ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0904 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0904 Some similarity with YIL121w SP|P40474
{P12.2.f3.1}
(241 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIL121w [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 199 4e-51
YIL120w [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 179 3e-45
YNL065w [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 115 4e-26
YBR180w [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 54 3e-07
YBR043c [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 54 3e-07
YNR055c [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 35 0.12
YHR048w [R] KOG0255 Synaptic vesicle transporter SVOP and relate... 33 0.47
Hs7706029 [S] KOG4837 Uncharacterized conserved protein 30 2.3
SPBC1271.10c [R] KOG0255 Synaptic vesicle transporter SVOP and r... 30 4.0
Hs19923753 [G] KOG2504 Monocarboxylate transporter 30 4.0
Hs16554453 [O] KOG0978 E3 ubiquitin ligase involved in syntaxin ... 30 4.0
CE20770 [T] KOG2322 N-methyl-D-aspartate receptor glutamate-bind... 30 4.0
7302074 [R] KOG4334 Uncharacterized conserved protein contains d... 30 4.0
CE03303 [R] KOG3656 FOG: 7 transmembrane receptor 29 6.8
At1g61190 [T] KOG4658 Apoptotic ATPase 29 6.8
YOR115c [U] KOG3316 Transport protein particle (TRAPP) complex s... 28 8.8
YDL006w [T] KOG0698 Serine/threonine protein phosphatase 28 8.8
>YIL121w [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 542
Score = 199 bits (505), Expect = 4e-51
Identities = 91/198 (45%), Positives = 138/198 (68%)
Query: 2 FLPAGLCTLTSVVLAGKFLNWNYRRRFAKHKKFIQNEKKILLEENDYDSQLVRDIIDQDI 61
+LP+G+CTL S+V+AG++LNWNYRRR ++ ++ ++ LLEE+D D LV+ II+ D
Sbjct: 341 YLPSGICTLCSIVIAGRYLNWNYRRRLKYYQNWLGKKRSKLLEEHDNDLNLVQRIIENDP 400
Query: 62 QHKFDLYKTRLDYAYVPIIISNAGFIIFGWCIGTKQHLAVILVMSGLASLMCNCMISISN 121
++ F+++K RL A+V +++S++GF +GWCI K LA +L MSG ASL NC+++ S
Sbjct: 401 KYTFNIFKARLQPAFVTLLLSSSGFCAYGWCITVKAPLAAVLCMSGFASLFSNCILTFST 460
Query: 122 TLVVDLYPERASTAAGCVNFVRCIFTAIMVAALAKMNSSMTVGGTFTFLTCLAWVCSMLL 181
TL+VDL+P + STA GC+N RCI +A+ +AAL+KM M GG FTFL L S+LL
Sbjct: 461 TLIVDLFPTKTSTATGCLNLFRCILSAVFIAALSKMVEKMKFGGVFTFLGALTSSSSILL 520
Query: 182 IVPMKYGLRLQLAREKKQ 199
+ ++ G L R+K++
Sbjct: 521 FILLRKGKELAFKRKKQE 538
>YIL120w [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 563
Score = 179 bits (454), Expect = 3e-45
Identities = 88/205 (42%), Positives = 132/205 (63%), Gaps = 1/205 (0%)
Query: 2 FLPAGLCTLTSVVLAGKFLNWNYRRRFAKHKKFIQNEKKILLEENDYDSQLVRDIIDQDI 61
FLPAG+ TLTS++ AG++LNW+YR R K+ ++I+ ++ L+E+ D V ++I +
Sbjct: 349 FLPAGISTLTSIISAGRYLNWSYRTRKVKYNRWIKEQELQLMEKYKGDKNKVAELIHSNS 408
Query: 62 QHKFDLYKTRLDYAYVPIIISNAGFIIFGWCIGTKQHLAVILVMSGLASLMCNCMISISN 121
+ F+L + RL A+V +++S+ GF FGWCI K LA +L S ASL NC+++ S
Sbjct: 409 HYAFNLVEARLHPAFVTLLLSSIGFTAFGWCISVKTPLAAVLCTSAFASLFSNCILTFST 468
Query: 122 TLVVDLYPERASTAAGCVNFVRCIFTAIMVAALAKMNSSMTVGGTFTFLTCLAWVCSMLL 181
TL+VDL+P +ASTA GC+N RC+ +AI +AAL KM M GG FTFL+ + S+LL
Sbjct: 469 TLIVDLFPSKASTATGCLNLFRCLLSAIFIAALTKMVEKMRYGGVFTFLSAITSSSSLLL 528
Query: 182 IVPMKYGLRLQLAREKKQSQKTLGR 206
+K G +L R + + K+ GR
Sbjct: 529 FYLLKNGKQLSFDR-IRANDKSAGR 552
>YNL065w [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 586
Score = 115 bits (289), Expect = 4e-26
Identities = 66/202 (32%), Positives = 108/202 (52%), Gaps = 19/202 (9%)
Query: 2 FLPAGLCTLTSVVLAGKFLNWNYRRRFAKHKKFIQNEKKILLEENDYDSQLVRDIIDQDI 61
+LP G+ L G+ ++ ++R+ KKF Q++ +I QD
Sbjct: 382 YLPGGIGGLMGSFFTGRIIDMYFKRKI---KKFEQDK--------------ANGLIPQDA 424
Query: 62 QHKFDLYKTRLDYAYVPIIISNAGFIIFGWCIGTKQHLAVILVMSGLASLMCNCMISISN 121
+ +++K RL ++ +++FGW I + IL+ S + S +S S
Sbjct: 425 E--INMFKVRLVCLLPQNFLAVVAYLLFGWSIDKGWRIESILITSFVCSYCAMSTLSTST 482
Query: 122 TLVVDLYPERASTAAGCVNFVRCIFTAIMVAALAKMNSSMTVGGTFTFLTCLAWVCSMLL 181
TL+VDLYP ++STA+ C NFVRC + I + AKM ++MTVGGTFTFL L + + L+
Sbjct: 483 TLLVDLYPTKSSTASSCFNFVRCSLSTIFMGCFAKMKAAMTVGGTFTFLCALVFFFNFLM 542
Query: 182 IVPMKYGLRLQLAREKKQSQKT 203
+PMKYG++ + R KQ +++
Sbjct: 543 FIPMKYGMKWREDRLLKQQRQS 564
>YBR180w [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 572
Score = 53.5 bits (127), Expect = 3e-07
Identities = 35/122 (28%), Positives = 61/122 (49%), Gaps = 4/122 (3%)
Query: 71 RLDYAYVPIIISNAGFIIFGWCIGTKQHLAVILVMSGLASLMCNCMISISNTLVVDLYPE 130
RL + I+++ G I +GW I H V+LV S L + + S T + +L+P+
Sbjct: 447 RLLLNLIGILLTICGTIGYGWAIFFHYHFVVLLVFSALTAFGMTWCSNTSMTYLTELFPK 506
Query: 131 RASTAAGCVNFVRCIFTAIMVAALAKMNSSMTVGGTFTFLTCLAWVCSMLLIVPMKYGLR 190
RA+ +F R + AI A + ++ ++M +G FT L +CS + ++ + Y L
Sbjct: 507 RAAGTVAVSSFFRNVGAAISSAIILQLCNAMGIGWCFTGL----GLCSSISLIGILYLLI 562
Query: 191 LQ 192
Q
Sbjct: 563 FQ 564
>YBR043c [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 689
Score = 53.5 bits (127), Expect = 3e-07
Identities = 34/121 (28%), Positives = 53/121 (43%), Gaps = 1/121 (0%)
Query: 69 KTRLDYAYVPIIIS-NAGFIIFGWCIGTKQHLAVILVMSGLASLMCNCMISISNTLVVDL 127
+ R+ + V +IS +IFGWC+ K H L+ + L I + + +VD
Sbjct: 552 EARISWNVVTSVISFPIALLIFGWCLDKKCHWVTPLIGTALFGYAAMMTIGATLSYLVDS 611
Query: 128 YPERASTAAGCVNFVRCIFTAIMVAALAKMNSSMTVGGTFTFLTCLAWVCSMLLIVPMKY 187
P + +T N +R I A V M + M G FT L + S +LI+ K+
Sbjct: 612 LPGKGATGVALNNLIRQILAATAVFVTTPMLNGMGTGWAFTMLAFIVLGASSVLIILKKH 671
Query: 188 G 188
G
Sbjct: 672 G 672
>YNR055c [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 586
Score = 34.7 bits (78), Expect = 0.12
Identities = 32/143 (22%), Positives = 54/143 (37%), Gaps = 8/143 (5%)
Query: 71 RLDYAYVPIIISNAGFIIFGWCIGTKQHLAVILVMSGLASLMCNCMISISNTLVVDLYPE 130
RL ++ II AG ++FG + I V G C I+ ++D YP+
Sbjct: 448 RLYFSIATAIIGPAGLLMFGIGTARQWPWQAIYVGLGFVGFAWGCSGDIAMAYLMDCYPD 507
Query: 131 RASTAAGCV----NFVRCIFTAIMVAALAKMNSSMTVGGTFTFLTCLAWVCSMLLIVPMK 186
C N + CIFT LA + T+ L + + + +
Sbjct: 508 MVLEGMVCTAIINNTISCIFTFTCSDWLAASGTE----NTYIALAVINFGITAFALPMYY 563
Query: 187 YGLRLQLAREKKQSQKTLGRENI 209
YG R++L ++ Q R+ +
Sbjct: 564 YGKRIRLWTKRWYLQSVNLRDGV 586
>YHR048w [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 514
Score = 32.7 bits (73), Expect = 0.47
Identities = 32/125 (25%), Positives = 49/125 (38%), Gaps = 6/125 (4%)
Query: 71 RLDYAYVPIIISNAGFIIFGWCIGTKQHLAVILVMSGLASLMCNCMISISNTLVVDLYPE 130
R + + ++ G IF + H ++ S + + + VD Y
Sbjct: 384 RFEPLFYGAFLTPVGLFIFAFTCYKHVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAYRR 443
Query: 131 RASTAAGCVNFVRCIFTAIMVAALAKMNSSMTVGGTFTFLTCLAWVCSMLLIVPM---KY 187
A++ C FVRCI + +M SM V FL LA V ++ VP KY
Sbjct: 444 YAASGMACNTFVRCIMAGVFPLFGLQMYKSMGVNWA-GFL--LAMVTVAMIPVPFLFTKY 500
Query: 188 GLRLQ 192
G RL+
Sbjct: 501 GARLR 505
>Hs7706029 [S] KOG4837 Uncharacterized conserved protein
Length = 240
Score = 30.4 bits (67), Expect = 2.3
Identities = 14/37 (37%), Positives = 23/37 (61%)
Query: 191 LQLAREKKQSQKTLGRENIDENNIHPEMSEEERELCD 227
++ + K+S + + E+ DE + H EMSE+E EL D
Sbjct: 88 IRSTKSTKKSLQKVDEEDSDEESHHDEMSEQEEELED 124
>SPBC1271.10c [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 581
Score = 29.6 bits (65), Expect = 4.0
Identities = 31/143 (21%), Positives = 50/143 (34%)
Query: 69 KTRLDYAYVPIIISNAGFIIFGWCIGTKQHLAVILVMSGLASLMCNCMISISNTLVVDLY 128
++RL +P II+ G +FG H V G C IS ++D Y
Sbjct: 423 ESRLWLMILPCIINPIGLFMFGIGTARHWHWGPTYVGLGFIGFGWGCAGDISMAYLMDAY 482
Query: 129 PERASTAAGCVNFVRCIFTAIMVAALAKMNSSMTVGGTFTFLTCLAWVCSMLLIVPMKYG 188
P A V+ + F + A S+ T+ + L ++ + G
Sbjct: 483 PGMVLEAMVGVSVINNTFGYVFTFACQSWIDSLGTERTYISIGVLCFIFIATSFPMILCG 542
Query: 189 LRLQLAREKKQSQKTLGRENIDE 211
RL+ K+ R +DE
Sbjct: 543 KRLRKWTAKQYYTFLNVRNRLDE 565
>Hs19923753 [G] KOG2504 Monocarboxylate transporter
Length = 500
Score = 29.6 bits (65), Expect = 4.0
Identities = 26/107 (24%), Positives = 44/107 (40%), Gaps = 4/107 (3%)
Query: 104 VMSGLASLMCNCMISISNTLVVDLY-PERASTAAGCVNFVRCIFTAIMVAALAKMNSSMT 162
V +G + S+ ++DL P+R S+A G V V C + L ++N M
Sbjct: 358 VYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLN-DMY 416
Query: 163 VGGTFTFLTC--LAWVCSMLLIVPMKYGLRLQLAREKKQSQKTLGRE 207
+T+ C + + + L + M RL +K QK +E
Sbjct: 417 GDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKE 463
>Hs16554453 [O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation
Length = 975
Score = 29.6 bits (65), Expect = 4.0
Identities = 15/37 (40%), Positives = 19/37 (50%)
Query: 191 LQLAREKKQSQKTLGRENIDENNIHPEMSEEERELCD 227
+Q REK + L E I N IH + EE+ EL D
Sbjct: 750 MQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELAD 786
>CE20770 [T] KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit
Length = 295
Score = 29.6 bits (65), Expect = 4.0
Identities = 20/94 (21%), Positives = 41/94 (43%), Gaps = 11/94 (11%)
Query: 92 CIGTKQHLAVILVMSGLASLMCNCMISISNTLVVDLYPERASTAAGCVNFVRCIFTAIMV 151
C G ++ V L+++G+ +L + M T+V+ + + + C F+ ++V
Sbjct: 139 CEGVRRKFPVNLIVTGIFTLATSVM-----TMVISAHHDANVVLLALAICIGCTFSIVIV 193
Query: 152 AALAK------MNSSMTVGGTFTFLTCLAWVCSM 179
A+ K M + + F F + +CSM
Sbjct: 194 ASQTKFDLTAHMGYILIISMCFMFFGLVVVICSM 227
>7302074 [R] KOG4334 Uncharacterized conserved protein contains
double-stranded RNA-binding motif and WW domain
Length = 642
Score = 29.6 bits (65), Expect = 4.0
Identities = 12/33 (36%), Positives = 22/33 (66%)
Query: 13 VVLAGKFLNWNYRRRFAKHKKFIQNEKKILLEE 45
V+ +F +WN RR+F K++K I+N ++ L +
Sbjct: 303 VIRVLRFRSWNARRKFTKNRKHIKNIQRPTLPD 335
>CE03303 [R] KOG3656 FOG: 7 transmembrane receptor
Length = 412
Score = 28.9 bits (63), Expect = 6.8
Identities = 12/40 (30%), Positives = 22/40 (55%), Gaps = 1/40 (2%)
Query: 157 MNSSMTVGGTFTFLTCLAWVCSMLLIVPMKYGLRLQLARE 196
+N M++ +F+ L W+CS+LL+ P ++L E
Sbjct: 154 INDRMSMRSCLSFIV-LIWLCSLLLVTPYAINMKLNYIHE 192
>At1g61190 [T] KOG4658 Apoptotic ATPase
Length = 967
Score = 28.9 bits (63), Expect = 6.8
Identities = 19/51 (37%), Positives = 25/51 (48%), Gaps = 2/51 (3%)
Query: 172 CLAWVCSMLLIVPMKYGLRLQLAREKKQSQKTLGRENIDENNIHPEMSEEE 222
CL +CS + KYG R+ L E+ K+ G N DE + P SE E
Sbjct: 99 CLCGLCSKYVCSSYKYGKRVFLLLEEVTKLKSEG--NFDEVSQPPPRSEVE 147
>YOR115c [U] KOG3316 Transport protein particle (TRAPP) complex subunit
Length = 268
Score = 28.5 bits (62), Expect = 8.8
Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 176 VCSMLL--IVPMKYGLRLQLAREKKQSQKTLGRENIDENNIHPEMSEEERELCDLRRSAT 233
V MLL +VP+ G+ Q++ + S + EN + NN+ + EE D+ RS
Sbjct: 44 VYQMLLNEMVPLAMGIERQISGDVISSDSNVTSENGNINNMIKRLKIEEHHTVDIIRSHN 103
Query: 234 ALSNL 238
+ L
Sbjct: 104 LIHEL 108
>YDL006w [T] KOG0698 Serine/threonine protein phosphatase
Length = 281
Score = 28.5 bits (62), Expect = 8.8
Identities = 21/88 (23%), Positives = 37/88 (41%), Gaps = 10/88 (11%)
Query: 59 QDIQHKFDLYKTRLDYAYVPIIISNAGFIIFGWCIGTKQHLAVILVMSGLA-------SL 111
+D+ + +RLD+ Y + +AG WC +HL I+ + LA +
Sbjct: 36 EDVHTYVKNFASRLDWGYFAVFDGHAGIQASKWC---GKHLHTIIEQNILADETRDVRDV 92
Query: 112 MCNCMISISNTLVVDLYPERASTAAGCV 139
+ + ++I + L TAA CV
Sbjct: 93 LNDSFLAIDEEINTKLVGNSGCTAAVCV 120
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.326 0.138 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,171,340
Number of Sequences: 60738
Number of extensions: 513628
Number of successful extensions: 2201
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2190
Number of HSP's gapped (non-prelim): 18
length of query: 241
length of database: 30,389,216
effective HSP length: 103
effective length of query: 138
effective length of database: 24,133,202
effective search space: 3330381876
effective search space used: 3330381876
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)