ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0426 check: MH T KOG0032 Signal transduction mechanisms Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0426 144356 145771 472
(472 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJL057c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 298 2e-80
At1g62400 [T] KOG0192 Tyrosine kinase specific for activated (GT... 91 4e-18
At3g63260 [T] KOG0192 Tyrosine kinase specific for activated (GT... 84 6e-16
At5g58950 [T] KOG0192 Tyrosine kinase specific for activated (GT... 81 3e-15
7290150 [T] KOG0583 Serine/threonine protein kinase 81 3e-15
At3g01490 [T] KOG0192 Tyrosine kinase specific for activated (GT... 81 4e-15
At3g20860 [R] KOG0589 Serine/threonine protein kinase 80 5e-15
At5g50000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 80 9e-15
Hs4506103 [J] KOG1033 eIF-2alpha kinase PEK/EIF2AK3 78 3e-14
At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 78 3e-14
CE26649 [D] KOG0575 Polo-like serine/threonine protein kinase 77 7e-14
At4g14780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 76 1e-13
SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase 75 2e-13
At3g22750 [T] KOG0192 Tyrosine kinase specific for activated (GT... 75 2e-13
7293761 [T] KOG4721 Serine/threonine protein kinase contains leu... 74 4e-13
Hs5453970 [T] KOG0694 Serine/threonine protein kinase 74 5e-13
Hs4504101 [T] KOG0986 G protein-coupled receptor kinase 74 5e-13
Hs14735945 [T] KOG0694 Serine/threonine protein kinase 73 8e-13
Hs19923134 [T] KOG4250 TANK binding protein kinase TBK1 73 1e-12
At1g67890 [T] KOG0192 Tyrosine kinase specific for activated (GT... 73 1e-12
Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains l... 72 1e-12
CE07285 [D] KOG0575 Polo-like serine/threonine protein kinase 72 2e-12
Hs4758128_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 72 2e-12
HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase 72 2e-12
CE22877 [D] KOG0575 Polo-like serine/threonine protein kinase 72 2e-12
At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GT... 72 2e-12
At2g35050_2 [T] KOG0192 Tyrosine kinase specific for activated (... 72 2e-12
CE18366 [T] KOG0583 Serine/threonine protein kinase 71 3e-12
At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 71 3e-12
7295638 [T] KOG0603 Ribosomal protein S6 kinase 71 3e-12
7290313 [T] KOG0193 Serine/threonine protein kinase RAF 71 3e-12
Hs4505195 [T] KOG0192 Tyrosine kinase specific for activated (GT... 71 4e-12
At4g31170 [T] KOG0192 Tyrosine kinase specific for activated (GT... 71 4e-12
Hs14749517 [T] KOG0192 Tyrosine kinase specific for activated (G... 70 5e-12
At3g46930 [T] KOG0192 Tyrosine kinase specific for activated (GT... 70 5e-12
At1g79570_2 [T] KOG0192 Tyrosine kinase specific for activated (... 70 5e-12
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 70 7e-12
Hs20536136 [T] KOG0192 Tyrosine kinase specific for activated (G... 70 7e-12
CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 70 7e-12
At5g01850 [T] KOG0192 Tyrosine kinase specific for activated (GT... 70 7e-12
At2g31010 [T] KOG0192 Tyrosine kinase specific for activated (GT... 70 7e-12
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 70 7e-12
YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase 70 9e-12
Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase 70 9e-12
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 70 9e-12
CE01554 [T] KOG0986 G protein-coupled receptor kinase 70 9e-12
YDL101c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 69 1e-11
HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains ... 69 1e-11
Hs4757868 [T] KOG0193 Serine/threonine protein kinase RAF 69 1e-11
Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains ... 69 1e-11
Hs20538863 [T] KOG4250 TANK binding protein kinase TBK1 69 1e-11
Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase 69 1e-11
At5g50180 [T] KOG0192 Tyrosine kinase specific for activated (GT... 69 1e-11
At3g24720 [T] KOG0192 Tyrosine kinase specific for activated (GT... 69 1e-11
At1g54510 [R] KOG0589 Serine/threonine protein kinase 69 1e-11
At1g16270_2 [T] KOG0192 Tyrosine kinase specific for activated (... 69 1e-11
YCL024w [T] KOG0583 Serine/threonine protein kinase 69 2e-11
SPAC890.03 [T] KOG0583 Serine/threonine protein kinase 69 2e-11
Hs5453964 [T] KOG0583 Serine/threonine protein kinase 69 2e-11
CE28819 [T] KOG1095 Protein tyrosine kinase 69 2e-11
SPCC63.08c [OUT] KOG0595 Serine/threonine-protein kinase involve... 69 2e-11
Hs5453976 [T] KOG0694 Serine/threonine protein kinase 69 2e-11
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 69 2e-11
At1g04700_2 [T] KOG0192 Tyrosine kinase specific for activated (... 69 2e-11
YDR122w [T] KOG0583 Serine/threonine protein kinase 68 3e-11
Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PK... 68 3e-11
At4g38470 [T] KOG0192 Tyrosine kinase specific for activated (GT... 68 3e-11
7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 68 3e-11
Hs4826684_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 68 3e-11
Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 68 3e-11
Hs14916455 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 68 3e-11
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 68 3e-11
CE17354 [T] KOG0694 Serine/threonine protein kinase 68 3e-11
CE17353 [T] KOG0694 Serine/threonine protein kinase 68 3e-11
At3g04810 [R] KOG0589 Serine/threonine protein kinase 68 3e-11
SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase 67 4e-11
HsM4758892 [J] KOG1033 eIF-2alpha kinase PEK/EIF2AK3 67 4e-11
Hs7705748 [T] KOG0192 Tyrosine kinase specific for activated (GT... 67 4e-11
Hs4506401 [T] KOG0193 Serine/threonine protein kinase RAF 67 4e-11
Hs21361155 [J] KOG1033 eIF-2alpha kinase PEK/EIF2AK3 67 4e-11
Hs14776113 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 67 4e-11
At5g55560 [R] KOG0584 Serine/threonine protein kinase 67 4e-11
At3g11870 [T] KOG1027 Serine/threonine protein kinase and endori... 67 4e-11
At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GT... 67 4e-11
7290147 [T] KOG0583 Serine/threonine protein kinase 67 4e-11
YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 67 6e-11
YDR507c [D] KOG0588 Serine/threonine protein kinase 67 6e-11
HsM4507279 [D] KOG0580 Serine/threonine protein kinase 67 6e-11
Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 67 6e-11
CE23001 [R] KOG0589 Serine/threonine protein kinase 67 6e-11
At5g28290 [R] KOG0589 Serine/threonine protein kinase 67 6e-11
Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved... 67 8e-11
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 67 8e-11
At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 67 8e-11
At1g08720 [T] KOG0192 Tyrosine kinase specific for activated (GT... 67 8e-11
YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 66 1e-10
Hs14150045 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 66 1e-10
At5g11015 [T] KOG1187 Serine/threonine protein kinase 66 1e-10
7299793 [T] KOG0583 Serine/threonine protein kinase 66 1e-10
At3g46920_2 [T] KOG0192 Tyrosine kinase specific for activated (... 66 1e-10
YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 66 1e-10
YLR096w [T] KOG0583 Serine/threonine protein kinase 66 1e-10
CE12518 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 66 1e-10
7292679 [G] KOG0599 Phosphorylase kinase gamma subunit 66 1e-10
At5g57610_2 [T] KOG0192 Tyrosine kinase specific for activated (... 66 1e-10
YDR466w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 65 2e-10
Hs7661974 [T] KOG0583 Serine/threonine protein kinase 65 2e-10
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 65 2e-10
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 65 2e-10
Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 65 2e-10
Hs20545357 [T] KOG0583 Serine/threonine protein kinase 65 2e-10
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 65 2e-10
CE27768 [R] KOG0586 Serine/threonine protein kinase 65 2e-10
CE23838 [R] KOG0586 Serine/threonine protein kinase 65 2e-10
7302048 [J] KOG1035 eIF-2alpha kinase GCN2 65 2e-10
YKL048c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 65 3e-10
Hs4507275 [D] KOG0580 Serine/threonine protein kinase 65 3e-10
Hs22043888 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 65 3e-10
CE17343 [T] KOG0583 Serine/threonine protein kinase 65 3e-10
CE15235 [R] KOG0589 Serine/threonine protein kinase 65 3e-10
At5g56790 [T] KOG1187 Serine/threonine protein kinase 65 3e-10
At5g39440 [T] KOG0583 Serine/threonine protein kinase 65 3e-10
At3g58640 [T] KOG0192 Tyrosine kinase specific for activated (GT... 65 3e-10
7302050 [T] KOG0986 G protein-coupled receptor kinase 65 3e-10
YKL101w [D] KOG0588 Serine/threonine protein kinase 64 4e-10
SPBC4C3.11 [T] KOG0592 3-phosphoinositide-dependent protein kina... 64 4e-10
Hs20547878 [R] KOG0589 Serine/threonine protein kinase 64 4e-10
ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase 64 4e-10
At5g49470 [T] KOG0192 Tyrosine kinase specific for activated (GT... 64 4e-10
HsM4505263 [T] KOG0192 Tyrosine kinase specific for activated (G... 64 5e-10
Hs21735550 [T] KOG0192 Tyrosine kinase specific for activated (G... 64 5e-10
Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 64 5e-10
CE28643 [T] KOG0583 Serine/threonine protein kinase 64 5e-10
CE17284 [T] KOG0583 Serine/threonine protein kinase 64 5e-10
CE07458 [T] KOG0583 Serine/threonine protein kinase 64 5e-10
At5g12180 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 64 5e-10
At5g02070 [T] KOG1187 Serine/threonine protein kinase 64 5e-10
At3g27560 [T] KOG0192 Tyrosine kinase specific for activated (GT... 64 5e-10
YPL150w [T] KOG0583 Serine/threonine protein kinase 64 6e-10
SPBC557.04 [T] KOG1989 ARK protein kinase family 64 6e-10
Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 64 6e-10
Hs4758192 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 64 6e-10
Hs4506529 [T] KOG0986 G protein-coupled receptor kinase 64 6e-10
CE25585 [T] KOG0193 Serine/threonine protein kinase RAF 64 6e-10
CE18454 [T] KOG4717 Serine/threonine protein kinase 64 6e-10
CE09248 [T] KOG0200 Fibroblast/platelet-derived growth factor re... 64 6e-10
At4g31110 [T] KOG1187 Serine/threonine protein kinase 64 6e-10
At3g12200 [R] KOG0589 Serine/threonine protein kinase 64 6e-10
At3g06630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 64 6e-10
At3g06620 [T] KOG0192 Tyrosine kinase specific for activated (GT... 64 6e-10
7294217 [D] KOG0588 Serine/threonine protein kinase 64 6e-10
CE23702 [T] KOG4721 Serine/threonine protein kinase contains leu... 63 8e-10
CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 63 8e-10
At5g19360 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 63 8e-10
At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GT... 63 8e-10
At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 63 8e-10
At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 63 8e-10
7300551 [T] KOG1027 Serine/threonine protein kinase and endoribo... 63 8e-10
7293666 [D] KOG0575 Polo-like serine/threonine protein kinase 63 8e-10
CE27131_1 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase E... 63 8e-10
Hs4502435 [T] KOG0197 Tyrosine kinases 63 1e-09
CE28650 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 63 1e-09
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 63 1e-09
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 63 1e-09
CE11430 [T] KOG0194 Protein tyrosine kinase 63 1e-09
At4g23240 [T] KOG1187 Serine/threonine protein kinase 63 1e-09
At3g10660 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 63 1e-09
At3g06640 [T] KOG0192 Tyrosine kinase specific for activated (GT... 63 1e-09
At1g18390 [T] KOG1187 Serine/threonine protein kinase 63 1e-09
At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 63 1e-09
7304358 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 63 1e-09
7301213 [R] KOG0589 Serine/threonine protein kinase 63 1e-09
SPACUNK12.02c [T] KOG0032 Ca2+/calmodulin-dependent protein kina... 62 1e-09
Hs14768528 [T] KOG1187 Serine/threonine protein kinase 62 1e-09
CE24761 [D] KOG0580 Serine/threonine protein kinase 62 1e-09
CE01519 [T] KOG1027 Serine/threonine protein kinase and endoribo... 62 1e-09
At4g11890 [T] KOG1187 Serine/threonine protein kinase 62 1e-09
7294076 [T] KOG4278 Protein tyrosine kinase 62 1e-09
YDR523c [T] KOG0201 Serine/threonine protein kinase 62 2e-09
SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (... 62 2e-09
Hs5453966 [T] KOG0583 Serine/threonine protein kinase 62 2e-09
Hs4759178 [D] KOG0580 Serine/threonine protein kinase 62 2e-09
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 62 2e-09
Hs14042966 [T] KOG0583 Serine/threonine protein kinase 62 2e-09
ECU11g1500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 62 2e-09
CE28061 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE28060 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE28059 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE28058 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE28057 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE28056 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE28055 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE28054 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE28053 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE28051 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 62 2e-09
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 62 2e-09
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 62 2e-09
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 62 2e-09
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 62 2e-09
CE05507 [T] KOG0603 Ribosomal protein S6 kinase 62 2e-09
At5g60550 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase k... 62 2e-09
At5g38210 [T] KOG1187 Serine/threonine protein kinase 62 2e-09
At1g66880 [T] KOG1187 Serine/threonine protein kinase 62 2e-09
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 62 2e-09
Hs6005922_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 62 2e-09
Hs20127418 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase ... 62 2e-09
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 62 2e-09
CE02586 [T] KOG0696 Serine/threonine protein kinase 62 2e-09
At5g35410 [T] KOG0583 Serine/threonine protein kinase 62 2e-09
At4g33430 [T] KOG1187 Serine/threonine protein kinase 62 2e-09
At1g68690 [T] KOG1187 Serine/threonine protein kinase 62 2e-09
At1g55200 [T] KOG1187 Serine/threonine protein kinase 62 2e-09
YLR248w [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 61 3e-09
YGL158w [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 61 3e-09
Hs4505055 [T] KOG0197 Tyrosine kinases 61 3e-09
Hs4502193 [T] KOG0193 Serine/threonine protein kinase RAF 61 3e-09
Hs22046122 [OUT] KOG0595 Serine/threonine-protein kinase involve... 61 3e-09
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 61 3e-09
Hs18594815 [T] KOG0193 Serine/threonine protein kinase RAF 61 3e-09
Hs17933758 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 61 3e-09
CE09689 [T] KOG0194 Protein tyrosine kinase 61 3e-09
At1g73660 [T] KOG0192 Tyrosine kinase specific for activated (GT... 61 3e-09
YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase 61 4e-09
YJL187c [D] KOG0601 Cyclin-dependent kinase WEE1 61 4e-09
YGL180w [OUT] KOG0595 Serine/threonine-protein kinase involved i... 61 4e-09
YDR490c [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 61 4e-09
Hs8923539 [R] KOG0597 Serine-threonine protein kinase FUSED 61 4e-09
Hs20127541 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 61 4e-09
Hs14993776 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 61 4e-09
CE28494 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 61 4e-09
CE21025 [D] KOG0580 Serine/threonine protein kinase 61 4e-09
CE00747 [T] KOG0200 Fibroblast/platelet-derived growth factor re... 61 4e-09
At5g66210 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 61 4e-09
At5g47070 [T] KOG1187 Serine/threonine protein kinase 61 4e-09
At5g01820 [T] KOG0583 Serine/threonine protein kinase 61 4e-09
At4g04700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 61 4e-09
At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 61 4e-09
At1g70460 [T] KOG1187 Serine/threonine protein kinase 61 4e-09
At1g25390 [T] KOG1187 Serine/threonine protein kinase 61 4e-09
At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GT... 61 4e-09
At1g10620 [T] KOG1187 Serine/threonine protein kinase 61 4e-09
YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 60 5e-09
YGL179c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 60 5e-09
SPBC12D12.04c [T] KOG0694 Serine/threonine protein kinase 60 5e-09
Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 60 5e-09
Hs21361133 [R] KOG0586 Serine/threonine protein kinase 60 5e-09
Hs21166359 [T] KOG0986 G protein-coupled receptor kinase 60 5e-09
Hs14670383 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 60 5e-09
CE17429 [T] KOG0194 Protein tyrosine kinase 60 5e-09
At5g40540 [T] KOG0192 Tyrosine kinase specific for activated (GT... 60 5e-09
At5g38560 [T] KOG1187 Serine/threonine protein kinase 60 5e-09
At3g59350 [T] KOG1187 Serine/threonine protein kinase 60 5e-09
At3g25490 [T] KOG1187 Serine/threonine protein kinase 60 5e-09
7299437 [R] KOG0586 Serine/threonine protein kinase 60 5e-09
7296128 [T] KOG0583 Serine/threonine protein kinase 60 5e-09
YOL100w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 60 7e-09
YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 60 7e-09
SPAC57A10.02 [D] KOG0588 Serine/threonine protein kinase 60 7e-09
Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase 60 7e-09
Hs4505695 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 60 7e-09
Hs21361643 [T] KOG4717 Serine/threonine protein kinase 60 7e-09
CE20142 [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 60 7e-09
CE02074 [T] KOG0986 G protein-coupled receptor kinase 60 7e-09
At5g54590 [T] KOG1187 Serine/threonine protein kinase 60 7e-09
At5g42120 [T] KOG1187 Serine/threonine protein kinase 60 7e-09
At5g02800 [T] KOG1187 Serine/threonine protein kinase 60 7e-09
At2g28250 [T] KOG1187 Serine/threonine protein kinase 60 7e-09
7298323 [D] KOG0590 Checkpoint kinase and related serine/threoni... 60 7e-09
7296749 [J] KOG1033 eIF-2alpha kinase PEK/EIF2AK3 60 7e-09
YBR028c [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 60 9e-09
At4g23650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 60 9e-09
At2g26980 [T] KOG0583 Serine/threonine protein kinase 60 9e-09
7302860 [T] KOG0696 Serine/threonine protein kinase 60 9e-09
Hs20070247_2 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 60 9e-09
YFR014c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 59 1e-08
Hs4885347 [T] KOG0986 G protein-coupled receptor kinase 59 1e-08
Hs4885235 [T] KOG0197 Tyrosine kinases 59 1e-08
Hs22042851 [T] KOG0986 G protein-coupled receptor kinase 59 1e-08
CE29331 [T] KOG0194 Protein tyrosine kinase 59 1e-08
CE28218 [D] KOG0588 Serine/threonine protein kinase 59 1e-08
CE05274 [T] KOG0690 Serine/threonine protein kinase 59 1e-08
At4g24400 [T] KOG0583 Serine/threonine protein kinase 59 1e-08
At4g04710 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 59 1e-08
At4g00960 [T] KOG1187 Serine/threonine protein kinase 59 1e-08
At2g43230 [T] KOG1187 Serine/threonine protein kinase 59 1e-08
At2g42630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 59 1e-08
At1g48210 [T] KOG1187 Serine/threonine protein kinase 59 1e-08
At1g26970 [T] KOG1187 Serine/threonine protein kinase 59 1e-08
At1g12680 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 59 1e-08
7302570 [R] KOG0586 Serine/threonine protein kinase 59 1e-08
7297080 [T] KOG0583 Serine/threonine protein kinase 59 1e-08
7292592 [T] KOG1095 Protein tyrosine kinase 59 1e-08
7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 59 1e-08
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 59 1e-08
CE27894_1 [R] KOG0589 Serine/threonine protein kinase 59 1e-08
YNR047w [R] KOG0610 Putative serine/threonine protein kinase 59 2e-08
SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 59 2e-08
Hs7706286 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase E... 59 2e-08
Hs4885349 [T] KOG0986 G protein-coupled receptor kinase 59 2e-08
Hs4557377 [T] KOG0197 Tyrosine kinases 59 2e-08
Hs4507429 [T] KOG0197 Tyrosine kinases 59 2e-08
Hs14777335 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 59 2e-08
CE23883 [T] KOG4278 Protein tyrosine kinase 59 2e-08
CE21080 [T] KOG4278 Protein tyrosine kinase 59 2e-08
CE20167 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 59 2e-08
CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 59 2e-08
CE03506 [T] KOG4278 Protein tyrosine kinase 59 2e-08
At5g58380 [T] KOG0583 Serine/threonine protein kinase 59 2e-08
At5g10930 [T] KOG0583 Serine/threonine protein kinase 59 2e-08
At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 59 2e-08
At3g20530 [T] KOG1187 Serine/threonine protein kinase 59 2e-08
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 59 2e-08
Hs7662462 [T] KOG1989 ARK protein kinase family 59 2e-08
Hs4885609 [T] KOG0197 Tyrosine kinases 59 2e-08
Hs4502803 [D] KOG0590 Checkpoint kinase and related serine/threo... 59 2e-08
Hs22057171 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 59 2e-08
Hs14589904 [T] KOG0604 MAP kinase-activated protein kinase 2 59 2e-08
Hs10863901 [T] KOG0604 MAP kinase-activated protein kinase 2 59 2e-08
ECU03g0980 [T] KOG0583 Serine/threonine protein kinase 59 2e-08
CE27297 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 59 2e-08
At5g66790 [T] KOG1187 Serine/threonine protein kinase 59 2e-08
At5g04870 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 59 2e-08
At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 59 2e-08
At2g11520 [T] KOG1187 Serine/threonine protein kinase 59 2e-08
7304283 [Z] KOG0613 Projectin/twitchin and related proteins 59 2e-08
7299322 [R] KOG0611 Predicted serine/threonine protein kinase 59 2e-08
CE18058_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 59 2e-08
SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein ... 58 3e-08
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 58 3e-08
Hs4507273 [D] KOG0580 Serine/threonine protein kinase 58 3e-08
Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 58 3e-08
Hs14770402 [R] KOG0586 Serine/threonine protein kinase 58 3e-08
Hs14141724 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase ... 58 3e-08
CE27723 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 58 3e-08
CE26155 [T] KOG0194 Protein tyrosine kinase 58 3e-08
CE12472 [T] KOG0200 Fibroblast/platelet-derived growth factor re... 58 3e-08
At5g18500 [T] KOG1187 Serine/threonine protein kinase 58 3e-08
At5g15730 [T] KOG1187 Serine/threonine protein kinase 58 3e-08
At3g09830 [T] KOG1187 Serine/threonine protein kinase 58 3e-08
At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved... 58 3e-08
At2g20300 [T] KOG1187 Serine/threonine protein kinase 58 3e-08
At1g64300 [T] KOG0192 Tyrosine kinase specific for activated (GT... 58 3e-08
At1g56720 [T] KOG1187 Serine/threonine protein kinase 58 3e-08
At1g35670 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 58 3e-08
At1g26150 [T] KOG1187 Serine/threonine protein kinase 58 3e-08
At1g16670 [T] KOG1187 Serine/threonine protein kinase 58 3e-08
Hs4502567_1 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase... 58 3e-08
YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 58 4e-08
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 58 4e-08
Hs4885055 [T] KOG0986 G protein-coupled receptor kinase 58 4e-08
Hs4506067 [T] KOG0696 Serine/threonine protein kinase 58 4e-08
Hs15718680 [T] KOG0197 Tyrosine kinases 58 4e-08
Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase 58 4e-08
CE28251 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 58 4e-08
At5g24360 [T] KOG1027 Serine/threonine protein kinase and endori... 58 4e-08
At4g17660 [T] KOG1187 Serine/threonine protein kinase 58 4e-08
At3g24400 [T] KOG1187 Serine/threonine protein kinase 58 4e-08
At3g23000 [T] KOG0583 Serine/threonine protein kinase 58 4e-08
At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 58 4e-08
7302861 [T] KOG0696 Serine/threonine protein kinase 58 4e-08
7299480 [T] KOG0197 Tyrosine kinases 58 4e-08
7290903 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 58 4e-08
YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase 57 5e-08
YBR059c [T] KOG1989 ARK protein kinase family 57 5e-08
SPAC167.01 [T] KOG1027 Serine/threonine protein kinase and endor... 57 5e-08
HsM5454174 [T] KOG0201 Serine/threonine protein kinase 57 5e-08
Hs6005850 [D] KOG0615 Serine/threonine protein kinase Chk2 and r... 57 5e-08
Hs4758194 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 57 5e-08
Hs4501971 [T] KOG0986 G protein-coupled receptor kinase 57 5e-08
Hs21361358 [T] KOG0201 Serine/threonine protein kinase 57 5e-08
ECU08g1790 [D] KOG0600 Cdc2-related protein kinase 57 5e-08
CE27166 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 57 5e-08
CE24994 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 57 5e-08
CE06563 [T] KOG0194 Protein tyrosine kinase 57 5e-08
CE04603 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 57 5e-08
At5g58940 [T] KOG1187 Serine/threonine protein kinase 57 5e-08
At4g38230 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 57 5e-08
At4g32710 [T] KOG1187 Serine/threonine protein kinase 57 5e-08
At4g13190 [T] KOG1187 Serine/threonine protein kinase 57 5e-08
At3g45240 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase k... 57 5e-08
At3g09010 [T] KOG1187 Serine/threonine protein kinase 57 5e-08
At2g34180 [T] KOG0583 Serine/threonine protein kinase 57 5e-08
At2g30360 [T] KOG0583 Serine/threonine protein kinase 57 5e-08
At2g28940 [T] KOG1187 Serine/threonine protein kinase 57 5e-08
At1g61950 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 57 5e-08
At1g54960 [T] KOG0198 MEKK and related serine/threonine protein ... 57 5e-08
At1g52290 [T] KOG1187 Serine/threonine protein kinase 57 5e-08
At1g29720 [T] KOG1187 Serine/threonine protein kinase 57 5e-08
YIL095w [T] KOG1989 ARK protein kinase family 57 6e-08
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 57 6e-08
Hs4885489 [T] KOG0192 Tyrosine kinase specific for activated (GT... 57 6e-08
Hs4503787 [T] KOG0197 Tyrosine kinases 57 6e-08
Hs22068916 [T] KOG0696 Serine/threonine protein kinase 57 6e-08
Hs20127450 [T] KOG0696 Serine/threonine protein kinase 57 6e-08
CE28479 [T] KOG0583 Serine/threonine protein kinase 57 6e-08
CE26621 [T] KOG0671 LAMMER dual specificity kinases 57 6e-08
At5g26150 [T] KOG1187 Serine/threonine protein kinase 57 6e-08
At5g25110 [T] KOG0583 Serine/threonine protein kinase 57 6e-08
At5g20050 [T] KOG1187 Serine/threonine protein kinase 57 6e-08
At4g21940 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 57 6e-08
At2g46070 [T] KOG0660 Mitogen-activated protein kinase 57 6e-08
At2g42960 [T] KOG1187 Serine/threonine protein kinase 57 6e-08
At2g38910 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 57 6e-08
At2g35890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 57 6e-08
At1g66910 [T] KOG1187 Serine/threonine protein kinase 57 6e-08
At1g07870 [T] KOG1187 Serine/threonine protein kinase 57 6e-08
7303406 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 57 6e-08
7302199 [T] KOG0197 Tyrosine kinases 57 6e-08
7297611 [T] KOG0614 cGMP-dependent protein kinase 57 6e-08
YBL105c [T] KOG0694 Serine/threonine protein kinase 57 8e-08
SPCC74.03c [T] KOG0583 Serine/threonine protein kinase 57 8e-08
SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-speci... 57 8e-08
Hs7705841 [T] KOG1187 Serine/threonine protein kinase 57 8e-08
Hs5453974 [T] KOG0694 Serine/threonine protein kinase 57 8e-08
Hs4506735 [T] KOG0603 Ribosomal protein S6 kinase 57 8e-08
Hs16950621 [Z] KOG0613 Projectin/twitchin and related proteins 57 8e-08
Hs16950619 [Z] KOG0613 Projectin/twitchin and related proteins 57 8e-08
Hs16950613 [Z] KOG0613 Projectin/twitchin and related proteins 57 8e-08
Hs16950611 [Z] KOG0613 Projectin/twitchin and related proteins 57 8e-08
Hs16950601 [Z] KOG0613 Projectin/twitchin and related proteins 57 8e-08
Hs15149482 [T] KOG1027 Serine/threonine protein kinase and endor... 57 8e-08
CE22810 [T] KOG0194 Protein tyrosine kinase 57 8e-08
CE06504 [T] KOG0194 Protein tyrosine kinase 57 8e-08
CE00847 [T] KOG0583 Serine/threonine protein kinase 57 8e-08
At5g38260 [T] KOG1187 Serine/threonine protein kinase 57 8e-08
At5g01810 [T] KOG0583 Serine/threonine protein kinase 57 8e-08
At4g18700 [T] KOG0583 Serine/threonine protein kinase 57 8e-08
At3g58690 [T] KOG1187 Serine/threonine protein kinase 57 8e-08
At3g24550 [T] KOG1187 Serine/threonine protein kinase 57 8e-08
At3g17420 [T] KOG1187 Serine/threonine protein kinase 57 8e-08
At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 57 8e-08
At3g07070 [T] KOG1187 Serine/threonine protein kinase 57 8e-08
At2g47060 [T] KOG1187 Serine/threonine protein kinase 57 8e-08
At1g67000 [T] KOG1187 Serine/threonine protein kinase 57 8e-08
At1g66920 [T] KOG1187 Serine/threonine protein kinase 57 8e-08
7302464 [R] KOG0586 Serine/threonine protein kinase 57 8e-08
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 56 1e-07
SPCC1259.13 [D] KOG0590 Checkpoint kinase and related serine/thr... 56 1e-07
Hs7657214 [T] KOG0583 Serine/threonine protein kinase 56 1e-07
Hs5453978 [T] KOG0614 cGMP-dependent protein kinase 56 1e-07
Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase 56 1e-07
Hs4507743 [T] KOG0197 Tyrosine kinases 56 1e-07
Hs20428652 [T] KOG0197 Tyrosine kinases 56 1e-07
Hs15011880 [T] KOG0201 Serine/threonine protein kinase 56 1e-07
Hs14042947 [T] KOG0583 Serine/threonine protein kinase 56 1e-07
ECU02g0550 [D] KOG0575 Polo-like serine/threonine protein kinase 56 1e-07
At3g13690 [T] KOG1187 Serine/threonine protein kinase 56 1e-07
At3g02810 [T] KOG1187 Serine/threonine protein kinase 56 1e-07
At2g39110 [T] KOG1187 Serine/threonine protein kinase 56 1e-07
At2g17290 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 56 1e-07
7303915 [T] KOG0694 Serine/threonine protein kinase 56 1e-07
7303914 [T] KOG0694 Serine/threonine protein kinase 56 1e-07
7301734 [T] KOG0694 Serine/threonine protein kinase 56 1e-07
HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase 56 1e-07
Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase 56 1e-07
Hs5032091 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 56 1e-07
Hs4506073 [T] KOG0694 Serine/threonine protein kinase 56 1e-07
Hs21450846 [T] KOG0197 Tyrosine kinases 56 1e-07
Hs21450844 [T] KOG0197 Tyrosine kinases 56 1e-07
Hs21450842 [T] KOG0197 Tyrosine kinases 56 1e-07
Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase 56 1e-07
Hs14758219 [T] KOG0694 Serine/threonine protein kinase 56 1e-07
CE18899 [T] KOG0194 Protein tyrosine kinase 56 1e-07
At5g47850 [T] KOG1187 Serine/threonine protein kinase 56 1e-07
At4g35310 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 56 1e-07
At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 56 1e-07
At4g24480 [T] KOG0192 Tyrosine kinase specific for activated (GT... 56 1e-07
At4g22130 [T] KOG1187 Serine/threonine protein kinase 56 1e-07
At4g09570 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 56 1e-07
At4g02630 [T] KOG1187 Serine/threonine protein kinase 56 1e-07
At3g45790 [T] KOG0198 MEKK and related serine/threonine protein ... 56 1e-07
At2g48010 [T] KOG1187 Serine/threonine protein kinase 56 1e-07
At2g38490 [T] KOG0583 Serine/threonine protein kinase 56 1e-07
At2g31500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 56 1e-07
At2g23030 [T] KOG0583 Serine/threonine protein kinase 56 1e-07
At1g52310 [T] KOG1187 Serine/threonine protein kinase 56 1e-07
7299507 [T] KOG0607 MAP kinase-interacting kinase and related se... 56 1e-07
7298652 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 56 1e-07
7296450 [D] KOG0575 Polo-like serine/threonine protein kinase 56 1e-07
7295585 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 56 1e-07
CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase 56 1e-07
SPAC17G8.14c [T] KOG0694 Serine/threonine protein kinase 55 2e-07
CE29298 [T] KOG0690 Serine/threonine protein kinase 55 2e-07
CE27499 [T] KOG4258 Insulin/growth factor receptor (contains pro... 55 2e-07
CE18646 [T] KOG0690 Serine/threonine protein kinase 55 2e-07
CE06635 [Z] KOG0613 Projectin/twitchin and related proteins 55 2e-07
CE06634 [Z] KOG0613 Projectin/twitchin and related proteins 55 2e-07
At5g63610 [K] KOG0666 Cyclin C-dependent kinase CDK8 55 2e-07
At4g32000 [T] KOG1187 Serine/threonine protein kinase 55 2e-07
At3g62220 [T] KOG1187 Serine/threonine protein kinase 55 2e-07
At3g29160 [T] KOG0583 Serine/threonine protein kinase 55 2e-07
At3g24540 [T] KOG1187 Serine/threonine protein kinase 55 2e-07
At3g18810 [T] KOG1187 Serine/threonine protein kinase 55 2e-07
At1g78290 [T] KOG0583 Serine/threonine protein kinase 55 2e-07
At1g66460 [T] KOG1187 Serine/threonine protein kinase 55 2e-07
At1g45160 [TR] KOG0606 Microtubule-associated serine/threonine k... 55 2e-07
At1g17540 [T] KOG1187 Serine/threonine protein kinase 55 2e-07
At1g06700 [T] KOG1187 Serine/threonine protein kinase 55 2e-07
7300098 [T] KOG4250 TANK binding protein kinase TBK1 55 2e-07
7289880 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 55 2e-07
>YJL057c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 667
Score = 298 bits (762), Expect = 2e-80
Identities = 168/408 (41%), Positives = 240/408 (58%), Gaps = 49/408 (12%)
Query: 22 YNQAYFEYLQAEDGYAGFEDGARRRNSR-------IPEDIFVQGYYQRFFKQVGVLGNGS 74
+++ YF+ L+ + ++ + + + IP+D+F+ GY+++FFK + +LGNG+
Sbjct: 124 FSRRYFQSLERNHRHYALQNDSNNKQGQFSKNKYFIPDDLFIPGYFRKFFKILSLLGNGA 183
Query: 75 RAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHLITYNHVW 134
R VYKV H + ELG FALKKI IG+DM W +C++EVK L+ LT +S++LITYNHVW
Sbjct: 184 RGSVYKVVHTIGNTELGVFALKKIPIGNDMEWFNKCIREVKALSSLTHKSANLITYNHVW 243
Query: 135 LERCPVESLI--LTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNE 192
LE ++S + + DGS D +P +FILQQ+C GGNLED I +VFNR S E
Sbjct: 244 LE---MDSSVGFVRSIDGS--QSDSQEEVPCIFILQQYCSGGNLEDCILRKVFNRFSDTE 298
Query: 193 SRLERRKKLLNHKKS-----RIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLL 247
S ER+KK KK+ +GL+T Q+VSI DIA GL +LHS+ +IHRDLKPSNCLL
Sbjct: 299 SPEERKKKFRTRKKNHGKSGEVGLSTEQLVSIIRDIARGLHELHSIGLIHRDLKPSNCLL 358
Query: 248 LEEF------------DRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTK 295
L F + + + FP VIGD GESQL G+ R TG TGT+EF AP+L
Sbjct: 359 LTPFKSDNENDNVYDREHNSDEFFPSIVIGDLGESQLEGESRLGTGCTGTLEFTAPDLII 418
Query: 296 GA-----------------QFSFKSDIYAFGMILYFVIMGQLPFNSK-DMSAIKHEINEL 337
+++F SD+Y+ GMI YF++ G+LPF + D+ +K I
Sbjct: 419 QGRPVSSSTLPSRSSHTYNEYTFASDMYSLGMICYFIVFGELPFEPQLDIVDLKVRIKNF 478
Query: 338 SFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQIEYQL 385
F E M + H ++ L PID +++L+ +L RP + +E L
Sbjct: 479 RFDTEGMIEKHQAMKLKPIDRRIFHLMDALLQPNNDARPTAKTVEETL 526
>At1g62400 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 345
Score = 90.9 bits (224), Expect = 4e-18
Identities = 57/178 (32%), Positives = 89/178 (49%), Gaps = 18/178 (10%)
Query: 204 HKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCV 263
+KK L+ ++ +A DI+ G++ LHS +IHRDLK +N LL +E +
Sbjct: 132 NKKEPYSLSIETVLRLALDISRGMEYLHSQGVIHRDLKSNNLLLNDEM---------RVK 182
Query: 264 IGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFN 323
+ DFG S L Q R+A G+ GT ++APE+ K ++ K D+Y+FG++L+ + LPF
Sbjct: 183 VADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTTALLPFQ 242
Query: 324 SKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
+ E + P A P+L +L+ + PS RPD S I
Sbjct: 243 GMTPVQAAFAVAEKNERPPLP---------ASCQPALAHLIKRCWSENPSKRPDFSNI 291
>At3g63260 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 391
Score = 83.6 bits (205), Expect = 6e-16
Identities = 48/139 (34%), Positives = 77/139 (54%), Gaps = 10/139 (7%)
Query: 205 KKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVI 264
KK R L + ++ +A D+A GL LHS I+HRD+K N LL +K K I
Sbjct: 199 KKYRAKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLL-------QPNKTLK--I 249
Query: 265 GDFGESQLYGQL-RDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFN 323
DFG +++ Q +D TG TGT+ ++APE+ +G ++ K D+Y+FG+ L+ + +P+
Sbjct: 250 ADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEIYCCDMPYA 309
Query: 324 SKDMSAIKHEINELSFSPE 342
+ I H + + PE
Sbjct: 310 DCSFAEISHAVVHRNLRPE 328
>At5g58950 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 561
Score = 81.3 bits (199), Expect = 3e-15
Identities = 48/131 (36%), Positives = 73/131 (55%), Gaps = 17/131 (12%)
Query: 204 HKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCV 263
HK L ++++ A DIA G++ +HS RIIHRDLKP N L+ EEF
Sbjct: 336 HKPENRSLPLKKLIEFAIDIARGMEYIHSRRIIHRDLKPENVLIDEEFHLK--------- 386
Query: 264 IGDFG---ESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQL 320
I DFG E + L D GT ++APE+ K K+D+Y+FG++L+ ++ G +
Sbjct: 387 IADFGIACEEEYCDMLAD---DPGTYRWMAPEMIKRKPHGRKADVYSFGLVLWEMVAGAI 443
Query: 321 PFNSKDMSAIK 331
P+ +DM+ I+
Sbjct: 444 PY--EDMNPIQ 452
>7290150 [T] KOG0583 Serine/threonine protein kinase
Length = 582
Score = 81.3 bits (199), Expect = 3e-15
Identities = 85/314 (27%), Positives = 137/314 (43%), Gaps = 55/314 (17%)
Query: 71 GNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHLITY 130
G+ + + K+ H LL LGT K+ IG+ H + R VK+LNR +S +
Sbjct: 15 GSANGQPLVKIGHYLLGATLGTGTFGKVKIGE--HQITRVKVAVKILNRQKIKSLDV--- 69
Query: 131 NHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISG 190
V R +++L L ++ + +T +F++ ++ GG L D I
Sbjct: 70 --VGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIV--------- 118
Query: 191 NESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEE 250
+ KL H+ R +QI+S G+ H I+HRDLKP N LL
Sbjct: 119 ------KHGKLQEHQARRF---FQQIIS-------GVDYCHRHMIVHRDLKPENLLL--- 159
Query: 251 FDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSF-KSDIYAFG 309
D I DFG S + S G+ + APE+ G ++ + DI++ G
Sbjct: 160 ------DHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCG 213
Query: 310 MILYFVIMGQLPFNSKDMSAIKHEINELSFS-PEAMSKLHDSLDLAPIDPSLYNLVCEML 368
+ILY ++ G LPF+ + + + +I F PE ++K + NLVC+ML
Sbjct: 214 VILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNK------------QVVNLVCQML 261
Query: 369 NHTPSLRPDSSQIE 382
P R + +I+
Sbjct: 262 QVDPLKRANIEEIK 275
>At3g01490 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 411
Score = 80.9 bits (198), Expect = 4e-15
Identities = 47/139 (33%), Positives = 76/139 (53%), Gaps = 10/139 (7%)
Query: 205 KKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVI 264
K R L + ++ ++ D+A GL LHS +I+HRD+K N LL D+S T K I
Sbjct: 219 KTRRRKLAFKVVIQLSLDLARGLSYLHSQKIVHRDVKTENMLL----DKSRTLK-----I 269
Query: 265 GDFGESQLYGQL-RDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFN 323
DFG ++L D TG TGT+ ++APE+ G+ ++ K D+Y+FG+ L+ + +P+
Sbjct: 270 ADFGVARLEASNPNDMTGETGTLGYMAPEVLNGSPYNRKCDVYSFGICLWEIYCCDMPYP 329
Query: 324 SKDMSAIKHEINELSFSPE 342
S + + + PE
Sbjct: 330 DLSFSEVTSAVVRQNLRPE 348
>At3g20860 [R] KOG0589 Serine/threonine protein kinase
Length = 427
Score = 80.5 bits (197), Expect = 5e-15
Identities = 77/323 (23%), Positives = 140/323 (42%), Gaps = 80/323 (24%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRC----LKEVKLLNR 119
++ V +G G+ + V H ++E + +KKI + RC ++E+ L+++
Sbjct: 15 YEVVEQIGRGAFGSAFLVIH---KSERRKYVVKKIRLAKQTE---RCKLAAIQEMSLISK 68
Query: 120 LTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDT 179
L +S +++ Y W+E+ V I+ +C GG++
Sbjct: 69 L--KSPYIVEYKDSWVEKDCV------------------------CIVTSYCEGGDMTQM 102
Query: 180 IQYQVFNRISGNESRLERRKKLLNHKKSR-IGLTTRQIVSIANDIATGLKQLHSLRIIHR 238
I KKSR + + ++ + + LH+ R++HR
Sbjct: 103 I------------------------KKSRGVFASEEKLCRWMVQLLLAIDYLHNNRVLHR 138
Query: 239 DLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQ 298
DLK SN L +E + +GDFG ++L G+ A+ GT ++ PEL
Sbjct: 139 DLKCSNIFLTKENEVR---------LGDFGLAKLLGKDDLASSMVGTPNYMCPELLADIP 189
Query: 299 FSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDP 358
+ +KSDI++ G ++ V Q F + DM+A+ ++IN S SP + ++ S
Sbjct: 190 YGYKSDIWSLGCCMFEVAAHQPAFKAPDMAALINKINRSSLSP--LPVMYSS-------- 239
Query: 359 SLYNLVCEMLNHTPSLRPDSSQI 381
SL L+ ML P RP ++++
Sbjct: 240 SLKRLIKSMLRKNPEHRPTAAEL 262
>At5g50000 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 385
Score = 79.7 bits (195), Expect = 9e-15
Identities = 46/139 (33%), Positives = 73/139 (52%), Gaps = 10/139 (7%)
Query: 205 KKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVI 264
K R LT + +V +A D+A GL LHS +I+HRD+K N LL DK I
Sbjct: 193 KNRRRKLTFKIVVQLALDLARGLSYLHSQKIVHRDVKTENMLL---------DKTRTVKI 243
Query: 265 GDFGESQLYGQL-RDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFN 323
DFG +++ D TG TGT+ ++APE+ G ++ K D+Y+FG+ L+ + +P+
Sbjct: 244 ADFGVARVEASNPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYP 303
Query: 324 SKDMSAIKHEINELSFSPE 342
S + + + P+
Sbjct: 304 DLTFSEVTSAVVRQNLRPD 322
>Hs4506103 [J] KOG1033 eIF-2alpha kinase PEK/EIF2AK3
Length = 551
Score = 78.2 bits (191), Expect = 3e-14
Identities = 76/323 (23%), Positives = 139/323 (42%), Gaps = 62/323 (19%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEE 123
FK++ ++G+G V+K KH + + T+ +K++ ++ + +EVK L +L +
Sbjct: 267 FKEIELIGSGGFGQVFKAKHRI---DGKTYVIKRVKYNNE-----KAEREVKALAKL--D 316
Query: 124 SSHLITYNHVW--LERCPV---ESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLED 178
+++ YN W + P +SL + D + + +FI +FC G LE
Sbjct: 317 HVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQ 376
Query: 179 TIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHR 238
I+ + R E+ K+L + + I G+ +HS ++IHR
Sbjct: 377 WIE----------KRRGEKLDKVL-------------ALELFEQITKGVDYIHSKKLIHR 413
Query: 239 DLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQ 298
DLKPSN L++ + IGDFG T S GT+ +++PE
Sbjct: 414 DLKPSNIFLVDT---------KQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQD 464
Query: 299 FSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDP 358
+ + D+YA G+IL + + H + + + + L D + D
Sbjct: 465 YGKEVDLYALGLIL---------------AELLHVCDTAFETSKFFTDLRDGIISDIFDK 509
Query: 359 SLYNLVCEMLNHTPSLRPDSSQI 381
L+ ++L+ P RP++S+I
Sbjct: 510 KEKTLLQKLLSKKPEDRPNTSEI 532
>At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 438
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/140 (38%), Positives = 76/140 (53%), Gaps = 15/140 (10%)
Query: 201 LLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLR--IIHRDLKPSNCLLLEEFDRSDTDK 258
L + K + GLT V+ A DIA G+ LH+ IIHRDLKP N LL+ S D
Sbjct: 245 LHQYLKEKGGLTPTTAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVN----SSADH 300
Query: 259 FPKCVIGDFGESQLYG-----QLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILY 313
+GDFG S+L + TG TG+ ++APE+ K ++ K D+++F MILY
Sbjct: 301 LK---VGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRRYDKKVDVFSFAMILY 357
Query: 314 FVIMGQLPF-NSKDMSAIKH 332
++ G+ PF N + A KH
Sbjct: 358 EMLEGEPPFANHEPYEAAKH 377
>CE26649 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 648
Score = 76.6 bits (187), Expect = 7e-14
Identities = 56/186 (30%), Positives = 90/186 (48%), Gaps = 22/186 (11%)
Query: 198 RKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTD 257
R+ L+ K R +T + + I G+ LH L IIHRD+K N L ++
Sbjct: 120 RRSLMELHKRRKAVTEPEARYFTHQIVDGVLYLHDLNIIHRDMKLGNLFLNDDL------ 173
Query: 258 KFPKCVIGDFG-ESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI 316
IGDFG + + G R T GT ++APE+ A SF+ DI+A G ILY ++
Sbjct: 174 ---VVKIGDFGLATTVNGDERKKT-LCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILL 229
Query: 317 MGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRP 376
GQ PF SK + I +++ +++ P+ +L+ +ML+ P+ RP
Sbjct: 230 FGQPPFESKSLEETYSRIRHNNYTIPSIA----------TQPAA-SLIRKMLDPEPTRRP 278
Query: 377 DSSQIE 382
+ Q++
Sbjct: 279 TAKQVQ 284
>At4g14780 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 364
Score = 76.3 bits (186), Expect = 1e-13
Identities = 42/126 (33%), Positives = 73/126 (57%), Gaps = 12/126 (9%)
Query: 198 RKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTD 257
++ L+ HK ++ + ++ +A D+A GL LHS +I+HRD+K N LL D
Sbjct: 167 KQHLIRHKSKKLAF--KAVIKLALDLARGLSYLHSEKIVHRDVKTENMLL-------DAQ 217
Query: 258 KFPKCVIGDFGESQLYG-QLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI 316
K K I DFG +++ +D TG TGT+ ++APE+ G ++ + D+Y+FG+ L+ +
Sbjct: 218 KNLK--IADFGVARVEALNPKDMTGETGTLGYMAPEVIDGKPYNRRCDVYSFGICLWEIY 275
Query: 317 MGQLPF 322
+P+
Sbjct: 276 CCDMPY 281
>SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 683
Score = 75.1 bits (183), Expect = 2e-13
Identities = 57/187 (30%), Positives = 94/187 (49%), Gaps = 23/187 (12%)
Query: 199 KKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDK 258
K L+ + R LT ++ + I LK +H R+IHRDLK N +L D S+ K
Sbjct: 123 KSLMELLRKRKQLTEPEVRYLMMQILGALKYMHKKRVIHRDLKLGNIML----DESNNVK 178
Query: 259 FPKCVIGDFGESQLY--GQLRDATGSTGTVEFVAPELTKGAQ--FSFKSDIYAFGMILYF 314
IGDFG + L + R T GT ++APE+ ++ SF+ D+++ G+++Y
Sbjct: 179 -----IGDFGLAALLMDDEERKMT-ICGTPNYIAPEILFNSKEGHSFEVDLWSAGVVMYA 232
Query: 315 VIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSL 374
+++G+ PF K++ I +I S+S ++D I +L+ +L H PS+
Sbjct: 233 LLIGKPPFQDKEVKTIYRKIKANSYS------FPSNVD---ISAEAKDLISSLLTHDPSI 283
Query: 375 RPDSSQI 381
RP I
Sbjct: 284 RPSIDDI 290
>At3g22750 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 378
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/139 (30%), Positives = 76/139 (54%), Gaps = 10/139 (7%)
Query: 205 KKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVI 264
+ R L + +V +A D++ GL LHS RI+HRD+K N LL ++ R+ I
Sbjct: 186 RNRRKKLAFKVVVQLALDLSRGLSYLHSERIVHRDVKTENMLL--DYQRN-------LKI 236
Query: 265 GDFGESQLYGQL-RDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFN 323
DFG +++ Q +D TG TGT+ ++APE+ G ++ + D+Y+FG+ L+ + +P+
Sbjct: 237 ADFGVARVEAQNPKDMTGETGTLGYMAPEVLDGKPYNRRCDVYSFGICLWEIYCCDMPYP 296
Query: 324 SKDMSAIKHEINELSFSPE 342
+ + + + P+
Sbjct: 297 DLSFADVSSAVVRQNLRPD 315
>7293761 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 977
Score = 74.3 bits (181), Expect = 4e-13
Identities = 51/172 (29%), Positives = 87/172 (49%), Gaps = 34/172 (19%)
Query: 159 TTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVS 218
T P I+ +FC G L++ + K+ ++ L +R +VS
Sbjct: 217 TQSPVFCIIMEFCPYGPLQNIL------------------------KEEQVMLPSR-LVS 251
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRD 278
+ IA G++ LHS +IIHRDLK N L+ T++ K I DFG S+ + ++
Sbjct: 252 WSKQIALGMQYLHSHKIIHRDLKSPNILI-------STNEVVK--ISDFGTSREWNEIST 302
Query: 279 ATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAI 330
GTV ++APE+ + S K DI+++G++L+ ++ ++P+ D SAI
Sbjct: 303 KMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAI 354
>Hs5453970 [T] KOG0694 Serine/threonine protein kinase
Length = 676
Score = 73.9 bits (180), Expect = 5e-13
Identities = 78/302 (25%), Positives = 136/302 (44%), Gaps = 66/302 (21%)
Query: 43 ARRRNSRIPEDIFVQGYYQRFFKQVGVLG------NGSRAVVYK------VKHMLLENEL 90
+RR +S E + G YQ F K+ GV G +G+ +++ + + + L
Sbjct: 299 SRRSDSASSEPV---GIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVL 355
Query: 91 GTFALKKICIGD-DMHWLYRCLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILT--- 146
G + K+ +G+ Y +K +K L ++ +E VE +LT
Sbjct: 356 GKGSFGKVLLGELKGRGEYSAIKALKKDVVLIDDD----------VECTMVEKRVLTLAA 405
Query: 147 QNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKK 206
+N + + T ++F + +F GG+L IQ ++ R E +
Sbjct: 406 ENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQ---------DKGRFELYRATF---- 452
Query: 207 SRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGD 266
A +I GL+ LHS II+RDLK N LL D+ I D
Sbjct: 453 ------------YAAEIMCGLQFLHSKGIIYRDLKLDNVLL---------DRDGHIKIAD 491
Query: 267 FG--ESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNS 324
FG + ++G+ R +T GT +++APE+ +G +++F D ++FG++LY +++GQ PF+
Sbjct: 492 FGMCKENIFGESRAST-FCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHG 550
Query: 325 KD 326
D
Sbjct: 551 DD 552
>Hs4504101 [T] KOG0986 G protein-coupled receptor kinase
Length = 576
Score = 73.9 bits (180), Expect = 5e-13
Identities = 48/146 (32%), Positives = 69/146 (46%), Gaps = 19/146 (13%)
Query: 210 GLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGE 269
G + V A +I GL+ LH RI++RDLKP N LL D I D G
Sbjct: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL---------DDHGHIRISDLGL 332
Query: 270 SQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSA 329
+ + + G GTV ++APE+ K +++F D +A G +LY +I GQ PF +
Sbjct: 333 AVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKI 392
Query: 330 IKHEINEL----------SFSPEAMS 345
+ E+ L FSP+A S
Sbjct: 393 KREEVERLVKEVPEEYSERFSPQARS 418
>Hs14735945 [T] KOG0694 Serine/threonine protein kinase
Length = 676
Score = 73.2 bits (178), Expect = 8e-13
Identities = 78/302 (25%), Positives = 136/302 (44%), Gaps = 66/302 (21%)
Query: 43 ARRRNSRIPEDIFVQGYYQRFFKQVGVLG------NGSRAVVYK------VKHMLLENEL 90
+RR +S E + G YQ F K+ GV G +G+ +++ + + + L
Sbjct: 299 SRRSDSASSEPV---GIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVL 355
Query: 91 GTFALKKICIGD-DMHWLYRCLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILT--- 146
G + K+ +G+ Y +K +K L ++ +E VE +LT
Sbjct: 356 GKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDD----------VECTMVEKRVLTLAA 405
Query: 147 QNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKK 206
+N + + T ++F + +F GG+L IQ ++ R E +
Sbjct: 406 ENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQ---------DKGRFELYRATF---- 452
Query: 207 SRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGD 266
A +I GL+ LHS II+RDLK N LL D+ I D
Sbjct: 453 ------------YAAEIMCGLQFLHSKGIIYRDLKLDNVLL---------DRDGHIKIAD 491
Query: 267 FG--ESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNS 324
FG + ++G+ R +T GT +++APE+ +G +++F D ++FG++LY +++GQ PF+
Sbjct: 492 FGMCKENIFGESRAST-FCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHG 550
Query: 325 KD 326
D
Sbjct: 551 DD 552
>Hs19923134 [T] KOG4250 TANK binding protein kinase TBK1
Length = 745
Score = 72.8 bits (177), Expect = 1e-12
Identities = 43/124 (34%), Positives = 71/124 (56%), Gaps = 6/124 (4%)
Query: 199 KKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDK 258
+KLLN ++ GL QI+S+ +DI +G++ LH +IIHRDLKP N ++L++ K
Sbjct: 104 RKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPEN-IVLQDVGGKIIHK 162
Query: 259 FPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMG 318
I D G ++ Q T GT++++APEL + ++ D ++FG +++ I G
Sbjct: 163 -----IIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAG 217
Query: 319 QLPF 322
PF
Sbjct: 218 YRPF 221
>At1g67890 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 738
Score = 72.8 bits (177), Expect = 1e-12
Identities = 46/127 (36%), Positives = 75/127 (58%), Gaps = 13/127 (10%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLH--SLRIIHRDLKPSNCLLLEEFDRSDTD 257
+LL KS++ L R + +A+DIA G+ LH S IIHRDLK SN L+ DR+ T
Sbjct: 571 RLLQRNKSKLDLRRR--IHMASDIARGMNYLHHCSPPIIHRDLKSSNLLV----DRNWTV 624
Query: 258 KFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIM 317
K + DFG S++ + T GT +++APE+ + KSD+Y+FG++L+ ++
Sbjct: 625 K-----VADFGLSRIKHETYLTTNGRGTPQWMAPEVLRNEAADEKSDVYSFGVVLWELVT 679
Query: 318 GQLPFNS 324
++P+ +
Sbjct: 680 EKIPWEN 686
>Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 966
Score = 72.4 bits (176), Expect = 1e-12
Identities = 43/120 (35%), Positives = 66/120 (54%), Gaps = 9/120 (7%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
+T R +V + IA+G+ LH +IIHRDLK N L+ +D K I DFG S
Sbjct: 251 ITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTH----TDAVK-----ISDFGTS 301
Query: 271 QLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAI 330
+ GTV ++APE+ + S K DI++FG++L+ ++ G++P+ D SAI
Sbjct: 302 KELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI 361
>CE07285 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 615
Score = 72.0 bits (175), Expect = 2e-12
Identities = 52/184 (28%), Positives = 80/184 (43%), Gaps = 20/184 (10%)
Query: 198 RKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTD 257
+ L+ K R LT + +A G+K LH+L+IIHRDLK N L E
Sbjct: 117 KNSLMELNKQRGPLTEHEARFYTIQVAEGVKHLHNLQIIHRDLKLGNLFLNEHL------ 170
Query: 258 KFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIM 317
+ IGDFG + + GT ++APE+ +F+ DI+A G ILY ++
Sbjct: 171 ---QVKIGDFGLATFCEKNEKKMTRGGTPNYIAPEVLNETGHAFEVDIWAIGCILYVLLF 227
Query: 318 GQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPD 377
G PF S+ + I K +D + P+ L+ +L+ P RP
Sbjct: 228 GSPPFESRRVQETYVRI-----------KNNDYVVPENASPTANRLIRSLLDPVPDRRPT 276
Query: 378 SSQI 381
+ +
Sbjct: 277 AEAV 280
>Hs4758128_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 385
Score = 72.0 bits (175), Expect = 2e-12
Identities = 67/233 (28%), Positives = 103/233 (43%), Gaps = 45/233 (19%)
Query: 91 GTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILTQNDG 150
G FA+ K C+ Y LK +K +E H+I L R +++L +
Sbjct: 55 GNFAVVKECVERSTAREY-ALKIIKKSKCRGKE--HMIQNEVSILRRVKHPNIVLLIEE- 110
Query: 151 SSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIG 210
MD+PT + +++ + +GG+L D I S
Sbjct: 111 ----MDVPTEL---YLVMELVKGGDLFDAIT-------------------------STNK 138
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
T R + ++A+ +K LHSL I+HRD+KP N L+ E D S + K +GDFG +
Sbjct: 139 YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLK-----LGDFGLA 193
Query: 271 QLY-GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
+ G L GT +VAPE+ + K DI+A G+I Y ++ G PF
Sbjct: 194 TIVDGPLYTV---CGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPF 243
>HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 71.6 bits (174), Expect = 2e-12
Identities = 55/187 (29%), Positives = 89/187 (47%), Gaps = 23/187 (12%)
Query: 197 RRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDT 256
RR+ LL K R LT + I G + LH R+IHRDLK N L E+ +
Sbjct: 134 RRRSLLEPHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLE---- 189
Query: 257 DKFPKCVIGDFGESQL--YGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYF 314
IGDFG + Y R T GT ++APE+ + SF+ D+++ G I+Y
Sbjct: 190 -----VKIGDFGLATKVEYDGERKKT-LCGTPNYIAPEVLSKKEHSFEVDVWSIGCIMYT 243
Query: 315 VIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSL 374
+++G+ PF + S +K + + ++ K I+P +L+ +ML P+
Sbjct: 244 LLVGKPPF---ETSCLKETYLRIKKNEYSIPK--------HINPVAASLIQKMLQTDPTA 292
Query: 375 RPDSSQI 381
RP +++
Sbjct: 293 RPTINEL 299
>CE22877 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 632
Score = 71.6 bits (174), Expect = 2e-12
Identities = 52/186 (27%), Positives = 83/186 (43%), Gaps = 24/186 (12%)
Query: 198 RKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTD 257
R+ L+ K R +T + I G+ LH+L+I+HRDLK N L +E
Sbjct: 118 RRSLMELHKRRKAVTEPEARYFTYQIVEGVLYLHNLKIVHRDLKLGNLFLNDEL------ 171
Query: 258 KFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIM 317
+ IGDFG + GT ++APE+ SF+ D++A G ILY ++
Sbjct: 172 ---QVKIGDFGLATTCDNDERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLF 228
Query: 318 GQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPS--LYNLVCEMLNHTPSLR 375
G PF SK + E S++ ++ + P S L+ +L+ PS R
Sbjct: 229 GHPPFESKSLE-------------ETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRR 275
Query: 376 PDSSQI 381
P++ +
Sbjct: 276 PNARAV 281
>At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 407
Score = 71.6 bits (174), Expect = 2e-12
Identities = 44/133 (33%), Positives = 75/133 (56%), Gaps = 12/133 (9%)
Query: 199 KKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDK 258
++ L +++R + + V A D+A G+ +H IHRDLK N L+ DK
Sbjct: 213 RQFLTRRQNR-AVPLKLAVKQALDVARGMAYVHGRNFIHRDLKSDNLLI-------SADK 264
Query: 259 FPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMG 318
K I DFG +++ Q T TGT ++APE+ + ++ K D+Y+FG++L+ +I G
Sbjct: 265 SIK--IADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRAYNQKVDVYSFGIVLWELITG 322
Query: 319 QLPFNSKDMSAIK 331
LPF ++M+A++
Sbjct: 323 LLPF--QNMTAVQ 333
>At2g35050_2 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 300
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/163 (31%), Positives = 82/163 (50%), Gaps = 26/163 (15%)
Query: 173 GGNLEDTIQYQV---FNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQ 229
GG L +Y V + + L+RRK+L+ IA D A G++
Sbjct: 92 GGTLATVTEYMVNGSLRHVLLSNRHLDRRKRLI----------------IAMDAAFGMEY 135
Query: 230 LHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFV 289
LHS I+H DLK N L+ + D + P C +GDFG S++ G GT+ ++
Sbjct: 136 LHSKSIVHFDLKCDNLLV----NLKDPAR-PICKVGDFGLSKIKRNTLVTGGVRGTLPWM 190
Query: 290 APELTKG--AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAI 330
APEL G ++ S K D+++FG++L+ ++ G+ P+ + AI
Sbjct: 191 APELLSGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAI 233
>CE18366 [T] KOG0583 Serine/threonine protein kinase
Length = 331
Score = 71.2 bits (173), Expect = 3e-12
Identities = 53/213 (24%), Positives = 97/213 (44%), Gaps = 43/213 (20%)
Query: 163 YMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIAND 222
++ + +FC GG+L L + KK+ + T RQ ++
Sbjct: 110 HIIFVTEFCAGGDL------------------LRKMKKIKTMSEENAKFTFRQFIA---- 147
Query: 223 IATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS 282
L L S I+HRDLK N L DK+ +GDFG S++ +
Sbjct: 148 ---ALMHLQSYNIVHRDLKCENIFL---------DKYENVKLGDFGFSRILKPGEKSGTF 195
Query: 283 TGTVEFVAPELTKGAQFSFKS-DIYAFGMILYFVIMGQLPFNSKDMSAI--KHEINELSF 339
G+ +VAPE+ +G ++S + D+++ G+ILY +++G +PF+ +D + + + +++ F
Sbjct: 196 CGSRAYVAPEILRGREYSGNAVDVWSTGVILYIMLVGTMPFDDRDPTRMIERQLAHKIKF 255
Query: 340 SPEAMSKLHD-SLDLAPIDP-----SLYNLVCE 366
+ +H +L L + P Y +CE
Sbjct: 256 GKTCTASIHSKALILEILQPHAPNRPTYKAICE 288
>At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 553
Score = 71.2 bits (173), Expect = 3e-12
Identities = 40/168 (23%), Positives = 84/168 (49%), Gaps = 18/168 (10%)
Query: 214 RQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY 273
+ ++ +A D++ G+ LH IIHRDLK +N L+ D+ + DFG +++
Sbjct: 371 QSLLKVALDVSKGMNYLHQNNIIHRDLKTANLLM---------DEHEVVKVADFGVARVQ 421
Query: 274 GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHE 333
+ T TGT ++APE+ + + ++D++++ ++L+ ++ G+LP++
Sbjct: 422 TESGVMTAETGTYRWMAPEVIEHKPYDHRADVFSYAIVLWELLTGELPYSYLTPLQAAVG 481
Query: 334 INELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
+ + P+ + H P L L+ + P+LRP+ ++I
Sbjct: 482 VVQKGLRPKIPKETH---------PKLTELLEKCWQQDPALRPNFAEI 520
>7295638 [T] KOG0603 Ribosomal protein S6 kinase
Length = 911
Score = 71.2 bits (173), Expect = 3e-12
Identities = 73/290 (25%), Positives = 117/290 (40%), Gaps = 65/290 (22%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEE 123
F+ + VLG GS V+ V+ ++ + GT K+ L + +VK R T E
Sbjct: 199 FELLRVLGEGSFGKVFLVRK-IIGKDAGTLYAMKV--------LKKATLKVKDRVRSTNE 249
Query: 124 SSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQ 183
L H ++ R Q G ++++ F RGG+L
Sbjct: 250 RKILADVGHAFIVRLHYAF----QTPGK------------LYLILDFLRGGDL------- 286
Query: 184 VFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPS 243
F R+S + T + ++A + LH+L II+RDLKP
Sbjct: 287 -FTRLS-----------------KEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPE 328
Query: 244 NCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKS 303
N LL D+ + DFG S+ GTVE++APE+ F +
Sbjct: 329 NILL---------DEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAA 379
Query: 304 DIYAFGMILYFVIMGQLPFNSKDMSAIKHEINEL------SFSPEAMSKL 347
D ++FG+++Y ++ G LPF+ + ++I + SPEA S L
Sbjct: 380 DWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLL 429
Score = 56.6 bits (135), Expect = 8e-08
Identities = 48/173 (27%), Positives = 78/173 (44%), Gaps = 26/173 (15%)
Query: 218 SIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLR 277
++ IA+ + LH ++HRDLKPSN + +T K C +G QLR
Sbjct: 673 AVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKL--CDLG------FAKQLR 724
Query: 278 DATG----STGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF-----NSKDMS 328
G T FVAPE+ K + DI++ G++LY ++ G+ PF +S D+
Sbjct: 725 ADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVI 784
Query: 329 AIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
+ ++ F+ S A I L+ +ML+ P RP +++I
Sbjct: 785 LKRIGSGQIDFT---------SSRWALISVPAKELLRQMLHIVPENRPTAARI 828
>7290313 [T] KOG0193 Serine/threonine protein kinase RAF
Length = 739
Score = 71.2 bits (173), Expect = 3e-12
Identities = 53/188 (28%), Positives = 101/188 (53%), Gaps = 33/188 (17%)
Query: 216 IVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG----ESQ 271
++ I +A G+ LH+ IIHRDLK +N L E+ IGDFG +++
Sbjct: 525 LIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDL---------SVKIGDFGLATAKTR 575
Query: 272 LYGQLRDATGSTGTVEFVAPELTKGAQ---FSFKSDIYAFGMILYFVIMGQLPF---NSK 325
G+ + A TG++ ++APE+ + + +SF+SD+YAFG+++Y ++ LP+ ++K
Sbjct: 576 WSGE-KQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNK 634
Query: 326 DM-------SAIKHEINEL-SFSPEAMSKL-HDSLDLAPIDPSLY----NLVCEMLNHTP 372
D ++ +++++ S +P+A+ +L D + P D L+ N++ ML P
Sbjct: 635 DQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLP 694
Query: 373 SLRPDSSQ 380
+ +S+
Sbjct: 695 KIHRSASE 702
>Hs4505195 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 847
Score = 70.9 bits (172), Expect = 4e-12
Identities = 53/174 (30%), Positives = 94/174 (53%), Gaps = 16/174 (9%)
Query: 216 IVSIANDIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQL 272
+V+ A IA G+ LH + +IHRDLK +N LLL+ + SD + I DFG ++
Sbjct: 215 LVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIE-SDDMEHKTLKITDFGLARE 273
Query: 273 YGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKH 332
+ + + + GT ++APE+ K + FS SD+++FG++L+ ++ G++P+ D A+ +
Sbjct: 274 WHKTTQMSAA-GTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAY 332
Query: 333 EINELSFSPEAMSKLHDSLDLAPIDPSLY-NLVCEMLNHTPSLRPDSSQIEYQL 385
+ A++KL +L + P + L+ + P RPD + I QL
Sbjct: 333 GV--------AVNKL--TLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQL 376
>At4g31170 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 412
Score = 70.9 bits (172), Expect = 4e-12
Identities = 43/127 (33%), Positives = 70/127 (54%), Gaps = 11/127 (8%)
Query: 205 KKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVI 264
K+ + + V A D+A G+ +H IHRDLK N L+ DRS I
Sbjct: 223 KRQNRAVPLKLAVMQALDVARGMAYVHERNFIHRDLKSDNLLI--SADRS-------IKI 273
Query: 265 GDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNS 324
DFG +++ Q T TGT ++APE+ + ++ K D+Y+FG++L+ +I G LPF
Sbjct: 274 ADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPF-- 331
Query: 325 KDMSAIK 331
++M+A++
Sbjct: 332 QNMTAVQ 338
>Hs14749517 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 922
Score = 70.5 bits (171), Expect = 5e-12
Identities = 55/175 (31%), Positives = 97/175 (55%), Gaps = 18/175 (10%)
Query: 216 IVSIANDIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSD-TDKFPKCVIGDFGESQ 271
+V+ A IA G+ LH + IIHRDLK SN L+L++ + D ++K K I DFG ++
Sbjct: 46 LVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILK--ITDFGLAR 103
Query: 272 LYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIK 331
+ + + + GT ++APE+ + + FS SD++++G++L+ ++ G++PF D A+
Sbjct: 104 EWHRTTKMSAA-GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVA 162
Query: 332 HEINELSFSPEAMSKLHDSLDLAPIDPSLY-NLVCEMLNHTPSLRPDSSQIEYQL 385
+ + AM+KL +L + P + L+ + N P RP + I QL
Sbjct: 163 YGV--------AMNKL--ALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 207
>At3g46930 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 475
Score = 70.5 bits (171), Expect = 5e-12
Identities = 41/122 (33%), Positives = 64/122 (51%), Gaps = 15/122 (12%)
Query: 204 HKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCV 263
HK + L Q++ DIA G++ +HS I+H+DLKP N L+ +F
Sbjct: 251 HKLEQKSLPLEQLIDFGLDIAKGMEYIHSREIVHQDLKPENVLIDNDFHLK--------- 301
Query: 264 IGDFG---ESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQL 320
I DFG E + L D + GT ++APE+ K K D+Y+FG++L+ ++ G L
Sbjct: 302 IADFGIACEEEYCDVLGD---NIGTYRWMAPEVLKRIPHGRKCDVYSFGLLLWEMVAGAL 358
Query: 321 PF 322
P+
Sbjct: 359 PY 360
>At1g79570_2 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 298
Score = 70.5 bits (171), Expect = 5e-12
Identities = 50/164 (30%), Positives = 82/164 (49%), Gaps = 27/164 (16%)
Query: 173 GGNLEDTIQYQVFNRISG----NESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLK 228
GG L +Y V + + L+RRK+L+ IA D A G++
Sbjct: 89 GGTLATVTEYMVDGSLRHVLVRKDRHLDRRKRLI----------------IAMDAAFGME 132
Query: 229 QLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEF 288
LHS +H DLK N L+ + D + P C +GDFG S++ + G GT+ +
Sbjct: 133 YLHSKNTVHFDLKCDNLLV----NLKDPSR-PICKVGDFGLSKIKRNTLVSGGVRGTLPW 187
Query: 289 VAPELTKG--AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAI 330
+APEL G ++ S K D+++FG++L+ ++ G+ P+ + AI
Sbjct: 188 MAPELLNGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYGAI 231
>Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 70.1 bits (170), Expect = 7e-12
Identities = 78/291 (26%), Positives = 122/291 (41%), Gaps = 66/291 (22%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEE 123
F+ + VLG GS V+ VK + + +A+K L + +V+ R E
Sbjct: 68 FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKV---------LKKATLKVRDRVRTKME 118
Query: 124 SSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQ 183
L+ NH ++ V+ Q +G ++++ F RGG+L
Sbjct: 119 RDILVEVNHPFI----VKLHYAFQTEGK------------LYLILDFLRGGDL------- 155
Query: 184 VFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPS 243
F R+S + T + ++A L LHSL II+RDLKP
Sbjct: 156 -FTRLS-----------------KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPE 197
Query: 244 NCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQLRDATGSTGTVEFVAPELTKGAQFSFK 302
N LL EE TD FG S + + A GTVE++APE+ +
Sbjct: 198 NILLDEEGHIKLTD---------FGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQS 248
Query: 303 SDIYAFGMILYFVIMGQLPFNSKDMS-----AIKHEINELSF-SPEAMSKL 347
+D ++FG++++ ++ G LPF KD +K ++ F SPEA S L
Sbjct: 249 ADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLL 299
Score = 62.8 bits (151), Expect = 1e-09
Identities = 51/195 (26%), Positives = 86/195 (43%), Gaps = 41/195 (21%)
Query: 136 ERCPVESLILTQNDGSSVNM----DIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGN 191
+R P E + + G N+ D+ Y++++ + +GG L D I Q F
Sbjct: 457 KRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKF------ 510
Query: 192 ESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEF 251
+ R+ ++ I ++ LH+ ++HRDLKPSN L ++E
Sbjct: 511 -------------------FSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDES 551
Query: 252 DRSDTDKFPKCVIGDFGESQLYGQLRDATG----STGTVEFVAPELTKGAQFSFKSDIYA 307
++ + I DFG ++ QLR G T FVAPE+ K + DI++
Sbjct: 552 GNPESIR-----ICDFGFAK---QLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWS 603
Query: 308 FGMILYFVIMGQLPF 322
G++LY ++ G PF
Sbjct: 604 LGVLLYTMLTGYTPF 618
>Hs20536136 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 1036
Score = 70.1 bits (170), Expect = 7e-12
Identities = 67/243 (27%), Positives = 116/243 (47%), Gaps = 29/243 (11%)
Query: 162 PYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIAN 221
P++ ++ +F RGG L + N + RR + + +V+ A
Sbjct: 194 PHLCLVLEFARGGALNRALA--AANAAPDPRAPGPRRARRI---------PPHVLVNWAV 242
Query: 222 DIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSDT-DKFPKCVIGDFGESQLYGQLR 277
IA G+ LH + I+HRDLK SN LLLE+ + D +K K I DFG ++ + +
Sbjct: 243 QIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLK--ITDFGLAREWHRTT 300
Query: 278 DATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINEL 337
+ + GT ++APE+ K + FS SDI+++G++L+ ++ G++P+ D A+ + +
Sbjct: 301 KMS-TAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGV--- 356
Query: 338 SFSPEAMSKLHDSLDLAPIDPSLY-NLVCEMLNHTPSLRPDSSQIEYQLXXXXXXXXXXX 396
A++KL +L + P + L+ E P +RP + I QL
Sbjct: 357 -----AVNKL--TLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEM 409
Query: 397 XQE 399
QE
Sbjct: 410 PQE 412
>CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 1101
Score = 70.1 bits (170), Expect = 7e-12
Identities = 40/126 (31%), Positives = 65/126 (50%), Gaps = 8/126 (6%)
Query: 201 LLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFP 260
+L+ +K R+ T Q + I L+ LH L I+H DLKP N LL D FP
Sbjct: 857 ILSSEKGRLSERTTQF--LVAQILEALRYLHHLNIVHCDLKPENILLNSNSD------FP 908
Query: 261 KCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQL 320
+ + DFG +++ G+ GT ++APE+ + F+ D+++ G+I+Y + G
Sbjct: 909 QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSGTF 968
Query: 321 PFNSKD 326
PFN +
Sbjct: 969 PFNEDE 974
>At5g01850 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 356
Score = 70.1 bits (170), Expect = 7e-12
Identities = 55/175 (31%), Positives = 80/175 (45%), Gaps = 30/175 (17%)
Query: 217 VSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQL 276
+S A DIA L LH+ IIHRDLKP N LL T+ + DFG ++
Sbjct: 144 LSFALDIARALHCLHANGIIHRDLKPDNLLL--------TENHKSVKLADFGLAREESVT 195
Query: 277 RDATGSTGTVEFVAPEL--------TKGAQFSFKSDIYAFGMILYFVIMGQLPFN--SKD 326
T TGT ++APEL + ++ K D+Y+FG++L+ ++ ++PF S
Sbjct: 196 EMMTAETGTYRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRMPFEGMSNL 255
Query: 327 MSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
+A E PE +S PSL +V P++RP SQI
Sbjct: 256 QAAYAAAFKERPVMPEGIS------------PSLAFIVQSCWVEDPNMRPSFSQI 298
>At2g31010 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 375
Score = 70.1 bits (170), Expect = 7e-12
Identities = 51/157 (32%), Positives = 82/157 (51%), Gaps = 26/157 (16%)
Query: 197 RRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDT 256
++KKL H++ R+ DI GL +H ++I+HRDLK +NCL+
Sbjct: 147 QKKKLSWHRRLRM----------LRDICRGLMCIHRMKIVHRDLKSANCLV--------- 187
Query: 257 DKFPKCVIGDFGESQLY--GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYF 314
DK I DFG S++ ++D T S GT E++APEL + F+ K DI++ G+I++
Sbjct: 188 DKHWTVKICDFGLSRIMTDENMKD-TSSAGTPEWMAPELIRNRPFTEKCDIFSLGVIMWE 246
Query: 315 VIMGQLPFN----SKDMSAIKHEINELSFSPEAMSKL 347
+ + P+ K + A+ HE + L +SKL
Sbjct: 247 LSTLRKPWEGVPPEKVVFAVAHEGSRLEIPDGPLSKL 283
>Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase
Length = 292
Score = 70.1 bits (170), Expect = 7e-12
Identities = 80/317 (25%), Positives = 132/317 (41%), Gaps = 76/317 (23%)
Query: 69 VLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLK-EVKLLNRLTEESSHL 127
V+G GS V VKH + + +KK+ + + R + E +LL++L + ++
Sbjct: 11 VVGKGSYGEVTLVKH---RRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL--KHPNI 65
Query: 128 ITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNR 187
+TY W DG ++I+ FC GG+L
Sbjct: 66 VTYKESW-----------EGGDG------------LLYIVMGFCEGGDLY---------- 92
Query: 188 ISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLL 247
+ L +K ++ L Q+V IA L+ LH I+HRDLK N L
Sbjct: 93 ------------RKLKEQKGQL-LPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFL 139
Query: 248 LEEFDRSDTDKFPKCVIGDFGESQLYGQLRD-ATGSTGTVEFVAPELTKGAQFSFKSDIY 306
R++ K +GD G +++ D A+ GT +++PEL +++KSD++
Sbjct: 140 T----RTNIIK-----VGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVW 190
Query: 307 AFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPID--PSLYNLV 364
A G +Y + + FN+KDM+++ + I + L P D P L L+
Sbjct: 191 ALGCCVYEMATLKHAFNAKDMNSLVYRI------------IEGKLPAMPRDYSPELAELI 238
Query: 365 CEMLNHTPSLRPDSSQI 381
ML+ P RP I
Sbjct: 239 RTMLSKRPEERPSVRSI 255
>YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 705
Score = 69.7 bits (169), Expect = 9e-12
Identities = 56/176 (31%), Positives = 88/176 (49%), Gaps = 21/176 (11%)
Query: 201 LLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFP 260
L+ K R LT ++ I +K +HS R+IHRDLK N FD + K
Sbjct: 166 LMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIF----FDSNYNLK-- 219
Query: 261 KCVIGDFGESQLYGQLRDATGST-GTVEFVAPELTKGAQ--FSFKSDIYAFGMILYFVIM 317
IGDFG + + + + GT ++APE+ G SF+ DI++ G++LY +++
Sbjct: 220 ---IGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLI 276
Query: 318 GQLPFNSKDMSAIKHEI--NELSF------SPEAMSKLHDSLDLAPID-PSLYNLV 364
G+ PF ++D++ I I + SF S E + D L L PI+ PSL ++
Sbjct: 277 GKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIM 332
>Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 69.7 bits (169), Expect = 9e-12
Identities = 55/187 (29%), Positives = 88/187 (46%), Gaps = 23/187 (12%)
Query: 197 RRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDT 256
RR+ LL K R LT + I G + LH R+IHRDLK N L E+ +
Sbjct: 134 RRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLE---- 189
Query: 257 DKFPKCVIGDFGESQL--YGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYF 314
IGDFG + Y R T GT ++APE+ SF+ D+++ G I+Y
Sbjct: 190 -----VKIGDFGLATKVEYDGERKKT-LCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYT 243
Query: 315 VIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSL 374
+++G+ PF + S +K + + ++ K I+P +L+ +ML P+
Sbjct: 244 LLVGKPPF---ETSCLKETYLRIKKNEYSIPK--------HINPVAASLIQKMLQTDPTA 292
Query: 375 RPDSSQI 381
RP +++
Sbjct: 293 RPTINEL 299
>CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 336
Score = 69.7 bits (169), Expect = 9e-12
Identities = 64/243 (26%), Positives = 108/243 (44%), Gaps = 45/243 (18%)
Query: 140 VESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRK 199
VE L L Q+D +D +T FI+ + + G+L +TI+
Sbjct: 121 VEMLSLIQHDHIISIIDAFSTENQYFIVFEHAQYGDLYETIR------------------ 162
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
K RI I+++ +A+ L LH ++HRD+KP N LL+++F
Sbjct: 163 -----KNGRIEEPDAAIITL--QVASALNYLHERNVVHRDVKPENLLLVDKFSVK----- 210
Query: 260 PKCVIGDFGES-QLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMG 318
+ DFG + + G L G T + APE+ + +S + DI++ G++LY +++G
Sbjct: 211 ----LCDFGLACHILGPLYRICG---TPTYCAPEVLRETGYSTRCDIWSLGVVLYVMLVG 263
Query: 319 QLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDS 378
PF + D + + +A L D + I +LV ++N T RP +
Sbjct: 264 YAPFRAPDQTRL------FKLIMQAKPNL-DMPEWKGISLKAKDLVSRLMNKTEERRPLA 316
Query: 379 SQI 381
SQI
Sbjct: 317 SQI 319
>CE01554 [T] KOG0986 G protein-coupled receptor kinase
Length = 642
Score = 69.7 bits (169), Expect = 9e-12
Identities = 40/125 (32%), Positives = 62/125 (49%), Gaps = 9/125 (7%)
Query: 210 GLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGE 269
G +++ A +I GL+ LHS RI++RDLKP N LL D F I D G
Sbjct: 299 GFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILL---------DDFGHVRISDLGL 349
Query: 270 SQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSA 329
+ G GTV ++APE+ K ++S+ D + G ++Y +I G+ PF +
Sbjct: 350 AVEIKDNEPIKGRVGTVGYMAPEIVKNERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKV 409
Query: 330 IKHEI 334
+ E+
Sbjct: 410 KREEV 414
>YDL101c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 513
Score = 69.3 bits (168), Expect = 1e-11
Identities = 62/212 (29%), Positives = 99/212 (46%), Gaps = 34/212 (16%)
Query: 181 QYQVFNRISGNESRLER--RKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHR 238
+Y V +I E ER RK L +S+ ++ + TGLK LH IIHR
Sbjct: 278 KYLVLEKIDDGEL-FERIVRKTCLRQDESK---------ALFKQLLTGLKYLHEQNIIHR 327
Query: 239 DLKPSNCLL------------LEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTV 286
D+KP N LL L +D + D K I DFG ++ G+++ GT
Sbjct: 328 DIKPENILLNITRRENPSQVQLGPWDEDEIDIQVK--IADFGLAKFTGEMQFTNTLCGTP 385
Query: 287 EFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSK-DMSAIKHEI--NELSFSPEA 343
+VAPE+ ++ K D+++ G+ILY + G PF+ + ++K +I + +F
Sbjct: 386 SYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYSPY 445
Query: 344 MSKLHDSL-----DLAPIDPSLYNLVCEMLNH 370
K+ DS+ +L ++P + E LNH
Sbjct: 446 WDKIDDSVLHLISNLLVLNPDERYNIDEALNH 477
>HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 69.3 bits (168), Expect = 1e-11
Identities = 52/171 (30%), Positives = 78/171 (45%), Gaps = 18/171 (10%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
+T +V + IA G+ LH +IIHRDLK N L+ + D K I DFG S
Sbjct: 208 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYD----DVVK-----ISDFGTS 258
Query: 271 QLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAI 330
+ GTV ++APE+ + S K DI++FG++L+ ++ G++P+ D SAI
Sbjct: 259 KELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI 318
Query: 331 KHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
+ S S D + L+ + N P RP QI
Sbjct: 319 IWGVGSNSLHLPVPSSCPDGFKI---------LLRQCWNSKPRNRPSFRQI 360
>Hs4757868 [T] KOG0193 Serine/threonine protein kinase RAF
Length = 765
Score = 69.3 bits (168), Expect = 1e-11
Identities = 63/227 (27%), Positives = 104/227 (45%), Gaps = 40/227 (17%)
Query: 159 TTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVS 218
+T P + I+ Q+C G +L ++ + E++ E K ++
Sbjct: 519 STKPQLAIVTQWCEGSSL--------YHHLHIIETKFEMIK----------------LID 554
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRD 278
IA A G+ LH+ IIHRDLK +N L E+ D V + S + QL
Sbjct: 555 IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-- 612
Query: 279 ATGSTGTVEFVAPELTKGAQ---FSFKSDIYAFGMILYFVIMGQLPF-NSKDMSAIKHEI 334
+G++ ++APE+ + +SF+SD+YAFG++LY ++ GQLP+ N + I +
Sbjct: 613 ----SGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMV 668
Query: 335 NELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
SP+ +SK+ + A + L+ E L RP QI
Sbjct: 669 GRGYLSPD-LSKVRSNCPKA-----MKRLMAECLKKKRDERPLFPQI 709
>Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 69.3 bits (168), Expect = 1e-11
Identities = 52/171 (30%), Positives = 78/171 (45%), Gaps = 18/171 (10%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
+T +V + IA G+ LH +IIHRDLK N L+ + D K I DFG S
Sbjct: 208 VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYD----DVVK-----ISDFGTS 258
Query: 271 QLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAI 330
+ GTV ++APE+ + S K DI++FG++L+ ++ G++P+ D SAI
Sbjct: 259 KELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI 318
Query: 331 KHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
+ S S D + L+ + N P RP QI
Sbjct: 319 IWGVGSNSLHLPVPSSCPDGFKI---------LLRQCWNSKPRNRPSFRQI 360
>Hs20538863 [T] KOG4250 TANK binding protein kinase TBK1
Length = 756
Score = 69.3 bits (168), Expect = 1e-11
Identities = 48/165 (29%), Positives = 83/165 (50%), Gaps = 30/165 (18%)
Query: 158 PTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIV 217
P +P + ++C+GG+L +K LN ++ GL I+
Sbjct: 88 PNDLP--LLAMEYCQGGDL----------------------RKYLNQFENCCGLREGAIL 123
Query: 218 SIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLR 277
++ +DIA+ L+ LH RIIHRDLKP N ++L++ ++ K I D G ++ Q
Sbjct: 124 TLLSDIASALRYLHENRIIHRDLKPEN-IVLQQGEQRLIHK-----IIDLGYAKELDQGS 177
Query: 278 DATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
T GT++++APEL + +++ D ++FG + + I G PF
Sbjct: 178 LCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPF 222
>Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase
Length = 735
Score = 69.3 bits (168), Expect = 1e-11
Identities = 70/264 (26%), Positives = 111/264 (41%), Gaps = 60/264 (22%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEE 123
F+ + VLG GS V+ V+ + + +A+K L + +V+ R E
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKV---------LKKATLKVRDRVRTKME 112
Query: 124 SSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQ 183
L NH ++ V+ Q +G ++++ F RGG+L
Sbjct: 113 RDILADVNHPFV----VKLHYAFQTEGK------------LYLILDFLRGGDL------- 149
Query: 184 VFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPS 243
F R+S + T + ++A GL LHSL II+RDLKP
Sbjct: 150 -FTRLS-----------------KEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPE 191
Query: 244 NCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQLRDATGSTGTVEFVAPELTKGAQFSFK 302
N LL EE TD FG S + + A GTVE++APE+ S
Sbjct: 192 NILLDEEGHIKLTD---------FGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHS 242
Query: 303 SDIYAFGMILYFVIMGQLPFNSKD 326
+D +++G++++ ++ G LPF KD
Sbjct: 243 ADWWSYGVLMFEMLTGSLPFQGKD 266
Score = 63.2 bits (152), Expect = 8e-10
Identities = 54/196 (27%), Positives = 87/196 (43%), Gaps = 43/196 (21%)
Query: 136 ERCPVESLILTQNDGSSVNM----DIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGN 191
+R P E + + G N+ D+ +++++ + RGG L D I Q F
Sbjct: 453 KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKF------ 506
Query: 192 ESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEF 251
+ R+ + + I ++ LHS ++HRDLKPSN L ++E
Sbjct: 507 -------------------FSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDES 547
Query: 252 DRSDTDKFPKCV-IGDFGESQLYGQLRDATG----STGTVEFVAPELTKGAQFSFKSDIY 306
P+C+ I DFG ++ QLR G T FVAPE+ K + DI+
Sbjct: 548 GN------PECLRICDFGFAK---QLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIW 598
Query: 307 AFGMILYFVIMGQLPF 322
+ G++LY ++ G PF
Sbjct: 599 SLGILLYTMLAGYTPF 614
>At5g50180 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 346
Score = 69.3 bits (168), Expect = 1e-11
Identities = 82/324 (25%), Positives = 132/324 (40%), Gaps = 85/324 (26%)
Query: 70 LGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLY----RCLKEVKLLNRLTEESS 125
+G G+ A VY+ K+ +N+ T A+K + G+ + R L+EV++L+R+ +
Sbjct: 26 IGEGAHAKVYEGKY---KNQ--TVAIKIVHRGETPEEIAKRDSRFLREVEMLSRV--QHK 78
Query: 126 HLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVF 185
+L+ + E P M I+ + +GG L
Sbjct: 79 NLVKFIGACKE-------------------------PVMVIVTELLQGGTL--------- 104
Query: 186 NRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNC 245
RK LLN + + L TR + A DIA G++ LHS IIHRDLKP N
Sbjct: 105 ------------RKYLLNLRPAC--LETRVAIGFALDIARGMECLHSHGIIHRDLKPENL 150
Query: 246 LLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPE--------LTKGA 297
LL T + DFG ++ T TGT ++APE L +
Sbjct: 151 LL--------TADHKTVKLADFGLAREESLTEMMTAETGTYRWMAPELYSTVTLRLGEKK 202
Query: 298 QFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPID 357
++ K D Y+F ++L+ ++ +LPF + + P A S +
Sbjct: 203 HYNHKVDAYSFAIVLWELLHNKLPFEGMSNLQAAYAAAFKNVRPSAES----------LP 252
Query: 358 PSLYNLVCEMLNHTPSLRPDSSQI 381
L ++V N P+ RP+ + I
Sbjct: 253 EELGDIVTSCWNEDPNARPNFTHI 276
>At3g24720 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 297
Score = 69.3 bits (168), Expect = 1e-11
Identities = 46/129 (35%), Positives = 73/129 (55%), Gaps = 10/129 (7%)
Query: 205 KKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLL-LEEFDRSDTDKFPKCV 263
KK R+ L TR+ + IA D A G++ LHS I+H DLK N L+ L + R P C
Sbjct: 112 KKDRL-LDTRKKIIIAMDAAFGMEYLHSKNIVHFDLKCENLLVNLRDPQR------PICK 164
Query: 264 IGDFGESQLYGQLRDATGSTGTVEFVAPELTKGA--QFSFKSDIYAFGMILYFVIMGQLP 321
+GD G S++ + G GT+ ++APEL G+ + S K D++++G+ L+ ++ G+ P
Sbjct: 165 VGDLGLSRIKRNTLVSGGVRGTLPWMAPELLNGSSTRVSEKVDVFSYGISLWEILTGEEP 224
Query: 322 FNSKDMSAI 330
+ AI
Sbjct: 225 YADMHCGAI 233
>At1g54510 [R] KOG0589 Serine/threonine protein kinase
Length = 612
Score = 69.3 bits (168), Expect = 1e-11
Identities = 70/313 (22%), Positives = 123/313 (38%), Gaps = 71/313 (22%)
Query: 70 LGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCL-KEVKLLNRLTEESSHLI 128
+G GS V+H ++E + LKKI + R +E++L++++ ++
Sbjct: 10 IGKGSFGSALLVRH---KHEKKKYVLKKIRLARQTQRTRRSAHQEMELISKMRHP--FIV 64
Query: 129 TYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRI 188
Y W+E+ Y+ I+ +C GG++ I+
Sbjct: 65 EYKDSWVEKAC-----------------------YVCIVIGYCEGGDMAQAIK------- 94
Query: 189 SGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLL 248
K + + ++ + GL+ LHS I+HRD+K SN L
Sbjct: 95 ----------------KSNGVHFQEEKLCKWLVQLLMGLEYLHSNHILHRDVKCSNIFLT 138
Query: 249 EEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAF 308
+E D +GDFG +++ + GT ++ PEL + KSDI++
Sbjct: 139 KEQDIR---------LGDFGLAKILTSDDLTSSVVGTPSYMCPELLADIPYGSKSDIWSL 189
Query: 309 GMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEML 368
G +Y + + F + DM A+ ++IN+ SP A LV ML
Sbjct: 190 GCCIYEMAYLKPAFKAFDMQALINKINKTIVSPLP----------AKYSGPFRGLVKSML 239
Query: 369 NHTPSLRPDSSQI 381
P +RP +S +
Sbjct: 240 RKNPEVRPSASDL 252
>At1g16270_2 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 345
Score = 69.3 bits (168), Expect = 1e-11
Identities = 42/122 (34%), Positives = 71/122 (57%), Gaps = 7/122 (5%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
L R+ + IA D A G++ LH+ I+H DLK N L+ + D + P C +GDFG S
Sbjct: 162 LDRRKRLIIAMDAAFGMEYLHAKNIVHFDLKCDNLLV----NLKDPSR-PICKVGDFGLS 216
Query: 271 QLYGQLRDATGSTGTVEFVAPELTKG--AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMS 328
++ + G GT+ ++APEL G ++ S K D+++FG++L+ ++ G+ P+ +
Sbjct: 217 KIKRNTLVSGGVRGTLPWMAPELLNGSSSKVSEKVDVFSFGIVLWEILTGEEPYANMHYG 276
Query: 329 AI 330
AI
Sbjct: 277 AI 278
>YCL024w [T] KOG0583 Serine/threonine protein kinase
Length = 1037
Score = 68.9 bits (167), Expect = 2e-11
Identities = 39/117 (33%), Positives = 61/117 (51%), Gaps = 10/117 (8%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
L R+ ++ I G+ H+L I+HRDLKP N LL D F I DFG +
Sbjct: 124 LPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLL---------DSFYNIKIADFGMA 174
Query: 271 QLYGQLRDATGSTGTVEFVAPELTKGAQF-SFKSDIYAFGMILYFVIMGQLPFNSKD 326
L S G+ + APE+ G + F SD+++ G+IL+ ++ G+LPF+ ++
Sbjct: 175 ALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEEN 231
>SPAC890.03 [T] KOG0583 Serine/threonine protein kinase
Length = 672
Score = 68.9 bits (167), Expect = 2e-11
Identities = 71/265 (26%), Positives = 121/265 (44%), Gaps = 56/265 (21%)
Query: 124 SSHLITYNHVWLER-CPVESLILTQNDGSSVNM---------DIPTTMPYMFILQQFCRG 173
++HL+T V L+ C +++IL + + ++ T +++ ++C
Sbjct: 48 AAHLLTNTKVVLKSSCRKQAIILAREIHHHRRLLHPNITRLYEVVCTEDRIYLAMEYCPN 107
Query: 174 GNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSL 233
G L D + R+K L+ K TT +I+ + ++ LH
Sbjct: 108 GELYDWVA----------------REKRLDEK------TTCRIMW---QLCCAIQYLHRQ 142
Query: 234 RIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGST--GTVEFVAP 291
+HRDLK N L DK +GDFG S+ R +T GTV + AP
Sbjct: 143 GCVHRDLKLENIFL---------DKAYNVKLGDFGFSRDSDCSRRTFMNTRCGTVAYCAP 193
Query: 292 ELTKGAQFSFKS-DIYAFGMILYFVIMGQLPFNSKDMSAIKHE-INELSFSPEAMSKLHD 349
EL +G ++ + DI++ G+I+Y +++G+LPF+ D+S + + INE PE +SK
Sbjct: 194 ELVQGHKYIGECVDIWSLGIIMYALLIGRLPFDEDDVSLTEQKIINECPQYPETLSKNSS 253
Query: 350 SLDLAPIDPSLYNLVCEMLNHTPSL 374
SL L +L+C+ PS+
Sbjct: 254 SL--------LKSLLCKDYRLRPSI 270
>Hs5453964 [T] KOG0583 Serine/threonine protein kinase
Length = 550
Score = 68.9 bits (167), Expect = 2e-11
Identities = 76/305 (24%), Positives = 124/305 (39%), Gaps = 57/305 (18%)
Query: 80 KVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHLITYNHVWLERCP 139
K+ H +L + LG K+ +G H L VK+LNR S + V R
Sbjct: 14 KIGHYILGDTLGVGTFGKVKVGK--HELTGHKVAVKILNRQKIRSLDV-----VGKIRRE 66
Query: 140 VESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRK 199
+++L L ++ + +T +F++ ++ GG L D I +
Sbjct: 67 IQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYIC----------------KN 110
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
L+ K+SR + I +G+ H ++HRDLKP N LL D
Sbjct: 111 GRLDEKESR---------RLFQQILSGVDYCHRHMVVHRDLKPENVLL---------DAH 152
Query: 260 PKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSF-KSDIYAFGMILYFVIMG 318
I DFG S + S G+ + APE+ G ++ + DI++ G+ILY ++ G
Sbjct: 153 MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCG 212
Query: 319 QLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAP--IDPSLYNLVCEMLNHTPSLRP 376
LPF+ + P K+ D + P ++PS+ +L+ ML P R
Sbjct: 213 TLPFDDDHV-------------PTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRA 259
Query: 377 DSSQI 381
I
Sbjct: 260 SIKDI 264
>CE28819 [T] KOG1095 Protein tyrosine kinase
Length = 2364
Score = 68.9 bits (167), Expect = 2e-11
Identities = 58/216 (26%), Positives = 96/216 (43%), Gaps = 29/216 (13%)
Query: 131 NHVWLERCPV--ESLILTQNDGSSV--NMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFN 186
NH + E+ E+++L D ++ + + T IL ++ GGNL +Q N
Sbjct: 1889 NHSFQEKMMFMKEAILLNNLDHPNIVKELGVCITPGQELILLEYMEGGNLLKFLQKSTPN 1948
Query: 187 RISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCL 246
+E L+ R ++SI+ DIA G+ L L +H++L CL
Sbjct: 1949 EYQSSE------------------LSPRDLLSISVDIARGMNYLERLPHVHKNLSARKCL 1990
Query: 247 LLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIY 306
L R K + + Q+ R + V ++APE+ K QFS KSD++
Sbjct: 1991 LA---GRPGVTKLEMGMSKELSNGQVN---RSDLENMEIVRWMAPEVLKDFQFSSKSDVW 2044
Query: 307 AFGMILYFVI-MGQLPFNSKDMSAIKHEINELSFSP 341
A+G++LY V G++P+ KD I ++ S P
Sbjct: 2045 AYGVLLYEVFSFGEVPYGDKDNRRIMTDVRNGSVLP 2080
>SPCC63.08c [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 830
Score = 68.6 bits (166), Expect = 2e-11
Identities = 76/321 (23%), Positives = 132/321 (40%), Gaps = 56/321 (17%)
Query: 70 LGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHLIT 129
+G GS A+VYK KH + ++K + L + L + KLL L E S L
Sbjct: 20 IGRGSFAIVYKGKHTETNRVI---SIKSV--------LTKKLTK-KLLENLESEISILKE 67
Query: 130 YNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRIS 189
HV + +D ++ ++ ++C G+L Y + R
Sbjct: 68 IRHVHVVEL----------------IDCIKAGRFIHLVMEYCSLGDLS----YFIRKREK 107
Query: 190 GNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLL-- 247
N + + + GL + +A+ L+ L S +IHRD+KP N LL
Sbjct: 108 FNSIPSLAWINIDHPPVYKAGLNETLVRHFTQQLASALQFLRSRSLIHRDVKPQNLLLQP 167
Query: 248 ------LEEFDRS-DTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFS 300
LEE + + K P + DFG ++ A G+ ++APE+ + ++
Sbjct: 168 PPTAAYLEEHPQFVGSPKLPMLKLADFGFARYLQTSSMAETLCGSPLYMAPEILRYEKYD 227
Query: 301 FKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINE----LSFSPEAMSKLHDSLDLAPI 356
K+D+++ G +LY + +G+ PF + + + I + + F EA I
Sbjct: 228 AKADLWSVGAVLYEMAVGKPPFKAPNHVELLRRIQKAKDVIKFPEEAF-----------I 276
Query: 357 DPSLYNLVCEMLNHTPSLRPD 377
P + L+C +L P+ R D
Sbjct: 277 HPDIKTLICALLKQNPADRID 297
>Hs5453976 [T] KOG0694 Serine/threonine protein kinase
Length = 706
Score = 68.6 bits (166), Expect = 2e-11
Identities = 46/130 (35%), Positives = 71/130 (54%), Gaps = 13/130 (10%)
Query: 220 ANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDA 279
A +I GL+ LHS I++RDLK N LL DK I DFG + L DA
Sbjct: 485 AAEIILGLQFLHSKGIVYRDLKLDNILL---------DKDGHIKIADFGMCK-ENMLGDA 534
Query: 280 TGST--GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEIN-E 336
+T GT +++APE+ G +++ D ++FG++LY +++GQ PF+ +D + H I +
Sbjct: 535 KTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMD 594
Query: 337 LSFSPEAMSK 346
F P + K
Sbjct: 595 NPFYPRWLEK 604
>At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 648
Score = 68.6 bits (166), Expect = 2e-11
Identities = 73/289 (25%), Positives = 122/289 (41%), Gaps = 65/289 (22%)
Query: 70 LGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHLIT 129
+G+GS AVV+ KH E+ A+K+I + L K+ + L +E S L T
Sbjct: 16 IGSGSFAVVWLAKHRSSGLEV---AVKEID---------KKLLSPKVRDNLLKEISILST 63
Query: 130 YNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRIS 189
+H + R + T +F++ ++C GG+L I
Sbjct: 64 IDHPNIIRF----------------YEAIETGDRIFLVLEYCSGGDLAGYI--------- 98
Query: 190 GNESRLERRKKLLNHKKSRIGLTTRQIVS-IANDIATGLKQLHSLRIIHRDLKPSNCLLL 248
+R G + +A GL+ L IHRDLKP N LL
Sbjct: 99 -----------------NRHGKVPEAVAKHFMRQLALGLQVLQEKHFIHRDLKPQNLLL- 140
Query: 249 EEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAF 308
S + P IGDFG ++ A G+ ++APE+ + ++ K+D+++
Sbjct: 141 -----SSKEVTPLLKIGDFGFARSLTPESMAETFCGSPLYMAPEIIRNQKYDAKADLWSA 195
Query: 309 GMILYFVIMGQLPFNSKDMSAIKHEI---NELSFSPEAMSKLH-DSLDL 353
G IL+ ++ G+ PF+ + + H I EL F + +++H D +DL
Sbjct: 196 GAILFQLVTGKPPFDGNNHIQLFHNIVRDTELKFPEDTRNEIHPDCVDL 244
>At1g04700_2 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 333
Score = 68.6 bits (166), Expect = 2e-11
Identities = 47/160 (29%), Positives = 83/160 (51%), Gaps = 19/160 (11%)
Query: 173 GGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHS 232
GG + +Y V + L+R+ +LL+ +K + I D A G++ LH
Sbjct: 132 GGTMATVTEYMVNGSL---RHVLQRKDRLLDRRKK---------LMITLDSAFGMEYLHM 179
Query: 233 LRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPE 292
I+H DLK N L+ + D + P C +GDFG S++ + G GT+ ++APE
Sbjct: 180 KNIVHFDLKCDNLLV----NLRDPQR-PICKVGDFGLSRIKRNTLVSGGVRGTLPWMAPE 234
Query: 293 LTKGA--QFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAI 330
L G+ + S K D+++FG++++ ++ G+ P+ + AI
Sbjct: 235 LLNGSSNRVSEKVDVFSFGIVMWEILTGEEPYANLHCGAI 274
>YDR122w [T] KOG0583 Serine/threonine protein kinase
Length = 1064
Score = 68.2 bits (165), Expect = 3e-11
Identities = 44/156 (28%), Positives = 79/156 (50%), Gaps = 18/156 (11%)
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
Y +F +SG + LL++ + Q A IA+ L LH+ I+HRDLK
Sbjct: 220 YMLFEYVSGGQ--------LLDYIIQHGSIREHQARKFARGIASALIYLHANNIVHRDLK 271
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSF 301
N ++ SD+ + I DFG S +Y + G++ F APEL K ++
Sbjct: 272 IENIMI------SDSSEIK---IIDFGLSNIYDSRKQLHTFCGSLYFAAPELLKANPYTG 322
Query: 302 KS-DIYAFGMILYFVIMGQLPFNSKDMSAIKHEINE 336
D+++FG++L+ ++ G++PF+ ++ S + +I +
Sbjct: 323 PEVDVWSFGVVLFVLVCGKVPFDDENSSVLHEKIKQ 358
>Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 878
Score = 68.2 bits (165), Expect = 3e-11
Identities = 73/305 (23%), Positives = 121/305 (38%), Gaps = 64/305 (20%)
Query: 47 NSRIPEDIFVQGYYQRFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHW 106
NS+I E++ + YQ F +V LG+G VVY KH ++ + K+
Sbjct: 536 NSQIQENVDIATVYQIFPDEV--LGSGQFGVVYGGKHRKTGRDVAVKVIDKLRF------ 587
Query: 107 LYRCLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPY-MF 165
K ++L E + L + H + VN++ P +F
Sbjct: 588 ------PTKQESQLRNEVAILQSLRHPGI-----------------VNLECMFETPEKVF 624
Query: 166 ILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIAT 225
++ + G LE +L+ +K R L R + I
Sbjct: 625 VVMEKLHGDMLE----------------------MILSSEKGR--LPERLTKFLITQILV 660
Query: 226 GLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGT 285
L+ LH I+H DLKP N LL + D FP+ + DFG +++ G+ GT
Sbjct: 661 ALRHLHFKNIVHCDLKPENVLL------ASADPFPQVKLCDFGFARIIGEKSFRRSVVGT 714
Query: 286 VEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMS 345
++APE+ ++ D+++ G+I+Y + G PFN + I +I +F A
Sbjct: 715 PAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDE--DINDQIQNAAFMYPASP 772
Query: 346 KLHDS 350
H S
Sbjct: 773 WSHIS 777
>At4g38470 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 545
Score = 68.2 bits (165), Expect = 3e-11
Identities = 57/227 (25%), Positives = 96/227 (42%), Gaps = 60/227 (26%)
Query: 159 TTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVS 218
T P++ I+ +F GG++ D L+ +K L T +
Sbjct: 343 TKPPHLCIVTEFMPGGSVYD----------------------YLHKQKGVFKLPT--LFK 378
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRD 278
+A DI G+ LH IIHRDLK +N L+ D ++ K + DFG +++ Q
Sbjct: 379 VAIDICKGMSYLHQNNIIHRDLKAANLLM----DENEVVK-----VADFGVARVKAQTGV 429
Query: 279 ATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELS 338
T TGT ++APE+ + + K+D++++G++L+ ++ G+
Sbjct: 430 MTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWELLTGK------------------G 471
Query: 339 FSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQIEYQL 385
P H P L L+ + H + RPD S+I QL
Sbjct: 472 LRPTIPKNTH---------PKLAELLERLWEHDSTQRPDFSEIIEQL 509
>7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 835
Score = 68.2 bits (165), Expect = 3e-11
Identities = 65/279 (23%), Positives = 117/279 (41%), Gaps = 58/279 (20%)
Query: 56 VQGYYQRFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVK 115
+ G Y+ + +LG+G+ AVVYK +H + A+K I + KE+K
Sbjct: 3 IVGEYE--YSSKDMLGHGAFAVVYKGRHRKKHMPV---AIKCITKKGQLKTQNLLGKEIK 57
Query: 116 LLNRLTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGN 175
+L LTE ++ +D + + ++ ++C GG+
Sbjct: 58 ILKELTE-----------------------LHHENVVALLDCKESQDCVSLVMEYCNGGD 94
Query: 176 LEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRI 235
L D + K L+ R+ L +A +K L++ I
Sbjct: 95 LADYLSV----------------KGTLSEDTVRLFLV---------QLAGAMKALYTKGI 129
Query: 236 IHRDLKPSNCLLLEEFDRSDTDKFPKCV---IGDFGESQLYGQLRDATGSTGTVEFVAPE 292
+HRDLKP N LL + + T P + I DFG ++ + A G+ ++APE
Sbjct: 130 VHRDLKPQNILLSHNYGK--TLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPE 187
Query: 293 LTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIK 331
+ Q+ K+D+++ G I+Y + G+ PF ++ + +K
Sbjct: 188 VIMSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELK 226
>Hs4826684_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 370
Score = 68.2 bits (165), Expect = 3e-11
Identities = 53/188 (28%), Positives = 84/188 (44%), Gaps = 13/188 (6%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
+L + + LT + I G+ LHSL+I H DLKP N +LL DR+
Sbjct: 100 ELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL---DRNVPK-- 154
Query: 260 PKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQ 319
P+ I DFG + + GT EFVAPE+ ++D+++ G+I Y ++ G
Sbjct: 155 PRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGA 214
Query: 320 LPF-------NSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTP 372
PF ++SA+ +E + FS + L DP + + L H P
Sbjct: 215 SPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQH-P 273
Query: 373 SLRPDSSQ 380
++P +Q
Sbjct: 274 WIKPKDTQ 281
>Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 890
Score = 67.8 bits (164), Expect = 3e-11
Identities = 69/281 (24%), Positives = 118/281 (41%), Gaps = 62/281 (22%)
Query: 47 NSRIPEDIFVQGYYQRFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHW 106
N +I E++ + YQ F +V LG+G +VY KH ++ A+K I D M +
Sbjct: 561 NCQIQENVDISTVYQIFADEV--LGSGQFGIVYGGKHRKTGRDV---AIKVI---DKMRF 612
Query: 107 LYRCLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPY-MF 165
K ++L E + L +H + VN++ P +F
Sbjct: 613 ------PTKQESQLRNEVAILQNLHHPGI-----------------VNLECMFETPERVF 649
Query: 166 ILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIAT 225
++ + G LE +L+ +KSR L R + I
Sbjct: 650 VVMEKLHGDMLE----------------------MILSSEKSR--LPERITKFMVTQILV 685
Query: 226 GLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGT 285
L+ LH I+H DLKP N LL + + FP+ + DFG +++ G+ GT
Sbjct: 686 ALRNLHFKNIVHCDLKPENVLL------ASAEPFPQVKLCDFGFARIIGEKSFRRSVVGT 739
Query: 286 VEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKD 326
++APE+ + ++ D+++ G+I+Y + G PFN +
Sbjct: 740 PAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE 780
>Hs14916455 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 385
Score = 67.8 bits (164), Expect = 3e-11
Identities = 42/125 (33%), Positives = 67/125 (53%), Gaps = 8/125 (6%)
Query: 212 TTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQ 271
T R V I +A G++ LH+L+I HR+LKP N L + S K +I DFG +
Sbjct: 156 TERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEES------KILITDFGLAY 209
Query: 272 LYGQLRDATGST--GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSA 329
+ D T T GT E++APE+ ++ D++A G+I Y ++ G LPF+ + +
Sbjct: 210 SGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDESQTR 269
Query: 330 IKHEI 334
+ +I
Sbjct: 270 LYRKI 274
>CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 856
Score = 67.8 bits (164), Expect = 3e-11
Identities = 69/266 (25%), Positives = 116/266 (42%), Gaps = 55/266 (20%)
Query: 69 VLGNGSRAVVYKVKHM-LLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHL 127
+LG+G+ A+VY+ +++ + + A+ K I + L KE+K+L L S L
Sbjct: 14 LLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSKNLL---TKEIKILKEL----SSL 66
Query: 128 ITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNR 187
N V L +C + PT +++++ +FC GG+L D +Q
Sbjct: 67 KHENLVGLLKCT----------------ETPT---HVYLVMEFCNGGDLADYLQ------ 101
Query: 188 ISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLL 247
+K LN I IA L+ ++ I+HRDLKP N LL
Sbjct: 102 ----------QKTTLNEDT---------IQHFVVQIAHALEAINKKGIVHRDLKPQNILL 142
Query: 248 LEEFDRSDTDKFPKCVI--GDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDI 305
R+ F VI DFG ++ A G+ ++APE+ Q+ K+D+
Sbjct: 143 CNN-SRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAPEVIMSMQYDAKADL 201
Query: 306 YAFGMILYFVIMGQLPFNSKDMSAIK 331
++ G IL+ + G+ PF ++ +K
Sbjct: 202 WSIGTILFQCLTGKAPFVAQTPPQLK 227
>CE17354 [T] KOG0694 Serine/threonine protein kinase
Length = 567
Score = 67.8 bits (164), Expect = 3e-11
Identities = 65/275 (23%), Positives = 119/275 (42%), Gaps = 51/275 (18%)
Query: 79 YKVKHMLLENELGTFALKKICI----GDDMHWLYRCLKEVKLLNRLTEESSHLITYNHVW 134
+ + H L LG + K+ + G + + +CLK+ +L E +++ +
Sbjct: 233 FALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLIL 292
Query: 135 LERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESR 194
+CP + T Y+F + ++ GG+L IQ
Sbjct: 293 ASQCPFLCQLFCSFQ----------TNEYLFFVMEYLNGGDLMHHIQ------------- 329
Query: 195 LERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRS 254
+ K + ++R A +I L+ LH+ II+RDLK N LL
Sbjct: 330 ---QIKKFDEARTRF---------YACEIVVALQFLHTNNIIYRDLKLDNVLL------- 370
Query: 255 DTDKFPKCVIGDFGESQLYGQLRDATGST--GTVEFVAPELTKGAQFSFKSDIYAFGMIL 312
D D K + DFG ++ + ST GT ++++PE+ KG ++ D ++FG+++
Sbjct: 371 DCDGHIK--LADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLM 428
Query: 313 YFVIMGQLPFNSKDMSAIKHEI-NELSFSPEAMSK 346
Y +++GQ PF+ + + I NE + P+ +SK
Sbjct: 429 YEMLVGQSPFHGEGEDELFDSILNERPYFPKTISK 463
>CE17353 [T] KOG0694 Serine/threonine protein kinase
Length = 704
Score = 67.8 bits (164), Expect = 3e-11
Identities = 65/275 (23%), Positives = 119/275 (42%), Gaps = 51/275 (18%)
Query: 79 YKVKHMLLENELGTFALKKICI----GDDMHWLYRCLKEVKLLNRLTEESSHLITYNHVW 134
+ + H L LG + K+ + G + + +CLK+ +L E +++ +
Sbjct: 370 FALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLIL 429
Query: 135 LERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESR 194
+CP + T Y+F + ++ GG+L IQ
Sbjct: 430 ASQCPFLCQLFCSFQ----------TNEYLFFVMEYLNGGDLMHHIQ------------- 466
Query: 195 LERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRS 254
+ K + ++R A +I L+ LH+ II+RDLK N LL
Sbjct: 467 ---QIKKFDEARTRF---------YACEIVVALQFLHTNNIIYRDLKLDNVLL------- 507
Query: 255 DTDKFPKCVIGDFGESQLYGQLRDATGST--GTVEFVAPELTKGAQFSFKSDIYAFGMIL 312
D D K + DFG ++ + ST GT ++++PE+ KG ++ D ++FG+++
Sbjct: 508 DCDGHIK--LADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLM 565
Query: 313 YFVIMGQLPFNSKDMSAIKHEI-NELSFSPEAMSK 346
Y +++GQ PF+ + + I NE + P+ +SK
Sbjct: 566 YEMLVGQSPFHGEGEDELFDSILNERPYFPKTISK 600
>At3g04810 [R] KOG0589 Serine/threonine protein kinase
Length = 606
Score = 67.8 bits (164), Expect = 3e-11
Identities = 69/314 (21%), Positives = 126/314 (39%), Gaps = 73/314 (23%)
Query: 70 LGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCL-KEVKLLNRLTEESSHLI 128
+G GS V+H ++E + LKKI + R +E++L++++ + ++
Sbjct: 10 IGKGSFGSALLVRH---KHEKKLYVLKKIRLARQTGRTRRSAHQEMELISKI--HNPFIV 64
Query: 129 TYNHVWLER-CPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNR 187
Y W+E+ C Y+ I+ +C+GG++ + I+
Sbjct: 65 EYKDSWVEKGC------------------------YVCIIIGYCKGGDMAEAIK------ 94
Query: 188 ISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLL 247
K + + T ++ I L+ LH+ I+HRD+K SN L
Sbjct: 95 -----------------KTNGVHFTEEKLCKWLVQILLALEYLHANHILHRDVKCSNIFL 137
Query: 248 LEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYA 307
++ D +GDFG +++ A+ GT ++ PEL + KSDI++
Sbjct: 138 TKDQDIR---------LGDFGLAKVLTSDDLASSVVGTPSYMCPELLADIPYGSKSDIWS 188
Query: 308 FGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEM 367
G +Y + + F + DM + + IN P A + LV M
Sbjct: 189 LGCCMYEMTAMKPAFKAFDMQGLINRINRSIVPPLP----------AQYSAAFRGLVKSM 238
Query: 368 LNHTPSLRPDSSQI 381
L P LRP ++++
Sbjct: 239 LRKNPELRPSAAEL 252
>SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase
Length = 891
Score = 67.4 bits (163), Expect = 4e-11
Identities = 45/156 (28%), Positives = 76/156 (47%), Gaps = 18/156 (11%)
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
Y VF + G + +L++ S L +Q I + L LH ++HRDLK
Sbjct: 217 YMVFEFVDGGQ--------MLDYIISHGKLKEKQARKFVRQIGSALSYLHQNSVVHRDLK 268
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQF-S 300
N L+ + D I DFG S LY + G++ F APEL +
Sbjct: 269 IENILISKTGDIK---------IIDFGLSNLYRRQSRLRTFCGSLYFAAPELLNAQPYIG 319
Query: 301 FKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINE 336
+ D+++FG++LY ++ G++PF+ ++MSA+ +I +
Sbjct: 320 PEVDVWSFGIVLYVLVCGKVPFDDQNMSALHAKIKK 355
>HsM4758892 [J] KOG1033 eIF-2alpha kinase PEK/EIF2AK3
Length = 1115
Score = 67.4 bits (163), Expect = 4e-11
Identities = 71/255 (27%), Positives = 107/255 (41%), Gaps = 62/255 (24%)
Query: 142 SLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKL 201
SL LT+N + P Y++I Q CR NL+D + +G + ER + +
Sbjct: 863 SLDLTKNTTEKLQPSSPKV--YLYIQMQLCRKENLKDWM--------NGRCTIEERERSV 912
Query: 202 LNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPK 261
H I IA ++ LHS ++HRDLKPSN F D K
Sbjct: 913 CLH--------------IFLQIAEAVEFLHSKGLMHRDLKPSNIF----FTMDDVVK--- 951
Query: 262 CVIGDFGESQLYGQLRDA-------------TGSTGTVEFVAPELTKGAQFSFKSDIYAF 308
+GDFG Q + TG GT +++PE G +S K DI++
Sbjct: 952 --VGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSL 1009
Query: 309 GMILYFVIMGQLPFNSKDMSAIK--HEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCE 366
G+IL+ ++ PF S M ++ ++ L F P K P Y +V +
Sbjct: 1010 GLILFELL---YPF-STQMERVRTLTDVRNLKFPPLFTQKY----------PCEYVMVQD 1055
Query: 367 MLNHTPSLRPDSSQI 381
ML+ +P RP++ I
Sbjct: 1056 MLSPSPMERPEAINI 1070
>Hs7705748 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 835
Score = 67.4 bits (163), Expect = 4e-11
Identities = 45/155 (29%), Positives = 83/155 (53%), Gaps = 20/155 (12%)
Query: 173 GGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHS 232
G L D Q+ + + S LL+ +K + L ++ I+++ D+A G++ LH+
Sbjct: 526 GACLNDPSQFAIVTQYISGGSLFS----LLHEQKRILDLQSKLIIAV--DVAKGMEYLHN 579
Query: 233 LR--IIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRD--ATGSTGTVEF 288
L IIHRDL N LL E+ V+ DFGES+ L + T G + +
Sbjct: 580 LTQPIIHRDLNSHNILLYED---------GHAVVADFGESRFLQSLDEDNMTKQPGNLRW 630
Query: 289 VAPEL-TKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
+APE+ T+ +++ K+D++++ + L+ ++ G++PF
Sbjct: 631 MAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPF 665
>Hs4506401 [T] KOG0193 Serine/threonine protein kinase RAF
Length = 648
Score = 67.4 bits (163), Expect = 4e-11
Identities = 54/176 (30%), Positives = 89/176 (49%), Gaps = 26/176 (14%)
Query: 215 QIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQL-- 272
Q++ IA A G+ LH+ IIHRD+K +N L E IGDFG + +
Sbjct: 444 QLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVK---------IGDFGLATVKS 494
Query: 273 -YGQLRDATGSTGTVEFVAPELTK---GAQFSFKSDIYAFGMILYFVIMGQLPF---NSK 325
+ + TG+V ++APE+ + FSF+SD+Y++G++LY ++ G+LP+ N++
Sbjct: 495 RWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNR 554
Query: 326 DMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
D I + SP+ +SKL+ + A + LV + + RP QI
Sbjct: 555 DQ--IIFMVGRGYASPD-LSKLYKNCPKA-----MKRLVADCVKKVKEERPLFPQI 602
>Hs21361155 [J] KOG1033 eIF-2alpha kinase PEK/EIF2AK3
Length = 1115
Score = 67.4 bits (163), Expect = 4e-11
Identities = 71/255 (27%), Positives = 107/255 (41%), Gaps = 62/255 (24%)
Query: 142 SLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKL 201
SL LT+N + P Y++I Q CR NL+D + +G + ER + +
Sbjct: 863 SLDLTKNTTEKLQPSSPKV--YLYIQMQLCRKENLKDWM--------NGRCTIEERERSV 912
Query: 202 LNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPK 261
H I IA ++ LHS ++HRDLKPSN F D K
Sbjct: 913 CLH--------------IFLQIAEAVEFLHSKGLMHRDLKPSNIF----FTMDDVVK--- 951
Query: 262 CVIGDFGESQLYGQLRDA-------------TGSTGTVEFVAPELTKGAQFSFKSDIYAF 308
+GDFG Q + TG GT +++PE G +S K DI++
Sbjct: 952 --VGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSL 1009
Query: 309 GMILYFVIMGQLPFNSKDMSAIK--HEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCE 366
G+IL+ ++ PF S M ++ ++ L F P K P Y +V +
Sbjct: 1010 GLILFELL---YPF-STQMERVRTLTDVRNLKFPPLFTQKY----------PCEYVMVQD 1055
Query: 367 MLNHTPSLRPDSSQI 381
ML+ +P RP++ I
Sbjct: 1056 MLSPSPMERPEAINI 1070
>Hs14776113 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 424
Score = 67.4 bits (163), Expect = 4e-11
Identities = 48/168 (28%), Positives = 77/168 (45%), Gaps = 15/168 (8%)
Query: 212 TTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQ 271
T R + + G++ LH+L I HRDLKP N L + TD K +I DFG +
Sbjct: 191 TERDATRVLQMVLDGVRYLHALGITHRDLKPENLL----YYHPGTDS--KIIITDFGLAS 244
Query: 272 LYGQLRDATGST--GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSA 329
+ D T GT E++APE+ ++ D++A G+I Y ++ G +PF + +
Sbjct: 245 ARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTR 304
Query: 330 IKHEINELSFS------PEAMSKLHDSLD-LAPIDPSLYNLVCEMLNH 370
+ +I +S P + D +D L +DP + L H
Sbjct: 305 LYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRH 352
>At5g55560 [R] KOG0584 Serine/threonine protein kinase
Length = 313
Score = 67.4 bits (163), Expect = 4e-11
Identities = 75/316 (23%), Positives = 129/316 (40%), Gaps = 69/316 (21%)
Query: 62 RFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLT 121
R+ + +LG+G+ VY+ E+ +K C DD R EV+LL L
Sbjct: 28 RYGRYGELLGSGAVKKVYRAFDQEEGIEVAWNQVKLRCFSDDPAMTERLYSEVRLLKNL- 86
Query: 122 EESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQ 181
++S++IT VW + +++N + + C GNL +
Sbjct: 87 -KNSNIITLYKVWRDE-----------RNNTLNF-----------ITEICTSGNLRE--- 120
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLR--IIHRD 239
++K ++ R + + I GL LH+ IIHRD
Sbjct: 121 ----------------------YRKKHRHVSMRALKKWSKQILKGLDYLHTHDPCIIHRD 158
Query: 240 LKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQF 299
L SN + + IGD G + + G+ A GT EF+APEL + +
Sbjct: 159 LNCSNIFV--------NGNIGQVKIGDLGLAAIVGKNHLAHSILGTPEFMAPELYE-ENY 209
Query: 300 SFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPID-- 357
+ DIY++GM + ++ ++P++ D A ++ PEA++K++D A I+
Sbjct: 210 TEMVDIYSYGMCVLELVSLEIPYSECDSVAKIYKRVSKGLKPEALNKVNDPEAKAFIEKC 269
Query: 358 -------PSLYNLVCE 366
PS L+C+
Sbjct: 270 IAQPRARPSAAELLCD 285
>At3g11870 [T] KOG1027 Serine/threonine protein kinase and endoribonuclease
ERN1/IRE1 sensor of the unfolded protein response
pathway
Length = 554
Score = 67.4 bits (163), Expect = 4e-11
Identities = 54/193 (27%), Positives = 94/193 (47%), Gaps = 23/193 (11%)
Query: 194 RLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDR 253
++ +R K K + LT ++ + D+ GL LH L+ IHR+L P N L++ + D
Sbjct: 228 KVMKRIKFWKEKGKPLPLTP--MLKLMRDVVCGLAHLHKLKTIHRNLNPQNVLIIVK-DM 284
Query: 254 SDTDKFPKCVIGDF--GESQLYGQLRDATGSTGTVEFVAPE---LTKGAQFSFKSDIYAF 308
+ T K + G+ Y L +GS+G + APE K + F +D++ F
Sbjct: 285 TLTAKISDMSLSKHLGGKKSSYKHLATCSGSSG---WQAPEQLNKDKKKKEDFPADMFNF 341
Query: 309 GMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEML 368
G +L++ +MG PF S +E + + +K + SL + NL+ ++L
Sbjct: 342 GCLLHYAVMGTHPFGSP---------SERDTNIKTNNKTNLSL---VTNLEAINLIEQLL 389
Query: 369 NHTPSLRPDSSQI 381
N+ P LRP ++Q+
Sbjct: 390 NYKPDLRPSATQV 402
>At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 546
Score = 67.4 bits (163), Expect = 4e-11
Identities = 32/117 (27%), Positives = 65/117 (55%), Gaps = 9/117 (7%)
Query: 206 KSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIG 265
K + + ++ +A D+A G+ LH IIHRDLK +N L+ D+ +
Sbjct: 374 KQKCAFKLQTLLKVALDVAKGMSYLHQNNIIHRDLKTANLLM---------DEHGLVKVA 424
Query: 266 DFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
DFG +++ + T TGT ++APE+ + ++ K+D++++ ++L+ ++ G +P+
Sbjct: 425 DFGVARVQIESGVMTAETGTYRWMAPEVIEHKPYNHKADVFSYAIVLWELLTGDIPY 481
>7290147 [T] KOG0583 Serine/threonine protein kinase
Length = 291
Score = 67.4 bits (163), Expect = 4e-11
Identities = 47/164 (28%), Positives = 81/164 (48%), Gaps = 19/164 (11%)
Query: 210 GLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGE 269
G+ +++ D+ GL+ LH +IHRD+KP N LL D +D K I DFG
Sbjct: 108 GVNQERLMGYFRDMVVGLEYLHIRCVIHRDIKPENMLL----DANDRVK-----IADFGI 158
Query: 270 SQLYGQLRDATGSTGTVEFVAPE-LTKGAQFSFKSDIYAFGMILYFVIMGQLPF----NS 324
+ ++ GT ++APE ++ + FKSD+++ G++LY + +G+ PF +
Sbjct: 159 ANVHAPSTQLQAGMGTPMYMAPEAMSSQGKVDFKSDVWSLGLVLYELCLGRSPFAAFLDK 218
Query: 325 KDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEML 368
A+ H + + P +L L DP ++ VCE++
Sbjct: 219 NATPALLHTVVQALVRPRLDCQLIRRL----YDP-VWAQVCELM 257
>YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 508
Score = 67.0 bits (162), Expect = 6e-11
Identities = 72/264 (27%), Positives = 121/264 (45%), Gaps = 59/264 (22%)
Query: 67 VGVLGNGSRAVVYKVKHMLLENELGTFALKKI-CIGDDMHWLYRCLKEVKLLNRLTEESS 125
+G+LG G+ V K K L+N FALK I + D + + +E++ NR + +S
Sbjct: 224 LGILGEGAGGSVSKCK---LKNGSKIFALKVINTLNTDPEYQKQIFRELQF-NR-SFQSE 278
Query: 126 HLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVF 185
+++ Y ++ T ++ SS+ + M YM GG D I
Sbjct: 279 YIVRYYGMF-----------TDDENSSIYI----AMEYM--------GGRSLDAIY---- 311
Query: 186 NRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNC 245
++ LER ++ + + + IA + GL LH ++IHRD+KP N
Sbjct: 312 ------KNLLERGGRI----------SEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNI 355
Query: 246 LLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDI 305
LL ++ + C G GE+ L AT TGT ++APE +G +S SD+
Sbjct: 356 LL------NENGQVKLCDFGVSGEA--VNSL--ATTFTGTSFYMAPERIQGQPYSVTSDV 405
Query: 306 YAFGMILYFVIMGQLPFNSKDMSA 329
++ G+ + V G+ P +S+ M+A
Sbjct: 406 WSLGLTILEVANGKFPCSSEKMAA 429
>YDR507c [D] KOG0588 Serine/threonine protein kinase
Length = 1142
Score = 67.0 bits (162), Expect = 6e-11
Identities = 40/128 (31%), Positives = 66/128 (51%), Gaps = 10/128 (7%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
+L N R L + + I G+ H+L I+HRDLKP N LL +++
Sbjct: 117 ELFNLLVERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYN------- 169
Query: 260 PKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQF-SFKSDIYAFGMILYFVIMG 318
I DFG + L + + S G+ + APE+ G + F SD+++ G+IL+ ++ G
Sbjct: 170 --IKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTG 227
Query: 319 QLPFNSKD 326
+LPF+ +D
Sbjct: 228 RLPFDEED 235
>HsM4507279 [D] KOG0580 Serine/threonine protein kinase
Length = 402
Score = 67.0 bits (162), Expect = 6e-11
Identities = 44/164 (26%), Positives = 78/164 (46%), Gaps = 23/164 (14%)
Query: 214 RQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY 273
++ ++ N IA L HS R+IHRD+KP N LL + I DFG S ++
Sbjct: 230 QRTANLYNRIANALSYCHSKRVIHRDIKPENLLL---------GSAGELKIADFGWS-VH 279
Query: 274 GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHE 333
T GT++++ PE+ +G K D+++ G++ Y ++G+ PF +
Sbjct: 280 APSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKR 339
Query: 334 INELSFS-PEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRP 376
I+ + F+ P+ +++ +L+ +L H PS RP
Sbjct: 340 ISRVEFTFPDFVTE------------GARDLISRLLKHNPSQRP 371
>Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 912
Score = 67.0 bits (162), Expect = 6e-11
Identities = 37/136 (27%), Positives = 68/136 (49%), Gaps = 7/136 (5%)
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRD 278
+ I L+ LH I+H DLKP N LL + D FP+ + DFG +++ G+
Sbjct: 686 LITQILVALRHLHFKNIVHCDLKPENVLL------ASADPFPQVKLCDFGFARIIGEKSF 739
Query: 279 ATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELS 338
GT ++APE+ + ++ D+++ G+I+Y + G PFN + + +
Sbjct: 740 RRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFM 799
Query: 339 FSPEAMSKL-HDSLDL 353
+ P ++ H+++DL
Sbjct: 800 YPPNPWKEISHEAIDL 815
>CE23001 [R] KOG0589 Serine/threonine protein kinase
Length = 579
Score = 67.0 bits (162), Expect = 6e-11
Identities = 48/173 (27%), Positives = 80/173 (45%), Gaps = 22/173 (12%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
L QI + + + + LH ++HRDLK +N L D F K IGDFG S
Sbjct: 266 LDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTR-------DSFVK--IGDFGIS 316
Query: 271 QLYGQLRDATGS---TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDM 327
++ G A G+ GT +++PE+ G ++ KSD++A G ILY + + F ++
Sbjct: 317 KIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCLKKAFEGDNL 376
Query: 328 SAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQ 380
A+ + I +++P P + ++ E+L P RP + Q
Sbjct: 377 PALVNSIMTCAYTPVK----------GPYSAEMKMVIRELLQLDPQKRPSAPQ 419
>At5g28290 [R] KOG0589 Serine/threonine protein kinase
Length = 568
Score = 67.0 bits (162), Expect = 6e-11
Identities = 68/314 (21%), Positives = 127/314 (39%), Gaps = 73/314 (23%)
Query: 70 LGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCL-KEVKLLNRLTEESSHLI 128
+G GS V+H ++E + LKKI + R +E++L++++ + ++
Sbjct: 10 IGKGSFGSALLVRH---KHEKKLYVLKKIRLARQTGRTRRSAHQEMELISKI--RNPFIV 64
Query: 129 TYNHVWLER-CPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNR 187
Y W+E+ C Y+ I+ +C+GG++ + I+
Sbjct: 65 EYKDSWVEKGC------------------------YVCIVIGYCKGGDMAEAIK------ 94
Query: 188 ISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLL 247
K + + + ++ + L+ LH+ I+HRD+K SN L
Sbjct: 95 -----------------KANGVEFSEEKLCKWLVQLLMALEYLHASHILHRDVKCSNIFL 137
Query: 248 LEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYA 307
++ D +GDFG +++ A+ GT ++ PEL + KSDI++
Sbjct: 138 TKDQDIR---------LGDFGLAKILTSDDLASSVVGTPSYMCPELLADIPYGSKSDIWS 188
Query: 308 FGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEM 367
G +Y + + F + DM + + IN +P A + +LV M
Sbjct: 189 LGCCMYEMTALKPAFKAFDMQGLINRINRSIVAPLP----------AQYSTAFRSLVKSM 238
Query: 368 LNHTPSLRPDSSQI 381
L P LRP +S +
Sbjct: 239 LRKNPELRPSASDL 252
>Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1036
Score = 66.6 bits (161), Expect = 8e-11
Identities = 44/161 (27%), Positives = 75/161 (46%), Gaps = 25/161 (15%)
Query: 164 MFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
+F++ ++C GG+L D +Q K L+ R+ L + I
Sbjct: 81 VFLVMEYCNGGDLADYLQ----------------AKGTLSEDTIRVFL---------HQI 115
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGST 283
A ++ LHS IIHRDLKP N LL R + + I DFG ++ A
Sbjct: 116 AAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLC 175
Query: 284 GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNS 324
G+ ++APE+ + K+D+++ G ++Y ++G+ PF +
Sbjct: 176 GSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQA 216
>Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1050
Score = 66.6 bits (161), Expect = 8e-11
Identities = 63/262 (24%), Positives = 107/262 (40%), Gaps = 55/262 (20%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLEN-ELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTE 122
F + ++G+G+ AVV+K +H + E+ + K + L KE+K+L L
Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLG---KEIKILKELKH 72
Query: 123 ESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQY 182
E+ + +L Q +SV +++ ++C GG+L D +
Sbjct: 73 EN---------------IVALYDFQEMANSV-----------YLVMEYCNGGDLADYL-- 104
Query: 183 QVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKP 242
+S + RL IA ++ LHS IIHRDLKP
Sbjct: 105 HAMRTLSEDTIRL-----------------------FLQQIAGAMRLLHSKGIIHRDLKP 141
Query: 243 SNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFK 302
N LL R + I DFG ++ A G+ ++APE+ + K
Sbjct: 142 QNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGK 201
Query: 303 SDIYAFGMILYFVIMGQLPFNS 324
+D+++ G I+Y + G+ PF +
Sbjct: 202 ADLWSIGTIVYQCLTGKAPFQA 223
>At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 310
Score = 66.6 bits (161), Expect = 8e-11
Identities = 61/263 (23%), Positives = 116/263 (43%), Gaps = 70/263 (26%)
Query: 65 KQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEES 124
+++ VLG G+ +VYKV+H +ALK + D + + ++E+++L R +S
Sbjct: 48 EKLNVLGCGNGGIVYKVRHKTTSE---IYALKTVNGDMDPIFTRQLMREMEILRRT--DS 102
Query: 125 SHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQV 184
+++ + ++ + E + IL ++ GG LE
Sbjct: 103 PYVVKCHGIFEKPVVGE----------------------VSILMEYMDGGTLESL----- 135
Query: 185 FNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSN 244
R G+T +++ A I GL LH+L+I+HRD+KP+N
Sbjct: 136 -----------------------RGGVTEQKLAGFAKQILKGLSYLHALKIVHRDIKPAN 172
Query: 245 CLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS-TGTVEFVAP-----ELTKGAQ 298
LL + + I DFG S++ + D+ S GT +++P E + G+
Sbjct: 173 LLL---------NSKNEVKIADFGVSKILVRSLDSCNSYVGTCAYMSPERFDSESSGGSS 223
Query: 299 FSFKSDIYAFGMILYFVIMGQLP 321
+ DI++FG+++ +++G P
Sbjct: 224 DIYAGDIWSFGLMMLELLVGHFP 246
>At1g08720 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 1015
Score = 66.6 bits (161), Expect = 8e-11
Identities = 52/189 (27%), Positives = 91/189 (47%), Gaps = 31/189 (16%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLR--IIHRDLKPSNCLLLEEFDRSDTD 257
++L+ KS I R+ + +A D+A G+ LH+ I+HRDLK N L+ D
Sbjct: 835 RILHRPKSHID--ERRRIKMALDVAMGMNCLHTSTPTIVHRDLKTPNLLV---------D 883
Query: 258 KFPKCVIGDFGESQL-YGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI 316
+GDFG S+L + + + GT E++APE+ + + K D+Y+FG+IL+ +
Sbjct: 884 NNWNVKVGDFGLSRLKHNTFLSSKSTAGTPEWMAPEVLRNEPSNEKCDVYSFGVILWELA 943
Query: 317 MGQLPFNSKD----MSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTP 372
+LP+ + + A+ + L E +DP + ++ E P
Sbjct: 944 TLRLPWRGMNPMQVVGAVGFQNRRLEIPKE-------------LDPVVGRIILECWQTDP 990
Query: 373 SLRPDSSQI 381
+LRP +Q+
Sbjct: 991 NLRPSFAQL 999
>YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 821
Score = 66.2 bits (160), Expect = 1e-10
Identities = 49/173 (28%), Positives = 83/173 (47%), Gaps = 29/173 (16%)
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCV-IGDFGESQLYGQLR 277
I+ I T +K +HS+ I HRDLKP N +L+E+ D P V I DFG +++ G
Sbjct: 299 ISRQILTAIKYIHSMGISHRDLKPDN-ILIEQDD-------PVLVKITDFGLAKVQGNGS 350
Query: 278 DATGSTGTVEFVAPELTKGA-------------QFSFKSDIYAFGMILYFVIMGQLPFNS 324
GT+ +VAPE+ +G ++S D+++ G ++Y ++ G LPF+
Sbjct: 351 FMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG 410
Query: 325 KDMSAIKHEINELSFSPEAM------SKLHDSLD-LAPIDPSLYNLVCEMLNH 370
+ +I S+ + + D +D L +DP+ + + LNH
Sbjct: 411 STQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNH 463
>Hs14150045 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 505
Score = 66.2 bits (160), Expect = 1e-10
Identities = 53/159 (33%), Positives = 76/159 (47%), Gaps = 24/159 (15%)
Query: 222 DIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQLRDAT 280
D+ GL+ LH +I+HRD+KPSN LL ++ I DFG S Q G +
Sbjct: 258 DVILGLEYLHCQKIVHRDIKPSNLLLGDD---------GHVKIADFGVSNQFEGNDAQLS 308
Query: 281 GSTGTVEFVAPEL--TKGAQFSFKS-DIYAFGMILYFVIMGQLPFNSKDMSAIKHEI-NE 336
+ GT F+APE G FS K+ D++A G+ LY + G+ PF + A+ +I NE
Sbjct: 309 STAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNE 368
Query: 337 LSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLR 375
PE I L +L+ +ML+ P R
Sbjct: 369 PVVFPEE----------PEISEELKDLILKMLDKNPETR 397
>At5g11015 [T] KOG1187 Serine/threonine protein kinase
Length = 402
Score = 66.2 bits (160), Expect = 1e-10
Identities = 42/108 (38%), Positives = 58/108 (52%), Gaps = 12/108 (11%)
Query: 217 VSIANDIATGLKQLHSL---RIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY 273
+ IA D+ GL+ LH IIHRDLK SN LL F+ I DFG + +
Sbjct: 210 MKIALDVTRGLEYLHEHCHPAIIHRDLKSSNILLDSNFNAK---------ISDFGLAVVD 260
Query: 274 GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLP 321
G +GTV +VAPE Q + KSD+YAFG++L +++G+ P
Sbjct: 261 GPKNKNHKLSGTVGYVAPEYLLNGQLTEKSDVYAFGVVLLELLLGKKP 308
>7299793 [T] KOG0583 Serine/threonine protein kinase
Length = 540
Score = 66.2 bits (160), Expect = 1e-10
Identities = 61/225 (27%), Positives = 94/225 (41%), Gaps = 46/225 (20%)
Query: 164 MFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
M+++ ++C GG L++ I YQ ++R L Q +
Sbjct: 221 MYLVMEYCVGG-LQEMIDYQP-----------DKRMPLF------------QAHGYFKQL 256
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQ---LYGQLRDAT 280
GL+ LHS R+IH+D+KP N LL D+ K I DFG ++ L+ T
Sbjct: 257 VDGLEYLHSCRVIHKDIKPGNLLL-------SLDQTLK--ISDFGVAEQLDLFAPDDTCT 307
Query: 281 GSTGTVEFVAPELTKGAQ--FSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELS 338
G+ F PE+ G + FK DI++ G+ LY + GQ PF ++ + I
Sbjct: 308 TGQGSPAFQPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQ 367
Query: 339 FSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQIEY 383
+ A L +D NL+ ML PS R +I +
Sbjct: 368 WEAPAW--------LYEMDADFANLILGMLQADPSKRLSLQEIRH 404
>At3g46920_2 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 505
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/170 (31%), Positives = 84/170 (48%), Gaps = 18/170 (10%)
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLL-LEEFDRSDTDKFPKCVIGDFGESQLYGQLR 277
IA DIA G++ LH +I+H DLK N L+ L + R P C +GD G S++ Q
Sbjct: 331 IAMDIAFGMEYLHGKKIVHFDLKSDNLLVNLRDPHR------PICKVGDLGLSKVKCQTL 384
Query: 278 DATGSTGTVEFVAPELTKGAQ--FSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEIN 335
+ G GT+ ++APEL G S K D+++FG++L+ + G+ P+ AI I
Sbjct: 385 ISGGVRGTLPWMAPELLNGTSSLVSEKVDVFSFGIVLWELFTGEEPYADLHYGAIIGGIV 444
Query: 336 ELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQIEYQL 385
+ P+ D +D L L+ + PS RP ++I +L
Sbjct: 445 SNTLRPQIP-------DFCDMDWKL--LMERCWSAEPSERPSFTEIVNEL 485
>YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 506
Score = 65.9 bits (159), Expect = 1e-10
Identities = 74/299 (24%), Positives = 128/299 (42%), Gaps = 63/299 (21%)
Query: 49 RIPEDIFVQGYYQRFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKI-CIGDDMHWL 107
++ E+ + G+ + +G+LG G+ V K + L+N FALK I + D +
Sbjct: 199 QLEEEAWRFGHLKDEITTLGILGEGAGGSVAKCR---LKNGKKVFALKTINTMNTDPEYQ 255
Query: 108 YRCLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFIL 167
+ +E++ +S +++ Y ++ T SS+ +I
Sbjct: 256 KQIFRELQFNKSF--KSDYIVQYYGMF-----------TDEQSSSI-----------YIA 291
Query: 168 QQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGL 227
++ G +LE T + N K ++ R I IA + GL
Sbjct: 292 MEYMGGKSLEATYK---------------------NLLKRGGRISERVIGKIAESVLRGL 330
Query: 228 KQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVE 287
LH ++IHRD+KP N LL E+ + C G GE+ L A TGT
Sbjct: 331 SYLHERKVIHRDIKPQNILLNEK------GEIKLCDFGVSGEA--VNSL--AMTFTGTSF 380
Query: 288 FVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNS----KDMSAIKHEINELSFSPE 342
++APE +G +S D+++ G+ L V G+ PF S ++++ I+ L+FSP+
Sbjct: 381 YMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQ 439
>YLR096w [T] KOG0583 Serine/threonine protein kinase
Length = 1147
Score = 65.9 bits (159), Expect = 1e-10
Identities = 43/156 (27%), Positives = 76/156 (48%), Gaps = 18/156 (11%)
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
Y +F +SG + LL++ L A IA+ L+ LH+ I+HRDLK
Sbjct: 199 YMLFEYVSGGQ--------LLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLK 250
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSF 301
N ++ + I DFG S ++ + G++ F APEL K ++
Sbjct: 251 IENIMISSSGEIK---------IIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTG 301
Query: 302 KS-DIYAFGMILYFVIMGQLPFNSKDMSAIKHEINE 336
DI++FG++LY ++ G++PF+ ++ S + +I +
Sbjct: 302 PEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKK 337
>CE12518 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 391
Score = 65.9 bits (159), Expect = 1e-10
Identities = 49/161 (30%), Positives = 74/161 (45%), Gaps = 32/161 (19%)
Query: 164 MFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
+FI+ Q GG + D + + G S E R L +
Sbjct: 137 LFIVMQMASGGEMYDRVVAK------GRYSEEEARNAL-------------------KML 171
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQLRDATGS 282
TGL LHS+R+ HRDLKP N L +D+ + +I DFG + Q T +
Sbjct: 172 LTGLTYLHSIRVTHRDLKPENLLY------ADSRPEARLLITDFGLAYQATKPNETMTET 225
Query: 283 TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFN 323
GT E++APEL ++ K D++A G+I Y ++ G +PF+
Sbjct: 226 CGTPEYIAPELLLRVPYTQKVDMWAVGVIAYILMSGIMPFD 266
>7292679 [G] KOG0599 Phosphorylase kinase gamma subunit
Length = 560
Score = 65.9 bits (159), Expect = 1e-10
Identities = 88/338 (26%), Positives = 136/338 (40%), Gaps = 76/338 (22%)
Query: 50 IPEDIFVQGYYQRFFKQVGVLGNGSRAVVYKVKHMLLENELGT-FALKKICIGDDMHWLY 108
+P+ +G+Y ++ + +LG G + V + +E E G FA K I +G
Sbjct: 10 LPDKDAAKGFYAKY-EPKEILGRGISSTVRRC----IEKETGKEFAAKIIDLG------- 57
Query: 109 RCLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMP---YMF 165
T ES Y+ LE E IL Q G +D+ ++F
Sbjct: 58 -----------ATTESGETNPYH--MLEATRQEISILRQVMGHPYIIDLQDVFESDAFVF 104
Query: 166 ILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIAT 225
++ + C G L D + V L+ KK+R +I I
Sbjct: 105 LVFELCPKGELFDYLTSVV----------------TLSEKKTR---------TIMRQIFE 139
Query: 226 GLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGT 285
G++ +H+ I+HRDLKP N LL D+ I DFG ++ + T GT
Sbjct: 140 GVEYIHAKSIVHRDLKPENILL---------DENHNVKITDFGFAKQLQEGEKLTNLCGT 190
Query: 286 VEFVAPELTKGAQF------SFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSF 339
++APE K F S + DI+A G+I++ +++G PF + + I E +
Sbjct: 191 PGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKY 250
Query: 340 ---SPEAMSKLHDSLDL----APIDPSLYNLVCEMLNH 370
SPE D DL +DPS V E+L H
Sbjct: 251 SFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRH 288
>At5g57610_2 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 282
Score = 65.9 bits (159), Expect = 1e-10
Identities = 53/183 (28%), Positives = 88/183 (47%), Gaps = 17/183 (9%)
Query: 205 KKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVI 264
KK R + R+ + IA D A G++ LH I+H DLK N L+ + D + P C I
Sbjct: 105 KKDRT-IDRRKRLIIAMDTAFGMEYLHGKNIVHFDLKCENLLV----NMRDPQR-PICKI 158
Query: 265 GDFGESQLYGQLRDATGSTGTVEFVAPELTKGA--QFSFKSDIYAFGMILYFVIMGQLPF 322
GD G S++ + + G GT+ ++APEL G S K D+Y+FG++++ ++ G+ P+
Sbjct: 159 GDLGLSKVKQKTLVSGGVRGTLPWMAPELLSGKSNMVSEKIDVYSFGIVMWELLTGEEPY 218
Query: 323 NSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQIE 382
++I I + P+ DP L+ P+ RP ++I
Sbjct: 219 ADMHCASIIGGIVNNALRPKIPQW---------CDPEWKGLMESCWTSEPTERPSFTEIS 269
Query: 383 YQL 385
+L
Sbjct: 270 QKL 272
>YDR466w [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 898
Score = 65.5 bits (158), Expect = 2e-10
Identities = 52/160 (32%), Positives = 80/160 (49%), Gaps = 29/160 (18%)
Query: 227 LKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG-----ESQLYGQLR---- 277
L+ +HS IIHRDLKP N LL D+ + +I DFG + L G
Sbjct: 126 LEFIHSHGIIHRDLKPENVLL---------DRDGRLMITDFGAAATIDPSLSGDSAKFNS 176
Query: 278 DATGS---------TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMS 328
D+ GS GT E+V+PEL Q + SDI+A G ++Y + GQ PF ++
Sbjct: 177 DSNGSKDNQNCASFVGTAEYVSPELLLYNQCGYGSDIWALGCMIYQFVQGQPPFRGENEL 236
Query: 329 AIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEML 368
+I L + +++++S +PI+P + NLV ++L
Sbjct: 237 KTFEKIVALDYPWGPNNRINNS--TSPINPLVINLVQKIL 274
>Hs7661974 [T] KOG0583 Serine/threonine protein kinase
Length = 651
Score = 65.5 bits (158), Expect = 2e-10
Identities = 79/332 (23%), Positives = 140/332 (41%), Gaps = 75/332 (22%)
Query: 62 RFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLT 121
++++ +G G A V H+L + + K +G D L R E++ L L
Sbjct: 9 KYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD---LPRIKTEIEALKNLR 65
Query: 122 EESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQ 181
+ H+ C + ++ T N +F++ ++C GG L D I
Sbjct: 66 HQ--------HI----CQLYHVLETANK--------------IFMVLEYCPGGELFDYII 99
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
Q +R+S E+R+ RQIVS + +HS HRDLK
Sbjct: 100 SQ--DRLSEEETRV----------------VFRQIVS-------AVAYVHSQGYAHRDLK 134
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGST--GTVEFVAPELTKGAQF 299
P N L D++ K + DFG +D T G++ + APEL +G +
Sbjct: 135 PENLLF---------DEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSY 185
Query: 300 -SFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSF------SPEAMSKLHDSLD 352
++D+++ G++LY ++ G LPF+ ++ A+ +I + SP ++ L L
Sbjct: 186 LGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQ 245
Query: 353 LAPIDPSLYNLVCEMLNHTPSLRPDSSQIEYQ 384
+DP + +LNH ++ + +E+Q
Sbjct: 246 ---VDPKKRISMKNLLNHPWIMQDYNYPVEWQ 274
>Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase
Length = 745
Score = 65.5 bits (158), Expect = 2e-10
Identities = 68/264 (25%), Positives = 113/264 (42%), Gaps = 60/264 (22%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEE 123
F+ + VLG GS V+ V+ + +A+K L + +V+ R E
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKV---------LKKASLKVRDRVRTKME 123
Query: 124 SSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQ 183
L+ NH ++ V+ Q +G ++++ F RGG+
Sbjct: 124 RDILVEVNHPFI----VKLHYAFQTEGK------------LYLILDFLRGGD-------- 159
Query: 184 VFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPS 243
VF R+S K++L T + ++A L LH L I++RDLKP
Sbjct: 160 VFTRLS---------KEVL--------FTEEDVKFYLAELALALDHLHQLGIVYRDLKPE 202
Query: 244 NCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQLRDATGSTGTVEFVAPELTKGAQFSFK 302
N LL D+ + DFG S + Q + A GTVE++APE+ S
Sbjct: 203 NILL---------DEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQS 253
Query: 303 SDIYAFGMILYFVIMGQLPFNSKD 326
+D +++G++++ ++ G LPF KD
Sbjct: 254 ADWWSYGVLMFEMLTGTLPFQGKD 277
Score = 55.1 bits (131), Expect = 2e-07
Identities = 36/110 (32%), Positives = 55/110 (49%), Gaps = 6/110 (5%)
Query: 214 RQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG-ESQL 272
R+ I I+ + LH ++HRDLKPSN L ++E +D+ + I DFG QL
Sbjct: 518 REASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIR-----ICDFGFAKQL 572
Query: 273 YGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
G+ T FVAPE+ + DI++ G++ Y ++ G PF
Sbjct: 573 RGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPF 622
>Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 685
Score = 65.5 bits (158), Expect = 2e-10
Identities = 50/186 (26%), Positives = 85/186 (44%), Gaps = 23/186 (12%)
Query: 198 RKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTD 257
R+ + + K+R LT ++ I +GLK LH I+HRDLK N + E +
Sbjct: 164 RRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELK--- 220
Query: 258 KFPKCVIGDFGESQLYGQLRDATGS-TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI 316
+GDFG + L + GT +++PE+ +SDI+A G ++Y ++
Sbjct: 221 ------VGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTML 274
Query: 317 MGQLPFNSKDMSAIKHEINELSFS-PEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLR 375
+G+ PF + ++ I E ++ P ++ LAP +L+ ML+ P R
Sbjct: 275 LGRPPFETTNLKETYRCIREARYTMPSSL--------LAPAK----HLIASMLSKNPEDR 322
Query: 376 PDSSQI 381
P I
Sbjct: 323 PSLDDI 328
>Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 454
Score = 65.1 bits (157), Expect = 2e-10
Identities = 47/179 (26%), Positives = 80/179 (44%), Gaps = 12/179 (6%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
+L + + LT + I G+ LHS RI H DLKP N +LL++ +
Sbjct: 100 ELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPN----- 154
Query: 260 PKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQ 319
P+ + DFG + + GT EFVAPE+ ++D+++ G+I Y ++ G
Sbjct: 155 PRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGA 214
Query: 320 LPFNSK-------DMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHT 371
PF + ++SA+ ++ +E FS + L DP + + L H+
Sbjct: 215 SPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHS 273
>Hs20545357 [T] KOG0583 Serine/threonine protein kinase
Length = 436
Score = 65.1 bits (157), Expect = 2e-10
Identities = 72/303 (23%), Positives = 132/303 (42%), Gaps = 58/303 (19%)
Query: 73 GSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNR--LTEESSHLITY 130
G R Y+++ E+G+ ++ +G +H L + +K+L++ L +++ L++
Sbjct: 68 GKRIGFYRIR-----GEIGSGNFSQVKLG--IHSLTKEKVAIKILDKTKLDQKTQRLLSR 120
Query: 131 NHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISG 190
+E+ ++I ++ T+ + ++ ++ GG L F +IS
Sbjct: 121 EISSMEKLHHPNIIRLY--------EVVETLSKLHLVMEYAGGGEL--------FGKIST 164
Query: 191 NESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEE 250
E KL I + I + +K +H +IIHRDLK N
Sbjct: 165 EGKLSEPESKL-----------------IFSQIVSAVKHMHENQIIHRDLKAENV----- 202
Query: 251 FDRSDTDKFPKCV-IGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQF-SFKSDIYAF 308
F S+T CV +GDFG S + + G+ + APEL + + DI+A
Sbjct: 203 FYTSNT-----CVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGIYVDIWAL 257
Query: 309 GMILYFVIMGQLPFNSKDMSAIKHEINELSFS--PEAMSKLHDSLD--LAPIDPSLYNLV 364
G++LYF++ G +PF ++ ++ +K I E ++S P H + L I Y +
Sbjct: 258 GVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIPTERYGID 317
Query: 365 CEM 367
C M
Sbjct: 318 CIM 320
>Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase
Length = 733
Score = 65.1 bits (157), Expect = 2e-10
Identities = 68/264 (25%), Positives = 110/264 (40%), Gaps = 60/264 (22%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEE 123
F+ + VLG GS V+ V+ + + +A+K L + +V+ R E
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKV---------LKKATLKVRDRVRSKME 109
Query: 124 SSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQ 183
L NH ++ V+ Q +G ++++ F RGG+L
Sbjct: 110 RDILAEVNHPFI----VKLHYAFQTEGK------------LYLILDFLRGGDL------- 146
Query: 184 VFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPS 243
F R+S + T + ++A L LHSL II+RDLKP
Sbjct: 147 -FTRLS-----------------KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPE 188
Query: 244 NCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQLRDATGSTGTVEFVAPELTKGAQFSFK 302
N LL EE I DFG S + + A GT+E++APE+ +
Sbjct: 189 NILLDEE---------GHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQS 239
Query: 303 SDIYAFGMILYFVIMGQLPFNSKD 326
+D ++FG++++ ++ G LPF KD
Sbjct: 240 ADWWSFGVLMFEMLTGSLPFQGKD 263
Score = 58.2 bits (139), Expect = 3e-08
Identities = 50/195 (25%), Positives = 83/195 (41%), Gaps = 41/195 (21%)
Query: 136 ERCPVESLILTQNDGSSVNM----DIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGN 191
+R P E + + G N+ D+ +++++ + RGG L D I Q +
Sbjct: 450 KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRY------ 503
Query: 192 ESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEF 251
+ R+ + I + LHS ++HRDLKPSN L +E
Sbjct: 504 -------------------FSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDES 544
Query: 252 DRSDTDKFPKCVIGDFGESQLYGQLRDATG----STGTVEFVAPELTKGAQFSFKSDIYA 307
++ + + DFG ++ QLR G T FVAPE+ K + DI++
Sbjct: 545 GSPESIR-----VCDFGFAK---QLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWS 596
Query: 308 FGMILYFVIMGQLPF 322
G++LY ++ G PF
Sbjct: 597 LGILLYTMLAGFTPF 611
>CE27768 [R] KOG0586 Serine/threonine protein kinase
Length = 1096
Score = 65.1 bits (157), Expect = 2e-10
Identities = 73/293 (24%), Positives = 121/293 (40%), Gaps = 71/293 (24%)
Query: 43 ARRRNSRIPEDIFVQGYYQRFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGD 102
A RRN +D+ V Y K + +G G+ A V KH++ +E+ + K +
Sbjct: 109 AARRND---QDVHVGKY-----KLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNP 160
Query: 103 DMHWLYRCLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMP 162
L + +EVK++ +L N V L + + T
Sbjct: 161 SS--LQKLFREVKIMKQLDHP-------NIVKLYQ-------------------VMETEQ 192
Query: 163 YMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIAND 222
++++ ++ GG + D Y V + G E R K RQIVS
Sbjct: 193 TLYLVLEYASGGEVFD---YLVAH---GRMKEKEARAKF------------RQIVS---- 230
Query: 223 IATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS 282
++ LHS IIHRDLK N LL D+ I DFG S +
Sbjct: 231 ---AVQYLHSKNIIHRDLKAENLLL---------DQDMNIKIADFGFSNTFSLGNKLDTF 278
Query: 283 TGTVEFVAPELTKGAQFSF-KSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
G+ + APEL G ++ + D+++ G+ILY ++ G LPF+ +++ ++ +
Sbjct: 279 CGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 331
>CE23838 [R] KOG0586 Serine/threonine protein kinase
Length = 1192
Score = 65.1 bits (157), Expect = 2e-10
Identities = 73/293 (24%), Positives = 121/293 (40%), Gaps = 71/293 (24%)
Query: 43 ARRRNSRIPEDIFVQGYYQRFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGD 102
A RRN +D+ V Y K + +G G+ A V KH++ +E+ + K +
Sbjct: 157 AARRND---QDVHVGKY-----KLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNP 208
Query: 103 DMHWLYRCLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMP 162
L + +EVK++ +L N V L + + T
Sbjct: 209 SS--LQKLFREVKIMKQLDHP-------NIVKLYQ-------------------VMETEQ 240
Query: 163 YMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIAND 222
++++ ++ GG + D Y V + G E R K RQIVS
Sbjct: 241 TLYLVLEYASGGEVFD---YLVAH---GRMKEKEARAKF------------RQIVS---- 278
Query: 223 IATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS 282
++ LHS IIHRDLK N LL D+ I DFG S +
Sbjct: 279 ---AVQYLHSKNIIHRDLKAENLLL---------DQDMNIKIADFGFSNTFSLGNKLDTF 326
Query: 283 TGTVEFVAPELTKGAQFSF-KSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
G+ + APEL G ++ + D+++ G+ILY ++ G LPF+ +++ ++ +
Sbjct: 327 CGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 379
>7302048 [J] KOG1035 eIF-2alpha kinase GCN2
Length = 1589
Score = 65.1 bits (157), Expect = 2e-10
Identities = 70/245 (28%), Positives = 99/245 (39%), Gaps = 67/245 (27%)
Query: 161 MPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIA 220
M M+I +FC L I +FN T ++ +
Sbjct: 691 MQVMYIQMEFCEKCTLRTAIDDNLFN-------------------------DTDRLWRLF 725
Query: 221 NDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG---ESQLYGQLR 277
+IA GL +H IIHRDLKP N L D + IGDFG S L Q
Sbjct: 726 REIAEGLAHIHQQGIIHRDLKPVNIFL---------DSHDQIKIGDFGLATTSFLALQAH 776
Query: 278 DA----------------TGSTGTVEFVAPELTKGAQ---FSFKSDIYAFGMILYFVIMG 318
DA TG GT +VAPELT A ++ K D+Y G+IL+ M
Sbjct: 777 DAAPAPVNQITSAEDGTGTGKVGTTLYVAPELTGNASKSVYNQKVDMYTLGIILF--EMC 834
Query: 319 QLPFN-SKDMSAIKHEINELSFS-PEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRP 376
Q PF+ S + + + +S + P+AM K P ++ +LNH P+ RP
Sbjct: 835 QPPFDTSMERAQTIMALRNVSINIPDAMLK-------DPKYEKTVKMLQWLLNHDPAQRP 887
Query: 377 DSSQI 381
+ ++
Sbjct: 888 TAEEL 892
>YKL048c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 640
Score = 64.7 bits (156), Expect = 3e-10
Identities = 45/134 (33%), Positives = 64/134 (47%), Gaps = 12/134 (8%)
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIG----DFGESQLYG 274
I D+ GL+ LHS IHRD+KPSN LL EE + F C+ F ++
Sbjct: 239 ILEDMTKGLEYLHSQGCIHRDIKPSNILLDEEEKVAKLSDFGSCIFTPQSLPFSDANFED 298
Query: 275 QL-RDATGSTGTVEFVAPELTKGAQF-------SFKSDIYAFGMILYFVIMGQLPFNSKD 326
R+ GT F+APEL FK DI++ G+ LY ++ +LPF ++
Sbjct: 299 CFQRELNKIVGTPAFIAPELCHLGNSKRDFVTDGFKLDIWSLGVTLYCLLYNELPFFGEN 358
Query: 327 MSAIKHEINELSFS 340
H+I E+S S
Sbjct: 359 EFETYHKIIEVSLS 372
>Hs4507275 [D] KOG0580 Serine/threonine protein kinase
Length = 403
Score = 64.7 bits (156), Expect = 3e-10
Identities = 42/156 (26%), Positives = 74/156 (46%), Gaps = 23/156 (14%)
Query: 222 DIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATG 281
++A L HS R+IHRD+KP N LL + I DFG S ++ T
Sbjct: 239 ELANALSYCHSKRVIHRDIKPENLLL---------GSAGELKIADFGWS-VHAPSSRRTT 288
Query: 282 STGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFS- 340
GT++++ PE+ +G K D+++ G++ Y ++G+ PF + I+ + F+
Sbjct: 289 LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF 348
Query: 341 PEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRP 376
P+ +++ +L+ +L H PS RP
Sbjct: 349 PDFVTE------------GARDLISRLLKHNPSQRP 372
>Hs22043888 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 765
Score = 64.7 bits (156), Expect = 3e-10
Identities = 50/172 (29%), Positives = 76/172 (44%), Gaps = 42/172 (24%)
Query: 160 TMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSI 219
T +F++ + +GG+L D I S T R ++
Sbjct: 283 TATELFLVMELVKGGDLFDAIT-------------------------SSTKYTERDGSAM 317
Query: 220 ANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG-----ESQLYG 274
++A L+ LH L I+HRD+KP N L+ E D + + K +GDFG E LY
Sbjct: 318 VYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLK-----LGDFGLATVVEGPLY- 371
Query: 275 QLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKD 326
GT +VAPE+ + K DI+A G+I Y ++ G PF S++
Sbjct: 372 ------TVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSEN 417
>CE17343 [T] KOG0583 Serine/threonine protein kinase
Length = 367
Score = 64.7 bits (156), Expect = 3e-10
Identities = 43/165 (26%), Positives = 78/165 (47%), Gaps = 35/165 (21%)
Query: 163 YMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIAND 222
++ + ++C GG+L L + K ++ K+ T RQ+++
Sbjct: 143 HIIFVNEYCAGGDL------------------LRKMKDIVAMKEEDAKFTFRQLIA---- 180
Query: 223 IATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS 282
L L S I+HRDLK N + DK +GDFG S++ +
Sbjct: 181 ---ALTHLQSYNIVHRDLKCENIFM---------DKHGNVKLGDFGFSRILKPGEKSGTF 228
Query: 283 TGTVEFVAPELTKGAQFSFKS-DIYAFGMILYFVIMGQLPFNSKD 326
G+ +VAPE+ +G ++S + D+++ G+ILY ++ G +PF+ +D
Sbjct: 229 CGSRAYVAPEIFRGREYSGNAVDVWSTGVILYIMLAGSMPFDDRD 273
>CE15235 [R] KOG0589 Serine/threonine protein kinase
Length = 357
Score = 64.7 bits (156), Expect = 3e-10
Identities = 54/216 (25%), Positives = 93/216 (43%), Gaps = 34/216 (15%)
Query: 166 ILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIAT 225
I+ Q+ GG LE RL ++ + R + ++ I
Sbjct: 80 IVMQYAEGGTLE----------------RLINDQRAIKDSNMREYFPEKTVLDYFTQILI 123
Query: 226 GLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGT 285
L +H I+HRDLKP N L+ +R T + DFG S+ G A+ GT
Sbjct: 124 ALNHMHQKNIVHRDLKPQNILM----NRRKT----VLKLSDFGISKELGTKSAASTVIGT 175
Query: 286 VEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMS 345
+++PE+ + ++ KSD+++ G +LY ++ + F+ +++ AI +I +P
Sbjct: 176 PNYLSPEICESRPYNQKSDMWSLGCVLYELLQLERAFDGENLPAIVMKITRSKQNP---- 231
Query: 346 KLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
L D + + LV +L RPD SQ+
Sbjct: 232 -LGDH-----VSNDVKMLVENLLKTHTDKRPDVSQL 261
>At5g56790 [T] KOG1187 Serine/threonine protein kinase
Length = 710
Score = 64.7 bits (156), Expect = 3e-10
Identities = 53/191 (27%), Positives = 86/191 (44%), Gaps = 35/191 (18%)
Query: 209 IGLTTRQIVSIANDIATGLKQLHSLR----IIHRDLKPSNCLLLEEFDRSDTDKFPKCVI 264
+G + RQ +++ A GL+ LH I+HRD++P+N LL +F+ ++
Sbjct: 472 LGWSARQKIAVG--AARGLRYLHEECRVGCIVHRDMRPNNILLTHDFEP---------LV 520
Query: 265 GDFGES--QLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
GDFG + Q G T GT ++APE + Q + K+D+Y+FG++L +I G+
Sbjct: 521 GDFGLARWQPEGDKGVETRVIGTFGYLAPEYAQSGQITEKADVYSFGVVLVELITGRKAM 580
Query: 323 NSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEM------------LNH 370
+ IK + + A L +DP L N CE +
Sbjct: 581 D------IKRPKGQQCLTEWARPLLQKQAINELLDPRLMNCYCEQEVYCMALCAYLCIRR 634
Query: 371 TPSLRPDSSQI 381
P+ RP SQ+
Sbjct: 635 DPNSRPRMSQV 645
>At5g39440 [T] KOG0583 Serine/threonine protein kinase
Length = 494
Score = 64.7 bits (156), Expect = 3e-10
Identities = 46/153 (30%), Positives = 75/153 (48%), Gaps = 16/153 (10%)
Query: 223 IATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS 282
I +G++ H I+HRDLKP N LL D I DFG S + S
Sbjct: 126 IISGVEYCHRNMIVHRDLKPENVLL---------DSQCNIKIVDFGLSNVMHDGHFLKTS 176
Query: 283 TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFS-P 341
G+ + APE+ G + DI++ G+ILY ++ G LPF+ +++ + +I ++ P
Sbjct: 177 CGSPNYAAPEVISGKPYGPDVDIWSCGVILYALLCGTLPFDDENIPNVFEKIKRGMYTLP 236
Query: 342 EAMSKLHDSLDLAP----IDPSLYNLVCEMLNH 370
+S H + DL P +DP++ + E+ H
Sbjct: 237 NHLS--HFARDLIPRMLMVDPTMRISITEIRQH 267
>At3g58640 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 816
Score = 64.7 bits (156), Expect = 3e-10
Identities = 48/156 (30%), Positives = 77/156 (48%), Gaps = 32/156 (20%)
Query: 159 TTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVS 218
T P + ++ ++ G+L Y + + +SG + RL R+KL
Sbjct: 625 TKPPRLSLITEYMEMGSL-----YYLLH-LSGQKKRLSWRRKL----------------K 662
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY-GQLR 277
+ DI GL +H + I+HRD+K +NCLL ++ I DFG S++ G
Sbjct: 663 MLRDICRGLMCIHRMGIVHRDIKSANCLLSNKW---------TVKICDFGLSRIMTGTTM 713
Query: 278 DATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILY 313
T S GT E++APEL + FS K DI++ G+I++
Sbjct: 714 RDTVSAGTPEWMAPELIRNEPFSEKCDIFSLGVIMW 749
>7302050 [T] KOG0986 G protein-coupled receptor kinase
Length = 714
Score = 64.7 bits (156), Expect = 3e-10
Identities = 37/116 (31%), Positives = 58/116 (49%), Gaps = 9/116 (7%)
Query: 220 ANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDA 279
A ++A GL+ LH I++RD KP N LL D I D G + +
Sbjct: 416 AAEVACGLQHLHKQGIVYRDCKPENILL---------DDHGHVRISDLGLAVEIPEGEMV 466
Query: 280 TGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEIN 335
G GTV ++APE+ +++F D ++FG +LY +I GQ PF + + E++
Sbjct: 467 RGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVD 522
>YKL101w [D] KOG0588 Serine/threonine protein kinase
Length = 1518
Score = 64.3 bits (155), Expect = 4e-10
Identities = 52/193 (26%), Positives = 87/193 (44%), Gaps = 20/193 (10%)
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
Y V + G E L ++ S+ L R+ + I G+ HS I HRDLK
Sbjct: 190 YLVLEYVDGGE--------LFDYLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLK 241
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQF-S 300
P N LLL++ +R + I DFG + L + S G+ + +PE+ G +
Sbjct: 242 PEN-LLLDKKNR-------RIKIADFGMAALELPNKLLKTSCGSPHYASPEIVMGRPYHG 293
Query: 301 FKSDIYAFGMILYFVIMGQLPFNSKDMS--AIKHEINELSFSPEAMSKLHDSLD-LAPID 357
SD+++ G++L+ ++ G LPFN ++ +K + + S+ D + + ID
Sbjct: 294 GPSDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQMPSNLSSEARDLISKILVID 353
Query: 358 PSLYNLVCEMLNH 370
P E+L H
Sbjct: 354 PEKRITTQEILKH 366
>SPBC4C3.11 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 420
Score = 64.3 bits (155), Expect = 4e-10
Identities = 58/191 (30%), Positives = 88/191 (45%), Gaps = 28/191 (14%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
+LL + K L + A +I + ++ +HS IIHRDLKP N L FD + K
Sbjct: 139 ELLQYIKKYRFLDENCVRFYAAEILSSIEYMHSCGIIHRDLKPENIL----FDGNMHVK- 193
Query: 260 PKCVIGDFGESQL----YGQLRDAT----GSTGTVEFVAPELTKGAQFSFKSDIYAFGMI 311
I DFG +++ Y D T GT E+VAPEL S SD++AF +
Sbjct: 194 ----ITDFGTAKILPPKYVNSPDYTTFPSSFVGTAEYVAPELLSRQVVSKSSDLWAFACV 249
Query: 312 LYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHT 371
+Y +I+G PF+ + + I +I L + + KL + P + L +
Sbjct: 250 VYQMIVGSPPFHGSNPNNIFKKIMSLEYE---LPKL--------LPPDIVPLFSHLFRIQ 298
Query: 372 PSLRPDSSQIE 382
PS R + QI+
Sbjct: 299 PSDRSTTQQIK 309
>Hs20547878 [R] KOG0589 Serine/threonine protein kinase
Length = 758
Score = 64.3 bits (155), Expect = 4e-10
Identities = 53/220 (24%), Positives = 101/220 (45%), Gaps = 44/220 (20%)
Query: 164 MFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
+FI+ ++C GG+L R+ R++ +L + QI+ I
Sbjct: 52 LFIVMEYCDGGDLM---------------KRINRQRGVL--------FSEDQILGWFVQI 88
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQ-LYGQLRDATGS 282
+ GLK +H +I+HRD+K N L S K +GDFG ++ L + A
Sbjct: 89 SLGLKHIHDRKILHRDIKAQNIFL------SKNGMVAK--LGDFGIARVLNNSMELARTC 140
Query: 283 TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPE 342
GT +++PE+ + ++ K+DI++ G +LY + + PF ++ + +I + F+P
Sbjct: 141 IGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAP- 199
Query: 343 AMSKLHDSLDLAP-IDPSLYNLVCEMLNHTPSLRPDSSQI 381
++P L++L+ ++ +P RP + I
Sbjct: 200 ----------ISPGFSRELHSLISQLFQVSPRDRPSINSI 229
>ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 488
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/176 (28%), Positives = 81/176 (45%), Gaps = 25/176 (14%)
Query: 211 LTTRQIVSIANDIATGLKQLH-SLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGE 269
L R + GL LH S+ ++HRDLK N L +F+ IGDFG
Sbjct: 134 LKERHVARFVKQTVEGLIYLHNSVSVVHRDLKLGNLFLDSKFNVK---------IGDFGL 184
Query: 270 SQLYGQLRDATGSTGTVEFVAPELT--KGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDM 327
S + GT ++APE+ K + SF++DI++ G+I+Y +++G PF K++
Sbjct: 185 SAVIKDGEKKVTMCGTPNYIAPEVLFGKASGHSFEADIWSLGVIIYTLLVGVPPFQKKNV 244
Query: 328 SAIKH--EINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
I ++N F PE +++D L+ ++LN P RP I
Sbjct: 245 EDIYKMIKLNNYIF-PENCDLSSEAID----------LITQILNTNPLERPTLEHI 289
>At5g49470 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 730
Score = 64.3 bits (155), Expect = 4e-10
Identities = 47/129 (36%), Positives = 75/129 (57%), Gaps = 16/129 (12%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLR--IIHRDLKPSNCLLLEEFDRSDTD 257
+LL S+ L R+ + +A+DIA G+ LH IIHRDLK SN L+ D++ T
Sbjct: 575 RLLQRNTSK--LDWRRRIHMASDIARGMNYLHHCTPPIIHRDLKSSNLLV----DKNWTV 628
Query: 258 KFPKCVIGDFGESQLYGQ--LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFV 315
K + DFG S++ + L TG GT +++APE+ + KSD+Y+FG+IL+ +
Sbjct: 629 K-----VADFGLSRIKHETYLTTKTGR-GTPQWMAPEVLRNEAADEKSDVYSFGVILWEL 682
Query: 316 IMGQLPFNS 324
+ ++P+ S
Sbjct: 683 VTEKIPWES 691
>HsM4505263 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 953
Score = 63.9 bits (154), Expect = 5e-10
Identities = 52/171 (30%), Positives = 92/171 (53%), Gaps = 18/171 (10%)
Query: 216 IVSIANDIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSD-TDKFPKCVIGDFGESQ 271
+V+ A +A G+ LH+ + IIHRDLK N L+LE + + D K I DFG ++
Sbjct: 196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLK--ITDFGLAR 253
Query: 272 LYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIK 331
+ + + + GT ++APE+ + + FS SD+++FG++L+ ++ G++P+ D A+
Sbjct: 254 EWHKTTKMSAA-GTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVA 312
Query: 332 HEINELSFSPEAMSKLHDSLDLAPIDPSLY-NLVCEMLNHTPSLRPDSSQI 381
+ + AM+KL +L + P + L+ E + P RPD I
Sbjct: 313 YGV--------AMNKL--TLPIPSTCPEPFARLLEECWDPDPHGRPDFGSI 353
>Hs21735550 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 954
Score = 63.9 bits (154), Expect = 5e-10
Identities = 52/171 (30%), Positives = 92/171 (53%), Gaps = 18/171 (10%)
Query: 216 IVSIANDIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSD-TDKFPKCVIGDFGESQ 271
+V+ A +A G+ LH+ + IIHRDLK N L+LE + + D K I DFG ++
Sbjct: 196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLK--ITDFGLAR 253
Query: 272 LYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIK 331
+ + + + GT ++APE+ + + FS SD+++FG++L+ ++ G++P+ D A+
Sbjct: 254 EWHKTTKMSAA-GTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVA 312
Query: 332 HEINELSFSPEAMSKLHDSLDLAPIDPSLY-NLVCEMLNHTPSLRPDSSQI 381
+ + AM+KL +L + P + L+ E + P RPD I
Sbjct: 313 YGV--------AMNKL--TLPIPSTCPEPFARLLEECWDPDPHGRPDFGSI 353
>Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 476
Score = 63.9 bits (154), Expect = 5e-10
Identities = 57/199 (28%), Positives = 87/199 (43%), Gaps = 26/199 (13%)
Query: 179 TIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHR 238
T Y V +SG E L + R T + + + + +K LH I+HR
Sbjct: 91 THYYLVMQLVSGGE--------LFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 142
Query: 239 DLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY--GQLRDATGSTGTVEFVAPELTKG 296
DLKP N L L + S K +I DFG S++ G + A G+ G +VAPE+
Sbjct: 143 DLKPENLLYLTPEENS------KIMITDFGLSKMEQNGIMSTACGTPG---YVAPEVLAQ 193
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S D ++ G+I Y ++ G PF + S + +I E + E S D I
Sbjct: 194 KPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYY--EFESPFWDD-----I 246
Query: 357 DPSLYNLVCEMLNHTPSLR 375
S + +C +L P+ R
Sbjct: 247 SESAKDFICHLLEKDPNER 265
>CE28643 [T] KOG0583 Serine/threonine protein kinase
Length = 564
Score = 63.9 bits (154), Expect = 5e-10
Identities = 68/288 (23%), Positives = 124/288 (42%), Gaps = 51/288 (17%)
Query: 80 KVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHLITYNHVWLERCP 139
K+ H +L+ LG K+ +G +H + VK+LNR +S + V R
Sbjct: 21 KIGHYILKETLGVGTFGKVKVG--IHETTQYKVAVKILNRQKIKSLDV-----VGKIRRE 73
Query: 140 VESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRK 199
+++L L ++ + +T +F++ + GG L D I
Sbjct: 74 IQNLSLFRHPHIIRLYQVISTPSDIFMIMEHVSGGELFDYI------------------- 114
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
+ H + L T + I +G+ H ++HRDLKP N LL D+
Sbjct: 115 --VKHGR----LKTAEARRFFQQIISGVDYCHRHMVVHRDLKPENLLL---------DEQ 159
Query: 260 PKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSF-KSDIYAFGMILYFVIMG 318
I DFG S + S G+ + APE+ G ++ + D+++ G+ILY ++ G
Sbjct: 160 NNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCG 219
Query: 319 QLPFNSKDMSAIKHEINELSF-SPEAMSKLHDSLDLAPIDPSLYNLVC 365
LPF+ + + ++ +I F +P+ + + PI L++++C
Sbjct: 220 TLPFDDEHVPSLFRKIKSGVFPTPDFLER--------PIVNLLHHMLC 259
>CE17284 [T] KOG0583 Serine/threonine protein kinase
Length = 726
Score = 63.9 bits (154), Expect = 5e-10
Identities = 73/293 (24%), Positives = 119/293 (39%), Gaps = 61/293 (20%)
Query: 61 QRFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRL 120
Q F+ LG+G V H+L ++ + K +G D L R E+ L L
Sbjct: 8 QGFYAVHDELGSGGFGKVRLATHLLTNQKVAIKIIDKKQLGHD---LPRVQTEMDALRNL 64
Query: 121 TEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTI 180
+ ++ C + I T++ FI+ ++C GG + D I
Sbjct: 65 SHQNI------------CRLYHYIETEDK--------------FFIVMEYCSGGEMFDYI 98
Query: 181 QYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDL 240
RK+ L ++R RQ+VS + +HS HRDL
Sbjct: 99 V----------------RKERLEESEARHFF--RQLVS-------AIAFVHSQGYAHRDL 133
Query: 241 KPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFS 300
KP N LL E+ D F C + G + + G+ + APEL +G Q+
Sbjct: 134 KPENLLLTEDLHLKLID-FGLCAKTEKGRIDKH----NLDTCCGSPAYAAPELIQGLQYK 188
Query: 301 F-KSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSF-SPEAMSKLHDSL 351
++D+++ G++LY +++G LPF +M + +I F PE +S L L
Sbjct: 189 GNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQL 241
>CE07458 [T] KOG0583 Serine/threonine protein kinase
Length = 562
Score = 63.9 bits (154), Expect = 5e-10
Identities = 68/288 (23%), Positives = 124/288 (42%), Gaps = 51/288 (17%)
Query: 80 KVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHLITYNHVWLERCP 139
K+ H +L+ LG K+ +G +H + VK+LNR +S + V R
Sbjct: 21 KIGHYILKETLGVGTFGKVKVG--IHETTQYKVAVKILNRQKIKSLDV-----VGKIRRE 73
Query: 140 VESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRK 199
+++L L ++ + +T +F++ + GG L D I
Sbjct: 74 IQNLSLFRHPHIIRLYQVISTPSDIFMIMEHVSGGELFDYI------------------- 114
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
+ H + L T + I +G+ H ++HRDLKP N LL D+
Sbjct: 115 --VKHGR----LKTAEARRFFQQIISGVDYCHRHMVVHRDLKPENLLL---------DEQ 159
Query: 260 PKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSF-KSDIYAFGMILYFVIMG 318
I DFG S + S G+ + APE+ G ++ + D+++ G+ILY ++ G
Sbjct: 160 NNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCG 219
Query: 319 QLPFNSKDMSAIKHEINELSF-SPEAMSKLHDSLDLAPIDPSLYNLVC 365
LPF+ + + ++ +I F +P+ + + PI L++++C
Sbjct: 220 TLPFDDEHVPSLFRKIKSGVFPTPDFLER--------PIVNLLHHMLC 259
>At5g12180 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 528
Score = 63.9 bits (154), Expect = 5e-10
Identities = 49/170 (28%), Positives = 80/170 (46%), Gaps = 18/170 (10%)
Query: 214 RQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY 273
R S+ I + HS+ +IHRDLKP N LLL + + S DFG S Y
Sbjct: 172 RAAASLLRTIVQIVHTCHSMGVIHRDLKPENFLLLNKDENSPLK------ATDFGLSVFY 225
Query: 274 GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHE 333
G+ ++APE+ K ++ ++DI++ G++LY ++ G PF ++ + I +
Sbjct: 226 KPGEVFKDIVGSAYYIAPEVLK-RKYGPEADIWSIGVMLYILLCGVPPFWAESENGIFNA 284
Query: 334 I--NELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
I + FS + I P +LV +MLN P R ++Q+
Sbjct: 285 ILRGHVDFSSDPWPS---------ISPQAKDLVKKMLNSDPKQRLTAAQV 325
>At5g02070 [T] KOG1187 Serine/threonine protein kinase
Length = 657
Score = 63.9 bits (154), Expect = 5e-10
Identities = 69/273 (25%), Positives = 116/273 (42%), Gaps = 66/273 (24%)
Query: 138 CPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLER 197
C V L + G V++++P ++ +F G L F + G+ R +
Sbjct: 412 CQVNHRSLVRLLGCCVDLELP------LLIYEFIPNGTL--------FEHLHGSSDRTWK 457
Query: 198 RKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLR---IIHRDLKPSNCLLLEEFDRS 254
LT R+ + IA A GL LHS I HRD+K SN LL E+ +
Sbjct: 458 P------------LTWRRRLQIAYQTAEGLAYLHSAAQPPIYHRDVKSSNILLDEKLNAK 505
Query: 255 DTDKFPKCVIGDFGESQLYGQLRDA-------TGSTGTVEFVAPELTKGAQFSFKSDIYA 307
+ DFG S+L A TG+ GT+ ++ PE + Q + KSD+Y+
Sbjct: 506 ---------VSDFGLSRLVDLTETANNESHIFTGAQGTLGYLDPEYYRNFQLTDKSDVYS 556
Query: 308 FGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAM-------------SKLHDSLDLA 354
FG++L ++ + + D + + ++N + + + M K + +D+
Sbjct: 557 FGVVLLEMVTSK---KAIDFTREEEDVNLVMYINKMMDQERLTECIDPLLKKTANKIDMQ 613
Query: 355 PIDPSLYNLVCEMLN----HTPSLRPDSSQIEY 383
I L NL LN + PS++ + +IEY
Sbjct: 614 TIQ-QLGNLASACLNERRQNRPSMKEVADEIEY 645
>At3g27560 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 356
Score = 63.9 bits (154), Expect = 5e-10
Identities = 58/192 (30%), Positives = 88/192 (45%), Gaps = 28/192 (14%)
Query: 198 RKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTD 257
RK L++ + R+ + R V A DIA ++ LHS IIHRDLKP N +L S
Sbjct: 111 RKYLVSLRPKRLDI--RLAVGFALDIARAMECLHSHGIIHRDLKPENLIL------SADH 162
Query: 258 KFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPEL--------TKGAQFSFKSDIYAFG 309
K K + DFG ++ T TGT ++APEL + ++ K D Y+F
Sbjct: 163 KTVK--LADFGLAREESLTEMMTAETGTYRWMAPELYSTVTLRQGEKKHYNHKVDAYSFA 220
Query: 310 MILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLN 369
++L+ +I+ +LPF N + A L S + P D L +V
Sbjct: 221 IVLWELILNKLPFEGMS--------NLQAAYAAAFKNLRPSAEDLPGD--LEMIVTSCWK 270
Query: 370 HTPSLRPDSSQI 381
P+ RP+ ++I
Sbjct: 271 EDPNERPNFTEI 282
>YPL150w [T] KOG0583 Serine/threonine protein kinase
Length = 901
Score = 63.5 bits (153), Expect = 6e-10
Identities = 53/185 (28%), Positives = 81/185 (43%), Gaps = 22/185 (11%)
Query: 199 KKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDK 258
K+L +H S ++ + + I+ + HS+ +HRDLK N LL DK
Sbjct: 117 KELYDHLLSLRRISLLECGELFAQISGAVYYAHSMHCVHRDLKLENILL---------DK 167
Query: 259 FPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFS-FKSDIYAFGMILYFVIM 317
+ DFG ++ GT ++APEL + + FK DI++ G+ILY +I
Sbjct: 168 NGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPELIERRTYDGFKIDIWSLGVILYTLIT 227
Query: 318 GQLPFNSKDMSAIKHEI-NELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRP 376
G LPF+ D + K +I NE D I +L+ +L P RP
Sbjct: 228 GYLPFDDDDEAKTKWKIVNE-----------EPKYDAKVIPDDARDLISRLLAKNPGERP 276
Query: 377 DSSQI 381
SQ+
Sbjct: 277 SLSQV 281
>SPBC557.04 [T] KOG1989 ARK protein kinase family
Length = 872
Score = 63.5 bits (153), Expect = 6e-10
Identities = 62/230 (26%), Positives = 94/230 (39%), Gaps = 55/230 (23%)
Query: 164 MFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
+ +L ++C GG L D + ++ R+S +E ++ I +DI
Sbjct: 109 ILLLMEYCAGGGLIDFMNQRLQTRLSEHE-----------------------VLKIISDI 145
Query: 224 ATGLKQLHSLR--IIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGE-------SQLYG 274
G+ LH LR +IHRDLK N LL + F C G E S
Sbjct: 146 VQGVASLHYLRPPLIHRDLKVENVLL-------SFNTFKLCDFGSVTEPMHAAENSSEIQ 198
Query: 275 QLRDATGSTGTVEFVAPE---LTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIK 331
L + + T ++ APE L G KSD++A G++LY + PF ++ +AI
Sbjct: 199 ALEKSINTFTTYQYRAPEMINLYSGLGIDEKSDMWALGVLLYKLCYYTTPFETQGPNAIL 258
Query: 332 HEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
SF P P SL N++ +L P LRP+ Q+
Sbjct: 259 --TASYSFPP-----------FPPYSHSLKNVIIALLQPNPCLRPNIFQL 295
>Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 357
Score = 63.5 bits (153), Expect = 6e-10
Identities = 56/231 (24%), Positives = 96/231 (41%), Gaps = 39/231 (16%)
Query: 156 DIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQ 215
DI + +++++ Q GG L D I + F T +
Sbjct: 86 DIYESPNHLYLVMQLVSGGELFDRIVEKGF-------------------------YTEKD 120
Query: 216 IVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQ 275
++ + + LH + I+HRDLKP N L + + S K +I DFG S++ G+
Sbjct: 121 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEES------KIMISDFGLSKMEGK 174
Query: 276 LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI- 334
+ + GT +VAPE+ +S D ++ G+I Y ++ G PF ++ S + +I
Sbjct: 175 GDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQIL 234
Query: 335 -NELSFSPEAMSKLHDSL-----DLAPIDPSLYNLVCEMLNHTPSLRPDSS 379
E F + DS +L DP+ CE P + D++
Sbjct: 235 KAEYEFDSPYWDDISDSAKDFIRNLMEKDPN-KRYTCEQAARHPWIAGDTA 284
>Hs4758192 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 414
Score = 63.5 bits (153), Expect = 6e-10
Identities = 41/139 (29%), Positives = 65/139 (46%), Gaps = 8/139 (5%)
Query: 214 RQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY 273
+ + + I G+ LH+ ++H DLKP N LL E D I DFG S++
Sbjct: 161 KDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIK------IVDFGLSRIL 214
Query: 274 GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF--NSKDMSAIK 331
+ GT E+VAPE+ S +D+++ G++ Y ++ G PF N K + +
Sbjct: 215 KNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLN 274
Query: 332 HEINELSFSPEAMSKLHDS 350
LS+S E L +S
Sbjct: 275 ISQMNLSYSEEEFDVLSES 293
>Hs4506529 [T] KOG0986 G protein-coupled receptor kinase
Length = 563
Score = 63.5 bits (153), Expect = 6e-10
Identities = 44/142 (30%), Positives = 65/142 (44%), Gaps = 14/142 (9%)
Query: 198 RKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTD 257
R + N + G + + I GL+ LH RI++RDLKP N LL D
Sbjct: 276 RYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLL---------D 326
Query: 258 KFPKCVIGDFGES-QLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI 316
I D G + +L G GT F+APEL +G ++ F D +A G+ LY +I
Sbjct: 327 NDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMI 386
Query: 317 MGQLPFNSK----DMSAIKHEI 334
+ PF ++ + +KH I
Sbjct: 387 AARGPFRARGEKVENKELKHRI 408
>CE25585 [T] KOG0193 Serine/threonine protein kinase RAF
Length = 813
Score = 63.5 bits (153), Expect = 6e-10
Identities = 53/214 (24%), Positives = 93/214 (42%), Gaps = 61/214 (28%)
Query: 162 PYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIAN 221
P + I+ Q+C G +L I Q + R+ I+ I
Sbjct: 547 PEIAIITQWCEGSSLYRHIHVQ----------------------EPRVEFEMGAIIDILK 584
Query: 222 DIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATG 281
++ G+ LHS IIHRDLK +N L+ D IGDFG + + + G
Sbjct: 585 QVSLGMNYLHSKNIIHRDLKTNNIFLM--------DDMSTVKIGDFGLATVKTKWTVNGG 636
Query: 282 S-----TGTVEFVAPELTK---GAQFSFKSDIYAFGMILYFVIMGQLPFNS--------- 324
TG++ ++APE+ + ++ +SD+Y+FG+ +Y ++ LP+++
Sbjct: 637 QQQQQPTGSILWMAPEVIRMQDDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILF 696
Query: 325 --------KDMSAIKHEINELSFSPEAMSKLHDS 350
D S I+H+ +P++M KL+D+
Sbjct: 697 MVGRGYLRPDRSKIRHD------TPKSMLKLYDN 724
>CE18454 [T] KOG4717 Serine/threonine protein kinase
Length = 1016
Score = 63.5 bits (153), Expect = 6e-10
Identities = 38/125 (30%), Positives = 62/125 (49%), Gaps = 10/125 (8%)
Query: 223 IATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS 282
I T + H L ++HRDLKP N + E K + DFG S Y S
Sbjct: 133 IMTAIDYCHQLHVVHRDLKPENVVFFE--------KLGMVKLTDFGFSNSYEPGEQLNTS 184
Query: 283 TGTVEFVAPELTKGAQFSFKS-DIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFS- 340
G++ + APE+ G + + D+++ G+ILY ++ G+LPF + S +I + +S
Sbjct: 185 CGSLAYSAPEILLGDSYDAPAVDVWSLGVILYMLVCGRLPFQEANDSETLTKILDCKYSI 244
Query: 341 PEAMS 345
P+ +S
Sbjct: 245 PDVLS 249
>CE09248 [T] KOG0200 Fibroblast/platelet-derived growth factor receptor and
related receptor tyrosine kinases
Length = 478
Score = 63.5 bits (153), Expect = 6e-10
Identities = 52/214 (24%), Positives = 103/214 (47%), Gaps = 33/214 (15%)
Query: 165 FILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHK-KSRIGLTTRQIVSIANDI 223
++L +FC G+L I+ RR++++N ++ GL + ++ + I
Sbjct: 255 YLLVEFCEHGDLLHMIR--------------NRRQEIINGPTENPDGLKIKDLLMFSWQI 300
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLR-DATGS 282
+ GL+ L+++ IHRD+ N L+ D C IGDFG +L L A G
Sbjct: 301 SNGLEYLNNIGCIHRDIAARNVLV---------DSANTCKIGDFGLCRLTDSLLYTARGG 351
Query: 283 TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI-MGQLPFNSKDMSAI--KHEINELSF 339
++++APE ++S+KSD++++G++L+ + +G++P+ + + H +
Sbjct: 352 RLPLKWMAPESLATYEYSYKSDVWSYGVLLWELFSLGEVPYGEVQTTELLQTHRSGKRLL 411
Query: 340 SPE-AMSKLHDSLDLA----PIDPSLYNLVCEML 368
PE +++D + L P D + C +L
Sbjct: 412 KPEWCPEEIYDVMRLCWQELPDDRPAFQQTCAVL 445
>At4g31110 [T] KOG1187 Serine/threonine protein kinase
Length = 855
Score = 63.5 bits (153), Expect = 6e-10
Identities = 78/263 (29%), Positives = 117/263 (43%), Gaps = 66/263 (25%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEE 123
F + VLG+G + VYK ML++ T A+KK + D+ L + EV +L++
Sbjct: 416 FSENRVLGHGGQGTVYK--GMLVDGR--TVAVKKSKVIDEDK-LQEFINEVVILSQ---- 466
Query: 124 SSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQ 183
I + HV V+ L G + ++P ++ +F GNL
Sbjct: 467 ----INHRHV------VKLL------GCCLETEVP------MLVYEFIINGNL------- 497
Query: 184 VFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLR---IIHRDL 240
F I ES + G+ R IA DIA L LHS I HRD+
Sbjct: 498 -FKHIHEEES---------DDYTMLWGMRLR----IAVDIAGALSYLHSSASSPIYHRDI 543
Query: 241 KPSNCLLLEEFDRSDTDKFPKCVIGDFGESQ--LYGQLRDATGSTGTVEFVAPELTKGAQ 298
K +N LL E++ + + DFG S+ Q T +GTV +V PE + +Q
Sbjct: 544 KSTNILLDEKY---------RAKVADFGTSRSVTIDQTHWTTVISGTVGYVDPEYYQSSQ 594
Query: 299 FSFKSDIYAFGMILYFVIMGQLP 321
++ KSD+Y+FG+IL +I G P
Sbjct: 595 YTEKSDVYSFGVILAELITGDKP 617
>At3g12200 [R] KOG0589 Serine/threonine protein kinase
Length = 571
Score = 63.5 bits (153), Expect = 6e-10
Identities = 70/289 (24%), Positives = 123/289 (42%), Gaps = 63/289 (21%)
Query: 93 FALKKICIGDDMHWLYR-CLKEVKLLNRLTEESSHLITYNHVWLERCPVESLILTQNDGS 151
+A+KKIC+ L + L+E+KLL+ L ++ +++ Y W++ ND +
Sbjct: 45 YAMKKICLAKHTDKLKQTALQEMKLLSSL--KNPYIVHYEDSWID-----------NDNN 91
Query: 152 SVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGL 211
+ I + GGN+ + I+ + R KL + RI
Sbjct: 92 AC------------IFTAYYEGGNMANAIK--------------KARGKLF--PEERIFK 123
Query: 212 TTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQ 271
Q++ N LHS R++H DL SN L K +G++G ++
Sbjct: 124 WLAQLLLAVN-------YLHSNRVVHMDLTCSNIFL---------PKDDHVQLGNYGLAK 167
Query: 272 LYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIK 331
L + + +G + PE+ + + +KSDI++ G +Y + Q F + DM+ +
Sbjct: 168 LINPEKPVSMVSGISNSMCPEVLEDQPYGYKSDIWSLGCCMYEITAHQPAFKAPDMAGLI 227
Query: 332 HEINELSFSPEAM---SKLHDSLDL-APIDPSLYNLVCEMLNHTPSLRP 376
++IN SP + S L + L P CE+L + PSL+P
Sbjct: 228 NKINRSLMSPLPIVYSSTLKQMIKLMLRKKPEYRPTACELLRN-PSLQP 275
>At3g06630 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 671
Score = 63.5 bits (153), Expect = 6e-10
Identities = 46/124 (37%), Positives = 73/124 (58%), Gaps = 14/124 (11%)
Query: 205 KKSRIGLTTRQIVSIANDIATGLKQLH--SLRIIHRDLKPSNCLLLEEFDRSDTDKFPKC 262
++S L R+ +++A DIA G+ LH S IIHRDLK SN L+ DR+ T K
Sbjct: 521 QRSMSKLDWRRRINMALDIARGMNYLHCCSPPIIHRDLKSSNLLV----DRNWTVK---- 572
Query: 263 VIGDFGESQLYGQ--LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQL 320
+ DFG S++ Q L +G GT +++APE+ + KSDIY+FG++L+ + ++
Sbjct: 573 -VADFGLSRIKHQTYLTSKSGK-GTPQWMAPEVLRNESADEKSDIYSFGVVLWELATEKI 630
Query: 321 PFNS 324
P+ +
Sbjct: 631 PWEN 634
>At3g06620 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 773
Score = 63.5 bits (153), Expect = 6e-10
Identities = 55/181 (30%), Positives = 92/181 (50%), Gaps = 23/181 (12%)
Query: 205 KKSRIGLTTRQIVSIANDIATGLKQLH--SLRIIHRDLKPSNCLLLEEFDRSDTDKFPKC 262
+KS L R+ + +A DIA G+ LH S IIHRDLK SN L+ D++ T K
Sbjct: 581 QKSTSKLDWRRRIHMALDIARGMNYLHHCSPPIIHRDLKSSNLLV----DKNWTVK---- 632
Query: 263 VIGDFGESQLYGQ--LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQL 320
+ DFG S++ + L +G GT +++APE+ + KSDIY+FG++L+ + ++
Sbjct: 633 -VADFGLSRIKHETYLTSKSGK-GTPQWMAPEVLRNESADEKSDIYSFGVVLWELATEKI 690
Query: 321 PFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQ 380
P+ + + + I + F + + D IDP +L+ + LRP +
Sbjct: 691 PWETLNSMQV---IGAVGFMDQRLEIPKD------IDPRWISLMESCWHSDTKLRPTFQE 741
Query: 381 I 381
+
Sbjct: 742 L 742
>7294217 [D] KOG0588 Serine/threonine protein kinase
Length = 851
Score = 63.5 bits (153), Expect = 6e-10
Identities = 47/181 (25%), Positives = 81/181 (43%), Gaps = 24/181 (13%)
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
Y + +SG E L ++ + LT ++ I + L HS I HRDLK
Sbjct: 91 YLILEHVSGGE--------LFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLK 142
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQF-S 300
P N LL D+ I DFG + L S G+ + PE+ +G ++
Sbjct: 143 PENLLL---------DEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDG 193
Query: 301 FKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSF------SPEAMSKLHDSLDLA 354
K+D+++ G+ILY +++G LPF+ ++ + ++ F P+ S L +++
Sbjct: 194 RKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVN 253
Query: 355 P 355
P
Sbjct: 254 P 254
>CE23702 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 855
Score = 63.2 bits (152), Expect = 8e-10
Identities = 41/126 (32%), Positives = 64/126 (50%), Gaps = 10/126 (7%)
Query: 206 KSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIG 265
KSR +T +IA G+ LH ++IHRDLK N L+ E D C
Sbjct: 140 KSRNTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAE------DSIKIC--- 190
Query: 266 DFGESQLYGQLRDATGS-TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNS 324
DFG S + ++ S GTV ++APE+ K + K D+Y+FG++L+ ++ + P+ +
Sbjct: 191 DFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYAN 250
Query: 325 KDMSAI 330
AI
Sbjct: 251 IAQMAI 256
>CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 357
Score = 63.2 bits (152), Expect = 8e-10
Identities = 47/132 (35%), Positives = 69/132 (51%), Gaps = 15/132 (11%)
Query: 218 SIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQL 276
S D GL+ LH +I+HRD+KPSN LL + + I DFG S + G
Sbjct: 146 SYFRDTLCGLEYLHYQKIVHRDIKPSNLLLSD---------IGQVKIADFGVSCEFEGID 196
Query: 277 RDATGSTGTVEFVAPE-LTKGAQFSFK---SDIYAFGMILYFVIMGQLPFNSKDMSAIKH 332
+G+ GT F+APE LT+GA + DI++ G+ LY ++G +PF + A+
Sbjct: 197 AFLSGTAGTPAFMAPEALTEGANHFYSGRAQDIWSLGITLYAFVIGTVPFVDNYIIALHK 256
Query: 333 EI-NELSFSPEA 343
+I N+ PEA
Sbjct: 257 KIKNDPIVFPEA 268
>At5g19360 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 523
Score = 63.2 bits (152), Expect = 8e-10
Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 18/170 (10%)
Query: 214 RQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY 273
R S+ I + HS+ +IHRDLKP N LLL + + S DFG S Y
Sbjct: 167 RAAASLLRTIVQIIHTCHSMGVIHRDLKPENFLLLSKDENSPLK------ATDFGLSVFY 220
Query: 274 GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHE 333
G+ ++APE+ + ++ ++DI++ G++LY ++ G PF ++ + I +
Sbjct: 221 KPGEVFKDIVGSAYYIAPEVLR-RKYGPEADIWSIGVMLYILLCGVPPFWAESENGIFNA 279
Query: 334 I--NELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
I ++ FS + I P +LV +MLN P R ++Q+
Sbjct: 280 ILSGQVDFSSDPW---------PVISPQAKDLVRKMLNSDPKQRLTAAQV 320
>At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 821
Score = 63.2 bits (152), Expect = 8e-10
Identities = 43/128 (33%), Positives = 70/128 (54%), Gaps = 12/128 (9%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLR--IIHRDLKPSNCLLLEEFDRSDTD 257
+LL+ +R L R+ +S+A D+A G+ LH+ I+HRDLK N L+ D
Sbjct: 635 RLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLV---------D 685
Query: 258 KFPKCVIGDFGESQLYGQ-LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI 316
K + DFG S+L + + GT E++APE+ + + KSD+Y+FG+IL+ +
Sbjct: 686 KKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELA 745
Query: 317 MGQLPFNS 324
Q P+ +
Sbjct: 746 TLQQPWGN 753
>At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 366
Score = 63.2 bits (152), Expect = 8e-10
Identities = 36/115 (31%), Positives = 59/115 (51%), Gaps = 15/115 (13%)
Query: 214 RQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY 273
+Q+ ++ I +GL LHS I+HRD+KPSN L+ + I DFG S++
Sbjct: 171 QQLADLSRQILSGLAYLHSRHIVHRDIKPSNLLI---------NSAKNVKIADFGVSRIL 221
Query: 274 GQLRD-ATGSTGTVEFVAPE-----LTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
Q D S GT+ +++PE L +G + DI++ G+ + +G+ PF
Sbjct: 222 AQTMDPCNSSVGTIAYMSPERINTDLNQGKYDGYAGDIWSLGVSILEFYLGRFPF 276
>At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 284
Score = 63.2 bits (152), Expect = 8e-10
Identities = 38/108 (35%), Positives = 54/108 (49%), Gaps = 8/108 (7%)
Query: 215 QIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYG 274
Q S A I L H ++HRD+KP N L+ R+DT K I DFG G
Sbjct: 116 QTASFAKQILQALSHCHRYGVVHRDIKPENILVDL---RNDTVK-----ICDFGSGIWLG 167
Query: 275 QLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
+ G GT +VAPE+ G + K D+++ G++LY ++ G PF
Sbjct: 168 EGETTEGVVGTPYYVAPEVLMGYSYGEKVDLWSAGVVLYTMLAGTPPF 215
>7300551 [T] KOG1027 Serine/threonine protein kinase and endoribonuclease
ERN1/IRE1 sensor of the unfolded protein response
pathway
Length = 1009
Score = 63.2 bits (152), Expect = 8e-10
Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 19/166 (11%)
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG--ESQLYGQ- 275
+ + A+GL LHSL I+HRD+KP N L+ D + +I DFG + +G+
Sbjct: 582 VLSQAASGLSHLHSLDIVHRDIKPQNVLI----SLPDAKGKVRVMISDFGLCKKLNFGKT 637
Query: 276 -LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIM-GQLPFN---SKDMSAI 330
+G TGT ++APE+ + + + DI++ G + Y+V+ G F + + +
Sbjct: 638 SFSRRSGVTGTDGWIAPEMMRSQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANIL 697
Query: 331 KHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRP 376
HE N PE DS D I L+ +M++ P RP
Sbjct: 698 SHEYNLAKLRPE-----DDSEDSRII--LAEQLISDMIHKDPQSRP 736
>7293666 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 576
Score = 63.2 bits (152), Expect = 8e-10
Identities = 47/166 (28%), Positives = 78/166 (46%), Gaps = 13/166 (7%)
Query: 197 RRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDT 256
+++ ++ K R +T + I G+K LH RIIHRDLK N L
Sbjct: 106 KKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFL--------- 156
Query: 257 DKFPKCVIGDFGESQL--YGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYF 314
+ IGDFG + Y R T GT ++APE+ SF+ DI++ G ++Y
Sbjct: 157 NDLLHVKIGDFGLATRIEYEGERKKT-LCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYT 215
Query: 315 VIMGQLPFNSKDMSAIKHEINELSFS-PEAMSKLHDSLDLAPIDPS 359
+++GQ PF +K + +I + + P + K + +A + P+
Sbjct: 216 LLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPN 261
>CE27131_1 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 360
Score = 63.2 bits (152), Expect = 8e-10
Identities = 60/211 (28%), Positives = 99/211 (46%), Gaps = 27/211 (12%)
Query: 171 CRGGNLEDTIQYQ--VFNRISGNESRLERRKKLLN---HKKSRIGLTTRQIVSIANDIAT 225
CR +++ Y+ +F + GN+ E ++ N + + TRQ++
Sbjct: 80 CRLEKTINSVHYRHIIFENMEGNDICFEIVQRASNGFVFSEYVVSHYTRQLLD------- 132
Query: 226 GLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGE-SQLYGQLRDATGSTG 284
L H+ +I+HRD++P N L+L D S K C G + S++ G + A G G
Sbjct: 133 ALDYCHTRKIVHRDVRPHN-LVLASKDTSAPLKL--CGFGVAKDLSEIGGSM--ACGRVG 187
Query: 285 TVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAM 344
+F+APE+ + + S SDI++ G++L+ ++ G+LPF S S I I + +
Sbjct: 188 VPQFMAPEIVRKDRVSCSSDIWSSGVVLFLLLAGRLPF-SGSTSDIYERIMQTDVDVDGY 246
Query: 345 SKLHDSLDLAPIDPSLYNLVCEMLNHTPSLR 375
+ I S NLV MLN PS R
Sbjct: 247 --------MPNISESARNLVRRMLNADPSKR 269
>Hs4502435 [T] KOG0197 Tyrosine kinases
Length = 675
Score = 62.8 bits (151), Expect = 1e-09
Identities = 51/185 (27%), Positives = 94/185 (50%), Gaps = 23/185 (12%)
Query: 201 LLNHKKSR-IGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
LLN+ +S GL Q++ + D+ G+ L S + IHRDL NCL+ D D
Sbjct: 497 LLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLV-------DRDLC 549
Query: 260 PKCVIGDFGESQ--LYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI- 316
K + DFG ++ L Q + G+ V++ APE+ ++S KSD++AFG++++ V
Sbjct: 550 VK--VSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFS 607
Query: 317 MGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRP 376
+G+ P++ D S + ++++ + + H + D ++Y ++ + P RP
Sbjct: 608 LGKQPYDLYDNSQVVLKVSQ----GHRLYRPHLASD------TIYQIMYSCWHELPEKRP 657
Query: 377 DSSQI 381
Q+
Sbjct: 658 TFQQL 662
>CE28650 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 288
Score = 62.8 bits (151), Expect = 1e-09
Identities = 43/139 (30%), Positives = 71/139 (50%), Gaps = 10/139 (7%)
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCV-IGDFGESQ-LYGQL 276
+ ++IA G K L+ L+I+HRD+KP N L+ +D K C I DFG S+ L +
Sbjct: 117 LLDNIARGYKALYELKIVHRDIKPQNILI----TYTDASKQIACARITDFGISRTLDNEG 172
Query: 277 RDATGSTGTVEFVAPE----LTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKH 332
+ GT ++APE L K Q+ K D+++ G +LY + G++PF+ + +
Sbjct: 173 EELCNVAGTFYYMAPEVGANLLKTCQYDSKVDMWSIGCLLYQCVTGEVPFDECSLCKLFL 232
Query: 333 EINELSFSPEAMSKLHDSL 351
+ +F +L D L
Sbjct: 233 YVAGANFDAYDPPELPDEL 251
>CE18169 [T] KOG0603 Ribosomal protein S6 kinase
Length = 797
Score = 62.8 bits (151), Expect = 1e-09
Identities = 69/280 (24%), Positives = 117/280 (41%), Gaps = 60/280 (21%)
Query: 62 RFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLT 121
R F+ + VLG GS V+ V+ + + +A+K L + +V+ R
Sbjct: 102 RQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKV---------LKKATLKVRDRQRTK 152
Query: 122 EESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQ 181
E + L +H ++ V+ Q +G ++++ F RGG+L
Sbjct: 153 LERNILAHISHPFI----VKLHYAFQTEGK------------LYLILDFLRGGDL----- 191
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
F R+S + T + ++ L+ LHSL I++RDLK
Sbjct: 192 ---FTRLS-----------------KEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLK 231
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS-TGTVEFVAPELTKGAQFS 300
P N LL D D K + DFG S+ T S GTVE++APE+ S
Sbjct: 232 PENILL-------DADGHIK--VTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHS 282
Query: 301 FKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFS 340
+D ++ G++++ ++ G LPF +D + +I + S
Sbjct: 283 MAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLS 322
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/163 (25%), Positives = 77/163 (47%), Gaps = 36/163 (22%)
Query: 164 MFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
++++++ C GG L D KL+N K +G + +++ +I ++
Sbjct: 521 IYMIEELCEGGELLD---------------------KLVNKKS--LG-SEKEVAAIMANL 556
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGST 283
++ LHS ++ HRDL +N L F D D ++ DFG ++ Q R G
Sbjct: 557 LNAVQYLHSQQVAHRDLTAANIL----FALKDGDPSSLRIV-DFGFAK---QSRAENGML 608
Query: 284 GT----VEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
T +FVAPE+ + + D+++ G++L+ ++ G PF
Sbjct: 609 MTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPF 651
>CE13014 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 62.8 bits (151), Expect = 1e-09
Identities = 69/280 (24%), Positives = 117/280 (41%), Gaps = 60/280 (21%)
Query: 62 RFFKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLT 121
R F+ + VLG GS V+ V+ + + +A+K L + +V+ R
Sbjct: 45 RQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKV---------LKKATLKVRDRQRTK 95
Query: 122 EESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQ 181
E + L +H ++ V+ Q +G ++++ F RGG+L
Sbjct: 96 LERNILAHISHPFI----VKLHYAFQTEGK------------LYLILDFLRGGDL----- 134
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
F R+S + T + ++ L+ LHSL I++RDLK
Sbjct: 135 ---FTRLS-----------------KEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLK 174
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS-TGTVEFVAPELTKGAQFS 300
P N LL D D K + DFG S+ T S GTVE++APE+ S
Sbjct: 175 PENILL-------DADGHIK--VTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHS 225
Query: 301 FKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFS 340
+D ++ G++++ ++ G LPF +D + +I + S
Sbjct: 226 MAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLS 265
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/163 (25%), Positives = 77/163 (47%), Gaps = 36/163 (22%)
Query: 164 MFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
++++++ C GG L D KL+N K +G + +++ +I ++
Sbjct: 464 IYMIEELCEGGELLD---------------------KLVNKKS--LG-SEKEVAAIMANL 499
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGST 283
++ LHS ++ HRDL +N L F D D ++ DFG ++ Q R G
Sbjct: 500 LNAVQYLHSQQVAHRDLTAANIL----FALKDGDPSSLRIV-DFGFAK---QSRAENGML 551
Query: 284 GT----VEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
T +FVAPE+ + + D+++ G++L+ ++ G PF
Sbjct: 552 MTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPF 594
>CE11430 [T] KOG0194 Protein tyrosine kinase
Length = 585
Score = 62.8 bits (151), Expect = 1e-09
Identities = 46/152 (30%), Positives = 76/152 (49%), Gaps = 20/152 (13%)
Query: 203 NHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKC 262
NHK +T ++ A G+ LHS RI+HRDL N LL E DK PK
Sbjct: 416 NHKT----ITLADKINFVLGSARGVAYLHSQRILHRDLAVRNILLTE-------DKTPK- 463
Query: 263 VIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI-MGQLP 321
+ DFG ++L + V ++APE + F+ K+D+++FG +++ + GQ P
Sbjct: 464 -VSDFGLAELTDRYEMKEHCKIPVRYLAPETLELFIFTPKTDVFSFGCVIWEIYENGQQP 522
Query: 322 FNSKDMSAIKHEINELSF------SPEAMSKL 347
+ K+ I+ ++ + F +PEA+ +L
Sbjct: 523 HDGKNAQTIRAQVKKREFLKLSSSAPEALRRL 554
>At4g23240 [T] KOG1187 Serine/threonine protein kinase
Length = 352
Score = 62.8 bits (151), Expect = 1e-09
Identities = 46/125 (36%), Positives = 65/125 (51%), Gaps = 16/125 (12%)
Query: 201 LLNHKKSRIGLTTRQIVSIANDIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSDTD 257
L +H++ R L R +I + G+ LH L IIHRDLK N LL D D
Sbjct: 110 LFDHRR-RGQLDWRTRYNIIRGVTRGILYLHQDSRLTIIHRDLKAGNILL-------DVD 161
Query: 258 KFPKCVIGDFGESQLY--GQLRDATGST-GTVEFVAPELTKGAQFSFKSDIYAFGMILYF 314
PK I DFG ++ + Q TG GT ++ PE QFS KSD+Y+FG+++
Sbjct: 162 MNPK--IADFGVARNFRVDQTEATTGRVVGTFGYMPPEYVANGQFSMKSDVYSFGVLILE 219
Query: 315 VIMGQ 319
+I+G+
Sbjct: 220 IIVGK 224
>At3g10660 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 646
Score = 62.8 bits (151), Expect = 1e-09
Identities = 51/175 (29%), Positives = 82/175 (46%), Gaps = 24/175 (13%)
Query: 212 TTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQ 271
T R+ +A I L+ HSL ++HRDLKP N L F + D K + DFG S
Sbjct: 283 TERKAAELARTIVGVLEACHSLGVMHRDLKPENFL----FVSREEDSLLKTI--DFGLSM 336
Query: 272 LYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIK 331
+ T G+ +VAPE+ + ++ +SD+++ G+I+Y ++ G PF ++ I
Sbjct: 337 FFKPDEVFTDVVGSPYYVAPEVLR-KRYGPESDVWSAGVIVYILLSGVPPFWAETEQGIF 395
Query: 332 HEINELSFSPEAMSKLHDSLDLA-----PIDPSLYNLVCEMLNHTPSLRPDSSQI 381
++ LH LD + I S +LV +ML P R + Q+
Sbjct: 396 EQV------------LHGDLDFSSDPWPSISESAKDLVRKMLVRDPKRRLTAHQV 438
>At3g06640 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 763
Score = 62.8 bits (151), Expect = 1e-09
Identities = 55/190 (28%), Positives = 93/190 (48%), Gaps = 25/190 (13%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLH--SLRIIHRDLKPSNCLLLEEFDRSDTD 257
+LL S+ L R+ +++A DIA G+ LH S IIHRDLK SN L+ D
Sbjct: 530 RLLQRNMSK--LDWRRRINMALDIARGMNYLHRCSPPIIHRDLKSSNLLV---------D 578
Query: 258 KFPKCVIGDFGESQL--YGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFV 315
K + DFG S++ + L +G G +++APE+ + KSDIY+FG++L+ +
Sbjct: 579 KNLTVKVADFGLSRIKHHTYLTSKSGK-GMPQWMAPEVLRNESADEKSDIYSFGVVLWEL 637
Query: 316 IMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLR 375
++P+ + + + I + F + + D IDP +L+ + LR
Sbjct: 638 ATEKIPWENLNSMQV---IGAVGFMNQRLEIPKD------IDPDWISLIESCWHRDAKLR 688
Query: 376 PDSSQIEYQL 385
P ++ +L
Sbjct: 689 PTFQELMERL 698
>At1g18390 [T] KOG1187 Serine/threonine protein kinase
Length = 605
Score = 62.8 bits (151), Expect = 1e-09
Identities = 49/146 (33%), Positives = 79/146 (53%), Gaps = 17/146 (11%)
Query: 217 VSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY--G 274
+ IA + A+ LK LH+ +IIHRD+K +N LL + F+ + DFG S+L+
Sbjct: 397 LKIAVETASALKYLHASKIIHRDVKSNNILLDQNFN---------VKVADFGLSRLFPMD 447
Query: 275 QLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
+ +T GT +V P+ Q S KSD+Y+F ++L ++ LP + D++ + EI
Sbjct: 448 KTHVSTAPQGTPGYVDPDYHLCYQLSNKSDVYSFAVVL-MELISSLP--AVDITRPRQEI 504
Query: 335 NELSFSPEAMSKLHDSLDLAPIDPSL 360
N LS + H+ D+ +DPSL
Sbjct: 505 N-LSNMAVVKIQNHELRDM--VDPSL 527
>At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 307
Score = 62.8 bits (151), Expect = 1e-09
Identities = 63/262 (24%), Positives = 110/262 (41%), Gaps = 69/262 (26%)
Query: 65 KQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEES 124
+++ VLG GS +VYKV H +ALK + + + +E+++L R +S
Sbjct: 46 EKLHVLGRGSSGIVYKVHHKTTGE---IYALKSVNGDMSPAFTRQLAREMEILRRT--DS 100
Query: 125 SHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQV 184
+++ ++ E I+ + + IL ++ GGNLE
Sbjct: 101 PYVVRCQGIF------EKPIVGE----------------VSILMEYMDGGNLESL----- 133
Query: 185 FNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSN 244
R +T +Q+ + I GL LHSL+I+HRD+KP+N
Sbjct: 134 -----------------------RGAVTEKQLAGFSRQILKGLSYLHSLKIVHRDIKPAN 170
Query: 245 CLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS-TGTVEFVAPELTKGAQFS--- 300
LL + + I DFG S++ + D S GT +++PE A
Sbjct: 171 LLL---------NSRNEVKIADFGVSKIITRSLDYCNSYVGTCAYMSPERFDSAAGENSD 221
Query: 301 -FKSDIYAFGMILYFVIMGQLP 321
+ DI++FG+++ + +G P
Sbjct: 222 VYAGDIWSFGVMILELFVGHFP 243
>7304358 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 493
Score = 62.8 bits (151), Expect = 1e-09
Identities = 50/200 (25%), Positives = 86/200 (43%), Gaps = 22/200 (11%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E+ Y VF+ ++G E L +R + I + H ++
Sbjct: 82 EENYHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESVNHCHQNGVV 133
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQLRDATGSTGTVEFVAPELTK 295
HRDLKP N LL + K + DFG + ++ G + G GT +++PE+ K
Sbjct: 134 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLK 187
Query: 296 GAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAP 355
+ DI+A G+ILY +++G PF +D + +I ++ + S +
Sbjct: 188 KEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYD-------YPSPEWDT 240
Query: 356 IDPSLYNLVCEMLNHTPSLR 375
+ P NL+ +ML P+ R
Sbjct: 241 VTPEAKNLINQMLTVNPNKR 260
>7301213 [R] KOG0589 Serine/threonine protein kinase
Length = 841
Score = 62.8 bits (151), Expect = 1e-09
Identities = 39/142 (27%), Positives = 75/142 (52%), Gaps = 9/142 (6%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
+++ ++ ++ R I+++ I++ + +HS I+HRDLK +N L +R K
Sbjct: 191 QIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFL----NRRGIVK- 245
Query: 260 PKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQ 319
IGDFG S++ A GT + +PE+ +G ++ KSDI+A G IL + +
Sbjct: 246 ----IGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLK 301
Query: 320 LPFNSKDMSAIKHEINELSFSP 341
F + ++S + +I +++P
Sbjct: 302 KTFAASNLSELVTKIMAGNYTP 323
>SPACUNK12.02c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 335
Score = 62.4 bits (150), Expect = 1e-09
Identities = 41/130 (31%), Positives = 63/130 (47%), Gaps = 10/130 (7%)
Query: 225 TGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY--GQLRDATGS 282
+ +K LH I+HRDLKP N L + SD +I DFG S Y Q +
Sbjct: 140 SAVKYLHDNGIVHRDLKPENLLYRSKDPNSDL------LIADFGLSHFYEDSQYYMLMTA 193
Query: 283 TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI--NELSFS 340
GT E++APE+ + + D++A G+I YF++ G PF + I NE +F+
Sbjct: 194 CGTPEYMAPEVFRRTGYGKPVDMWAIGVITYFLLSGYTPFARPSQVEVIEAILANEYTFN 253
Query: 341 PEAMSKLHDS 350
S + ++
Sbjct: 254 DPCWSGISET 263
>Hs14768528 [T] KOG1187 Serine/threonine protein kinase
Length = 460
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/176 (30%), Positives = 86/176 (48%), Gaps = 21/176 (11%)
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG---ESQLYGQ 275
IA A G+ LH IHRD+K +N LL E F I DFG S+ + Q
Sbjct: 291 IAQGAANGINFLHENHHIHRDIKSANILLDEAFTAK---------ISDFGLARASEKFAQ 341
Query: 276 LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKD-----MSAI 330
+ GT ++APE +G + + KSDIY+FG++L +I G LP + + I
Sbjct: 342 TVMTSRIVGTTAYMAPEALRG-EITPKSDIYSFGVVLLEIITG-LPAVDEHREPQLLLDI 399
Query: 331 KHEI-NELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQIEYQL 385
K EI +E + + K + D ++ ++Y++ + L+ + RPD +++ L
Sbjct: 400 KEEIEDEEKTIEDYIDKKMNDADSTSVE-AMYSVASQCLHEKKNKRPDIKKVQQLL 454
>CE24761 [D] KOG0580 Serine/threonine protein kinase
Length = 305
Score = 62.4 bits (150), Expect = 1e-09
Identities = 38/126 (30%), Positives = 63/126 (49%), Gaps = 11/126 (8%)
Query: 222 DIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATG 281
+IA L H +IHRD+KP N L+ + + IGDFG S ++
Sbjct: 136 EIADALSYCHRKNVIHRDIKPENLLIGSQGELK---------IGDFGWS-VHAPSNKRQT 185
Query: 282 STGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFS- 340
GT++++ PE+ GA S D++A G++ Y ++G+ PF +D S I F+
Sbjct: 186 MCGTMDYLPPEMVNGADHSDAVDLWAIGVLCYEFLVGKPPFEHEDQSKTYAAIKAARFTY 245
Query: 341 PEAMSK 346
P+++ K
Sbjct: 246 PDSVKK 251
>CE01519 [T] KOG1027 Serine/threonine protein kinase and endoribonuclease
ERN1/IRE1 sensor of the unfolded protein response
pathway
Length = 983
Score = 62.4 bits (150), Expect = 1e-09
Identities = 51/174 (29%), Positives = 80/174 (45%), Gaps = 23/174 (13%)
Query: 206 KSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIG 265
+ + + R I+ A D GL LH+ +I+HRD+KP N L+ R + + VI
Sbjct: 622 QQNVTIALRDIMKQATD---GLAHLHASKIVHRDMKPQNVLITMASQRGEM----RAVIS 674
Query: 266 DFGESQLYGQLRD------ATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI-MG 318
DFG + ++ A+G GT ++APE+ A S+ DI++ G I Y+V+ G
Sbjct: 675 DFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEVLISASTSYPVDIFSLGCIFYYVLTSG 734
Query: 319 QLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTP 372
PF H + ++KL D D + D +L+ MLN P
Sbjct: 735 THPFGKS-----LHRQANIVNGEYTLNKLADLDDWSLAD----DLISSMLNVEP 779
>At4g11890 [T] KOG1187 Serine/threonine protein kinase
Length = 352
Score = 62.4 bits (150), Expect = 1e-09
Identities = 43/136 (31%), Positives = 70/136 (50%), Gaps = 12/136 (8%)
Query: 218 SIANDIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYG 274
+I + IA GL+ LH L ++HRD+KP N LL D+D PK V + + G
Sbjct: 139 NIIDGIARGLRYLHEESGLWVVHRDIKPGNILL-------DSDLKPKIVGFELARTMQQG 191
Query: 275 Q-LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHE 333
+ + T GTV ++ PE + + S KSD+YAFG+ + +I + ++ S IK+
Sbjct: 192 ENAAETTEIVGTVGYLDPEYIRSGRVSVKSDVYAFGVTILTIISRRKAWSVDGDSLIKY- 250
Query: 334 INELSFSPEAMSKLHD 349
+ EA+ +H+
Sbjct: 251 VRRCWNRGEAIDVIHE 266
>7294076 [T] KOG4278 Protein tyrosine kinase
Length = 1504
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/184 (28%), Positives = 88/184 (47%), Gaps = 41/184 (22%)
Query: 159 TTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVS 218
T P +I+ +F GNL D F R +G E+ L ++
Sbjct: 435 TREPPFYIITEFMSHGNLLD------FLRSAGRET-----------------LDAVALLY 471
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRD 278
+A IA+G+ L S IHRDL NCL+ +K K + DFG ++L +RD
Sbjct: 472 MATQIASGMSYLESRNYIHRDLAARNCLV-------GDNKLVK--VADFGLARL---MRD 519
Query: 279 AT-----GSTGTVEFVAPELTKGAQFSFKSDIYAFGMILY-FVIMGQLPFNSKDMSAIKH 332
T G+ +++ APE +FS KSD++AFG++L+ G P+ + D++ + H
Sbjct: 520 DTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYH 579
Query: 333 EINE 336
++++
Sbjct: 580 KLDK 583
>YDR523c [T] KOG0201 Serine/threonine protein kinase
Length = 490
Score = 62.0 bits (149), Expect = 2e-09
Identities = 66/269 (24%), Positives = 108/269 (39%), Gaps = 54/269 (20%)
Query: 115 KLLNRLTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPY---------MF 165
K ++R+T+E ++ V LE + +L Q + P Y M+
Sbjct: 34 KAVDRVTQE---IVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMW 90
Query: 166 ILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIAT 225
I+ ++C GG+ D ++ N GL ++ I +++
Sbjct: 91 IVMEYCGGGSCSDLLKRSYVN-----------------------GLPEEKVSFIIHEVTL 127
Query: 226 GLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGT 285
GLK LH R IHRD+K +N LL EE +GDFG S GT
Sbjct: 128 GLKYLHEQRKIHRDIKAANILLNEE---------GMVKLGDFGVSGHIRSTLKRDTFVGT 178
Query: 286 VEFVAPELT--KGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELS----- 338
++APE+ + ++ K+DI++ G+ Y ++ G P + D + + +
Sbjct: 179 PYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQ 238
Query: 339 --FSPEAMSKLHDSLDLAPID-PSLYNLV 364
FS A + L P D PS YNL+
Sbjct: 239 GPFSDAAKDFVAGCLVKTPADRPSAYNLL 267
>SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 62.0 bits (149), Expect = 2e-09
Identities = 39/111 (35%), Positives = 59/111 (53%), Gaps = 14/111 (12%)
Query: 214 RQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY 273
R + IA + +GL LH +IIHRD+KPSN LL + + + DFG S
Sbjct: 181 RPLGKIAFGVLSGLSYLHDRKIIHRDIKPSNILLTSK---------GQVKLCDFGVS--- 228
Query: 274 GQLRDATGS--TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
G+L ++ TGT ++APE G ++ SDI++ G+ L V + + PF
Sbjct: 229 GELVNSLAGTFTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNRFPF 279
>Hs5453966 [T] KOG0583 Serine/threonine protein kinase
Length = 552
Score = 62.0 bits (149), Expect = 2e-09
Identities = 65/269 (24%), Positives = 114/269 (42%), Gaps = 43/269 (15%)
Query: 80 KVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSHLITYNHVWLERCP 139
K+ H +L + LG K+ IG+ H L VK+LNR S ++ ++R
Sbjct: 12 KIGHYVLGDTLGVGTFGKVKIGE--HQLTGHKVAVKILNRQKIRSLDVVGK----IKR-E 64
Query: 140 VESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRK 199
+++L L ++ + +T F++ ++ GG L D I G +E R+
Sbjct: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH------GRVEEMEARR 118
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
+ I + + H ++HRDLKP N LL D
Sbjct: 119 -------------------LFQQILSAVDYCHRHMVVHRDLKPENVLL---------DAH 150
Query: 260 PKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKS-DIYAFGMILYFVIMG 318
I DFG S + S G+ + APE+ G ++ DI++ G+ILY ++ G
Sbjct: 151 MNAKIADFGLSNMMSDGEFLRTSCGSPNYTAPEVISGRLYAGPEVDIWSCGVILYALLCG 210
Query: 319 QLPFNSKDMSAIKHEI-NELSFSPEAMSK 346
LPF+ + + + +I + + PE +++
Sbjct: 211 TLPFDDEHVPTLFKKIRGGVFYIPEYLNR 239
>Hs4759178 [D] KOG0580 Serine/threonine protein kinase
Length = 344
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/168 (26%), Positives = 78/168 (46%), Gaps = 21/168 (12%)
Query: 214 RQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY 273
++ +I ++A L H ++IHRD+KP N LL + + I DFG S
Sbjct: 175 QRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELK---------IADFGWSVHA 225
Query: 274 GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHE 333
LR T GT++++ PE+ +G + K D++ G++ Y +++G PF S +
Sbjct: 226 PSLRRKT-MCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRR 284
Query: 334 INELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
I ++ D A + +L+ ++L H PS R +Q+
Sbjct: 285 IVKV-----------DLKFPASVPTGAQDLISKLLRHNPSERLPLAQV 321
>Hs20545245 [D] KOG0588 Serine/threonine protein kinase
Length = 795
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/183 (26%), Positives = 85/183 (45%), Gaps = 28/183 (15%)
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
Y V +SG E L ++ + LT ++ I + L HS I HRDLK
Sbjct: 124 YLVLEHVSGGE--------LFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLK 175
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDA--TGSTGTVEFVAPELTKGAQF 299
P N LL D+ I DFG + L Q+ D+ S G+ + PE+ KG ++
Sbjct: 176 PENLLL---------DEKNNIRIADFGMASL--QVGDSLLETSCGSPHYACPEVIKGEKY 224
Query: 300 -SFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSF------SPEAMSKLHDSLD 352
++D+++ G+IL+ +++G LPF+ ++ + ++ F P+ S L ++
Sbjct: 225 DGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIE 284
Query: 353 LAP 355
+ P
Sbjct: 285 VEP 287
>Hs14042966 [T] KOG0583 Serine/threonine protein kinase
Length = 273
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/160 (26%), Positives = 73/160 (45%), Gaps = 18/160 (11%)
Query: 223 IATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS 282
IA ++ LH ++HRDLK N LL + R F FG Q +G +T
Sbjct: 119 IAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDF------GFGR-QAHGYPDLSTTY 171
Query: 283 TGTVEFVAPELTKGAQFSFKS-DIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSP 341
G+ + +PE+ G + K D+++ G++LY ++ G +PF+ D++ + P
Sbjct: 172 CGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYP 231
Query: 342 EAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
E + + L+ E+L +PS RP + Q+
Sbjct: 232 EGLE----------LSERCKALIAELLQFSPSARPSAGQV 261
>ECU11g1500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 300
Score = 62.0 bits (149), Expect = 2e-09
Identities = 45/174 (25%), Positives = 81/174 (45%), Gaps = 29/174 (16%)
Query: 155 MDIPTTMPYMFILQQFCRGGNLEDTIQYQVFN--RISGNESRLERRKKLLNHKKSRIGLT 212
+D T + I+ ++ G+L + I+Y + N R++G+
Sbjct: 78 LDFFPTKSGLSIILEYLNYGSLHEMIEYLMENGYRVAGD--------------------- 116
Query: 213 TRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEF-DRSDTDKFPKCVIGDFGESQ 271
+ S+ A GL+ LHS +IIHRD+KPSN L+ + + +F C DF ++
Sbjct: 117 --LVWSVLAQAADGLRYLHSKQIIHRDVKPSNILMNRTLVQKEELLEFKLC---DFSLAK 171
Query: 272 LYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSK 325
G GT ++APE+ G ++S DI++ G+ +Y ++ + PF +
Sbjct: 172 NLCGKESVCGIVGTPSYMAPEVVSGERYSTSVDIWSLGISIYELLTLRRPFEGR 225
>CE28061 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 302
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE28060 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 302
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE28059 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 350
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE28058 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 571
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE28057 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 520
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE28056 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 518
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE28055 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 533
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE28054 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 482
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE28053 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 720
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE28051 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 559
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 21/204 (10%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E++ Y VF+ ++G E L +R + I + HS I+
Sbjct: 80 EESFHYLVFDLVTGGE--------LFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKG 296
HRDLKP N LL + K + DFG + G GT +++PE+ K
Sbjct: 132 HRDLKPENLLLASKA------KGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 185
Query: 297 AQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI 356
+S DI+A G+ILY +++G PF +D + +I ++ + S + +
Sbjct: 186 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYD-------YPSPEWDTV 238
Query: 357 DPSLYNLVCEMLNHTPSLRPDSSQ 380
P +L+ ML P R + Q
Sbjct: 239 TPEAKSLIDSMLTVNPKKRITADQ 262
>CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 525
Score = 62.0 bits (149), Expect = 2e-09
Identities = 65/268 (24%), Positives = 114/268 (42%), Gaps = 74/268 (27%)
Query: 61 QRFFKQVGVLGNGSRAVVYKVKHMLLENELG-TFALKKICIGDDMHWLYRCLKEVKLLNR 119
+ F VG LG GS V+K H E G A+KK+ + D L +KE+ ++ +
Sbjct: 60 EEVFDIVGKLGEGSYGSVHKAIH----RESGHVLAIKKVPVDTD---LQEIIKEISIMQQ 112
Query: 120 LTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDT 179
+S +++ Y + + ++I+ ++C G++ D
Sbjct: 113 C--KSKYVVKYYGSYFKHSD------------------------LWIVMEYCGAGSISDI 146
Query: 180 IQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRD 239
++ RRK L + ++I ++ D GL+ LH L+ IHRD
Sbjct: 147 MR--------------ARRKPL----------SEQEISAVLRDTLKGLQYLHDLKKIHRD 182
Query: 240 LKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS----TGTVEFVAPELTK 295
+K N LL +TD K + DFG + GQL D GT ++APE+ +
Sbjct: 183 IKAGNILL-------NTDGIAK--LADFG---VAGQLTDTMAKRNTVIGTPFWMAPEVIE 230
Query: 296 GAQFSFKSDIYAFGMILYFVIMGQLPFN 323
+ K+DI++ G+ + G+ P++
Sbjct: 231 EIGYDTKADIWSLGITAIEMAEGRPPYS 258
>CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 640
Score = 62.0 bits (149), Expect = 2e-09
Identities = 65/268 (24%), Positives = 114/268 (42%), Gaps = 74/268 (27%)
Query: 61 QRFFKQVGVLGNGSRAVVYKVKHMLLENELG-TFALKKICIGDDMHWLYRCLKEVKLLNR 119
+ F VG LG GS V+K H E G A+KK+ + D L +KE+ ++ +
Sbjct: 32 EEVFDIVGKLGEGSYGSVHKAIH----RESGHVLAIKKVPVDTD---LQEIIKEISIMQQ 84
Query: 120 LTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDT 179
+S +++ Y + + ++I+ ++C G++ D
Sbjct: 85 C--KSKYVVKYYGSYFKHSD------------------------LWIVMEYCGAGSISDI 118
Query: 180 IQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRD 239
++ RRK L + ++I ++ D GL+ LH L+ IHRD
Sbjct: 119 MR--------------ARRKPL----------SEQEISAVLRDTLKGLQYLHDLKKIHRD 154
Query: 240 LKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS----TGTVEFVAPELTK 295
+K N LL +TD K + DFG + GQL D GT ++APE+ +
Sbjct: 155 IKAGNILL-------NTDGIAK--LADFG---VAGQLTDTMAKRNTVIGTPFWMAPEVIE 202
Query: 296 GAQFSFKSDIYAFGMILYFVIMGQLPFN 323
+ K+DI++ G+ + G+ P++
Sbjct: 203 EIGYDTKADIWSLGITAIEMAEGRPPYS 230
>CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 421
Score = 62.0 bits (149), Expect = 2e-09
Identities = 65/268 (24%), Positives = 114/268 (42%), Gaps = 74/268 (27%)
Query: 61 QRFFKQVGVLGNGSRAVVYKVKHMLLENELG-TFALKKICIGDDMHWLYRCLKEVKLLNR 119
+ F VG LG GS V+K H E G A+KK+ + D L +KE+ ++ +
Sbjct: 32 EEVFDIVGKLGEGSYGSVHKAIH----RESGHVLAIKKVPVDTD---LQEIIKEISIMQQ 84
Query: 120 LTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDT 179
+S +++ Y + + ++I+ ++C G++ D
Sbjct: 85 C--KSKYVVKYYGSYFKHSD------------------------LWIVMEYCGAGSISDI 118
Query: 180 IQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRD 239
++ RRK L + ++I ++ D GL+ LH L+ IHRD
Sbjct: 119 MR--------------ARRKPL----------SEQEISAVLRDTLKGLQYLHDLKKIHRD 154
Query: 240 LKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS----TGTVEFVAPELTK 295
+K N LL +TD K + DFG + GQL D GT ++APE+ +
Sbjct: 155 IKAGNILL-------NTDGIAK--LADFG---VAGQLTDTMAKRNTVIGTPFWMAPEVIE 202
Query: 296 GAQFSFKSDIYAFGMILYFVIMGQLPFN 323
+ K+DI++ G+ + G+ P++
Sbjct: 203 EIGYDTKADIWSLGITAIEMAEGRPPYS 230
>CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 523
Score = 62.0 bits (149), Expect = 2e-09
Identities = 65/268 (24%), Positives = 114/268 (42%), Gaps = 74/268 (27%)
Query: 61 QRFFKQVGVLGNGSRAVVYKVKHMLLENELG-TFALKKICIGDDMHWLYRCLKEVKLLNR 119
+ F VG LG GS V+K H E G A+KK+ + D L +KE+ ++ +
Sbjct: 60 EEVFDIVGKLGEGSYGSVHKAIH----RESGHVLAIKKVPVDTD---LQEIIKEISIMQQ 112
Query: 120 LTEESSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDT 179
+S +++ Y + + ++I+ ++C G++ D
Sbjct: 113 C--KSKYVVKYYGSYFKHSD------------------------LWIVMEYCGAGSISDI 146
Query: 180 IQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRD 239
++ RRK L + ++I ++ D GL+ LH L+ IHRD
Sbjct: 147 MR--------------ARRKPL----------SEQEISAVLRDTLKGLQYLHDLKKIHRD 182
Query: 240 LKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS----TGTVEFVAPELTK 295
+K N LL +TD K + DFG + GQL D GT ++APE+ +
Sbjct: 183 IKAGNILL-------NTDGIAK--LADFG---VAGQLTDTMAKRNTVIGTPFWMAPEVIE 230
Query: 296 GAQFSFKSDIYAFGMILYFVIMGQLPFN 323
+ K+DI++ G+ + G+ P++
Sbjct: 231 EIGYDTKADIWSLGITAIEMAEGRPPYS 258
>CE05507 [T] KOG0603 Ribosomal protein S6 kinase
Length = 785
Score = 62.0 bits (149), Expect = 2e-09
Identities = 64/256 (25%), Positives = 105/256 (41%), Gaps = 56/256 (21%)
Query: 182 YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLK 241
Y V ++GNE LER +KL +S RQ+VS +K LH RI+HRDLK
Sbjct: 451 YLVMEILTGNEL-LERIRKLERFTESEAADIMRQLVS-------AVKYLHDKRIVHRDLK 502
Query: 242 PSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQ-----------LRDATGSTG------ 284
P N +L E D S + + DFG ++L LR G
Sbjct: 503 PEN-ILFESIDSS-----ARLRLVDFGFARLLPNSMEQQLKSVQVLRKMYGLIAHNHSLH 556
Query: 285 ------TVEFVAPELT----KGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
T+++ APE+ +++ + D+++ G++L+ ++ GQ+PF+++ EI
Sbjct: 557 SETPCFTLQYAAPEVLDVGDSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQESATEI 616
Query: 335 ------NELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQIEYQLXXX 388
E SF+ +A + + NL+ +L P R ++ +
Sbjct: 617 MQRICRAEFSFTGDAWTN---------VSADAKNLITGLLTVDPKKRLSMQELTAHMWLK 667
Query: 389 XXXXXXXXXQEPEIRP 404
Q P I P
Sbjct: 668 SSASMDTPLQTPSILP 683
>At5g60550 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 407
Score = 62.0 bits (149), Expect = 2e-09
Identities = 43/103 (41%), Positives = 56/103 (53%), Gaps = 11/103 (10%)
Query: 222 DIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRD-AT 280
DI TGL LH+ +IH D+KP N L+ S T K IGDF SQ++ D
Sbjct: 223 DIVTGLMYLHAHDVIHGDIKPDNLLVTS----SGTVK-----IGDFSVSQVFKDDDDQLR 273
Query: 281 GSTGTVEFVAPELTKGAQFSFK-SDIYAFGMILYFVIMGQLPF 322
S GT F APE G +S + +D +A G+ LY +I+GQ PF
Sbjct: 274 RSPGTPVFTAPECCLGITYSGRAADTWAVGVTLYCMILGQYPF 316
>At5g38210 [T] KOG1187 Serine/threonine protein kinase
Length = 960
Score = 62.0 bits (149), Expect = 2e-09
Identities = 51/179 (28%), Positives = 88/179 (48%), Gaps = 26/179 (14%)
Query: 217 VSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY--G 274
+ IA + A+ L LH+ IIHRD+K +N LL D + + DFG S+L+
Sbjct: 734 LQIAIETASALSYLHASGIIHRDVKTTNILL---------DSNYQVKVADFGLSRLFPMD 784
Query: 275 QLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
Q +T GT +V PE + + + KSD+Y+FG++L +I + + D++ +H+I
Sbjct: 785 QTHISTAPQGTPGYVDPEYYQCYRLNEKSDVYSFGVVLSELISSK---EAVDITRHRHDI 841
Query: 335 N--ELSFSPEAMSKLHDSLDLA---PIDPSLYNLVCEM-------LNHTPSLRPDSSQI 381
N ++ S +H+ DL+ DPS+ ++ + L +RP +I
Sbjct: 842 NLANMAISKIQNDAVHELADLSLGFARDPSVKKMMSSVAELAFRCLQQERDVRPSMDEI 900
>At1g66880 [T] KOG1187 Serine/threonine protein kinase
Length = 1286
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/140 (31%), Positives = 76/140 (53%), Gaps = 16/140 (11%)
Query: 217 VSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLY--G 274
++IA + A+ L LH IIHRD+K +N LL + + + + DFG S+L+
Sbjct: 1059 LNIAIETASALSFLHIKGIIHRDIKTTNILLDDNY---------QVKVADFGLSRLFPMD 1109
Query: 275 QLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
Q +T GT +V PE + Q + KSD+Y+FG++L +I + + D++ +H+I
Sbjct: 1110 QTHISTAPQGTPGYVDPEYYQCYQLNEKSDVYSFGVVLTELISSK---EAVDITRHRHDI 1166
Query: 335 N--ELSFSPEAMSKLHDSLD 352
N ++ S + LH+ +D
Sbjct: 1167 NLANMAVSKIQNNALHELVD 1186
>At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 269
Score = 62.0 bits (149), Expect = 2e-09
Identities = 45/142 (31%), Positives = 69/142 (47%), Gaps = 11/142 (7%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
L Q+ +IA + L LHS RIIHRD+KP N L+ + DFG +
Sbjct: 99 LPEEQVQAIAKQLVKALDYLHSNRIIHRDMKPQNILI---------GAGSVVKLCDFGFA 149
Query: 271 QLYGQLRDATGS-TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSA 329
+ S GT ++APEL K + D+++ G+ILY + +GQ PF + + A
Sbjct: 150 RAMSTNTVVLRSIKGTPLYMAPELVKEQPYDRTVDLWSLGVILYELYVGQPPFYTNSVYA 209
Query: 330 -IKHEINELSFSPEAMSKLHDS 350
I+H + + P+ MS +S
Sbjct: 210 LIRHIVKDPVKYPDEMSTYFES 231
>Hs6005922_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 302
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/170 (27%), Positives = 72/170 (42%), Gaps = 15/170 (8%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
LT +I + ++ ++ LH+ RI H DLKP N L+ E + P + DFG++
Sbjct: 92 LTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAK------PTIKLADFGDA 145
Query: 271 QLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAI 330
G EF APE+ G S SD ++ G++ Y ++ G PF +
Sbjct: 146 VQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEET 205
Query: 331 KHEINELSFS-PEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSS 379
I L FS P+ K + VC +L P+ RP ++
Sbjct: 206 CLNICRLDFSFPDDYFK--------GVSQKAKEFVCFLLQEDPAKRPSAA 247
>Hs20127418 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 664
Score = 61.6 bits (148), Expect = 2e-09
Identities = 49/200 (24%), Positives = 86/200 (42%), Gaps = 22/200 (11%)
Query: 177 EDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRII 236
E+ Y VF+ ++G E L +R + I + H + ++
Sbjct: 82 EEGFHYLVFDLVTGGE--------LFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 237 HRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQLRDATGSTGTVEFVAPELTK 295
HRDLKP N LL + K + DFG + ++ G + G GT +++PE+ +
Sbjct: 134 HRDLKPENLLLASKC------KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 296 GAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAP 355
+ DI+A G+ILY +++G PF +D + +I ++ S +
Sbjct: 188 KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYD-------FPSPEWDT 240
Query: 356 IDPSLYNLVCEMLNHTPSLR 375
+ P NL+ +ML P+ R
Sbjct: 241 VTPEAKNLINQMLTINPAKR 260
>Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 576
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/158 (28%), Positives = 73/158 (45%), Gaps = 16/158 (10%)
Query: 222 DIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATG 281
D+ L +H I+HRDLKP N L+ D+S T K + DFG ++ +R
Sbjct: 388 DLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLK-----LADFGLAKHV--VRPIFT 440
Query: 282 STGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNS--KDMSAIKH--EINEL 337
GT +VAPE+ + + D++A G+ILY ++ G PF S +D + + ++
Sbjct: 441 VCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHF 500
Query: 338 SFSPEAMSKLHDSLD-----LAPIDPSLYNLVCEMLNH 370
F P + D+ L +DP ++L H
Sbjct: 501 EFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQH 538
>CE02586 [T] KOG0696 Serine/threonine protein kinase
Length = 861
Score = 61.6 bits (148), Expect = 2e-09
Identities = 47/133 (35%), Positives = 70/133 (52%), Gaps = 13/133 (9%)
Query: 217 VSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQL 276
V A +IA GL LHS II+RDLK N +L + TD F C FG
Sbjct: 515 VFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLERDGHIKITD-FGMCKENIFG-------- 565
Query: 277 RDATGST--GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
DAT T GT +++APE+ + D +A+G++L+ ++ GQ PF+ +D + I
Sbjct: 566 -DATTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLFEMLAGQPPFDGEDEDELFTAI 624
Query: 335 NELSFS-PEAMSK 346
E + S P+++SK
Sbjct: 625 TEHNVSYPKSLSK 637
>At5g35410 [T] KOG0583 Serine/threonine protein kinase
Length = 446
Score = 61.6 bits (148), Expect = 2e-09
Identities = 51/179 (28%), Positives = 81/179 (44%), Gaps = 36/179 (20%)
Query: 164 MFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
++I+ +F GG L D I ++ R+ +ESR +
Sbjct: 84 IYIVLEFVTGGELFDRIVHK--GRLEESESR-----------------------KYFQQL 118
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGST 283
+ H + HRDLKP N LL DT+ K + DFG S L + + +T
Sbjct: 119 VDAVAHCHCKGVYHRDLKPENLLL-------DTNGNLK--VSDFGLSALPQEGVELLRTT 169
Query: 284 -GTVEFVAPELTKGAQFSFKS-DIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFS 340
GT +VAPE+ G + + DI++ G+IL+ ++ G LPF+ D+ + +IN FS
Sbjct: 170 CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFS 228
>At4g33430 [T] KOG1187 Serine/threonine protein kinase
Length = 523
Score = 61.6 bits (148), Expect = 2e-09
Identities = 41/110 (37%), Positives = 59/110 (53%), Gaps = 14/110 (12%)
Query: 219 IANDIATGLKQLHSL---RIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQL--Y 273
IA A GL LH +IIHRD+K +N LL EEF+ V+GDFG ++L Y
Sbjct: 301 IALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFE---------AVVGDFGLAKLMDY 351
Query: 274 GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFN 323
T GT+ +APE + S K+D++ +G++L +I GQ F+
Sbjct: 352 KDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFD 401
>At1g68690 [T] KOG1187 Serine/threonine protein kinase
Length = 708
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/128 (35%), Positives = 66/128 (51%), Gaps = 16/128 (12%)
Query: 202 LNHKKSRIGLTTRQIVSIANDIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSDTDK 258
L+ +KS + TR V IA A GL LH RIIHRD+K SN LL + FD
Sbjct: 462 LHGEKSVLDWATR--VKIAAGAARGLAYLHEDCHPRIIHRDIKSSNILLEDNFDAR---- 515
Query: 259 FPKCVIGDFGESQLYGQLRD--ATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVI 316
+ DFG ++L T GT ++APE + + KSD+++FG++L +I
Sbjct: 516 -----VSDFGLARLALDCNTHITTRVIGTFGYMAPEYASSGKLTEKSDVFSFGVVLLELI 570
Query: 317 MGQLPFNS 324
G+ P ++
Sbjct: 571 TGRKPVDT 578
>At1g55200 [T] KOG1187 Serine/threonine protein kinase
Length = 676
Score = 61.6 bits (148), Expect = 2e-09
Identities = 44/150 (29%), Positives = 75/150 (49%), Gaps = 21/150 (14%)
Query: 176 LEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLR- 234
+EDT + V+ I L K +G RQ +++ A GL+ LH
Sbjct: 443 IEDTRRLLVYEYICNGSLD----SHLYGRHKDTLGWPARQKIAVG--AARGLRYLHEECR 496
Query: 235 ---IIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES--QLYGQLRDATGSTGTVEFV 289
I+HRD++P+N L+ +++ ++GDFG + Q G+L T GT ++
Sbjct: 497 VGCIVHRDMRPNNILITHDYEP---------LVGDFGLARWQPDGELGVDTRVIGTFGYL 547
Query: 290 APELTKGAQFSFKSDIYAFGMILYFVIMGQ 319
APE + Q + K+D+Y+FG++L +I G+
Sbjct: 548 APEYAQSGQITEKADVYSFGVVLIELITGR 577
>YLR248w [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 610
Score = 61.2 bits (147), Expect = 3e-09
Identities = 52/189 (27%), Positives = 82/189 (42%), Gaps = 37/189 (19%)
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLE--EFDRSDTDKFPKC-------------- 262
+ +A +K +HSL ++HRD+KP N LL E EF RS K K
Sbjct: 293 VIKQLALAVKHMHSLGVVHRDIKPEN-LLFEPIEFTRSIKPKLRKSDDPQTKADEGIFTP 351
Query: 263 ----------VIGDFGES-QLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMI 311
+ DFG S Q++ ++ GTV + APE+ K +S K D++ G +
Sbjct: 352 GVGGGGIGIVKLADFGLSKQIFS--KNTKTPCGTVGYTAPEVVKDEHYSMKVDMWGIGCV 409
Query: 312 LYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHT 371
LY ++ G PF + + + +I+ ++ + D I N V ++L
Sbjct: 410 LYTMLCGFPPFYDEKIDTLTEKISRGEYT--FLKPWWDE-----ISAGAKNAVAKLLELE 462
Query: 372 PSLRPDSSQ 380
PS R D Q
Sbjct: 463 PSKRYDIDQ 471
>YGL158w [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 512
Score = 61.2 bits (147), Expect = 3e-09
Identities = 51/177 (28%), Positives = 83/177 (46%), Gaps = 29/177 (16%)
Query: 219 IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEF-------DRSDTDKFPKCVIG------ 265
+ +A +K +H + I+HRD+KP N LL E D D+F V G
Sbjct: 239 VITQVAIAIKHMHYMGIVHRDVKPEN-LLFEPIPFYGLDGDMQKEDEFTLGVGGGGIGLV 297
Query: 266 ---DFGESQLYGQLRDATGST--GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQL 320
DFG L +LR+ T T GT+E+VA E+ ++S K D+++ G +L+ ++ G
Sbjct: 298 KLMDFG---LAKKLRNNTAKTPCGTIEYVASEVFTSKRYSMKVDMWSIGCVLFTLLCGYP 354
Query: 321 PFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPD 377
PF K+ + +I+ + E ++ D+ I N V +L P+ R D
Sbjct: 355 PFYEKNEKTLLKKISRGDY--EFLAPWWDN-----ISSGAKNAVTHLLEVDPNKRYD 404
>Hs4505055 [T] KOG0197 Tyrosine kinases
Length = 512
Score = 61.2 bits (147), Expect = 3e-09
Identities = 48/186 (25%), Positives = 85/186 (44%), Gaps = 23/186 (12%)
Query: 151 SSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLE---------RRKKL 201
+S + + T P +Q F NL T+Q+ R+ +R E + L
Sbjct: 268 NSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSL 327
Query: 202 LNHKKSRIG--LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
L+ KS G + +++ + IA G+ + IHRDL+ +N L+ E
Sbjct: 328 LDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESL-------- 379
Query: 260 PKCVIGDFGESQLY--GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILY-FVI 316
C I DFG +++ + G+ +++ APE F+ KSD+++FG++LY V
Sbjct: 380 -MCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVT 438
Query: 317 MGQLPF 322
G++P+
Sbjct: 439 YGKIPY 444
>Hs4502193 [T] KOG0193 Serine/threonine protein kinase RAF
Length = 606
Score = 61.2 bits (147), Expect = 3e-09
Identities = 37/115 (32%), Positives = 63/115 (54%), Gaps = 15/115 (13%)
Query: 215 QIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQL-- 272
Q++ +A A G+ LH+ IIHRDLK +N L E IGDFG + +
Sbjct: 405 QLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL---------TVKIGDFGLATVKT 455
Query: 273 -YGQLRDATGSTGTVEFVAPELTKGAQ---FSFKSDIYAFGMILYFVIMGQLPFN 323
+ + +G+V ++A E+ + +SF+SD+YA+G++LY ++ G LP++
Sbjct: 456 RWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS 510
>Hs22046122 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 341
Score = 61.2 bits (147), Expect = 3e-09
Identities = 83/354 (23%), Positives = 154/354 (43%), Gaps = 76/354 (21%)
Query: 70 LGNGSRAVVYKVKHMLLENELGTFALKKI-CIGDDMHWLYRCLKEVKLLNRLTEESSHLI 128
+G GS VVY+ ++ A+KKI C + L L+E L+ + + ++I
Sbjct: 14 VGRGSYGVVYEA---VIRKTSARVAVKKIRCHAPENVEL--ALREFWALSSIKSQHPNVI 68
Query: 129 TYNHVWLERCPVESLILTQNDGSSVNMDI--------------PTTMPYMFILQQFCRGG 174
L++ + ++ + GS+ ++ + P + Y++ + FC GG
Sbjct: 69 HLEECILQK---DGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
Query: 175 NLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLR 234
++ + LL+ K +R + S +++ L LH +
Sbjct: 126 DMNEY---------------------LLSRKPNR-----KTNTSFMLQLSSALAFLHKNQ 159
Query: 235 IIHRDLKPSNCLLLE-EFDRSDTDKFPKCVIGDFGESQL---YGQLRDATGST------- 283
IIHRDLKP N L+ + D SD + P + DFG S++ GQ + S
Sbjct: 160 IIHRDLKPDNILISQTRLDTSDLE--PTLKVADFGLSKVCSASGQNPEEPVSVNKCFLST 217
Query: 284 --GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKD-----MSAIKHEINE 336
GT ++APE+ +G ++ K+DI+A G+I++ ++ ++ F + + + + E
Sbjct: 218 ACGTDFYMAPEVWEG-HYTAKADIFALGIIIW-AMLERITFIDTETKKELLGSYVKQGTE 275
Query: 337 LSFSPEAMSKLHDSLDLAPIDPSLYN-----LVCEMLNHTPSLRPDSSQIEYQL 385
+ EA+ + L P+ N L+ EML P RPD+ ++E +L
Sbjct: 276 IVPVGEALLENPKMELLIPVKKKSMNGRMKQLIKEMLAANPQDRPDAFELELRL 329
>Hs20547806 [R] KOG0589 Serine/threonine protein kinase
Length = 489
Score = 61.2 bits (147), Expect = 3e-09
Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 43/220 (19%)
Query: 163 YMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIAND 222
+++I+ ++C GG+L I+ Q + +L +LN
Sbjct: 74 HLYIVMEYCDGGDLMQKIKQQ--------KGKLFPEDMILNW---------------FTQ 110
Query: 223 IATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQ-LRDATG 281
+ G+ +H R++HRD+K N L + K +GDFG ++L + A
Sbjct: 111 MCLGVNHIHKKRVLHRDIKSKNIFLTQN---------GKVKLGDFGSARLLSNPMAFACT 161
Query: 282 STGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSP 341
GT +V PE+ + ++ KSDI++ G ILY + + PF + + ++ + SP
Sbjct: 162 YVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISP 221
Query: 342 EAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
++ L LV +M PS RP ++ +
Sbjct: 222 LPSHYSYE----------LQFLVKQMFKRNPSHRPSATTL 251
>Hs18594815 [T] KOG0193 Serine/threonine protein kinase RAF
Length = 609
Score = 61.2 bits (147), Expect = 3e-09
Identities = 37/115 (32%), Positives = 63/115 (54%), Gaps = 15/115 (13%)
Query: 215 QIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQL-- 272
Q++ +A A G+ LH+ IIHRDLK +N L E IGDFG + +
Sbjct: 408 QLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL---------TVKIGDFGLATVKT 458
Query: 273 -YGQLRDATGSTGTVEFVAPELTKGAQ---FSFKSDIYAFGMILYFVIMGQLPFN 323
+ + +G+V ++A E+ + +SF+SD+YA+G++LY ++ G LP++
Sbjct: 459 RWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYS 513
>Hs17933758 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 588
Score = 61.2 bits (147), Expect = 3e-09
Identities = 49/158 (31%), Positives = 75/158 (47%), Gaps = 22/158 (13%)
Query: 222 DIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES-QLYGQLRDAT 280
D+ G++ LH +IIHRD+KPSN L+ E+ I DFG S + G +
Sbjct: 295 DLIKGIEYLHYQKIIHRDIKPSNLLVGED---------GHIKIADFGVSNEFKGSDALLS 345
Query: 281 GSTGTVEFVAPELTKGAQ--FSFKS-DIYAFGMILYFVIMGQLPFNSKDMSAIKHEINEL 337
+ GT F+APE + FS K+ D++A G+ LY + GQ PF + + + +I
Sbjct: 346 NTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIK-- 403
Query: 338 SFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLR 375
S+ + D I L +L+ ML+ P R
Sbjct: 404 -------SQALEFPDQPDIAEDLKDLITRMLDKNPESR 434
>CE09689 [T] KOG0194 Protein tyrosine kinase
Length = 379
Score = 61.2 bits (147), Expect = 3e-09
Identities = 46/167 (27%), Positives = 77/167 (45%), Gaps = 35/167 (20%)
Query: 157 IPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQI 216
+ T + I+ + C GG L+ SR+E++ + L+ R
Sbjct: 169 VATQQEPIMIVMELCSGGCLK---------------SRIEKKDEQLSDVLKR-------- 205
Query: 217 VSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQL 276
IA G++ L ++IHRDL N LL DK C I DFG S L+G+L
Sbjct: 206 -KYCKQIAKGMRYLEKKQVIHRDLAARNVLL---------DKSDNCKISDFGLS-LFGKL 254
Query: 277 -RDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
++ + ++APE +S KSD+++FG++++ V G+ P+
Sbjct: 255 HKEQKLMKVPIRWLAPETLLKGIYSSKSDVWSFGVVMFEVFSGEYPY 301
>At1g73660 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 1030
Score = 61.2 bits (147), Expect = 3e-09
Identities = 48/175 (27%), Positives = 84/175 (47%), Gaps = 23/175 (13%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLR--IIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG 268
L R+ + +A D A G+ LHS I+HRDLK N L+ DK + DFG
Sbjct: 841 LDERRRLRMALDAARGMNYLHSCNPMIVHRDLKSPNLLV---------DKNWVVKVCDFG 891
Query: 269 ESQL-YGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDM 327
S++ + + + GT E++APE+ + K D+Y++G+IL+ + Q P+ +
Sbjct: 892 LSRMKHSTYLSSKSTAGTAEWMAPEVLRNEPADEKCDVYSYGVILWELFTLQQPWGKMNP 951
Query: 328 SAIKHEINELSFSPEAMSKLHDSLDLAP-IDPSLYNLVCEMLNHTPSLRPDSSQI 381
+ + + F H LD+ +DP++ +L+ + LRP ++I
Sbjct: 952 MQV---VGAVGFQ-------HRRLDIPDFVDPAIADLISKCWQTDSKLRPSFAEI 996
>YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 842
Score = 60.8 bits (146), Expect = 4e-09
Identities = 45/164 (27%), Positives = 74/164 (44%), Gaps = 28/164 (17%)
Query: 164 MFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
++++ +F GG+L D I+ N S LT QI I +
Sbjct: 636 LWVVMEFMEGGSLTDIIENSPTN------------------DNSHSPLTEPQIAYIVRET 677
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGE-SQLYGQLRDATGS 282
GLK LH IIHRD+K N LL D + I DFG ++L +
Sbjct: 678 CQGLKFLHDKHIIHRDIKSDNVLL---------DTRARVKITDFGFCARLTDKRSKRATM 728
Query: 283 TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKD 326
GT ++APE+ K ++ K D+++ G++ ++ G+ P+ ++D
Sbjct: 729 VGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNED 772
>YJL187c [D] KOG0601 Cyclin-dependent kinase WEE1
Length = 819
Score = 60.8 bits (146), Expect = 4e-09
Identities = 56/253 (22%), Positives = 108/253 (42%), Gaps = 57/253 (22%)
Query: 64 FKQVGVLGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEE 123
F V +G G + VY+V + A+K + + L R L E+K+LN +T +
Sbjct: 444 FTNVHSIGKGQFSTVYQVTFAQTNKKYAIKAIKP----NKYNSLKRILLEIKILNEVTNQ 499
Query: 124 SSHLITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYM---FILQQFCRGGNLEDTI 180
I +G +D ++ + +I+ + C GNL+ +
Sbjct: 500 --------------------ITMDQEGKEYIIDYISSWKFQNSYYIMTELCENGNLDGFL 539
Query: 181 QYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLH-SLRIIHRD 239
Q QV + ++K+L + + I I +++ L+ +H S I+H D
Sbjct: 540 QEQV----------IAKKKRLEDWR----------IWKIIVELSLALRFIHDSCHIVHLD 579
Query: 240 LKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQF 299
LKP+N ++ E + +GDFG + + + G E++APE+ +
Sbjct: 580 LKPANVMITFEGNLK---------LGDFGMATHLPLEDKSFENEGDREYIAPEIISDCTY 630
Query: 300 SFKSDIYAFGMIL 312
+K+DI++ G+++
Sbjct: 631 DYKADIFSLGLMI 643
>YGL180w [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 897
Score = 60.8 bits (146), Expect = 4e-09
Identities = 65/286 (22%), Positives = 112/286 (38%), Gaps = 58/286 (20%)
Query: 122 EESSHLITYNHVWLERCPVESLILTQNDGSSVN--MDIPTTMPYMFILQQFCRGGNLEDT 179
+E S N LE +E IL + + +D T +++ ++C G+L
Sbjct: 54 KEVSRAKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCERTSTDFYLIMEYCALGDLTFL 113
Query: 180 IQYQVFNRISGNESRLERRKKLL-NHKKSRI-------------GLTTRQIVSIANDIAT 225
L+RRK+L+ NH R GL ++S +A+
Sbjct: 114 ---------------LKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLAS 158
Query: 226 GLKQLHSLRIIHRDLKPSNCLL------------LEEFDRSDTDKFPKCVIGDFGESQLY 273
LK L S ++HRD+KP N LL E P I DFG ++
Sbjct: 159 ALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFARFL 218
Query: 274 GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKD----MSA 329
A G+ ++APE+ +++ K+D+++ G +++ + G PF + +
Sbjct: 219 PNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCGTPPFRASNHLELFKK 278
Query: 330 IKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLR 375
IK + ++F I+P L L+C +L P+ R
Sbjct: 279 IKRANDVITFP-----------SYCNIEPELKELICSLLTFDPAQR 313
>YDR490c [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 766
Score = 60.8 bits (146), Expect = 4e-09
Identities = 39/119 (32%), Positives = 57/119 (47%), Gaps = 23/119 (19%)
Query: 220 ANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDA 279
A+ I + LH++ IIHRD+KP N LL DK K + DFG +++ +
Sbjct: 230 ASQIIDAVDSLHNIGIIHRDIKPENILL---------DKNMKVKLTDFGTAKILPEEPSN 280
Query: 280 TGS--------------TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNS 324
T GT E+V+PEL + DI+AFG ILY ++ G+ PF +
Sbjct: 281 TADGKPYFDLYAKSKSFVGTAEYVSPELLNDNYTDSRCDIWAFGCILYQMLAGKPPFKA 339
>Hs8923539 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 542
Score = 60.8 bits (146), Expect = 4e-09
Identities = 64/284 (22%), Positives = 109/284 (37%), Gaps = 81/284 (28%)
Query: 70 LGNGSRAVVYKVKHMLLENELGTFALKKICIGDDMHWLYRCLKEVKLLNRLTEESSH--L 127
+G GS+ VVYK + N + K + +W+ RLT E H +
Sbjct: 10 IGRGSKTVVYKGRRKGTINFVAILCTDKCKRPEITNWV-----------RLTREIKHKNI 58
Query: 128 ITYNHVWLERCPVESLILTQNDGSSVNMDIPTTMPYMFILQQFCRGGNLEDTIQYQVFNR 187
+T+ H W E T +++++ + C GG+L+ I
Sbjct: 59 VTF-HEWYE-----------------------TSNHLWLVVELCTGGSLKTVIAQDE--- 91
Query: 188 ISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLL 247
L + D+ +GL LH L I+ D+ P LL
Sbjct: 92 ----------------------NLPEDVVREFGIDLISGLHHLHKLGILFCDISPRKILL 129
Query: 248 ------------LEEFDRSDTDKFPKCVI-----GDFGESQLYGQLRDATGSTGTVEFVA 290
L + + + ++F V GD GE+ L ++ G+ + A
Sbjct: 130 EGPGTLKFSNFCLAKVEGENLEEFFALVAAEEGGGDNGENVLKKSMKSRV--KGSPVYTA 187
Query: 291 PELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
PE+ +GA FS SD+++ G +LY + G+ PF S+ +S + +I
Sbjct: 188 PEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKI 231
>Hs20127541 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 427
Score = 60.8 bits (146), Expect = 4e-09
Identities = 40/116 (34%), Positives = 61/116 (52%), Gaps = 10/116 (8%)
Query: 220 ANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDA 279
A ++A+ + LHSL II+RDLKP N LL D V+ DFG + + D
Sbjct: 200 AAEVASAIGYLHSLNIIYRDLKPENILL---------DCQGHVVLTDFGLCKEGVEPEDT 250
Query: 280 TGS-TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
T + GT E++APE+ + + D + G +LY ++ G PF S+D+S + I
Sbjct: 251 TSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENI 306
>Hs14993776 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 596
Score = 60.8 bits (146), Expect = 4e-09
Identities = 36/116 (31%), Positives = 58/116 (49%), Gaps = 7/116 (6%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
LT + I G+ +H +R++H DLKP N L + + T K + DFG +
Sbjct: 378 LTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCV-----NTTGHLVKII--DFGLA 430
Query: 271 QLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKD 326
+ Y + GT EF++PE+ Q S K+D+++ G+I Y ++ G PF D
Sbjct: 431 RRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDD 486
>CE28494 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 1175
Score = 60.8 bits (146), Expect = 4e-09
Identities = 54/184 (29%), Positives = 85/184 (45%), Gaps = 16/184 (8%)
Query: 203 NHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCL--LLEEFDRSDTDKFP 260
+H+K+ L+ I A +A L+ LHS II+RDLK N L TD
Sbjct: 593 SHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLL 652
Query: 261 KCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTK---GAQFSFKSDIYAFGMILYFVIM 317
K +GD+G S+ A G GT F+APE+ + +++ K D ++FGM LY ++
Sbjct: 653 K--LGDYGISRSVLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLT 710
Query: 318 GQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPD 377
+ PF S++ H + + H+ L P + +L+ + P RP
Sbjct: 711 LKFPFESEE-----HVKERMLDGARPVLLPHELLLPTP----MLDLLVHCWSAHPESRPS 761
Query: 378 SSQI 381
SSQ+
Sbjct: 762 SSQL 765
>CE21025 [D] KOG0580 Serine/threonine protein kinase
Length = 326
Score = 60.8 bits (146), Expect = 4e-09
Identities = 40/141 (28%), Positives = 68/141 (47%), Gaps = 12/141 (8%)
Query: 198 RKKLLNHKKSRIGLTTRQIVS--IANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSD 255
R +L N +S+ G ++++ +A L HS +IHRD+KP N LL
Sbjct: 126 RGELFNVLQSQPGHKVNEVIAGRFVRQLANALHYCHSKGVIHRDIKPENLLL-------- 177
Query: 256 TDKFPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFV 315
D + DFG S + + T GT++++APE+ F DI+A G++L+ +
Sbjct: 178 -DSKLNLKLADFGWSVVADHSKRHT-LCGTMDYLAPEMVSNQPHDFNVDIWAIGILLFEM 235
Query: 316 IMGQLPFNSKDMSAIKHEINE 336
++G PF ++ + I E
Sbjct: 236 LVGYAPFANQTGDKLIARIKE 256
>CE00747 [T] KOG0200 Fibroblast/platelet-derived growth factor receptor and
related receptor tyrosine kinases
Length = 276
Score = 60.8 bits (146), Expect = 4e-09
Identities = 55/185 (29%), Positives = 89/185 (47%), Gaps = 17/185 (9%)
Query: 199 KKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDK 258
+ + K S + +++ +S N IA G+ L S+ IIHRDL N L+ T K
Sbjct: 89 QNMRKEKDSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILV-------GTGK 141
Query: 259 FPKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILY-FVIM 317
K I DFG S+ ++ + G + +++PE K +S KSD++AFG++L+ +
Sbjct: 142 VLK--ISDFGMSRPGVYIKMSKGVI-PLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATL 198
Query: 318 GQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPD 377
G P+N+ A K +N+L+ S D+ + S +NL E PS
Sbjct: 199 GGFPYNN---VADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAE---DRPSFLAI 252
Query: 378 SSQIE 382
S+IE
Sbjct: 253 LSKIE 257
>At5g66210 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 523
Score = 60.8 bits (146), Expect = 4e-09
Identities = 52/190 (27%), Positives = 86/190 (44%), Gaps = 32/190 (16%)
Query: 163 YMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIAND 222
Y++I+ + C GG L D I + NR S ++ + RQ++ +A +
Sbjct: 135 YVYIVMELCEGGELLDRILSKKGNRYSEKDA----------------AVVVRQMLKVAGE 178
Query: 223 IATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGS 282
LH L +HRD+KP N L F + D K DFG S +
Sbjct: 179 C-----HLHGL--VHRDMKPENFL----FKSAQLDSPLKAT--DFGLSDFIKPGKRFHDI 225
Query: 283 TGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI--NELSFS 340
G+ +VAPE+ K + +SD+++ G+I Y ++ G+ PF + I E+ N+ FS
Sbjct: 226 VGSAYYVAPEVLK-RRSGPESDVWSIGVITYILLCGRRPFWDRTEDGIFKEVLRNKPDFS 284
Query: 341 PEAMSKLHDS 350
+ + + DS
Sbjct: 285 RKPWATISDS 294
>At5g47070 [T] KOG1187 Serine/threonine protein kinase
Length = 410
Score = 60.8 bits (146), Expect = 4e-09
Identities = 46/147 (31%), Positives = 66/147 (44%), Gaps = 21/147 (14%)
Query: 176 LEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRI 235
+E + Y+ + S + RR L KK + I A GL LH L++
Sbjct: 164 IERLLVYEYMSNRSLEDHLFPRRSHTLPWKKR---------LEIMLGAAEGLTYLHDLKV 214
Query: 236 IHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG---ESQLYGQLRDATGSTGTVEFVAPE 292
I+RD K SN LL ++F PK + DFG E T GT + APE
Sbjct: 215 IYRDFKSSNVLLDDQF-------CPK--LSDFGLAREGPDGDNTHVTTARVGTHGYAAPE 265
Query: 293 LTKGAQFSFKSDIYAFGMILYFVIMGQ 319
+ KSD+Y+FG++LY +I G+
Sbjct: 266 YVQTGHLRLKSDVYSFGVVLYEIITGR 292
>At5g01820 [T] KOG0583 Serine/threonine protein kinase
Length = 442
Score = 60.8 bits (146), Expect = 4e-09
Identities = 51/135 (37%), Positives = 65/135 (47%), Gaps = 19/135 (14%)
Query: 231 HSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLR-DATGST--GTVE 287
HS I HRDLKP N LL E+ D I DFG S L Q+R D T GT
Sbjct: 136 HSRGIFHRDLKPENLLLDEKLDLK---------ISDFGLSALTDQIRPDGLLHTLCGTPA 186
Query: 288 FVAPE-LTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSF------S 340
+VAPE L K K DI++ G+IL+ + G LPFN ++ + +I + F S
Sbjct: 187 YVAPEVLAKKGYDGAKIDIWSCGIILFVLNAGYLPFNDHNLMVMYRKIYKGEFRIPKWTS 246
Query: 341 PEAMSKLHDSLDLAP 355
P+ L LD P
Sbjct: 247 PDLRRLLTRLLDTNP 261
>At4g04700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 347
Score = 60.8 bits (146), Expect = 4e-09
Identities = 57/220 (25%), Positives = 95/220 (42%), Gaps = 43/220 (19%)
Query: 166 ILQQFCRGGNLEDTIQ--YQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDI 223
I+ ++C GG L D I Y V S E+ I I
Sbjct: 104 IVMEYCGGGELYDKILALYDVGKSYSEKEA-----------------------AGIIRSI 140
Query: 224 ATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGST 283
+K H + ++HRDLKP N LL D + + DFG S + +
Sbjct: 141 VNVVKNCHYMGVMHRDLKPENFLLTSNDDNATVK------VIDFGCSVFIEEGKVYQDLA 194
Query: 284 GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEIN--ELSFSP 341
G+ ++APE+ +G + ++DI++ G+ILY ++ G+ PF + + +EI E+ +S
Sbjct: 195 GSDYYIAPEVLQG-NYGKEADIWSAGIILYILLCGKSPFVKEPEGQMFNEIKSLEIDYSE 253
Query: 342 EAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQI 381
E L DS + +LV ML+ P R ++++
Sbjct: 254 EPW-PLRDSRAI--------HLVKRMLDRNPKERISAAEV 284
>At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 277
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/135 (31%), Positives = 65/135 (48%), Gaps = 13/135 (9%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCV-IGDFGE 269
L+ + S A I + L H ++HRD+KP N L+ D V + DFG
Sbjct: 109 LSESESASYAKQILSALAHCHRCDVVHRDVKPDNVLV---------DLVSGGVKLCDFGS 159
Query: 270 SQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSA 329
+ G A G GT +VAPE+ G ++ K DI++ G+++Y ++ G+ PFN +
Sbjct: 160 AVWLGG-ETAEGVVGTPYYVAPEVVMGRKYDEKVDIWSAGVVIYTMLAGEPPFNGETAED 218
Query: 330 IKHEI--NELSFSPE 342
I I L F P+
Sbjct: 219 IFESILRGNLRFPPK 233
>At1g70460 [T] KOG1187 Serine/threonine protein kinase
Length = 710
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/123 (34%), Positives = 65/123 (52%), Gaps = 14/123 (11%)
Query: 204 HKKSRIGLTTRQIVSIANDIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSDTDKFP 260
H K R L + V IA A GL LH +IIHRD+K +N LL +EF+
Sbjct: 439 HGKGRPVLEWARRVRIAIGSAKGLAYLHEDCHPKIIHRDIKSANILLDDEFEAQ------ 492
Query: 261 KCVIGDFGESQLYG--QLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMG 318
+ DFG ++L Q +T GT ++APE + + + +SD+++FG++L +I G
Sbjct: 493 ---VADFGLAKLNDSTQTHVSTRVMGTFGYLAPEYAQSGKLTDRSDVFSFGVVLLELITG 549
Query: 319 QLP 321
+ P
Sbjct: 550 RKP 552
>At1g25390 [T] KOG1187 Serine/threonine protein kinase
Length = 629
Score = 60.8 bits (146), Expect = 4e-09
Identities = 56/192 (29%), Positives = 87/192 (45%), Gaps = 32/192 (16%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
LT +SIA + A+ L LH+ IIHRD+K +N LL F + DFG S
Sbjct: 388 LTWSMRLSIAIETASALAYLHASDIIHRDVKTTNILLDRNFG---------VKVADFGLS 438
Query: 271 QLYGQ--LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMS 328
+L +T GT +V PE + + KSD+Y+FG++L +I + + D+S
Sbjct: 439 RLLPSDVTHVSTAPQGTPGYVDPEYHRCYHLTDKSDVYSFGVVLVELISSK---PAVDIS 495
Query: 329 AIKHEINELSFSPEAMSKLHDSLDLAPIDPSL---------------YNLVCEMLNHTPS 373
K EIN S A++K+ + ID +L L + L +
Sbjct: 496 RCKSEIN---LSSLAINKIQNHATHELIDQNLGYATNEGVRKMTTMVAELAFQCLQQDNT 552
Query: 374 LRPDSSQIEYQL 385
+RP Q+ ++L
Sbjct: 553 MRPTMEQVVHEL 564
>At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 990
Score = 60.8 bits (146), Expect = 4e-09
Identities = 50/175 (28%), Positives = 84/175 (47%), Gaps = 23/175 (13%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLR--IIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFG 268
L R+ + +A D A G+ LHS I+HRDLK N L+ DK + DFG
Sbjct: 806 LDERKRLRMALDAARGMNYLHSCNPVIVHRDLKSPNLLV---------DKNWVVKVCDFG 856
Query: 269 ESQLYGQLRDATGST-GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDM 327
S++ ++ ST GT E++APE+ + K D+Y++G+IL+ + Q P+ +
Sbjct: 857 LSRMKVSTYLSSKSTAGTAEWMAPEVLRNEPADEKCDVYSYGVILWELFTLQQPWGKMNP 916
Query: 328 SAIKHEINELSFSPEAMSKLHDSLDLAP-IDPSLYNLVCEMLNHTPSLRPDSSQI 381
+ + + F H LD+ +DP + +++ + P LRP +I
Sbjct: 917 MQV---VGAVGFQ-------HRRLDIPEFVDPGIADIIRKCWQTDPRLRPSFGEI 961
>At1g10620 [T] KOG1187 Serine/threonine protein kinase
Length = 718
Score = 60.8 bits (146), Expect = 4e-09
Identities = 51/168 (30%), Positives = 81/168 (47%), Gaps = 24/168 (14%)
Query: 204 HKKSRIGLTTRQIVSIANDIATGLKQLHS---LRIIHRDLKPSNCLLLEEFDRSDTDKFP 260
H K+ L + V IA A GL LH +IIHRD+K SN LL +EF+
Sbjct: 456 HGKNLPVLEWSRRVRIAIGAAKGLAYLHEDCHPKIIHRDIKSSNILLDDEFEAQ------ 509
Query: 261 KCVIGDFGESQLY--GQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMG 318
+ DFG ++L Q +T GT ++APE + + +SD+++FG++L +I G
Sbjct: 510 ---VADFGLARLNDTAQSHISTRVMGTFGYLAPEYASSGKLTDRSDVFSFGVVLLELITG 566
Query: 319 QLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPI----DPSLYN 362
+ P ++ + E S A +L ++++ I DP L N
Sbjct: 567 RKPVDT------SQPLGEESLVEWARPRLIEAIEKGDISEVVDPRLEN 608
>YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 398
Score = 60.5 bits (145), Expect = 5e-09
Identities = 43/125 (34%), Positives = 67/125 (53%), Gaps = 15/125 (12%)
Query: 220 ANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDA 279
A ++ L+ LHS II+RDLKP N LL DK I DFG ++ + D
Sbjct: 192 AAEVCLALEYLHSKDIIYRDLKPENILL---------DKNGHIKITDFGFAKY---VPDV 239
Query: 280 TGST-GTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPF-NSKDMSAIKHEIN-E 336
T + GT +++APE+ ++ D ++FG+++Y ++ G PF NS M ++ +N E
Sbjct: 240 TYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAE 299
Query: 337 LSFSP 341
L F P
Sbjct: 300 LKFPP 304
>YGL179c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 560
Score = 60.5 bits (145), Expect = 5e-09
Identities = 47/132 (35%), Positives = 65/132 (48%), Gaps = 32/132 (24%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
LT +Q + D+ +GL+ LHS I HRD+KPSN L+ + T K I DFG +
Sbjct: 161 LTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLI----SSNGTVK-----ISDFGVA 211
Query: 271 QLYGQLRDATGST---------------GTVEFVAPEL---TKGAQFSFKSDIYAFGMIL 312
+ ATGST GT F APEL K S DI++ G+ +
Sbjct: 212 -----MSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTI 266
Query: 313 YFVIMGQLPFNS 324
Y ++ G+LPFN+
Sbjct: 267 YCLLFGKLPFNA 278
>SPBC12D12.04c [T] KOG0694 Serine/threonine protein kinase
Length = 1016
Score = 60.5 bits (145), Expect = 5e-09
Identities = 51/181 (28%), Positives = 86/181 (47%), Gaps = 25/181 (13%)
Query: 178 DTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIH 237
+T Y V + +SG + L +++ + ++++ A ++ LK H II+
Sbjct: 756 ETRIYFVMDFVSGGDLMLHIQQEQFSRRRAQF---------YAAEVCLALKYFHDNGIIY 806
Query: 238 RDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDATGST--GTVEFVAPELTK 295
RDLK N LL D K + D+G + D T +T GT EF+APE+
Sbjct: 807 RDLKLDNILL-------SPDGHVK--VADYGLCK-EDMWHDNTTATFCGTPEFMAPEILL 856
Query: 296 GAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEINELSFSPEAMSKLHDSLDLAP 355
Q++ D +AFG+++Y +++GQ PF +D + EI + S E + +H D
Sbjct: 857 EQQYTRSVDWWAFGVLIYQMLLGQSPFRGED----EEEIFDAILSDEPLYPIHMPRDSVS 912
Query: 356 I 356
I
Sbjct: 913 I 913
>Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 370
Score = 60.5 bits (145), Expect = 5e-09
Identities = 46/179 (25%), Positives = 76/179 (41%), Gaps = 31/179 (17%)
Query: 156 DIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQ 215
DI + +++++ Q GG L D I + F T R
Sbjct: 83 DIYESGGHLYLIMQLVSGGELFDRIVEKGF-------------------------YTERD 117
Query: 216 IVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQ 275
+ + +K LH L I+HRDLKP N L D+ K +I DFG S++
Sbjct: 118 ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYS------LDEDSKIMISDFGLSKMEDP 171
Query: 276 LRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
+ + GT +VAPE+ +S D ++ G+I Y ++ G PF ++ + + +I
Sbjct: 172 GSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQI 230
>Hs21361133 [R] KOG0586 Serine/threonine protein kinase
Length = 752
Score = 60.5 bits (145), Expect = 5e-09
Identities = 42/180 (23%), Positives = 87/180 (48%), Gaps = 12/180 (6%)
Query: 156 DIPTTMPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQ 215
++ T ++++ ++ GG + D + ++ E+R + R+ + ++ ++
Sbjct: 120 EVIETEKTLYLIMEYASGGEVFDYLV--AHGKMKEKEARSKFRQGCQAGQTIKVQVSFDL 177
Query: 216 IVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQ 275
+ + I + ++ H RI+HRDLK N LL D D K I DFG S +
Sbjct: 178 LSLMFTFIVSAVQYCHQKRIVHRDLKAENLLL-------DADMNIK--IADFGFSNEFTV 228
Query: 276 LRDATGSTGTVEFVAPELTKGAQFSFKS-DIYAFGMILYFVIMGQLPFNSKDMSAIKHEI 334
G+ + APEL +G ++ D+++ G+ILY ++ G LPF+ +++ ++ +
Sbjct: 229 GGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV 288
>Hs21166359 [T] KOG0986 G protein-coupled receptor kinase
Length = 553
Score = 60.5 bits (145), Expect = 5e-09
Identities = 39/142 (27%), Positives = 66/142 (46%), Gaps = 11/142 (7%)
Query: 210 GLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGE 269
GL +++ + IA G+ LH L I++RD+KP N LL D C + D G
Sbjct: 287 GLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLL---------DDLGNCRLSDLGL 337
Query: 270 SQLYGQLRDATGSTGTVEFVAPE-LTKGAQFSFKSDIYAFGMILYFVIMGQLPFNSKDMS 328
+ + T GT ++APE L + +S+ D +A G +Y ++ G+ PF
Sbjct: 338 AVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEK 397
Query: 329 AIKHEINELSFSPEAMSKLHDS 350
K ++ + + E + HD+
Sbjct: 398 VSKEDLKQRTLQDEVKFQ-HDN 418
>Hs14670383 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 370
Score = 60.5 bits (145), Expect = 5e-09
Identities = 39/148 (26%), Positives = 69/148 (46%), Gaps = 12/148 (8%)
Query: 200 KLLNHKKSRIGLTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKF 259
+L + + L+ + S I G+ LH+ +I H DLKP N +LL++
Sbjct: 110 ELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDK-----NIPI 164
Query: 260 PKCVIGDFGESQLYGQLRDATGSTGTVEFVAPELTKGAQFSFKSDIYAFGMILYFVIMGQ 319
P + DFG + + GT EFVAPE+ ++D+++ G+I Y ++ G
Sbjct: 165 PHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGA 224
Query: 320 LPF-------NSKDMSAIKHEINELSFS 340
PF +++A+ ++ +E FS
Sbjct: 225 SPFLGDTKQETLANITAVSYDFDEEFFS 252
>CE17429 [T] KOG0194 Protein tyrosine kinase
Length = 445
Score = 60.5 bits (145), Expect = 5e-09
Identities = 54/229 (23%), Positives = 97/229 (41%), Gaps = 52/229 (22%)
Query: 161 MPYMFILQQFCRGGNLEDTIQYQVFNRISGNESRLERRKKLLNHKKSRIGLTTRQIVSIA 220
+PY+ +L+ FC GG++ED ++ + E ++ RR V
Sbjct: 247 VPYLLVLE-FCNGGSVEDLLRDKP-------EIKINRR------------------VQYT 280
Query: 221 NDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGESQLYGQLRDAT 280
A G+ LH IHRD+ NCL+ + + DFG + +
Sbjct: 281 YMAACGMDYLHKKNCIHRDIASRNCLIHNGVVK----------MADFGMCRATAVYKVDL 330
Query: 281 GSTGTVEFVAPELTKGAQFSFKSDIYAFGMIL--YFVIMGQLPFNSKDMSAIKHEI--NE 336
V ++APE+ + + +D+YAFG+++ +F+ Q P+ +K ++
Sbjct: 331 SKPLNVRWLAPEVWTNGETRYNTDVYAFGVMIWEFFITPYQSPYTEWKGYTVKQKVRGGY 390
Query: 337 LSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQIEYQL 385
PE M K D+A +L+ E NH P RP++ +++ +L
Sbjct: 391 RMQPPEGMPK-----DVA-------SLLAECWNHDPEKRPNAEKLKEKL 427
>At5g40540 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 353
Score = 60.5 bits (145), Expect = 5e-09
Identities = 54/201 (26%), Positives = 82/201 (39%), Gaps = 26/201 (12%)
Query: 211 LTTRQIVSIANDIATGLKQLHSLRIIHRDLKPSNCLLLEEFDRSDTDKFPKCVIGDFGES 270
L R V A DIA ++ LHS +IHRDLKP + +L T + + DFG +
Sbjct: 122 LDIRVAVGYALDIARAMECLHSHGVIHRDLKPESLIL--------TADYKTVKLADFGLA 173
Query: 271 QLYGQLRDATGSTGTVEFVAPEL--------TKGAQFSFKSDIYAFGMILYFVIMGQLPF 322
+ T TGT ++APEL + ++ K D Y+F ++L+ +I +LPF
Sbjct: 174 REESLTEMMTAETGTYRWMAPELYSTVTLRHGEKKHYNHKVDAYSFAIVLWELIHNKLPF 233
Query: 323 NSKDMSAIKHEINELSFSPEAMSKLHDSLDLAPIDPSLYNLVCEMLNHTPSLRPDSSQIE 382
N + A + S D P D L +V P+ RP+ ++I
Sbjct: 234 EGMS--------NLQAAYAAAFKNVRPSADDLPKD--LAMIVTSCWKEDPNDRPNFTEII 283
Query: 383 YQLXXXXXXXXXXXXQEPEIR 403
L P I+
Sbjct: 284 QMLLRCLSTISSTELVPPAIK 304
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.323 0.139 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,216,692
Number of Sequences: 60738
Number of extensions: 1152211
Number of successful extensions: 6436
Number of sequences better than 1.0e-05: 915
Number of HSP's better than 0.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 902
Number of HSP's that attempted gapping in prelim test: 5265
Number of HSP's gapped (non-prelim): 1021
length of query: 472
length of database: 30,389,216
effective HSP length: 110
effective length of query: 362
effective length of database: 23,708,036
effective search space: 8582309032
effective search space used: 8582309032
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)