ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0859 good R KOG3867 General function prediction only Sulfatase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0859 292882 291218 -555
(555 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
SPBPB10D8.02c [R] KOG3867 Sulfatase 556 e-158
Hs4557333 [R] KOG3867 Sulfatase 117 5e-26
7293940_1 [R] KOG3867 Sulfatase 112 2e-24
7303418 [R] KOG3867 Sulfatase 100 6e-21
7293925 [R] KOG3867 Sulfatase 90 1e-17
Hs4503899 [R] KOG3867 Sulfatase 80 6e-15
Hs7662440 [R] KOG3867 Sulfatase 79 2e-14
Hs6005990 [R] KOG3867 Sulfatase 75 3e-13
Hs4506919 [R] KOG3867 Sulfatase 74 4e-13
7300451 [R] KOG3867 Sulfatase 74 4e-13
Hs4502237 [R] KOG3867 Sulfatase 65 3e-10
Hs4502241 [R] KOG3867 Sulfatase 64 8e-10
CE07003 [R] KOG3867 Sulfatase 64 8e-10
Hs6806885 [R] KOG3867 Sulfatase 63 1e-09
Hs4502239 [R] KOG3867 Sulfatase 63 1e-09
Hs20553185 [R] KOG3867 Sulfatase 61 4e-09
Hs14766617 [R] KOG3867 Sulfatase 59 2e-08
Hs22042324 [R] KOG3867 Sulfatase 59 3e-08
Hs4757782 [R] KOG3867 Sulfatase 58 4e-08
Hs22052681 [R] KOG3867 Sulfatase 51 4e-06
>SPBPB10D8.02c [R] KOG3867 Sulfatase
Length = 554
Score = 556 bits (1434), Expect = e-158
Identities = 284/543 (52%), Positives = 370/543 (67%), Gaps = 16/543 (2%)
Query: 3 KTDEPKKPNFLIIVADDLGFTDVSSFGGEIQTPNLDKLSKGGFRFTGFHTASACSPTRSM 62
K E KKPNFL+IVADDLG++DVS FG EI TPN+++L+K G R T FHTASACSPTRSM
Sbjct: 5 KQAESKKPNFLVIVADDLGWSDVSPFGSEIHTPNIERLAKEGVRLTNFHTASACSPTRSM 64
Query: 63 LLSGTDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE-YYTLISGKW 121
LLSGTDNH+AGLGQMAE R+F + + KPGYEGYLN +VAALPEIL YYT +SGKW
Sbjct: 65 LLSGTDNHIAGLGQMAETVRRFSKVWGGKPGYEGYLNDRVAALPEILQEAGYYTTMSGKW 124
Query: 122 HLGLEKPYWPSDRGFQKRFTLLPGAGNHFKCNLDSKF-----LLPWIYQENGERVDHNKF 176
HLGL +PS RGF++ F LLPG GNHF ++ LP +Y N + VDH K
Sbjct: 125 HLGLTPDRYPSKRGFKESFALLPGGGNHFAYEPGTRENPAVPFLPPLYTHNHDPVDH-KS 183
Query: 177 PENFYSTTYFTDKFLEYLKDDEERKGRPFFGQLTYTAPHWPLQAPAETIAKYKGKYNGGP 236
+NFYS+ YF +K ++ LK+ E K + FF L +TAPHWPLQ+P E I KY+G+Y+ GP
Sbjct: 184 LKNFYSSNYFAEKLIDQLKNRE--KSQSFFAYLPFTAPHWPLQSPKEYINKYRGRYSEGP 241
Query: 237 XXXXXXXXXXXXDLGIVPADVVAHLVETQREKTWDELDDKGKAYESRIMEIYAAMVDELD 296
DLG++P +V+ V+ K+WDEL + K + +R ME+YAAMV+ LD
Sbjct: 242 DVLRKNRLQAQKDLGLIPENVIPAPVDGMGTKSWDELTTEEKEFSARTMEVYAAMVELLD 301
Query: 297 QNIGRVIDHLKETDEFDNTVIMFMSDNGAEGMLMEALPFGGSTFKERISSDYNNDFDNIG 356
NIGRVID+LK E DNT ++FMSDNGAEG ++EA+P + + ++N +N+G
Sbjct: 302 LNIGRVIDYLKTIGELDNTFVIFMSDNGAEGSVLEAIPVLSTKPPVKY---FDNSLENLG 358
Query: 357 KTNSFVYYGDLWAQAATAPNYMYKMWATEGGINCPLILHAPQLTGLWEPGQIIDQFTTVM 416
NSF++YG WAQAATAP+ + K + TEGGI CP I+ P L +P I D+F TVM
Sbjct: 359 NYNSFIWYGPRWAQAATAPSRLSKGFITEGGIRCPAIIRYPPLI---KPDIISDEFVTVM 415
Query: 417 DILPSVLELANVPHPGTSFEGRKVHEPRGLSWIPFLKKESERIYDDTRVTGWELFGQRAI 476
DILP++LELA VPHPG F+GR V PRG WI + ++ DT +GWELFGQRAI
Sbjct: 416 DILPTILELAEVPHPGHKFQGRDVVIPRGKPWIDHF-VHGKPVHKDTDFSGWELFGQRAI 474
Query: 477 RQGPYKGVYIPPPFGPGHWLLFNIDEDPGETTDLSKEHPDILEKIIDHWSVYKAETGLIE 536
R+G YK +Y+P W L+++ +D GE +L+K HPDIL ++I++W VY+AETG++
Sbjct: 475 RKGNYKAIYVPKEGIKTEWELYDLSQDKGELENLAKVHPDILNELIEYWLVYEAETGVVT 534
Query: 537 LED 539
D
Sbjct: 535 APD 537
>Hs4557333 [R] KOG3867 Sulfatase
Length = 533
Score = 117 bits (293), Expect = 5e-26
Identities = 142/570 (24%), Positives = 220/570 (37%), Gaps = 156/570 (27%)
Query: 8 KKPNFLIIVADDLGFTDVSSFGGEIQTPNLDKLSKGGFRFTGFHTASACSPTRSMLLSGT 67
+ P+ + ++ADDLG+ DV G I+TP+LD L+ GG ++T C+P+RS LL+G
Sbjct: 43 RPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGR 102
Query: 68 DNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPEYYTL-ISGKWHLGL- 125
GL + P + LP++L YT + GKWHLG+
Sbjct: 103 YQIRTGLQHQIIW-----------PCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMY 151
Query: 126 EKPYWPSDRGFQKRFTLLPGAG---NHFKCNLDSKFLLPWIYQE--NGERVDHNKFPENF 180
K P+ RGF F L G+ +H +C L + + +GE V +N
Sbjct: 152 RKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGY--KNM 209
Query: 181 YSTTYFTDKFLEYLKDDEERKGRPFFGQLTYTAPHWPLQAPAETIAKYKGKYNGGPXXXX 240
YST FT + + + + K P F L + H PLQ P E +
Sbjct: 210 YSTNIFTKRAIALITNHPPEK--PLFLYLALQSVHEPLQVPEEYL--------------- 252
Query: 241 XXXXXXXXDLGIVPADVVAHLVETQREKTWDELDDKGKAYESRIMEIYAAMVDELDQNIG 300
K +D + DK + + YA MV +D+ +G
Sbjct: 253 ---------------------------KPYDFIQDKNRHH-------YAGMVSLMDEAVG 278
Query: 301 RVIDHLKETDEFDNTVIMFMSDNGAEGMLMEALPFGGSTFKERISSDYNNDFDNIGKTNS 360
V LK + ++NTV +F +DNG + + GG N+
Sbjct: 279 NVTAALKSSGLWNNTVFIFSTDNGGQTLA------GG---------------------NN 311
Query: 361 FVYYGDLWAQAATAPNYMYKMWATEGGINCPLILHAPQLTGLWEPGQIIDQFTTVMDILP 420
+ G W+ +W EGG+ + +P L + G + + D LP
Sbjct: 312 WPLRGRKWS-----------LW--EGGVRGVGFVASPLLK---QKGVKNRELIHISDWLP 355
Query: 421 SVLELA----NVPHPGTSFEGRK-------------VH--EPRGLSWIPFLKKESERIYD 461
++++LA N P F+ K +H +P + P + D
Sbjct: 356 TLVKLARGHTNGTKPLDGFDMWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKD 415
Query: 462 DTRVTGWELFG---QRAIRQGPYK--------GVYIPPPF-----------GPGHWL-LF 498
D+ + + F AIR G +K G + PPP P L LF
Sbjct: 416 DSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLF 475
Query: 499 NIDEDPGETTDLSKEHPDILEKIIDHWSVY 528
+ID DP E DLS+E+P I+ K++ Y
Sbjct: 476 DIDRDPEERHDLSREYPHIVTKLLSRLQFY 505
>7293940_1 [R] KOG3867 Sulfatase
Length = 679
Score = 112 bits (279), Expect = 2e-24
Identities = 98/342 (28%), Positives = 148/342 (42%), Gaps = 78/342 (22%)
Query: 3 KTDEP---KKPNFLIIVADDLGFTDVSSFGG-EIQTPNLDKLSKGGFRFTGFHTASACSP 58
K+DE ++PN +II+ADD+GF DVS GG E TPN+D L+ G + + C+P
Sbjct: 17 KSDESAAARRPNIIIIMADDMGFDDVSFRGGREFLTPNIDALAYHGRLLDRLYAPAMCTP 76
Query: 59 TRSMLLSGTDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE-YYTLI 117
+R LLSG G + F L +PEI Y T +
Sbjct: 77 SRGALLSGRYPIHTG-----------TQHFVISNEEPWALTLNATLMPEIFKEAGYSTNL 125
Query: 118 SGKWHLGLEKP-YWPSDRGFQKRFTLLPGAGNHFKCNLD---SKFLLPWIYQENGERVDH 173
GKWHLG +P Y P+ RGF F ++F+ + + L + ++ N E
Sbjct: 126 VGKWHLGFSRPEYTPTRRGFDYHFGYWGAYIDYFQRRSKMPVANYSLGYDFRRNMELECR 185
Query: 174 NKFPENFYSTTYFTDKFLEYLKDDEERKGRPFFGQLTYTAPHW-----PLQAPAETIAKY 228
++ Y T T + +KD + K +P F L++ A H PLQAP E I K+
Sbjct: 186 DR---GVYVTDLLTAEAERLIKDHAD-KEQPLFLMLSHLAAHTANEDDPLQAPEEEIQKF 241
Query: 229 KGKYNGGPXXXXXXXXXXXXDLGIVPADVVAHLVETQREKTWDELDDKGKAYESRIMEIY 288
+++ + R K Y
Sbjct: 242 ------------------------------SYIKDPNRRK-------------------Y 252
Query: 289 AAMVDELDQNIGRVIDHLKETDEFDNTVIMFMSDNGAEGMLM 330
AAM+ +LDQ++GR+I L TD+ +N++++F SDNGA + M
Sbjct: 253 AAMISKLDQSVGRIITALSSTDQLENSIVIFYSDNGAPSVGM 294
>7303418 [R] KOG3867 Sulfatase
Length = 542
Score = 100 bits (249), Expect = 6e-21
Identities = 89/328 (27%), Positives = 137/328 (41%), Gaps = 96/328 (29%)
Query: 7 PKKPNFLIIVADDLGFTDVSSFGG-EIQTPNLDKLSKGGFRFTGFHTASACSPTRSMLLS 65
P KPN + I+ADDLGF DV G EI TPN+D L+ G ++ A C+P+RS L++
Sbjct: 23 PAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYYVAPICTPSRSALMT 82
Query: 66 GTDNHLAGLGQMAEYA---RQFPEKFKDKPGYEGYLNYKVAALPEILSPEYYTLISGKWH 122
G G+ YA R P + K P Y L Y + I+GKWH
Sbjct: 83 GKYPIHTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYT-------------SHIAGKWH 129
Query: 123 LGLEK-PYWPSDRGFQKRFTLLPGAGNHFKCNLDSKFLLPWIYQENGERVDHNKFPENFY 181
LG K Y P RGF + LD + NG +V ++ Y
Sbjct: 130 LGHWKLKYTPLYRGFSSHW------------GLDMR---------NGTQVAYDL--HGHY 166
Query: 182 STTYFTDKFLEYLKDDEERKGRPFFGQLTYTA-----PHWPLQAPAETIAKYKGKYNGGP 236
+T TD ++ + + KG P F + + A P+ PL P + K
Sbjct: 167 TTDVITDHSVKVIANHNATKG-PLFLYVAHAACHSSNPYNPLPVPDNDVIK--------- 216
Query: 237 XXXXXXXXXXXXDLGIVPADVVAHLVETQREKTWDELDDKGKAYESRIMEIYAAMVDELD 296
++H+ +R K +AAMV ++D
Sbjct: 217 ---------------------MSHIPNYKRRK-------------------FAAMVSKMD 236
Query: 297 QNIGRVIDHLKETDEFDNTVIMFMSDNG 324
++G+++D L++++ +N++I+F SDNG
Sbjct: 237 NSVGQIVDQLRKSNMLENSIIIFSSDNG 264
>7293925 [R] KOG3867 Sulfatase
Length = 579
Score = 89.7 bits (221), Expect = 1e-17
Identities = 113/454 (24%), Positives = 183/454 (39%), Gaps = 94/454 (20%)
Query: 9 KPNFLIIVADDLGFTDVSSFGG-EIQTPNLDKLSKGGFRFTGFHTASACSPTRSMLLSGT 67
KPN +II+ DD+G DVS G +I TPN+D L+ G + + C+P+R+ LL+G
Sbjct: 27 KPNIVIILIDDMGMNDVSFHGSNQILTPNIDALAYNGILLNKHYVPNLCTPSRATLLTGK 86
Query: 68 DNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEIL-SPEYYTLISGKWHLGL- 125
G+ Q D+P L + +PEI Y T + GKWHLG
Sbjct: 87 YPIHTGM--------QHFVIITDEP---WGLPQRERLMPEIFRDAGYSTHLVGKWHLGFW 135
Query: 126 EKPYWPSDRGFQKRFTLLPGAGNHFKCNLDSKFLLPWIYQENGE-RVDHNKFPENFYSTT 184
K P+ RGF F G +++ + +L Y + R D PE + T
Sbjct: 136 RKDLTPTMRGFDHHFGYYNGYIDYYDHQVR---MLDRNYSAGLDFRRDLEPCPE--ANGT 190
Query: 185 YFTDKFLEYLKD--DEERKGRPFFGQLTYTAPHW-----PLQAPAETIAKYKGKYNGGPX 237
Y T+ F K ++ K +P F L++ A H P+QAP E +AK+
Sbjct: 191 YATEAFTSEAKRIIEQHDKSKPLFMVLSHLAVHTGNEDSPMQAPEEEVAKF--------- 241
Query: 238 XXXXXXXXXXXDLGIVPADVVAHLVETQREKTWDELDDKGKAYESRIMEIYAAMVDELDQ 297
H+ + +R YA M+ LD+
Sbjct: 242 ---------------------PHIRDPKR-------------------RTYAGMISSLDK 261
Query: 298 NIGRVIDHLKETDEFDNTVIMFMSDNGAEGMLMEALPFGGSTFKERISSDYNNDFDNIGK 357
++ + I LK+ +N++I+ SDNGA + + + ++ + S + + G
Sbjct: 262 SVAQTIGALKDNGMLNNSIILLYSDNGAPTIGIHSNAGSNYPYRGQKESPWEGGIRSAGA 321
Query: 358 TNS--FVYYGDLWAQAATAPNYMYKMWATEGGINCPLILHA------PQLTGLWEPG--- 406
S G + QA A +++ + A G++ P L P L+G EP
Sbjct: 322 LWSPLLKERGYVSNQAIHAVDWLPTL-AGAAGVSLPQDLPLDGINLWPMLSGNEEPKPRT 380
Query: 407 --QIIDQFTTVMDILPSVLELANVPHPGTSFEGR 438
++D+ + L+ N G+SF+GR
Sbjct: 381 MIHVLDEVFGYSSYMRDTLKYVN----GSSFKGR 410
>Hs4503899 [R] KOG3867 Sulfatase
Length = 522
Score = 80.5 bits (197), Expect = 6e-15
Identities = 110/444 (24%), Positives = 173/444 (38%), Gaps = 120/444 (27%)
Query: 1 MTKTDEPKKPNFLIIVADDLGFTDVSSFGGEI-QTPNLDKLSKGGFRFTGFHTASA-CSP 58
M + P+ PN L+++ DD+G+ D+ +G +TPNLD+++ G F F++A+ CSP
Sbjct: 22 MGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSP 81
Query: 59 TRSMLLSGTDNHLAGLGQMAEYARQF--PEKFKDKPGYEGYLNYKVAALPEILSPE-YYT 115
+R+ LL+G G +AR P++ G + LPE+L Y +
Sbjct: 82 SRAALLTGRLPIRNGFYTTNAHARNAYTPQEIV------GGIPDSEQLLPELLKKAGYVS 135
Query: 116 LISGKWHLGLEKPYWPSDRGFQKRFTLLPGAGNHFKCNLDSKFLLPWIYQENGERVD--H 173
I GKWHLG + P GF + F G+ N D+K + E V +
Sbjct: 136 KIVGKWHLGHRPQFHPLKHGFDEWF----GSPNCHFGPYDNKARPNIPVYRDWEMVGRYY 191
Query: 174 NKFPENFYS-----TTYFTDKFLEYLKDDEERKGRPFFGQLTYTAPHWPLQAPAETI-AK 227
+FP N + T + + L+++K + + PFF A H P+ A +
Sbjct: 192 EEFPINLKTGEANLTQIYLQEALDFIK--RQARHHPFFLYWAVDATHAPVYASKPFLGTS 249
Query: 228 YKGKYNGGPXXXXXXXXXXXXDLGIVPADVVAHLVETQREKTWDELDDKGKAYESRIMEI 287
+G+Y D V E+DD
Sbjct: 250 QRGRY----------------------GDAVR------------EIDD------------ 263
Query: 288 YAAMVDELDQNIGRVIDHLKETDEFDNTVIMFMSDNGAEGMLMEALPFGGSTFKERISSD 347
+IG++++ L++ DNT + F SDNGA L+ A GGS
Sbjct: 264 ----------SIGKILELLQDLHVADNTFVFFTSDNGA--ALISAPEQGGS--------- 302
Query: 348 YNNDFDNIGKTNSFVYYGDLWAQAATAPNYMYKMWATEGGINCPLILHAPQLTGLWEPGQ 407
N F GK +F EGG+ P + P G GQ
Sbjct: 303 -NGPF-LCGKQTTF-----------------------EGGMREPALAWWP---GHVTAGQ 334
Query: 408 IIDQFTTVMDILPSVLELANVPHP 431
+ Q ++MD+ + L LA + P
Sbjct: 335 VSHQLGSIMDLFTTSLALAGLTPP 358
>Hs7662440 [R] KOG3867 Sulfatase
Length = 525
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/136 (40%), Positives = 70/136 (51%), Gaps = 15/136 (11%)
Query: 8 KKPNFLIIVADDLGFTDVSSFGGEIQ-TPNLDKLSKGGFRFTGFHTA-SACSPTRSMLLS 65
+KPNF+II+ADD+G+ D+ + E + T NLDK++ G RF FH A S CSP+R+ LL+
Sbjct: 34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLT 93
Query: 66 GTDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE-YYTLISGKWHLG 124
G LG R F G L L E+L Y T I GKWHLG
Sbjct: 94 GR------LGLRNGVTRNFAVTSV------GGLPLNETTLAEVLQQAGYVTGIIGKWHLG 141
Query: 125 LEKPYWPSDRGFQKRF 140
Y P+ RGF F
Sbjct: 142 HHGSYHPNFRGFDYYF 157
>Hs6005990 [R] KOG3867 Sulfatase
Length = 507
Score = 74.7 bits (182), Expect = 3e-13
Identities = 105/448 (23%), Positives = 171/448 (37%), Gaps = 129/448 (28%)
Query: 8 KKPNFLIIVADDLGFTDVSSFGGEIQT-PNLDKLSKGGFRFTGFHT-ASACSPTRSMLLS 65
+ PN ++I ADDLG+ D+ +G T PNLD+L+ GG RFT F+ S C+P+R+ LL+
Sbjct: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLT 78
Query: 66 GTDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE-YYTLISGKWHLG 124
G++ +P P G L + + E+L+ Y T ++GKWHLG
Sbjct: 79 ---------GRLPVRMGMYPGVL--VPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLG 127
Query: 125 L--EKPYWPSDRGFQKRFTLLPGAGNHFKCNLDSKFLLPWIYQENGERVDHNKFPENFYS 182
+ E + P +GF RF +P + + C + F P + G D P +
Sbjct: 128 VGPEGAFLPPHQGFH-RFLGIPYSHDQGPCQNLTCF-PPATPCDGG--CDQGLVPIPLLA 183
Query: 183 TTYFTDK-------------FLEYLKDDEERKGRPFFGQLTYTAPHWPLQAPAETIAKYK 229
+ F L D +R+ RPFF H+P Q ++ A+
Sbjct: 184 NLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFAERS 242
Query: 230 GKYNGGPXXXXXXXXXXXXDLGIVPADVVAHLVETQREKTWDELDDKGKAYESRIMEIYA 289
G+ GP + +ME+ A
Sbjct: 243 GR---GP-------------------------------------------FGDSLMELDA 256
Query: 290 AMVDELDQNIGRVIDHLKETDEFDNTVIMFMSDNGAEGMLMEALPFGGSTFKERISSDYN 349
A +G ++ + + + T+++F +DNG E M M GG + R
Sbjct: 257 A--------VGTLMTAIGDLGLLEETLVIFTADNGPETMRMSR---GGCSGLLR------ 299
Query: 350 NDFDNIGKTNSFVYYGDLWAQAATAPNYMYKMWATEGGINCPLILHAPQLTGLWEPGQII 409
GK ++ EGG+ P + P G PG +
Sbjct: 300 -----CGKGTTY-----------------------EGGVREPALAFWP---GHIAPG-VT 327
Query: 410 DQFTTVMDILPSVLELANVPHPGTSFEG 437
+ + +D+LP++ LA P P + +G
Sbjct: 328 HELASSLDLLPTLAALAGAPLPNVTLDG 355
>Hs4506919 [R] KOG3867 Sulfatase
Length = 502
Score = 74.3 bits (181), Expect = 4e-13
Identities = 101/452 (22%), Positives = 165/452 (36%), Gaps = 127/452 (28%)
Query: 11 NFLIIVADDLGFTDVSSFGGEIQTPNLDKLSKGGFRF-TGFHTASACSPTRSMLLSGTDN 69
N L+++ADD GF + I TP+LD L++ F F + S+CSP+R+ LL+G
Sbjct: 24 NALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQ 83
Query: 70 H---LAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE-YYTLISGKWHLGL 125
H + GL Q + F KV +LP +LS T I GK H+G
Sbjct: 84 HQNGMYGLHQDVHHFNSFD---------------KVRSLPLLLSQAGVRTGIIGKKHVGP 128
Query: 126 EKPYWPSDRGFQKRFTLLPGAGNHFKCNLDSKFLLPWIYQENGERVDHNKFPENFYSTTY 185
E Y P D + +ENG + + N
Sbjct: 129 ETVY-PFDFAYT---------------------------EENGSVLQVGR---NITRIKL 157
Query: 186 FTDKFLEYLKDDEERKGRPFFGQLTYTAPH--WPLQAPAETIAKYKGKYNGGPXXXXXXX 243
KFL+ D RPFF + + PH Q T + G G
Sbjct: 158 LVRKFLQTQDD------RPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWT 211
Query: 244 XXXXXDLGIVPADVVAHLVETQREKTWDELDDKGKAYESRIMEIYAAMVDELDQNIGRVI 303
L ++ V + + + + V +DQ +G V+
Sbjct: 212 PQAYDPLDVLVPYFVPNTPAARAD-----------------LAAQYTTVGRMDQGVGLVL 254
Query: 304 DHLKETDEFDNTVIMFMSDNGAEGMLMEALPFGGSTFKERISSDYNNDFDNIGKTNSFVY 363
L++ ++T+++F SDNG +PF G+TN +
Sbjct: 255 QELRDAGVLNDTLVIFTSDNG--------IPFPS------------------GRTNLY-- 286
Query: 364 YGDLWAQAATAPNYMYKMWATEGGINCPLILHAPQLTGLWEPGQIIDQFTTVMDILPSVL 423
W A PL++ +P+ W GQ+ + + +++D+ P++L
Sbjct: 287 ----WPGTAE-----------------PLLVSSPEHPKRW--GQVSEAYVSLLDLTPTIL 323
Query: 424 ELANVPHPGTSFEGRKVHEPRGLSWIPFLKKE 455
+ ++P+P + G K G S +P L+ E
Sbjct: 324 DWFSIPYPSYAIFGSKTIHLTGRSLLPALEAE 355
>7300451 [R] KOG3867 Sulfatase
Length = 524
Score = 74.3 bits (181), Expect = 4e-13
Identities = 109/513 (21%), Positives = 191/513 (36%), Gaps = 154/513 (30%)
Query: 11 NFLIIVADDLGFTDVSSFGGEIQTPNLDKLSKGGFRF-TGFHTASACSPTRSMLLSGTDN 69
N L+++ADD GF + QTPNLD L+K G F F + S+CSP+RS LL+G
Sbjct: 22 NVLLLLADDAGFESGAYLNKFCQTPNLDALAKRGLLFNNAFTSVSSCSPSRSQLLTGQAG 81
Query: 70 HLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKV----AALPEILSPE----YYTLISGKW 121
H +G+ + ++G N+ V +LP ++ + + I GK
Sbjct: 82 HSSGMYGL----------------HQGVHNFNVLPDTGSLPNLIRDQSGGRILSGIIGKK 125
Query: 122 HLGLEKPYWPSDRGFQKRFTLLPGAGNHFKCNLDSKFLLPWIYQENGERVDHNKFPENFY 181
H+ GA N+F+ + +++ E+ N+ N
Sbjct: 126 HV---------------------GAANNFRFD----------FEQTEEQHSINQIGRNIT 154
Query: 182 STTYFTDKFLEYLKDDEERKGRPFFGQLTYTAPHWPLQAPAETIAKYKGKYNGGPXXXXX 241
+ +FL+ KD++ +PFF + + PH + ++ ++ G
Sbjct: 155 RMKEYARQFLKQAKDEK----KPFFLMVGFHDPHRCGHITPQ-FGEFCERWGSG------ 203
Query: 242 XXXXXXXDLGIVPADVVAHLVETQREKTWDELDDKGKAYESRIMEIYAA----MVDELDQ 297
+G +P + W LD ++ ++ A + LDQ
Sbjct: 204 -----EEGMGSIPDWKPIYY-------DWRNLDVPAWLPDTDVVRQELAAQYMTISRLDQ 251
Query: 298 NIGRVIDHLKETDEFDNTVIMFMSDNGAEGMLMEALPFGGSTFKERISSDYNNDFDNIGK 357
+G ++ L+ D T++++ SDNG PF G G+
Sbjct: 252 GVGLMLKELEAAGVADQTLVIYTSDNGP--------PFPG------------------GR 285
Query: 358 TNSFVYYGDLWAQAATAPNYMYKMWATEGGINCPLILHAPQLTGLWEPGQIIDQFTTVMD 417
TN + E GI PLI+ +P + +++D
Sbjct: 286 TNLY-----------------------EHGIRSPLIISSPNKED--RHHEATAAMVSLLD 320
Query: 418 ILPSVLELANVPHPG-TSFEGRKVHEPRGLSWIPFLK-----KESERIYDDTRVTGWEL- 470
I PSV++ +P P T GR + +P L+ KES+ ++ +
Sbjct: 321 IYPSVMDALQIPRPNDTKIVGRSI--------LPVLREEPPIKESDSVFGSHSYHEVTMA 372
Query: 471 FGQRAIRQGPYKGVYIPPPFGPGHWLLFNIDED 503
+ R +R YK ++ +W F ID+D
Sbjct: 373 YPMRMVRNRRYKLIH-----NINYWADFPIDQD 400
>Hs4502237 [R] KOG3867 Sulfatase
Length = 583
Score = 65.1 bits (157), Expect = 3e-10
Identities = 40/125 (32%), Positives = 67/125 (53%), Gaps = 7/125 (5%)
Query: 3 KTDEPKKPNFLIIVADDLGFTDVSSFGGE-IQTPNLDKLSKGGFRFTGFHTAS-ACSPTR 60
++ E +PN ++++ADDLG D +G + I+TPN+D+L+ GG + T AS C+P+R
Sbjct: 20 ESHEASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSR 79
Query: 61 SMLLSGTDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPEYYTLISGK 120
+ ++G +G MA ++R F G G ++ + Y T + GK
Sbjct: 80 AAFMTGRYPVRSG---MASWSRTGVFLFTASSG--GLPTDEITFAKLLKDQGYSTALIGK 134
Query: 121 WHLGL 125
WHLG+
Sbjct: 135 WHLGM 139
>Hs4502241 [R] KOG3867 Sulfatase
Length = 589
Score = 63.5 bits (153), Expect = 8e-10
Identities = 40/120 (33%), Positives = 63/120 (52%), Gaps = 9/120 (7%)
Query: 9 KPNFLIIVADDLGFTDVSSFGGE-IQTPNLDKLSKGGFRFT-GFHTASACSPTRSMLLSG 66
+PN L+++ADDLG D+ +G ++TPN+D+L++ G + T AS C+P+R+ L+G
Sbjct: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTG 96
Query: 67 TDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE-YYTLISGKWHLGL 125
+G+ Y + G G L +IL + Y T + GKWHLGL
Sbjct: 97 RYPVRSGMVSSIGY------RVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGL 150
>CE07003 [R] KOG3867 Sulfatase
Length = 452
Score = 63.5 bits (153), Expect = 8e-10
Identities = 47/168 (27%), Positives = 81/168 (47%), Gaps = 33/168 (19%)
Query: 7 PKKPNFLIIVADDLGFTDVSSFGGEIQT-PNLDKLSKGGFRFTGFHTA-SACSPTRSMLL 64
P+ PN +I++ DDLG+ D++S+G Q +D+++ G RFT ++A S CSP+R+ +
Sbjct: 30 PRHPNIVILMIDDLGYGDIASYGHPTQEYTQVDRMAAEGTRFTQAYSADSMCSPSRAGFI 89
Query: 65 SGTDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPE--------ILSPEYYTL 116
+G + P + G ++ Y + LP+ + Y T
Sbjct: 90 TG----------------RLPIRLGIVGGRRVFVPYDIGGLPKSETTMAEMLQEAGYATG 133
Query: 117 ISGKWHLGLEK------PYWPSDRGFQKRFTLLPGAGNHFKCNLDSKF 158
+ GKWHLG+ + + PS RGF+ LP N ++C+ +F
Sbjct: 134 MVGKWHLGINENNATDGAHLPSKRGFEYVGVNLPFT-NVWQCDTTREF 180
>Hs6806885 [R] KOG3867 Sulfatase
Length = 382
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/133 (33%), Positives = 68/133 (51%), Gaps = 14/133 (10%)
Query: 1 MTKTDEPK-----KPNFLIIVADDLGFTDVSSFGGE-IQTPNLDKLSKGGFRFTGFHTAS 54
+ KT EPK KPN L+I+ADDLG D+ +G ++TPN+D+L++ G R T H A+
Sbjct: 27 LLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQ-HLAA 85
Query: 55 A--CSPTRSMLLSGTDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE 112
A C+P+R+ L+G + +G+ Y + G G + +
Sbjct: 86 APLCTPSRAAFLTGRHSFRSGMDASNGY-----RALQWNAGSGGLPENETTFARILQQHG 140
Query: 113 YYTLISGKWHLGL 125
Y T + GKWH G+
Sbjct: 141 YATGLIGKWHQGV 153
>Hs4502239 [R] KOG3867 Sulfatase
Length = 593
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/133 (33%), Positives = 68/133 (51%), Gaps = 14/133 (10%)
Query: 1 MTKTDEPK-----KPNFLIIVADDLGFTDVSSFGGE-IQTPNLDKLSKGGFRFTGFHTAS 54
+ KT EPK KPN L+I+ADDLG D+ +G ++TPN+D+L++ G R T H A+
Sbjct: 27 LLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQ-HLAA 85
Query: 55 A--CSPTRSMLLSGTDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE 112
A C+P+R+ L+G + +G+ Y + G G + +
Sbjct: 86 APLCTPSRAAFLTGRHSFRSGMDASNGY-----RALQWNAGSGGLPENETTFARILQQHG 140
Query: 113 YYTLISGKWHLGL 125
Y T + GKWH G+
Sbjct: 141 YATGLIGKWHQGV 153
>Hs20553185 [R] KOG3867 Sulfatase
Length = 688
Score = 61.2 bits (147), Expect = 4e-09
Identities = 44/137 (32%), Positives = 66/137 (48%), Gaps = 14/137 (10%)
Query: 9 KPNFLIIVADDLGFTDVSSFG-GEIQTPNLDKLSKGGFRFT-GFHTASACSPTRSMLLSG 66
+PN ++++ADDLG D+ +G + TPN+D+L+ G R T AS C+P+R+ L+G
Sbjct: 132 RPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTG 191
Query: 67 TDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE-YYTLISGKWHLGL 125
+G+ R F G G L ++L Y T + GKWHLGL
Sbjct: 192 RYPIRSGMVSAYNLNRAFTWL-----GGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGL 246
Query: 126 ------EKPYWPSDRGF 136
+ Y P + GF
Sbjct: 247 SCASRNDHCYHPLNHGF 263
>Hs14766617 [R] KOG3867 Sulfatase
Length = 590
Score = 58.9 bits (141), Expect = 2e-08
Identities = 40/120 (33%), Positives = 63/120 (52%), Gaps = 9/120 (7%)
Query: 9 KPNFLIIVADDLGFTDVSSFGGE-IQTPNLDKLSKGGFRFT-GFHTASACSPTRSMLLSG 66
KPN ++I+ DDLG D+ +G + ++TP++D+L++ G R T AS CSP+RS L+G
Sbjct: 29 KPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTG 88
Query: 67 TDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE-YYTLISGKWHLGL 125
+ G ++ R+ + G L L +L + Y T + GKWH GL
Sbjct: 89 --RYPIRSGMVSSGNRRVIQNLAVPAG----LPLNETTLAALLKKQGYSTGLIGKWHQGL 142
>Hs22042324 [R] KOG3867 Sulfatase
Length = 305
Score = 58.5 bits (140), Expect = 3e-08
Identities = 25/63 (39%), Positives = 38/63 (59%)
Query: 4 TDEPKKPNFLIIVADDLGFTDVSSFGGEIQTPNLDKLSKGGFRFTGFHTASACSPTRSML 63
T +P+ + I+ADD GF DV G EI+TP LDKL+ G + ++ C+P+RS
Sbjct: 162 TTSTSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQPICTPSRSQF 221
Query: 64 LSG 66
++G
Sbjct: 222 ITG 224
>Hs4757782 [R] KOG3867 Sulfatase
Length = 591
Score = 57.8 bits (138), Expect = 4e-08
Identities = 39/120 (32%), Positives = 63/120 (52%), Gaps = 9/120 (7%)
Query: 9 KPNFLIIVADDLGFTDVSSFGGE-IQTPNLDKLSKGGFRFT-GFHTASACSPTRSMLLSG 66
+PN ++I+ DDLG D+ +G + ++TP++D+L++ G R T AS CSP+RS L+G
Sbjct: 30 RPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTG 89
Query: 67 TDNHLAGLGQMAEYARQFPEKFKDKPGYEGYLNYKVAALPEILSPE-YYTLISGKWHLGL 125
+ G ++ R+ + G L L +L + Y T + GKWH GL
Sbjct: 90 --RYPIRSGMVSSGNRRVIQNLAVPAG----LPLNETTLAALLKKQGYSTGLIGKWHQGL 143
>Hs22052681 [R] KOG3867 Sulfatase
Length = 178
Score = 51.2 bits (121), Expect = 4e-06
Identities = 52/190 (27%), Positives = 78/190 (40%), Gaps = 19/190 (10%)
Query: 37 LDKLSKGGFRFTGFHTASACSPTRSMLLSGTDNHLAGLGQMAEYARQFPEKFKDKPGYEG 96
+D+L+ G + ++ C+P+RS LL+G GL + +P
Sbjct: 1 MDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGL-----------QHSIIRPQQPN 49
Query: 97 YLNYKVAALPEILSPE-YYTLISGKWHLGL-EKPYWPSDRGFQKRFTLLPGAGNHFKC-N 153
L LP+ L Y T + GKWHLG K P+ RGF L G +++ N
Sbjct: 50 CLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDN 109
Query: 154 LDSKFLLPWIYQENGERVDHNKFPENFYSTTYFTDKFLEYLKDDEERKGRPFFGQLTYTA 213
D + + E GE V + YST + + L + RP F + + A
Sbjct: 110 CDGPGVCGFDLHE-GENVAWGLSGQ--YSTMLYAQRASHILASHSPQ--RPLFLYVAFQA 164
Query: 214 PHWPLQAPAE 223
H PLQ+P E
Sbjct: 165 VHTPLQSPRE 174
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.139 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,582,234
Number of Sequences: 60738
Number of extensions: 1884506
Number of successful extensions: 3675
Number of sequences better than 1.0e-05: 20
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3594
Number of HSP's gapped (non-prelim): 55
length of query: 555
length of database: 30,389,216
effective HSP length: 111
effective length of query: 444
effective length of database: 23,647,298
effective search space: 10499400312
effective search space used: 10499400312
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)