ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0493 check: MH E KOG1481 Amino acid transport and metabolism Cysteine synthase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0493 166880 167944 355
(355 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
SPBC36.04 [E] KOG1481 Cysteine synthase 388 e-108
YGR012w [E] KOG1481 Cysteine synthase 237 2e-62
SPAC3A12.17c [E] KOG1481 Cysteine synthase 207 2e-53
At1g55880 [E] KOG1481 Cysteine synthase 180 2e-45
Hs4557415 [E] KOG1252 Cystathionine beta-synthase and related en... 163 3e-40
YGR155w [E] KOG1252 Cystathionine beta-synthase and related enzymes 162 9e-40
7295550 [E] KOG1252 Cystathionine beta-synthase and related enzymes 155 9e-38
CE12574 [E] KOG1252 Cystathionine beta-synthase and related enzymes 141 2e-33
At4g14880 [E] KOG1252 Cystathionine beta-synthase and related en... 140 3e-33
At3g22460 [E] KOG1252 Cystathionine beta-synthase and related en... 139 8e-33
At5g28030 [E] KOG1252 Cystathionine beta-synthase and related en... 137 3e-32
At3g59760 [E] KOG1252 Cystathionine beta-synthase and related en... 135 7e-32
At2g43750 [E] KOG1252 Cystathionine beta-synthase and related en... 135 1e-31
CE16252 [E] KOG1252 Cystathionine beta-synthase and related enzymes 134 2e-31
CE08286 [E] KOG1252 Cystathionine beta-synthase and related enzymes 133 3e-31
At3g04940 [E] KOG1252 Cystathionine beta-synthase and related en... 133 5e-31
CE11452 [E] KOG1252 Cystathionine beta-synthase and related enzymes 132 1e-30
At5g28020 [E] KOG1252 Cystathionine beta-synthase and related en... 128 1e-29
CE20851 [E] KOG1252 Cystathionine beta-synthase and related enzymes 126 6e-29
CE25661 [E] KOG1252 Cystathionine beta-synthase and related enzymes 122 1e-27
At3g03630 [E] KOG1252 Cystathionine beta-synthase and related en... 119 5e-27
At3g61440 [E] KOG1252 Cystathionine beta-synthase and related en... 111 1e-24
CE19600 [E] KOG1252 Cystathionine beta-synthase and related enzymes 65 2e-10
CE05602 [E] KOG1252 Cystathionine beta-synthase and related enzymes 64 3e-10
CE09160 [E] KOG1252 Cystathionine beta-synthase and related enzymes 57 4e-08
SPBC1677.03c [E] KOG1250 Threonine/serine dehydratases 52 1e-06
CE26153 [E] KOG1250 Threonine/serine dehydratases 52 2e-06
Hs19923959 [E] KOG1250 Threonine/serine dehydratases 50 5e-06
>SPBC36.04 [E] KOG1481 Cysteine synthase
Length = 351
Score = 388 bits (996), Expect = e-108
Identities = 199/340 (58%), Positives = 249/340 (72%), Gaps = 7/340 (2%)
Query: 17 GFTDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSR 76
GF AIG TPLI++ LS E G NI K+E QNPGGSVKDRAA Y++ DAEKKG + SR
Sbjct: 16 GFIGAIGRTPLIRLNTLSNETGCNILAKAEFQNPGGSVKDRAAYYVVRDAEKKGKL--SR 73
Query: 77 PVTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITD 136
T+VEG+AGNT IGLAHI +A+GY V YMP+TQS+AKI+ LK+LGAEV+PVPV P ++
Sbjct: 74 GGTIVEGTAGNTGIGLAHIARARGYKCVIYMPNTQSQAKIDTLKFLGAEVHPVPVAPFSN 133
Query: 137 PLNFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXX 196
PLN+N++AR HA+ NA WTDQFDN +N +HY TT PEI Q + +D FTCS
Sbjct: 134 PLNYNHQARRHAESTPNASWTDQFDNVANLLSHYETTGPEIWDQTKGT---VDGFTCSTG 190
Query: 197 XXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTR--ELKREGGSFTEGIGQGRIT 254
V K+LKE ++G VADPPGSV+YS+IKT+ +G SFTEGIGQGRIT
Sbjct: 191 TGGTFAGVTKYLKEKSDGRVASFVADPPGSVLYSHIKTKGKHPDNKGSSFTEGIGQGRIT 250
Query: 255 ENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPEGSNV 314
N++ D+ DDA+ IPDE+SI M FRLLD+EGLF+GG++ LNVVAA ++A+ L G V
Sbjct: 251 GNVQPVYDLIDDAMKIPDEKSINMFFRLLDQEGLFLGGSSCLNVVAAVEMAKILGPGKTV 310
Query: 315 ATILCDSGHKYADRVFSKSWLQSKKLYDVLPDHLKKYASL 354
TILCDSGHKYA R+FS+S+L+SKKL+DV+ KKY L
Sbjct: 311 VTILCDSGHKYATRLFSRSFLESKKLFDVIEPQYKKYIVL 350
>YGR012w [E] KOG1481 Cysteine synthase
Length = 393
Score = 237 bits (605), Expect = 2e-62
Identities = 140/346 (40%), Positives = 192/346 (55%), Gaps = 24/346 (6%)
Query: 12 PLANKGFTDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGL 71
P +G + IG+TPL+KI+ L+K G NIY K EL NP GS KDR AL +I+ AE+ G
Sbjct: 43 PRPKEGVEELIGNTPLVKIRSLTKATGVNIYAKLELCNPAGSAKDRVALNIIKTAEELGE 102
Query: 72 IDPSRPVTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPV 131
+ P V EG++G+T I +A +C A GY A +PD S K+ LL+ LGA V V
Sbjct: 103 LVRGEPGWVFEGTSGSTGISIAVVCNALGYRAHISLPDDTSLEKLALLESLGATVNKVKP 162
Query: 132 CPITDPLNFNNRARDHAKRLD------NAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAG 185
I DP + N A+ L AV+ DQF+N++NWK HY TT PEI Q +
Sbjct: 163 ASIVDPNQYVNAAKKACNELKKSGNGIRAVFADQFENEANWKVHYQTTGPEIAHQTKG-- 220
Query: 186 MMLDAFTCSXXXXXXXXXVAKFLKEATNGNCKLVVADPPGS---------VIYSYIKTRE 236
+DAF VAKFLKE C +V+ADP GS V+Y Y++
Sbjct: 221 -NIDAFIAGCGTGGTITGVAKFLKERAKIPCHVVLADPQGSGFYNRVNYGVMYDYVEKEG 279
Query: 237 LKR--EGGSFTEGIGQGRITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTT 294
+R + + EGIG RIT N D+++ + D ++I M L +GLFVG +T
Sbjct: 280 TRRRHQVDTIVEGIGLNRITHNFHMGEKFIDESIRVNDNQAIRMAKYLSVNDGLFVGSST 339
Query: 295 ALNVVAAAKVAQTLPEGSNVATILCDSGHKYADRVFSKSWLQSKKL 340
A+N VAA +VA+TLP GSN+ I CDSG ++ SK W ++K++
Sbjct: 340 AINAVAAIQVAKTLPHGSNIVIIACDSGSRH----LSKFWKEAKEI 381
>SPAC3A12.17c [E] KOG1481 Cysteine synthase
Length = 395
Score = 207 bits (527), Expect = 2e-53
Identities = 122/350 (34%), Positives = 202/350 (56%), Gaps = 22/350 (6%)
Query: 17 GFTDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSR 76
G IG+T +++I+ LS+ G +I K+E NPG S KDR AL +I AE+ G + P +
Sbjct: 45 GVEGLIGNTKMVRIKSLSQATGCDILAKAEFLNPGNSPKDRVALQMIRTAEENGDLVPYQ 104
Query: 77 PVTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITD 136
V EG+AG+T I +A +C + GY++ YMP QS+ K ++L+ LGA V V PI D
Sbjct: 105 SNAVYEGTAGSTGISIAMLCCSLGYDSRIYMPSDQSKEKSDILELLGAHVQRVTPAPIVD 164
Query: 137 PLNFNNRARDHAKR--LDNAV-----WTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLD 189
P +F N AR +A +D ++ + +QF+N +NW+AH+++T PEI +Q AG LD
Sbjct: 165 PNHFVNTARRNAANHTVDESIPGKGYFANQFENPANWQAHFNSTGPEIWRQC--AG-KLD 221
Query: 190 AFTCSXXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTREL----KREG---- 241
AF ++++LK + + + + +ADPPGS +Y + + +REG
Sbjct: 222 AFIAGSGTGGTIAGISRYLK-SKDPSITVCLADPPGSGLYHKVLHGVMFDLAEREGTRRR 280
Query: 242 ---GSFTEGIGQGRITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNV 298
+ EG+G R+T N + + D A + DE+++ M L+ +GLFVG ++A+N
Sbjct: 281 HQVDTIVEGVGINRMTRNFSIAEPLIDMAYRVTDEQAVAMSRYLVTHDGLFVGSSSAVNC 340
Query: 299 VAAAKVAQTLPEGSNVATILCDSGHKYADRVFSKSWLQSKKLYDVLPDHL 348
VAA ++A+ L G + T+LCD G ++ +++++ +L+ K + +P L
Sbjct: 341 VAAVRLAKKLGPGHRIVTLLCDPGSRHFSKLYNEEFLRKKNIVPQVPSSL 390
>At1g55880 [E] KOG1481 Cysteine synthase
Length = 421
Score = 180 bits (457), Expect = 2e-45
Identities = 131/379 (34%), Positives = 186/379 (48%), Gaps = 61/379 (16%)
Query: 17 GFTDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSR 76
G DAIG+TPLI+I LS+ G I GK E NPGGSVKDR A+ +I++A + G + P
Sbjct: 43 GLVDAIGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIQEALESGKLFPGG 102
Query: 77 PVTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITD 136
VT EGSAG+TAI LA + A G +PD + K +++ LGA V V IT
Sbjct: 103 IVT--EGSAGSTAISLATVAPAYGCKCHVVIPDDAAIEKSQIIEALGASVERVRPVSITH 160
Query: 137 PLNFNNRARDHA---------KRLDNAV------------------------------WT 157
++ N AR A +RL + +
Sbjct: 161 KDHYVNIARRRADEANELASKRRLGSETNGIHQEKTNGCTVEEVKEPSLFSDSVTGGFFA 220
Query: 158 DQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXXXXXXXXXVAKFLKEATNGNCK 217
DQF+N +N++AHY T PEI Q + +DAF + V++FL++ N K
Sbjct: 221 DQFENLANYRAHYEGTGPEIWHQTQGN---IDAFVAAAGTGGTLAGVSRFLQDK-NERVK 276
Query: 218 LVVADPPGSVIYSYI-----------KTRELKREGGSFTEGIGQGRITENMRQSVDITDD 266
+ DPPGS +Y+ + + R LK + TEGIG R+T+N + D
Sbjct: 277 CFLIDPPGSGLYNKVTRGVMYTREEAEGRRLKNPFDTITEGIGINRLTKNFLMAK--LDG 334
Query: 267 AVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPEGSNVATILCDSGHKYA 326
D+E++ M LL +GLFVG ++A+N V A +VAQTL G + TILCDSG ++
Sbjct: 335 GFRGTDKEAVEMSRFLLKNDGLFVGSSSAMNCVGAVRVAQTLGPGHTIVTILCDSGMRHL 394
Query: 327 DRVFSKSWLQSKKLYDVLP 345
+ +L LY + P
Sbjct: 395 SKFHDPKYL---NLYGLSP 410
>Hs4557415 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 551
Score = 163 bits (413), Expect = 3e-40
Identities = 110/320 (34%), Positives = 158/320 (49%), Gaps = 12/320 (3%)
Query: 22 IGSTPLIKIQRLSKELGRN--IYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVT 79
IG TP+++I ++ K+ G + K E N GGSVKDR +L +IEDAE+ G + P T
Sbjct: 84 IGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGD--T 141
Query: 80 VVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPV-CPITDPL 138
++E ++GNT IGLA +GY + MP+ S K+++L+ LGAE+ P P
Sbjct: 142 IIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPE 201
Query: 139 NFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXXXX 198
+ A + N+ DQ+ N SN AHY TTA EILQQ + LD S
Sbjct: 202 SHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDG---KLDMLVASVGTG 258
Query: 199 XXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRITENMR 258
+A+ LKE G C+++ DP GS++ + + ++ EGIG I +
Sbjct: 259 GTITGIARKLKEKCPG-CRIIGVDPEGSILAEPEELNQTEQTTYE-VEGIGYDFIPTVLD 316
Query: 259 QSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPEGSNVATIL 318
++V D DEE+ L+ +EGL GG+ V A K AQ L EG IL
Sbjct: 317 RTV--VDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVIL 374
Query: 319 CDSGHKYADRVFSKSWLQSK 338
DS Y + S W+ K
Sbjct: 375 PDSVRNYMTKFLSDRWMLQK 394
>YGR155w [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 507
Score = 162 bits (409), Expect = 9e-40
Identities = 115/337 (34%), Positives = 172/337 (50%), Gaps = 25/337 (7%)
Query: 20 DAIGSTPLIKIQRLSKELG--RNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRP 77
D +G+TPLI +++L K LG IY K EL NPGGS+KDR A ++E+AE G I PSR
Sbjct: 16 DLVGNTPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIAKSMVEEAEASGRIHPSRS 75
Query: 78 VTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITD- 136
T++E ++GNT IGLA I KGY + +P+ S K+++LK LGAE+ P D
Sbjct: 76 -TLIEPTSGNTGIGLALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDS 134
Query: 137 PLNFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMM--LDAFTCS 194
P + A+ K + AV DQ++N N +AHY T EI +Q+E+ + L A
Sbjct: 135 PESHIGVAKKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAG 194
Query: 195 XXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREG--GSFTEGIGQGR 252
++K+LKE N ++V ADP GS++ + L + EGIG
Sbjct: 195 AGTGGTISGISKYLKE-QNDKIQIVGADPFGSIL---AQPENLNKTDITDYKVEGIGYDF 250
Query: 253 ITENM-RQSVDI---TDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTL 308
+ + + R+ +D+ TD D+ S +L+ EG+ VGG++ A K +
Sbjct: 251 VPQVLDRKLIDVWYKTD------DKPSFKYARQLISNEGVLVGGSSGSAFTAVVKYCEDH 304
Query: 309 PEGSN---VATILCDSGHKYADRVFSKSWLQSKKLYD 342
PE + + I DS Y + WL+ L+D
Sbjct: 305 PELTEDDVIVAIFPDSIRSYLTKFVDDEWLKKNNLWD 341
>7295550 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 522
Score = 155 bits (392), Expect = 9e-38
Identities = 104/331 (31%), Positives = 162/331 (48%), Gaps = 12/331 (3%)
Query: 20 DAIGSTPLIKIQRL--SKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRP 77
+ IG TPL+K+ + S + +Y K E NPGGSVKDR +++DAE++GL+ P
Sbjct: 51 EVIGCTPLVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPG-- 108
Query: 78 VTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITD- 136
T++E ++GNT IGLA C KGY + MP+ S K++ L+ LGA++ P D
Sbjct: 109 YTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDS 168
Query: 137 PLNFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXX 196
P A+ + N++ DQ+ N N AHY TA EIL Q++ +D S
Sbjct: 169 PEGLIYVAQQLQRETPNSIVLDQYRNAGNPLAHYDGTAAEILWQLDN---KVDMIVVSAG 225
Query: 197 XXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRITEN 256
+ + +KE +C++V DP GS++ + EL + F E G G
Sbjct: 226 TAGTISGIGRKIKEQV-PSCQIVGVDPYGSIL---ARPAELNKTDVQFYEVEGIGYDFPP 281
Query: 257 MRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPEGSNVAT 316
+ D I D + M RL EEGL GG++ + AA + A+ L +G
Sbjct: 282 TVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGLLCGGSSGGAMHAALEHARKLKKGQRCVV 341
Query: 317 ILCDSGHKYADRVFSKSWLQSKKLYDVLPDH 347
IL D Y + S +W++++ + + +H
Sbjct: 342 ILPDGIRNYMTKFVSDNWMEARNFKEPVNEH 372
>CE12574 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 337
Score = 141 bits (355), Expect = 2e-33
Identities = 105/316 (33%), Positives = 163/316 (51%), Gaps = 26/316 (8%)
Query: 20 DAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVT 79
D IG+TPL+ ++ +SK L I K E NP SVKDR A ++++AEK G I P + V
Sbjct: 12 DTIGNTPLVLLRNISKGLDARIAVKVEYLNPSCSVKDRIAKSMVDEAEKAGTIVPGKTV- 70
Query: 80 VVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPLN 139
+VEG++GN I LAHI K +GY + MP T S + +L+ GAEV ++DP
Sbjct: 71 LVEGTSGNLGIALAHIGKIRGYKVILVMPATMSVERRAMLRAYGAEVI------LSDPAE 124
Query: 140 FN----NRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSX 195
+ + +L NA DQF N +N AHY TT PEI +Q E +D
Sbjct: 125 GHPGVIKKVEMLVDKLPNAHCLDQFSNPANPAAHYRTTGPEIWRQTEG---KVDIVCFGV 181
Query: 196 XXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRITE 255
V ++L+E N N ++ +P S + S + G +GIG G +
Sbjct: 182 GSSGTVTGVGRYLRE-QNPNIEIYPVEPYESSVLSGLP------RGPHKIQGIGAGIVPG 234
Query: 256 NMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPEGSNVA 315
N+ +S + + + I ++++ M RL DEE + G ++ NVVAA ++A + PE N
Sbjct: 235 NVDRS--LFTEILRIKSDDAMQMARRLADEEAILGGISSGANVVAAVELA-SRPE--NKG 289
Query: 316 TILCDSGHKYADRVFS 331
++ + + +A+R F+
Sbjct: 290 KLIVTTVNSFAERYFT 305
>At4g14880 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 322
Score = 140 bits (353), Expect = 3e-33
Identities = 108/320 (33%), Positives = 151/320 (46%), Gaps = 26/320 (8%)
Query: 16 KGFTDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPS 75
K T+ IG+TPL+ + +++ + K E+ P SVKDR +I DAEKKGLI P
Sbjct: 7 KDVTELIGNTPLVYLNNVAEGCVGRVAAKLEMMEPCSSVKDRIGFSMISDAEKKGLIKPG 66
Query: 76 RPVTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPIT 135
V ++E ++GNT +GLA AKGY + MP + S + +L G E+ +T
Sbjct: 67 ESV-LIEPTSGNTGVGLAFTAAAKGYKLIITMPASMSTERRIILLAFGVELV------LT 119
Query: 136 DPLNFNN----RARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAF 191
DP +A + + N QF+N +N K HY TT PEI + G +D F
Sbjct: 120 DPAKGMKGAIAKAEEILAKTPNGYMLQQFENPANPKIHYETTGPEIW---KGTGGKIDGF 176
Query: 192 TCSXXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQG 251
K+LKE N N KL +P S I S K G +GIG G
Sbjct: 177 VSGIGTGGTITGAGKYLKE-QNANVKLYGVEPVESAILSGGK------PGPHKIQGIGAG 229
Query: 252 RITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPE- 310
I + +VD+ D+ V + +ESI M +L +EGL VG ++ AA K+AQ PE
Sbjct: 230 FIPSVL--NVDLIDEVVQVSSDESIDMARQLALKEGLLVGISSGAAAAAAIKLAQR-PEN 286
Query: 311 -GSNVATILCDSGHKYADRV 329
G I G +Y V
Sbjct: 287 AGKLFVAIFPSFGERYLSTV 306
>At3g22460 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 321
Score = 139 bits (349), Expect = 8e-33
Identities = 112/326 (34%), Positives = 156/326 (47%), Gaps = 30/326 (9%)
Query: 10 VPPLANKGFTDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKK 69
V P K T+ IG+TPL+ + +++K+ ++ K E+ P SVKDR +I DAE K
Sbjct: 4 VAPKIAKDVTELIGNTPLVYLNKVAKDCVGHVAAKLEMMEPCSSVKDRIGYSMIADAEAK 63
Query: 70 GLIDPSRPVTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPV 129
GLI P V ++E ++GNT +GLA AKGY V MP + S + +L GAE+
Sbjct: 64 GLIKPGESV-LIEPTSGNTGVGLAFTAAAKGYKLVITMPASMSIERRIILLAFGAELI-- 120
Query: 130 PVCPITDPLNFNN----RARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAG 185
+TDP +A + + N QF+N +N K HY TT PEI + +G
Sbjct: 121 ----LTDPAKGMKGAVAKAEEILAKTPNGYMLQQFENPANPKIHYETTGPEIW---KGSG 173
Query: 186 MMLDAFTCSXXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFT 245
+D F K+LKE N N KL +P S I S K G
Sbjct: 174 GKVDGFV----SGIGTGGAGKYLKE-QNTNIKLYGVEPVESPILSGGK------PGPHKI 222
Query: 246 EGIGQGRITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVA 305
+GIG G I + VD+ D+ V + EESI M L EEGL VG ++ AA K+A
Sbjct: 223 QGIGAGFIPGIL--DVDLIDEVVQVSSEESIDMARLLAREEGLLVGISSGAAATAAIKLA 280
Query: 306 QTLPE--GSNVATILCDSGHKYADRV 329
+ PE G + + G +Y V
Sbjct: 281 KR-PENAGKLIVAVFPSFGERYLSTV 305
>At5g28030 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 323
Score = 137 bits (344), Expect = 3e-32
Identities = 104/316 (32%), Positives = 153/316 (47%), Gaps = 20/316 (6%)
Query: 13 LANKGFTDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLI 72
L T+ IG+TP++ + ++ I K E+ P S+KDR A +I+DAE KGLI
Sbjct: 6 LIKNDVTELIGNTPMVYLNKIVDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLI 65
Query: 73 DPSRPVTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPV- 131
P + T++E + GNT IGLA I ++GY + MP T S + +L+ LGAEV+ +
Sbjct: 66 TPGKS-TLIEATGGNTGIGLASIGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDIS 124
Query: 132 CPITDPLNFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAF 191
I L +A++ + QF N N + HY TT PEI + + AG +D
Sbjct: 125 IGIKGQL---EKAKEILSKTPGGYIPHQFINPENPEIHYRTTGPEIWR--DSAG-KVDIL 178
Query: 192 TCSXXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQG 251
KFLKE N + K+ V +P S + S K G +GIG G
Sbjct: 179 VAGVGTGGTVTGTGKFLKE-KNKDIKVCVVEPSESAVLSGGK------PGPHLIQGIGSG 231
Query: 252 RITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPE- 310
I N+ + I D+ + + EE+I L +EGL VG ++ + AA KVA+ PE
Sbjct: 232 EIPANL--DLSIVDEIIQVTGEEAIETTKLLAIKEGLLVGISSGASAAAALKVAKR-PEN 288
Query: 311 -GSNVATILCDSGHKY 325
G + I G +Y
Sbjct: 289 VGKLIVVIFPSGGERY 304
>At3g59760 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 442
Score = 135 bits (341), Expect = 7e-32
Identities = 99/285 (34%), Positives = 142/285 (49%), Gaps = 15/285 (5%)
Query: 22 IGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVTVV 81
IG TP++ + ++K NI K E+ P SVKDR ++ DAE+KG I P + V +V
Sbjct: 121 IGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSV-LV 179
Query: 82 EGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPLNFN 141
E ++GNT IGLA I ++GY + MP + S + LLK GAE+ V P
Sbjct: 180 EPTSGNTGIGLAFIAASRGYRLILTMPASMSMERRVLLKAFGAEL--VLTDPAKGMTGAV 237
Query: 142 NRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXXXXXXX 201
+A + K +A QFDN +N K HY TT PEI ++ +D F
Sbjct: 238 QKAEEILKNTPDAYMLQQFDNPANPKIHYETTGPEIW---DDTKGKVDIFVAGIGTGGTI 294
Query: 202 XXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRITENMRQSV 261
V +F+KE N +++ +P S I S K G +GIG G I +N+ Q
Sbjct: 295 TGVGRFIKE-KNPKTQVIGVEPTESDILSGGK------PGPHKIQGIGAGFIPKNLDQK- 346
Query: 262 DITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQ 306
I D+ + I EE+I +L +EGL VG ++ AA KVA+
Sbjct: 347 -IMDEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAK 390
>At2g43750 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 392
Score = 135 bits (339), Expect = 1e-31
Identities = 103/307 (33%), Positives = 152/307 (48%), Gaps = 20/307 (6%)
Query: 22 IGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVTVV 81
IG TP++ + + K ++ K E+ P SVKDR +I DAE+KGLI P + V +V
Sbjct: 83 IGKTPMVYLNNVVKGCVASVAAKLEIMEPCCSVKDRIGYSMITDAEEKGLITPGKSV-LV 141
Query: 82 EGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAE-VYPVPVCPITDPLNF 140
E ++GNT IGLA I +KGY + MP + S + LL+ GAE V P +T +
Sbjct: 142 ESTSGNTGIGLAFIAASKGYKLILTMPASMSLERRVLLRAFGAELVLTEPAKGMTGAI-- 199
Query: 141 NNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXXXXXX 200
+A + K+ N+ QFDN +N K HY TT PEI E+ +D
Sbjct: 200 -QKAEEILKKTPNSYMLQQFDNPANPKIHYETTGPEIW---EDTRGKIDILVAGIGTGGT 255
Query: 201 XXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRITENMRQS 260
V +F+KE K++ +P S I S K G +GIG G + +N+
Sbjct: 256 ITGVGRFIKE-RKPELKVIGVEPTESAILSGGK------PGPHKIQGIGAGFVPKNL--D 306
Query: 261 VDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPE--GSNVATIL 318
+ I D+ + I EE+I +L +EGL VG ++ AA +VA+ PE G +A +
Sbjct: 307 LAIVDEYIAISSEEAIETSKQLALQEGLLVGISSGAAAAAAIQVAKR-PENAGKLIAVVF 365
Query: 319 CDSGHKY 325
G +Y
Sbjct: 366 PSFGERY 372
>CE16252 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 337
Score = 134 bits (337), Expect = 2e-31
Identities = 100/308 (32%), Positives = 159/308 (51%), Gaps = 18/308 (5%)
Query: 20 DAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVT 79
+ IG+TPL+K+ ++ K+LG +I K E NP SVKDR A +I+ AEK GLI P + V
Sbjct: 12 ELIGNTPLLKLNKIGKDLGASIAVKVEYMNPACSVKDRIAFNMIDTAEKAGLITPGKTV- 70
Query: 80 VVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPLN 139
++E ++GN I LA+ K +GY + MP + S + LLK GAEV + P T
Sbjct: 71 LIEPTSGNMGIALAYCGKLRGYKVILTMPASMSIERRCLLKAYGAEV--ILTDPATAVKG 128
Query: 140 FNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXXXXX 199
RA + + NA +QF N +N +AHY TT PEI +Q + +D
Sbjct: 129 AVQRAEELRDVIPNAYILNQFGNPANPEAHYKTTGPEIWRQTQG---KVDIVCFGVGSGG 185
Query: 200 XXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRITENMRQ 259
V +FLKE N + ++ +P S + + + K +G+G G I + +
Sbjct: 186 TCTGVGRFLKE-KNPSVQVFPVEPFESSVINGLPHSPHK------IQGMGTGMIPDIL-- 236
Query: 260 SVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPE--GSNVATI 317
+ + +A+ + +++I M +L DEE + G ++ NV AA ++A+ PE G + T
Sbjct: 237 DLTLFSEALRVHSDDAIAMAKKLADEESILGGISSGANVCAAVQLAKR-PENKGKLIVTT 295
Query: 318 LCDSGHKY 325
+ G +Y
Sbjct: 296 VNSFGERY 303
>CE08286 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 344
Score = 133 bits (335), Expect = 3e-31
Identities = 104/310 (33%), Positives = 150/310 (47%), Gaps = 26/310 (8%)
Query: 22 IGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVTVV 81
IG+TP++ I +L+K L + K E NP GSVKDR ++ AEK G + P T++
Sbjct: 18 IGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPG-VTTLI 76
Query: 82 EGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPLNFN 141
E ++GNT I LA + AKGY + MP + S + LLK G+EV +TDP
Sbjct: 77 EPTSGNTGIALAFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVV------LTDPAKGM 130
Query: 142 NRARDHAKRL----DNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXXX 197
A D A +L ++ QFDN +N HY TT PEI +Q + +DA
Sbjct: 131 KGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPEIWRQTKGT---VDAVVFGVGT 187
Query: 198 XXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRITENM 257
V ++L+E N ++ +P S I S + G +GIG G +
Sbjct: 188 GGTITGVGRYLQE-QNPGVRVFAVEPEESAILSG------RPAGPHKIQGIGAGFAPAVL 240
Query: 258 RQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPE--GSNVA 315
I +D + I +E+I+M RL EEGL G ++ NV AA ++A PE G +
Sbjct: 241 --DTKIYEDVIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLA-ARPEMAGKLIV 297
Query: 316 TILCDSGHKY 325
T L G +Y
Sbjct: 298 TCLPSCGERY 307
>At3g04940 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 399
Score = 133 bits (334), Expect = 5e-31
Identities = 103/323 (31%), Positives = 157/323 (47%), Gaps = 26/323 (8%)
Query: 19 TDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPV 78
T IG+TP++ + + I K E+ P SVK+R A +I+DAE KGLI P +
Sbjct: 88 TQLIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKERIAYGMIKDAEDKGLITPGKS- 146
Query: 79 TVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDP- 137
T++E ++GNT IGLA I AKGY V MP + S + +L LGAEV+ +TDP
Sbjct: 147 TLIEATSGNTGIGLAFIGAAKGYKVVLTMPSSMSLERKIILLALGAEVH------LTDPS 200
Query: 138 ---LNFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCS 194
++A + + +++ +QF N SN + HY TT PEI + + AG +D
Sbjct: 201 KGVQGIIDKAEEICSKNPDSIMLEQFKNPSNPQTHYRTTGPEIWR--DSAG-EVDILVAG 257
Query: 195 XXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRIT 254
+FLKE N + K+ +P S + S K G +GIG G I
Sbjct: 258 VGTGGTLSGSGRFLKE-KNKDFKVYGVEPTESAVISGGK------PGTHLIQGIGAGLIP 310
Query: 255 ENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPEGSNV 314
+N+ ++ D+ + + E+I L +EGL VG ++ AA KVA+ +
Sbjct: 311 DNL--DFNVLDEVIQVTSVEAIETAKLLALKEGLLVGISSGAAAAAAIKVAKRPENAGKL 368
Query: 315 ATILCDSGHKYADRVFSKSWLQS 337
++ SG +R S S +S
Sbjct: 369 IVVIFPSG---GERYLSTSLFES 388
>CE11452 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 337
Score = 132 bits (331), Expect = 1e-30
Identities = 105/335 (31%), Positives = 163/335 (48%), Gaps = 32/335 (9%)
Query: 20 DAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVT 79
D +G+TPL+ ++ ++K L I K E NP SVKDR A +++DAEK G I P + V
Sbjct: 12 DTVGNTPLVLLRNITKGLDARIAVKIEYLNPSCSVKDRIAKTMVDDAEKAGKIVPGKTV- 70
Query: 80 VVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPLN 139
+VEG++GN I LAHI + +GY + M S + +L+ GAEV ++DP
Sbjct: 71 LVEGTSGNLGIALAHIGRIRGYKVILVMTTAMSIERRAMLRAYGAEVI------LSDPAE 124
Query: 140 FN----NRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSX 195
+ + +L +A DQF N SN AHY TT PEI +Q + +D
Sbjct: 125 GHPGIVKKIEMLVSKLPDAYCLDQFSNPSNPAAHYRTTGPEIWKQTQG---KVDMVCFGV 181
Query: 196 XXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRITE 255
V ++L+ A N + +P S + S G GIG G I
Sbjct: 182 GSGGTVTGVGRYLR-AQKQNIGVYPVEPFESSVLSGFP------RGPHKIHGIGAGLIPG 234
Query: 256 NMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPEGSNVA 315
N+ +S + + + E+++ M RL DEE + G ++ NVVAA ++A+ PE N+
Sbjct: 235 NVDRS--LFTEVFRVKSEDAMKMARRLADEEAILGGISSGANVVAAVELARR-PE--NIG 289
Query: 316 TILCDSGHKYADRVFSKSWLQSKKLYDVLPDHLKK 350
++ + + +A+R F S +LY L + K
Sbjct: 290 KLIVTTVNSFAERYF------STELYSTLLSEVSK 318
>At5g28020 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 323
Score = 128 bits (321), Expect = 1e-29
Identities = 101/319 (31%), Positives = 152/319 (46%), Gaps = 26/319 (8%)
Query: 13 LANKGFTDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLI 72
L T+ IG+TP++ + + I K E+ P SVKDR A +I+DAE KGLI
Sbjct: 6 LIKNDITELIGNTPMVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLI 65
Query: 73 DPSRPVTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVC 132
P + T++E +AGNT IGLA + A+GY + MP T S + +L+ LGAE++
Sbjct: 66 TPGKS-TLIEPTAGNTGIGLACMGAARGYKVILVMPSTMSLERRIILRALGAELH----- 119
Query: 133 PITDP----LNFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMML 188
++D + + QF+N +N + HY TT PEI + + AG +
Sbjct: 120 -LSDQRIGLKGMLEKTEAILSKTPGGYIPQQFENPANPEIHYRTTGPEIWR--DSAG-KV 175
Query: 189 DAFTCSXXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGI 248
D V KFLKE N + K+ V +P S + S + G +GI
Sbjct: 176 DILVAGVGTGGTATGVGKFLKE-QNKDIKVCVVEPVESPVLSG------GQPGPHLIQGI 228
Query: 249 GQGRITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTL 308
G G + N+ + I D+ + + EE+I L +EGL VG ++ AA KVA+
Sbjct: 229 GSGIVPFNL--DLTIVDEIIQVAGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKR- 285
Query: 309 PE--GSNVATILCDSGHKY 325
PE G + + G +Y
Sbjct: 286 PENAGKLIVVVFPSGGERY 304
>CE20851 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 755
Score = 126 bits (316), Expect = 6e-29
Identities = 100/339 (29%), Positives = 151/339 (44%), Gaps = 19/339 (5%)
Query: 12 PLANKGFTDAIGSTPLIKIQRLSKELGR--NIYGKSELQNPGGSVKDRAALYLIEDAEKK 69
PL DAIG TPL+K+Q + K G N+Y K E N GGS KDR A ++E AEK
Sbjct: 334 PLVLDSVLDAIGKTPLVKLQHVPKAHGVRCNVYVKCEFLNAGGSTKDRIAKKMVEIAEKT 393
Query: 70 GLIDPSRP--VTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVY 127
G P T++E ++GNT IGL+ + +GY + MP+ S+ K L LG+ +
Sbjct: 394 GKPGALTPGATTLIEPTSGNTGIGLSLVAAVRGYKCLITMPEKMSKEKSTTLSVLGSTIV 453
Query: 128 PVP-VCPITDPLNFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGM 186
P P + A + AV DQ+ N N AHY TA EIL + +
Sbjct: 454 RTPNEAAFNSPSSHIGVALRLKHEIPGAVILDQYCNPGNPLAHYEETAEEILWDMGD--R 511
Query: 187 MLDAFTCSXXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSF-- 244
+D +++ + E N +V DP GS++ T F
Sbjct: 512 KIDLVVLGAGTGGTITGISRKIHE-RRPNAIVVGVDPNGSIL-----TGPTTGPAPDFYE 565
Query: 245 TEGIGQGRITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKV 304
EGIG I + + D + D+ES +M ++ EG+ GG++ V A +
Sbjct: 566 VEGIGYDFIPGTLDEK--SVDSWLKSDDKESFLMAREIIRTEGILCGGSSGCAVHYALEQ 623
Query: 305 AQ--TLPEGSNVATILCDSGHKYADRVFSKSWLQSKKLY 341
+ LPE +NV +L D Y + W++++ +
Sbjct: 624 CRKLDLPEDANVVVLLPDGIRNYLTKFLDDDWMKARGFF 662
>CE25661 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 700
Score = 122 bits (305), Expect = 1e-27
Identities = 100/337 (29%), Positives = 150/337 (43%), Gaps = 15/337 (4%)
Query: 12 PLANKGFTDAIGSTPLIKIQRLSKELGR--NIYGKSELQNPGGSVKDRAALYLIEDAEKK 69
PL DAIG TPL+K+Q + K G N+Y K E N GGS KDR A ++E AEK
Sbjct: 372 PLVLDTVLDAIGKTPLVKLQHIPKAHGVKCNVYVKCEYMNAGGSTKDRIAKRMVEIAEKT 431
Query: 70 GLIDPSRP-VTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYP 128
G P VT++E ++GNT IGL+ +GY + MP S+ K + LG+ +
Sbjct: 432 GKPGKLVPGVTLIEPTSGNTGIGLSLASAVRGYKCIITMPKKMSKEKSIAMASLGSTIIR 491
Query: 129 VP-VCPITDPLNFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMM 187
P P + A + +AV DQ+ N N AHY TA EI+ + +
Sbjct: 492 TPNEAGFDSPHSHIGVALRLKSEIQDAVVLDQYCNPGNPLAHYEETAEEIIYDMGD--KH 549
Query: 188 LDAFTCSXXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEG 247
+D + +++ + E K+V DP GS++ +T E EG
Sbjct: 550 IDLVVLTAGTGGTVTGISRKIHERI-PTAKVVGVDPHGSILAGPAETDIDFYE----VEG 604
Query: 248 IGQGRITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQT 307
IG + + S D D+ES +M L+ EG+ GG++ V A + ++
Sbjct: 605 IGYDFLPGTLDTSA--IDYWAKSHDKESFLMARELIRSEGILCGGSSGCAVHYALEECKS 662
Query: 308 --LPEGSNVATILCDSGHKYADRVFSKSWLQSKKLYD 342
LP +NV +L D Y + W+ + D
Sbjct: 663 LNLPAEANVVVLLPDGIRNYITKFLDDDWMNERHFLD 699
>At3g03630 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 404
Score = 119 bits (299), Expect = 5e-27
Identities = 98/312 (31%), Positives = 142/312 (45%), Gaps = 34/312 (10%)
Query: 19 TDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPV 78
T IGSTP++ + R++ +I K E P SVKDR L +I +AE G I P R
Sbjct: 104 TQLIGSTPMVYLNRVTDGCLADIAAKLESMEPCRSVKDRIGLSMINEAENSGAITP-RKT 162
Query: 79 TVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPL 138
+VE + GNT +G+A + AKGY + MP + + + LL+ LGAE+ +T+P
Sbjct: 163 VLVEPTTGNTGLGIAFVAAAKGYKLIVTMPASINIERRMLLRALGAEIV------LTNPE 216
Query: 139 NFNNRARDHAKRL----DNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCS 194
A D AK + NA QFDN +N K H+ TT PEI E+ +D F
Sbjct: 217 KGLKGAVDKAKEIVLKTKNAYMFQQFDNTANTKIHFETTGPEIW---EDTMGNVDIFVAG 273
Query: 195 XXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRIT 254
FLK N + K+V +P + S + + GI
Sbjct: 274 IGTGGTVTGTGGFLK-MMNKDIKVVGVEPSERSVIS--------GDNPGYLPGI------ 318
Query: 255 ENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPEGSNV 314
V + D+ + + E+I M RL EEGL VG ++ VAA +A+ +
Sbjct: 319 ----LDVKLLDEVFKVSNGEAIEMARRLALEEGLLVGISSGAAAVAAVSLAKRAENAGKL 374
Query: 315 ATILCDS-GHKY 325
T+L S G +Y
Sbjct: 375 ITVLFPSHGERY 386
>At3g61440 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 368
Score = 111 bits (278), Expect = 1e-24
Identities = 95/314 (30%), Positives = 147/314 (46%), Gaps = 26/314 (8%)
Query: 22 IGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVTVV 81
IG TPL+ + ++++ + K E P S+KDR A+ +I DAEKK LI P + T++
Sbjct: 57 IGKTPLVFLNKVTEGCEAYVAAKQEHFQPTCSIKDRPAIAMIADAEKKKLIIPGK-TTLI 115
Query: 82 EGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPL--- 138
E ++GN I LA + KGY + MP S + ++ GAE+ +TDP
Sbjct: 116 EPTSGNMGISLAFMAAMKGYRIIMTMPSYTSLERRVTMRSFGAELV------LTDPAKGM 169
Query: 139 -NFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXXX 197
+A D +A QF N +N + H+ TT PEI E+ +D F
Sbjct: 170 GGTVKKAYDLLDSTPDAFMCQQFANPANTQIHFDTTGPEIW---EDTLGNVDIFVMGIGS 226
Query: 198 XXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFTEGIGQGRITENM 257
V ++LK + N N K+ +P S I + K G G G G E +
Sbjct: 227 GGTVSGVGRYLK-SKNPNVKIYGVEPAESNILNGGK------PGPHAITGNGVGFKPEIL 279
Query: 258 RQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQTLPE--GSNVA 315
+D+ + + + E++I M L +EGL VG ++ N VAA ++A+ +PE G +
Sbjct: 280 --DMDVMESVLEVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAK-MPENKGKLIV 336
Query: 316 TILCDSGHKYADRV 329
TI G +Y V
Sbjct: 337 TIHASFGERYLSSV 350
>CE19600 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 431
Score = 65.1 bits (157), Expect = 2e-10
Identities = 80/347 (23%), Positives = 141/347 (40%), Gaps = 31/347 (8%)
Query: 22 IGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVTVV 81
+GSTP+ I R ++ K+E + GS+K R + L+ A +G + V
Sbjct: 66 MGSTPIHVIDPPGLPSVRLVF-KNESASLTGSLKHRYSWSLMMWALLEGHV--KNGTHVF 122
Query: 82 EGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCP---ITDPL 138
E S+GNTA L ++C+ G +PDT + K+ ++ V VP+ I + L
Sbjct: 123 EASSGNTACSLGYMCRLLGLQFTAVVPDTIEQVKVRRIEEQEGFVVRVPISDRLIIAEQL 182
Query: 139 NFNNRARDHAKRLDNAVWTDQFDNQSNWKAHYHTTAP-EILQQIEEAGMMLDAFTCSXXX 197
+ + NA ++F + + E+ Q+ + F
Sbjct: 183 A-KSTGGFFMNQFKNAFHAEEFHESGSASSKPSANLMHELFHQLNSTPPSI--FVHPAGT 239
Query: 198 XXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSF------TEGIGQG 251
+ ++ K+ + ++V+AD S+ Y Y+ + G+ GIG G
Sbjct: 240 GGTLSSIGRYAKKY-GLDTEIVLADTQYSIYYDYVLNGTFSKNTGAHHWVAPGMAGIGYG 298
Query: 252 -----RITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAKVAQ 306
+I E + D + IPD S + ++ + G+ G +T +N +AA +
Sbjct: 299 AMGPAQIAETTSLDPAVIDRVLKIPDLASTAAM-KVARDVGINGGTSTGVNFLAALHIGA 357
Query: 307 TL-------PEGSNVATILCDSGHKYADRVFSKSWLQSK-KLYDVLP 345
+ E +ATIL DSG Y F++ W+ K K + LP
Sbjct: 358 LIRAQNPKNQEIFTIATILADSGKYYETTYFNRKWISEKFKTHGGLP 404
>CE05602 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 435
Score = 64.3 bits (155), Expect = 3e-10
Identities = 75/347 (21%), Positives = 142/347 (40%), Gaps = 43/347 (12%)
Query: 22 IGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVTVV 81
+G TP+ K +I+ K+E ++K R A L+ A +G + S+ V
Sbjct: 57 MGHTPMTKFSPPGFP-NADIFFKNETATATRTLKHRFAWALLLWAITEGKVT-SKTSAVY 114
Query: 82 EGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPLNFN 141
+ ++GNT A++C + D + K+ ++ G ++ VPV N
Sbjct: 115 DSTSGNTGSAEAYMCTLVNVPYYAVVADNLEKEKVKQIESFGGKIIKVPVA------LRN 168
Query: 142 NRARDHAKRLDNAVWTDQFDNQSNWKAH-------------YHTTAPEILQQIEEAGMML 188
+A++ A + ++ + +QF N + YH ++ + E+ +
Sbjct: 169 AKAKEFADK-NHGFYMNQFGNAEKAEEFHESGDFYFESTNVYHEIIVQLKKDKEQIVKIP 227
Query: 189 DAFTCSXXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGS----- 243
D F S V +++ K+V++D S+ Y Y+ + + G+
Sbjct: 228 DYFVHSAGTGGTISSVGRYVAR-YGAPTKVVLSDSQYSLFYDYVIGHKFTNQSGAGIWTP 286
Query: 244 -FTEGIGQGR------ITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTAL 296
GIG G E + ++ +A+ +PD S+ + R+LDE+G VG +T+L
Sbjct: 287 PGIAGIGYGYDIEPVWYGETTSLTRNVIHEAMKMPDIASVATM-RILDEKGYNVGPSTSL 345
Query: 297 N-VVAAAKVAQTLPEGS------NVATILCDSGHKYADRVFSKSWLQ 336
N +V+ K Q S + T+ CD G Y + W++
Sbjct: 346 NFLVSLYKAYQNKARKSAIKHRLTIVTLACDPGDFYRSTYLNNEWVE 392
>CE09160 [E] KOG1252 Cystathionine beta-synthase and related enzymes
Length = 430
Score = 57.0 bits (136), Expect = 4e-08
Identities = 74/347 (21%), Positives = 141/347 (40%), Gaps = 32/347 (9%)
Query: 22 IGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVTVV 81
+G TPL+K +I+ K+E + ++K R A L+ A +G + S+ V
Sbjct: 56 MGHTPLVKFSPPGFP-NTDIFFKNETVSATRTLKHRFAWALLLWAIVEGKVT-SKTSAVY 113
Query: 82 EGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPLN-- 139
+ ++GN A++C G + + + KI+ ++ G +V VP T N
Sbjct: 114 DATSGNMGSAEAYMCTLVGIPYFAVVSEECEQEKIDNIEKFGGKVIKVPTALRTTKSNEF 173
Query: 140 -FNNRARDHAKRLDNAVWTDQFDNQSNWKAH-----YHTTAPEILQQIEEAGMMLDAFTC 193
N + + NA ++F ++ + +H ++ ++ + D F
Sbjct: 174 AIENNG-FYINQQKNAALAEEFHESGDFINYESSNVFHEILVQLKDNEKQTSKVPDFFVH 232
Query: 194 SXXXXXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYIKTRELKREGGSFT------EG 247
V +++ + K+V+AD SV Y Y+ + + G G
Sbjct: 233 PAGTGGTVSSVGRYVVK-YGLPTKVVLADSQFSVYYDYVIGNKFTNQTGEKVWRAPGIAG 291
Query: 248 IGQG------RITENMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALN-VVA 300
G G + E + ++ ++A+ +PD ++ + R+L+E G G +T+LN +V
Sbjct: 292 TGYGYDIVPIQYGETTSLTKNVINEAMKMPDIATVAAM-RILNEMGYNAGASTSLNFLVC 350
Query: 301 AAKVAQTLPEGSN------VATILCDSGHKYADRVFSKSWLQSKKLY 341
K QT + SN +AT+ D G Y W+ + Y
Sbjct: 351 LYKAYQTKQKSSNNEYQLTIATLAGDPGDFYHSTYLDDGWVDTHLNY 397
>SPBC1677.03c [E] KOG1250 Threonine/serine dehydratases
Length = 600
Score = 52.0 bits (123), Expect = 1e-06
Identities = 79/309 (25%), Positives = 120/309 (38%), Gaps = 21/309 (6%)
Query: 20 DAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVT 79
+ I TPL K +S+ G +Y K E P S K R A + +K+ L +
Sbjct: 109 EVIKETPLTKGVVISESTGVPVYLKREDLTPVFSFKIRGAHNKMASLDKQSLKNG----- 163
Query: 80 VVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPLN 139
V+ SAGN A G+A+ + G A MP E K +K LGA V + N
Sbjct: 164 VIACSAGNHAQGVAYSARTLGVKATIVMPQNTPEIKWRNVKRLGANV-------LLHGAN 216
Query: 140 FNNRARDHAK--RLDNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLDAFTCSXXX 197
F+ + A+ + N FD+ A T EIL QI+ LDA C+
Sbjct: 217 FDIAKAECARLAKEQNLEVIHPFDD-PYVIAGQGTIGLEILHQIDL--RKLDAIYCAVGG 273
Query: 198 XXXXXXVAKFLKEATNGNCKLVVADPPGSVIYSYI--KTRELKREGGSFTEGIGQGRITE 255
+A ++K + V + + K R +E G F +G + E
Sbjct: 274 GGLIAGIATYVKRIAPHVKVIGVETFDADALKKSLKDKKRVTLKEVGLFADGTAVKLVGE 333
Query: 256 NMRQSVDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVAAAK--VAQTLPEGSN 313
+ V D V + D++ I + + + V + VA K VA+ P+ N
Sbjct: 334 ETFRLVSKNIDDVVLVDKDEICAAIKDVFLDTRSVVEPSGAMAVAGMKRYVAKHKPKNPN 393
Query: 314 VATILCDSG 322
A + SG
Sbjct: 394 AAQVCILSG 402
>CE26153 [E] KOG1250 Threonine/serine dehydratases
Length = 448
Score = 51.6 bits (122), Expect = 2e-06
Identities = 78/318 (24%), Positives = 129/318 (40%), Gaps = 36/318 (11%)
Query: 13 LANKGFTDAIGSTPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLI 72
+A+ + I T K + LSK NIY K E+ GS K+R A Y +++ L
Sbjct: 46 MAHHRIQNGIVRTDCRKSRCLSKLFDMNIYLKMEVNQDTGSFKERGARYALQN-----LP 100
Query: 73 DPSRPVTVVEGSAGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVC 132
+ + V SAGN A+ L+ K G MP KIN + LGA + V
Sbjct: 101 EEKKKAGVYAASAGNHALALSLHGKQLGVEVNVVMPKIAPLMKINRCQDLGANIL-VQGE 159
Query: 133 PITDPLNFNNRARDHAKRL---DNAVWTDQFDNQSNWKAHYHTTAPEILQQIEEAGMMLD 189
I + +R+ A R+ N + + +D+ + A TT EIL+QI+ M D
Sbjct: 160 DIAE-------SREIALRMAHDSNGTYINGYDHY-DILAGAGTTGIEILEQIQ----MPD 207
Query: 190 AFTCSXXXXXXXXXVAKFLKEATNGNCKL-VVADPPGSVIYS-------YIKTRELKREG 241
A VA +K + + VV++ +++ S Y TR
Sbjct: 208 AILVPVGGGGLVAGVATAVKALSPTTEVIGVVSETCQAIVKSLQAGHPVYTPTRP----- 262
Query: 242 GSFTEGIGQGRITENMRQS-VDITDDAVFIPDEESIIMLFRLLDEEGLFVGGTTALNVVA 300
+ +G+ N S + D + +P+ + + + RL++ E + G A+ + A
Sbjct: 263 -TLADGLAVPNAGVNAFASMIGKVDRVISVPENDIAVAILRLIENEKVVCEGAGAIGIGA 321
Query: 301 AAKVAQTLPEGSNVATIL 318
+G V +IL
Sbjct: 322 ILSGKLNHLKGKTVVSIL 339
>Hs19923959 [E] KOG1250 Threonine/serine dehydratases
Length = 329
Score = 50.1 bits (118), Expect = 5e-06
Identities = 44/145 (30%), Positives = 64/145 (43%), Gaps = 11/145 (7%)
Query: 25 TPLIKIQRLSKELGRNIYGKSELQNPGGSVKDRAALYLIEDAEKKGLIDPSRPVTVVEGS 84
TPL++ LS+ G ++ K E P GS K R + ++ KKG +V S
Sbjct: 18 TPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMAKKGCRH------LVCSS 71
Query: 85 AGNTAIGLAHICKAKGYNAVFYMPDTQSEAKINLLKWLGAEVYPVPVCPITDPLNFNNRA 144
GN I A+ + G A +P++ S + L+ GAEV + D N RA
Sbjct: 72 GGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTG--KVWDEANL--RA 127
Query: 145 RDHAKRLDNAVWTDQFDNQSNWKAH 169
++ AKR D FD+ WK H
Sbjct: 128 QELAKR-DGWENVPPFDHPLIWKGH 151
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.135 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,530,507
Number of Sequences: 60738
Number of extensions: 891926
Number of successful extensions: 2050
Number of sequences better than 1.0e-05: 28
Number of HSP's better than 0.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1949
Number of HSP's gapped (non-prelim): 34
length of query: 355
length of database: 30,389,216
effective HSP length: 107
effective length of query: 248
effective length of database: 23,890,250
effective search space: 5924782000
effective search space used: 5924782000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)