%), Positives = 136/315 (42%), Gaps = 39/315 (12%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDL 73
+++ +DK ++ ++ QL++ L+ ++ + +D +N K +K+ K + DL
Sbjct: 414 NLSSKDKMVKQVSSQLEEARSSLAHATGKLAEINSERDFQNKK------IKDFEKIEQDL 467
Query: 74 KAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLV 133
+A +++K A I +K E+N+L + K+ + V + Q
Sbjct: 468 RACLNSSSNELKEKSALIDKKDQELNNLREQIKEQKKVSESTQ----------------- 510
Query: 134 EERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNA--SNPKEVAAKFETI 191
SL L +D + +K E + Q++ LK EL SN + ++++ T+
Sbjct: 511 ---------SSLQSLQRD---ILNEKKKHEVYESQLNELKGELQTEISNSEHLSSQLSTL 558
Query: 192 QGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQ 251
+ + N + + + +L T +A K + Q+++ +F + SFKK +
Sbjct: 559 AAEKEAAVATNNELSESKNSLQTLCNAFQEKLAKSVMQLKENEQNFSSLDTSFKKLNESH 618
Query: 252 RLKREEDEKLSKILEDKEEKVGKLQ-ERLN-HAKQPAFTFELESIENMLTVLDPTYVKPV 309
+ + ++K L+D K+ +LQ ER N K+ + E + L L+ + +
Sbjct: 619 QELENNHQTITKQLKDTSSKLQQLQLERANFEQKESTLSDENNDLRTKLLKLEESNKSLI 678
Query: 310 KNVLGIDFGSTSQQT 324
K +D + QT
Sbjct: 679 KKQEDVDSLEKNIQT 693
>Hs4557773 [Z] KOG0161 Myosin class II heavy chain
Length = 1935
Score = 57.8 bits (138), Expect = 3e-08
Identities = 63/324 (19%), Positives = 146/324 (44%), Gaps = 42/324 (12%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSK-DAKNSKEKLQGELKEVIKTQSD 72
D+ + K+ L K++Q++ ++ ++ + D + +K KL+G+LK ++ D
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1068
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQ-NVGQIKQRLAEIDDEIASGDLS 131
L+ +QQ+ +++K D ++ + I D + Q + +++ R+ E+++E+ S +
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELESERTA 1128
Query: 132 LVE-ERLRVKEMQSLHKLSKDFQVV------------------EPIRKSIEEEKEQIDAL 172
+ E+LR + L ++S+ + + +R+ +EE Q +A
Sbjct: 1129 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1188
Query: 173 KKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRK 232
L + VA E QI+NL Q + ++ + + + + QI K
Sbjct: 1189 AAALRKKHADSVAELGE----QIDNLQRVKQKLEKEKSEFKLELDDVTSNME----QIIK 1240
Query: 233 IRGDFDNEFKSFKKKLDEQRLKREEDEKLSKILEDKEEKV----GKLQERLNHAKQPAFT 288
+ + + ++ + +++E R K EE ++ L + K+ G+L +L+
Sbjct: 1241 AKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD-------- 1292
Query: 289 FELESIENMLTVLDPTYVKPVKNV 312
E E++ + LT TY + ++++
Sbjct: 1293 -EKEALISQLTRGKLTYTQQLEDL 1315
>Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1177
Score = 57.8 bits (138), Expect = 3e-08
Identities = 68/274 (24%), Positives = 129/274 (46%), Gaps = 32/274 (11%)
Query: 18 RDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSK-EKLQGELKEVIKTQSDLKAK 76
R ++ E LN Q + +E+ + + N +A N K +++ G L+ D++ K
Sbjct: 475 RIRRQELLN-QKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQ-------DVRLK 526
Query: 77 RQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEER 136
+Q +++ LD Q + EI L + +++QN +L + E L+ ER
Sbjct: 527 KQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN------KLIYLVPE-----KQLLNER 575
Query: 137 LRVKEMQSLHKLSKDFQVVEPIRKSIEEE------KEQIDALKKELNASNPKEVAAKFET 190
+K MQ + ++ +KS+E+E KEQ+DAL+KE AS E+ +
Sbjct: 576 --IKNMQFSNTPDSGVSLLH--KKSLEKEELCQRLKEQLDALEKE-TASKLSEMDSFNNQ 630
Query: 191 IQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDE 250
++ N++ + K K + KR E+ Q +K+ + + K K+ L +
Sbjct: 631 LKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELM-QKKKLEDEAARKAKQGKENLWK 689
Query: 251 QRLKREEDEKLSKILEDKEEKVGKLQERLNHAKQ 284
+ L++EE+EK ++ E+K ++ + +ER KQ
Sbjct: 690 ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ 723
>Hs4759044 [T] KOG0612 Rho-associated coiled-coil containing protein kinase
Length = 1388
Score = 57.0 bits (136), Expect = 6e-08
Identities = 79/367 (21%), Positives = 152/367 (40%), Gaps = 63/367 (17%)
Query: 19 DKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQ 78
+K+ L+ LK+ Q+++ + +Q D ++D +N K++ E ++ TQ+DLK + Q
Sbjct: 758 EKRCSLLDCDLKQSQQKINELLKQKDV--LNEDVRNLTLKIEQETQKRCLTQNDLKMQTQ 815
Query: 79 QIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNV----------GQIKQRLAEIDDEIASG 128
Q+ + +K + Q+K+++ + ++ N + QN GQ+K+ +++ E
Sbjct: 816 QV-NTLKMSEKQLKQENNHLMEM-KMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFS 873
Query: 129 DLSLVEERLRVKEMQSLHKLSKDFQ--------------------------------VVE 156
L + R +E + KL K+ Q + E
Sbjct: 874 TLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAE 933
Query: 157 PIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKR 216
+E+EK + KE+ A + +E+ K TI +L N+ + L ++
Sbjct: 934 EQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIA----SLEETNRTLTSDVANLANEK 989
Query: 217 SALYNKRDEIYTQIRKIRGDFDNEFKSF-------KKKLDEQRLKREEDEKLSKILEDKE 269
L NK ++ Q+ +++ D E + K+ L E+ LK + KL++I+ KE
Sbjct: 990 EELNNKLKDVQEQLSRLK---DEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKE 1046
Query: 270 --EKVGKLQERLNHAKQPAFTFELESIENMLTVLDPTYVKPVKNVLGIDFGSTSQQTATP 327
++ R + EL+S LT Y K + N + SQ
Sbjct: 1047 PVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKEL-NEMQAQIAEESQIRIEL 1105
Query: 328 TKTVDSE 334
T+DS+
Sbjct: 1106 QMTLDSK 1112
>Hs20536595 [T] KOG0612 Rho-associated coiled-coil containing protein kinase
Length = 1388
Score = 57.0 bits (136), Expect = 6e-08
Identities = 79/367 (21%), Positives = 152/367 (40%), Gaps = 63/367 (17%)
Query: 19 DKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQ 78
+K+ L+ LK+ Q+++ + +Q D ++D +N K++ E ++ TQ+DLK + Q
Sbjct: 758 EKRCSLLDCDLKQSQQKINELLKQKDV--LNEDVRNLTLKIEQETQKRCLTQNDLKMQTQ 815
Query: 79 QIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNV----------GQIKQRLAEIDDEIASG 128
Q+ + +K + Q+K+++ + ++ N + QN GQ+K+ +++ E
Sbjct: 816 QV-NTLKMSEKQLKQENNHLMEM-KMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFS 873
Query: 129 DLSLVEERLRVKEMQSLHKLSKDFQ--------------------------------VVE 156
L + R +E + KL K+ Q + E
Sbjct: 874 TLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAE 933
Query: 157 PIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKR 216
+E+EK + KE+ A + +E+ K TI +L N+ + L ++
Sbjct: 934 EQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIA----SLEETNRTLTSDVANLANEK 989
Query: 217 SALYNKRDEIYTQIRKIRGDFDNEFKSF-------KKKLDEQRLKREEDEKLSKILEDKE 269
L NK ++ Q+ +++ D E + K+ L E+ LK + KL++I+ KE
Sbjct: 990 EELNNKLKDVQEQLSRLK---DEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKE 1046
Query: 270 --EKVGKLQERLNHAKQPAFTFELESIENMLTVLDPTYVKPVKNVLGIDFGSTSQQTATP 327
++ R + EL+S LT Y K + N + SQ
Sbjct: 1047 PVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKEL-NEMQAQIAEESQIRIEL 1105
Query: 328 TKTVDSE 334
T+DS+
Sbjct: 1106 QMTLDSK 1112
>Hs20558376 [Z] KOG0161 Myosin class II heavy chain
Length = 1937
Score = 56.2 bits (134), Expect = 1e-07
Identities = 68/331 (20%), Positives = 145/331 (43%), Gaps = 66/331 (19%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTD-FSKDAKNSKEKLQGELKEVIKTQSD 72
D+ + K+ L K++Q++ ++ ++ D + +K KL+G+LK ++ D
Sbjct: 1012 DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMD 1071
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVG-QIKQRLAEIDDEIAS-GDL 130
++ +QQ LD ++++K EI++L+ K + Q V Q+++++ E+ I G+
Sbjct: 1072 MENDKQQ-------LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEE 1124
Query: 131 SLVEERLRVKEMQSLHKLSKDFQVV-------------------------EPIRKSIEEE 165
E R K + LS++ + + + +R+ +EE
Sbjct: 1125 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEA 1184
Query: 166 KEQIDALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDE 225
Q +A+ L + +A E QI+NL Q + ++ L + L + +
Sbjct: 1185 TLQHEAMVAALRKKHADSMAELGE----QIDNLQRVKQKLEKEKSELKMETDDLSSNAE- 1239
Query: 226 IYTQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL------------------SKILED 267
I K +G+ + +S + ++ E + K EE ++L S+ L++
Sbjct: 1240 ---AISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDE 1296
Query: 268 KEEKVGKLQERLNHAKQPAFTFELESIENML 298
K+ L +L+ +KQ A T ++E +++ L
Sbjct: 1297 KD----ALVSQLSRSKQ-ASTQQIEELKHQL 1322
>YIL149c [S] KOG4674 Uncharacterized conserved coiled-coil protein
Length = 1679
Score = 55.8 bits (133), Expect = 1e-07
Identities = 71/302 (23%), Positives = 135/302 (44%), Gaps = 34/302 (11%)
Query: 12 KPDVTVRDKKL---EPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIK 68
K V++ K+ E Q K+ Q+LS ++ D K N L+G+L
Sbjct: 1219 KEQVSINSNKILVYESEMEQCKQRYQDLSQQQKDAQKKDIEK-LTNEISDLKGKLSSAEN 1277
Query: 69 TQSDLKAK----RQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDE 124
+DL+ K ++Q H++ LDA K+++ N+L + IK +L E D
Sbjct: 1278 ANADLENKFNRLKKQAHEK---LDASKKQQAALTNEL-------NELKAIKDKL-EQDLH 1326
Query: 125 IASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEV 184
+ + ++ +L+ E+QS +S+D + + + E+I++LKKEL
Sbjct: 1327 FENAKVIDLDTKLKAHELQS-EDVSRDHE-----KDTYRTLMEEIESLKKELQIFKTANS 1380
Query: 185 AAK-FETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKS 243
++ FE ++ +N K++++ ++ K K NK + K D + K
Sbjct: 1381 SSDAFEKLK--VNMEKEKDRIIDERTKEFEKKLQETLNKSTSSEAEYSK---DIETLKKE 1435
Query: 244 FKKKLDEQRLKR--EEDEKLSKILE-DKEEKVGKLQERLNHAKQPAFTFELESIENMLTV 300
+ K+ +++ L+R E +E L K + EE++ K+ + + F +L+ LT
Sbjct: 1436 WLKEYEDETLRRIKEAEENLKKRIRLPSEERIQKIISKRKEELEEEFRKKLKENAGSLTF 1495
Query: 301 LD 302
LD
Sbjct: 1496 LD 1497
Score = 50.4 bits (119), Expect = 6e-06
Identities = 59/261 (22%), Positives = 120/261 (45%), Gaps = 21/261 (8%)
Query: 20 KKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQQ 79
K+ + L ++LK+ S I + DFS K K++ + + +SDL++K Q+
Sbjct: 746 KEKKELQMRLKE-----SEISHNENKMDFSSKEGQYKAKIKELENNLERLRSDLQSKIQE 800
Query: 80 IHDQIKFLDAQIKRKSGEINDLVGKNKK-FQNVGQIKQRLAEIDDEIASGDLSLVEERLR 138
I D+Q+K I+D K K + + + ++ EI + D L + + +
Sbjct: 801 IESIRSCKDSQLKWAQNTIDDTEMKMKSLLTELSNKETTIEKLSSEIENLDKELRKTKFQ 860
Query: 139 VKEMQSLHKLSKDFQVVEP-IRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQINN 197
K + + D +EP +RK +E+ + Q+ ++ A +E+ + E ++ N
Sbjct: 861 YKFLDQ----NSDASTLEPTLRKELEQIQVQLKDANSQIQAY--EEIISSNENALIELKN 914
Query: 198 LNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLK-RE 256
+K + YD + L K R+E + ++RG+ E ++ + KL E L +
Sbjct: 915 ELAKTKENYDAKIELEKKEKW---AREE---DLSRLRGEL-GEIRALQPKLKEGALHFVQ 967
Query: 257 EDEKLSKILEDKEEKVGKLQE 277
+ EKL +E ++ + K+++
Sbjct: 968 QSEKLRNEVERIQKMIEKIEK 988
>Hs4507659 [S] KOG4674 Uncharacterized conserved coiled-coil protein
Length = 2349
Score = 55.8 bits (133), Expect = 1e-07
Identities = 64/292 (21%), Positives = 131/292 (43%), Gaps = 41/292 (14%)
Query: 21 KLEPLNVQLKKI---DQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKR 77
+LE LN QLK + ++EL + + + N +KE+L+ E +++I+T L +
Sbjct: 81 ELEKLNNQLKALTEKNKELEIAQDR--NIAIQSQFTRTKEELEAEKRDLIRTNERLSQEL 138
Query: 78 QQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSL-VEER 136
+ + + +K L+ ++K + G+++ +L DE+ + D+S+ E+
Sbjct: 139 EYLTEDVKRLNEKLKESN-------------TTKGELQLKL----DELQASDVSVKYREK 181
Query: 137 LRVKEMQSLHK----LSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQ 192
+E + LH L+ + + ++ EK + L+ + N N KE ++ E
Sbjct: 182 RLEQEKELLHSQNTWLNTELKTKTDELLALGREKGN-EILELKCNLENKKEEVSRLEE-- 238
Query: 193 GQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFK---SFKKKLD 249
Q+N L + N+ + + L+TK L +++ + K + + K +K D
Sbjct: 239 -QMNGLKTSNEHLQKHVEDLLTK---LKEAKEQQASMEEKFHNELNAHIKLSNLYKSAAD 294
Query: 250 EQRLKREE----DEKLSKILEDKEEKVGKLQERLNHAKQPAFTFELESIENM 297
+ K E E+L K+L++ E +Q+ L +Q E E +E +
Sbjct: 295 DSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKI 346
>Hs4758200 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and related
proteins
Length = 2871
Score = 55.5 bits (132), Expect = 2e-07
Identities = 64/321 (19%), Positives = 147/321 (44%), Gaps = 47/321 (14%)
Query: 17 VRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFS-KDAKNSKEKLQGELKEVIKTQSDLKA 75
V++++L L + +++ QE ++ Q I S K+ + K+K++ EL + +T S+
Sbjct: 1530 VQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSC 1589
Query: 76 KRQQIHDQIKFLDAQIKRKSGEINDLVGKNK-----KFQNVGQIKQRLAEIDDEIASGD- 129
KR+++ ++++ + +K ++ +I +L + + K ++ ++Q+ +D +
Sbjct: 1590 KRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQR 1649
Query: 130 -------LSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELN--ASN 180
LS E LR + +Q + + E +K+IE++ ++ K E+ S
Sbjct: 1650 TQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSL 1709
Query: 181 PKEVAAKFETIQGQINNL--------NSKNQVVYDKRKTLITKRSALY---NKRDEIYTQ 229
+ + + ++ ++ NL +++ DK T++ RS L N+ E+
Sbjct: 1710 TENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGL 1769
Query: 230 IRKIRGDFDN---EFKSFKKKLDEQRLKREEDEKLS--------------KILEDKEEKV 272
I ++ + +N E + F+K+ E + +E + K+LE + ++
Sbjct: 1770 INDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARL 1829
Query: 273 GKLQERLNHAKQPAFTFELES 293
+L++ LN AK T E E+
Sbjct: 1830 QRLEDELNRAKS---TLEAET 1847
>CE27133 [Z] KOG0161 Myosin class II heavy chain
Length = 2003
Score = 55.5 bits (132), Expect = 2e-07
Identities = 63/315 (20%), Positives = 126/315 (40%), Gaps = 40/315 (12%)
Query: 3 TARPKQHIQKPDVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGE 62
T + + + + KK+E LN + IDQ L +Q+I A++ E + E
Sbjct: 1196 TVKSSEEVVEEMKAQNQKKIEELN---ETIDQ---LKRQKISADKAKSSAESDNENFRAE 1249
Query: 63 LKEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEID 122
L + + + + KR+ + D +++ ++DL+ K K N + Q+ D
Sbjct: 1250 LSNIASARLEAEKKRKAAETSLMEKDHKMREMQSNLDDLMAKLSKMNNELESIQKAKSAD 1309
Query: 123 DEI--------ASGDLSLVE--------ERLRVKEMQSLHKLSKDFQVV----------- 155
+ + AS D+ L E R R + +L +D V
Sbjct: 1310 ETLNSNLLKKNASLDMQLSELTEASEEDRRTRATLNNKIRQLEEDLAVAVEARDDALDAQ 1369
Query: 156 EPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKR-KTLIT 214
E I K ++E K + +K+L+ N + + + + +++ + + R K
Sbjct: 1370 EKIEKEVKEVKSLLAEARKKLDEENREVMEELRKKKEKELSAEKERADMAEQARDKAERA 1429
Query: 215 KRSALYNKRD--EIYTQIRKIRGDFDNEFKSFKKKLDEQR----LKREEDEKLSKILEDK 268
K+ A+ D + T + + + + + F ++L E+R L ++E + ++L D
Sbjct: 1430 KKKAIQEAEDVQKELTDVVAATREMERKMRKFDQQLAEERNNTLLAQQERDMAHQMLRDA 1489
Query: 269 EEKVGKLQERLNHAK 283
E K L L+ K
Sbjct: 1490 ETKALVLSNELSEKK 1504
Score = 54.7 bits (130), Expect = 3e-07
Identities = 65/297 (21%), Positives = 133/297 (43%), Gaps = 30/297 (10%)
Query: 4 ARPKQHIQKPDVTVRDKKLEPLNVQLKKIDQELSLIKQQ---IDNTDFSKDAKNSKEKLQ 60
AR + + + + + +K + N + + E L ++Q ++ T +++ N + +
Sbjct: 1040 ARLEATVAEINDELEKEKQQRHNAETARRAAETQLREEQESCLEKTRKAEELTNQLMRKE 1099
Query: 61 GELKEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQ-IKQRLA 119
EL ++ + A RQQ+ +I+ + AQ+ E N +K + + + + L
Sbjct: 1100 SELSQISIRNDEELAARQQLEREIREIRAQLDDAIEETNKEKAARQKAEKARRDMAEELE 1159
Query: 120 EIDDEI-ASGDLSLVEERLRVKEMQSLHKLSKDF--------QVVEPIR----KSIEEEK 166
E+ S D +++ +L+ K + L K +VVE ++ K IEE
Sbjct: 1160 SYKQELEESNDKTVLHSQLKAKRDEEYAHLQKQLEETVKSSEEVVEEMKAQNQKKIEELN 1219
Query: 167 EQIDALKKE-LNASNPKEVA-AKFETIQGQINNLNSKNQVVYDKRKTLIT-------KRS 217
E ID LK++ ++A K A + E + +++N+ S KRK T K
Sbjct: 1220 ETIDQLKRQKISADKAKSSAESDNENFRAELSNIASARLEAEKKRKAAETSLMEKDHKMR 1279
Query: 218 ALYNKRDEIYTQIRKIRGDFDN--EFKSFKKKLDEQRLKREE--DEKLSKILEDKEE 270
+ + D++ ++ K+ + ++ + KS + L+ LK+ D +LS++ E EE
Sbjct: 1280 EMQSNLDDLMAKLSKMNNELESIQKAKSADETLNSNLLKKNASLDMQLSELTEASEE 1336
>YKR095w [S] KOG4674 Uncharacterized conserved coiled-coil protein
Length = 1875
Score = 55.1 bits (131), Expect = 2e-07
Identities = 61/290 (21%), Positives = 139/290 (47%), Gaps = 24/290 (8%)
Query: 4 ARPKQHIQKPDVTVRDKKLEPLNVQLKKIDQELSL---IKQQIDNTDFSK--DAKNSKEK 58
+R Q + T + + LN ++ + +E+ I+QQ+ T ++ D N E
Sbjct: 1404 SRELQAKLEESTTSYESTINGLNEEITTLKEEIEKQRQIQQQLQATSANEQNDLSNIVES 1463
Query: 59 LQGELKEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRL 118
++ +E +K K Q+++++I ++ + S + + K + ++ ++ Q++
Sbjct: 1464 MKKSFEE--DKIKFIKEKTQEVNEKILEAQERLNQPSNINMEEIKKKWESEHEQEVSQKI 1521
Query: 119 AEIDDEIASGDLSLVEERLRVKEMQSLHKLSKDF-QVVEPIRKSIEEEKEQIDALKKELN 177
E ++ + EE++ + +L K+F + VE KS+E+ E L+K+L
Sbjct: 1522 REAEEALKKRIRLPTEEKINKIIERKKEELEKEFEEKVEERIKSMEQSGEIDVVLRKQLE 1581
Query: 178 ASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIR-KIRGD 236
A +V K + ++ N N+ + ++ K + ++RD++ +I ++R +
Sbjct: 1582 A----KVQEKQKELE------NEYNKKLQEELKDVPHSSHISDDERDKLRAEIESRLREE 1631
Query: 237 FDNEFKSFKKKLDEQRLKREEDEKLSKILEDKEEKVGKLQERLNHAKQPA 286
F+NE ++ KKK ++ K++ K + + E K+ K++ +L+ KQ A
Sbjct: 1632 FNNELQAIKKKSFDEG-KQQAMMKTTLL----ERKLAKMESQLSETKQSA 1676
Score = 52.4 bits (124), Expect = 1e-06
Identities = 64/300 (21%), Positives = 136/300 (45%), Gaps = 32/300 (10%)
Query: 3 TARPKQHIQKPDVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGE 62
T R ++ I VTV ++ + L ++ +D EL + ++DN+ K+ +S
Sbjct: 1149 TLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDARTKLDNSRVEKENHSS------- 1201
Query: 63 LKEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQN-VGQIKQRLAEI 121
+I+ D+ K Q++ ++ I ++ E+ + K K+ Q+ + ++KQ +A I
Sbjct: 1202 ---IIQQHDDIMEKLNQLN---LLRESNITLRN-ELENNNNKKKELQSELDKLKQNVAPI 1254
Query: 122 DDEIASGDLSLVEERLRVK-EMQSLHKLSKDFQVV----EPIRKSIEEEKE-QIDALKKE 175
+ E+ + S+ E+ +K + +H+ K Q + E + S E+ E +I+ LK+E
Sbjct: 1255 ESELTALKYSMQEKEQELKLAKEEVHRWKKRSQDILEKHEQLSSSDYEKLESEIENLKEE 1314
Query: 176 LNASNPK--EVAAKFETIQGQINNLNSKNQVVYD----KRKTLITKRSALYNKRDEIYTQ 229
L + E KF ++ Q +++ D + +L ++ L N E +
Sbjct: 1315 LENKERQGAEAEEKFNRLRRQAQERLKTSKLSQDSLTEQVNSLRDAKNVLENSLSEANAR 1374
Query: 230 IRKIR----GDFDNEFKSFKK-KLDEQRLKREEDEKLSKILEDKEEKVGKLQERLNHAKQ 284
I +++ +N+ ++ +K + D ++ RE KL + E + L E + K+
Sbjct: 1375 IEELQNAKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKE 1434
>Hs11321579 [Z] KOG0161 Myosin class II heavy chain
Length = 1938
Score = 55.1 bits (131), Expect = 2e-07
Identities = 68/317 (21%), Positives = 139/317 (43%), Gaps = 38/317 (11%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTD-FSKDAKNSKEKLQGELKEVIKTQSD 72
D+ V + K+ L K++Q+ ++ ++ D + +K KL+G+LK ++ D
Sbjct: 1013 DLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQ-NVGQIKQRLAEIDDEI-ASGDL 130
L+ ++QQI +++K + ++ + I+D + +FQ + +++ R+ E+++EI A L
Sbjct: 1073 LENEKQQIEEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132
Query: 131 SLVEERLRVKEMQSLHKLSKDFQVV------------------EPIRKSIEEEKEQIDAL 172
E+ R + L ++S+ + + +R+ +EE Q +A
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 173 KKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTL---ITKRSALYNKRDEIYTQ 229
L VA E QI+NL Q + ++ L I ++ + +
Sbjct: 1193 AATLRKKQADSVAELGE----QIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSN 1248
Query: 230 IRKIRGDFDNEFKSFKKKLDEQRLKREEDEKLSKI--------LEDKEEKVGKLQERLNH 281
I + +++F K K DEQ+ + D + K L + E+ L +L
Sbjct: 1249 IERTCRTVEDQFSEIKAK-DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307
Query: 282 AKQPAFTFELESIENML 298
+KQ A T +LE ++ +
Sbjct: 1308 SKQ-ALTQQLEELKRQM 1323
>CE04618 [Z] KOG0161 Myosin class II heavy chain
Length = 1956
Score = 55.1 bits (131), Expect = 2e-07
Identities = 69/337 (20%), Positives = 152/337 (44%), Gaps = 59/337 (17%)
Query: 21 KLEPLNVQLKKIDQELSLIKQQID----NTDFSKDAKNSKEKLQGELKEVIKTQSDLKAK 76
K+E LN QL K D+EL + D N + + EL+E ++T+ + + K
Sbjct: 1069 KVEELNNQLMKRDEELQHQLTRYDEESANVTLMQKQMRDMQTTIDELREDMETERNARNK 1128
Query: 77 RQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEER 136
+ ++ AQ+++ G++ D V + Q++ K DE + +E+
Sbjct: 1129 AEMTRREVV---AQLEKVKGDVLDKVDEATMLQDLMSRK-------DEEVNATKRAIEQI 1178
Query: 137 LRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPK--EVAAKFETIQGQ 194
E + + +K + VE + IE+ K+Q L+K+ N ++ + ++A + +Q
Sbjct: 1179 QHTMEGKIEEQKAKFSRQVEELHDQIEQHKKQRSQLEKQQNQADQERADMAQEIALLQAS 1238
Query: 195 INNLNSKNQV--------------VYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNE 240
+++ K ++ + ++TLI + L RDE+ + ++R + ++
Sbjct: 1239 RADIDKKRKIHEAHLMEIQANLAESDEHKRTLIDQ---LERSRDEL-DHLNRVREEEEHA 1294
Query: 241 FKSFKKKL---------------DEQRLK-------REEDEKLSKILEDKEEKVG---KL 275
F + +++L +E RLK R+ +++ + +L++KEE G L
Sbjct: 1295 FANMQRRLATAEGQIQELNEQIQEETRLKIANINRARQLEDEKNALLDEKEEAEGLRAHL 1354
Query: 276 QERLNHAKQPAFTFELESIENMLTVLDPTYVKPVKNV 312
++ ++ A+Q A ++ E++ L+ K +++V
Sbjct: 1355 EKEIHAARQGAGEARRKAEESVNQQLEELRKKNLRDV 1391
>Hs7661992 [KRT] KOG4572 Predicted DNA-binding transcription factor interacts
with stathmin
Length = 1591
Score = 54.7 bits (130), Expect = 3e-07
Identities = 74/364 (20%), Positives = 170/364 (46%), Gaps = 40/364 (10%)
Query: 9 HIQKPDVTVRDKKLEPLNVQLKKI----DQELSLIKQQIDNTDFSKDAKNSKEKLQ-GEL 63
H Q ++ + E + LKK+ D++L L++ ++ + + S K ++ LQ +
Sbjct: 942 HSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSH-LKELEDTLQVRHI 1000
Query: 64 KEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDD 123
+E K +D + +++ + + + QI+ EI + K K+ Q ++K +++++ D
Sbjct: 1001 QEFEKVMTDHRVSLEELKKENQQIINQIQESHAEI--IQEKEKQLQ---ELKLKVSDLSD 1055
Query: 124 EIASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKE----QIDALKKELNAS 179
++ L + E++ L + S+ Q E ++ +E+E E +I L +++ +
Sbjct: 1056 TRCKLEVELALKEAETDEIKILLEESRA-QQKETLKSLLEQETENLRTEISKLNQKIQDN 1114
Query: 180 NPKEVAAKFE-----TIQGQ--INNLNSKNQVVYDKRKTLITKRSALYNKRDEIYT---- 228
N E TI+ I+ L S+++ + K + K ++L+N+ EI
Sbjct: 1115 NENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKE 1174
Query: 229 QIRKIRGDFDNEFKSFKKKLDEQRLKREE---------DEKLSKILEDKEEKVGKLQERL 279
QI +++ D+E + +++ DE+ ++EE ++ K++ +E+ +L ++L
Sbjct: 1175 QIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKL 1234
Query: 280 NHAKQPAFTFELESIENMLTVLDPTYVKPVKNVLGIDFGSTSQQTATPTKTVDSEGLVPI 339
N K A L+ + V++ ++ VK++ ++ A + DS LV
Sbjct: 1235 NCEKDEAIQTALKEFKLEREVVEKELLEKVKHL----ENQIAKSPAIDSTRGDSSSLVAE 1290
Query: 340 VKER 343
++E+
Sbjct: 1291 LQEK 1294
>Hs5032287 [NTZ] KOG4286 Dystrophin-like protein
Length = 3681
Score = 54.7 bits (130), Expect = 3e-07
Identities = 64/275 (23%), Positives = 124/275 (44%), Gaps = 21/275 (7%)
Query: 37 SLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSG 96
SL +QQ S K +K E+ K QS+ ++I + K L +Q+
Sbjct: 984 SLQEQQSGLYYLSTTVKEMSKKAPSEISR--KYQSEF----EEIEGRWKKLSSQLVEHCQ 1037
Query: 97 EINDLVGKNKKFQN-VGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVV 155
++ + + K +K QN + +K+ +AE+D + +L + + K+++ L D Q +
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1097
Query: 156 EPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQIN-NLNSKNQVVYDKRKTL-- 212
+P S+ E ++I N + P E A++ ET ++N + Q VY +++ L
Sbjct: 1098 QPSLNSVNEGGQKIK------NEAEP-EFASRLETELKELNTQWDHMCQQVYARKEALKG 1150
Query: 213 -ITKRSALYNKRDEIYTQIRKIRGDF-DNEFKSFKKKLDEQRLKREEDEKLSKILEDKEE 270
+ K +L E++ + + ++ + +F+ K DE + EE ++ + + KE
Sbjct: 1151 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFE--YKTPDELQKAVEEMKRAKEEAQQKEA 1208
Query: 271 KVGKLQERLNHAKQPAFTFELESIENMLTVLDPTY 305
KV L E +N A E+++ L L Y
Sbjct: 1209 KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNY 1243
Score = 50.4 bits (119), Expect = 6e-06
Identities = 63/280 (22%), Positives = 118/280 (41%), Gaps = 38/280 (13%)
Query: 29 LKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGE--LKEVIKTQSDLKAKRQQIHDQIKF 86
++ DQ + I + I D D K+ Q E LK + +D++ K DQ
Sbjct: 1677 METFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 1736
Query: 87 LDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLH 146
L A + LV + ++ R A I I +G S+ ++ L
Sbjct: 1737 LMAN---RGDHCRKLVEPQ-----ISELNHRFAAISHRIKTGKASI--------PLKELE 1780
Query: 147 KLSKDFQ-VVEPIRKSIEE----EKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSK 201
+ + D Q ++EP+ I++ ++E + E N KE+ + + +Q +I + K
Sbjct: 1781 QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD-ERK 1839
Query: 202 NQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL 261
+ + K++ L TK +AL + R +Q RK + +++ +K++ D+ L
Sbjct: 1840 REEIKIKQQLLQTKHNALKDLR----SQRRKKALEISHQWYQYKRQADD----------L 1885
Query: 262 SKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVL 301
K L+D E+K+ L E + K EL+ + L +
Sbjct: 1886 LKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 1925
>Hs5032285 [NTZ] KOG4286 Dystrophin-like protein
Length = 3562
Score = 54.7 bits (130), Expect = 3e-07
Identities = 64/275 (23%), Positives = 124/275 (44%), Gaps = 21/275 (7%)
Query: 37 SLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSG 96
SL +QQ S K +K E+ K QS+ ++I + K L +Q+
Sbjct: 865 SLQEQQSGLYYLSTTVKEMSKKAPSEISR--KYQSEF----EEIEGRWKKLSSQLVEHCQ 918
Query: 97 EINDLVGKNKKFQN-VGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVV 155
++ + + K +K QN + +K+ +AE+D + +L + + K+++ L D Q +
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 978
Query: 156 EPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQIN-NLNSKNQVVYDKRKTL-- 212
+P S+ E ++I N + P E A++ ET ++N + Q VY +++ L
Sbjct: 979 QPSLNSVNEGGQKIK------NEAEP-EFASRLETELKELNTQWDHMCQQVYARKEALKG 1031
Query: 213 -ITKRSALYNKRDEIYTQIRKIRGDF-DNEFKSFKKKLDEQRLKREEDEKLSKILEDKEE 270
+ K +L E++ + + ++ + +F+ K DE + EE ++ + + KE
Sbjct: 1032 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFE--YKTPDELQKAVEEMKRAKEEAQQKEA 1089
Query: 271 KVGKLQERLNHAKQPAFTFELESIENMLTVLDPTY 305
KV L E +N A E+++ L L Y
Sbjct: 1090 KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNY 1124
Score = 50.4 bits (119), Expect = 6e-06
Identities = 63/280 (22%), Positives = 118/280 (41%), Gaps = 38/280 (13%)
Query: 29 LKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGE--LKEVIKTQSDLKAKRQQIHDQIKF 86
++ DQ + I + I D D K+ Q E LK + +D++ K DQ
Sbjct: 1558 METFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 1617
Query: 87 LDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLH 146
L A + LV + ++ R A I I +G S+ ++ L
Sbjct: 1618 LMAN---RGDHCRKLVEPQ-----ISELNHRFAAISHRIKTGKASI--------PLKELE 1661
Query: 147 KLSKDFQ-VVEPIRKSIEE----EKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSK 201
+ + D Q ++EP+ I++ ++E + E N KE+ + + +Q +I + K
Sbjct: 1662 QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD-ERK 1720
Query: 202 NQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL 261
+ + K++ L TK +AL + R +Q RK + +++ +K++ D+ L
Sbjct: 1721 REEIKIKQQLLQTKHNALKDLR----SQRRKKALEISHQWYQYKRQADD----------L 1766
Query: 262 SKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVL 301
K L+D E+K+ L E + K EL+ + L +
Sbjct: 1767 LKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 1806
>Hs5032283 [NTZ] KOG4286 Dystrophin-like protein
Length = 3685
Score = 54.7 bits (130), Expect = 3e-07
Identities = 64/275 (23%), Positives = 124/275 (44%), Gaps = 21/275 (7%)
Query: 37 SLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSG 96
SL +QQ S K +K E+ K QS+ ++I + K L +Q+
Sbjct: 988 SLQEQQSGLYYLSTTVKEMSKKAPSEISR--KYQSEF----EEIEGRWKKLSSQLVEHCQ 1041
Query: 97 EINDLVGKNKKFQN-VGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVV 155
++ + + K +K QN + +K+ +AE+D + +L + + K+++ L D Q +
Sbjct: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1101
Query: 156 EPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQIN-NLNSKNQVVYDKRKTL-- 212
+P S+ E ++I N + P E A++ ET ++N + Q VY +++ L
Sbjct: 1102 QPSLNSVNEGGQKIK------NEAEP-EFASRLETELKELNTQWDHMCQQVYARKEALKG 1154
Query: 213 -ITKRSALYNKRDEIYTQIRKIRGDF-DNEFKSFKKKLDEQRLKREEDEKLSKILEDKEE 270
+ K +L E++ + + ++ + +F+ K DE + EE ++ + + KE
Sbjct: 1155 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFE--YKTPDELQKAVEEMKRAKEEAQQKEA 1212
Query: 271 KVGKLQERLNHAKQPAFTFELESIENMLTVLDPTY 305
KV L E +N A E+++ L L Y
Sbjct: 1213 KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNY 1247
Score = 50.4 bits (119), Expect = 6e-06
Identities = 63/280 (22%), Positives = 118/280 (41%), Gaps = 38/280 (13%)
Query: 29 LKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGE--LKEVIKTQSDLKAKRQQIHDQIKF 86
++ DQ + I + I D D K+ Q E LK + +D++ K DQ
Sbjct: 1681 METFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 1740
Query: 87 LDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLH 146
L A + LV + ++ R A I I +G S+ ++ L
Sbjct: 1741 LMAN---RGDHCRKLVEPQ-----ISELNHRFAAISHRIKTGKASI--------PLKELE 1784
Query: 147 KLSKDFQ-VVEPIRKSIEE----EKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSK 201
+ + D Q ++EP+ I++ ++E + E N KE+ + + +Q +I + K
Sbjct: 1785 QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD-ERK 1843
Query: 202 NQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL 261
+ + K++ L TK +AL + R +Q RK + +++ +K++ D+ L
Sbjct: 1844 REEIKIKQQLLQTKHNALKDLR----SQRRKKALEISHQWYQYKRQADD----------L 1889
Query: 262 SKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVL 301
K L+D E+K+ L E + K EL+ + L +
Sbjct: 1890 LKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 1929
>Hs5032281 [NTZ] KOG4286 Dystrophin-like protein
Length = 3677
Score = 54.7 bits (130), Expect = 3e-07
Identities = 64/275 (23%), Positives = 124/275 (44%), Gaps = 21/275 (7%)
Query: 37 SLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSG 96
SL +QQ S K +K E+ K QS+ ++I + K L +Q+
Sbjct: 980 SLQEQQSGLYYLSTTVKEMSKKAPSEISR--KYQSEF----EEIEGRWKKLSSQLVEHCQ 1033
Query: 97 EINDLVGKNKKFQN-VGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVV 155
++ + + K +K QN + +K+ +AE+D + +L + + K+++ L D Q +
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1093
Query: 156 EPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQIN-NLNSKNQVVYDKRKTL-- 212
+P S+ E ++I N + P E A++ ET ++N + Q VY +++ L
Sbjct: 1094 QPSLNSVNEGGQKIK------NEAEP-EFASRLETELKELNTQWDHMCQQVYARKEALKG 1146
Query: 213 -ITKRSALYNKRDEIYTQIRKIRGDF-DNEFKSFKKKLDEQRLKREEDEKLSKILEDKEE 270
+ K +L E++ + + ++ + +F+ K DE + EE ++ + + KE
Sbjct: 1147 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFE--YKTPDELQKAVEEMKRAKEEAQQKEA 1204
Query: 271 KVGKLQERLNHAKQPAFTFELESIENMLTVLDPTY 305
KV L E +N A E+++ L L Y
Sbjct: 1205 KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNY 1239
Score = 50.4 bits (119), Expect = 6e-06
Identities = 63/280 (22%), Positives = 118/280 (41%), Gaps = 38/280 (13%)
Query: 29 LKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGE--LKEVIKTQSDLKAKRQQIHDQIKF 86
++ DQ + I + I D D K+ Q E LK + +D++ K DQ
Sbjct: 1673 METFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 1732
Query: 87 LDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLH 146
L A + LV + ++ R A I I +G S+ ++ L
Sbjct: 1733 LMAN---RGDHCRKLVEPQ-----ISELNHRFAAISHRIKTGKASI--------PLKELE 1776
Query: 147 KLSKDFQ-VVEPIRKSIEE----EKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSK 201
+ + D Q ++EP+ I++ ++E + E N KE+ + + +Q +I + K
Sbjct: 1777 QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD-ERK 1835
Query: 202 NQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL 261
+ + K++ L TK +AL + R +Q RK + +++ +K++ D+ L
Sbjct: 1836 REEIKIKQQLLQTKHNALKDLR----SQRRKKALEISHQWYQYKRQADD----------L 1881
Query: 262 SKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVL 301
K L+D E+K+ L E + K EL+ + L +
Sbjct: 1882 LKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 1921
>Hs14735371 [S] KOG4725 Uncharacterized conserved protein
Length = 834
Score = 54.7 bits (130), Expect = 3e-07
Identities = 57/294 (19%), Positives = 128/294 (43%), Gaps = 21/294 (7%)
Query: 31 KIDQELSLIKQQIDNTDFSKDAKNSKE-KLQGELKEVIKTQSDLKAKRQQIHDQIKFLDA 89
K+ +EL+ Q+ + A KE +LQ +L E +K L+ + ++ ++ L
Sbjct: 255 KVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQE 314
Query: 90 QIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIAS--GDLSLVEERLRVKEMQSLHK 147
++ + K++K QN Q++ ++ +++E+ + +E+ L ++ +S +
Sbjct: 315 TSEQAQSKF-----KSEK-QNRKQLELKVTSLEEELTDLRVEKESLEKNLSERKKKSAQE 368
Query: 148 LSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQINN---------L 198
S+ + ++ IRKS +EE +++ L K+ S + A + +Q ++ L
Sbjct: 369 RSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLL 428
Query: 199 NSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKREED 258
S + + + +R A K ++ + ++ K ++ + E + +
Sbjct: 429 ASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQM 488
Query: 259 EKLSKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVLDPTYVKPVKNV 312
+ D EKV K+ ++ + + FELE N T+L T + +K V
Sbjct: 489 SGVEAAASDPSEKVKKIMNQVFQSLRR--EFELEESYNGRTILG-TIMNTIKMV 539
>Hs5453642 [D] KOG0018 Structural maintenance of chromosome protein 1 (sister
chromatid cohesion complex Cohesin subunit SMC1)
Length = 1233
Score = 54.3 bits (129), Expect = 4e-07
Identities = 68/287 (23%), Positives = 131/287 (44%), Gaps = 57/287 (19%)
Query: 5 RPKQHIQKPDVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELK 64
R K + + V ++ KL V+++K+++EL+ ++I+ KD K +K++ ELK
Sbjct: 211 RLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIE-----KDKKRM-DKVEDELK 264
Query: 65 EVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGE-INDLVGKNKKFQNVGQIKQRL--AEI 121
E K + ++QQI +IK D+++ +K + I + K + + K+ L A+
Sbjct: 265 EKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQK 324
Query: 122 DDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNP 181
+ GD+ +E KEM S+ K ++F+ + +EEE +
Sbjct: 325 HYKKRKGDMDELE-----KEMLSVEKARQEFE------ERMEEESQS------------- 360
Query: 182 KEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEF 241
QG+ L Y + K +KR+A + E F+ +
Sbjct: 361 ----------QGRDLTLEENQVKKYHRLKEEASKRAATLAQELE----------KFNRDQ 400
Query: 242 KSFKKKLD-EQRLKREEDEKLSKIL---EDKEEKVGKLQERLNHAKQ 284
K+ + +LD E+R K E + K+ + L E+ ++++ KL+E + +KQ
Sbjct: 401 KADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQ 447
>Hs20542063 [Z] KOG0161 Myosin class II heavy chain
Length = 1939
Score = 54.3 bits (129), Expect = 4e-07
Identities = 65/310 (20%), Positives = 143/310 (45%), Gaps = 46/310 (14%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSK-DAKNSKEKLQGELKEVIKTQSD 72
D+ V + K+ L+ K++Q++ ++ ++ + D + +K KL+G+LK ++ D
Sbjct: 1011 DLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1070
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEIND-----LVGKNKKFQNVGQIKQRLAEIDDEIA- 126
L+ + Q+ +++K + I +++ +I D L + K +N +I++ E++ E
Sbjct: 1071 LENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTA 1130
Query: 127 -----------SGDLSLVEERLRVK------EMQSLHKLSKDFQVVEPIRKSIEEEKEQI 169
S +L + ERL +++ K +FQ +R+ +EE Q
Sbjct: 1131 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ---KMRRDLEEATLQH 1187
Query: 170 DALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIY-- 227
+A L + VA E QI+NL Q + ++ + + + ++I
Sbjct: 1188 EATAAALRKKHADSVAELGE----QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA 1243
Query: 228 -TQIRKIRGDFDNEFKSFKKKLDE----------QRLK-REEDEKLSKILEDKEEKVGKL 275
+ K+ +++ ++ KL+E QR K + E+ +L++ LE+KE + +L
Sbjct: 1244 KANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQL 1303
Query: 276 -QERLNHAKQ 284
+ +L++ +Q
Sbjct: 1304 TRGKLSYTQQ 1313
>Hs14764231 [D] KOG0018 Structural maintenance of chromosome protein 1 (sister
chromatid cohesion complex Cohesin subunit SMC1)
Length = 1233
Score = 54.3 bits (129), Expect = 4e-07
Identities = 68/287 (23%), Positives = 131/287 (44%), Gaps = 57/287 (19%)
Query: 5 RPKQHIQKPDVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELK 64
R K + + V ++ KL V+++K+++EL+ ++I+ KD K +K++ ELK
Sbjct: 211 RLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIE-----KDKKRM-DKVEDELK 264
Query: 65 EVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGE-INDLVGKNKKFQNVGQIKQRL--AEI 121
E K + ++QQI +IK D+++ +K + I + K + + K+ L A+
Sbjct: 265 EKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQK 324
Query: 122 DDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNP 181
+ GD+ +E KEM S+ K ++F+ + +EEE +
Sbjct: 325 HYKKRKGDMDELE-----KEMLSVEKARQEFE------ERMEEESQS------------- 360
Query: 182 KEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEF 241
QG+ L Y + K +KR+A + E F+ +
Sbjct: 361 ----------QGRDLTLEENQVKKYHRLKEEASKRAATLAQELE----------KFNRDQ 400
Query: 242 KSFKKKLD-EQRLKREEDEKLSKIL---EDKEEKVGKLQERLNHAKQ 284
K+ + +LD E+R K E + K+ + L E+ ++++ KL+E + +KQ
Sbjct: 401 KADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQ 447
>SPBC146.03c [BD] KOG0996 Structural maintenance of chromosome protein 4
(chromosome condensation complex Condensin subunit C)
Length = 1324
Score = 53.9 bits (128), Expect = 5e-07
Identities = 62/288 (21%), Positives = 124/288 (42%), Gaps = 20/288 (6%)
Query: 18 RDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKR 77
R+KK N+ L ++ +L ++ + T+ KN + K E +K + K
Sbjct: 369 RNKKTLVQNL-LNSLEGKLQAHLEKFEQTERDISEKNEEVKSLREKAAKVKNDCTSEKKT 427
Query: 78 QQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQ-NVGQIKQRLAEIDDEIASGDLSLVEER 136
+Q ++Q Q + ++ L+ K KK + ++ + +E ++ ++S D+ +
Sbjct: 428 RQSYEQ------QTVKIEEQLKFLLNKEKKLKKSIEALSFEKSEAENSLSSHDIDSQKLN 481
Query: 137 LRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQIN 196
+ ++ +L ++ ++ IRKS++ + E I +E K +A E +IN
Sbjct: 482 SEIADLSL--RLQQEELSLDDIRKSLQGKTEGISNAIEE----KQKAMAPALE----KIN 531
Query: 197 NLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKRE 256
L S+ Q++ + L+ K + L N + + + K+R D + KL +
Sbjct: 532 QLTSEKQILQVELDMLLNKENDLINDVESSQSSLDKLRNDAEENRNILSSKLKVLSDLKG 591
Query: 257 EDEKLSKILEDKEEKVGKLQERL--NHAKQPAFTFELESIENMLTVLD 302
E + +SK +E K+E V L N K L S + VL+
Sbjct: 592 EKKDVSKNIERKKETVHNTYRNLMSNRTKLEEMKASLSSSRSRGNVLE 639
>Hs17978507 [Z] KOG0161 Myosin class II heavy chain
Length = 1581
Score = 53.9 bits (128), Expect = 5e-07
Identities = 64/332 (19%), Positives = 141/332 (42%), Gaps = 20/332 (6%)
Query: 20 KKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAK-----NSKEKLQGELKEVIKTQSDLK 74
K+L L ++K ++EL +Q + AK + Q KE+ +++
Sbjct: 1084 KQLRDLEAKVKDQEEELD---EQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVE 1140
Query: 75 AKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVE 134
RQ ++K ++ Q++ + + K K + +++ +LA + D++ D E
Sbjct: 1141 EARQSCQKKLKQMEVQLEEEYED------KQKVLREKRELEGKLATLSDQVNRRDFES-E 1193
Query: 135 ERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAA--KFETIQ 192
+RLR K+++ L D Q++ K+ K +I LK +L S AA + ++
Sbjct: 1194 KRLR-KDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAME 1252
Query: 193 GQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQR 252
+I +L+ + + + L + S L +++EI ++ + + D + K K + +
Sbjct: 1253 VEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQAS 1312
Query: 253 LKREEDEKLSKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVLDPTYVKPVKNV 312
+ L LE+ ++ +LQE+L + E ++ L ++ ++
Sbjct: 1313 RDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETR 1372
Query: 313 LGIDFGSTSQQTATPTKTVDSEGLVPIVKERE 344
L +F T + + E + + +ER+
Sbjct: 1373 L--EFERTQVKRLESLASRLKENMEKLTEERD 1402
>7298332 [BD] KOG0996 Structural maintenance of chromosome protein 4
(chromosome condensation complex Condensin subunit C)
Length = 1409
Score = 53.5 bits (127), Expect = 7e-07
Identities = 49/251 (19%), Positives = 115/251 (45%), Gaps = 21/251 (8%)
Query: 17 VRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAK 76
+ K LE + +Q +++ ++ ++Q + + ++ + K LQ + E + + +
Sbjct: 785 ISQKALEDMQIQAEELQARVNYCQEQQGSLE--REIQTLKNGLQRDEAEYKRLAVSITSL 842
Query: 77 RQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRL--AEIDDEIASGDLSLVE 134
QQ+ +K +AQ +R + D ++ + + KQ L A+ ++ S
Sbjct: 843 EQQMASNLKQCEAQRQRMLKKTTDERAVKEREEQIEAAKQELEQAQFAEQAVSS------ 896
Query: 135 ERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAA--KFETIQ 192
+++E+Q+ + ++ + V+P+ I++ QI+ L + + N A I
Sbjct: 897 ---QIEEIQNQYDTLRN-ESVKPVEAKIKKVNSQIEKLAANVRSLNVGLATADRNITKIT 952
Query: 193 GQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFD---NEFKSFKKKLD 249
G NNL + +K K+L R+ K++E+ +I + + ++ KK++D
Sbjct: 953 GNNNNLRENIKAAEEKLKSLNEDRNKAKEKKEELEKEIEESEASIEGAKSQSSDIKKEID 1012
Query: 250 EQRLKREEDEK 260
E + +EE+++
Sbjct: 1013 E--ITKEENKR 1021
>Hs14149661 [U] KOG4809 Rab6 GTPase-interacting protein involved in
endosome-to-TGN transport
Length = 948
Score = 53.1 bits (126), Expect = 9e-07
Identities = 57/276 (20%), Positives = 130/276 (46%), Gaps = 28/276 (10%)
Query: 15 VTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELK--EVIKTQSD 72
+ ++D K+ + L+ +++E+ ++K + S E+ + E+K EV ++ S
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKS---------NGALSTEEREEEMKQMEVYRSHSK 434
Query: 73 -LKAKRQQIHDQIKFLDAQIKRKSGEINDLVGK-NKKFQNVGQIKQRLAEIDDEIASGDL 130
+K K Q+ ++ D ++ ++ L + + Q++ +K+ L + A
Sbjct: 435 FMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQT 494
Query: 131 SLVEERLRVKEMQS-LHKLSKDFQVVEPIRKS----IEEEKEQIDALKKELNASNPKEVA 185
+ RLR++E ++ L+K +K Q + + + I + K+ +D ++++N +
Sbjct: 495 EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV-----LQ 549
Query: 186 AKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFK 245
K E +Q Q+ + + + ++ K+L A D T + + + + + K
Sbjct: 550 KKIENLQEQLRDKEKQMSSLKERVKSL----QADTTNTDTALTTLEEALAEKERTIERLK 605
Query: 246 KKLD-EQRLKREEDEKLSKILEDKEEKVGKLQERLN 280
++ D ++R K+EE + K L+D +EKV LQ L+
Sbjct: 606 EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS 641
Score = 50.8 bits (120), Expect = 4e-06
Identities = 68/306 (22%), Positives = 126/306 (40%), Gaps = 46/306 (15%)
Query: 1 MSTARPKQHIQKPDVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTD---------FSKD 51
MS+ + + + D T D L L L + ++ + +K+Q D + + KD
Sbjct: 566 MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 625
Query: 52 AKNSKEK---LQGELKEVIKTQSDLKAKRQQI-------HDQIKFLDAQIKRKSGEINDL 101
K+ KEK LQG+L E + DLK + ++K L+ +++K E +
Sbjct: 626 LKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM 685
Query: 102 VGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKS 161
+ KK + E+ D I L E R K+ S K + + I K
Sbjct: 686 ESQLKKAHEAALEARASPEMSDRIQ----HLEREITRYKDESS--KAQAEVDRLLEILKE 739
Query: 162 IEEEKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKR----- 216
+E EK D EL + ++V + ++ NL K QV K ++ +
Sbjct: 740 VENEKNDKDKKIAELESLTSRQVKDQ----NKKVANLKHKEQVEKKKSAQMLEEARRRED 795
Query: 217 ----SALYNKRDEIYTQIRKIRGDFDN---EFKSFKKKLDEQ-----RLKREEDEKLSKI 264
S+ + +E+ + K++ + ++ + S ++ L E+ L+ E + L ++
Sbjct: 796 NLNDSSQQLQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 855
Query: 265 LEDKEE 270
LE K+E
Sbjct: 856 LEMKQE 861
>CE21149 [L] KOG0962 DNA repair protein RAD50 ABC-type ATPase/SMC
superfamily
Length = 1298
Score = 53.1 bits (126), Expect = 9e-07
Identities = 72/311 (23%), Positives = 136/311 (43%), Gaps = 50/311 (16%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDF---SKDAKNSKEKLQGELKEVIKTQ 70
DV + +KLE + Q +K ++ L+ + ++ F S +A+ EKL+ K + K +
Sbjct: 581 DVQLNVQKLETMQHQYRKQEESLTAQELKLSENIFEACSCEAEEVSEKLENLRKRLKKAR 640
Query: 71 SDLK--AKRQQIHDQI----------KFLDAQIKRKSGEINDLVGKNKKFQNVGQI---- 114
DL + + ++D D K K EIN+ +KK +N+
Sbjct: 641 KDLAPLSAKSNLYDSYIEESKSSGCCPLCDRDFKTKK-EINEF---SKKLENMTLSFPTE 696
Query: 115 KQRLAEIDDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRK---SIEEEKEQIDA 171
++ L ++ ++ ++ +V+ + E+Q + K K+ V E RK + EEK +
Sbjct: 697 QEELEKLVSKLEKEEIIIVKAEGQANELQRIVKELKE--VREKNRKLSTEMAEEKSNLSK 754
Query: 172 LKKELNASNPK-EVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQI 230
+K+L N K ++A +T G I L + + + + L+++ + YT++
Sbjct: 755 NEKQLETVNAKLKLAEDLQTDVGVIQQLYEQTEENEKRYEQLVSESDSSDGLS---YTEL 811
Query: 231 RKIRGDFDNEFKSFKKKLDEQRLKREEDEKLSKILEDKEEKVGKLQERLNH--------A 282
RK D D E++ +E E+L K E++ + KL E H A
Sbjct: 812 RKKVEDKDEEYRKIV----------QEGEELQKCSEERNKLQSKLNELGTHRVSLGEAAA 861
Query: 283 KQPAFTFELES 293
+ AF +LE+
Sbjct: 862 QAGAFAEQLET 872
>SPCC162.08c [S] KOG4674 Uncharacterized conserved coiled-coil protein
Length = 1837
Score = 52.4 bits (124), Expect = 1e-06
Identities = 68/285 (23%), Positives = 134/285 (46%), Gaps = 47/285 (16%)
Query: 12 KPDVTVRDKKLEPLNVQLKKIDQELSLIKQQI----------DNTDFSKDAKNSKEKLQG 61
K ++T+ D + LN Q+K + + ++ ++ D TD + + + +L
Sbjct: 1216 KYELTILDNR--GLNQQVKSLQSTVDSLQLELNRLQSLPVSNDQTDTPIISGSQEVQLLY 1273
Query: 62 ELKEVIKTQSDLK-AKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAE 120
E V++ +D K K Q++ +++ L+A + EIN+L AE
Sbjct: 1274 ESNSVLRKDNDAKLGKIQELEKEVEKLNASLNPLQTEINELK----------------AE 1317
Query: 121 IDDEIASGDLSLVEE---RLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELN 177
I + AS L+L++E R +++ L+K ++ V+P + +EE K+ +AL+KE
Sbjct: 1318 IGAKTAS--LNLMKEYNSRWKLRFQSVLNK----YERVDPTQ--LEELKKNCEALEKEKQ 1369
Query: 178 ASNPK--EVAAKFETIQGQINNLNSKNQVV---YDKRKTLITKRSALYNKRDEIYTQIRK 232
K E A + +T + Q+N+LN + + + ++ T T+ +A +N++ E +
Sbjct: 1370 ELETKLQETAKETDTFKQQVNSLNEEVENLKKEVEQANTKNTRLAAAWNEKCENLKKSSL 1429
Query: 233 IRGDFDNEFKSFKKKLDEQRLKREEDEKLSKILEDKEEKVGKLQE 277
R F + + K E K E+E + K +E ++ +LQE
Sbjct: 1430 TR--FAHLKQELTNKNKELTSKNAENEAMQKEIESLKDSNHQLQE 1472
>Hs4505301 [Z] KOG0161 Myosin class II heavy chain
Length = 1937
Score = 52.4 bits (124), Expect = 1e-06
Identities = 56/276 (20%), Positives = 120/276 (43%), Gaps = 43/276 (15%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTD-FSKDAKNSKEKLQGELKEVIKTQSD 72
D+ + K+ L K++Q++ ++ ++ D + +K KL+G+LK ++ D
Sbjct: 1012 DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMD 1071
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVG-QIKQRLAEIDDEIAS-GDL 130
++ +QQ LD ++++K EI++L+ K + Q V Q+++++ E+ I G+
Sbjct: 1072 MENDKQQ-------LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEE 1124
Query: 131 SLVEERLRVKEMQSLHKLSKDFQVV-------------------------EPIRKSIEEE 165
E R K + LS++ + + + +R+ +EE
Sbjct: 1125 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEA 1184
Query: 166 KEQIDALKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDE 225
Q +A+ L + +A E QI+NL Q + ++ L + L + +
Sbjct: 1185 TLQHEAMVAALRKKHADSMAELGE----QIDNLQRVKQKLEKEKSELKMETDDLSSNAE- 1239
Query: 226 IYTQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL 261
I K +G + +S + ++ + K EE ++L
Sbjct: 1240 ---AISKAKGHLEKMCRSLEDQVSGLKTKEEEQQRL 1272
>YJL074c [D] KOG0964 Structural maintenance of chromosome protein 3 (sister
chromatid cohesion complex Cohesin subunit SMC3)
Length = 1230
Score = 51.6 bits (122), Expect = 2e-06
Identities = 57/281 (20%), Positives = 124/281 (43%), Gaps = 21/281 (7%)
Query: 16 TVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKA 75
T+ D++L + Q++++D + + + + ++ ++ + K++ ++ LK
Sbjct: 233 TLYDRELNEVINQMERLDGDYN--NTVYSSEQYIQELDKREDMIDQVSKKLSSIEASLKI 290
Query: 76 KRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEE 135
K Q K +++I +K +N K K Q + + +D S++E+
Sbjct: 291 KNATDLQQAKLRESEISQKLTNVNV---KIKDVQQQIESNEEQRNLDSATLKEIKSIIEQ 347
Query: 136 RLRV--KEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKE-----VAAKF 188
R + K + +L+K+ + + S+++++ + K E K+ + ++
Sbjct: 348 RKQKLSKILPRYQELTKEEAMYKLQLASLQQKQRDLILKKGEYARFKSKDERDTWIHSEI 407
Query: 189 ETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIR--KIRG---DFDNEFKS 243
E ++ I NLN + R +L + SA+ + +E+ I +G DFD+E
Sbjct: 408 EELKSSIQNLNELESQLQMDRTSLRKQYSAIDEEIEELIDSINGPDTKGQLEDFDSELIH 467
Query: 244 FKKKLDEQRLKREE----DEKLSKILEDKEEKVGKLQERLN 280
K+KL E R+E ++KL +LE V + Q +N
Sbjct: 468 LKQKLSESLDTRKELWRKEQKLQTVLETLLSDVNQNQRNVN 508
>Hs22045440 [T] KOG0612 Rho-associated coiled-coil containing protein kinase
Length = 636
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/304 (20%), Positives = 129/304 (42%), Gaps = 46/304 (15%)
Query: 26 NVQLKKIDQELSLIKQQIDNTDFSK----DAKNSKEKLQGELKEVIKTQSDLKAKRQQIH 81
++++K + +E+ +++Q+ + + +A +++L +++ + +K +Q+
Sbjct: 98 DLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQERE 157
Query: 82 DQIKFL---DAQIKRKSGEINDLVGKNK-KFQNVGQIKQRLAEIDDEIASGDLSLVEERL 137
D K L ++K +S E+ D + K Q +I +RL E+ + + +
Sbjct: 158 DLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQK-----LARHV 212
Query: 138 RVKE------MQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETI 191
R KE MQ + L ++ + E +K +E E + A AS +++ + E
Sbjct: 213 RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAA-----EASKDRKLREQSEHY 267
Query: 192 QGQINN----------------LNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRG 235
Q+ N + ++Q K KT + K+S Y + ++ K G
Sbjct: 268 SKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEE------ELSKREG 321
Query: 236 DFDNEFKSFKKKLDEQRLKREEDEKLSKILEDKEEKVGKLQERLNHAKQPAFTFELESIE 295
NE K+ KK+L + ++ K IL+DK EK + + + F + E +
Sbjct: 322 IHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREK 381
Query: 296 NMLT 299
+LT
Sbjct: 382 VLLT 385
>Hs14772793 [Z] KOG0161 Myosin class II heavy chain
Length = 1220
Score = 51.6 bits (122), Expect = 2e-06
Identities = 51/277 (18%), Positives = 131/277 (46%), Gaps = 18/277 (6%)
Query: 14 DVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTD-FSKDAKNSKEKLQGELKEVIKTQSD 72
D+ + ++ L +++Q++ ++ ++ D + +K KL+G+LK ++ +D
Sbjct: 714 DLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVAD 773
Query: 73 LKAKRQQIHDQIKFLDAQIKRKSGEIND--LVGKNKKFQNVGQIKQRLAEIDDEIASGDL 130
+QQ+ +++K D+++ + S + D L+G + + + +++ R E+++E+ +
Sbjct: 774 AAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQ-KKIKELQARAEELEEELEAERA 832
Query: 131 SLVE-ERLRVKEMQSLHKLSKDFQVVEPI----RKSIEEEKEQIDALKKELNAS---NPK 182
+ E+ R + + L +LS+ + R+ + + ++ L++EL + +
Sbjct: 833 ARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEA 892
Query: 183 EVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIR---KIRGDFDN 239
VAA L + + R+ L ++S L + D++ + + + +
Sbjct: 893 TVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEK 952
Query: 240 EFKSFKKKLDEQRLKREEDEKLSKILEDKEEKVGKLQ 276
++++ +L E ++K EE L + L D + G+LQ
Sbjct: 953 LCRTYEDQLSEAKIKVEE---LQRQLADASTQRGRLQ 986
>7292701_2 [S] KOG4415 Uncharacterized conserved protein
Length = 1643
Score = 51.6 bits (122), Expect = 2e-06
Identities = 64/324 (19%), Positives = 155/324 (47%), Gaps = 23/324 (7%)
Query: 1 MSTARPKQHIQKPDVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKL- 59
M+ + K+ ++ ++ +++K+ E +Q K+ +++L L K++ ++ ++ K +EK+
Sbjct: 717 MTIDKEKEKAKEKELKLKEKEREA-KLQEKEKEEKLKL-KEREESLRMEREEKLKEEKIK 774
Query: 60 QGELKEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLA 119
+ E +E +K + K K +Q +++K + K + + + + K + + K R
Sbjct: 775 EKEREEKLKEE---KIKEKQREEKLKEEKLKEKEREERMKEKEREEKAKEKQREEKLREE 831
Query: 120 EIDDEIASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNAS 179
+I ++ L ++KE + KL K+ R+ EKE+ + +K++
Sbjct: 832 KIKEKEREEKLKEKLREEKIKEKEKEEKLRKE-------REEKMREKEREEKIKEKERVE 884
Query: 180 NPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNK--RDEIYTQIRKIRGDF 237
KE + + + + L K +++ K K + L K ++++ + R+ +
Sbjct: 885 KIKEKEREEKLKKEKEEKLKEKEELLKKKEKEEKEREEKLKEKERQEKLKEKEREEKLKR 944
Query: 238 DNEFKSFKKKLDEQRLKREEDEKLSKI-----LEDKEEKVGKLQE--RLNHAKQPAFTFE 290
+ E + +K+ +E+ ++E EKL + L++KEE++ + ++ +L K+ E
Sbjct: 945 ETEERQREKEREEKLKEKERAEKLKDLEKEVKLKEKEEQLKEKEKELKLKEKKEKDKVKE 1004
Query: 291 LE-SIENMLTVLDPTYVKPVKNVL 313
E S+E+ ++ T P + V+
Sbjct: 1005 KEKSLESEKLLISATVSNPWRRVV 1028
>CE27954 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 3484
Score = 51.2 bits (121), Expect = 3e-06
Identities = 98/450 (21%), Positives = 179/450 (39%), Gaps = 84/450 (18%)
Query: 7 KQHIQKPDVTVRDKK--LEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELK 64
K+ +K D ++ K L+P + K D K+ + D +K A +SK + +
Sbjct: 664 KKKTEKSDSSISQKSNVLKPADDDKSKSDDVTDKSKKTTE--DQTKVATDSKLEKAADTT 721
Query: 65 EVIKTQS--DLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNK-------KFQNVGQIK 115
+ I+T++ D K+K++ + + + D+ I +KS E +V K K V + K
Sbjct: 722 KQIETETVVDDKSKKKVLKKKTEKSDSFISQKS-ETPPVVEPTKPAESEAQKIAEVNKAK 780
Query: 116 QRLAEIDD----EIASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDA 171
++ E+DD E + +E+L+++ ++ K ++ VE +K +KE+ +
Sbjct: 781 KQ-KEVDDNLKREAEVAAKKIADEKLKIEAEANIKKTAE----VEAAKK----QKEKDEQ 831
Query: 172 LKKELNASNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIR 231
LK E + K A K E L + Q+ + K+ L K
Sbjct: 832 LKLETEVVSKKSAAEKLE--------LEKQAQIKKAAEADAVKKQKELNEK--------- 874
Query: 232 KIRGDFDNEFKSFKKKL-DEQRLKREEDEKLSKILEDK----EEKVGKLQERLNHAKQPA 286
N+ ++ KK D+ +L+ E K K+ E+ EEK K E+
Sbjct: 875 -------NKLEAAKKSAADKLKLEEESAAKSKKVSEESVKFGEEKKTKAGEK-------- 919
Query: 287 FTFELESIENMLTVLDPTYVKPVKNVLGIDFGSTSQQTATPTKTVDSEGLVPIVKEREGX 346
T ++ES +PT K + D G+T TP K I+K++
Sbjct: 920 -TVQVES--------EPTSKKTIDTK---DVGATEPADETPKKK--------IIKKKTEK 959
Query: 347 XXXXXXXXXXXXXXXXXXXXXXLEPSMIALLAELDIRVPLSKGDVPATVEQLKAKHEDLT 406
EP+ A+ + T E+LK E
Sbjct: 960 SDSSISQKSATDSEKVSKQKEQDEPTKPAVSETQMVTEADKSKKQKETDEKLKLDAEIAA 1019
Query: 407 AKQPEATEKNIAEAEEQLKKLNLEYEAKEQ 436
+ EA EK+ +A+E++KK++ + A+++
Sbjct: 1020 KTKQEADEKSKLDAQEKIKKVSEDDAARKE 1049
>Hs4503613 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and related
proteins
Length = 2033
Score = 50.8 bits (120), Expect = 4e-06
Identities = 50/269 (18%), Positives = 123/269 (45%), Gaps = 32/269 (11%)
Query: 21 KLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKRQQI 80
+L+ + L++ E ++ Q++ T + +L G L E + +R+Q+
Sbjct: 1353 ELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEV-------GRRRQL 1405
Query: 81 HDQIKFLDAQIKRKSGEINDLVGKNKKF---QNVGQIKQRLAEIDDEIASGDLSLVEERL 137
+++ L A ++ + G ++ ++KK + + Q+ R+ E++ + V+E++
Sbjct: 1406 ELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPT-----VQEKI 1460
Query: 138 RVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPKEVAAKFETIQGQINN 197
++E+ L K + E +R +++EK Q+ L +E K + + + +Q
Sbjct: 1461 IMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNREC-----KNLQVQIDVLQ----K 1511
Query: 198 LNSKNQVVYDKRKTLITKRSALYNKRDEIYTQI---RKIRGDFDNEFKSFKKKLDEQ--- 251
S+ + +Y K + K L ++R ++ + R R + E + ++++D
Sbjct: 1512 AKSQEKTIY-KEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETL 1570
Query: 252 -RLKREEDEKLSKILEDKEEKVGKLQERL 279
R E+ +L + + +++ G+LQ+ L
Sbjct: 1571 GRTWSREESELQRARDQADQECGRLQQEL 1599
>Hs13124879 [Z] KOG0161 Myosin class II heavy chain
Length = 1972
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/269 (22%), Positives = 122/269 (45%), Gaps = 22/269 (8%)
Query: 23 EPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLK-------A 75
E + V+L QEL I +++ ++ ++ ++LQ E K++ + DL+ A
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEAR--LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 76 KRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEE 135
RQ++ + +A+IK+ EI + +N K ++ +++ I+ +L EE
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL------LEERISDLTTNLAEE 1018
Query: 136 RLRVKEMQSL-HKLSKDFQVVEPIRKSIEEEKEQIDALKKEL--NASNPKE----VAAKF 188
+ K + L +K +E K E+ +++++ LK++L +AS+ E + A+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 189 ETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKL 248
++ Q+ + Q + I +++ K E+ I ++ D D+E + K
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 249 DEQRLKREEDEKLSKILEDKEEKVGKLQE 277
++R EE E L LED + QE
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQE 1167
>Hs13124877 [Z] KOG0161 Myosin class II heavy chain
Length = 1266
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/269 (22%), Positives = 122/269 (45%), Gaps = 22/269 (8%)
Query: 23 EPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLK-------A 75
E + V+L QEL I +++ ++ ++ ++LQ E K++ + DL+ A
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEAR--LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 76 KRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEE 135
RQ++ + +A+IK+ EI + +N K ++ +++ I+ +L EE
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL------LEERISDLTTNLAEE 1018
Query: 136 RLRVKEMQSL-HKLSKDFQVVEPIRKSIEEEKEQIDALKKEL--NASNPKE----VAAKF 188
+ K + L +K +E K E+ +++++ LK++L +AS+ E + A+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 189 ETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKL 248
++ Q+ + Q + I +++ K E+ I ++ D D+E + K
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 249 DEQRLKREEDEKLSKILEDKEEKVGKLQE 277
++R EE E L LED + QE
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQE 1167
>Hs13124875 [Z] KOG0161 Myosin class II heavy chain
Length = 1938
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/269 (22%), Positives = 122/269 (45%), Gaps = 22/269 (8%)
Query: 23 EPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLK-------A 75
E + V+L QEL I +++ ++ ++ ++LQ E K++ + DL+ A
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEAR--LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 76 KRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEE 135
RQ++ + +A+IK+ EI + +N K ++ +++ I+ +L EE
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL------LEERISDLTTNLAEE 1018
Query: 136 RLRVKEMQSL-HKLSKDFQVVEPIRKSIEEEKEQIDALKKEL--NASNPKE----VAAKF 188
+ K + L +K +E K E+ +++++ LK++L +AS+ E + A+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 189 ETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKL 248
++ Q+ + Q + I +++ K E+ I ++ D D+E + K
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 249 DEQRLKREEDEKLSKILEDKEEKVGKLQE 277
++R EE E L LED + QE
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQE 1167
>Hs5032291 [NTZ] KOG4286 Dystrophin-like protein
Length = 2341
Score = 50.4 bits (119), Expect = 6e-06
Identities = 63/280 (22%), Positives = 118/280 (41%), Gaps = 38/280 (13%)
Query: 29 LKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGE--LKEVIKTQSDLKAKRQQIHDQIKF 86
++ DQ + I + I D D K+ Q E LK + +D++ K DQ
Sbjct: 337 METFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 396
Query: 87 LDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLH 146
L A + LV + ++ R A I I +G S+ ++ L
Sbjct: 397 LMAN---RGDHCRKLVEPQ-----ISELNHRFAAISHRIKTGKASI--------PLKELE 440
Query: 147 KLSKDFQ-VVEPIRKSIEE----EKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSK 201
+ + D Q ++EP+ I++ ++E + E N KE+ + + +Q +I + K
Sbjct: 441 QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD-ERK 499
Query: 202 NQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL 261
+ + K++ L TK +AL + R +Q RK + +++ +K++ D+ L
Sbjct: 500 REEIKIKQQLLQTKHNALKDLR----SQRRKKALEISHQWYQYKRQADD----------L 545
Query: 262 SKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVL 301
K L+D E+K+ L E + K EL+ + L +
Sbjct: 546 LKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 585
>Hs5032289 [NTZ] KOG4286 Dystrophin-like protein
Length = 2344
Score = 50.4 bits (119), Expect = 6e-06
Identities = 63/280 (22%), Positives = 118/280 (41%), Gaps = 38/280 (13%)
Query: 29 LKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGE--LKEVIKTQSDLKAKRQQIHDQIKF 86
++ DQ + I + I D D K+ Q E LK + +D++ K DQ
Sbjct: 340 METFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 399
Query: 87 LDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDLSLVEERLRVKEMQSLH 146
L A + LV + ++ R A I I +G S+ ++ L
Sbjct: 400 LMAN---RGDHCRKLVEPQ-----ISELNHRFAAISHRIKTGKASI--------PLKELE 443
Query: 147 KLSKDFQ-VVEPIRKSIEE----EKEQIDALKKELNASNPKEVAAKFETIQGQINNLNSK 201
+ + D Q ++EP+ I++ ++E + E N KE+ + + +Q +I + K
Sbjct: 444 QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD-ERK 502
Query: 202 NQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKL 261
+ + K++ L TK +AL + R +Q RK + +++ +K++ D+ L
Sbjct: 503 REEIKIKQQLLQTKHNALKDLR----SQRRKKALEISHQWYQYKRQADD----------L 548
Query: 262 SKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVL 301
K L+D E+K+ L E + K EL+ + L +
Sbjct: 549 LKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 588
>CE24961 [DY] KOG0977 Nuclear envelope protein lamin intermediate filament
superfamily
Length = 592
Score = 50.4 bits (119), Expect = 6e-06
Identities = 71/298 (23%), Positives = 131/298 (43%), Gaps = 29/298 (9%)
Query: 21 KLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEKLQGELKEVIKTQSDLKAKR--- 77
K++ L V L ++ E+SL+K++I + K K++ Q L E+ + ++DL +
Sbjct: 188 KIDALLVTLSNLEAEISLLKRRI--AQLEDEVKRIKQENQRLLSELQRARTDLDQETLNR 245
Query: 78 -------QQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEIASGDL 130
Q + ++I FL + E+ L ++ +N K L+ +I +
Sbjct: 246 IDYQNQVQTLLEEIDFLRRVHDNEIKELQTLASRDTTPENREFFKNELSSAIRDIRE-EY 304
Query: 131 SLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEE--EKEQIDALKKELNASNPK--EVAA 186
V R +M+S ++L + R+++E+ KE++ L+ +L+ K ++ +
Sbjct: 305 DQVNNVHR-NDMESWYRLKVQEIQTQSARQNMEQGYAKEEVKRLRTQLSDLRGKLADLES 363
Query: 187 KFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFDNEFKSFKK 246
+ ++ QI LN Q+ D+R A N RD +QIRK+R + +
Sbjct: 364 RNSLLEKQIQELNY--QLEDDQRSY-----EAALNDRD---SQIRKMREECQALMVELQM 413
Query: 247 KLDEQRLKREEDEKLSKILEDKEEKVGKLQERLNHAKQPAFTFELESIENMLTVLDPT 304
LD ++ E K+LE +E + G Q K A T E ++ E M V T
Sbjct: 414 LLDTKQTLDAEIAIYRKMLEGEENRAGLKQLVEQVVKTHAITQETDT-ETMRVVKGET 470
>CE15746 [DY] KOG0977 Nuclear envelope protein lamin intermediate filament
superfamily
Length = 566
Score = 50.4 bits (119), Expect = 6e-06
Identities = 61/290 (21%), Positives = 128/290 (44%), Gaps = 31/290 (10%)
Query: 7 KQHIQKPDVTVRDKKLEPLNVQLKKIDQELSLIKQQIDNTDFSKDAKNSKEK-LQGELKE 65
K I+ V KKL+P Q++K+++EL+ ++Q + D +K+K LQ +
Sbjct: 115 KYRIEYDAAKVEVKKLKP---QVEKLERELAGAEEQALHAQSIADQSQAKQKTLQARNDK 171
Query: 66 VIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDDEI 125
++ DLK + + D ++ L ++ ++ + NK + +++ LA +
Sbjct: 172 LVVENDDLKKQNITLRDTVEGLKKAVEDET--LLRTAANNK----IKALEEDLAFALQQ- 224
Query: 126 ASGDLSLVEERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQI------------DALK 173
G+L V + +V +++ ++Q ++ IEE + Q DA K
Sbjct: 225 HKGELEEVRHKRQVDMTTYAKQINDEYQ--SKLQDQIEEMRAQFKNNLHQNKTAFEDAYK 282
Query: 174 KELNASNPKEVAAKFETI--QGQINNLNSKNQ----VVYDKRKTLITKRSALYNKRDEIY 227
+LNA+ ++ A E I + ++ +L + + ++ R L T + + K D+
Sbjct: 283 NKLNAARERQEEAVSEAIHLRARVRDLETSSSGNASLIERLRSELDTLKRSFQEKLDDKD 342
Query: 228 TQIRKIRGDFDNEFKSFKKKLDEQRLKREEDEKLSKILEDKEEKVGKLQE 277
+I ++ + + F LD + E + +LE +EE++ QE
Sbjct: 343 ARIAELNQEIERMMSEFHDLLDVKIQLDAELKTYQALLEGEEERLNLTQE 392
>Hs4505993 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and related
proteins
Length = 1756
Score = 50.1 bits (118), Expect = 7e-06
Identities = 66/301 (21%), Positives = 132/301 (42%), Gaps = 36/301 (11%)
Query: 28 QLKKIDQELSLIKQQIDNTD-------FSKDAKNSKE--KLQGELKEVIKTQSDLKAKRQ 78
QLKK Q L K Q+ + F +D + +E L+ +L E K Q DL+ +R
Sbjct: 1271 QLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERA 1330
Query: 79 QIHDQIKFLDAQIKR-KSGEINDLVGKNKKFQNVGQIKQRLAE-IDDEIASGDLSLVE-- 134
+QI + ++ R K + V + ++ + AE ID E+ D E
Sbjct: 1331 SQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELR 1390
Query: 135 --ERLRVKEMQSLHKLSKDFQVVEPIRKSIEEEKEQIDALKKELNASNPK---------- 182
+R R + + L +L ++ Q + ++ ++++ AL++E + K
Sbjct: 1391 RLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQ 1450
Query: 183 ---EVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSAL----YNKRDEIYTQIRKIRG 235
+ A + ++ Q+ + Q++ + +TL K +AL ++ + ++ +G
Sbjct: 1451 QDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKG 1510
Query: 236 DFDNEFKSFKKKLDEQ-RLKREEDEKLSKI---LEDKEEKVGKLQERLNHAKQPAFTFEL 291
D + E + K L+E+ R KRE D ++S++ L + E K + L+ ++ +L
Sbjct: 1511 DTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQL 1570
Query: 292 E 292
E
Sbjct: 1571 E 1571
>7301097 [D] KOG0018 Structural maintenance of chromosome protein 1 (sister
chromatid cohesion complex Cohesin subunit SMC1)
Length = 1238
Score = 49.7 bits (117), Expect = 9e-06
Identities = 48/233 (20%), Positives = 105/233 (44%), Gaps = 21/233 (9%)
Query: 64 KEVIKTQSDLKAKRQQIHDQIKFLDAQIKRKSGEINDLVGKNKKFQNVGQIKQRLAEIDD 123
+++ K SDL+ ++Q++ ++++ ++++ + KK + G+I + LA+ID
Sbjct: 256 RDIRKFTSDLEVRQQEVK--------AVEQRKEAADEILREKKK--DAGKITRDLAKIDQ 305
Query: 124 EIASGDLSLVEER-LRVKEMQSLHKLSKDF----QVVEPIRKSIEEEKEQIDALKKELNA 178
EI + + + R L +K + + K + +E R++ + I L+K+L
Sbjct: 306 EIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQL-- 363
Query: 179 SNPKEVAAKFETIQGQINNLNSKNQVVYDKRKTLITKRSALYNKRDEIYTQIRKIRGDFD 238
+V A + + +I N + + + + L+ + L + + TQ R +
Sbjct: 364 ---ADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVN 420
Query: 239 NEFKSFKKKLDEQRLKREE-DEKLSKILEDKEEKVGKLQERLNHAKQPAFTFE 290
E KS + LD + +R +E K+ +EE V + + ++H K E
Sbjct: 421 REQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALE 473
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.309 0.129 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,410,341
Number of Sequences: 60738
Number of extensions: 1020823
Number of successful extensions: 8130
Number of sequences better than 1.0e-05: 55
Number of HSP's better than 0.0 without gapping: 0
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 7740
Number of HSP's gapped (non-prelim): 292
length of query: 467
length of database: 30,389,216
effective HSP length: 110
effective length of query: 357
effective length of database: 23,708,036
effective search space: 8463768852
effective search space used: 8463768852
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)