ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0570 check: MH T KOG1450 Signal transduction mechanisms Predicted Rho GTPase-activating protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0570 191154 193187 678
(678 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBR260c [T] KOG1450 Predicted Rho GTPase-activating protein 780 0.0
SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein 192 1e-48
CE00918 [T] KOG1450 Predicted Rho GTPase-activating protein 99 3e-20
Hs11641401 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 98 5e-20
Hs14210510 [T] KOG1450 Predicted Rho GTPase-activating protein 96 1e-19
Hs10835201 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 95 4e-19
Hs11038641 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 94 7e-19
Hs11038639 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 94 7e-19
Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein 90 1e-17
Hs5902012_2 [T] KOG1453 Chimaerin and related Rho GTPase activat... 89 2e-17
CE26357 [R] KOG4407 Predicted Rho GTPase-activating protein 88 5e-17
Hs5803145 [T] KOG4370 Ral-GTPase effector RLIP76 87 1e-16
SPAC29A4.11_2 [T] KOG1453 Chimaerin and related Rho GTPase activ... 86 1e-16
Hs20977541 [R] KOG4407 Predicted Rho GTPase-activating protein 84 7e-16
7289304 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 83 1e-15
Hs4502813 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 82 2e-15
Hs4757980 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 82 3e-15
CE03768 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 80 8e-15
Hs22050706 [T] KOG4271 Rho-GTPase activating protein 79 2e-14
CE23779_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 79 2e-14
YER155c [T] KOG1450 Predicted Rho GTPase-activating protein 78 4e-14
7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr 78 4e-14
Hs20536040 [T] KOG4270 GTPase-activator protein 76 1e-13
7293122 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activa... 76 1e-13
Hs4502221 [T] KOG4271 Rho-GTPase activating protein 76 2e-13
Hs22045949 [T] KOG1449 Predicted Rho GTPase-activating protein C... 76 2e-13
7295587 [R] KOG4407 Predicted Rho GTPase-activating protein 75 4e-13
SPAC26A3.09 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 74 6e-13
Hs7662208 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-acti... 74 7e-13
Hs21264597 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 74 1e-12
Hs16975484 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 74 1e-12
Hs16163690 [Z] KOG3565 Cdc42-interacting protein CIP4 74 1e-12
Hs4505507 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-acti... 73 1e-12
7293306 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3 73 2e-12
SPBC28E12.03_2 [T] KOG1453 Chimaerin and related Rho GTPase acti... 72 4e-12
Hs4757766 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 70 8e-12
Hs7656904 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 70 1e-11
CE28644 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activa... 70 1e-11
CE09612 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3 70 1e-11
CE16059 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr 69 2e-11
Hs22040999 [Z] KOG3565 Cdc42-interacting protein CIP4 69 3e-11
Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4 68 5e-11
Hs4758750_2 [T] KOG1453 Chimaerin and related Rho GTPase activat... 68 5e-11
7294614 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 67 9e-11
HsM16975482 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ... 66 2e-10
Hs21264594 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 66 2e-10
Hs21264592 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 66 2e-10
Hs20540662 [T] KOG4271 Rho-GTPase activating protein 66 2e-10
CE18872 [R] KOG3564 GTPase-activating protein 66 2e-10
Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 65 3e-10
Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 65 3e-10
Hs13775230 [T] KOG4270 GTPase-activator protein 64 8e-10
Hs21361397 [R] KOG3564 GTPase-activating protein 63 1e-09
CE20680 [Z] KOG3565 Cdc42-interacting protein CIP4 62 2e-09
HsM7019433 [R] KOG3564 GTPase-activating protein 62 3e-09
Hs7662242 [T] KOG4270 GTPase-activator protein 62 3e-09
Hs21314774 [T] KOG4724 Predicted Rho GTPase-activating protein 62 4e-09
7290597 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 61 6e-09
Hs20270373 [T] KOG4724 Predicted Rho GTPase-activating protein 60 8e-09
7303262 [R] KOG3564 GTPase-activating protein 60 8e-09
Hs21264337_1 [TZ] KOG1117 Rho- and Arf-GTPase activating protein... 60 1e-08
HsM19923515 [T] KOG4270 GTPase-activator protein 60 1e-08
Hs7382484 [TZ] KOG2710 Rho GTPase-activating protein 60 1e-08
Hs7382482 [TZ] KOG2710 Rho GTPase-activating protein 60 1e-08
Hs7382480 [TZ] KOG2710 Rho GTPase-activating protein 60 1e-08
Hs7382478 [TZ] KOG2710 Rho GTPase-activating protein 60 1e-08
Hs4758882 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 60 1e-08
Hs4502223 [TZ] KOG2710 Rho GTPase-activating protein 60 1e-08
Hs21361736 [T] KOG4270 GTPase-activator protein 60 1e-08
Hs15147252 [T] KOG4270 GTPase-activator protein 59 2e-08
CE06642 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 59 2e-08
CE06641 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 59 2e-08
7302107 [T] KOG1452 Predicted Rho GTPase-activating protein 59 3e-08
7293370 [T] KOG4271 Rho-GTPase activating protein 58 4e-08
YDR379w_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 58 5e-08
Hs7706107 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 57 7e-08
7300563 [T] KOG4270 GTPase-activator protein 57 1e-07
Hs13491176 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 56 2e-07
YOR127w_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 56 2e-07
Hs22065906 [T] KOG4724 Predicted Rho GTPase-activating protein 56 2e-07
SPBC3F6.05_2 [TZ] KOG2710 Rho GTPase-activating protein 56 2e-07
CE17831 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 54 6e-07
CE01007 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 54 6e-07
CE21517 [T] KOG4270 GTPase-activator protein 54 8e-07
Hs14042955 [R] KOG3564 GTPase-activating protein 54 1e-06
At5g19390 [T] KOG4271 Rho-GTPase activating protein 54 1e-06
Hs7661882 [T] KOG4270 GTPase-activator protein 53 1e-06
At5g12150 [T] KOG4271 Rho-GTPase activating protein 53 2e-06
Hs16445031 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 52 3e-06
Hs20560839_1 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-a... 52 3e-06
>YBR260c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 666
Score = 780 bits (2014), Expect = 0.0
Identities = 404/657 (61%), Positives = 497/657 (75%), Gaps = 24/657 (3%)
Query: 27 LLQREEVKKVLSSDIAINALLSRLKGSLLTCEEFTKFMRKKYLYEEEHAQEMSKTTKHFF 86
L E+KKVL+SD+AINALLSRLK SLLTCEEF KF+RKKY +EEEH QE+SK KHFF
Sbjct: 29 LFSTPEIKKVLNSDVAINALLSRLKQSLLTCEEFMKFIRKKYAFEEEHVQELSKQYKHFF 88
Query: 87 QETG--NSGLSRSIHQLLEYDNKLSQVKISYVRALQKIYDEVTALLLTVTKTRKSLKEKS 144
G NS L + IH++L +D K++QVK SY+ ALQK+Y E+++LLLT+TK RKS+KE S
Sbjct: 89 NIQGSTNSSLKKMIHEVLGFDGKMAQVKQSYITALQKMYSEISSLLLTMTKLRKSVKENS 148
Query: 145 RRLEKDVSDAIHTAEKAKSRYISLCQDWEKLRLTDPTKTKLTLRGSKTTKEQEEDLQRKI 204
+RLEKDVSDAIH+AEKA+SRY SLCQDW+KLR+TDPTKTKLTLRGSKTTKEQEE+L RKI
Sbjct: 149 KRLEKDVSDAIHSAEKAQSRYNSLCQDWDKLRMTDPTKTKLTLRGSKTTKEQEEELLRKI 208
Query: 205 DSADLEYKQRVDHSNSLRNTFLSKERPQIVSELKDLILEIDTAMSIQLQKYTIWTENMIL 264
D+ADLEYKQ+VDHSNSLRNTF++KERP+IV ELKDLILEIDTAM+IQLQKYTIWTEN++L
Sbjct: 209 DNADLEYKQKVDHSNSLRNTFITKERPRIVQELKDLILEIDTAMTIQLQKYTIWTENLVL 268
Query: 265 NSGVSVNPVDGNSKSMRSSATSMNNELDLYNFLNKYN-TSKSGSMINKNLIPVEYKKHPS 323
N+GV+++P+D ++KSM+S A S++NE DLY+FLNKYN T K +INKNLIPV YKKHPS
Sbjct: 269 NTGVTISPLD-STKSMKSFAGSVSNERDLYSFLNKYNQTGKHSLLINKNLIPVSYKKHPS 327
Query: 324 MARSYTSSAMGTSSNFG-KISGPSNFVVNNSKNSLPKRVMSTQHESPFNXXXXXXXXXXX 382
M N G K P F V+ S+NS+PKR++ST +ESPF
Sbjct: 328 M-------------NHGQKNKSPPKFAVDPSRNSIPKRMISTHNESPF---LSSSSNTAA 371
Query: 383 XXXXXXXHXXXXXXXXXXXXXXXXXXITSTSSRP-LKSMVDVVPPSETNKKDFPTLDPRP 441
I+STS+ S + S+T TLDP
Sbjct: 372 VPNANLNSATPSLNTNKQLPPTMASSISSTSNAAGAMSPSSSIVTSDTTSSITKTLDPGN 431
Query: 442 NIRQTSVAPSVATTETMTRPPSTVQTIGSLPPGTAKDFKTFAVPLENLLDYDQDLVPAIV 501
N Q + + + RP S +QT ++PPG K+FKTF VPLE+L++++QD+VPAIV
Sbjct: 432 NSPQ--IPEELINSLDSDRPISHIQTNNNMPPGVQKNFKTFGVPLESLIEFEQDMVPAIV 489
Query: 502 RQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGS 561
RQCIYVIDK+GL+ EGIYRKSANVLDVS+LK EIDKDP+N+ MILP K ++DSDIYLVGS
Sbjct: 490 RQCIYVIDKFGLDQEGIYRKSANVLDVSKLKEEIDKDPANISMILPSKPHSDSDIYLVGS 549
Query: 562 LLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHL 621
LLKTFFA+LPD++LP+ ++ EIK CL IED TTRKN+MHG+IY LPD QYWT+RAL+FHL
Sbjct: 550 LLKTFFASLPDSVLPKALSSEIKVCLQIEDPTTRKNFMHGLIYNLPDAQYWTLRALVFHL 609
Query: 622 KRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDVNYQISAMELLFDVADQAFEPE 678
KR+L HE +NRM L+ALCIIWGPTI N +D NDVN+QI AME+L +V+DQAFEPE
Sbjct: 610 KRVLAHEAQNRMNLRALCIIWGPTIAPANPDDANDVNFQIMAMEVLLEVSDQAFEPE 666
>SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 695
Score = 192 bits (489), Expect = 1e-48
Identities = 160/685 (23%), Positives = 299/685 (43%), Gaps = 55/685 (8%)
Query: 27 LLQREEVKKVLSSDIAINALLSRLKGSLLTCEEFTKFMRKKYLYEEEHAQEMSKTTKHF- 85
+L+ +V+ +L+S++ + L R+K LLTC+E F +K+ + EEE + + K K +
Sbjct: 29 VLKEPKVEAILNSELGLAILNDRIKDYLLTCKELAGFFKKRSILEEESGKNLQKLAKSYL 88
Query: 86 --FQETGNS--GLSRSIHQLLEYDNKLSQVKISYVRALQKIYDEVTALLLTVTKTRKSLK 141
FQ +S S S+ +E +L+ ++ + L D+V + RKS+K
Sbjct: 89 ETFQSKHHSPQSFSASVITSMEIHEQLANHSLTLQKTLSAFSDQVIEFHKNAERKRKSIK 148
Query: 142 EKSRRLEKDVSDAIHTAEKAKSRYISLCQDWEKL---RLTDPTKTKLTLRGSKTTKEQ-- 196
E +++ E +A+ +K+KSR+ ++ + + T ++ K+ K+ +
Sbjct: 149 EYAKKQENAYLEAVMQMDKSKSRFKGAETEYNRALDNKNTGDSQKKVGFFKPKSNAQLTK 208
Query: 197 -EEDLQRKIDSADLEYKQRVDHSNSLRNTFLSKERPQIVSELKDLILEIDTAMSIQLQKY 255
E++ + K ++A+ + +++++ +++ L RP + + L EI++++ +Y
Sbjct: 209 LEDEARLKAENAESDMHSKIENAQNVQKQLLCIHRPNYIKQFFSLQREIESSLIANYLRY 268
Query: 256 TIWTENMILNSGVSVNPVDGNSKS--MRSSATSMNNELDLYNFLNKYNTSKSGSMINKNL 313
T E+ L +G+++ P + ++ + ++N D ++ + NKN
Sbjct: 269 TKLCESNTLLNGLTIRPQKPTPTNCGLQHALDNINANTDFVQYVLHASIKHED---NKNP 325
Query: 314 IPVEYKKHPSMARSYTSSAMGTSSNFGKISGPSNFVVN---------NSKNSLPKRVMST 364
K SY GT S+ GK + P N + + N P +
Sbjct: 326 TDASKTKIIQPPSSY-----GTGSSAGKTNPPVNPTIKVTAAIPSPLQNTNPAPSTFPNP 380
Query: 365 QHESP-FNXXXXXXXXXXXXXXXXXXHXXXXXXXXXXXXXXXXXXITSTSSRPLKSMVDV 423
SP F +S PL S +
Sbjct: 381 SVASPAFPNSSTSNPSTAPASASPLASTLKPSTANDTNGSSSSSSSNPRTSSPLASNAEN 440
Query: 424 VPPSETNKKD--FPTLDPRPNIRQTSVAPSVATTETMTRPPSTVQ----------TIGSL 471
PP PTL P I+ T++ T+ + PPS++ T S
Sbjct: 441 KPPVAQQSPPVLLPTLPP---IQTTTIQ----TSREVAPPPSSINSNRAASPFRPTSVSP 493
Query: 472 PPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRL 531
P + F L+ ++ + +P IV QC ++ +GLNL+GIYR ++ V+ L
Sbjct: 494 QPSSPTKSLLFGARLDAIILREHSNIPNIVMQCTSQVENFGLNLQGIYRVPSSSARVNML 553
Query: 532 KSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIED 591
+S+ + +P + + P++Y ++D++ V LLK FF L + L+P + ++ED
Sbjct: 554 RSQFENNP--LLQLHTPEDY-ENDVHAVADLLKIFFRELREPLIPDNHQRDFIDAGNVED 610
Query: 592 STTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNN 651
+ R++ +H I LPD Y TIR L HL +I E+ N+M L IIWGPTII
Sbjct: 611 ESRRRDAVHRAINDLPDANYSTIRHLTIHLAKIKENSDVNKMSTNNLAIIWGPTII--KQ 668
Query: 652 EDLNDVNYQISAMELLFDVADQAFE 676
+ +++ +E+L D F+
Sbjct: 669 ATIPEISSFSRTIEILIDYCFTIFD 693
>CE00918 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 837
Score = 98.6 bits (244), Expect = 3e-20
Identities = 69/245 (28%), Positives = 119/245 (48%), Gaps = 18/245 (7%)
Query: 414 SRPLKSMVDVVPPS--ETNKKDFPTLDPRPNIRQTSVAPSVATTETMTRPPSTVQTIGSL 471
SR ++ D + S ET T +PRP+ ++T + E + R T T+ SL
Sbjct: 545 SRSMRRRDDPMSQSAIETVSTSVSTDEPRPS-KETII-------EKLRRFFRTRPTVESL 596
Query: 472 PP-GTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
G K F L + ++ LVP +R VI+ GL +GIYR S N+ V +
Sbjct: 597 KEKGIYKPEPVFGSTLSAICQHENSLVPKFIRVITEVIESKGLETDGIYRVSGNLSAVQK 656
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
++ + D+D + ++ DI+++ LK FF L D L P + +E + + +
Sbjct: 657 IRCQADQDNYKALV-------SEEDIHVLTGALKLFFRELTDPLFPISLHKEYTSAMQMP 709
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPN 650
++TTR ++ +LP+ T++ L+ HL R+ H ++NRM L I++GPT+
Sbjct: 710 NATTRFKKFEELLSRLPNENRETLKMLLRHLNRVASHSSQNRMQQHNLAIVFGPTLFHNG 769
Query: 651 NEDLN 655
+ +N
Sbjct: 770 DGAVN 774
>Hs11641401 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 859
Score = 97.8 bits (242), Expect = 5e-20
Identities = 54/174 (31%), Positives = 89/174 (51%), Gaps = 5/174 (2%)
Query: 477 KDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEID 536
K F V + + ++ VP IVRQC+ ++K G+ GIYR S D+ LK+ D
Sbjct: 640 KQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFD 699
Query: 537 KDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRK 596
+ ++ ++L +D DI + LK +F LP+ LL + +++ D ++
Sbjct: 700 ANNKDILLML-----SDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKE 754
Query: 597 NYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPN 650
N M ++ LPD T L+ HLKR+ E E N+M L L ++GPT++ P+
Sbjct: 755 NCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPS 808
>Hs14210510 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 750
Score = 96.3 bits (238), Expect = 1e-19
Identities = 57/186 (30%), Positives = 96/186 (50%), Gaps = 13/186 (6%)
Query: 480 KTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKD- 538
+ F LE+L + D VP+ +R CI +DK GL+++GIYR S N+ V +L+ +D++
Sbjct: 538 QVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRER 597
Query: 539 --PSNVFMILPPKNYTDS----------DIYLVGSLLKTFFANLPDTLLPREMTEEIKTC 586
S+ + P + + DI++V LK F LP L+P + +
Sbjct: 598 AVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAA 657
Query: 587 LSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTI 646
L++ +S + + +I +P + T+R L+ HL R++ H KNRM L I++GPT+
Sbjct: 658 LALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTL 717
Query: 647 ISPNNE 652
P E
Sbjct: 718 FRPEQE 723
>Hs10835201 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 822
Score = 94.7 bits (234), Expect = 4e-19
Identities = 53/174 (30%), Positives = 87/174 (49%), Gaps = 5/174 (2%)
Query: 477 KDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEID 536
K F V + + + P IVRQC+ ++K G+ GIYR S D+ LK+ D
Sbjct: 603 KQTGVFGVKISVVTKREVQGAPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFD 662
Query: 537 KDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRK 596
+ ++ ++L +D DI + LK +F LP+ LL + +++ D ++
Sbjct: 663 ANNKDILLML-----SDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKE 717
Query: 597 NYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPN 650
N M ++ LPD T L+ HLKR+ E E N+M L L ++GPT++ P+
Sbjct: 718 NCMMHLVRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPS 771
>Hs11038641 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1227
Score = 94.0 bits (232), Expect = 7e-19
Identities = 50/177 (28%), Positives = 90/177 (50%), Gaps = 5/177 (2%)
Query: 477 KDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEID 536
K F V + + ++ VP IVRQC+ I++ G+ GIYR S D+ LK+ D
Sbjct: 1003 KQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFD 1062
Query: 537 KDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRK 596
+ +V +++ ++ D+ + LK +F LP+ L E +++ D ++
Sbjct: 1063 VNNKDVSVMM-----SEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKE 1117
Query: 597 NYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED 653
+ M ++ LP+ T L+ HLKR+ E E N+M L L ++GPT++ P+ ++
Sbjct: 1118 SCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKE 1174
>Hs11038639 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1271
Score = 94.0 bits (232), Expect = 7e-19
Identities = 50/177 (28%), Positives = 90/177 (50%), Gaps = 5/177 (2%)
Query: 477 KDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEID 536
K F V + + ++ VP IVRQC+ I++ G+ GIYR S D+ LK+ D
Sbjct: 1047 KQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFD 1106
Query: 537 KDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRK 596
+ +V +++ ++ D+ + LK +F LP+ L E +++ D ++
Sbjct: 1107 VNNKDVSVMM-----SEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKE 1161
Query: 597 NYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED 653
+ M ++ LP+ T L+ HLKR+ E E N+M L L ++GPT++ P+ ++
Sbjct: 1162 SCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKE 1218
>Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 316
Score = 90.1 bits (222), Expect = 1e-17
Identities = 62/213 (29%), Positives = 108/213 (50%), Gaps = 13/213 (6%)
Query: 458 MTRPPSTVQTIGSLPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEG 517
+TR P T+Q + G KD + F L NL + VP V+ CI ++++GL+++G
Sbjct: 104 LTRRP-TLQAVRE--KGYIKD-QVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDG 159
Query: 518 IYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPR 577
IYR S N+ + +L+ ++ D L + DI+++ LK FF LP+ L
Sbjct: 160 IYRVSGNLAVIQKLRFAVNHDEK-----LDLNDSKWEDIHVITGALKMFFRELPEPLFTF 214
Query: 578 EMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKA 637
+ + ++ R + +I +LP T++ L HL+R++E+ KNRM ++
Sbjct: 215 NHFNDFVNAIK-QEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQS 273
Query: 638 LCIIWGPTIISPNNEDLN---DVNYQISAMELL 667
+ I++GPT++ P E N YQ +EL+
Sbjct: 274 IAIVFGPTLLKPEKETGNIAVHTVYQNQIVELI 306
>Hs5902012_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1223
Score = 89.4 bits (220), Expect = 2e-17
Identities = 58/193 (30%), Positives = 98/193 (50%), Gaps = 13/193 (6%)
Query: 480 KTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDP 539
+ F V L L D+ VP +V + I I+ +GL EGIYRKS + + L+ +D D
Sbjct: 734 RQFGVELSRLTSEDRT-VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDA 792
Query: 540 SNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYM 599
+V N D +I+++ S+ K + +LP+ L+ E+ EE + +++ +
Sbjct: 793 ESV-------NLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGV 845
Query: 600 HGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTII-SPNNED----L 654
+ +I +L T+ LIFHL RI E NRM AL I++ P I+ P+ D +
Sbjct: 846 YSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSV 905
Query: 655 NDVNYQISAMELL 667
D++ + +EL+
Sbjct: 906 QDISKTTTCVELI 918
>CE26357 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 1388
Score = 87.8 bits (216), Expect = 5e-17
Identities = 54/167 (32%), Positives = 86/167 (51%), Gaps = 10/167 (5%)
Query: 494 QDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDK------DPSNVFMILP 547
+D VP IV+ C+ VI+ YG++ GIYR N V+ LK + D S V + P
Sbjct: 742 EDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDP 801
Query: 548 PKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLP 607
D+ +V SLLK F LP+ LL ++ I R + + ++ KLP
Sbjct: 802 RWR----DVNVVSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKLP 857
Query: 608 DGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDL 654
Y T+R LI HL I +H N+M + L +++GP+I+ P+++++
Sbjct: 858 RPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDDNM 904
>Hs5803145 [T] KOG4370 Ral-GTPase effector RLIP76
Length = 655
Score = 86.7 bits (213), Expect = 1e-16
Identities = 50/169 (29%), Positives = 83/169 (48%), Gaps = 12/169 (7%)
Query: 482 FAVPL----ENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDK 537
F +PL E + YD +PA+ R+CI ++KYG+ EGIYR S V LK+ D+
Sbjct: 190 FGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDR 249
Query: 538 DPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKN 597
+ S N D + V SLLK + +LP+ LL +E+ + T +
Sbjct: 250 EEST--------NLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQ 301
Query: 598 YMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTI 646
++ +LP+ Y I LI H+ ++ E + +M ++ + I+ PT+
Sbjct: 302 EFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTV 350
>SPAC29A4.11_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 841
Score = 86.3 bits (212), Expect = 1e-16
Identities = 55/204 (26%), Positives = 94/204 (45%), Gaps = 11/204 (5%)
Query: 472 PPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRL 531
PPG + F LEN L + ++P ++ C+ +D +GL +EGIYR S + V L
Sbjct: 642 PPGPSPTM--FGRSLENQLKIEGSVLPQVIAMCVSCVDAHGLEVEGIYRISGSASQVRVL 699
Query: 532 KSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIED 591
E + + + SD++ S+LKT+ LP+ ++P EE+ IE
Sbjct: 700 VDEFENGSIRM-------EHLTSDLFACTSVLKTYLHRLPEPVIPGTQYEELLEAEKIEK 752
Query: 592 STTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTII--SP 649
+ + ++ L R LI HL R+ +H KN M K + ++ PT++
Sbjct: 753 EEEKIERVVEVMKTLHPAHLSVFRFLIAHLGRVCKHAEKNLMNSKNVSTVFAPTLMRDKV 812
Query: 650 NNEDLNDVNYQISAMELLFDVADQ 673
N DL + +A++ + D D+
Sbjct: 813 NRFDLQHATKKSTALQFMLDNVDK 836
>Hs20977541 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 1957
Score = 84.0 bits (206), Expect = 7e-16
Identities = 49/175 (28%), Positives = 93/175 (53%), Gaps = 5/175 (2%)
Query: 481 TFAVPLENLLD-YDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDP 539
TF V L++ + +P IV C ++++ GL GIYR N +S ++ E++K
Sbjct: 1143 TFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGM 1202
Query: 540 SNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYM 599
+++ + ++ D+ ++ SLLK+FF LP+ L + + ED R +
Sbjct: 1203 ADIDI----QDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTL 1258
Query: 600 HGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDL 654
+I+ LP+ Y T++ L HLK + E+ KN+M + L I++GPT++ + +++
Sbjct: 1259 KRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNM 1313
>7289304 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 718
Score = 83.2 bits (204), Expect = 1e-15
Identities = 58/215 (26%), Positives = 104/215 (47%), Gaps = 11/215 (5%)
Query: 443 IRQTSVAPSVATTETMTRPPSTVQTIGSLPPGTAKDFKTFAVPLENLLDYDQDLVPAIVR 502
+ +T+ S+ TET+ S G L G+ K F + +L ++ +P I+
Sbjct: 471 LTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGALFGAKMSQVLKREKRDIPFIIG 530
Query: 503 QCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDS-----DIY 557
CI +++ G+ G YR S + D+++LK + S +M L + DI+
Sbjct: 531 ACIREVERRGMLEVGCYRVSGSASDLAKLKKAFE---SGEYMALMDAYEAEQLLREVDIH 587
Query: 558 LVGSLLKTFFANLPDTLLPREMTE---EIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTI 614
V +LKTF LP+ L ++ + + S + +TR N + + +LP +I
Sbjct: 588 SVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASI 647
Query: 615 RALIFHLKRILEHETKNRMGLKALCIIWGPTIISP 649
+++ HL R+ E ET N+M L L +++GPT++ P
Sbjct: 648 TSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRP 682
>Hs4502813 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 459
Score = 82.4 bits (202), Expect = 2e-15
Identities = 59/200 (29%), Positives = 91/200 (45%), Gaps = 8/200 (4%)
Query: 480 KTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDP 539
K ++ L L+ P +V CI I+ GLN EG+YR S + +K D+D
Sbjct: 264 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 323
Query: 540 SNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYM 599
+ + DI ++ LK +F +LP L+ + + I D + +
Sbjct: 324 EKADISVNMYE----DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETL 379
Query: 600 HGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED----LN 655
H + LP T+R L+ HLKR+ HE +N M + L I++GPT++ D LN
Sbjct: 380 HEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALN 439
Query: 656 DVNYQISAMELLFDVADQAF 675
D+ YQ +ELL D F
Sbjct: 440 DIRYQRLVVELLIKNEDILF 459
>Hs4757980 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 468
Score = 82.0 bits (201), Expect = 3e-15
Identities = 55/206 (26%), Positives = 95/206 (45%), Gaps = 20/206 (9%)
Query: 480 KTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKD- 538
K + L L+ P +V CI I+ GL EG+YR S + +K D+D
Sbjct: 273 KVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDG 332
Query: 539 -----PSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDST 593
+NV+ DI ++ LK +F +LP ++ + + I ++
Sbjct: 333 EKADISANVY----------PDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNAD 382
Query: 594 TRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED 653
R +H ++ LP Y T+R L+ HLK++ +E N M + L I++GPT++ P +
Sbjct: 383 ERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDS 442
Query: 654 ----LNDVNYQISAMELLFDVADQAF 675
L+D+ YQ +++L + D F
Sbjct: 443 TLTTLHDMRYQKLIVQILIENEDVLF 468
>CE03768 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 444
Score = 80.5 bits (197), Expect = 8e-15
Identities = 58/204 (28%), Positives = 96/204 (46%), Gaps = 11/204 (5%)
Query: 463 STVQTIGSLPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKS 522
ST PP + F VPLE +L + +P IV Q I ++ + L +EG++RKS
Sbjct: 228 STQSNRPETPPAQPLPTQQFGVPLEFILSHCGGNIPPIVDQLIEYLEAHALTMEGVFRKS 287
Query: 523 ANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYL---VGSLLKTFFANLPDTLLPREM 579
AN+ + RL+ I+K F P Y D++ LLKTFF +L + L +
Sbjct: 288 ANIGSIKRLQDRINKGEKIDFENDP--EYKDNEYVASLHASVLLKTFFRSLGEPLTTNRL 345
Query: 580 TEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALC 639
++ LS T + + + LP Y ++ +I L R+ E+ N M L
Sbjct: 346 YPKL-AALSEVSKTEKSAAVKEFVKLLPRENYILLKTVIKFLTRVAENSKVNLMTANNLS 404
Query: 640 IIWGPTIISPNNED-----LNDVN 658
+++GP + P +++ LN++N
Sbjct: 405 VVFGPNLTWPTDQEVPISQLNNLN 428
>Hs22050706 [T] KOG4271 Rho-GTPase activating protein
Length = 1499
Score = 79.3 bits (194), Expect = 2e-14
Identities = 47/169 (27%), Positives = 88/169 (51%), Gaps = 7/169 (4%)
Query: 482 FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSN 541
F VPL ++ ++ +P + +CI I+ GL+ EGIYR S N ++ L+ + D+D +
Sbjct: 1247 FGVPLTTVVTPEKP-IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHN- 1304
Query: 542 VFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHG 601
+ L K++T + V +K+FF+ LPD L+P M ++ I D + + +
Sbjct: 1305 --LDLAEKDFT---VNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKE 1359
Query: 602 IIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPN 650
++ K P + + +I HL ++ + N M + L I + PT++ P+
Sbjct: 1360 VLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPD 1408
>CE23779_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 837
Score = 79.3 bits (194), Expect = 2e-14
Identities = 56/208 (26%), Positives = 100/208 (47%), Gaps = 20/208 (9%)
Query: 474 GTAKDFKT-----FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDV 528
G A D KT F L +++D D VP ++ + + I+ L +EG+YRKS ++ V
Sbjct: 484 GKAIDPKTNGGRFFGASLVSIVD-DDHTVPTLLDRLFFAIETRALFVEGVYRKSGSLPQV 542
Query: 529 SRLKSEIDK--DPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTC 586
++ I+ D +V N D ++++ +L+K FF L + ++ ++ E
Sbjct: 543 RSIRKVIESTADADSV-------NLEDIGVHVLTTLVKAFFRELAEPIIIFDLYENFLNV 595
Query: 587 LSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTI 646
+ED R + +I LP + L++HL R+ + E N+MG L +I+GP +
Sbjct: 596 SEVEDMGERVRCLSVMIELLPKPNRAVLDRLMYHLARVADQEAVNKMGCNNLALIFGPCV 655
Query: 647 ISPNN-----EDLNDVNYQISAMELLFD 669
+ + E LNDV Q ++ L +
Sbjct: 656 LRRQDSAHAQEQLNDVARQTGCVQTLIE 683
>YER155c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 2167
Score = 78.2 bits (191), Expect = 4e-14
Identities = 51/196 (26%), Positives = 98/196 (49%), Gaps = 13/196 (6%)
Query: 480 KTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKD- 538
K F VPLE++ + + L+P IV + + I+ GL+ G+YR ++ ++ LK+ D++
Sbjct: 1963 KIFGVPLEDVCERENTLIPTIVVKLLEEIELRGLDEVGLYRIPGSIGSINALKNAFDEEG 2022
Query: 539 -PSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEE-----IKTCLSIEDS 592
N F + + + ++ + K + LPD+L M + IK +
Sbjct: 2023 ATDNSFTLEDDRWF---EVNAIAGCFKMYLRELPDSLFSHAMVNDFTDLAIKYKAHAMVN 2079
Query: 593 TTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNE 652
K M+ ++ KLP Y T++ ++FHL ++ +H N+M L I++ + I N E
Sbjct: 2080 EEYKRMMNELLQKLPTCYYQTLKRIVFHLNKVHQHVVNNKMDASNLAIVFSMSFI--NQE 2137
Query: 653 DL-NDVNYQISAMELL 667
DL N + ++ A++ +
Sbjct: 2138 DLANSMGSRLGAVQTI 2153
>7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 1817
Score = 78.2 bits (191), Expect = 4e-14
Identities = 49/163 (30%), Positives = 86/163 (52%), Gaps = 8/163 (4%)
Query: 487 ENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMIL 546
E+LL+ QD +P ++R C I+ YG+ ++GIYR S ++ RL+ D++ V +
Sbjct: 428 EHLLNSGQD-IPMVLRSCAEFIENYGV-IDGIYRLSGITSNIQRLRRAFDEE--RVPDLG 483
Query: 547 PPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSI--EDSTTRKNYMHGIIY 604
P+ DI+ V SLLK +F LP+ L ++ + + + +++ R M +
Sbjct: 484 NPE--MKQDIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAIQVKADEADERLRLMKETVL 541
Query: 605 KLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTII 647
KLP Y T++ L HL ++ +H + M K L I+W P ++
Sbjct: 542 KLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLL 584
>Hs20536040 [T] KOG4270 GTPase-activator protein
Length = 364
Score = 76.3 bits (186), Expect = 1e-13
Identities = 56/235 (23%), Positives = 107/235 (44%), Gaps = 14/235 (5%)
Query: 451 SVATTETMTRPPSTVQTIGSLPPGTAKDF---KTFAVPLENL--LDYDQDLVPAIVRQCI 505
S ++ R ++ I ++P KDF K F V L+ L ++ +PA+V +
Sbjct: 17 SFKQSKAAVRLKEDMKKIVAVPLNEQKDFTYQKLFGVSLQELERQGLTENGIPAVVWNIV 76
Query: 506 YVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKT 565
+ ++GL EG++R + NV V +L+ + + +P + D D+ SLLK
Sbjct: 77 EYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESG-------VPVELGKDGDVCSAASLLKL 129
Query: 566 FFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRIL 625
F LPD+L+ + + +++ + +I +LPD Y ++ L L ++
Sbjct: 130 FLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTKVA 189
Query: 626 EHETKNRMGLKALCIIWGPTI--ISPNNEDLNDVNYQISAMELLFDVADQAFEPE 678
+H +NRM + L ++GP + P E + + + M + + + FE E
Sbjct: 190 KHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVE 244
>7293122 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating
proteins
Length = 903
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/181 (27%), Positives = 91/181 (50%), Gaps = 7/181 (3%)
Query: 501 VRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSE--IDKDPSNVFMILPPKNYTDSDIYL 558
+R+CI V++ GL EGIYRKS +S+L + K+ +VF+ ++ +S+
Sbjct: 349 IRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDKYRDLMESNT-- 406
Query: 559 VGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALI 618
+ S LK + NL + L+ + + E R N +H ++YKLP + + +I
Sbjct: 407 IASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQMLDMVI 466
Query: 619 FHLKRILEHETKNRMGLKALCIIWGPTIISPNNED---LNDVNYQISAMELLFDVADQAF 675
HL + KN+M + L +++GPT++ P E + D+ + + +L D ++ F
Sbjct: 467 CHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIF 526
Query: 676 E 676
+
Sbjct: 527 K 527
>Hs4502221 [T] KOG4271 Rho-GTPase activating protein
Length = 1499
Score = 75.9 bits (185), Expect = 2e-13
Identities = 50/180 (27%), Positives = 89/180 (48%), Gaps = 9/180 (5%)
Query: 473 PGTAKDFKT--FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
P T +++++ F +PL++L+ ++ +P V +C+ I+ GL E +YR S N D
Sbjct: 1246 PPTRRNWESNYFGMPLQDLVTAEKP-IPLFVEKCVEFIEDTGLCTERLYRVSGNKTDQEN 1304
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
++ + +D N+ ++ + + V LK FFA+LPD L+P + E+ I
Sbjct: 1305 IQKQFVQD-HNINLVS-----MEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIP 1358
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPN 650
D T R + + I+ K Y R +I HL R+ + N M L I +G ++ P+
Sbjct: 1359 DKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFGQPLMRPD 1418
>Hs22045949 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 1444
Score = 75.9 bits (185), Expect = 2e-13
Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 14/203 (6%)
Query: 482 FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSN 541
F L L+ VP +++ C I+ +G+ ++GIYR S ++ RL+ E D
Sbjct: 19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCP 77
Query: 542 VFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHG 601
+ DI+ VGSL K +F LP+ LL E+ E+ +S + +
Sbjct: 78 DLT----REVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQN 133
Query: 602 IIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDVN--- 658
+I +LP Y T+ LI HL I +K M + L ++W P ++ + N
Sbjct: 134 VIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDA 193
Query: 659 ------YQISAMELLFDVADQAF 675
Q +E + + DQ F
Sbjct: 194 AFLAVRVQQVVIEFILNHVDQIF 216
>7295587 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 2110
Score = 74.7 bits (182), Expect = 4e-13
Identities = 62/206 (30%), Positives = 91/206 (44%), Gaps = 8/206 (3%)
Query: 476 AKDFKTFAVPLENL-LDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSE 534
AK + VPL + + VP +V C +++ GL + GIYR N +S L
Sbjct: 1191 AKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSEL 1250
Query: 535 IDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTT 594
++ + D+ +V SLLK F +LPD L+P +
Sbjct: 1251 VNTKDFQFESCASDDRW--EDVNVVSSLLKLFIRSLPDALMPASYYINFIEA-DKKFGLE 1307
Query: 595 RKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDL 654
R + I+ LP Y T++ LI HL R+ + NRM K L II+GP+II N+ L
Sbjct: 1308 RIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTL 1367
Query: 655 ----NDVNYQISAMELLFDVADQAFE 676
D+ +Q +ELL D FE
Sbjct: 1368 ETAVKDMKHQCRIVELLVTQYDYFFE 1393
>SPAC26A3.09 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1275
Score = 74.3 bits (181), Expect = 6e-13
Identities = 49/205 (23%), Positives = 96/205 (45%), Gaps = 10/205 (4%)
Query: 452 VATTETMTRPPSTVQTIGSLPPGTAKDFKTFAVPLENLLD----YDQDLVPAIVRQCIYV 507
V T M P ST L + F +PL ++ ++ +P +V +CI
Sbjct: 1034 VIETNVMLSPSSTTSA-EPLQKHIVRKSGIFGLPLNEAVNISTQFNDSGLPIVVYRCIEY 1092
Query: 508 IDKYGLNLE-GIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTF 566
++ E GIYR S + + LK + ++ + + + D++++ LLK +
Sbjct: 1093 LESCRAEKEEGIYRLSGSASTIKHLKEQFNEGVDYDLL----SSDEEFDVHVIAGLLKLY 1148
Query: 567 FANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILE 626
NLP LL M + + ++ + + + +I KLP + + +L+ HL+RI+
Sbjct: 1149 LRNLPTNLLDTSMHKLFELLPNVPNDSAALGELCDVISKLPPENFALLDSLLHHLRRIIA 1208
Query: 627 HETKNRMGLKALCIIWGPTIISPNN 651
E N+M ++ +CI++ PT+ P++
Sbjct: 1209 FEKVNKMNIRNVCIVFSPTLNIPSD 1233
>Hs7662208 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating
proteins
Length = 814
Score = 73.9 bits (180), Expect = 7e-13
Identities = 43/188 (22%), Positives = 96/188 (50%), Gaps = 21/188 (11%)
Query: 499 AIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSD--- 555
+I+R+CI+ ++ G+N +G+YR + + S + K S +++ PK ++++
Sbjct: 391 SIIRKCIHAVETRGINEQGLYR-------IVGVNSRVQKLLS---VLMDPKTASETETDI 440
Query: 556 -----IYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQ 610
I + S LKT+ LP L+ + +E+ +R + +H ++++LP+
Sbjct: 441 CAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKN 500
Query: 611 YWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED---LNDVNYQISAMELL 667
++ L+ HL + + +N M + L +++GPT++ P E + D+ +Q +E+L
Sbjct: 501 RQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEIL 560
Query: 668 FDVADQAF 675
+ ++ F
Sbjct: 561 IENHEKIF 568
>Hs21264597 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1205
Score = 73.6 bits (179), Expect = 1e-12
Identities = 47/157 (29%), Positives = 73/157 (45%), Gaps = 5/157 (3%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
+P IV +C+ I + GL EGIYRK RL + +D +V + ++ D
Sbjct: 725 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD--- 781
Query: 557 YLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRA 616
V S LK F +LPD L R IED + + ++ +LP T++A
Sbjct: 782 --VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKA 839
Query: 617 LIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED 653
LI HL + N+M + L I++GPT+ + +D
Sbjct: 840 LISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 876
>Hs16975484 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1210
Score = 73.6 bits (179), Expect = 1e-12
Identities = 47/157 (29%), Positives = 73/157 (45%), Gaps = 5/157 (3%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
+P IV +C+ I + GL EGIYRK RL + +D +V + ++ D
Sbjct: 730 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD--- 786
Query: 557 YLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRA 616
V S LK F +LPD L R IED + + ++ +LP T++A
Sbjct: 787 --VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKA 844
Query: 617 LIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED 653
LI HL + N+M + L I++GPT+ + +D
Sbjct: 845 LISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 881
>Hs16163690 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 1022
Score = 73.6 bits (179), Expect = 1e-12
Identities = 45/172 (26%), Positives = 89/172 (51%), Gaps = 6/172 (3%)
Query: 496 LVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSD 555
++P IV CI I+ YGL +GI+R S + ++V+ +K+ ++ + + + ++ D
Sbjct: 455 VIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPL-----ADDQSNHD 509
Query: 556 IYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIR 615
I V +LK +F L + L P+E ++ +C+ I++ R ++ ++ LP +R
Sbjct: 510 INSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMR 569
Query: 616 ALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDVNYQISAMELL 667
L L + ++ +N M L I +GPT++ P E + V+ Q E++
Sbjct: 570 YLFAFLNHLSQYSDENMMDPYNLAICFGPTLM-PVPEIQDQVSCQAHVNEII 620
>Hs4505507 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating
proteins
Length = 802
Score = 73.2 bits (178), Expect = 1e-12
Identities = 45/174 (25%), Positives = 88/174 (49%), Gaps = 10/174 (5%)
Query: 501 VRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEI--DKDPSNVFMILPPKNYTDSDIYL 558
VR+CI +I+ G+ EG+YR + + V +L + K P +V + +D DI
Sbjct: 390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDF-----HNSDWDIKT 444
Query: 559 VGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALI 618
+ S LK + NL + ++ + +E+ + ++ R +H ++YKLP+ + LI
Sbjct: 445 ITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLI 504
Query: 619 FHLKRILEHETKNRMGLKALCIIWGPTIISPNNED---LNDVNYQISAMELLFD 669
HL + EH +N M + +I+GPT++ + + ++ +Q +E+L +
Sbjct: 505 RHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIE 558
>7293306 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1510
Score = 72.8 bits (177), Expect = 2e-12
Identities = 50/173 (28%), Positives = 90/173 (51%), Gaps = 9/173 (5%)
Query: 482 FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSN 541
F++ + L YD VP IV +CI + +G EGIYRKS + + +L S D N
Sbjct: 1055 FSLGDQQLTRYD---VPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFN 1111
Query: 542 VFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHG 601
V + Y + D V ++LK F +LP+ LL + +T+ + ++ +
Sbjct: 1112 VE--ITRNEYNEHD---VANVLKRFMRDLPERLLGK-LTDSFVFVTELAVASEKIPIYRE 1165
Query: 602 IIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDL 654
++ +L + T+R ++ HL I + KN+M ++ L +IWGPT+++ +++L
Sbjct: 1166 LLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDEL 1218
>SPBC28E12.03_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 804
Score = 71.6 bits (174), Expect = 4e-12
Identities = 48/192 (25%), Positives = 90/192 (46%), Gaps = 15/192 (7%)
Query: 491 DYDQDL-----VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMI 545
D+DQ+ VP ++ CI I+ YG++ EG+YRKS + ++ + + + + +
Sbjct: 620 DFDQNRLTLLRVPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDT----V 675
Query: 546 LPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYK 605
L P DI V S+ K + NLP+ ++ + T + + + +I
Sbjct: 676 LDP----SEDISAVTSVFKQYLRNLPNPIITYDQYFPFITAANCASFQDKLDGFIMVIKS 731
Query: 606 LPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTII--SPNNEDLNDVNYQISA 663
LP ++ +I HL R+ + NRM K L +++ PT+I N+ D+ D+ + +
Sbjct: 732 LPPAHAEILQLIIRHLARVAAYSHANRMTSKNLAVVFSPTLIRDPDNSRDVIDMTVKNYS 791
Query: 664 MELLFDVADQAF 675
+ L D + F
Sbjct: 792 LAFLIDHVHEVF 803
>Hs4757766 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 439
Score = 70.5 bits (171), Expect = 8e-12
Identities = 47/179 (26%), Positives = 91/179 (50%), Gaps = 10/179 (5%)
Query: 471 LPPGTAKDFKTFAVPLENLLDY--DQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDV 528
+PP + F V L++L + +Q+ +P ++R+ + + + L EGI+R+SAN V
Sbjct: 231 MPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVV 290
Query: 529 SRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLS 588
++ + + M LP ++++L +LKTF LP+ LL ++ + L+
Sbjct: 291 REVQQKYN-------MGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLN 343
Query: 589 IEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTII 647
I++S R ++ LP+ Y +R L L +I H +N+M L +++GP ++
Sbjct: 344 IDES-QRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLL 401
>Hs7656904 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 464
Score = 69.7 bits (169), Expect = 1e-11
Identities = 55/197 (27%), Positives = 92/197 (45%), Gaps = 16/197 (8%)
Query: 456 ETMTRPPSTVQTIGSLPPGTAKDFKTFAVPLENLLDYDQ-DLVPAIVRQCIYVIDKYGLN 514
E T PP+ PP + F V L+ L D +Q +L+P ++R + + + GL
Sbjct: 203 EGRTPPPTKTP-----PPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLR 257
Query: 515 LEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTD-SDIYLVGSLLKTFFANLPDT 573
EG++R+SA+V V ++ ++ P N+ D DI++ +LKTF LP
Sbjct: 258 TEGLFRRSASVQTVREIQRLYNQG--------KPVNFDDYGDIHIPAVILKTFLRELPQP 309
Query: 574 LLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRM 633
LL + E+I +E S+ R I+ LP+ Y +R L+ L + N+M
Sbjct: 310 LLTFQAYEQILGITCVE-SSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKM 368
Query: 634 GLKALCIIWGPTIISPN 650
L ++G +I P+
Sbjct: 369 NSSNLACVFGLNLIWPS 385
>CE28644 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating
proteins
Length = 910
Score = 69.7 bits (169), Expect = 1e-11
Identities = 43/180 (23%), Positives = 93/180 (50%), Gaps = 5/180 (2%)
Query: 501 VRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKS-EIDKDPSNVFMILPPKNYTDSDIYLV 559
V+QCI ++++ G++ +G+YR V ++ +D+ ++ L ++ + + +
Sbjct: 413 VQQCIDILEESGIHEQGVYRNCGVTSKVQKMMMLGLDRRKASEKGGLNLRD-DEWETKTI 471
Query: 560 GSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIF 619
S +KTF NLP+ L+ E+ + D+T R +++H +++LP + ++
Sbjct: 472 SSAVKTFLRNLPEPLMTFELHNVFINAAKMGDATMRIDHIHFYVHQLPAQHLRMLEIVVR 531
Query: 620 HLKRILEHETKNRMGLKALCIIWGPTIISPNNED---LNDVNYQISAMELLFDVADQAFE 676
HLKR+ + +N M + L + +GPT++ P E + D+ + +E+L D+ F+
Sbjct: 532 HLKRVADLSNENLMTVSNLGVCFGPTLLRPKEETVAAIMDIKFCNVVVEVLISNYDKIFK 591
>CE09612 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1003
Score = 69.7 bits (169), Expect = 1e-11
Identities = 51/198 (25%), Positives = 87/198 (43%), Gaps = 9/198 (4%)
Query: 483 AVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNV 542
A LENL D +P IV +CI + YG+ EGIYR++ V + + +++ +DP
Sbjct: 572 ATRLENLR-LTGDNIPVIVDKCIRFVSAYGMKCEGIYRRNGKVTEAKTILTKLTEDPVGY 630
Query: 543 FMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGI 602
+ P + D +Y V +L+ FF L L P ++ + S +
Sbjct: 631 Y----PVHENDETVYAVADVLRQFFRKLDAPLFPSSSQADLFDLATESQSDELCARYAQL 686
Query: 603 IYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED----LNDVN 658
I T++ LI HLK + EH +NR ++ L ++ ++ + D N
Sbjct: 687 INTFELVHRSTLKKLIGHLKNVSEHAQENRASVENLAKVFAASLFLTDAMDEKVFSESYN 746
Query: 659 YQISAMELLFDVADQAFE 676
+QI+ + L D F+
Sbjct: 747 HQINVLIHLTTGYDVVFQ 764
>CE16059 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 718
Score = 69.3 bits (168), Expect = 2e-11
Identities = 47/169 (27%), Positives = 78/169 (45%), Gaps = 7/169 (4%)
Query: 482 FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSN 541
F + L +L VP IV +C I+ G+ + GIYR+ ++ RL+++ D
Sbjct: 237 FGLELTDLYMRTGKKVPVIVEKCCASIEDQGI-VTGIYRQCGIQSNIQRLRAKFDSGAEP 295
Query: 542 VFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRK-NYMH 600
+ DIY V SLLK +F LP+ L + ++ EDS + K +
Sbjct: 296 DL-----HEFGQRDIYSVSSLLKQYFRQLPNPLFTYQAYPKLIEAFEKEDSLSEKVESLR 350
Query: 601 GIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISP 649
+ +P+ Y T + L+ HL R+ + ++ M K L I+W P + P
Sbjct: 351 FSLETMPEAHYRTAKFLMEHLTRLCKSKSLTDMTSKNLAIVWSPNLFRP 399
>Hs22040999 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 918
Score = 68.6 bits (166), Expect = 3e-11
Identities = 42/172 (24%), Positives = 85/172 (49%), Gaps = 8/172 (4%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
+P +V CI I ++GL EGI+R S + ++V+ +K+ ++ + + D D+
Sbjct: 351 IPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPL-----AGDQNDHDM 405
Query: 557 YLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRA 616
+ +LK +F L L P+++ ++ C+++++ R ++ ++ LP +R
Sbjct: 406 DSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRY 465
Query: 617 LIFHLKRILEHETKNRMGLKALCIIWGPTIIS-PNNEDLNDVNYQISAMELL 667
L L + + +N M L I +GP+++S P D V+ Q EL+
Sbjct: 466 LFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHD--QVSCQAHVNELI 515
>Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 946
Score = 67.8 bits (164), Expect = 5e-11
Identities = 48/207 (23%), Positives = 94/207 (45%), Gaps = 7/207 (3%)
Query: 473 PGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLK 532
P + + + F +E + VP +V CI I+ GL EGI+R S L VS ++
Sbjct: 496 PSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIR 555
Query: 533 SEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDS 592
++ + + T D+ V +LK +F +L L P ++ E+ +E +
Sbjct: 556 DAFERGEDPLV-----EGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEAT 610
Query: 593 TTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIIS-PNN 651
R ++ ++++LP +R L L + ++ +N M L + +GPT++ P
Sbjct: 611 AERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAG 670
Query: 652 EDLNDVNYQISAM-ELLFDVADQAFEP 677
+D + +++ + + L D+ F P
Sbjct: 671 QDPVALQGRVNQLVQTLIVQPDRVFPP 697
>Hs4758750_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 878
Score = 67.8 bits (164), Expect = 5e-11
Identities = 48/191 (25%), Positives = 95/191 (49%), Gaps = 13/191 (6%)
Query: 482 FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSN 541
F V +++L D+ VP ++ + + ++ +GL EG+YRKS L+ + DP+
Sbjct: 554 FGVCVDSLTS-DKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAA 612
Query: 542 VFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHG 601
V + +N+ I+ + +LK + LP+ L+ + + + + + ++
Sbjct: 613 VKL----ENFP---IHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYA 665
Query: 602 IIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTII-SPNNED----LND 656
++ LP+ + ++ LIFHL ++ E NRM AL II+ P ++ P+N D + D
Sbjct: 666 VLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKD 725
Query: 657 VNYQISAMELL 667
V + +E+L
Sbjct: 726 VLKITTCVEML 736
>7294614 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 476
Score = 67.0 bits (162), Expect = 9e-11
Identities = 49/197 (24%), Positives = 93/197 (46%), Gaps = 16/197 (8%)
Query: 459 TRPPSTVQTIGSLPPGTAKDFKT-----FAVPLENLLDYDQDL--VPAIVRQCIYVIDKY 511
+R PST ++ + K F VPL+ ++ L +P IVR+C+ +
Sbjct: 246 SRKPSTPPPSSNINASRQQQHKMATTHQFGVPLKFIVMNSPCLNSIPPIVRKCVDSLSIT 305
Query: 512 G-LNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANL 570
G ++ EGI+R+S N ++ LK +++ + +++++ LLK+F +L
Sbjct: 306 GVIDTEGIFRRSGNHSEIMALKERVNRGED--------VDLKSVNVHVIAGLLKSFLRDL 357
Query: 571 PDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETK 630
+ LL E+ E++ L +N I KLP+ Y + ++ L R+++ E
Sbjct: 358 AEPLLTFELYEDVTGFLDWPKEERSRNVTQLIREKLPEENYELFKYIVEFLVRVMDCEDL 417
Query: 631 NRMGLKALCIIWGPTII 647
N+M L I++GP +
Sbjct: 418 NKMTSSNLAIVFGPNFL 434
>HsM16975482 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1704
Score = 65.9 bits (159), Expect = 2e-10
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 5/162 (3%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
VP IV CI + +YGL + IY+K+ + L +S L KD + F + K+ +
Sbjct: 1128 VPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARS-FKLRAGKHQLED-- 1184
Query: 557 YLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRA 616
V ++LK+F +++ D LL +E+ + L +D R I LP T+ A
Sbjct: 1185 --VTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAA 1242
Query: 617 LIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDVN 658
+I HL R+ + N M L +++ + + +VN
Sbjct: 1243 IIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVN 1284
>Hs21264594 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 876
Score = 65.9 bits (159), Expect = 2e-10
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 5/162 (3%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
VP IV CI + +YGL + IY+K+ + L +S L KD + F + K+ +
Sbjct: 300 VPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARS-FKLRAGKHQLED-- 356
Query: 557 YLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRA 616
V ++LK+F +++ D LL +E+ + L +D R I LP T+ A
Sbjct: 357 --VTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAA 414
Query: 617 LIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDVN 658
+I HL R+ + N M L +++ + + +VN
Sbjct: 415 IIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVN 456
>Hs21264592 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1704
Score = 65.9 bits (159), Expect = 2e-10
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 5/162 (3%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
VP IV CI + +YGL + IY+K+ + L +S L KD + F + K+ +
Sbjct: 1128 VPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARS-FKLRAGKHQLED-- 1184
Query: 557 YLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRA 616
V ++LK+F +++ D LL +E+ + L +D R I LP T+ A
Sbjct: 1185 --VTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAA 1242
Query: 617 LIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDVN 658
+I HL R+ + N M L +++ + + +VN
Sbjct: 1243 IIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVN 1284
>Hs20540662 [T] KOG4271 Rho-GTPase activating protein
Length = 707
Score = 65.9 bits (159), Expect = 2e-10
Identities = 44/153 (28%), Positives = 76/153 (48%), Gaps = 9/153 (5%)
Query: 473 PGTAKDFKT--FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
P T +++++ F +PL++L+ ++ +P V +C+ I+ GL EG+YR S N D
Sbjct: 504 PPTCRNWESNYFGMPLQDLVTAEKP-IPVFVEKCVEFIEDTGLCTEGLYRVSRNETDQDN 562
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
++ + D+D N+ ++ + + V LK FFA+LP L+P + E+ I
Sbjct: 563 IQKQFDQD-HNINLV-----SMEVTVNAVAGALKAFFADLPVPLIPYSLHPELLETAKIP 616
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKR 623
D T + + I K Y R +I HL R
Sbjct: 617 DKTECLHALKEIAKKFHPVNYDVFRYMITHLNR 649
>CE18872 [R] KOG3564 GTPase-activating protein
Length = 681
Score = 65.9 bits (159), Expect = 2e-10
Identities = 51/205 (24%), Positives = 91/205 (43%), Gaps = 29/205 (14%)
Query: 450 PSVATTETMTRPPSTVQTIGSLPPGTAK----DFKTFAVPLENLLDYDQDLVPAIVRQCI 505
P + +TM P S ++ PG + DF T A P+ +PA V C+
Sbjct: 398 PCIPRPKTMMTPKSALR---GAKPGAGEFRLQDFCTSAKPM----------IPAAVIHCV 444
Query: 506 YVIDKYGLNLEGIYRKSANVLDVSRLKSEI-DKDPSNVFMILPPKNYTDSDIYLVGSLLK 564
++ GL EGIYR V V+ L E+ K NV + D+ ++ LK
Sbjct: 445 VALEARGLTQEGIYRVPGQVRTVNVLLDELRSKTVPNVGL---------HDVEVITDTLK 495
Query: 565 TFFANLPDTLLPREMTEEIKTCLSI--EDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLK 622
F +L D L+PR +E+ ++ D + ++ +I +LP T+ L H +
Sbjct: 496 RFLRDLKDPLIPRTSRQELIVAANLYSTDPDNGRLALNRVICELPQANRDTLAYLFIHWR 555
Query: 623 RILEHETKNRMGLKALCIIWGPTII 647
+++ ++N+M +A+ + P ++
Sbjct: 556 KVIAQSSRNKMNCEAMARMVAPAVM 580
>Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 710
Score = 65.5 bits (158), Expect = 3e-10
Identities = 44/176 (25%), Positives = 84/176 (47%), Gaps = 10/176 (5%)
Query: 476 AKDFKTFAVPLENLLDYDQDL-----VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
A + + F VPL++LL+ D + VP +++ + ++K GL++EGI R + V
Sbjct: 234 AAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKG 293
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
L+ ++++D ++ D+ LLK F LP LL E +I
Sbjct: 294 LEQKLERDFYAGLFSWDEVHHNDAS-----DLLKRFIRKLPTPLLTAEYLPAFAVVPNIP 348
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTI 646
+ R +H +I LP+ ++AL+ L++++ E N+M L+ + + P +
Sbjct: 349 NLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNL 404
>Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 618
Score = 65.1 bits (157), Expect = 3e-10
Identities = 50/179 (27%), Positives = 86/179 (47%), Gaps = 18/179 (10%)
Query: 477 KDFKTFAVPLENLLDYDQDLVPA-----IVRQCIYVIDKYGLNLEGIYRKSANVLDVSRL 531
KD F VPL LL+ DQ VP I ++ I I++ GL EG+ R + + L
Sbjct: 272 KDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNL 331
Query: 532 KSEID-KDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
E++ K F N+ + SLLK F LP LL E +K +++
Sbjct: 332 CQELEAKFYEGTF------NWESVKQHDAASLLKLFIRELPQPLL---SVEYLKAFQAVQ 382
Query: 591 DSTTRKNYMHG---IIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTI 646
+ T+K + ++ LPD T++AL+ L+R+++++ KN+M + + ++ P +
Sbjct: 383 NLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNL 441
>Hs13775230 [T] KOG4270 GTPase-activator protein
Length = 655
Score = 63.9 bits (154), Expect = 8e-10
Identities = 57/223 (25%), Positives = 96/223 (42%), Gaps = 24/223 (10%)
Query: 441 PNIRQTSVAPSVATTETMTRPPSTVQTIG---SLPPGTAKDFKTFAVPLENLLDYDQD-- 495
P R + P+ A T P +T + I S G F LE+ + Y++
Sbjct: 2 PEDRNSGGCPAGALASTPFIPKTTYRRIKRCFSFRKGI------FGQKLEDTVRYEKRYG 55
Query: 496 --LVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTD 553
L P +V QC+ I + GL EG++R V L+ D P ++
Sbjct: 56 NRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEK-------PSFDSN 108
Query: 554 SDIYLVGSLLKTFFANLPDTLLPREMTEEIKTC---LSIEDSTTRKNYMHGIIYKLPDGQ 610
+D++ V SLLK + LP+ ++P E+ +C LS E+ K + + LP
Sbjct: 109 TDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKE-LAKQVKSLPVVN 167
Query: 611 YWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED 653
Y ++ + L + + N+M ++ L ++GP I+ P ED
Sbjct: 168 YNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVED 210
>Hs21361397 [R] KOG3564 GTPase-activating protein
Length = 632
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/191 (26%), Positives = 87/191 (44%), Gaps = 13/191 (6%)
Query: 486 LENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMI 545
L + + ++P+IV C+ I++ GL G+YR S V LK + + +
Sbjct: 351 LADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKT----- 405
Query: 546 LPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYK 605
+P + D DI+ + SLLK F NL + LL + I D M+ + +
Sbjct: 406 VPLLSKVD-DIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGE 464
Query: 606 LPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIIS---PNNED---LNDVNY 659
LP T+ L+ HL+R+ + +M + L ++GPTI++ PN + L D+
Sbjct: 465 LPQANRDTLAFLMIHLQRVAQ-SPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKR 523
Query: 660 QISAMELLFDV 670
Q +E L +
Sbjct: 524 QPKVVERLLSL 534
>CE20680 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 1059
Score = 62.4 bits (150), Expect = 2e-09
Identities = 49/199 (24%), Positives = 87/199 (43%), Gaps = 9/199 (4%)
Query: 480 KTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDP 539
K F L+ ++ + +P +V+ I + +Y L +G++R S + +++R + ++
Sbjct: 523 KLFGGSLDEYVEATGEEIPLLVQSAIAYLSRYSLRNQGLFRVSGSQSEINRFREAYERG- 581
Query: 540 SNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYM 599
++F L SD +LK +F L + + P M E+ C E T
Sbjct: 582 EDLFQYLDD----GSDANSAAGVLKLYFRELREPIFPIFMFEQFCDCAKSESPTEFVRRA 637
Query: 600 HGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDVNY 659
++ KLP +R L L + E +N M L I +GPT++ P E + V Y
Sbjct: 638 RELVSKLPVSHVLLLRFLFAFLSHLCEFADENMMEPHNLAICFGPTLL-PIPEGKDQVFY 696
Query: 660 QISAMELLFDV---ADQAF 675
EL+ ++ AD F
Sbjct: 697 HNYVNELVRNLIIHADDVF 715
>HsM7019433 [R] KOG3564 GTPase-activating protein
Length = 632
Score = 62.0 bits (149), Expect = 3e-09
Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 13/191 (6%)
Query: 486 LENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMI 545
L + + ++P+IV C+ I++ GL G+YR S V LK + + +
Sbjct: 351 LADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKT----- 405
Query: 546 LPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYK 605
+P + D DI+ + SLLK F NL + LL + I D M+ + +
Sbjct: 406 VPLLSKVD-DIHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGE 464
Query: 606 LPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIIS---PNNEDL---NDVNY 659
LP T+ L+ HL+R+ + +M + L ++GPTI++ PN + + D+
Sbjct: 465 LPQANRDTLAFLMIHLQRVAQ-SPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMSQDIKR 523
Query: 660 QISAMELLFDV 670
Q +E L +
Sbjct: 524 QPKVVERLLSL 534
>Hs7662242 [T] KOG4270 GTPase-activator protein
Length = 818
Score = 62.0 bits (149), Expect = 3e-09
Identities = 38/172 (22%), Positives = 83/172 (48%), Gaps = 7/172 (4%)
Query: 481 TFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPS 540
+F PLE L + + C+ ++ + G+ EG++R + + + +LK+ +D
Sbjct: 252 SFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALD---- 307
Query: 541 NVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMH 600
++ + Y+ +D + + LK++ LP+ L+ E+ +E ++++ + +
Sbjct: 308 --CCVVDVQEYS-ADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALW 364
Query: 601 GIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNE 652
KLP + IR LI L ++ E++ N+M + I+ GP ++ P E
Sbjct: 365 NACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAE 416
>Hs21314774 [T] KOG4724 Predicted Rho GTPase-activating protein
Length = 731
Score = 61.6 bits (148), Expect = 4e-09
Identities = 47/190 (24%), Positives = 86/190 (44%), Gaps = 15/190 (7%)
Query: 493 DQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYT 552
D D +P ++ + ++ G + EGI+R++AN LK E++ + LP
Sbjct: 96 DSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLP----- 150
Query: 553 DSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYW 612
++L+ + K F ++P LL ++ EE L ++D R + + KLP
Sbjct: 151 ---VHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLL 207
Query: 613 TIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNN------EDLNDVNYQISAM-E 665
++ L++ L I ++ NRM L I GP +++ N E D+N ++ + E
Sbjct: 208 LLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDLNNKVKTLVE 267
Query: 666 LLFDVADQAF 675
L D + F
Sbjct: 268 FLIDNCFEIF 277
>7290597 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 494
Score = 60.8 bits (146), Expect = 6e-09
Identities = 40/183 (21%), Positives = 78/183 (41%), Gaps = 9/183 (4%)
Query: 471 LPPGTAKDFK----TFAVPLENLLDYD-QDLVPAIVRQCIYVIDKYGLNLEGIYRKSANV 525
+PP D K F L ++ + +P +VR+C+ ++ G+ EGIYR S
Sbjct: 287 VPPKCVPDLKRIRGVFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFA 346
Query: 526 LDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKT 585
++ LK +D++ M ++ ++ LK + LP L+ +
Sbjct: 347 DEIEALKLALDREGEKTDM----SETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMA 402
Query: 586 CLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPT 645
++ M + +LP + ++ ++ HLKR+ H N+M L ++ PT
Sbjct: 403 AGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPT 462
Query: 646 IIS 648
+I+
Sbjct: 463 LIA 465
>Hs20270373 [T] KOG4724 Predicted Rho GTPase-activating protein
Length = 266
Score = 60.5 bits (145), Expect = 8e-09
Identities = 40/160 (25%), Positives = 75/160 (46%), Gaps = 8/160 (5%)
Query: 493 DQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYT 552
D D +P ++ + ++ G + EGI+R++AN LK E++ + LP
Sbjct: 96 DSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLP----- 150
Query: 553 DSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYW 612
++L+ + K F ++P LL ++ EE L ++D R + + KLP
Sbjct: 151 ---VHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLL 207
Query: 613 TIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNE 652
++ L++ L I ++ NRM L I GP +++ N+
Sbjct: 208 LLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLEND 247
>7303262 [R] KOG3564 GTPase-activating protein
Length = 625
Score = 60.5 bits (145), Expect = 8e-09
Identities = 41/187 (21%), Positives = 85/187 (44%), Gaps = 8/187 (4%)
Query: 467 TIGSLPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVL 526
T+ +P KT + + ++PA++ C+ I+ GL G+YR S++
Sbjct: 364 TVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSER 423
Query: 527 DVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTC 586
+ LK + + + + ++DIY++ +K F +L + L+P ++
Sbjct: 424 EYKALKEQFLRGKATPHL-------GNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANA 476
Query: 587 LSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTI 646
+ D+ T ++ + + +LP T+ LI H +RI + M + + +I+GPTI
Sbjct: 477 VQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQCPVV-LMPIDNISLIFGPTI 535
Query: 647 ISPNNED 653
+ + D
Sbjct: 536 VGYSTPD 542
>Hs21264337_1 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1348
Score = 60.1 bits (144), Expect = 1e-08
Identities = 41/161 (25%), Positives = 72/161 (44%), Gaps = 5/161 (3%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
+P IV CI + ++GL LEG+YRK RL +E +D +V + P +++ +
Sbjct: 919 IPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSV-KLRPGEHFVED-- 975
Query: 557 YLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRA 616
V LK FF L D + + + + R +I LP T+
Sbjct: 976 --VTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLAT 1033
Query: 617 LIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDV 657
LI HL R+ + N+M + L +++ P++ + ++V
Sbjct: 1034 LIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEV 1074
>HsM19923515 [T] KOG4270 GTPase-activator protein
Length = 726
Score = 59.7 bits (143), Expect = 1e-08
Identities = 40/171 (23%), Positives = 74/171 (42%), Gaps = 7/171 (4%)
Query: 482 FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSN 541
F PL L + + C+ ++ + G+ EG++R A + +LK+ +D S+
Sbjct: 173 FGTPLAEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 232
Query: 542 VFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHG 601
+ SD + V LK++ LP+ L+ + EE S++D + +
Sbjct: 233 LDEFY-------SDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWR 285
Query: 602 IIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNE 652
KLP + R LI L ++ + N+M + I+ GP ++ NE
Sbjct: 286 TCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNE 336
>Hs7382484 [TZ] KOG2710 Rho GTPase-activating protein
Length = 765
Score = 59.7 bits (143), Expect = 1e-08
Identities = 61/264 (23%), Positives = 108/264 (40%), Gaps = 23/264 (8%)
Query: 411 STSSRPLKSMVDVVPPSETNKKDFPTLDPRPNIRQTSVAPSVATTETMTRPPSTVQTIGS 470
S+S+ L S + P+E+ + P +P P R+ + T+ ++ +
Sbjct: 328 SSSNSSLSSTSET--PNESTSPNTP--EPAPRARRRGAMSVDSITDLDDNQSRLLEALQL 383
Query: 471 LPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
P A+ K A + L+ VP +V C ++K+GL GI+R ++ V +
Sbjct: 384 SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQ 443
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
L+ E D+ + + ++ V +LLK F ++PD LL RE+ L +E
Sbjct: 444 LREEFDRG-------IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLE 496
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHE-----------TKNRMGLKALC 639
+ + +IY LP T+ L+ L + H T N+M L
Sbjct: 497 PE-EQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLA 555
Query: 640 IIWGPTIISPNNEDLNDVNYQISA 663
I+GP ++ + + Q SA
Sbjct: 556 TIFGPNLLHKQKSSDKEFSVQSSA 579
>Hs7382482 [TZ] KOG2710 Rho GTPase-activating protein
Length = 974
Score = 59.7 bits (143), Expect = 1e-08
Identities = 61/264 (23%), Positives = 108/264 (40%), Gaps = 23/264 (8%)
Query: 411 STSSRPLKSMVDVVPPSETNKKDFPTLDPRPNIRQTSVAPSVATTETMTRPPSTVQTIGS 470
S+S+ L S + P+E+ + P +P P R+ + T+ ++ +
Sbjct: 328 SSSNSSLSSTSET--PNESTSPNTP--EPAPRARRRGAMSVDSITDLDDNQSRLLEALQL 383
Query: 471 LPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
P A+ K A + L+ VP +V C ++K+GL GI+R ++ V +
Sbjct: 384 SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQ 443
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
L+ E D+ + + ++ V +LLK F ++PD LL RE+ L +E
Sbjct: 444 LREEFDRG-------IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLE 496
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHE-----------TKNRMGLKALC 639
+ + +IY LP T+ L+ L + H T N+M L
Sbjct: 497 PE-EQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLA 555
Query: 640 IIWGPTIISPNNEDLNDVNYQISA 663
I+GP ++ + + Q SA
Sbjct: 556 TIFGPNLLHKQKSSDKEFSVQSSA 579
>Hs7382480 [TZ] KOG2710 Rho GTPase-activating protein
Length = 771
Score = 59.7 bits (143), Expect = 1e-08
Identities = 61/264 (23%), Positives = 108/264 (40%), Gaps = 23/264 (8%)
Query: 411 STSSRPLKSMVDVVPPSETNKKDFPTLDPRPNIRQTSVAPSVATTETMTRPPSTVQTIGS 470
S+S+ L S + P+E+ + P +P P R+ + T+ ++ +
Sbjct: 125 SSSNSSLSSTSET--PNESTSPNTP--EPAPRARRRGAMSVDSITDLDDNQSRLLEALQL 180
Query: 471 LPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
P A+ K A + L+ VP +V C ++K+GL GI+R ++ V +
Sbjct: 181 SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQ 240
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
L+ E D+ + + ++ V +LLK F ++PD LL RE+ L +E
Sbjct: 241 LREEFDRG-------IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLE 293
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHE-----------TKNRMGLKALC 639
+ + +IY LP T+ L+ L + H T N+M L
Sbjct: 294 PE-EQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLA 352
Query: 640 IIWGPTIISPNNEDLNDVNYQISA 663
I+GP ++ + + Q SA
Sbjct: 353 TIFGPNLLHKQKSSDKEFSVQSSA 376
>Hs7382478 [TZ] KOG2710 Rho GTPase-activating protein
Length = 562
Score = 59.7 bits (143), Expect = 1e-08
Identities = 61/264 (23%), Positives = 108/264 (40%), Gaps = 23/264 (8%)
Query: 411 STSSRPLKSMVDVVPPSETNKKDFPTLDPRPNIRQTSVAPSVATTETMTRPPSTVQTIGS 470
S+S+ L S + P+E+ + P +P P R+ + T+ ++ +
Sbjct: 125 SSSNSSLSSTSET--PNESTSPNTP--EPAPRARRRGAMSVDSITDLDDNQSRLLEALQL 180
Query: 471 LPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
P A+ K A + L+ VP +V C ++K+GL GI+R ++ V +
Sbjct: 181 SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQ 240
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
L+ E D+ + + ++ V +LLK F ++PD LL RE+ L +E
Sbjct: 241 LREEFDRG-------IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLE 293
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHE-----------TKNRMGLKALC 639
+ + +IY LP T+ L+ L + H T N+M L
Sbjct: 294 PE-EQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLA 352
Query: 640 IIWGPTIISPNNEDLNDVNYQISA 663
I+GP ++ + + Q SA
Sbjct: 353 TIFGPNLLHKQKSSDKEFSVQSSA 376
>Hs4758882 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1261
Score = 59.7 bits (143), Expect = 1e-08
Identities = 50/215 (23%), Positives = 95/215 (43%), Gaps = 38/215 (17%)
Query: 493 DQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYT 552
+ D +P I++ C I+ L L+GIYR N + +L ++ N ++ ++
Sbjct: 680 EPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCLALE----NGMHLVDISEFS 735
Query: 553 DSDIYLVGSLLKTFFANLPDTL----LPREMTEEIKTCLSI-EDSTTRKNYMHG------ 601
DI +LK + LP+ L +E + K + E+ T+KN +
Sbjct: 736 SHDIC---DVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNM 792
Query: 602 -------------IIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIIS 648
++ +LP + ++ LI HLKR+++H +N+M K L +I+GP++I
Sbjct: 793 CIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIR 852
Query: 649 PNNE-------DLNDVNYQISAMELLFDVADQAFE 676
P + L + + Q +E L + + F+
Sbjct: 853 PRPQTAPITISSLAEYSNQARLVEFLITYSQKIFD 887
>Hs4502223 [TZ] KOG2710 Rho GTPase-activating protein
Length = 480
Score = 59.7 bits (143), Expect = 1e-08
Identities = 61/264 (23%), Positives = 108/264 (40%), Gaps = 23/264 (8%)
Query: 411 STSSRPLKSMVDVVPPSETNKKDFPTLDPRPNIRQTSVAPSVATTETMTRPPSTVQTIGS 470
S+S+ L S + P+E+ + P +P P R+ + T+ ++ +
Sbjct: 150 SSSNSSLSSTSET--PNESTSPNTP--EPAPRARRRGAMSVDSITDLDDNQSRLLEALQL 205
Query: 471 LPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
P A+ K A + L+ VP +V C ++K+GL GI+R ++ V +
Sbjct: 206 SLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQ 265
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
L+ E D+ + + ++ V +LLK F ++PD LL RE+ L +E
Sbjct: 266 LREEFDRG-------IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLE 318
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHE-----------TKNRMGLKALC 639
+ + +IY LP T+ L+ L + H T N+M L
Sbjct: 319 PE-EQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLA 377
Query: 640 IIWGPTIISPNNEDLNDVNYQISA 663
I+GP ++ + + Q SA
Sbjct: 378 TIFGPNLLHKQKSSDKEFSVQSSA 401
>Hs21361736 [T] KOG4270 GTPase-activator protein
Length = 803
Score = 59.7 bits (143), Expect = 1e-08
Identities = 40/171 (23%), Positives = 74/171 (42%), Gaps = 7/171 (4%)
Query: 482 FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSN 541
F PLE L + + C+ ++ + G+ EG++R A + +LK+ +D S+
Sbjct: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
Query: 542 VFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHG 601
+ SD + V LK++ LP+ L+ + EE S++D + +
Sbjct: 310 LDEFY-------SDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWR 362
Query: 602 IIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNE 652
KLP + R LI L ++ + N+M + I+ P ++ NE
Sbjct: 363 TCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLAPNLLWARNE 413
>Hs15147252 [T] KOG4270 GTPase-activator protein
Length = 621
Score = 59.3 bits (142), Expect = 2e-08
Identities = 41/183 (22%), Positives = 82/183 (44%), Gaps = 8/183 (4%)
Query: 472 PPGTAKDF-KTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSR 530
P TA F + + V L L + + C+ ++ G+ EG++R +A + R
Sbjct: 183 PSMTATHFPRVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKR 242
Query: 531 LKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIE 590
LK + DP ++ SD + V LK++ LP+ L+ ++ ++ S++
Sbjct: 243 LKQTMASDPHSLEEFC-------SDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLK 295
Query: 591 DSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPN 650
+ R + + +LP +R L+ L R+ E + N+M + I+ GP ++ P
Sbjct: 296 EPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPP 355
Query: 651 NED 653
++
Sbjct: 356 EKE 358
>CE06642 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 634
Score = 58.9 bits (141), Expect = 2e-08
Identities = 48/203 (23%), Positives = 87/203 (42%), Gaps = 16/203 (7%)
Query: 462 PSTVQTIGSLPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRK 521
P Q G + F VPL+ LL++ +P I+ + I + + GL +GIYR
Sbjct: 157 PRIQQVCGQAAKLVDRRTSIFGVPLKGLLEHQNRHIPLIIEKSIDQLQRRGLRAKGIYRT 216
Query: 522 SANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTE 581
+ + + ++ S+ + L +N + + S++K + LP+ LL E+ +
Sbjct: 217 CGVKSKIEEICNAFERSSSDDEVCLDNENPMN-----LASVVKLYLRKLPEPLLTFELYD 271
Query: 582 EI----KTCLSIEDSTT-----RKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNR 632
+ C S + S + R + + KLP Y T++ ++ HL R+ N
Sbjct: 272 DFVRLGTECCSAQASGSNCEEERVEQLRQLARKLPVHNYETLKFIMLHLNRVSWFHEVNL 331
Query: 633 MGLKALCIIWGPTII--SPNNED 653
M L + P++I SP D
Sbjct: 332 MSTSNLSTVIAPSLIWMSPKRID 354
>CE06641 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 863
Score = 58.9 bits (141), Expect = 2e-08
Identities = 48/203 (23%), Positives = 87/203 (42%), Gaps = 16/203 (7%)
Query: 462 PSTVQTIGSLPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRK 521
P Q G + F VPL+ LL++ +P I+ + I + + GL +GIYR
Sbjct: 386 PRIQQVCGQAAKLVDRRTSIFGVPLKGLLEHQNRHIPLIIEKSIDQLQRRGLRAKGIYRT 445
Query: 522 SANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTE 581
+ + + ++ S+ + L +N + + S++K + LP+ LL E+ +
Sbjct: 446 CGVKSKIEEICNAFERSSSDDEVCLDNENPMN-----LASVVKLYLRKLPEPLLTFELYD 500
Query: 582 EI----KTCLSIEDSTT-----RKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNR 632
+ C S + S + R + + KLP Y T++ ++ HL R+ N
Sbjct: 501 DFVRLGTECCSAQASGSNCEEERVEQLRQLARKLPVHNYETLKFIMLHLNRVSWFHEVNL 560
Query: 633 MGLKALCIIWGPTII--SPNNED 653
M L + P++I SP D
Sbjct: 561 MSTSNLSTVIAPSLIWMSPKRID 583
>7302107 [T] KOG1452 Predicted Rho GTPase-activating protein
Length = 1844
Score = 58.5 bits (140), Expect = 3e-08
Identities = 38/154 (24%), Positives = 75/154 (48%), Gaps = 7/154 (4%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
VP ++R+C+ +++ GL++ G+YR + L+ +++ V L P++ D I
Sbjct: 942 VPIVLRRCVEEVERRGLDIIGLYRLCGSATKKRLLREAFERNSRAVE--LTPEHVPD--I 997
Query: 557 YLVGSLLKTFFANLPDTLLPR---EMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWT 613
++ +LK + LP+ L R +MT + +D M I+ LP T
Sbjct: 998 NVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPDDPEGNAKLMLSILDCLPRANRAT 1057
Query: 614 IRALIFHLKRILEHETKNRMGLKALCIIWGPTII 647
+ L+ HL ++ + +N+M +AL + GP ++
Sbjct: 1058 LVFLLDHLSLVVSNSERNKMSAQALATVMGPPLM 1091
>7293370 [T] KOG4271 Rho-GTPase activating protein
Length = 553
Score = 58.2 bits (139), Expect = 4e-08
Identities = 42/179 (23%), Positives = 81/179 (44%), Gaps = 19/179 (10%)
Query: 489 LLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPP 548
++ +Q +P + +C+ I+K GL+ EGIYR + V L ++D + L
Sbjct: 347 MITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDAL-- 404
Query: 549 KNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIK----------TCLSIE---DSTTR 595
D + V + LK FF+ L +++ +E++ + L++E D + R
Sbjct: 405 ----DIPVNAVATALKDFFSKRLPPLFSKDIIKELEEIAGSRGVGNSKLNVEVKTDRSCR 460
Query: 596 KNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDL 654
+ ++ KLP + ++ + H + ++ N M K L I W PT+I + D+
Sbjct: 461 LIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDM 519
>YDR379w_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 868
Score = 57.8 bits (138), Expect = 5e-08
Identities = 47/181 (25%), Positives = 84/181 (45%), Gaps = 25/181 (13%)
Query: 492 YDQDLVPAIVRQCIYVIDK--YGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPK 549
Y++ VP I+R CI I+K GLN+EG+YRKS + V +++E ++ S L PK
Sbjct: 655 YEKSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLSPK 714
Query: 550 --NYTDSDIYLVGSLLKTFFANLPDTLLP-------------REMTEEIKTCLSIEDSTT 594
+ DI+ V S+LK + LPD +L ++ E + +
Sbjct: 715 LNALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSP 774
Query: 595 RKNYMHGIIYK--------LPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTI 646
+K ++ ++ K LP ++ L H+ ++ +N M L L +++ P++
Sbjct: 775 QKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSL 834
Query: 647 I 647
I
Sbjct: 835 I 835
>Hs7706107 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 970
Score = 57.4 bits (137), Expect = 7e-08
Identities = 42/165 (25%), Positives = 77/165 (46%), Gaps = 19/165 (11%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
VP +V +C I+ L+++GIYR S + + V RL + + V + + +
Sbjct: 564 VPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVEL-------SGNSP 616
Query: 557 YLVGSLLKTFFANLPDTLLPREMTEEIKTCLSI------EDSTTRK------NYMHGIIY 604
+ V S+LK F L + ++P + + + +D T + ++
Sbjct: 617 HDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPDVIRSLKTLLV 676
Query: 605 KLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISP 649
+LPD Y T+R L+ HL R+ +N+M L I++GPT++ P
Sbjct: 677 QLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRP 721
Score = 50.4 bits (119), Expect = 9e-06
Identities = 58/257 (22%), Positives = 110/257 (42%), Gaps = 14/257 (5%)
Query: 4 DTSESGTDPNLTGCVAEPSQSNDL-LQREEVK-KVLSSDIAINALLSRLKGSLLTCEEFT 61
D + + T N C + PS + L EE+ +++ + ++A L K +E
Sbjct: 53 DKTPTATVTNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTWSRYAKELL 112
Query: 62 KFMRKKYLYEEEHAQEMSKTT---KHFFQETGNSGLSRSIHQLLEYDNKLSQVKISYVRA 118
+ K+ YE E A+ K K Q+ + L LE+D L + + V
Sbjct: 113 AWTEKRASYELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGTLAMETVAQ 172
Query: 119 LQKIYDEVTALLLT-VTKTRKSLKEKSRRLEKDVSDAIHTAEKAKSRYISLCQDWEKLRL 177
++ Y + A T + K RK KE+ + +K +++A+ +A+ +Y+ +D + R
Sbjct: 173 QKRDYYQPLAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQRSEDL-RARS 231
Query: 178 TDPTKTKLTLRGSKTTKEQE------EDLQRKIDSADLEYKQRVDHSNSLRNTFLSKERP 231
+ +K+QE E+ Q K A+ Y+ V +N+ R L +
Sbjct: 232 QGSPEDSAPQASPGPSKQQERRRRSREEAQAKAQEAEALYQACVREANA-RQQDLEIAKQ 290
Query: 232 QIVSELKDLILEIDTAM 248
+IVS ++ L+ + D +
Sbjct: 291 RIVSHVRKLVFQGDEVL 307
>7300563 [T] KOG4270 GTPase-activator protein
Length = 740
Score = 56.6 bits (135), Expect = 1e-07
Identities = 43/176 (24%), Positives = 74/176 (41%), Gaps = 7/176 (3%)
Query: 474 GTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKS 533
GT K F L+ L + IV C + ++GL EG+ R + R+K
Sbjct: 243 GTEKS--RFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKH 300
Query: 534 EIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDST 593
++ + P +Y D +++GS+LK + LP+ LL + ++
Sbjct: 301 ALEAQHVKTPL---PLDYQDP--HVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEA 355
Query: 594 TRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISP 649
RK + I+ KLP Y +R L L + + N+M + L I+ P ++ P
Sbjct: 356 ERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWP 411
>Hs13491176 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 383
Score = 56.2 bits (134), Expect = 2e-07
Identities = 45/179 (25%), Positives = 82/179 (45%), Gaps = 17/179 (9%)
Query: 477 KDFKTFAVPLENLLDYDQDL-----VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRL 531
+D F VPL LLD D+ VP ++++ +++ GL EGI+R S V +
Sbjct: 34 RDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQY 93
Query: 532 KSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIED 591
+ E+D + + ++ + +LK FF LP +L P E I +S+ +
Sbjct: 94 REELDAKFNADKFKWDKMCHREAAV-----MLKAFFRELPTSLFP---VEYIPAFISLME 145
Query: 592 S----TTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTI 646
+ +H ++ LPD +AL+ +++ +E+KNRM L + + P +
Sbjct: 146 RGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNL 204
>YOR127w_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 884
Score = 56.2 bits (134), Expect = 2e-07
Identities = 45/182 (24%), Positives = 82/182 (44%), Gaps = 28/182 (15%)
Query: 491 DYDQDLVPAIVRQCIYVI--DKYGLNLEGIYRKSANVLDVSRLKSEID--KDPSNVFMIL 546
+Y+ + +P I+ CI I D+ + EGIYRKS + L + ++ + K N
Sbjct: 675 NYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEEIEKQFSAWKVQQNTET-- 732
Query: 547 PPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEI------------------KTCLS 588
P T+ D+ +V +LK + LP+ + ++ E + K L
Sbjct: 733 -PNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMENLPFVGGKLSLE 791
Query: 589 IEDSTT---RKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPT 645
++S T K+ + I+ LP Y +R L H++++ + NRM L L +++ P
Sbjct: 792 AKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTLYNLALVFAPG 851
Query: 646 II 647
+I
Sbjct: 852 LI 853
>Hs22065906 [T] KOG4724 Predicted Rho GTPase-activating protein
Length = 975
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/168 (23%), Positives = 83/168 (48%), Gaps = 10/168 (5%)
Query: 482 FAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSN 541
F + L N+ + D +P V ++ +++ G +GI+R+SANV LK +++ S
Sbjct: 147 FGISLPNICENDN--LPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLN---SG 201
Query: 542 VFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHG 601
V + L ++ I+++ S+LK F N+P ++ ++ + + + + + N +
Sbjct: 202 VEVHLDCES-----IFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQR 256
Query: 602 IIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISP 649
++ +LP +R L L I +H + N+M L + P+I+ P
Sbjct: 257 LLDQLPRANVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWP 304
>SPBC3F6.05_2 [TZ] KOG2710 Rho GTPase-activating protein
Length = 292
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/179 (22%), Positives = 80/179 (44%), Gaps = 13/179 (7%)
Query: 497 VPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDI 556
+PA + + + + +++ G++RK+ N+ + L +D P ++ +Y
Sbjct: 3 IPAFIGNTLAAMKRKDMSVVGVFRKNGNIRRLKELSDMLDVSPDSI-------DYEQETP 55
Query: 557 YLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRA 616
+ +LLK F LPD LL ++ T +E R +H I LP G T+
Sbjct: 56 IQLAALLKKFLRELPDPLLTFKLFGLFITSSKLESEEERMRVLHLTICLLPKGHRDTMEV 115
Query: 617 LIFHLKRI-----LEHETKNRMGLKALCIIWGPTII-SPNNEDLNDVNYQISAMELLFD 669
+ L + ++ E ++M + L + P I+ S +N+ +++ I A+ LL +
Sbjct: 116 IFGFLYWVASFSHIDDEVGSKMDIHNLATVITPNILYSKSNDPVDESFLAIEAVHLLIE 174
>CE17831 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 769
Score = 54.3 bits (129), Expect = 6e-07
Identities = 38/180 (21%), Positives = 76/180 (42%)
Query: 478 DFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDK 537
D F V L+ + + +P + + + + GI+RK+ ++ L+S I+
Sbjct: 384 DGAVFGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIES 443
Query: 538 DPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKN 597
N + + + ++ V LLK +F +LP+ L+ +M+E S+ R
Sbjct: 444 YSGNTDVFVGENLLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERIT 503
Query: 598 YMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDV 657
+ I LPD ++ L+ LK + + N M + L + + P++ L+ V
Sbjct: 504 ALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQLGASRLDKV 563
>CE01007 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 649
Score = 54.3 bits (129), Expect = 6e-07
Identities = 38/180 (21%), Positives = 76/180 (42%)
Query: 478 DFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDK 537
D F V L+ + + +P + + + + GI+RK+ ++ L+S I+
Sbjct: 264 DGAVFGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIES 323
Query: 538 DPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKN 597
N + + + ++ V LLK +F +LP+ L+ +M+E S+ R
Sbjct: 324 YSGNTDVFVGENLLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERIT 383
Query: 598 YMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNEDLNDV 657
+ I LPD ++ L+ LK + + N M + L + + P++ L+ V
Sbjct: 384 ALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQLGASRLDKV 443
>CE21517 [T] KOG4270 GTPase-activator protein
Length = 604
Score = 53.9 bits (128), Expect = 8e-07
Identities = 41/184 (22%), Positives = 83/184 (44%), Gaps = 12/184 (6%)
Query: 475 TAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSE 534
TA F VPL+ L ++ + ++ +C + + G+N GI+R S N + R+++
Sbjct: 232 TALPRPVFGVPLDEHLSIQKERISGVLTKCCDFLRQNGMNERGIFRVSGNASKIKRIRAA 291
Query: 535 IDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTT 594
+D + + + ++D + V S LK + LPD L + + +++E
Sbjct: 292 LDAGQFDA-----DEKHYNNDPHAVASTLKAYLRELPDPLTMDSLQSDWVEAINLE-GEE 345
Query: 595 RKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNR---MGLKALCIIWGPTIISPNN 651
R + + + K+ G + LI+ +K + + E K M L I++ PT+
Sbjct: 346 RFSAIDRCLKKMTRGHR---QNLIYLMKFLCDLEAKREETSMNASNLAIVFAPTMTGMIY 402
Query: 652 EDLN 655
+ +N
Sbjct: 403 DGMN 406
>Hs14042955 [R] KOG3564 GTPase-activating protein
Length = 628
Score = 53.5 bits (127), Expect = 1e-06
Identities = 51/212 (24%), Positives = 87/212 (40%), Gaps = 24/212 (11%)
Query: 462 PSTVQTIGSLPPGTAKDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRK 521
P+ + T + G DF + P+ +P IV C+ I++ GL G+YR
Sbjct: 337 PTLIGTPVKIGEGMLADFVSQTFPM----------IPRIVVHCVNEIEQRGLTETGLYR- 385
Query: 522 SANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTE 581
+ S + + + P DI+ + SLLK F N + LL + +
Sbjct: 386 ------ILGCDSTVKLKEKFLRVKTVPLVSKVDDIHAICSLLKDFLRNFKEPLLTFRLNK 439
Query: 582 EIKTCLSIEDSTTRKNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCII 641
I D + M+ + +LP T+ L+ HL+R+ + +M + L +
Sbjct: 440 AFMEAAEITDEDNSISAMYQAVGELPQANRDTLVFLMIHLQRVAQ-SPYTKMNVANLAEV 498
Query: 642 WGPTIIS---PNNED---LNDVNYQISAMELL 667
+G TI++ PN E L D+ Q +E L
Sbjct: 499 FGSTIVAHAVPNPEPVTMLQDIKCQPKVVERL 530
>At5g19390 [T] KOG4271 Rho-GTPase activating protein
Length = 897
Score = 53.5 bits (127), Expect = 1e-06
Identities = 37/158 (23%), Positives = 68/158 (42%), Gaps = 9/158 (5%)
Query: 493 DQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYT 552
D D P+ + + + I+KYG +EGI R+SA+V +V R E ++ +
Sbjct: 206 DIDGSPSFLEKALQFIEKYGTKIEGILRQSADVEEVERRVQEYEQGKTEFTF-------- 257
Query: 553 DSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMHGIIYK-LPDGQY 611
D D ++VG +K LP + + + IE R + + I + P+
Sbjct: 258 DEDPHVVGDCIKHVLRELPSSPVSASCCTALLEAYRIESKEARISSLRSAIAETFPEPNR 317
Query: 612 WTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISP 649
++ ++ + I H +NRM A+ P ++ P
Sbjct: 318 RLLQRILKMMHTISSHSHENRMNPNAVAACMAPLLLRP 355
>Hs7661882 [T] KOG4270 GTPase-activator protein
Length = 638
Score = 53.1 bits (126), Expect = 1e-06
Identities = 46/178 (25%), Positives = 75/178 (41%), Gaps = 13/178 (7%)
Query: 482 FAVPLENLLDYDQD----LVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDK 537
F L+ + Y+Q LVP +V +C I ++G N EGI+R V +L+ D
Sbjct: 150 FGQRLDETVAYEQKFGPHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDA 209
Query: 538 DPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTC--LSIEDSTTR 595
P D+D++ V SLLK + +LP+ ++P E C L+ D
Sbjct: 210 GER-------PSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKA 262
Query: 596 KNYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED 653
+ + + LP Y + + L I + N+M + L + G +I ED
Sbjct: 263 QQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVED 320
>At5g12150 [T] KOG4271 Rho-GTPase activating protein
Length = 827
Score = 52.8 bits (125), Expect = 2e-06
Identities = 34/153 (22%), Positives = 67/153 (43%), Gaps = 9/153 (5%)
Query: 498 PAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEIDKDPSNVFMILPPKNYTDSDIY 557
P+ + + + ++ YG +EGI R+SA+V +V R E ++ + + D +
Sbjct: 181 PSFLEKALQFLETYGTKVEGILRQSADVEEVERRVQEYEQGKTEF--------SPEEDPH 232
Query: 558 LVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMH-GIIYKLPDGQYWTIRA 616
+VG +K LP + +P + I+ + R N + II P+ +
Sbjct: 233 VVGDCVKHVLRQLPSSPVPASCCTALLEAYKIDQNEARVNSLRSAIIETFPEPNRRLLLR 292
Query: 617 LIFHLKRILEHETKNRMGLKALCIIWGPTIISP 649
++ + I H ++NRM A+ P ++ P
Sbjct: 293 MLKMMHTITSHSSENRMTSSAVAACMSPLLLRP 325
>Hs16445031 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 995
Score = 52.0 bits (123), Expect = 3e-06
Identities = 40/174 (22%), Positives = 70/174 (39%), Gaps = 7/174 (4%)
Query: 477 KDFKTFAVPLENLLDYDQDLVPAIVRQCIYVIDKYGLNLEGIYRKSANVLDVSRLKSEID 536
KD F VPL + +P ++Q + + L+ G++RKS + L+ +
Sbjct: 538 KDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNE 597
Query: 537 KDPSNVFMILPPKNYTDSDIYLVGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRK 596
P NV NY D Y V ++K FF +LP+ L +++E R
Sbjct: 598 NFPENV-------NYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVSKEQRL 650
Query: 597 NYMHGIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPN 650
+ I L D ++ L+ L ++ +N+M L + P++ N
Sbjct: 651 QAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFHLN 704
>Hs20560839_1 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating
proteins
Length = 173
Score = 52.0 bits (123), Expect = 3e-06
Identities = 33/138 (23%), Positives = 68/138 (48%), Gaps = 10/138 (7%)
Query: 548 PKNYTDSDIYL-------VGSLLKTFFANLPDTLLPREMTEEIKTCLSIEDSTTRKNYMH 600
PK+ D DI + + S LK + L + L+ ++ ++ + +D R +H
Sbjct: 7 PKSPPDIDIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVH 66
Query: 601 GIIYKLPDGQYWTIRALIFHLKRILEHETKNRMGLKALCIIWGPTIISPNNED---LNDV 657
+++KLP+ + LI HL ++ H +N M + L +I+GPT++ E + ++
Sbjct: 67 ALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNI 126
Query: 658 NYQISAMELLFDVADQAF 675
+Q +E+L + ++ F
Sbjct: 127 KFQNIVVEILIEHYEKVF 144
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.313 0.130 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,691,820
Number of Sequences: 60738
Number of extensions: 1571053
Number of successful extensions: 5345
Number of sequences better than 1.0e-05: 90
Number of HSP's better than 0.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 5197
Number of HSP's gapped (non-prelim): 113
length of query: 678
length of database: 30,389,216
effective HSP length: 113
effective length of query: 565
effective length of database: 23,525,822
effective search space: 13292089430
effective search space used: 13292089430
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)