ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0866 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0866 294261 295814 518
(518 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOL119c [G] KOG2504 Monocarboxylate transporter 338 9e-93
YOR306c [G] KOG2504 Monocarboxylate transporter 318 1e-86
YNL125c [G] KOG2504 Monocarboxylate transporter 100 9e-21
7299667 [G] KOG2504 Monocarboxylate transporter 91 3e-18
Hs20559959 [G] KOG2504 Monocarboxylate transporter 77 5e-14
Hs18699730 [G] KOG2504 Monocarboxylate transporter 77 5e-14
YKL221w [G] KOG2504 Monocarboxylate transporter 76 1e-13
CE04864 [G] KOG2504 Monocarboxylate transporter 75 2e-13
7290288 [G] KOG2504 Monocarboxylate transporter 74 4e-13
Hs4759116 [G] KOG2504 Monocarboxylate transporter 74 7e-13
CE05457 [G] KOG2504 Monocarboxylate transporter 74 7e-13
Hs19923753 [G] KOG2504 Monocarboxylate transporter 73 9e-13
CE29573 [G] KOG2504 Monocarboxylate transporter 73 9e-13
7302291 [G] KOG2504 Monocarboxylate transporter 71 3e-12
7303562 [G] KOG2504 Monocarboxylate transporter 70 1e-11
Hs4759112 [G] KOG2504 Monocarboxylate transporter 69 2e-11
CE12336 [G] KOG2504 Monocarboxylate transporter 64 5e-10
Hs4759118 [G] KOG2504 Monocarboxylate transporter 63 9e-10
7303156 [G] KOG2504 Monocarboxylate transporter 62 2e-09
CE21446 [G] KOG2504 Monocarboxylate transporter 61 5e-09
CE20478 [G] KOG2504 Monocarboxylate transporter 61 5e-09
Hs5730045 [G] KOG2504 Monocarboxylate transporter 60 6e-09
CE02803 [G] KOG2504 Monocarboxylate transporter 60 8e-09
7292012 [G] KOG2504 Monocarboxylate transporter 60 1e-08
Hs4759120 [G] KOG2504 Monocarboxylate transporter 59 2e-08
Hs22064599 [G] KOG2504 Monocarboxylate transporter 59 2e-08
CE03442 [G] KOG2504 Monocarboxylate transporter 56 1e-07
7303213 [G] KOG2504 Monocarboxylate transporter 56 1e-07
7295764 [G] KOG2504 Monocarboxylate transporter 56 1e-07
7293575 [G] KOG2504 Monocarboxylate transporter 56 1e-07
7293576 [G] KOG2504 Monocarboxylate transporter 55 3e-07
Hs7019529 [G] KOG2504 Monocarboxylate transporter 53 1e-06
>YOL119c [G] KOG2504 Monocarboxylate transporter
Length = 501
Score = 338 bits (868), Expect = 9e-93
Identities = 176/451 (39%), Positives = 275/451 (60%), Gaps = 10/451 (2%)
Query: 44 EVGININELQPVQSFDNDDGGSDAYTDYDDDGFTYAEGGIAAWLVVLGSFLGILPTWGLY 103
+V +++N+L V S + +A YDDD + +GG+ AWLVV G+F+G++P +GL
Sbjct: 58 QVDLDVNKLTNVTSRVLNT--PEASLIYDDDR-EFPDGGLKAWLVVFGAFMGLVPVFGLI 114
Query: 104 FSAGVIQTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVM 163
S G I++Y+++HQL + S+ST+SWIFS+ + + + SG YFDR G+ + GTV+
Sbjct: 115 NSLGAIESYISKHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVI 174
Query: 164 TVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGS 223
GG+ A+A C VWQFILA SVC G G+GI +PL+G + F KRR IAT+++ GGS
Sbjct: 175 YAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGS 234
Query: 224 IGGVIFPLFLEKSFKNLGFAWTMRIMALICGVCLTVSMFLIKEDPEKRAAVEPKDASTPF 283
IGG++FP+ L K +K +GF W +RI++ IC CL + L +E + V+P +
Sbjct: 235 IGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASVLARE--RTKPVVQPFKSKAEV 292
Query: 284 HKNLLYNIRDSFDYKSIVSDQKYLFCVLASCLAEVSTGAVLTYITSYCTTVGYSENTSFL 343
K + I F+++ + + K+LF + + AE S + TY+ SY T G +EN ++
Sbjct: 293 AK---WYISSVFNWRYFL-EGKFLFVAIGASFAESSLTSCATYLASYSMTRGNTENVAYT 348
Query: 344 LVTILNTLSIVGGYMFSFLADKVMGRFNVMIMINFLLGFVPLIFWLPFGNIGPSVMYGFS 403
++T N + I+G Y+ + ADK +GRFNV I+ + + WLPFG V++ +
Sbjct: 349 MITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFVMWLPFGG-NTKVLWAYV 407
Query: 404 AVYGLFYGSLINLAPVCCGQISRTNEFGRRYATMYCFVGLSFLVAIPVSGVIIGDGSLKN 463
++G GS+++L PVC GQIS+T +FG+RYAT+Y L + +P+ G +IG G++ N
Sbjct: 408 CLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGGTLIGKGTVAN 467
Query: 464 YNNFIIYVSVLSMISSGLYTMSKCYAVKQKL 494
YN+FII+ S L + Y +S+ V KL
Sbjct: 468 YNHFIIFNSALMAAGAACYIISRHICVGAKL 498
>YOR306c [G] KOG2504 Monocarboxylate transporter
Length = 521
Score = 318 bits (815), Expect = 1e-86
Identities = 174/433 (40%), Positives = 252/433 (58%), Gaps = 11/433 (2%)
Query: 65 SDAYTDYDDDGFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTS 124
SD D +++ ++ EGG AW+V G FLG++ +GL S GVI++++ +QL ES S
Sbjct: 86 SDKEEDSNEEIESFPEGGFKAWVVTFGCFLGLIACFGLLNSTGVIESHLQDNQLSSESVS 145
Query: 125 TVSWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILAL 184
T+ W+FS+ + + + SG YFDR G R +++GTV V G+ A A TK W FIL+
Sbjct: 146 TIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSF 205
Query: 185 SVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFK------ 238
++ G G+GI SPL+ H+F KRR A A+A GGS+GGV+FP+ L F
Sbjct: 206 AIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSDTD 265
Query: 239 -NLGFAWTMRIMALICGVCLTVSMFLIKEDPEKRAAVEPKDASTPFHKNLLYNIRDSFDY 297
GF W +R + + LT+S+ L+KE KD + + L I FD
Sbjct: 266 PTYGFVWGIRTLGFLDLALLTLSIILVKE-RLPHVIENSKDGESRWRYILRVYILQCFDA 324
Query: 298 KSIVSDQKYLFCVLASCLAEVSTGAVLTYITSYCTTVGYSENTSFLLVTILNTLSIVGGY 357
K+ + D KYLFCVL + +E+S + LTY SY T+ G S N ++ L+ I+N I G +
Sbjct: 325 KAFL-DMKYLFCVLGTVFSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRW 383
Query: 358 MFSFLADKVMGRFNVMIMINFLLGFVPLIFWLPFGNIGPSVMYGFSAVYGLFYGSLINLA 417
+ +L+DK GRFNV I L V + WLPFG + MY SA+YG GS+ +L
Sbjct: 384 VPGYLSDK-FGRFNVAIATLLTLFIVMFVGWLPFGT-NLTNMYVISALYGFCSGSVFSLL 441
Query: 418 PVCCGQISRTNEFGRRYATMYCFVGLSFLVAIPVSGVIIGDGSLKNYNNFIIYVSVLSMI 477
PVCCGQIS+T EFG+RY+TMY VG LV IP++G II + +Y ++II+ + + +
Sbjct: 442 PVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIKTTADYQHYIIFSGLATFV 501
Query: 478 SSGLYTMSKCYAV 490
S+ Y +S+ Y V
Sbjct: 502 SAVCYIISRAYCV 514
>YNL125c [G] KOG2504 Monocarboxylate transporter
Length = 673
Score = 99.8 bits (247), Expect = 9e-21
Identities = 100/455 (21%), Positives = 175/455 (37%), Gaps = 28/455 (6%)
Query: 51 ELQPVQSFDNDDGG-SDAYTDYDDDGFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVI 109
E Q + F+ D+ +T+ G W+V FL + TWG S GV
Sbjct: 177 EAQGITEFEPDEPTVKKVFTNKSTGQLELPPDGGYGWVVTFCVFLTMFSTWGCNASFGVD 236
Query: 110 QTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFSGMYFDRY--------GARKPLVIGT 161
Y H T L+ G +VF G G R ++ G
Sbjct: 237 LAYYLNHD-------TYPGASKYDYALIAGLTVFLGQLLSPLVMALMRIIGLRTTMLFGD 289
Query: 162 VMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAING 221
+ + L + TK+WQ + VG + P + F K+RA+A V++ G
Sbjct: 290 AVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLG 349
Query: 222 GSIGGVIFPLFLEKSFKNLG-FAWTMRIMALICGVCLTVSMFLIKEDPEKRAAVEPKDAS 280
GGV++ L K + G W +RI+ + C + + V++ L+KE A+ K
Sbjct: 350 TGAGGVVYGLATNKMLSDFGNTRWCLRIIGISCSISVLVAIALLKE-RNPTPAIGLKSPR 408
Query: 281 TPFHKNLLYNIRDSFDYKSIVSDQKYLFCVLASCLAEVSTGAVLTYITSYCTTVGYSENT 340
F + ++ F K +++ + L A + ++ ++SY + G S +
Sbjct: 409 AMFEQ-----LKAMFSLK-VITKPFVVLIALWFMFALFAYNMMVFTLSSYAISKGLSSHD 462
Query: 341 SFLLVTILNTLSIVGGYMFSFLADKVMGRFNVMIMINFLLGFVPLIFWLPFGNIGPSVMY 400
+ L ILN +G + DK GR NV I++ LL FW+P +
Sbjct: 463 ASTLTAILNGSQSIGRPLMGLAGDK-FGRANVTIVLTTLLTIYMFAFWIPAHTFVQLIF- 520
Query: 401 GFSAVYGLFYGSLINLAPVCCGQISRTNEFGRRYATM-YCFVGLSFLVAIPVSGVIIGDG 459
FS + G G + V + + EF +A + YC + + + +
Sbjct: 521 -FSILVGSCVGVANVMNTVLIADMVKPEEFLPAWAFVNYCGAPFLLVCEVIAQALTVEKD 579
Query: 460 SLKNYNNFIIYVSVLSMISSGLYTMSKCYAVKQKL 494
Y + I+ + + L ++ + Y+++ KL
Sbjct: 580 KSNPYLHAQIFCGCCFIAALILISILREYSIRMKL 614
>7299667 [G] KOG2504 Monocarboxylate transporter
Length = 571
Score = 91.3 bits (225), Expect = 3e-18
Identities = 118/471 (25%), Positives = 197/471 (41%), Gaps = 55/471 (11%)
Query: 54 PVQSFDNDDGGS--DAYTDYDDDGFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQT 111
PVQ+ + + G+ +A D G +GG AWLV++ +FL G+ F G I T
Sbjct: 6 PVQNGNGNANGTHIEAPCCRDIHGKEPPDGGARAWLVMVSAFL----CNGIIF--GFINT 59
Query: 112 YVARHQLKDESTSTVSWIFSVSSCLLLGT---------SVFSGMYFDRYGARKPLVIGTV 162
Y H L + + + + S L+G S +G D+ G R G V
Sbjct: 60 YGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGV 119
Query: 163 MTVGGVLAVAQCTK-VWQFILALSVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAING 221
++ GG+L + CT+ + + G G+ + +P L + H+F++ + G
Sbjct: 120 LSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAG 179
Query: 222 GSIGGVIFPLFLEKSFKNLGFAWTMRIMALICGVCLTVSMFLIKEDPEKRAAVEPKDAST 281
S+ VI P L+K + G T+RIM+L+ + S F+ K P PK
Sbjct: 180 SSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCS-FVYK--PLHPPPEPPKKKPG 236
Query: 282 PFHKNLLYNIRDSFDYKSIVSDQ---KYLFCVLASCLAEVSTGAVLTYI--TSYCTTVGY 336
NL +SI++ + + F + A C+ G + Y+ + T
Sbjct: 237 RSRINLF--------LRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFP 288
Query: 337 SENTSFLLVTILNTLSIVGGYMFSFLADKV-MGRFNVMIMINFLLGFVPLIFWLPFGNIG 395
E+ + L V + S +G +F +AD + R + + +G V L+ LP N
Sbjct: 289 GEDVN-LPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLL--LPLTN-S 344
Query: 396 PSVMYGFSAVYGLFYGSLIN-LAPVC---CGQISRTNEFGRRYATMYCFVGLSFL---VA 448
++ F+ V GLF G I+ L P+ CG T G +GLS + V
Sbjct: 345 YVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIG-------FLLGLSSIPLTVG 397
Query: 449 IPVSGVIIGDGSLKNYNNFIIYVSVLSMISSGLYTMSKCYAVKQKLNRSPR 499
PV+G+I S +Y +I + ++ S L + KC ++ +PR
Sbjct: 398 PPVAGMIF--DSTNSYTLPLILAGLPPLLGSSLLFLIKCVKEEENGVSAPR 446
>Hs20559959 [G] KOG2504 Monocarboxylate transporter
Length = 426
Score = 77.4 bits (189), Expect = 5e-14
Identities = 90/410 (21%), Positives = 168/410 (40%), Gaps = 50/410 (12%)
Query: 86 WLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFSG 145
W+VVL +F +G+ S GV +V +E + VSWI S+ + S
Sbjct: 14 WVVVLSAFFQSALVFGVLRSFGVF--FVEFVAAFEEQAARVSWIASIGIAVQQFGSPVGS 71
Query: 146 MYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGCICH 205
++G R ++ G ++ G+L + T + L++ + G+G +T +P L C+
Sbjct: 72 ALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTLACLSC 131
Query: 206 HFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAW--------TMRIMALICGVCL 257
+F +RR++AT +A+ G + F F + + +AW + + + CG L
Sbjct: 132 YFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSH--YAWRGSLLLVSALSLHLVACGALL 189
Query: 258 TVSMFLIKEDPEKRAAVEPKDASTPFHKNLLYNIRDSFDYKSIVSDQKYLFCVLASCLAE 317
+ EDP A P+ T S++ +L +A L
Sbjct: 190 RPPS--LAEDP---AVGGPRAQLT-----------------SLLHHGPFLRYTVA--LTL 225
Query: 318 VSTGAVLTY--ITSYCTTVGYSENTSFLLVTILNTLSIVGGYMFSFLADKVMGRFNVMIM 375
++TG + Y + ++ + + + L++++ +VG + +L D V G ++M
Sbjct: 226 INTGYFIPYLHLVAHLQDLDWDPLPAAFLLSVVAISDLVGRVVSGWLGDAVPGPVTRLLM 285
Query: 376 INFLLGFVPLIFWLPFGNIGPSVMYGFSAVYGLFYGSLINLAPVCCGQISRTNEFGRRYA 435
+ L V L + P P+ + + YG G+L LA ++ T
Sbjct: 286 LWTTLTGVSLALF-PVAQ-APTALVALAVAYGFTSGALAPLAFSVLPELIGTRR------ 337
Query: 436 TMYCFVGLSFLVAIPVSGVIIGDGSLKNYNNFIIYVSVLSMISSGLYTMS 485
+YC GL L I G ++G L Y + S + +G + +S
Sbjct: 338 -IYC--GLGLLQMIESIGGLLGP-PLSGYLRDVTGNYTASFVVAGAFLLS 383
>Hs18699730 [G] KOG2504 Monocarboxylate transporter
Length = 515
Score = 77.4 bits (189), Expect = 5e-14
Identities = 77/391 (19%), Positives = 164/391 (41%), Gaps = 30/391 (7%)
Query: 80 EGGIAAWLVVL------GSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVS 133
EGG WLV+L GS GI G+ F +++T+ ++ D+ +W+ S+S
Sbjct: 66 EGGWG-WLVMLAAMWCNGSVFGIQNACGVLF-VSMLETFGSKDD--DKMVFKTAWVGSLS 121
Query: 134 SCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSG 193
++ ++ D +G RK V+G + G+++ + + + L + G
Sbjct: 122 MGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCS 181
Query: 194 ITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALIC 253
P L + H+F+KR + + G S+ ++ PL L ++G +T+R++
Sbjct: 182 FAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVL---- 237
Query: 254 GVCLTVSMFLIKEDPEKRAAVEPKDASTPFHKNLLYNIRDSFDYKSIVSDQKYLFCVLAS 313
C+ + + + + A KD + + L++ + K I + +F V A
Sbjct: 238 --CIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFA--IFKVTAY 293
Query: 314 CLAEVSTG-AVLTYITSYCTTVGY------SENTSFLLVTILNTLSIVGGYMFSFLADKV 366
+ V A+ Y Y + + E +++ + S VG +F +AD V
Sbjct: 294 AVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYV 353
Query: 367 MG--RFNVMIMINFLLGFVPLIFWLPFGNIGPSVMYGFSAVYGLFYGSLINLAPVCCGQI 424
G + + ++ F +G + ++ +P +I + + GLF G I++ ++
Sbjct: 354 PGVKKVYLQVLSFFFIGLMSMM--IPLCSIF-GALIAVCLIMGLFDGCFISIMAPIAFEL 410
Query: 425 SRTNEFGRRYATMYCFVGLSFLVAIPVSGVI 455
+ + + F+ + V P++G++
Sbjct: 411 VGAQDVSQAIGFLLGFMSIPMTVGPPIAGLL 441
>YKL221w [G] KOG2504 Monocarboxylate transporter
Length = 473
Score = 75.9 bits (185), Expect = 1e-13
Identities = 85/469 (18%), Positives = 185/469 (39%), Gaps = 53/469 (11%)
Query: 59 DNDDGGSDAYTDYDDDGFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQL 118
D+ +G + + D G+ W ++L L TWG + Y+A H L
Sbjct: 23 DDINGNTSISIEVPDGGY--------GWFILLAFILYNFSTWGANSGYAI---YLA-HYL 70
Query: 119 KDESTSTVSWIFSVS------SCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVA 172
++ + + S + S SC L V + +Y + + + +G + +L A
Sbjct: 71 ENNTFAGGSKLDYASIGGLAFSCGLFFAPVITWLYHI-FSIQFIIGLGILFQGAALLLAA 129
Query: 173 QCTKVWQFILALSVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLF 232
+W+ L V +G G P + I F+ +R++A+ + G +GG++F L
Sbjct: 130 FSVTLWEIYLTQGVLIGFGLAFIFIPSVTLIPLWFRNKRSLASGIGTAGSGLGGIVFNLG 189
Query: 233 LEKSFKNLGFAWTMRIMALICGVCLTVSMFLIKEDPEKRAAVEPKDASTPFHKNLLYNIR 292
++ + G W + +IC T+++ L + H+ L + R
Sbjct: 190 MQSILQKRGVKWALIAQCIICTSLSTIALMLTRTT----------------HQGLRQHKR 233
Query: 293 ----DSFDYKSIVSDQKYLFCVLASCLAEVSTGAVLTYITSYCTTVGYSENTSFLLVTIL 348
+ DY + + +L S A + +L ++ + ++GY+ + ++
Sbjct: 234 SYKFELLDYDVLSNFAVWLLFGFVS-FAMLGYVVLLYSLSDFTVSLGYTSKQGSYVSCMV 292
Query: 349 NTLSIVGGYMFSFLADKVMGRFNVMIMINFLLGFVPLIFWLPFGNIGPSVMYGF--SAVY 406
+ S++G + +ADK G V ++++ ++ + W+P N+ ++ +G ++
Sbjct: 293 SVGSLLGRPIVGHIADK-YGSLTVGMILHLVMAILCWAMWIPCKNLATAIRFGLLVGSIM 351
Query: 407 GLFYGSLINLAPVCCGQISRTNEFGRRYATMYCFVGLSFLVAIPVSGVIIGDGSLKNYNN 466
G + ++ ++ G FG + M F ++ ++ + + D + +Y
Sbjct: 352 GTIWPTIASIVTRIVGLQKLPGTFGSTWIFMAAFALVAPIIGLELRST---DTNGNDYYR 408
Query: 467 FIIY-------VSVLSMISSGLYTMSKCYAVKQKLNRSPRNAHNNTILS 508
I+ VS+ + G AV++ + H N LS
Sbjct: 409 TAIFVGFAYFGVSLCQWLLRGFIIARDEIAVREAYSADQNELHLNVKLS 457
>CE04864 [G] KOG2504 Monocarboxylate transporter
Length = 556
Score = 75.5 bits (184), Expect = 2e-13
Identities = 40/145 (27%), Positives = 77/145 (52%), Gaps = 4/145 (2%)
Query: 86 WLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTV-SWIFSVSSCLLLGTSVFS 144
W+VV+GSF + G +S G++ + ++ S +T+ S I S+ + LG +
Sbjct: 21 WVVVIGSFFIHVFADGFVYSFGIL---AEKLMIEFNSNNTMTSLIVSMLTGFTLGAGPLA 77
Query: 145 GMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGCIC 204
++YG R +IG + G L T++W F++++ V +G G G+ P + +
Sbjct: 78 SAVCNKYGCRITTIIGAGVAFVGCLLSCFATEIWHFVISVGVIMGIGFGLVYCPAIVIVT 137
Query: 205 HHFQKRRAIATAVAINGGSIGGVIF 229
+F+ +R++AT +A+ G +G V+F
Sbjct: 138 MYFESKRSLATGIAVAGAGVGAVVF 162
>7290288 [G] KOG2504 Monocarboxylate transporter
Length = 715
Score = 74.3 bits (181), Expect = 4e-13
Identities = 47/197 (23%), Positives = 83/197 (41%), Gaps = 2/197 (1%)
Query: 86 WLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFSG 145
W+VV GSF+ + T G+ +S G+ Y +E +WI S+ + + S
Sbjct: 124 WVVVFGSFMIHIVTDGMTYSFGIF--YNEFLDYFNEGKGYTAWIASIMVGVTFSSGPISS 181
Query: 146 MYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGCICH 205
+ +RYG R + G+++ ++ V I+ + G G G+ P + +
Sbjct: 182 SFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQ 241
Query: 206 HFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALICGVCLTVSMFLIK 265
+F+ +R++AT +A+ G G +F E N G+ M I+ I C+
Sbjct: 242 YFEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRP 301
Query: 266 EDPEKRAAVEPKDASTP 282
+ E P STP
Sbjct: 302 LELEAPPQTPPNTPSTP 318
>Hs4759116 [G] KOG2504 Monocarboxylate transporter
Length = 505
Score = 73.6 bits (179), Expect = 7e-13
Identities = 88/431 (20%), Positives = 172/431 (39%), Gaps = 37/431 (8%)
Query: 82 GIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVSSCLLLGTS 141
G AW+V+L + + T G G+ T + S S SW S+ + +L
Sbjct: 10 GSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEF--QASNSETSWFPSILTAVLHMAG 67
Query: 142 VFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLG 201
+ R+G R +++G V+ G++A + + Q G G + +
Sbjct: 68 PLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSIT 127
Query: 202 CICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMA---LICGVCLT 258
+ +F +RR +A A+A G S+G ++PL +NLG+ T + L C +C
Sbjct: 128 VLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGA 187
Query: 259 VSMFLIKEDPEKRAAVEPKDASTPFHKNLL---YNIRDSFDYKSIVSDQKYLFCVLASCL 315
+ + + P TP L I+ + + + Y +L
Sbjct: 188 IIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCVYILGVMW 247
Query: 316 AEVSTGAVLTYITSYCTTVGYSENTSFLLVTILNTLSIVGGYMFSFLADKVMGR------ 369
+ + ++ Y E + LL++I+ +I LA + GR
Sbjct: 248 SVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNI----FLRPLAGLMAGRPAFASH 303
Query: 370 ----FNVMIMINFLLGFVPLI---FWLPFGNIGPSVMYGFSAVYGLFYGSLINLAPVCCG 422
F++ +++N L V FW+ G + S + L + L+++ P+
Sbjct: 304 RKYLFSLALLLNGLTNLVCAASGDFWVLVGYC-LAYSVSMSGIGALIFQVLMDIVPM--- 359
Query: 423 QISRTNEFGRRYATMYCFVGLSFLVAIPVSGVIIGDGSLKNYNNFIIYVSVLSMISSGLY 482
++F R GL+FL++ P++G+++ N +++ Y+S +IS+ L+
Sbjct: 360 -----DQFPRALGLFTVLDGLAFLISPPLAGLLL---DATNNFSYVFYMSSFFLISAALF 411
Query: 483 TMSKCYAVKQK 493
YA+++K
Sbjct: 412 MGGSFYALQKK 422
>CE05457 [G] KOG2504 Monocarboxylate transporter
Length = 807
Score = 73.6 bits (179), Expect = 7e-13
Identities = 55/194 (28%), Positives = 98/194 (50%), Gaps = 9/194 (4%)
Query: 78 YAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVSSCLL 137
Y +GG WLVVL SFL G F G++ + H S ++ +S L+
Sbjct: 102 YKDGGYG-WLVVLASFLMHAVCDGASFCFGIVFVKIQEHFQCGRFVSMITASMFLSLPLI 160
Query: 138 LGTSVFSGMYFDRYGARKPLVIG-TVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITS 196
+ S +G+ D G R ++IG ++ TV ++A+ C+ ++ F+++ + G G
Sbjct: 161 M--SPVAGIVSDILGCRMSIIIGASICTVSCIIAMF-CSHIFFFMISFGLGCGVGMSFIY 217
Query: 197 SPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNL-GFAWTMRIMALICGV 255
+ + + ++F+KRR +AT+ A++G +G VI+P+ L S L F +RI+ + V
Sbjct: 218 NAAIVIVTYYFEKRRGLATSFAVSGTGVGTVIYPILLNLSMIYLASFVSDIRIILIFFAV 277
Query: 256 ---CLTVSMFLIKE 266
+ V F IK+
Sbjct: 278 MYFVIAVIGFFIKD 291
>Hs19923753 [G] KOG2504 Monocarboxylate transporter
Length = 500
Score = 73.2 bits (178), Expect = 9e-13
Identities = 66/305 (21%), Positives = 127/305 (41%), Gaps = 28/305 (9%)
Query: 75 GFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVSS 134
G+T +GG W VV+G+F+ I + F + + + +TS VSWI S+
Sbjct: 10 GYTPPDGGWG-WAVVIGAFISI--GFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIML 66
Query: 135 CLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGI 194
++ G S + ++YG+R +++G ++ G++A + C V Q + + V G G
Sbjct: 67 AVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAF 126
Query: 195 TSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALICG 254
+P L I +F KRR +A +A+ G + + F G+ + I+ +
Sbjct: 127 NLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLL 186
Query: 255 VCLTVSMFLIKEDPEKRAAVEPK------------------DASTPF-------HKNLLY 289
C + P+ A + K DA+T K ++
Sbjct: 187 NCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVF 246
Query: 290 NIRDSFDYKSIVSDQKYLFCVLASCLAEVSTGAVLTYITSYCTTVGYSENTSFLLVTILN 349
+ F ++ + + +L + + + A L +++SY + YS S L++IL
Sbjct: 247 QTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILA 306
Query: 350 TLSIV 354
+ +V
Sbjct: 307 FVDMV 311
>CE29573 [G] KOG2504 Monocarboxylate transporter
Length = 594
Score = 73.2 bits (178), Expect = 9e-13
Identities = 49/200 (24%), Positives = 89/200 (44%), Gaps = 10/200 (5%)
Query: 86 WLVVLGSFLGILPTWGLYFSAGV-IQTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFS 144
W+VVLGSF + G +S GV ++T + S + + I S+ + L LG+ +
Sbjct: 24 WVVVLGSFFVHVFADGFVYSFGVLVETLMEEFHA---SNTMAALIISLLTGLTLGSGPLA 80
Query: 145 GMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGCIC 204
++YG R + G + G T +W ++ + V +GTG G+ P + +
Sbjct: 81 SAVCNKYGCRITTITGAGVAFVGCALSYFATAMWHIVITVGVIMGTGFGLMYCPAIVIVT 140
Query: 205 HHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWT------MRIMALICGVCLT 258
+F+ +R++AT +A+ G +G V+F N G+ + ++ +CG
Sbjct: 141 MYFENKRSLATGIAVAGAGVGTVLFAPINAFFINNYGWRSVFLAFLFILVLCALCGATFA 200
Query: 259 VSMFLIKEDPEKRAAVEPKD 278
F + D E+ E D
Sbjct: 201 PLEFALVPDEEEEVNDEVLD 220
>7302291 [G] KOG2504 Monocarboxylate transporter
Length = 800
Score = 71.2 bits (173), Expect = 3e-12
Identities = 65/251 (25%), Positives = 109/251 (42%), Gaps = 30/251 (11%)
Query: 25 TIELKGINEQRTRKNVIGSEVGININELQPVQSFDNDDGGSDAYTDYDDDGFTYAEGGIA 84
T + G + + RK +I +E G +I D ++ T DG
Sbjct: 2 TCLMNGNGQVKRRKRLISNESGDSI-----------DSSSTEKKTPKMPDGGY------- 43
Query: 85 AWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSV--SSCLLLGTSV 142
W+VV S + L GL FS G+I + + ESTS +WI S+ S LL+G +
Sbjct: 44 GWVVVFASLVVSLIADGLSFSFGLINVELLEYF--GESTSKTAWISSLFFSVPLLMGP-I 100
Query: 143 FSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGC 202
+S + D+YG RK ++G V++ G + C + ++ + G G GI +
Sbjct: 101 WSNLV-DKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVS 159
Query: 203 ICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIM------ALICGVC 256
I F K+R AT + +G IG ++ ++ G+ I+ A +CG
Sbjct: 160 IAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGAL 219
Query: 257 LTVSMFLIKED 267
+ +LI+E+
Sbjct: 220 MRDPDWLIEEN 230
>7303562 [G] KOG2504 Monocarboxylate transporter
Length = 596
Score = 69.7 bits (169), Expect = 1e-11
Identities = 38/143 (26%), Positives = 74/143 (51%), Gaps = 2/143 (1%)
Query: 122 STSTV-SWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQF 180
ST+TV SWI ++ S L L + S R+ R + +G + G++ T +
Sbjct: 7 STATVASWIPAILSALCLVLAPLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHL 66
Query: 181 ILALSVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNL 240
+L V G G G++++P + + +F K RA+A + ++G + G I P+ ++ +N
Sbjct: 67 LLTFGVLTGIGGGLSTTPGIVIVSQYFDKHRALANGICVSGTAAGSFILPVLIKHLAENC 126
Query: 241 GFAWTMRIM-ALICGVCLTVSMF 262
GF T+ I+ + VC++ +++
Sbjct: 127 GFHGTILILGGCMLHVCVSATLY 149
Score = 51.2 bits (121), Expect = 4e-06
Identities = 39/159 (24%), Positives = 73/159 (45%), Gaps = 6/159 (3%)
Query: 299 SIVSDQKYLFCVLASCLAEVSTGAVLTYITSYCTTVGYSENTSFLLVTILNTLSIVGGYM 358
S++ D ++ L+ L V +L Y+ ++ ++GY+++ + LV I L ++G
Sbjct: 392 SLLQDPSFILMCLSVTLMSVGCPYMLYYLPAHVISIGYNKSEAGYLVAISAVLDLIGRLG 451
Query: 359 FSFLAD-KVMGRFNVMIMINFLLGFVPLIFWLPFGNIGPSVMYGFS-AVYGLFYGSLINL 416
+L D ++ R + +LG + +PF V+ G S AVYGL GS L
Sbjct: 452 LGWLCDLQLFDRKKTYTLC--ILGAGCAVLTIPFAK--TLVLVGLSAAVYGLCLGSWYVL 507
Query: 417 APVCCGQISRTNEFGRRYATMYCFVGLSFLVAIPVSGVI 455
PV + T+ Y + F + + P++G++
Sbjct: 508 MPVLLADVFGTDRISSSYGLVRMFQSIGAISVPPLAGLM 546
>Hs4759112 [G] KOG2504 Monocarboxylate transporter
Length = 465
Score = 68.6 bits (166), Expect = 2e-11
Identities = 93/436 (21%), Positives = 171/436 (38%), Gaps = 35/436 (8%)
Query: 67 AYTDYDDDGFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTV 126
A D G +GG W V+ G F ++ + F V + Q S
Sbjct: 4 AVVDEGPTGVKAPDGGWG-WAVLFGCF--VITGFSYAFPKAVSVFFKELIQEFGIGYSDT 60
Query: 127 SWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSV 186
+WI S+ +L GT + +R+G R +++G + G++A + C + Q L V
Sbjct: 61 AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV 120
Query: 187 CVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGSIG-GVIFPL--FLEKSFKNLGFA 243
G G + P L + +F KRR +A +A G + + PL L+ + G
Sbjct: 121 ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF 180
Query: 244 WTMRIMALICGVCLTVSMFLIKEDPEKRAAVEPKDASTPFHKNLLYNIRDSFDYKSIVSD 303
+ + L C VC + L+ +P + LL S+ D
Sbjct: 181 LILGGLLLNCCVCAALMRPLV-------VTAQPGSGPPRPSRRLL--------DLSVFRD 225
Query: 304 QKYLFCVLASCLAEVSTGAVLTYITSYCTTVGYSENTSFLLVTILNTLSIVGGYMFSFLA 363
+ ++ +A+ + + ++ SY +G + + L+TIL + I F+A
Sbjct: 226 RGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVA 285
Query: 364 DKVMGRFNVMIMINFLLGFVPL--IFWLPFGNIGPSVMYGFSAVYGLFYGSLINLAPVCC 421
R + + +F + F L + G+ G V+ F +G+ YG + L
Sbjct: 286 GLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVV--FCIFFGISYGMVGALQFEVL 343
Query: 422 GQISRTNEFGRRYATMYCFVGLSFLVAIPVSGVIIGDGSLKNYNNFIIYVSVLS----MI 477
I T++F + ++ LV P SG G L + + +YV +L+ +
Sbjct: 344 MAIVGTHKFSSAIGLVLLMEAVAVLVG-PPSG-----GKLLDATHVYMYVFILAGAEVLT 397
Query: 478 SSGLYTMSKCYAVKQK 493
SS + + + +++K
Sbjct: 398 SSLILLLGNFFCIRKK 413
>CE12336 [G] KOG2504 Monocarboxylate transporter
Length = 596
Score = 63.9 bits (154), Expect = 5e-10
Identities = 41/175 (23%), Positives = 75/175 (42%), Gaps = 1/175 (0%)
Query: 70 DYDDDGFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWI 129
+ +D GF G W +V SFL + G+ F+ G I H S +
Sbjct: 24 ELEDAGFIAPPDGGYGWAIVAASFLLNMIVDGVIFTVGKILQPAWVHSFGISEASAAMTM 83
Query: 130 FSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVG 189
+S C + S + + +G R+ + G+++ G L ++ ++ + G
Sbjct: 84 SILSGCYFFAGPIAS-VLCNVFGCRQVALAGSLIAALGFLLSISAPNIYVLYVSFGLIAG 142
Query: 190 TGSGITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAW 244
G G+ P + I +F K+R++AT +A+ G IG +F L + + +G W
Sbjct: 143 AGFGMMYLPAIVIISQYFAKKRSVATGIAVCGSGIGTTVFALLNDVVWDFVGGDW 197
>Hs4759118 [G] KOG2504 Monocarboxylate transporter
Length = 523
Score = 63.2 bits (152), Expect = 9e-10
Identities = 43/188 (22%), Positives = 99/188 (51%), Gaps = 10/188 (5%)
Query: 65 SDAYTDYDDDGFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTS 124
++ YT+ D G+ +A ++ + V + ++ GI+ T+G++F+ ++ ++ +ES S
Sbjct: 12 ANVYTEVPDGGWGWAVA-VSFFFVEVFTY-GIIKTFGVFFN-DLMDSF-------NESNS 61
Query: 125 TVSWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILAL 184
+SWI S+ +L ++ + + +R+G R +++G ++ G++A + +V +A+
Sbjct: 62 RISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAI 121
Query: 185 SVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAW 244
+ G G + P + + +F KRR+I TAVA G F + + +G+ +
Sbjct: 122 GIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRY 181
Query: 245 TMRIMALI 252
++ + L+
Sbjct: 182 SLLFVGLL 189
>7303156 [G] KOG2504 Monocarboxylate transporter
Length = 835
Score = 62.0 bits (149), Expect = 2e-09
Identities = 54/186 (29%), Positives = 86/186 (46%), Gaps = 15/186 (8%)
Query: 56 QSFDNDDGGSDAYTDYDDDGFTYAEG-----------GIAAWLVVLGSFLGILPTWGLYF 104
QSFD + S D+ G G G W++++ SFL L GL F
Sbjct: 264 QSFDMESKNSKESFDFSRGGRRLGSGMVFIYMVIPPDGGFGWVIMVLSFLAQLIIDGLIF 323
Query: 105 SAGVIQTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMT 164
+ GV+ +A Q D S S+VS++ SV + FS + +R+G RK + G + +
Sbjct: 324 TIGVLLPSIA--QDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCS 381
Query: 165 VGGVLAVAQCTKVWQFILALSVCVG-TGSGITSSPLLGCICHHFQKRRAIATAVAINGGS 223
+LA + + I SV G T S I +S L + ++F++ R +A + +GG
Sbjct: 382 AVSILASSWSVSLTMLIFFYSVLGGITLSMIWASSQL-IVGYYFERYRPMANGFSCSGGG 440
Query: 224 IGGVIF 229
G V+F
Sbjct: 441 AGIVLF 446
>CE21446 [G] KOG2504 Monocarboxylate transporter
Length = 666
Score = 60.8 bits (146), Expect = 5e-09
Identities = 48/195 (24%), Positives = 85/195 (42%), Gaps = 6/195 (3%)
Query: 77 TYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSV-SSC 135
T +GG W+VV SFL + G+ ++ G I + Q STS + S+ + C
Sbjct: 38 TPPDGGYG-WVVVAASFLVNMAVDGVIYTCGKILVPIWADQFG--STSVAGAVISILTGC 94
Query: 136 LLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGIT 195
L + S + + +G R + G+++ L + +W+ L V G G G
Sbjct: 95 YYLAGPLASS-FVNVFGIRSVAIAGSILATTAFLLSRFASTIWELYLLFGVLGGIGFGCM 153
Query: 196 SSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALICGV 255
P + + +F K+R++AT +A+ G IG ++F F G M + +
Sbjct: 154 YLPSIVILSTYFAKKRSVATGIAVCGSGIGTMVFSTINGPVFDYFG-KDVGSFMVYLAAI 212
Query: 256 CLTVSMFLIKEDPEK 270
++ S+F + P K
Sbjct: 213 AISGSLFSLLFAPLK 227
>CE20478 [G] KOG2504 Monocarboxylate transporter
Length = 571
Score = 60.8 bits (146), Expect = 5e-09
Identities = 48/195 (24%), Positives = 85/195 (42%), Gaps = 6/195 (3%)
Query: 77 TYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSV-SSC 135
T +GG W+VV SFL + G+ ++ G I + Q STS + S+ + C
Sbjct: 38 TPPDGGYG-WVVVAASFLVNMAVDGVIYTCGKILVPIWADQFG--STSVAGAVISILTGC 94
Query: 136 LLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGIT 195
L + S + + +G R + G+++ L + +W+ L V G G G
Sbjct: 95 YYLAGPLASS-FVNVFGIRSVAIAGSILATTAFLLSRFASTIWELYLLFGVLGGIGFGCM 153
Query: 196 SSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALICGV 255
P + + +F K+R++AT +A+ G IG ++F F G M + +
Sbjct: 154 YLPSIVILSTYFAKKRSVATGIAVCGSGIGTMVFSTINGPVFDYFG-KDVGSFMVYLAAI 212
Query: 256 CLTVSMFLIKEDPEK 270
++ S+F + P K
Sbjct: 213 AISGSLFSLLFAPLK 227
>Hs5730045 [G] KOG2504 Monocarboxylate transporter
Length = 613
Score = 60.5 bits (145), Expect = 6e-09
Identities = 66/388 (17%), Positives = 151/388 (38%), Gaps = 16/388 (4%)
Query: 75 GFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTST---VSWIFS 131
GF EGG W+VV + +G++ S G++ + + + K+++ +W+ +
Sbjct: 165 GFQPPEGGFG-WVVVFAATWCNGSIFGIHNSVGILYSMLLEEE-KEKNRQVEFQAAWVGA 222
Query: 132 VSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTG 191
++ ++ S ++ DR G R G + G+ + + + + G G
Sbjct: 223 LAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCG 282
Query: 192 SGITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMAL 251
P L + H+FQ+R +A V G SI + FP + + A T ++++
Sbjct: 283 CSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLST 342
Query: 252 ICGVCLTVSMFLIKEDPEKRAAVEPKDASTPFHKNLLYNIRDSFDYKSIVSDQKYLFCVL 311
V + +S+ P + + T H+ L +R F+ + + + Y
Sbjct: 343 FMFVLMLLSLTYRPLLPSSQDTPSKRGVRT-LHQRFLAQLRKYFNMR-VFRQRTYRIWAF 400
Query: 312 ASCLAEVSTGAVLTYITSYCTTVGYSENTSFLLVTILNTLSIVGGYMFSFLADKVMG--R 369
A + ++ Y +++L+ + S +G + ++D + G +
Sbjct: 401 GIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKK 460
Query: 370 FNVMIMINFLLGFVPLIFWL--PFGNIGPSVMYGFSAVYGLFYGSLINLAPVCCGQISRT 427
+ ++ LLG + ++ L FG + ++ GL G I + ++
Sbjct: 461 IYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLF-----LGLCDGFFITIMAPIAFELVGP 515
Query: 428 NEFGRRYATMYCFVGLSFLVAIPVSGVI 455
+ + + + L + P++G++
Sbjct: 516 MQASQAIGYLLGMMALPMIAGPPIAGLL 543
>CE02803 [G] KOG2504 Monocarboxylate transporter
Length = 808
Score = 60.1 bits (144), Expect = 8e-09
Identities = 42/180 (23%), Positives = 86/180 (47%), Gaps = 4/180 (2%)
Query: 79 AEGGIAAWLVVLGSFLGILPTWGLYFSAGVI-QTYVARHQLKDESTSTVSWIFSVSSCLL 137
A G W++V +F+ L G+ + Q+Y R+Q D T + + + + LL
Sbjct: 83 APDGGYGWVIVFAAFMSNLVVDGISTAFSEFKQSYKERYQESDGLTVFIGSLI-IGTYLL 141
Query: 138 LGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSS 197
+G V + ++Y R ++ G +++ + ++ F+L V G G G+
Sbjct: 142 VGPLVSA--LCNKYEQRYVVMAGGLISGIAFMIAPASPNIYVFMLIYGVMGGLGFGMIYL 199
Query: 198 PLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALICGVCL 257
P + + +F +RA+AT +++ G +G + PL + NLG+ T+ ++A++ C+
Sbjct: 200 PAIVVVGFYFDSKRAMATGISVAGSGVGTFLVPLICQVCIANLGWQKTIWVLAVMIFSCV 259
>7292012 [G] KOG2504 Monocarboxylate transporter
Length = 816
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/208 (22%), Positives = 88/208 (42%), Gaps = 12/208 (5%)
Query: 61 DDGGSDAYTDYDDDGFTYAE-----GGIAAWLVVLGSFLGILPTWGLYFSAGV-IQTYVA 114
D+ D D DD+ Y E G W++ SF+ + G+ ++ G+ ++ +VA
Sbjct: 48 DEDNQDNDEDDDDEESVYGELPPPPDGGYGWVICFASFMCNMIVDGIAYTFGIFLEEFVA 107
Query: 115 RHQLKDESTSTVSWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQC 174
E TV+W+ S+ S + L ++YG R + G+++ +
Sbjct: 108 YFH---EGKGTVAWVGSLLSGVYLSAGPIVSALANKYGCRAVCIAGSIIACIAFVLSTFS 164
Query: 175 TKVWQFILALSVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLE 234
T V + G G G+ P + + ++F+ +R++AT +A+ G G F
Sbjct: 165 TNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFETKRSLATGIAVCGSGFGTFAFAPLAT 224
Query: 235 KSFKNLGFAWTMRIMALICGVCLTVSMF 262
+ G+ + I A G+ L ++F
Sbjct: 225 YLLEEYGWKNALLIFA---GLILNCAIF 249
>Hs4759120 [G] KOG2504 Monocarboxylate transporter
Length = 478
Score = 58.9 bits (141), Expect = 2e-08
Identities = 62/339 (18%), Positives = 139/339 (40%), Gaps = 15/339 (4%)
Query: 86 WLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFSG 145
W+VV +F+ I + F V + Q+ + S ++WI S+ ++ S
Sbjct: 20 WIVVGAAFISI--GFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSS 77
Query: 146 MYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGCICH 205
+ ++YG+R ++ G ++ G++ + + V Q L + G G P L I
Sbjct: 78 VLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGK 137
Query: 206 HFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIM-ALICGVCLTVSMFL- 263
+F ++R +A +A+ G + F + F G+ + I+ +L+ C+ S+
Sbjct: 138 YFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRP 197
Query: 264 ----IKEDPEKRAAVEPKDASTP----FHKNLLYNIRDSFDYKSIVSDQKYLFCVLASCL 315
K + +D S+P K+ + D+ S+ + +L + + +
Sbjct: 198 LGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDF-SLFKHRGFLIYLSGNVI 256
Query: 316 AEVSTGAVLTYITSYCTTVGYSENTSFLLVTILNTLSIVGGYMFSFLADKVMGRFNVMIM 375
+ A + ++ Y G E ++ L++++ + + +A+ R +
Sbjct: 257 MFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYF 316
Query: 376 INFLLGFVPLIFWL-PFGNIGPSVMYGFSAVYGLFYGSL 413
+F + F + L P S++ ++ +GL +GS+
Sbjct: 317 FSFAIMFNGVCHLLCPLAQDYTSLVL-YAVFFGLGFGSV 354
>Hs22064599 [G] KOG2504 Monocarboxylate transporter
Length = 579
Score = 58.9 bits (141), Expect = 2e-08
Identities = 41/178 (23%), Positives = 76/178 (42%), Gaps = 8/178 (4%)
Query: 86 WLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFSG 145
W+V +F ++GL S G+ +A H D S +WI +++ + S
Sbjct: 147 WVVAAAAFAINGLSYGLLRSLGLAFPDLAEHF--DRSAQDTAWISALALAVQQAASPVGS 204
Query: 146 MYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGCICH 205
R+GAR +++G V+ G + A + + L L + G G + +P LG +
Sbjct: 205 ALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSR 264
Query: 206 HFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALI------CGVCL 257
+F +RR +A +A+ G ++ L+ G+ + ++ I CG L
Sbjct: 265 YFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALL 322
>CE03442 [G] KOG2504 Monocarboxylate transporter
Length = 417
Score = 56.2 bits (134), Expect = 1e-07
Identities = 38/167 (22%), Positives = 77/167 (45%), Gaps = 8/167 (4%)
Query: 107 GVIQTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVG 166
G ++ + + + T + ++S L+LG F +++ R GAR ++ G+ +T G
Sbjct: 6 GFVEPVIKTYNCTKDQADTAVLVVPMASSLILGP--FCSIFYQRSGARISIIAGSFLTGG 63
Query: 167 GVLAVAQCTKVWQFILALSVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGSIGG 226
+ C ++ +LA + +G G G+ + ++ C +F+K+R A G +G
Sbjct: 64 SFVVGPFCKNIYLLMLA-TFGMGIGCGLMRNSIISIQCEYFKKKRNTVMAAISIGPGLGI 122
Query: 227 VIFP---LFLEKSFKNLGFAWTMRIMALICGVCLTVSMFLIKEDPEK 270
I P F+ + + G AW ++L V + +F+ K E+
Sbjct: 123 FILPRTLKFIMVKYNSWGPAWW--FLSLFYIVSAIMGLFITKPPSEQ 167
>7303213 [G] KOG2504 Monocarboxylate transporter
Length = 678
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/176 (28%), Positives = 80/176 (44%), Gaps = 11/176 (6%)
Query: 85 AWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVSSCLLLGTSVFS 144
AW+V++ SFL G+ F +G+IQ QL E + +++ VSS LL G + +
Sbjct: 49 AWVVMVASFLCCTVIDGIVFCSGLIQ-----EQLMAEFGVSKAYVAFVSS-LLSGCYLMA 102
Query: 145 GMYF----DRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGITSSPLL 200
G + +R+G R + G + T V L V G G + P +
Sbjct: 103 GPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAV 162
Query: 201 GCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALICGVC 256
I +F+K RA+AT VA+ G +G +F L K G+ +T+ I +I C
Sbjct: 163 VIIGFYFEKWRALATGVAMCGSGVGTFVFAP-LTKILLKSGWRYTLAIQGIIVLSC 217
>7295764 [G] KOG2504 Monocarboxylate transporter
Length = 1131
Score = 56.2 bits (134), Expect = 1e-07
Identities = 87/426 (20%), Positives = 172/426 (39%), Gaps = 32/426 (7%)
Query: 76 FTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVSSC 135
+ Y +GG W++ SFL + T GL S G++ Y ++ +TS + + ++S
Sbjct: 408 YFYPDGGWG-WIICGVSFLVHILTTGLQLSYGLLWFYAVQYL---HNTSGIELLGALSWS 463
Query: 136 LLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSGIT 195
+ + + F + R ++G ++ G+L + T+ Q + + + G G +
Sbjct: 464 VSMVATSFVVSLCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMV 523
Query: 196 SSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALICGV 255
+ ++F++RR VA++G +G +F + L++ G+ ++I+A
Sbjct: 524 REASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQIVA----- 578
Query: 256 CLTVSMFLIKEDPEKRAAVEPKDASTPFHKNLLYNIRDSFDYKS--IVSDQKYLFCVLAS 313
LT F + + P+ + KN +R+ S + S KY F ++S
Sbjct: 579 ALTALSFFMGLMYRPASLYHPQRRAIQHLKNQRKKMREKKPILSQDVESTPKYFFLDISS 638
Query: 314 --------CLAEVSTGAVLTYITSYCTTVGYSENTS-----FLLVTILNTLSIVGGYMFS 360
L S + Y + + +E S LL T L +G +
Sbjct: 639 LKSVTVKILLMTSSVASFGIYTPMFLMALNAAEQGSDVQELVLLQTFLGISMALGVVIAG 698
Query: 361 FLADK--VMGRF--NVMIMINFLLGFVPL-IFWLPFGNIGPSVMYGFSAVYGLFYGSLIN 415
L + V+ F N I+ L V L I +L F +G + + S +YG+ G
Sbjct: 699 ALLRRCFVIRHFVINTKIVTQLFLSIVALAILFLSF-VMGYTGLCILSWLYGIGLGGFQY 757
Query: 416 LAPVCCGQISRTNEFGRRYATMYCFVGLSFLVAIPVSGVIIGDGSLKNYNNFIIYVSVLS 475
+ + + F + + + + L+++P++ + D SLK Y Y+ +
Sbjct: 758 SLKILALERIKLKHFSKAWGFIRGVESVPVLISVPLTS-FLNDYSLK-YGRAGYYICSAA 815
Query: 476 MISSGL 481
SG+
Sbjct: 816 AAISGI 821
>7293575 [G] KOG2504 Monocarboxylate transporter
Length = 645
Score = 55.8 bits (133), Expect = 1e-07
Identities = 51/207 (24%), Positives = 90/207 (42%), Gaps = 7/207 (3%)
Query: 74 DGFTYAEGGIAAWLVVLGSFLGILPTWGLYFSAGVIQTYVARHQLKDESTSTVSWIFSVS 133
+ F +GG WLV + S + IL T+ L G++ + R S+S ++ I +
Sbjct: 75 EDFVAPDGGWG-WLVSVASGVNILVTFALAQQFGIL--FRDRMAGLGISSSELTTIINTQ 131
Query: 134 SCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQFILALSVCVGTGSG 193
+ T + +G F RY R ++G+V+T G+ + +I++ S+ G G G
Sbjct: 132 IAVSAFTGLLNGPLFRRYTYRVVALVGSVLTFLGLFWMVFADTFAVYIMSFSILYGFGRG 191
Query: 194 ITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNLGFAWTMRIMALIC 253
+T S + +F+ +R ATA +G ++ P F G T + A
Sbjct: 192 LTVSASSLAVNTYFKVKRRTATAFQFGVAGLGPIVCPYFATYMLYEFGVQGTTLLFA--- 248
Query: 254 GVCL-TVSMFLIKEDPEKRAAVEPKDA 279
G L T++ LI + + +DA
Sbjct: 249 GASLHTIACSLIYQPVKWHVVKRDRDA 275
>7293576 [G] KOG2504 Monocarboxylate transporter
Length = 655
Score = 54.7 bits (130), Expect = 3e-07
Identities = 40/156 (25%), Positives = 73/156 (46%), Gaps = 11/156 (7%)
Query: 121 ESTSTVSWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQF 180
++T+ V+ + ++SS + + +G F R+ R+ + GT + GV A CT WQ+
Sbjct: 82 QTTTIVNVVMAISSLV----GIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQY 137
Query: 181 ILALSVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGSIGGVIFPLFLEKSFKNL 240
I+ LS G G G+ + + +F+ +R AT + +G + FP
Sbjct: 138 IICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYY 197
Query: 241 GFAWTMRIM------ALICGVCLTVSMFLIKEDPEK 270
G T+ I A++C + L ++ +K+ PEK
Sbjct: 198 GAQGTILIYAGIAMNAILCALTLQPVLWHVKK-PEK 232
>Hs7019529 [G] KOG2504 Monocarboxylate transporter
Length = 504
Score = 53.1 bits (126), Expect = 1e-06
Identities = 26/105 (24%), Positives = 50/105 (46%)
Query: 120 DESTSTVSWIFSVSSCLLLGTSVFSGMYFDRYGARKPLVIGTVMTVGGVLAVAQCTKVWQ 179
D S +W+ S+ +L GT S + R+G R ++ G ++ G++ + T++ +
Sbjct: 51 DAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLE 110
Query: 180 FILALSVCVGTGSGITSSPLLGCICHHFQKRRAIATAVAINGGSI 224
L V G G + P L + +F++RR +A +A G +
Sbjct: 111 LYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPV 155
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.325 0.140 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,640,034
Number of Sequences: 60738
Number of extensions: 1274274
Number of successful extensions: 4189
Number of sequences better than 1.0e-05: 32
Number of HSP's better than 0.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 4126
Number of HSP's gapped (non-prelim): 46
length of query: 518
length of database: 30,389,216
effective HSP length: 111
effective length of query: 407
effective length of database: 23,647,298
effective search space: 9624450286
effective search space used: 9624450286
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)