ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0903 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0903 309127 310281 385
(385 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIL120w [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 320 3e-87
YIL121w [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 300 2e-81
YNL065w [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 232 6e-61
YBR180w [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 98 2e-20
YBR043c [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 78 3e-14
YBR008c [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 59 1e-08
SPBC16A3.17c [R] KOG0254 Predicted transporter (major facilitato... 57 5e-08
SPBC12C2.13c [R] KOG0254 Predicted transporter (major facilitato... 54 4e-07
>YIL120w [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 563
Score = 320 bits (819), Expect = 3e-87
Identities = 155/340 (45%), Positives = 221/340 (64%), Gaps = 8/340 (2%)
Query: 39 EEHATEPQNLYMEHAEKIQKTDNRLDVTDSNRQLSLLNSTKSETNFDGIPYTRFSKHDKL 98
E ++ N+ ++ I +DN + ++S+ ++ +E+NFD +PY+RFS K+
Sbjct: 18 EREGSDNNNVDRSSSDAI--SDNDAERSNSHSEID------NESNFDMVPYSRFSHKQKM 69
Query: 99 FLVVICALSGFYSTIAQTIYFPALSIIEKEFXXXXXXXXXXXXXYSLCQGIFPVIMGGLA 158
LVV CA +GF+ST+A +IY+P L+IIE++F Y + QG+ P IMGGLA
Sbjct: 70 LLVVQCAFTGFFSTVAGSIYYPVLTIIERKFNITEELANVTIVVYFIFQGVAPSIMGGLA 129
Query: 159 DRLGRRPVAMFCIMVYFCACIGIACCRTFGEMIFLRCLQGGGISPIIAINNGLMGDITVK 218
D GRRP+ ++ I+ YFCACIG+AC + +++ LRCLQ GISP+IAIN+G+MGD+T K
Sbjct: 130 DTFGRRPIVLWAILAYFCACIGLACAHNYAQILALRCLQAAGISPVIAINSGIMGDVTTK 189
Query: 219 SERGGYVGLTSGFQVXXXXXXXXXXXXFTARWGWRSIFWFLSAGSGVTLLFVVTALPETK 278
ERGGYVGL +GFQV +++WGWR+IFWFL+ GSG+ L+F +PETK
Sbjct: 190 VERGGYVGLVAGFQVVGTAFGALIGAGLSSKWGWRAIFWFLAIGSGICLVFSTLLMPETK 249
Query: 279 RSIVGNGSIKPPHLISRSVLLGAPYYKKKLHLDNPDYETKTENASYDPLAPFKIMVRPEL 338
R++VGNGS+ P ++RS++L KK LHLD+PD ET S D LAP KI+ E+
Sbjct: 250 RTLVGNGSVTPRSFLNRSLILHVGSVKKTLHLDDPDPETLEPRTSVDFLAPLKILHIREI 309
Query: 339 ISLLAVQGLQFTTWICHMTTLSEHLNKDYGLPMVIIGVCF 378
LL++ GLQF+TW H T L+ L+K Y L + IG+CF
Sbjct: 310 DILLSIAGLQFSTWTTHQTALTIVLSKKYNLSVAKIGLCF 349
>YIL121w [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 542
Score = 300 bits (768), Expect = 2e-81
Identities = 152/331 (45%), Positives = 204/331 (60%), Gaps = 4/331 (1%)
Query: 51 EHAEKIQKTDNRLDVTDSNRQLSLLNSTKSETNFDGIPYTRFSKHDKLFLVVICALSGFY 110
E AE +Q + T L+ S K E P++RFS+ K L+ CA +GF+
Sbjct: 17 ELAESMQSYNRE---TADKLALTRTESVKPEPEITAPPHSRFSRSFKTVLIAQCAFTGFF 73
Query: 111 STIAQTIYFPALSIIEKEFXXXXXXXXXXXXXYSLCQGIFPVIMGGLADRLGRRPVAMFC 170
STIA IY+P LS+IE++F Y + QG+ P MGG AD LGRRPV +
Sbjct: 74 STIAGAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVA 133
Query: 171 IMVYFCACIGIACCRTFGEMIFLRCLQGGGISPIIAINNGLMGDITVKSERGGYVGLTSG 230
I++YF ACIG+AC +T+ ++I LRCLQ GISP+IAIN+G+MGD+T ++ERGGYVG +G
Sbjct: 134 IVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGDVTTRAERGGYVGYVAG 193
Query: 231 FQVXXXXXXXXXXXXFTARWGWRSIFWFLSAGSGVTLLFVVTALPETKRSIVGNGSIKPP 290
FQV ++RWGWR+IFWFL+ GSG+ L LPETKR+I GNGS+ P
Sbjct: 194 FQVLGSAFGALIGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPK 253
Query: 291 HLISRSVLLGAPYYKKKLHLDNPDYETKTENASYDPLAPFKIMVRPELISLLAVQGLQFT 350
++R+ +L P +K LHLDNPDYET + LAPFKI+ E+ L+ V GLQF
Sbjct: 254 SYLNRAPILVLPTVRKSLHLDNPDYETLELPTQLNLLAPFKILKAYEICILMLVAGLQFA 313
Query: 351 TWICHMTTLSEHLNKDYGLPMVIIGVCFYLP 381
+ H+T LS L+K Y L + +G+C YLP
Sbjct: 314 MYTTHLTALSTALSKQYHLTVAKVGLC-YLP 343
>YNL065w [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 586
Score = 232 bits (592), Expect = 6e-61
Identities = 131/318 (41%), Positives = 179/318 (56%), Gaps = 3/318 (0%)
Query: 66 TDSNRQLSLLNSTKSETNFDGIPYTRFSKHDKLFLVVICALSGFYSTIAQTIYFPALSII 125
T S+ ++ T+ T PYT S K +V I + GF+S++ IY+PAL +
Sbjct: 68 TSSHSSDDKVDPTQQITAETKAPYTLLSYGQKWGMVAILTMCGFWSSLGSPIYYPALRQL 127
Query: 126 EKEFXXXXXXXXXXXXXYSLCQGIFPVIMGGLADRLGRRPVAMFCIMVYFCACIGIACCR 185
EK+F Y L QGI P + GGLAD GRRP+ + +++Y A IG+AC
Sbjct: 128 EKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAP 187
Query: 186 TFGEMIFLRCLQGGGISPIIAINNGLMGDITVKSERGGYVGLTSGFQVXXXXXXXXXXXX 245
++G +IFLRC+Q GISP IAI++G++GD T+K ERG +VG TSGF +
Sbjct: 188 SYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAV 247
Query: 246 FTARWGWRSIFWFLSAGSGVTLLFVVTALPETKRSIVGNGSIKPPHLISRSVLLGAPYYK 305
TARW WR+IFWFL+ G G L LPETKR+I GN SIKP I+R+ + +
Sbjct: 248 LTARWDWRAIFWFLTIGCGSCFLIAFLILPETKRTIAGNLSIKPKRFINRAPIFLLGPVR 307
Query: 306 KKLHLDNPDYETKTEN-ASYDPLAPFKIMVRPELISLLAVQGLQFTTWICHMTTLSEHLN 364
++ DNPDYET D + KI+V PE+I L GL F W ++++S L+
Sbjct: 308 RRFKYDNPDYETLDPTIPKLDLSSAGKILVLPEIILSLFPSGLLFAMWTLMLSSISSGLS 367
Query: 365 -KDYGLPMVIIGVCFYLP 381
Y +VIIGVC YLP
Sbjct: 368 VAPYNYHLVIIGVC-YLP 384
>YBR180w [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 572
Score = 98.2 bits (243), Expect = 2e-20
Identities = 92/401 (22%), Positives = 160/401 (38%), Gaps = 38/401 (9%)
Query: 15 MDDEESHVSVSSYNNMDDDDDEVLEE--------HATEPQNLYMEH--------AEKIQK 58
++ +ES + S++++++D D+V+ E A +++ EH A+K +
Sbjct: 15 INSQESGTTRSTFHSLEDLGDDVINESWDQVNQKRANIDHDVFHEHPDSSPSLSAQKAKT 74
Query: 59 TDNRLDVTDSNRQLSLLNSTKSETNFDGIPYTRFSKHDKLFLVVICALSGFYSTIAQTIY 118
+ + V SN Q + S IPYT FSK +L + I GF ++ IY
Sbjct: 75 KEEEVAVKSSNSQ----SRDPSPDTQAHIPYTYFSKDQRLIIFGIIIFIGFLGPMSGNIY 130
Query: 119 FPALSIIEKEFXXXXXXXXXXXXXYSLCQGIFPVIMGGLADRLGRRPVAMFCIMVYFCAC 178
PAL ++++E+ + + P+ G LAD GR+ + M + +
Sbjct: 131 IPALPLLQREYDVSATTINATVSVFMAVFSVGPLFWGALADFGGRKFLYMVSLSLMLIVN 190
Query: 179 IGIACCR-TFGEMIFLRCLQGGGISPIIAINNGLMGDITVKSERGGYVG-LTSGFQVXXX 236
I +A + LR Q S +I++ G + D+ RG + G +
Sbjct: 191 ILLAAVPVNIAALFVLRIFQAFASSSVISLGAGTVTDVVPPKHRGKAIAYFMMGPNMGPI 250
Query: 237 XXXXXXXXXFTARWGWRSIFWFLSAGSGVTLLFVVTALPETKRSIVGNGSIKPPHLISRS 296
WR +F F S +G+ L+ V LPET R IVGNG K
Sbjct: 251 IAPIVAGLILMKGNYWRWLFGFTSIMTGIALILVTALLPETLRCIVGNGDPKWGDKKDER 310
Query: 297 VLLGAPYYK------KKLHLDNPDYETKTENASYDPLAP----------FKIMVRPELIS 340
+P+++ ++L D + +A + P +K++ P +I
Sbjct: 311 ENNESPFFEGNKISHRRLFPDIGIRKPVNNDAFFQENFPKPPKAGLTLYWKMIKCPPIII 370
Query: 341 LLAVQGLQFTTWICHMTTLSEHLNKDYGLPMVIIGVCFYLP 381
L F+++ T S +L DY M+ IG + P
Sbjct: 371 TSVSTALLFSSYYAFSVTFSYYLEHDYRFTMLEIGAAYVCP 411
>YBR043c [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 689
Score = 77.8 bits (190), Expect = 3e-14
Identities = 70/296 (23%), Positives = 112/296 (37%), Gaps = 14/296 (4%)
Query: 3 EGEYSDESKLKTMDDEESHVSVSSYNNMDDDDDEVLEEH---ATEPQNLYMEHAEKIQKT 59
+G S+ L++ + S + + D+ EH + E NL + +
Sbjct: 4 QGSQSNVGSLRSNCSDNSLPNNHVMMHCDESSGTPHSEHNDYSYEKTNLESTASNSREHR 63
Query: 60 DNRLD-------VTDSNRQLSLLNSTKSETNF-DGIPYTRFSKHDKLFLVVICALSGFYS 111
DN+L V N++ LL F D Y K +FL+ ++ G
Sbjct: 64 DNQLSRLKSEEYVVPKNQRRGLLPQLAIIPEFKDARDYPPMMKKMIVFLIAFSSMMGPMG 123
Query: 112 TIAQTIYFPALSIIEKEFXXXXXXXXXXXXXYSLCQGIFPVIMGGLADRLGRRPVAMFCI 171
T +I FPA++ I EF Y L G+FP+ L++ GRR +
Sbjct: 124 T---SIIFPAINSITTEFKTSVIMVNVSIGVYLLSLGVFPLWWSSLSELEGRRTTYITSF 180
Query: 172 MVYFCACIGIACCRTFGEMIFLRCLQGGGISPIIAINNGLMGDITVKSERGGYVGLTSGF 231
+ F IG A I LR L G + + ++ G + D+ + +RG +
Sbjct: 181 ALLFAFNIGSALAPDINSFIALRMLCGAASASVQSVGAGTVADLYISEDRGKNLSYYYLG 240
Query: 232 QVXXXXXXXXXXXXFTARWGWRSIFWFLSAGSGVTLLFVVTALPETKRSIVGNGSI 287
+ RW WRS WF+ SG ++ + LPET R G+I
Sbjct: 241 PLLAPLLSPIFGSLLVNRWPWRSTQWFMVILSGCNVILLTVLLPETLRKQDSKGAI 296
>YBR008c [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 548
Score = 58.9 bits (141), Expect = 1e-08
Identities = 55/219 (25%), Positives = 83/219 (37%), Gaps = 9/219 (4%)
Query: 113 IAQTIYFPALSIIEKEFXXXXXXXXXXXXXYSLCQGIFPVIMGGLAD--RLGRRPVAMFC 170
+ +IY P I++EF Y L G+ P+I L++ R GR + M
Sbjct: 118 MGSSIYTPGQEYIQEEFHVGHVVATLNLSLYVLGYGLGPIIFSPLSETARYGRLNLYMVT 177
Query: 171 IMVYFCACIGIACCRTFGEMIFLRCLQGGGISPIIAINNGLMGDITVKSERGGYVGLTSG 230
+ + +G A G +I +R + G SP +A G + DI +G+ S
Sbjct: 178 LFFFMIFQVGCATVHNIGGLIVMRFISGILCSPSLATGGGTVADIISPEMVPLVLGMWSA 237
Query: 231 FQVXXXXXXXXXXXXFTARWGWRSIFWFLSAGSGVTLLFVVTALPETK-RSIVGNGSIKP 289
V WR IFW L S T + + PET+ +I+ ++K
Sbjct: 238 GAVAAPVLAPLLGAAMVDAKNWRFIFWLLMWLSAATFILLAFFFPETQHHNILYRRALK- 296
Query: 290 PHLISRSVLLGAPYYKKKLHLDNP-DYETKTENASYDPL 327
R YY ++ LD D T N Y PL
Sbjct: 297 ----LRKETGDDRYYTEQDKLDREVDARTFLINTLYRPL 331
>SPBC16A3.17c [R] KOG0254 Predicted transporter (major facilitator superfamily)
Length = 599
Score = 57.0 bits (136), Expect = 5e-08
Identities = 58/233 (24%), Positives = 96/233 (40%), Gaps = 14/233 (6%)
Query: 49 YMEHAEK-IQKTD-----NRLDVTDSNRQLSLLNSTKSETNFDGIPYTRFSKHDKLFLVV 102
Y + EK +++TD N+++ D ++Q + + +S +N D +++ +V
Sbjct: 41 YPSNEEKEVKETDIVPDENKVNELDVHKQSTEFSKQESASNDDDTNIQLIPENNMKIVVP 100
Query: 103 ICALSGFYSTIAQTIYFPALSIIEKEFXXXXXXXXXXXXXYSLCQGIFPVIMGGLADRLG 162
L+ F + + TI AL I ++F + P + G + LG
Sbjct: 101 ALILTLFLAALDNTIVTTALPTIAEDFNDTSSSSWIGSAYVLASNAVLPAV-GVFCNILG 159
Query: 163 RRPVAMFCIMVYFCACIGIACCRTFGEMIFL---RCLQGGGISPIIAINNGLMGDITVKS 219
R+ V CI + +G A C MI+L R +QG G II++ N ++ DIT
Sbjct: 160 RKIVLYICIFFFM---LGSALCGASQNMIWLIVCRAIQGLGGGGIISLVNIIISDITPLR 216
Query: 220 ERGGYVGLTSGFQVXXXXXXXXXXXXFTARWGWRSIFWF-LSAGSGVTLLFVV 271
R Y G+ + R WR IF+ L +G T L VV
Sbjct: 217 TRPMYSGILATAWGAALVAGPIIGGAICQRTTWRWIFFINLPSGGIATALIVV 269
>SPBC12C2.13c [R] KOG0254 Predicted transporter (major facilitator superfamily)
Length = 531
Score = 53.9 bits (128), Expect = 4e-07
Identities = 38/153 (24%), Positives = 57/153 (36%), Gaps = 1/153 (0%)
Query: 106 LSGFYSTIAQTIYFPALSIIEKEFXXXXXXXXXXXXXYSLCQGIFPVIMGGLADRLGRRP 165
+ GF S + TI +I EF Y + F + G L+D GRRP
Sbjct: 39 VGGFLSALDMTIVASLYPVIGSEFKLMNNASYIVTA-YLITNTAFQPLYGRLSDIFGRRP 97
Query: 166 VAMFCIMVYFCACIGIACCRTFGEMIFLRCLQGGGISPIIAINNGLMGDITVKSERGGYV 225
+F + R+ E+ R L G G + +++ + DI ERG +
Sbjct: 98 TVVFANAAFTLGTFWCGISRSLPELCMARALAGIGGGGLGTMSSIISSDIVSLRERGTWQ 157
Query: 226 GLTSGFQVXXXXXXXXXXXXFTARWGWRSIFWF 258
G+T+ RWGWR+ F F
Sbjct: 158 GITNIVWGIGGSLGGPLGGLIAQRWGWRTAFHF 190
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.323 0.140 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,413,683
Number of Sequences: 60738
Number of extensions: 928854
Number of successful extensions: 3893
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 3881
Number of HSP's gapped (non-prelim): 9
length of query: 385
length of database: 30,389,216
effective HSP length: 108
effective length of query: 277
effective length of database: 23,829,512
effective search space: 6600774824
effective search space used: 6600774824
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)