ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI0993 good R KOG0504 General function prediction only FOG: Ankyrin repeat
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI0993 342770 345649 960
(960 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIL112w [R] KOG0504 FOG: Ankyrin repeat 476 e-134
Hs13376842 [M] KOG4177 Ankyrin 101 5e-21
Hs10947054 [M] KOG4177 Ankyrin 101 5e-21
Hs10947052 [M] KOG4177 Ankyrin 101 5e-21
7301689 [R] KOG0504 FOG: Ankyrin repeat 101 6e-21
Hs14731279 [R] KOG0504 FOG: Ankyrin repeat 100 1e-20
Hs10947056 [M] KOG4177 Ankyrin 100 1e-20
Hs4507613 [M] KOG4177 Ankyrin 99 3e-20
7301359 [M] KOG4177 Ankyrin 96 3e-19
CE06705 [M] KOG4177 Ankyrin 95 6e-19
CE06704 [M] KOG4177 Ankyrin 95 6e-19
CE06703 [M] KOG4177 Ankyrin 95 6e-19
CE06702 [M] KOG4177 Ankyrin 95 6e-19
7301132 [R] KOG0504 FOG: Ankyrin repeat 95 6e-19
Hs4502093 [M] KOG4177 Ankyrin 93 2e-18
CE23926 [T] KOG4369 RTK signaling protein MASK/UNC-44 92 3e-18
CE06305 [T] KOG4369 RTK signaling protein MASK/UNC-44 92 3e-18
7295202 [M] KOG4177 Ankyrin 91 7e-18
Hs4557349_2 [R] KOG0504 FOG: Ankyrin repeat 90 1e-17
Hs13386462 [R] KOG0504 FOG: Ankyrin repeat 90 2e-17
7304338 [M] KOG4177 Ankyrin 88 7e-17
Hs7657238 [R] KOG0504 FOG: Ankyrin repeat 87 2e-16
Hs10947042 [M] KOG4177 Ankyrin 84 8e-16
Hs10947040 [M] KOG4177 Ankyrin 84 8e-16
Hs10947038 [M] KOG4177 Ankyrin 84 8e-16
Hs10947036 [M] KOG4177 Ankyrin 84 8e-16
7301133 [T] KOG4369 RTK signaling protein MASK/UNC-44 81 7e-15
CE26238_1 [M] KOG4177 Ankyrin 79 4e-14
Hs4505319 [OT] KOG0505 Myosin phosphatase regulatory subunit 77 1e-13
Hs14195601 [OT] KOG0505 Myosin phosphatase regulatory subunit 77 1e-13
7300995 [T] KOG0507 CASK-interacting adaptor protein (caskin) an... 77 1e-13
Hs20472035 [R] KOG0504 FOG: Ankyrin repeat 76 3e-13
Hs15718772_1 [R] KOG0504 FOG: Ankyrin repeat 75 4e-13
7294199_2 [R] KOG0504 FOG: Ankyrin repeat 75 4e-13
Hs7705748 [T] KOG0192 Tyrosine kinase specific for activated (GT... 75 5e-13
7295200_2 [R] KOG0504 FOG: Ankyrin repeat 75 6e-13
7291279 [R] KOG0502 Integral membrane ankyrin-repeat protein Kid... 74 8e-13
Hs4505317 [OT] KOG0505 Myosin phosphatase regulatory subunit 74 1e-12
Hs20538133 [R] KOG0504 FOG: Ankyrin repeat 74 1e-12
Hs16159328 [R] KOG0504 FOG: Ankyrin repeat 72 3e-12
7295892 [M] KOG4177 Ankyrin 72 4e-12
Hs20556512 [T] KOG0507 CASK-interacting adaptor protein (caskin)... 71 9e-12
Hs22064845 [T] KOG0192 Tyrosine kinase specific for activated (G... 70 2e-11
Hs14770818 [OT] KOG0505 Myosin phosphatase regulatory subunit 70 2e-11
HsM11545809 [M] KOG4177 Ankyrin 69 3e-11
Hs21314697 [M] KOG4177 Ankyrin 69 3e-11
CE28044 [OT] KOG0505 Myosin phosphatase regulatory subunit 69 3e-11
CE11616 [OT] KOG0505 Myosin phosphatase regulatory subunit 69 3e-11
SPAC2F7.10 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger do... 68 6e-11
Hs7657265 [R] KOG0508 Ankyrin repeat protein 68 6e-11
CE16523 [R] KOG0504 FOG: Ankyrin repeat 68 6e-11
Hs10863929_1 [M] KOG4177 Ankyrin 68 6e-11
Hs22059561 [R] KOG0504 FOG: Ankyrin repeat 68 8e-11
Hs16076877 [R] KOG0504 FOG: Ankyrin repeat 68 8e-11
CE05814 [R] KOG0502 Integral membrane ankyrin-repeat protein Kid... 67 1e-10
7301236 [T] KOG0507 CASK-interacting adaptor protein (caskin) an... 67 1e-10
Hs17864094 [R] KOG0508 Ankyrin repeat protein 67 2e-10
At3g02850 [PT] KOG0498 K+-channel ERG and related proteins conta... 67 2e-10
Hs7705831 [R] KOG0504 FOG: Ankyrin repeat 66 2e-10
Hs14149803 [U] KOG2319 Vacuolar assembly/sorting protein VPS9 66 2e-10
7298524_2 [R] KOG0504 FOG: Ankyrin repeat 66 3e-10
Hs14738291 [R] KOG0504 FOG: Ankyrin repeat 65 4e-10
7299952 [R] KOG0508 Ankyrin repeat protein 65 5e-10
Hs19718743 [T] KOG2209 Oxysterol-binding protein 65 7e-10
Hs19718741 [T] KOG2209 Oxysterol-binding protein 65 7e-10
Hs14764060 [R] KOG0508 Ankyrin repeat protein 65 7e-10
At2g25600 [PT] KOG0498 K+-channel ERG and related proteins conta... 64 9e-10
YDR264c [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domai... 64 1e-09
At5g13300 [T] KOG0521 Putative GTPase activating proteins (GAPs) 64 1e-09
Hs22060186 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger do... 64 1e-09
Hs14150037 [R] KOG0504 FOG: Ankyrin repeat 64 1e-09
At2g31820 [R] KOG0504 FOG: Ankyrin repeat 64 1e-09
Hs18252778 [R] KOG0504 FOG: Ankyrin repeat 63 2e-09
At2g26650 [PT] KOG0498 K+-channel ERG and related proteins conta... 63 2e-09
Hs9506623 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger dom... 62 3e-09
Hs21314722 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 62 3e-09
Hs17449525 [K] KOG4214 Myotrophin and similar proteins 62 3e-09
7293339 [R] KOG0504 FOG: Ankyrin repeat 62 3e-09
Hs4758606 [T] KOG0195 Integrin-linked kinase 62 4e-09
7298956 [R] KOG0510 Ankyrin repeat protein 62 4e-09
7294194 [OT] KOG0505 Myosin phosphatase regulatory subunit 62 4e-09
Hs20543919 [R] KOG0504 FOG: Ankyrin repeat 62 6e-09
CE28922 [K] KOG0512 Fetal globin-inducing factor (contains ankyr... 62 6e-09
7293882 [OT] KOG0505 Myosin phosphatase regulatory subunit 62 6e-09
Hs18561834 [M] KOG4177 Ankyrin 61 7e-09
Hs18079216 [T] KOG0507 CASK-interacting adaptor protein (caskin)... 61 7e-09
At5g37500 [PT] KOG0498 K+-channel ERG and related proteins conta... 61 7e-09
At4g35450 [R] KOG0504 FOG: Ankyrin repeat 61 7e-09
Hs22047757 [M] KOG4177 Ankyrin 61 9e-09
Hs18593188 [R] KOG0508 Ankyrin repeat protein 60 1e-08
At3g12360 [R] KOG0504 FOG: Ankyrin repeat 60 1e-08
7296935 [R] KOG0504 FOG: Ankyrin repeat 60 1e-08
Hs10190676_2 [R] KOG0504 FOG: Ankyrin repeat 60 2e-08
Hs13899329 [R] KOG0504 FOG: Ankyrin repeat 60 2e-08
At3g04710_1 [R] KOG0504 FOG: Ankyrin repeat 60 2e-08
CE07175 [R] KOG0508 Ankyrin repeat protein 59 3e-08
7302342 [R] KOG0508 Ankyrin repeat protein 59 3e-08
7301583 [R] KOG0504 FOG: Ankyrin repeat 59 3e-08
Hs7706007 [R] KOG0504 FOG: Ankyrin repeat 59 4e-08
Hs13129098 [R] KOG0504 FOG: Ankyrin repeat 59 4e-08
CE17993 [R] KOG0504 FOG: Ankyrin repeat 59 5e-08
At4g27780 [I] KOG0817 Acyl-CoA-binding protein 59 5e-08
At2g03430 [O] KOG4412 26S proteasome regulatory complex subunit ... 59 5e-08
7297584 [R] KOG0502 Integral membrane ankyrin-repeat protein Kid... 59 5e-08
Hs12746412 [R] KOG0502 Integral membrane ankyrin-repeat protein ... 58 6e-08
Hs14744423 [R] KOG0504 FOG: Ankyrin repeat 57 1e-07
Hs13540484 [R] KOG0504 FOG: Ankyrin repeat 57 1e-07
At5g07840 [R] KOG0504 FOG: Ankyrin repeat 57 1e-07
At3g09890 [R] KOG0504 FOG: Ankyrin repeat 57 1e-07
CE28110 [T] KOG0521 Putative GTPase activating proteins (GAPs) 57 2e-07
CE27723 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 57 2e-07
CE25223 [T] KOG0521 Putative GTPase activating proteins (GAPs) 57 2e-07
CE20486 [OT] KOG0505 Myosin phosphatase regulatory subunit 57 2e-07
7296403 [T] KOG0195 Integrin-linked kinase 57 2e-07
Hs8923181 [K] KOG0512 Fetal globin-inducing factor (contains ank... 56 2e-07
Hs4506217 [O] KOG4412 26S proteasome regulatory complex subunit ... 56 2e-07
At4g32500 [PT] KOG0498 K+-channel ERG and related proteins conta... 56 2e-07
7290390 [T] KOG1217 Fibrillins and related proteins containing C... 56 3e-07
7294632_2 [R] KOG0504 FOG: Ankyrin repeat 56 3e-07
CE19848_2 [R] KOG0504 FOG: Ankyrin repeat 56 3e-07
Hs7662406 [R] KOG0504 FOG: Ankyrin repeat 55 4e-07
Hs22004647 [R] KOG0504 FOG: Ankyrin repeat 55 4e-07
Hs13443014 [R] KOG0504 FOG: Ankyrin repeat 55 4e-07
At2g17390 [R] KOG0504 FOG: Ankyrin repeat 55 4e-07
CE05333 [R] KOG0510 Ankyrin repeat protein 55 5e-07
Hs7706377 [R] KOG0504 FOG: Ankyrin repeat 55 7e-07
7303116 [R] KOG0514 Ankyrin repeat protein 55 7e-07
Hs14150169 [I] KOG0817 Acyl-CoA-binding protein 54 9e-07
CE06954 [K] KOG4214 Myotrophin and similar proteins 54 9e-07
Hs13375989 [R] KOG0504 FOG: Ankyrin repeat 54 1e-06
7294202 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domai... 54 1e-06
SPBP16F5.05c [R] KOG0504 FOG: Ankyrin repeat 54 2e-06
SPAC6C3.08 [O] KOG4412 26S proteasome regulatory complex subunit... 54 2e-06
Hs4885643 [D] KOG0515 p53-interacting protein 53BP/ASPP contains... 54 2e-06
Hs22057484 [R] KOG0504 FOG: Ankyrin repeat 54 2e-06
Hs21450703 [R] KOG0504 FOG: Ankyrin repeat 54 2e-06
Hs20562143 [R] KOG0504 FOG: Ankyrin repeat 54 2e-06
Hs18570215 [R] KOG0508 Ankyrin repeat protein 54 2e-06
Hs18254476 [R] KOG0504 FOG: Ankyrin repeat 54 2e-06
At3g58760 [T] KOG0192 Tyrosine kinase specific for activated (GT... 54 2e-06
SPAPB1E7.05_1 [R] KOG0504 FOG: Ankyrin repeat 54 2e-06
HsM13376093 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV... 53 2e-06
Hs18254462 [R] KOG0504 FOG: Ankyrin repeat 53 2e-06
At1g05640 [R] KOG0504 FOG: Ankyrin repeat 53 2e-06
7295029 [R] KOG0510 Ankyrin repeat protein 53 2e-06
SPCP1E11.10 [R] KOG0504 FOG: Ankyrin repeat 53 3e-06
Hs18426879 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 53 3e-06
Hs18375637 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 53 3e-06
CE19706 [T] KOG0195 Integrin-linked kinase 53 3e-06
At5g53470 [I] KOG0817 Acyl-CoA-binding protein 53 3e-06
Hs18254470 [R] KOG0504 FOG: Ankyrin repeat 52 3e-06
CE27420 [R] KOG0504 FOG: Ankyrin repeat 52 3e-06
Hs7706379 [R] KOG0504 FOG: Ankyrin repeat 52 4e-06
Hs4557799 [T] KOG1217 Fibrillins and related proteins containing... 52 4e-06
7296976 [M] KOG4177 Ankyrin 52 4e-06
7294864 [R] KOG0504 FOG: Ankyrin repeat 52 4e-06
7293542 [K] KOG4214 Myotrophin and similar proteins 52 4e-06
Hs4885087 [R] KOG0504 FOG: Ankyrin repeat 51 1e-05
Hs22044723 [R] KOG0504 FOG: Ankyrin repeat 51 1e-05
CE17314 [K] KOG1015 Transcription regulator XNP/ATRX DEAD-box su... 51 1e-05
At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 51 1e-05
At1g07710 [R] KOG0504 FOG: Ankyrin repeat 51 1e-05
>YIL112w [R] KOG0504 FOG: Ankyrin repeat
Length = 1083
Score = 476 bits (1225), Expect = e-134
Identities = 335/984 (34%), Positives = 483/984 (49%), Gaps = 99/984 (10%)
Query: 41 NGNYSVTNVPVKEEEVSQKVTSTDQNSTKQPSDEPYVVS--QANSSDQKVGSPLNNQESI 98
NG+ +VP E++SQ + + +S+ P+ + Q S DQ + + L +
Sbjct: 105 NGDSRPDDVPETNEKISQAIRAKISSSSSSPNVRNVDIQNHQPFSRDQ-LRAMLKEPKRK 163
Query: 99 PVR---QAETKGPINEIKQETDVEEKKNLPKVGRNKHSDEEYSSA---LSEVESDAPTEP 152
V + E G + E +V EK N D EYS + +V SD PT P
Sbjct: 164 TVDDFIEEEGLGAVEEEDLSDEVLEKNTTEP--ENVEKDIEYSDSDKDTDDVGSDDPTAP 221
Query: 153 ASPPRPKMGRLIRGDQLESGNNSRQSSAPVLTNDGEXXXXXXXXXEARTAKISSSAIHED 212
SP + +L+RGDQL++ +S ++ E +++ +SSS
Sbjct: 222 NSPIKLGRRKLVRGDQLDATTSSMFNN--------ESDSELSDIDDSKNIALSSSLFRGG 273
Query: 213 SSPVKHYNEH----------KRKSSSIENSSNHKKQKHSAGKKIPKTKRGVHRDAGGRTK 262
SSPVK N + K S+ S++ K H A K PK K+G++RD+GGRT+
Sbjct: 274 SSPVKETNNNLSNMNSSPAQNPKRGSVSRSNDSNKSSHIAVSKRPKQKKGIYRDSGGRTR 333
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
LQIACDKGKYD+ KK+IEE GYD+NDQDNAGNT LHEAAL GH IVELL+ NGA+VNI+
Sbjct: 334 LQIACDKGKYDVVKKMIEEGGYDINDQDNAGNTALHEAALQGHIEIVELLIENGADVNIK 393
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDN-DDRRI 381
S +MF DTPLIDASANGH++VVKYLL +GADPT+ NAKGL+A ES+++ES+ D+ +D++I
Sbjct: 394 SIEMFGDTPLIDASANGHLDVVKYLLKNGADPTIRNAKGLTAFESVDDESEFDDEEDQKI 453
Query: 382 VHDMKDMLKRATRKYIKHS--HRTLQSSSMSRHS------DDIDKQLNH----------- 422
+ ++K L A +K+ + H + + H+ D+ K N
Sbjct: 454 LREIKKRLSIAAKKWTNRAGIHNDKSKNGNNAHTIDQPPFDNTTKAKNEKAADSPSMASN 513
Query: 423 ------DDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHD 476
+++FYWTD++S+ GK KL KASKEG L YVG+Y+ENGG+ D R F ES GH+
Sbjct: 514 IDEKAPEEEFYWTDVTSRAGKEKLFKASKEGHLPYVGTYVENGGKIDLRSFFESVKCGHE 573
Query: 477 DVVSLFLAFGAQVNMSNKEGQT-PLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHY 535
D+ S+FLAFG VN ++++ +T LM++VGRGH+ VKLLLEAGADP K DK+ +TAL+Y
Sbjct: 574 DITSIFLAFGFPVNQTSRDNKTSALMVAVGRGHLGTVKLLLEAGADPTKRDKKGRTALYY 633
Query: 536 ANHSSLGLTDPDEVNLLKAAVRAKYGYEVXXXXXXXXXXXXXXXXXXXXXXXXXXXTKGE 595
A +S +G+T+ +E+ L++ A+ +
Sbjct: 634 AKNSIMGITNSEEIQLIENAINNYLKKHSEDNNDDDDDDDNNNETYKHEKKREKTQSPIL 693
Query: 596 EQDRS----LEIRKDDSPYHSEPQSKIGNINEEKPKLLPDSQTTAETASLVRPSLERLDX 651
RS +E +DD+ + N + K DS+ + V
Sbjct: 694 ASRRSATPRIEDEEDDTRMLNLADDDFNNDRDVKESTTSDSRKRLDDNENVGTQYSLDWK 753
Query: 652 XXXXXXXXXXHRYKSASPTHQLSTPPILPK------------ESEEERAARLKSXXXXXX 699
+ KS SP LS P PK E+ ER ARLK
Sbjct: 754 KRKTNALQDEEKLKSISP---LSMEPHSPKKAKSVEISKIHEETAAEREARLKEEEEYRK 810
Query: 700 XXXXXXXXXXXXFLNRLAEDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 759
L +LAED
Sbjct: 811 KRLEKKRKKEQELLQKLAEDEKKRIEEQEKQKVLEMERLEKATLEKARKMEREKEMEEIS 870
Query: 760 XXXKIRERYPIGLRVIDFKDLENYDKFGPVYYFT-EDGSKWVLDLQISVIIK--SSTEEL 816
+R+ YP+GL++I+F D +Y +F P+YYF E K+VLDLQ+ +++K +
Sbjct: 871 YRRAVRDLYPLGLKIINFNDKLDYKRFLPLYYFVDEKNDKFVLDLQVMILLKDIDLLSKD 930
Query: 817 KKQSSEFKEVEKGQYPQLWNLFKFIFLYGGS--DNANNSKSLPWRQLSEIDQT------- 867
+ +SE V+ LWN+ KFIFLYGGS D NN ++ R + D
Sbjct: 931 NQPTSEKIPVDPSHLTPLWNMLKFIFLYGGSYDDKKNNMENK--RYVVNFDGVDLDTKIG 988
Query: 868 ----EYVKFYELPLTWIKLSRLNLQDLNPKMNDWIEKNMIEFIPASTSALYRTRKVLLRD 923
EY KF LP+ WIK + ++ N IE NMI+ S + R R L
Sbjct: 989 YELLEYKKFVSLPMAWIKWDNVVIE--NHAKRKEIEGNMIQI---SINEFARWRNDKLNK 1043
Query: 924 SKRPGQNENNAN-TRFVPAKYQSR 946
+++P + + + R +P K+Q R
Sbjct: 1044 AQQPTRKQRSLKIPRELPVKFQHR 1067
>Hs13376842 [M] KOG4177 Ankyrin
Length = 1166
Score = 101 bits (252), Expect = 5e-21
Identities = 88/303 (29%), Positives = 136/303 (44%), Gaps = 28/303 (9%)
Query: 255 RDAGGR--TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELL 312
RD GR T L A + + + L++ G DV+ +D G PLH A GH + ELL
Sbjct: 520 RDIEGRQSTPLHFAAGYNRVSVVEYLLQH-GADVHAKDKGGLVPLHNACSYGHYEVAELL 578
Query: 313 VRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEES 372
V++GA VN+ D++ TPL +A+A G + K LL HGADPT N G + ++ ++
Sbjct: 579 VKHGAVVNVA--DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK--- 633
Query: 373 DMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDIS 432
D D D + ++ +L A + + + +++ D Q H T +
Sbjct: 634 DGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR----DTQGRHS-----TPLH 684
Query: 433 SKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
G N L A L G+ + + + YGH DV +L + + A VN +
Sbjct: 685 LAAGYNNLEVAE---YLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT 741
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTDPDEVNLL 552
+K TPL + +G + LLL GADP T + + L L D+V+ L
Sbjct: 742 DKWAFTPLHEAAQKGRTQLCALLLAHGADP--------TLKNQEGQTPLDLVSADDVSAL 793
Query: 553 KAA 555
A
Sbjct: 794 LTA 796
Score = 97.4 bits (241), Expect = 9e-20
Identities = 83/295 (28%), Positives = 137/295 (46%), Gaps = 20/295 (6%)
Query: 244 KKIPKTKRGVHRDAGGR--TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAA 301
K++ ++ RD GR T L A G+ D+ + L++ +G +V +D+ G PLH A
Sbjct: 41 KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQ-NGANVQARDDGGLIPLHNAC 99
Query: 302 LNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
GH+ +V LL+R+GA+ N + D + TPL +A+ G I+V LL HGA+PT+ N G
Sbjct: 100 SFGHAEVVNLLLRHGADPNAR--DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDG 157
Query: 362 LSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLN 421
+A++ + + + ++L+ A + L +++ H+ D K
Sbjct: 158 RTALDLADPSAKAVLTGE---YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKS-- 212
Query: 422 HDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSL 481
T + G N++ L G+ + + D +C YGH +V L
Sbjct: 213 -------TPLHLAAGYNRVKIVQL---LLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262
Query: 482 FLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ GA VN + TPL + + V V LLL GADP + K+A+ A
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
Score = 82.0 bits (201), Expect = 4e-15
Identities = 68/275 (24%), Positives = 127/275 (45%), Gaps = 23/275 (8%)
Query: 277 KLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDAS 336
+L+ G ++N++ TPLH A+ H+ +VE++V++ A VN + D T L A+
Sbjct: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVN--ALDNLGQTSLHRAA 441
Query: 337 ANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKY 396
GH+ + LL +G DP +++ +G +A++ M N+ +++ +L+
Sbjct: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTALQ-------MGNE------NVQQLLQEGISLG 488
Query: 397 IKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYL 456
+ R L ++ + + + K+L DI + L A+ +++ V L
Sbjct: 489 NSEADRQLLEAAKAGDVETV-KKLCTVQSVNCRDIEGR-QSTPLHFAAGYNRVSVVEYLL 546
Query: 457 ENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVN 510
++G + +C YGH +V L + GA VN+++ TPL + +G
Sbjct: 547 QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYE 606
Query: 511 VVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTD 545
+ KLLL+ GADP K ++ T L + D
Sbjct: 607 ICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQD 641
>Hs10947054 [M] KOG4177 Ankyrin
Length = 1872
Score = 101 bits (252), Expect = 5e-21
Identities = 93/317 (29%), Positives = 134/317 (41%), Gaps = 43/317 (13%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G L +A +G L ++L+ G V+ GNT LH A+L G + +V++LV+ GAN
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESD----- 373
+N QS + F TPL A+ HI+VVKYLL++GA+ + G + + ++
Sbjct: 123 INAQSQNGF--TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 374 --MDNDDRRIVH-------DMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDD 424
++ND + V KD K A + +QS M + + H
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
Query: 425 DFYW--------------TDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPD------- 463
Y D +++ G L ASK G V L+ GG+ D
Sbjct: 241 AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL 300
Query: 464 --FRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
C S GHD VV L L GA + K G +PL ++ HV VK LL+ A
Sbjct: 301 TPLHCAARS---GHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 522 PQKTDKRKKTALHYANH 538
TALH A H
Sbjct: 358 VDDVTLDYLTALHVAAH 374
Score = 84.0 bits (206), Expect = 1e-15
Identities = 78/292 (26%), Positives = 127/292 (42%), Gaps = 21/292 (7%)
Query: 254 HRDAG---GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVE 310
H DA G T L I+ +G+ D+A L+E G + G TPLH AA G + +
Sbjct: 522 HPDAATTNGYTPLHISAREGQVDVASVLLEA-GAAHSLATKKGFTPLHVAAKYGSLDVAK 580
Query: 311 LLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEE 370
LL++ A + + TPL A+ + V LL+ GA P G + + +
Sbjct: 581 LLLQRRAAADSAGKNGL--TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Query: 371 ESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTD 430
++ M + + + T K L +S H+D + L+ + +
Sbjct: 639 KNQMQIASTLLNYGAE------TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH--- 689
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGRPD------FRCFLESCIYGHDDVVSLFLA 484
+S+K G L A++E K+ ++G D + + +C YG+ +V+ L
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749
Query: 485 FGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
GA VN K G TPL + +GH +++ +LL+ GA P T TAL A
Sbjct: 750 QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 79.0 bits (193), Expect = 3e-14
Identities = 82/292 (28%), Positives = 133/292 (45%), Gaps = 18/292 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G ++A L+ G V+ G TPLH A+ G++ +V+LL+ G
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
++ ++ D TPL A+ +GH VV+ LL+ GA GLS + + ++
Sbjct: 292 IDAKTRDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHD----DDFYWTDISSK 434
+ H K + T Y+ H +DK+ N + + F I+ K
Sbjct: 350 HLLQH--KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACK 407
Query: 435 LGKNKLLKAS-KEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSN 493
+ K+++ K G A + + E+G P + GH ++V L L GA +++N
Sbjct: 408 KNRIKVMELLVKYG--ASIQAITESGLTP----IHVAAFMGHLNIVLLLLQNGASPDVTN 461
Query: 494 KEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTD 545
G+T L ++ G V VV+ LL GA + ++T LH A S LG T+
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA--SRLGKTE 511
Score = 69.7 bits (169), Expect = 2e-11
Identities = 63/263 (23%), Positives = 115/263 (42%), Gaps = 18/263 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G D+AK L++ + N G TPLH AA + + LL+ GA+
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + + TPL A+ + + LL++GA+ +V +G++ + +E D
Sbjct: 622 PHATAKNGY--TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 679
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
++ D + +T+ + H Q ++ D H D D +KLG
Sbjct: 680 --LLLDKGANIHMSTKSGLTSLHLAAQEDKVNV----ADILTKHGAD---QDAHTKLGYT 730
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQVNMS 492
L+ A G + V L+ G + + ++ GH ++++ L GA+ N +
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 790
Query: 493 NKEGQTPLMLSVGRGHVNVVKLL 515
G T L ++ G+++VV L
Sbjct: 791 TANGNTALAIAKRLGYISVVDTL 813
Score = 69.3 bits (168), Expect = 3e-11
Identities = 71/289 (24%), Positives = 125/289 (42%), Gaps = 22/289 (7%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G+ ++ + L+ +G V+ + TPLH A+ G + IV+LL+++ A+
Sbjct: 464 GETALHMAARAGQVEVVRCLLR-NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + + TPL ++ G ++V LL+ GA ++ KG + + + +D
Sbjct: 523 PDAATTNGY--TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD--- 577
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ +L + L ++ H D+ L + ++K G
Sbjct: 578 ------VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 631
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQVNMS 492
L A+K+ ++ + L G + + GH D+V+L L GA ++MS
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKT----ALHYAN 537
K G T L L+ VNV +L + GAD K T A HY N
Sbjct: 692 TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740
>Hs10947052 [M] KOG4177 Ankyrin
Length = 3957
Score = 101 bits (252), Expect = 5e-21
Identities = 93/317 (29%), Positives = 134/317 (41%), Gaps = 43/317 (13%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G L +A +G L ++L+ G V+ GNT LH A+L G + +V++LV+ GAN
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESD----- 373
+N QS + F TPL A+ HI+VVKYLL++GA+ + G + + ++
Sbjct: 123 INAQSQNGF--TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 374 --MDNDDRRIVH-------DMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDD 424
++ND + V KD K A + +QS M + + H
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
Query: 425 DFYW--------------TDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPD------- 463
Y D +++ G L ASK G V L+ GG+ D
Sbjct: 241 AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL 300
Query: 464 --FRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
C S GHD VV L L GA + K G +PL ++ HV VK LL+ A
Sbjct: 301 TPLHCAARS---GHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 522 PQKTDKRKKTALHYANH 538
TALH A H
Sbjct: 358 VDDVTLDYLTALHVAAH 374
Score = 84.0 bits (206), Expect = 1e-15
Identities = 78/292 (26%), Positives = 127/292 (42%), Gaps = 21/292 (7%)
Query: 254 HRDAG---GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVE 310
H DA G T L I+ +G+ D+A L+E G + G TPLH AA G + +
Sbjct: 522 HPDAATTNGYTPLHISAREGQVDVASVLLEA-GAAHSLATKKGFTPLHVAAKYGSLDVAK 580
Query: 311 LLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEE 370
LL++ A + + TPL A+ + V LL+ GA P G + + +
Sbjct: 581 LLLQRRAAADSAGKNGL--TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Query: 371 ESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTD 430
++ M + + + T K L +S H+D + L+ + +
Sbjct: 639 KNQMQIASTLLNYGAE------TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH--- 689
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGRPD------FRCFLESCIYGHDDVVSLFLA 484
+S+K G L A++E K+ ++G D + + +C YG+ +V+ L
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749
Query: 485 FGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
GA VN K G TPL + +GH +++ +LL+ GA P T TAL A
Sbjct: 750 QGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 79.0 bits (193), Expect = 3e-14
Identities = 82/292 (28%), Positives = 133/292 (45%), Gaps = 18/292 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G ++A L+ G V+ G TPLH A+ G++ +V+LL+ G
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
++ ++ D TPL A+ +GH VV+ LL+ GA GLS + + ++
Sbjct: 292 IDAKTRDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHD----DDFYWTDISSK 434
+ H K + T Y+ H +DK+ N + + F I+ K
Sbjct: 350 HLLQH--KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACK 407
Query: 435 LGKNKLLKAS-KEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSN 493
+ K+++ K G A + + E+G P + GH ++V L L GA +++N
Sbjct: 408 KNRIKVMELLVKYG--ASIQAITESGLTP----IHVAAFMGHLNIVLLLLQNGASPDVTN 461
Query: 494 KEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTD 545
G+T L ++ G V VV+ LL GA + ++T LH A S LG T+
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIA--SRLGKTE 511
Score = 69.7 bits (169), Expect = 2e-11
Identities = 63/263 (23%), Positives = 115/263 (42%), Gaps = 18/263 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G D+AK L++ + N G TPLH AA + + LL+ GA+
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + + TPL A+ + + LL++GA+ +V +G++ + +E D
Sbjct: 622 PHATAKNGY--TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 679
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
++ D + +T+ + H Q ++ D H D D +KLG
Sbjct: 680 --LLLDKGANIHMSTKSGLTSLHLAAQEDKVNV----ADILTKHGAD---QDAHTKLGYT 730
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQVNMS 492
L+ A G + V L+ G + + ++ GH ++++ L GA+ N +
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 790
Query: 493 NKEGQTPLMLSVGRGHVNVVKLL 515
G T L ++ G+++VV L
Sbjct: 791 TANGNTALAIAKRLGYISVVDTL 813
Score = 69.3 bits (168), Expect = 3e-11
Identities = 71/289 (24%), Positives = 125/289 (42%), Gaps = 22/289 (7%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G+ ++ + L+ +G V+ + TPLH A+ G + IV+LL+++ A+
Sbjct: 464 GETALHMAARAGQVEVVRCLLR-NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + + TPL ++ G ++V LL+ GA ++ KG + + + +D
Sbjct: 523 PDAATTNGY--TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD--- 577
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ +L + L ++ H D+ L + ++K G
Sbjct: 578 ------VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 631
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQVNMS 492
L A+K+ ++ + L G + + GH D+V+L L GA ++MS
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKT----ALHYAN 537
K G T L L+ VNV +L + GAD K T A HY N
Sbjct: 692 TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740
>7301689 [R] KOG0504 FOG: Ankyrin repeat
Length = 2119
Score = 101 bits (251), Expect = 6e-21
Identities = 85/289 (29%), Positives = 124/289 (42%), Gaps = 47/289 (16%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
H D G T L+ A G ++ + LI + ++ D G T L AA +GH I++LL+
Sbjct: 1311 HADRDGWTPLRSASWGGHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLI 1370
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESD 373
+GA+VN S D T LI AS GH ++V+ LL++GA+ ++ G SA+
Sbjct: 1371 ESGADVN--SVDRQGRTSLIAASYMGHYDIVEILLENGANVNHLDLDGRSAL-------- 1420
Query: 374 MDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISS 433
S +S I L+H + TD
Sbjct: 1421 ----------------------------CVAALCGSSGYSKVISTLLDHGAN---TDQLD 1449
Query: 434 KLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFL------ESCIYGHDDVVSLFLAFGA 487
G + LL +S EG LEN PD F+ +C GH VV L L +G
Sbjct: 1450 NDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHATVVKLLLFWGC 1509
Query: 488 QVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
++ + EG+T L + +G+V V+ LL+ G D D T LHYA
Sbjct: 1510 GIDCMDSEGRTVLSIGAAQGNVETVRQLLDRGLDETHRDNAGWTPLHYA 1558
Score = 82.4 bits (202), Expect = 3e-15
Identities = 84/296 (28%), Positives = 131/296 (43%), Gaps = 26/296 (8%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D+ GRT L I +G + ++L++ G D +DNAG TPLH AA G + L+ +
Sbjct: 1515 DSEGRTVLSIGAAQGNVETVRQLLDR-GLDETHRDNAGWTPLHYAAFEGFHEVCLQLLES 1573
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLD-HGADPTMVNAKGLSAIESIEEESDM 374
GA ++ D T L A+ G ++ V+ LLD H + G +A E M
Sbjct: 1574 GAKID--ECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHM 1631
Query: 375 DNDDRRIVH----DMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTD 430
D + + + KD R T YI L+ ++D +
Sbjct: 1632 DTVEFLLKFCCDVNSKDADSRTTL-YILALENKLEIVKYLLDMTNVD-----------VN 1679
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGRP-----DFRCFLESCIY-GHDDVVSLFLA 484
I G+ L A+ +G V + +E G + R L SC + G+ DV+++ L
Sbjct: 1680 IPDSEGRTALHVAAWQGHADMVKTLIEAGADVNSMDLEARTPLHSCAWQGNHDVMNILLY 1739
Query: 485 FGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSS 540
+GA + + K+G T L +S GH V LL+ GA+P K+D +T + A SS
Sbjct: 1740 YGALADHACKQGATALGISAQEGHEKCVIALLQFGANPYKSDHCGRTPIKLAAKSS 1795
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/111 (36%), Positives = 61/111 (54%), Gaps = 2/111 (1%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+DA RT L I + K ++ K L++ DVN D+ G T LH AA GH+ +V+ L+
Sbjct: 1647 KDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAAWQGHADMVKTLIE 1706
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
GA+VN S D+ TPL + G+ +V+ LL +GA +G +A+
Sbjct: 1707 AGADVN--SMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACKQGATAL 1755
Score = 52.0 bits (123), Expect = 4e-06
Identities = 25/66 (37%), Positives = 46/66 (68%), Gaps = 1/66 (1%)
Query: 474 GHDDVVSLFLAFGA-QVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTA 532
GH +VV L +A A ++++++KEG+T L + GH +++KLL+E+GAD D++ +T+
Sbjct: 1327 GHSEVVRLLIAQPACKIDLADKEGRTALRAAAWSGHEDILKLLIESGADVNSVDRQGRTS 1386
Query: 533 LHYANH 538
L A++
Sbjct: 1387 LIAASY 1392
>Hs14731279 [R] KOG0504 FOG: Ankyrin repeat
Length = 743
Score = 100 bits (249), Expect = 1e-20
Identities = 95/317 (29%), Positives = 148/317 (45%), Gaps = 47/317 (14%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
H D G T L +A +G D+ L+E G DV+ DN G TPL AA GH+++V L+
Sbjct: 57 HCDKDGMTPLLVAAYEGHVDVVDLLLE-GGADVDHTDNNGRTPLLAAASMGHASVVNTLL 115
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI-------- 365
GA V+ S D T L ASA G++ VV+ LLD G D + G + +
Sbjct: 116 FWGAAVD--SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGH 173
Query: 366 ----ESIEEE----SDMDNDDR---------------RIVHDMKDMLKRATRKYIKHSHR 402
E++ E+ +++DND R +I+ + K + + R Y
Sbjct: 174 RLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQ--RGY--DGRN 229
Query: 403 TLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRP 462
L+ +++ H D ++ +H D D G+ L + E +L +LENG
Sbjct: 230 ALRVAALEGHRDIVELLFSHGADVNCKDAD---GRPTLYILALENQLTMAEYFLENGANV 286
Query: 463 DF-----RCFLE-SCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLL 516
+ R L SC GH ++V + +A+ A VN ++ E ++ L + +GHV VV+LL+
Sbjct: 287 EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLI 346
Query: 517 EAGADPQKTDKRKKTAL 533
E GA T + TAL
Sbjct: 347 EHGAVVDHTCNQGATAL 363
Score = 99.8 bits (247), Expect = 2e-20
Identities = 83/291 (28%), Positives = 133/291 (45%), Gaps = 26/291 (8%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D+ GRT L IA +G ++ + L++ G D N +D+AG TPLH AA GH I E L+
Sbjct: 125 DSEGRTVLSIASAQGNVEVVRTLLDR-GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 183
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
GA N D + P I AS GH + V+ LL++ ++ G +A+ E D
Sbjct: 184 GARTNEIDNDGRI--PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD 241
Query: 376 NDDRRIVH----DMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDI 431
+ H + KD R T + ++ + + +++
Sbjct: 242 IVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEA------------- 288
Query: 432 SSKLGKNKLLKASKEGKLAYVGSYLE-----NGGRPDFRCFLESCIY-GHDDVVSLFLAF 485
S G+ L + +G + V + N + R L+S + GH VV L +
Sbjct: 289 SDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH 348
Query: 486 GAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
GA V+ + +G T L ++ GH++VV++LLE GADP D+ +TA+ A
Sbjct: 349 GAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 399
Score = 82.0 bits (201), Expect = 4e-15
Identities = 83/310 (26%), Positives = 133/310 (42%), Gaps = 58/310 (18%)
Query: 270 GKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAAL-----NGHSAIVELLVRNGANVNIQSY 324
G ++ + L++ G +VN +D G T L AAL GH+++V LL+ GA V+
Sbjct: 2 GHREIVEHLLDH-GAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDK 60
Query: 325 DMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG---LSAIESIEEESDMDNDDRRI 381
D TPL+ A+ GH++VV LL+ GAD + G L A S+ S +
Sbjct: 61 DGM--TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHAS--------V 110
Query: 382 VHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQL-------NHDDDFYWTDISSK 434
V+ + + A I RT+ S + ++ + ++ + L NH DD WT +
Sbjct: 111 VNTL--LFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMA 168
Query: 435 L------------------------GKNKLLKASKEGKLAYVGSYLENGGRPDFR----- 465
G+ + AS+EG V LEN D R
Sbjct: 169 AFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGR 228
Query: 466 -CFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQK 524
+ + GH D+V L + GA VN + +G+ L + + + + LE GA+ +
Sbjct: 229 NALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEA 288
Query: 525 TDKRKKTALH 534
+D +TALH
Sbjct: 289 SDAEGRTALH 298
Score = 57.0 bits (136), Expect = 1e-07
Identities = 54/204 (26%), Positives = 84/204 (40%), Gaps = 43/204 (21%)
Query: 339 GHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIK 398
GH +V++LLDHGA+ + G +A+ + + A++
Sbjct: 2 GHREIVEHLLDHGAEVNHEDVDGRTALS------------------VAALCVPASK---- 39
Query: 399 HSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLEN 458
H ++ S + R ++ D K G LL A+ EG + V LE
Sbjct: 40 -GHASVVSLLIDRGAE--------------VDHCDKDGMTPLLVAAYEGHVDVVDLLLEG 84
Query: 459 GGRPDFRC------FLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVV 512
G D L + GH VV+ L +GA V+ + EG+T L ++ +G+V VV
Sbjct: 85 GADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVV 144
Query: 513 KLLLEAGADPQKTDKRKKTALHYA 536
+ LL+ G D D T LH A
Sbjct: 145 RTLLDRGLDENHRDDAGWTPLHMA 168
Score = 53.9 bits (128), Expect = 1e-06
Identities = 40/133 (30%), Positives = 59/133 (44%), Gaps = 12/133 (9%)
Query: 412 HSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRC----- 466
H D ++NH+D D + L L + +G + V ++ G D C
Sbjct: 9 HLLDHGAEVNHED----VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKDGM 63
Query: 467 --FLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQK 524
L + GH DVV L L GA V+ ++ G+TPL+ + GH +VV LL GA
Sbjct: 64 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 123
Query: 525 TDKRKKTALHYAN 537
D +T L A+
Sbjct: 124 IDSEGRTVLSIAS 136
>Hs10947056 [M] KOG4177 Ankyrin
Length = 4377
Score = 100 bits (248), Expect = 1e-20
Identities = 97/367 (26%), Positives = 158/367 (42%), Gaps = 43/367 (11%)
Query: 209 IHEDSSPVKHYNEHKRKSSSIENSSNHKKQKHSAG-----KKIPKTKRGVHRDA---GGR 260
I+ + P K KR + S + +A K + K GV + G
Sbjct: 16 INAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGL 75
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
L +A +G ++ +L++ + +V+ GNT LH A+L G + +V++LV NGANVN
Sbjct: 76 NALHLASKEGHVEVVSELLQREA-NVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN 134
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE-SIEEESD------ 373
QS + F TPL A+ H+ VVK+LLD+GA ++ G + + ++++ D
Sbjct: 135 AQSQNGF--TPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Query: 374 MDNDDRRIVH-------DMKDMLKRATRKYIKHSHRTLQSSS------MSRHSDDIDKQL 420
++ND + V KD K A ++ ++S S ++ H +I+
Sbjct: 193 LENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT 252
Query: 421 NHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPD---------FRCFLESC 471
+ D +++ L ASK G V L+ G + D C S
Sbjct: 253 LLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARS- 311
Query: 472 IYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKT 531
GH+ VV + L A + K G +PL ++ H+N V+LLL+ T
Sbjct: 312 --GHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLT 369
Query: 532 ALHYANH 538
ALH A H
Sbjct: 370 ALHVAAH 376
Score = 93.2 bits (230), Expect = 2e-18
Identities = 79/286 (27%), Positives = 128/286 (44%), Gaps = 18/286 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G+ ++ + L++ DG V + TPLH +A G + IV+ L++ GA+
Sbjct: 466 GETALHMAARSGQAEVVRYLVQ-DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGAS 524
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N + + TPL ++ GH +V +LLDHGA ++ KG + + + ++
Sbjct: 525 PNAATTSGY--TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE--- 579
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ ++L + + L ++ H D+ L D ++K G
Sbjct: 580 ------VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Query: 439 KLLKASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
L A+K+ ++ + LE G R + GH D+VSL L A VN+S
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLS 693
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
NK G TPL L+ VNV ++L+ GA K T LH H
Sbjct: 694 NKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCH 739
Score = 80.9 bits (198), Expect = 9e-15
Identities = 74/313 (23%), Positives = 131/313 (41%), Gaps = 45/313 (14%)
Query: 260 RTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANV 319
+T L I+ GK D+ ++L+++ G N +G TPLH +A GH + L+ +GA++
Sbjct: 500 QTPLHISARLGKADIVQQLLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Query: 320 NIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDR 379
+I + F TPL A+ G + V LL A P +A G S + + + DN
Sbjct: 559 SITTKKGF--TPLHVAAKYGKLEVANLLLQKSASP---DAAGKSGLTPLHVAAHYDNQKV 613
Query: 380 RI---------------------VHDMKDMLKRAT---------RKYIKHSHRTLQSSSM 409
+ + K+ + AT + ++ ++
Sbjct: 614 ALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQ 673
Query: 410 SRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE 469
H D + L + + ++S+K G L A++E ++ + G D + +
Sbjct: 674 EGHVDMVSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 470 ------SCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQ 523
C YG+ +V+ L A+VN K G TPL + +GH +++ +LL+ A P
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Query: 524 KTDKRKKTALHYA 536
+ TAL A
Sbjct: 791 ELTVNGNTALGIA 803
Score = 80.1 bits (196), Expect = 2e-14
Identities = 83/298 (27%), Positives = 129/298 (42%), Gaps = 25/298 (8%)
Query: 253 VHRDAGGRTKL---QIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIV 309
+ D G+ +L IA K A L++ D + + + +G TPLH AA G+ +
Sbjct: 193 LENDTKGKVRLPALHIAARKDDTKAAALLLQNDN-NADVESKSGFTPLHIAAHYGNINVA 251
Query: 310 ELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIE 369
LL+ A V+ + + TPL AS G+ N+VK LLD GA GL+ +
Sbjct: 252 TLLLNRAAAVDFTARNDI--TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHC-- 307
Query: 370 EESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHD---DDF 426
+ ++V + D K K+ L ++ H + + L H+ DD
Sbjct: 308 ---GARSGHEQVVEMLLDRAAPILSK-TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDV 363
Query: 427 ---YWT--DISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSL 481
Y T +++ G K+ K + K A + NG P +C V+ L
Sbjct: 364 TNDYLTALHVAAHCGHYKVAKVLLDKK-ANPNAKALNGFTP----LHIACKKNRIKVMEL 418
Query: 482 FLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHS 539
L GA + + G TP+ ++ GHVN+V L+ GA P T+ R +TALH A S
Sbjct: 419 LLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARS 476
Score = 74.3 bits (181), Expect = 8e-13
Identities = 76/292 (26%), Positives = 129/292 (44%), Gaps = 18/292 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G ++A L+ V+ TPLH A+ G++ +V+LL+ GA
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAA-VDFTARNDITPLHVASKRGNANMVKLLLDRGAK 293
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
++ ++ D TPL + +GH VV+ LLD A GLS + + ++
Sbjct: 294 IDAKTRDGL--TPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQ 351
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHD----DDFYWTDISSK 434
+ H++ + T Y+ H +DK+ N + + F I+ K
Sbjct: 352 LLLQHNVP--VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACK 409
Query: 435 LGKNKLLKAS-KEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSN 493
+ K+++ K G A + + E+G P + GH ++VS + GA N +N
Sbjct: 410 KNRIKVMELLLKHG--ASIQAVTESGLTP----IHVAAFMGHVNIVSQLMHHGASPNTTN 463
Query: 494 KEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTD 545
G+T L ++ G VV+ L++ GA + K +T LH + + LG D
Sbjct: 464 VRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS--ARLGKAD 513
Score = 57.4 bits (137), Expect = 1e-07
Identities = 63/305 (20%), Positives = 126/305 (40%), Gaps = 22/305 (7%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A GK ++A L+++ + +G TPLH AA + + LL+ GA+
Sbjct: 565 GFTPLHVAAKYGKLEVANLLLQKSA-SPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS 623
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + + TPL A+ +++ LL++GAD V +G++++ +E +D
Sbjct: 624 PHAAAKNGY--TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD--- 678
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
M +L + L ++ D ++ + D +K+G
Sbjct: 679 ------MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYT 732
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQVNMS 492
L G + V L++ + + + ++ GH ++++ L A N
Sbjct: 733 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Query: 493 NKEGQTPLMLSVGRGHVNVV---KLLLEAGADPQKTDKRKKTALHYANHSSLGLTDPDEV 549
G T L ++ G+++VV K++ E ++ K + + L ++D DEV
Sbjct: 793 TVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSD-DEV 851
Query: 550 NLLKA 554
A
Sbjct: 852 RKANA 856
>Hs4507613 [M] KOG4177 Ankyrin
Length = 1327
Score = 99.0 bits (245), Expect = 3e-20
Identities = 82/284 (28%), Positives = 130/284 (44%), Gaps = 20/284 (7%)
Query: 255 RDAGGR--TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELL 312
RD GR T L A + + + L+ G DV+ +D G PLH A GH + ELL
Sbjct: 678 RDLEGRHSTPLHFAAGYNRVSVVEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEVAELL 736
Query: 313 VRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEES 372
VR+GA+VN+ D++ TPL +A+A G + K LL HGADPT N G + ++ ++E
Sbjct: 737 VRHGASVNVA--DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEG- 793
Query: 373 DMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDIS 432
D D + ++ +L A + + + +++ D Q + T +
Sbjct: 794 --DTDIQDLLKGDAALLDAAKKGCLARVQKLCTPENINCR----DTQGRNS-----TPLH 842
Query: 433 SKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
G N L A L G+ + + + YGH D+ +L + + VN +
Sbjct: 843 LAAGYNNLEVAE---YLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNAT 899
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+K TPL + +G + LLL GADP ++ +T L A
Sbjct: 900 DKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 95.5 bits (236), Expect = 3e-19
Identities = 80/281 (28%), Positives = 122/281 (42%), Gaps = 48/281 (17%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D T L +A + + + L++ G DV+ +D G PLH A GH + ELL+++
Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQH-GADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
GA VN + D++ TPL +A++ + V LL HGADPT+VN G SA++
Sbjct: 425 GACVN--AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVD--------- 473
Query: 376 NDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKL 435
+ ++ +R T ++ HS LQ+ +R +D
Sbjct: 474 ------MAPTPELRERLTYEFKGHS--LLQA---AREAD--------------------- 501
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKE 495
L K K L + C + S V L L GA VN NK+
Sbjct: 502 ----LAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKD 557
Query: 496 GQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
TPL ++ R H +V+++L + GA D +TALH A
Sbjct: 558 FMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRA 598
Score = 89.0 bits (219), Expect = 3e-17
Identities = 85/288 (29%), Positives = 130/288 (44%), Gaps = 28/288 (9%)
Query: 255 RDAGGR--TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELL 312
+D GR + L A G+ D+ + L++ G +V+ +D+ G PLH A GH+ +V LL
Sbjct: 210 KDMAGRKSSPLHFAAGFGRKDVVEHLLQM-GANVHARDDGGLIPLHNACSFGHAEVVSLL 268
Query: 313 VRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEES 372
+ GA+ N + D + TPL +A+ G I+V LL HGADP + N G SA+
Sbjct: 269 LCQGADPNAR--DNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSAL------- 319
Query: 373 DMDNDDRRIV---HDMKDMLKRATRKYIKHSHRTLQSS-SMSRHSDDIDKQLNHDDDFYW 428
D+ + + V KD L A R + L + +++ H+ D K
Sbjct: 320 DLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKS--------- 370
Query: 429 TDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQ 488
T + G N++ L G+ + + +C YGH +V L L GA
Sbjct: 371 TPLHLAAGYNRVRIVQ---LLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427
Query: 489 VNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
VN + TPL + + V V LLL GADP + K+A+ A
Sbjct: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 85.9 bits (211), Expect = 3e-16
Identities = 68/269 (25%), Positives = 123/269 (45%), Gaps = 11/269 (4%)
Query: 277 KLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDAS 336
+L+ G +VN+++ TPLH AA H+ ++E+L ++GA +N + D T L A+
Sbjct: 542 ELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN--ALDTLGQTALHRAA 599
Query: 337 ANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKY 396
GH+ + LL +G+DP++++ +G +A + E + + D+ R
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIR-TSDVDYRLLEAS 658
Query: 397 IKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYL 456
T++ S++ + D + H T + G N++ S L + G+ +
Sbjct: 659 KAGDLETVKQLCSSQNVNCRDLEGRHS-----TPLHFAAGYNRV---SVVEYLLHHGADV 710
Query: 457 ENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLL 516
+ +C YGH +V L + GA VN+++ TPL + +G + KLLL
Sbjct: 711 HAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
Query: 517 EAGADPQKTDKRKKTALHYANHSSLGLTD 545
+ GADP K ++ T L + D
Sbjct: 771 KHGADPTKKNRDGNTPLDLVKEGDTDIQD 799
>7301359 [M] KOG4177 Ankyrin
Length = 1181
Score = 95.5 bits (236), Expect = 3e-19
Identities = 81/284 (28%), Positives = 127/284 (44%), Gaps = 20/284 (7%)
Query: 255 RDAGGR--TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELL 312
RD GR T L A + + + L+E G +V D G PLH A GH + ELL
Sbjct: 514 RDLDGRHSTPLHFAAGFNRVPVVQFLLEH-GAEVYAADKGGLVPLHNACSYGHYEVTELL 572
Query: 313 VRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEES 372
V++GANVN+ D++ TPL +A+A G ++ K LL HGADP N G + + ++E
Sbjct: 573 VKHGANVNVS--DLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKES- 629
Query: 373 DMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDIS 432
D+D ++ +L A + + R + S++ D Q + T +
Sbjct: 630 --DHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCR----DAQGRNS-----TPLH 678
Query: 433 SKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
G N A L G+ + + + YGH D+ +L + VN +
Sbjct: 679 LAAGYNNFECAE---YLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNAT 735
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+K G TPL + +G + LLL GAD ++ +T + A
Sbjct: 736 DKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA 779
Score = 83.2 bits (204), Expect = 2e-15
Identities = 80/287 (27%), Positives = 131/287 (44%), Gaps = 26/287 (9%)
Query: 255 RDAGGR--TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELL 312
RD GR T L A G+ ++ + L+ G + D G PLH GH+ +V LL
Sbjct: 51 RDTAGRKSTPLHFAAGYGRREVVEFLLNS-GASIQACDEGGLHPLHNCCSFGHAEVVRLL 109
Query: 313 VRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEES 372
++ GA+ N + D + TPL +A++ G ++V LL HGA+ T+ N++ + +E +E +
Sbjct: 110 LKAGASPN--TTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEAT 167
Query: 373 DMDNDDRRIV--HDMKDMLKRATRKYIKHSHRTLQSS-SMSRHSDDIDKQLNHDDDFYWT 429
R ++ KD L A R + L + +++ H+ D +
Sbjct: 168 ------RPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASD----GRRSTPLHLA 217
Query: 430 DISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQV 489
+++G ++L A+ A + GG +C YGH DV L + GA V
Sbjct: 218 AGYNRIGIVEILLANGADVHA-----KDKGGLVPLH---NACSYGHFDVTKLLIQAGANV 269
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
N ++ TPL + + V V LLL GADP + K+A+ A
Sbjct: 270 NANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAA 316
Score = 81.3 bits (199), Expect = 7e-15
Identities = 93/309 (30%), Positives = 132/309 (42%), Gaps = 27/309 (8%)
Query: 254 HRDAGGR-TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELL 312
H G R T L +A + + + L+ +G DV+ +D G PLH A GH + +LL
Sbjct: 204 HASDGRRSTPLHLAAGYNRIGIVEILLA-NGADVHAKDKGGLVPLHNACSYGHFDVTKLL 262
Query: 313 VRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEES 372
++ GANVN D++ TPL +A++ + V LL GADPT++N SAI++
Sbjct: 263 IQAGANVNAN--DLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRE 320
Query: 373 DMDNDDRRIVHDMK-DMLKRATRKYIKHSHRTLQSSSMSR--HSDDIDKQLNHDDDFYWT 429
+ RI + K L A RK + L + + H D L+
Sbjct: 321 LRE----RIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLH-------L 369
Query: 430 DISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQV 489
+ S GK K L L GS L + + H D + + L GA+V
Sbjct: 370 AVVSPDGKRKQLME----LLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKV 425
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGL--TDPD 547
N + GQTPL V+LLL AD TA A+ S L L PD
Sbjct: 426 NALDSLGQTPLHRCA--RDEQAVRLLLSYAADTNIVSLEGLTAAQLASDSVLKLLKNPPD 483
Query: 548 -EVNLLKAA 555
E +LL+AA
Sbjct: 484 SETHLLEAA 492
Score = 76.3 bits (186), Expect = 2e-13
Identities = 75/282 (26%), Positives = 118/282 (41%), Gaps = 31/282 (10%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
AC G+ KKLI + D +TPLH AA G +VE L+ +GA +IQ+ D
Sbjct: 30 ACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGA--SIQACD 87
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDM 385
PL + + GH VV+ LL GA P + + + + +D + H
Sbjct: 88 EGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHG- 146
Query: 386 KDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASK 445
H+ R + + +D+ + + ++ + K++LL+A++
Sbjct: 147 -----------ANHTIRNSEQKTPLELADEATRPV----------LTGEYRKDELLEAAR 185
Query: 446 EGK----LAYVGSYLENGGRPDFRCFLE---SCIYGHDDVVSLFLAFGAQVNMSNKEGQT 498
G LA + N D R + Y +V + LA GA V+ +K G
Sbjct: 186 SGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLV 245
Query: 499 PLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSS 540
PL + GH +V KLL++AGA+ D T LH A S
Sbjct: 246 PLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKS 287
Score = 75.9 bits (185), Expect = 3e-13
Identities = 78/296 (26%), Positives = 130/296 (43%), Gaps = 31/296 (10%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L + GK +L+ G +N+++ A TPLH AA H +E+L++ GA VN
Sbjct: 369 LAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVN-- 426
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEE--SDMDNDDRR 380
+ D TPL + + V+ LL + AD +V+ +GL+A + + + N
Sbjct: 427 ALDSLGQTPLHRCARDEQ--AVRLLLSYAADTNIVSLEGLTAAQLASDSVLKLLKNPPDS 484
Query: 381 IVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKL 440
H +L+ A + R + ++ +S + D+D + + T + G N++
Sbjct: 485 ETH----LLEAAKAGDLDTVRRIVLNNPISVNCRDLDGR-------HSTPLHFAAGFNRV 533
Query: 441 LKAS---KEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQ 497
+ G Y + GG +C YGH +V L + GA VN+S+
Sbjct: 534 PVVQFLLEHGAEVYAA---DKGGLVPLH---NACSYGHYEVTELLVKHGANVNVSDLWKF 587
Query: 498 TPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTDPDEVNLLK 553
TPL + +G ++ KLLL+ GADP K ++ T S D D LL+
Sbjct: 588 TPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKES-----DHDVAELLR 638
>CE06705 [M] KOG4177 Ankyrin
Length = 1815
Score = 94.7 bits (234), Expect = 6e-19
Identities = 83/287 (28%), Positives = 129/287 (44%), Gaps = 22/287 (7%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
+A G L +A +G ++ ++LI+ V+ GNT LH A+L G S IV +LV N
Sbjct: 63 NANGLNSLHLASKEGHSEVVRELIKRQA-QVDAATRKGNTALHIASLAGQSLIVTILVEN 121
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
GANVN+QS + F TPL A+ H VVKYLL HGA+ + G + + ++
Sbjct: 122 GANVNVQSVNGF--TPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQ---- 175
Query: 376 NDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKL 435
DR + +++ K R L + ++ DD + + D++SK
Sbjct: 176 GHDRVVAVLLENDSKGKVR---------LPALHIAAKKDDTTAATLLLQNEHNPDVTSKS 226
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQV 489
G L A+ G LE G +++ + +G ++ +L L+ GA +
Sbjct: 227 GFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAII 286
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ K+ TPL + GH VV LL+ GA K LH A
Sbjct: 287 DSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMA 333
Score = 80.1 bits (196), Expect = 2e-14
Identities = 81/311 (26%), Positives = 131/311 (42%), Gaps = 39/311 (12%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A + D+ + LI +G V+ Q TPLH A+ G++ IV LL++ GAN
Sbjct: 458 GETPLHLAARANQTDVVRVLIR-NGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGAN 516
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIES----------- 367
N + D + +PL A+ G V LLDH AD T++ KG + +
Sbjct: 517 SNATTRDNY--SPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVR 574
Query: 368 --IEEESDMDNDDRRIV----------HDMKDMLK----RATRKYIKHSHRTLQSSSMSR 411
+E + +D + + V +D ML + + K+ + L ++
Sbjct: 575 LLLERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKN 634
Query: 412 HSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRC----- 466
+ L D + S+ G L +++EG G +ENG +
Sbjct: 635 QMEIASTLLQFKAD---PNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLT 691
Query: 467 FLESCIY-GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKT 525
+ C H V + GA++N G TPL ++ G +N+VK L+E GAD +
Sbjct: 692 AMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEK 751
Query: 526 DKRKKTALHYA 536
+ T LH A
Sbjct: 752 TRASYTPLHQA 762
Score = 69.7 bits (169), Expect = 2e-11
Identities = 76/294 (25%), Positives = 129/294 (43%), Gaps = 22/294 (7%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G ++ + L+E+ G +VN Q +PLH A G + + LL+ GA
Sbjct: 227 GFTPLHIAAHYGHENVGQLLLEK-GANVNYQARHNISPLHVATKWGRTNMANLLLSRGAI 285
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
++ ++ D+ TPL A+ +GH VV L+ GA + GL+ + + +D
Sbjct: 286 IDSRTKDLL--TPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAAR 343
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSS-------MSRHSDDIDKQLNHDDDFYWTDI 431
+ H + + T Y+ H + R +D + LN F I
Sbjct: 344 TLLYH--RAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALN---GFTPLHI 398
Query: 432 SSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNM 491
+ K + K+++ + + A + + E+G P + G ++V L GA ++
Sbjct: 399 ACKKNRIKVVELLLKYRAA-IEATTESGLTP----LHVAAFMGAINIVIYLLQQGANPDV 453
Query: 492 SNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTD 545
G+TPL L+ +VV++L+ GA + +T LH A S LG TD
Sbjct: 454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIA--SRLGNTD 505
Score = 64.3 bits (155), Expect = 9e-10
Identities = 37/103 (35%), Positives = 58/103 (55%), Gaps = 3/103 (2%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T + + + +A+ ++ +G ++N + NAG TPLH A G +V+ LV NGA+
Sbjct: 689 GLTAMHLCAQEDHVPVAQ-ILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGAD 747
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
V ++ + TPL A+ GH N V+YLL++GA P A G
Sbjct: 748 VGEKTRASY--TPLHQAAQQGHNNCVRYLLENGASPNEQTATG 788
Score = 61.2 bits (147), Expect = 7e-09
Identities = 66/266 (24%), Positives = 115/266 (42%), Gaps = 24/266 (9%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G ++ + L+E G V+ + TPLH AA + + LL+ NGA+
Sbjct: 557 GFTPLHLASKYGNLEVVRLLLER-GTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGAS 615
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + TPL A+ + + LL ADP + G + + +E +
Sbjct: 616 AKAAAKNGY--TPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISG 673
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDID-KQLNHDDDFYWTDISSKL-- 435
++ + D+ +A + L + + D + Q+ +++ +I+SK
Sbjct: 674 L-LIENGSDVGAKA--------NNGLTAMHLCAQEDHVPVAQILYNNG---AEINSKTNA 721
Query: 436 GKNKLLKASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQV 489
G L A G+L V +ENG R + ++ GH++ V L GA
Sbjct: 722 GYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASP 781
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLL 515
N GQTPL ++ G+V+VV+ L
Sbjct: 782 NEQTATGQTPLSIAQRLGYVSVVETL 807
>CE06704 [M] KOG4177 Ankyrin
Length = 1867
Score = 94.7 bits (234), Expect = 6e-19
Identities = 83/287 (28%), Positives = 129/287 (44%), Gaps = 22/287 (7%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
+A G L +A +G ++ ++LI+ V+ GNT LH A+L G S IV +LV N
Sbjct: 63 NANGLNSLHLASKEGHSEVVRELIKRQA-QVDAATRKGNTALHIASLAGQSLIVTILVEN 121
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
GANVN+QS + F TPL A+ H VVKYLL HGA+ + G + + ++
Sbjct: 122 GANVNVQSVNGF--TPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQ---- 175
Query: 376 NDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKL 435
DR + +++ K R L + ++ DD + + D++SK
Sbjct: 176 GHDRVVAVLLENDSKGKVR---------LPALHIAAKKDDTTAATLLLQNEHNPDVTSKS 226
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQV 489
G L A+ G LE G +++ + +G ++ +L L+ GA +
Sbjct: 227 GFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAII 286
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ K+ TPL + GH VV LL+ GA K LH A
Sbjct: 287 DSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMA 333
Score = 80.1 bits (196), Expect = 2e-14
Identities = 81/311 (26%), Positives = 131/311 (42%), Gaps = 39/311 (12%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A + D+ + LI +G V+ Q TPLH A+ G++ IV LL++ GAN
Sbjct: 458 GETPLHLAARANQTDVVRVLIR-NGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGAN 516
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIES----------- 367
N + D + +PL A+ G V LLDH AD T++ KG + +
Sbjct: 517 SNATTRDNY--SPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVR 574
Query: 368 --IEEESDMDNDDRRIV----------HDMKDMLK----RATRKYIKHSHRTLQSSSMSR 411
+E + +D + + V +D ML + + K+ + L ++
Sbjct: 575 LLLERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKN 634
Query: 412 HSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRC----- 466
+ L D + S+ G L +++EG G +ENG +
Sbjct: 635 QMEIASTLLQFKAD---PNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLT 691
Query: 467 FLESCIY-GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKT 525
+ C H V + GA++N G TPL ++ G +N+VK L+E GAD +
Sbjct: 692 AMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEK 751
Query: 526 DKRKKTALHYA 536
+ T LH A
Sbjct: 752 TRASYTPLHQA 762
Score = 69.7 bits (169), Expect = 2e-11
Identities = 76/294 (25%), Positives = 129/294 (43%), Gaps = 22/294 (7%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G ++ + L+E+ G +VN Q +PLH A G + + LL+ GA
Sbjct: 227 GFTPLHIAAHYGHENVGQLLLEK-GANVNYQARHNISPLHVATKWGRTNMANLLLSRGAI 285
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
++ ++ D+ TPL A+ +GH VV L+ GA + GL+ + + +D
Sbjct: 286 IDSRTKDLL--TPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAAR 343
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSS-------MSRHSDDIDKQLNHDDDFYWTDI 431
+ H + + T Y+ H + R +D + LN F I
Sbjct: 344 TLLYH--RAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALN---GFTPLHI 398
Query: 432 SSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNM 491
+ K + K+++ + + A + + E+G P + G ++V L GA ++
Sbjct: 399 ACKKNRIKVVELLLKYRAA-IEATTESGLTP----LHVAAFMGAINIVIYLLQQGANPDV 453
Query: 492 SNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTD 545
G+TPL L+ +VV++L+ GA + +T LH A S LG TD
Sbjct: 454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIA--SRLGNTD 505
Score = 64.3 bits (155), Expect = 9e-10
Identities = 37/103 (35%), Positives = 58/103 (55%), Gaps = 3/103 (2%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T + + + +A+ ++ +G ++N + NAG TPLH A G +V+ LV NGA+
Sbjct: 689 GLTAMHLCAQEDHVPVAQ-ILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGAD 747
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
V ++ + TPL A+ GH N V+YLL++GA P A G
Sbjct: 748 VGEKTRASY--TPLHQAAQQGHNNCVRYLLENGASPNEQTATG 788
Score = 61.2 bits (147), Expect = 7e-09
Identities = 66/266 (24%), Positives = 115/266 (42%), Gaps = 24/266 (9%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G ++ + L+E G V+ + TPLH AA + + LL+ NGA+
Sbjct: 557 GFTPLHLASKYGNLEVVRLLLER-GTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGAS 615
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + TPL A+ + + LL ADP + G + + +E +
Sbjct: 616 AKAAAKNGY--TPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISG 673
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDID-KQLNHDDDFYWTDISSKL-- 435
++ + D+ +A + L + + D + Q+ +++ +I+SK
Sbjct: 674 L-LIENGSDVGAKA--------NNGLTAMHLCAQEDHVPVAQILYNNG---AEINSKTNA 721
Query: 436 GKNKLLKASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQV 489
G L A G+L V +ENG R + ++ GH++ V L GA
Sbjct: 722 GYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASP 781
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLL 515
N GQTPL ++ G+V+VV+ L
Sbjct: 782 NEQTATGQTPLSIAQRLGYVSVVETL 807
>CE06703 [M] KOG4177 Ankyrin
Length = 1809
Score = 94.7 bits (234), Expect = 6e-19
Identities = 83/287 (28%), Positives = 129/287 (44%), Gaps = 22/287 (7%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
+A G L +A +G ++ ++LI+ V+ GNT LH A+L G S IV +LV N
Sbjct: 63 NANGLNSLHLASKEGHSEVVRELIKRQA-QVDAATRKGNTALHIASLAGQSLIVTILVEN 121
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
GANVN+QS + F TPL A+ H VVKYLL HGA+ + G + + ++
Sbjct: 122 GANVNVQSVNGF--TPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQ---- 175
Query: 376 NDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKL 435
DR + +++ K R L + ++ DD + + D++SK
Sbjct: 176 GHDRVVAVLLENDSKGKVR---------LPALHIAAKKDDTTAATLLLQNEHNPDVTSKS 226
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQV 489
G L A+ G LE G +++ + +G ++ +L L+ GA +
Sbjct: 227 GFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAII 286
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ K+ TPL + GH VV LL+ GA K LH A
Sbjct: 287 DSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMA 333
Score = 80.1 bits (196), Expect = 2e-14
Identities = 81/311 (26%), Positives = 131/311 (42%), Gaps = 39/311 (12%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A + D+ + LI +G V+ Q TPLH A+ G++ IV LL++ GAN
Sbjct: 458 GETPLHLAARANQTDVVRVLIR-NGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGAN 516
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIES----------- 367
N + D + +PL A+ G V LLDH AD T++ KG + +
Sbjct: 517 SNATTRDNY--SPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVR 574
Query: 368 --IEEESDMDNDDRRIV----------HDMKDMLK----RATRKYIKHSHRTLQSSSMSR 411
+E + +D + + V +D ML + + K+ + L ++
Sbjct: 575 LLLERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKN 634
Query: 412 HSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRC----- 466
+ L D + S+ G L +++EG G +ENG +
Sbjct: 635 QMEIASTLLQFKAD---PNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLT 691
Query: 467 FLESCIY-GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKT 525
+ C H V + GA++N G TPL ++ G +N+VK L+E GAD +
Sbjct: 692 AMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEK 751
Query: 526 DKRKKTALHYA 536
+ T LH A
Sbjct: 752 TRASYTPLHQA 762
Score = 69.7 bits (169), Expect = 2e-11
Identities = 76/294 (25%), Positives = 129/294 (43%), Gaps = 22/294 (7%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G ++ + L+E+ G +VN Q +PLH A G + + LL+ GA
Sbjct: 227 GFTPLHIAAHYGHENVGQLLLEK-GANVNYQARHNISPLHVATKWGRTNMANLLLSRGAI 285
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
++ ++ D+ TPL A+ +GH VV L+ GA + GL+ + + +D
Sbjct: 286 IDSRTKDLL--TPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAAR 343
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSS-------MSRHSDDIDKQLNHDDDFYWTDI 431
+ H + + T Y+ H + R +D + LN F I
Sbjct: 344 TLLYH--RAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALN---GFTPLHI 398
Query: 432 SSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNM 491
+ K + K+++ + + A + + E+G P + G ++V L GA ++
Sbjct: 399 ACKKNRIKVVELLLKYRAA-IEATTESGLTP----LHVAAFMGAINIVIYLLQQGANPDV 453
Query: 492 SNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTD 545
G+TPL L+ +VV++L+ GA + +T LH A S LG TD
Sbjct: 454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIA--SRLGNTD 505
Score = 64.3 bits (155), Expect = 9e-10
Identities = 37/103 (35%), Positives = 58/103 (55%), Gaps = 3/103 (2%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T + + + +A+ ++ +G ++N + NAG TPLH A G +V+ LV NGA+
Sbjct: 689 GLTAMHLCAQEDHVPVAQ-ILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGAD 747
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
V ++ + TPL A+ GH N V+YLL++GA P A G
Sbjct: 748 VGEKTRASY--TPLHQAAQQGHNNCVRYLLENGASPNEQTATG 788
Score = 61.2 bits (147), Expect = 7e-09
Identities = 66/266 (24%), Positives = 115/266 (42%), Gaps = 24/266 (9%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G ++ + L+E G V+ + TPLH AA + + LL+ NGA+
Sbjct: 557 GFTPLHLASKYGNLEVVRLLLER-GTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGAS 615
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + TPL A+ + + LL ADP + G + + +E +
Sbjct: 616 AKAAAKNGY--TPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISG 673
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDID-KQLNHDDDFYWTDISSKL-- 435
++ + D+ +A + L + + D + Q+ +++ +I+SK
Sbjct: 674 L-LIENGSDVGAKA--------NNGLTAMHLCAQEDHVPVAQILYNNG---AEINSKTNA 721
Query: 436 GKNKLLKASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQV 489
G L A G+L V +ENG R + ++ GH++ V L GA
Sbjct: 722 GYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASP 781
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLL 515
N GQTPL ++ G+V+VV+ L
Sbjct: 782 NEQTATGQTPLSIAQRLGYVSVVETL 807
>CE06702 [M] KOG4177 Ankyrin
Length = 2039
Score = 94.7 bits (234), Expect = 6e-19
Identities = 83/287 (28%), Positives = 129/287 (44%), Gaps = 22/287 (7%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
+A G L +A +G ++ ++LI+ V+ GNT LH A+L G S IV +LV N
Sbjct: 63 NANGLNSLHLASKEGHSEVVRELIKRQA-QVDAATRKGNTALHIASLAGQSLIVTILVEN 121
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
GANVN+QS + F TPL A+ H VVKYLL HGA+ + G + + ++
Sbjct: 122 GANVNVQSVNGF--TPLYMAAQENHEEVVKYLLKHGANQALSTEDGFTPLAVALQQ---- 175
Query: 376 NDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKL 435
DR + +++ K R L + ++ DD + + D++SK
Sbjct: 176 GHDRVVAVLLENDSKGKVR---------LPALHIAAKKDDTTAATLLLQNEHNPDVTSKS 226
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQV 489
G L A+ G LE G +++ + +G ++ +L L+ GA +
Sbjct: 227 GFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAII 286
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ K+ TPL + GH VV LL+ GA K LH A
Sbjct: 287 DSRTKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMA 333
Score = 80.1 bits (196), Expect = 2e-14
Identities = 81/311 (26%), Positives = 131/311 (42%), Gaps = 39/311 (12%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A + D+ + LI +G V+ Q TPLH A+ G++ IV LL++ GAN
Sbjct: 458 GETPLHLAARANQTDVVRVLIR-NGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGAN 516
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIES----------- 367
N + D + +PL A+ G V LLDH AD T++ KG + +
Sbjct: 517 SNATTRDNY--SPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHLASKYGNLEVVR 574
Query: 368 --IEEESDMDNDDRRIV----------HDMKDMLK----RATRKYIKHSHRTLQSSSMSR 411
+E + +D + + V +D ML + + K+ + L ++
Sbjct: 575 LLLERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGASAKAAAKNGYTPLHIAAKKN 634
Query: 412 HSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRC----- 466
+ L D + S+ G L +++EG G +ENG +
Sbjct: 635 QMEIASTLLQFKAD---PNAKSRAGFTPLHLSAQEGHKEISGLLIENGSDVGAKANNGLT 691
Query: 467 FLESCIY-GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKT 525
+ C H V + GA++N G TPL ++ G +N+VK L+E GAD +
Sbjct: 692 AMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGADVGEK 751
Query: 526 DKRKKTALHYA 536
+ T LH A
Sbjct: 752 TRASYTPLHQA 762
Score = 69.7 bits (169), Expect = 2e-11
Identities = 76/294 (25%), Positives = 129/294 (43%), Gaps = 22/294 (7%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G ++ + L+E+ G +VN Q +PLH A G + + LL+ GA
Sbjct: 227 GFTPLHIAAHYGHENVGQLLLEK-GANVNYQARHNISPLHVATKWGRTNMANLLLSRGAI 285
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
++ ++ D+ TPL A+ +GH VV L+ GA + GL+ + + +D
Sbjct: 286 IDSRTKDLL--TPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAAR 343
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSS-------MSRHSDDIDKQLNHDDDFYWTDI 431
+ H + + T Y+ H + R +D + LN F I
Sbjct: 344 TLLYH--RAPVDDVTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALN---GFTPLHI 398
Query: 432 SSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNM 491
+ K + K+++ + + A + + E+G P + G ++V L GA ++
Sbjct: 399 ACKKNRIKVVELLLKYRAA-IEATTESGLTP----LHVAAFMGAINIVIYLLQQGANPDV 453
Query: 492 SNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTD 545
G+TPL L+ +VV++L+ GA + +T LH A S LG TD
Sbjct: 454 ETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIA--SRLGNTD 505
Score = 64.3 bits (155), Expect = 9e-10
Identities = 37/103 (35%), Positives = 58/103 (55%), Gaps = 3/103 (2%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T + + + +A+ ++ +G ++N + NAG TPLH A G +V+ LV NGA+
Sbjct: 689 GLTAMHLCAQEDHVPVAQ-ILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVENGAD 747
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
V ++ + TPL A+ GH N V+YLL++GA P A G
Sbjct: 748 VGEKTRASY--TPLHQAAQQGHNNCVRYLLENGASPNEQTATG 788
Score = 61.2 bits (147), Expect = 7e-09
Identities = 66/266 (24%), Positives = 115/266 (42%), Gaps = 24/266 (9%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G ++ + L+E G V+ + TPLH AA + + LL+ NGA+
Sbjct: 557 GFTPLHLASKYGNLEVVRLLLER-GTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGAS 615
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + TPL A+ + + LL ADP + G + + +E +
Sbjct: 616 AKAAAKNGY--TPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISG 673
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDID-KQLNHDDDFYWTDISSKL-- 435
++ + D+ +A + L + + D + Q+ +++ +I+SK
Sbjct: 674 L-LIENGSDVGAKA--------NNGLTAMHLCAQEDHVPVAQILYNNG---AEINSKTNA 721
Query: 436 GKNKLLKASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQV 489
G L A G+L V +ENG R + ++ GH++ V L GA
Sbjct: 722 GYTPLHVACHFGQLNMVKFLVENGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASP 781
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLL 515
N GQTPL ++ G+V+VV+ L
Sbjct: 782 NEQTATGQTPLSIAQRLGYVSVVETL 807
>7301132 [R] KOG0504 FOG: Ankyrin repeat
Length = 784
Score = 94.7 bits (234), Expect = 6e-19
Identities = 78/275 (28%), Positives = 125/275 (45%), Gaps = 49/275 (17%)
Query: 265 IACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSY 324
+AC G Y+LA+ L+ V D+ +TPL EAA GH IV+LL+ + A+VN ++
Sbjct: 1 MACSAGYYELAQVLLAMSAAQVEDKGQKDSTPLMEAASAGHLDIVKLLLNHNADVN--AH 58
Query: 325 DMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHD 384
+TPL+ A A G ++VVK LL HGA ++EE+++
Sbjct: 59 CATGNTPLMFACAGGQVDVVKVLLKHGA--------------NVEEQNE----------- 93
Query: 385 MKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKAS 444
+ H L ++ + H + L H S++ ++ L A
Sbjct: 94 --------------NGHTPLMEAASAGHVEVAKVLLEHGAGI--NTHSNEFKESALTLAC 137
Query: 445 KEGKLAYVGSYLENGGRPDFR------CFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQT 498
+G L V L+ G + + +E+ + GH +V L L GAQVNM ++
Sbjct: 138 YKGHLDMVRFLLQAGADQEHKTDEMHTALMEASMDGHVEVARLLLDSGAQVNMPTDSFES 197
Query: 499 PLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTAL 533
PL L+ GHV + LL+E GA+ ++ + T L
Sbjct: 198 PLTLAACGGHVELATLLIERGANIEEVNDEGYTPL 232
Score = 84.3 bits (207), Expect = 8e-16
Identities = 78/293 (26%), Positives = 136/293 (45%), Gaps = 27/293 (9%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
H + + L +AC KG D+ + L++ G D + + +T L EA+++GH + LL+
Sbjct: 124 HSNEFKESALTLACYKGHLDMVRFLLQA-GADQEHKTDEMHTALMEASMDGHVEVARLLL 182
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESD 373
+GA VN+ + D F ++PL A+ GH+ + L++ GA+ VN +G + + E
Sbjct: 183 DSGAQVNMPT-DSF-ESPLTLAACGGHVELATLLIERGANIEEVNDEGYTPLMEAAREG- 239
Query: 374 MDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQ--SSSMSRHSDDIDKQLNHDDDFYWTDI 431
+++ + K AT + + + TL M + I + N
Sbjct: 240 --HEEMVALLLSKGANINATTEETQETALTLACCGGFMEVAAFLIKEGAN---------- 287
Query: 432 SSKLG-KNKLLKASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLA 484
+LG L++AS+EG V L+ + +C GH D + L+
Sbjct: 288 -LELGASTPLMEASQEGHTDLVSFLLKKKANVHAETQTGDTALTHACENGHTDAAGVLLS 346
Query: 485 FGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQK-TDKRKKTALHYA 536
+GA++ ++ G+TPLM + GH+ VK L++ GA+ K T TAL A
Sbjct: 347 YGAELEHESEGGRTPLMKACRAGHLCTVKFLIQKGANVNKQTTSNDHTALSLA 399
Score = 82.8 bits (203), Expect = 2e-15
Identities = 72/272 (26%), Positives = 123/272 (44%), Gaps = 51/272 (18%)
Query: 257 AGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNG 316
A G T L AC G+ D+ K L++ G +V +Q+ G+TPL EAA GH + ++L+ +G
Sbjct: 60 ATGNTPLMFACAGGQVDVVKVLLKH-GANVEEQNENGHTPLMEAASAGHVEVAKVLLEHG 118
Query: 317 ANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDN 376
A +N S + F ++ L A GH+++V++LL GAD E ++D
Sbjct: 119 AGINTHSNE-FKESALTLACYKGHLDMVRFLLQAGADQ--------------EHKTD--- 160
Query: 377 DDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSD------DIDKQLNHDDDFYWTD 430
H L +SM H + D Q+N D + +
Sbjct: 161 ----------------------EMHTALMEASMDGHVEVARLLLDSGAQVNMPTDSFESP 198
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVN 490
++ + A+ L G+ +E + +E+ GH+++V+L L+ GA +N
Sbjct: 199 LTLAACGGHVELAT---LLIERGANIEEVNDEGYTPLMEAAREGHEEMVALLLSKGANIN 255
Query: 491 MSNKEGQ-TPLMLSVGRGHVNVVKLLLEAGAD 521
+ +E Q T L L+ G + V L++ GA+
Sbjct: 256 ATTEETQETALTLACCGGFMEVAAFLIKEGAN 287
Score = 81.3 bits (199), Expect = 7e-15
Identities = 90/344 (26%), Positives = 145/344 (41%), Gaps = 63/344 (18%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L A G D+ K L+ + DVN GNTPL A G +V++L+++GANV
Sbjct: 31 TPLMEAASAGHLDIVKLLLNHNA-DVNAHCATGNTPLMFACAGGQVDVVKVLLKHGANVE 89
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRR 380
Q+ + TPL++A++ GH+ V K LL+HGA G++ + +ES + +
Sbjct: 90 EQNENGH--TPLMEAASAGHVEVAKVLLEHGA--------GINTHSNEFKESALTLACYK 139
Query: 381 IVHDMKDMLKRA---TRKYIKHSHRTLQSSSMSRHSD------DIDKQLNHDDDFYWTDI 431
DM L +A H L +SM H + D Q+N D + + +
Sbjct: 140 GHLDMVRFLLQAGADQEHKTDEMHTALMEASMDGHVEVARLLLDSGAQVNMPTDSFESPL 199
Query: 432 SSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNM 491
+ + A+ L G+ +E + +E+ GH+++V+L L+ GA +N
Sbjct: 200 TLAACGGHVELATL---LIERGANIEEVNDEGYTPLMEAAREGHEEMVALLLSKGANINA 256
Query: 492 SNKEGQ-------------------------------TPLMLSVGRGHVNVVKLLLEAGA 520
+ +E Q TPLM + GH ++V LL+ A
Sbjct: 257 TTEETQETALTLACCGGFMEVAAFLIKEGANLELGASTPLMEASQEGHTDLVSFLLKKKA 316
Query: 521 DPQKTDKRKKTALHYANHSSLGLTDPDEVNLLKAAVRAKYGYEV 564
+ + TAL +A + G TD A V YG E+
Sbjct: 317 NVHAETQTGDTALTHACEN--GHTD-------AAGVLLSYGAEL 351
Score = 70.9 bits (172), Expect = 9e-12
Identities = 71/262 (27%), Positives = 113/262 (43%), Gaps = 25/262 (9%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L +A G +LA LIE G ++ + ++ G TPL EAA GH +V LL+ GAN+N
Sbjct: 199 LTLAACGGHVELATLLIER-GANIEEVNDEGYTPLMEAAREGHEEMVALLLSKGANINAT 257
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIV 382
+ + +T L A G + V +L+ GA+ L A + E S + D
Sbjct: 258 TEET-QETALTLACCGGFMEVAAFLIKEGAN------LELGASTPLMEASQEGHTDL--- 307
Query: 383 HDMKDMLKRATRKY--IKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKL 440
+ +LK+ + + L + + H+D L++ + + S+ G+ L
Sbjct: 308 --VSFLLKKKANVHAETQTGDTALTHACENGHTDAAGVLLSYGAEL---EHESEGGRTPL 362
Query: 441 LKASKEGKLAYVGSYLENGGR-------PDFRCFLESCIYGHDDVVSLFLAFGAQVNMSN 493
+KA + G L V ++ G D +C GH VV L L A
Sbjct: 363 MKACRAGHLCTVKFLIQKGANVNKQTTSNDHTALSLACAGGHQSVVELLLKNNADPFHKL 422
Query: 494 KEGQTPLMLSVGRGHVNVVKLL 515
K+ T L+ + GH VV+LL
Sbjct: 423 KDNSTMLIEASKGGHTRVVELL 444
Score = 54.3 bits (129), Expect = 9e-07
Identities = 38/95 (40%), Positives = 51/95 (53%), Gaps = 4/95 (4%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGN-TPLHEAALNGHSAIVELL 312
H GGRT L AC G K LI++ G +VN Q + + T L A GH ++VELL
Sbjct: 353 HESEGGRTPLMKACRAGHLCTVKFLIQK-GANVNKQTTSNDHTALSLACAGGHQSVVELL 411
Query: 313 VRNGANVNIQSYDMFLDTPLIDASANGHINVVKYL 347
++N A+ + D T LI+AS GH VV+ L
Sbjct: 412 LKNNADPFHKLKDN--STMLIEASKGGHTRVVELL 444
>Hs4502093 [M] KOG4177 Ankyrin
Length = 1088
Score = 93.2 bits (230), Expect = 2e-18
Identities = 79/286 (27%), Positives = 128/286 (44%), Gaps = 18/286 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G+ ++ + L++ DG V + TPLH +A G + IV+ L++ GA+
Sbjct: 87 GETALHMAARSGQAEVVRYLVQ-DGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGAS 145
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N + + TPL ++ GH +V +LLDHGA ++ KG + + + ++
Sbjct: 146 PNAATTSGY--TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE--- 200
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ ++L + + L ++ H D+ L D ++K G
Sbjct: 201 ------VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 254
Query: 439 KLLKASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
L A+K+ ++ + LE G R + GH D+VSL L A VN+S
Sbjct: 255 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLS 314
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
NK G TPL L+ VNV ++L+ GA K T LH H
Sbjct: 315 NKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCH 360
Score = 80.9 bits (198), Expect = 9e-15
Identities = 74/313 (23%), Positives = 131/313 (41%), Gaps = 45/313 (14%)
Query: 260 RTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANV 319
+T L I+ GK D+ ++L+++ G N +G TPLH +A GH + L+ +GA++
Sbjct: 121 QTPLHISARLGKADIVQQLLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 179
Query: 320 NIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDR 379
+I + F TPL A+ G + V LL A P +A G S + + + DN
Sbjct: 180 SITTKKGF--TPLHVAAKYGKLEVANLLLQKSASP---DAAGKSGLTPLHVAAHYDNQKV 234
Query: 380 RI---------------------VHDMKDMLKRAT---------RKYIKHSHRTLQSSSM 409
+ + K+ + AT + ++ ++
Sbjct: 235 ALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQ 294
Query: 410 SRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE 469
H D + L + + ++S+K G L A++E ++ + G D + +
Sbjct: 295 EGHVDMVSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 351
Query: 470 ------SCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQ 523
C YG+ +V+ L A+VN K G TPL + +GH +++ +LL+ A P
Sbjct: 352 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 411
Query: 524 KTDKRKKTALHYA 536
+ TAL A
Sbjct: 412 ELTVNGNTALGIA 424
Score = 78.6 bits (192), Expect = 4e-14
Identities = 76/284 (26%), Positives = 121/284 (41%), Gaps = 18/284 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IAC K + + + L++ G + +G TP+H AA GH IV L+ +GA+
Sbjct: 21 GFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 79
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N + ++ +T L A+ +G VV+YL+ GA V AK + + + D
Sbjct: 80 PN--TTNVRGETALHMAARSGQAEVVRYLVQDGA---QVEAKAKDDQTPLHISARLGKAD 134
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
IV + + + L S+ H D L+H I++K G
Sbjct: 135 --IVQQLLQQ-GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL---SITTKKGFT 188
Query: 439 KLLKASKEGKLAYVGSYLENGGRPD------FRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
L A+K GKL L+ PD + Y + V L L GA + +
Sbjct: 189 PLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAA 248
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
K G TPL ++ + +++ LLE GAD ++ ++H A
Sbjct: 249 AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLA 292
Score = 57.0 bits (136), Expect = 1e-07
Identities = 55/263 (20%), Positives = 110/263 (40%), Gaps = 18/263 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A GK ++A L+++ + +G TPLH AA + + LL+ GA+
Sbjct: 186 GFTPLHVAAKYGKLEVANLLLQKSA-SPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS 244
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + + TPL A+ +++ LL++GAD V +G++++ +E +D
Sbjct: 245 PHAAAKNGY--TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD--- 299
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
M +L + L ++ D ++ + D +K+G
Sbjct: 300 ------MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYT 353
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGAQVNMS 492
L G + V L++ + + + ++ GH ++++ L A N
Sbjct: 354 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 413
Query: 493 NKEGQTPLMLSVGRGHVNVVKLL 515
G T L ++ G+++VV L
Sbjct: 414 TVNGNTALGIARRLGYISVVDTL 436
Score = 50.8 bits (120), Expect = 1e-05
Identities = 26/70 (37%), Positives = 37/70 (52%)
Query: 470 SCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRK 529
+C V+ L L GA + + G TP+ ++ GHVN+V L+ GA P T+ R
Sbjct: 28 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 87
Query: 530 KTALHYANHS 539
+TALH A S
Sbjct: 88 ETALHMAARS 97
>CE23926 [T] KOG4369 RTK signaling protein MASK/UNC-44
Length = 2584
Score = 92.4 bits (228), Expect = 3e-18
Identities = 96/325 (29%), Positives = 139/325 (42%), Gaps = 60/325 (18%)
Query: 225 KSSSIENSSNHKKQKHSAGKKIPKTK-RGVHRDAGGRTKLQ----IACDKGKYDLAKKLI 279
KS + ++ HS G + K R D T L+ IAC G D+ + L+
Sbjct: 1182 KSVQSQQQQGQLRRTHSEGDGAERAKSRSNAIDKATETTLETPLTIACANGHKDIVELLL 1241
Query: 280 EEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANG 339
+E G ++ +D G +PL AA GHS++VE+L++N A + QS D DT L A + G
Sbjct: 1242 KE-GANIEHRDKKGFSPLIIAATAGHSSVVEVLLKNHAAIEAQS-DRTKDTALSLACSGG 1299
Query: 340 HINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKH 399
+VV+ LL HGA N + R V D + ++ YI+
Sbjct: 1300 RKDVVELLLAHGA-----------------------NKEHRNVSDYTPLSLASSGGYIEI 1336
Query: 400 SHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENG 459
+ L + S ++N + SKLG + L+ AS G LE G
Sbjct: 1337 VNMLLTAGS----------EIN-------SRTGSKLGISPLMLASMNGHREATRVLLEKG 1379
Query: 460 GRPDFRCFLE---------SCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVN 510
D +E + G +VV L LA+ A V K G TPLM G+V+
Sbjct: 1380 S--DINAQIETNRNTALTLASFQGRTEVVKLLLAYNANVEHRAKTGLTPLMECASGGYVD 1437
Query: 511 VVKLLLEAGADPQKT--DKRKKTAL 533
V LL+ AGAD + + K TAL
Sbjct: 1438 VGNLLIAAGADTNASPVQQTKDTAL 1462
Score = 53.1 bits (126), Expect = 2e-06
Identities = 69/292 (23%), Positives = 118/292 (39%), Gaps = 26/292 (8%)
Query: 263 LQIACDKGKYDLAKKLIEEDG-YDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNI 321
L A +G D+ K ++ D+ + +PL A+ G+ +VE+L+ GA I
Sbjct: 393 LMEAAMEGHIDVCKLMLSRGTPADLCTEVTIEPSPLIVASAGGYPEVVEVLLAAGA--KI 450
Query: 322 QSYDMFLDTPLIDASA---NGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ +TPL++A A VVK LL A+ + N S+ +
Sbjct: 451 EELSNKKNTPLMEACAGDQGDQAGVVKLLLSKHAEVDVSNPDTGDTPLSLAARNGYIAIM 510
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ ++ D+ T ++ ++ + H + I L H +S
Sbjct: 511 KMLIEKGGDLTAGKTSPIVE--------AARNGHLECIQFILAHCKTIPQDQLS-----R 557
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFR-----CFLESCIYGHDDVVSLFLAFGAQVNM-S 492
L+ A+ G L V + G +F +++ H +VV L L+ GA VN S
Sbjct: 558 ALVSAADFGSLLIVEEVIRAGADLNFEQDERTALMKAAKGDHFEVVQLLLSKGASVNFKS 617
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQ-KTDKRKKTALHYANHSSLGL 543
+K T L L+ G++ + + L+ GADP K D + A H S+ L
Sbjct: 618 SKNDATALSLACSEGNMEIAEFLIRNGADPMLKMDDGVNCFMEVARHGSIDL 669
Score = 52.8 bits (125), Expect = 3e-06
Identities = 52/216 (24%), Positives = 92/216 (42%), Gaps = 28/216 (12%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +A +G+ ++ K L+ + +V + G TPL E A G+ + LL+ GA+ N
Sbjct: 1392 TALTLASFQGRTEVVKLLLAYNA-NVEHRAKTGLTPLMECASGGYVDVGNLLIAAGADTN 1450
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI-------------ES 367
DT L ++ GH V+ LL+ A + N KG +A+
Sbjct: 1451 ASPVQQTKDTALTISAEKGHEKFVRMLLNGDAAVDVRNKKGCTALWLACNGGYLSTAQAL 1510
Query: 368 IEEESDMDNDDRRIVHDMKDMLKRATRKYIKH---------SHRTLQSSSMSRHSDDIDK 418
+E+ +D D D R + M ++ + +K+ + + L + + +DDI K
Sbjct: 1511 LEKGADPDMFDNRKISPMMAAFRKGHVEIVKYMVNSAKQFPNEQDLIRAQQTAETDDIKK 1570
Query: 419 QLNHDDDFYWT-----DISSKLGKNKLLKASKEGKL 449
+ D + S++L KLL+ E K+
Sbjct: 1571 KCGECIDIIRSAKKAQAESAELAAQKLLELIDEEKV 1606
>CE06305 [T] KOG4369 RTK signaling protein MASK/UNC-44
Length = 2606
Score = 92.4 bits (228), Expect = 3e-18
Identities = 96/325 (29%), Positives = 139/325 (42%), Gaps = 60/325 (18%)
Query: 225 KSSSIENSSNHKKQKHSAGKKIPKTK-RGVHRDAGGRTKLQ----IACDKGKYDLAKKLI 279
KS + ++ HS G + K R D T L+ IAC G D+ + L+
Sbjct: 1182 KSVQSQQQQGQLRRTHSEGDGAERAKSRSNAIDKATETTLETPLTIACANGHKDIVELLL 1241
Query: 280 EEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANG 339
+E G ++ +D G +PL AA GHS++VE+L++N A + QS D DT L A + G
Sbjct: 1242 KE-GANIEHRDKKGFSPLIIAATAGHSSVVEVLLKNHAAIEAQS-DRTKDTALSLACSGG 1299
Query: 340 HINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKH 399
+VV+ LL HGA N + R V D + ++ YI+
Sbjct: 1300 RKDVVELLLAHGA-----------------------NKEHRNVSDYTPLSLASSGGYIEI 1336
Query: 400 SHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENG 459
+ L + S ++N + SKLG + L+ AS G LE G
Sbjct: 1337 VNMLLTAGS----------EIN-------SRTGSKLGISPLMLASMNGHREATRVLLEKG 1379
Query: 460 GRPDFRCFLE---------SCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVN 510
D +E + G +VV L LA+ A V K G TPLM G+V+
Sbjct: 1380 S--DINAQIETNRNTALTLASFQGRTEVVKLLLAYNANVEHRAKTGLTPLMECASGGYVD 1437
Query: 511 VVKLLLEAGADPQKT--DKRKKTAL 533
V LL+ AGAD + + K TAL
Sbjct: 1438 VGNLLIAAGADTNASPVQQTKDTAL 1462
Score = 53.1 bits (126), Expect = 2e-06
Identities = 69/292 (23%), Positives = 118/292 (39%), Gaps = 26/292 (8%)
Query: 263 LQIACDKGKYDLAKKLIEEDG-YDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNI 321
L A +G D+ K ++ D+ + +PL A+ G+ +VE+L+ GA I
Sbjct: 393 LMEAAMEGHIDVCKLMLSRGTPADLCTEVTIEPSPLIVASAGGYPEVVEVLLAAGA--KI 450
Query: 322 QSYDMFLDTPLIDASA---NGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ +TPL++A A VVK LL A+ + N S+ +
Sbjct: 451 EELSNKKNTPLMEACAGDQGDQAGVVKLLLSKHAEVDVSNPDTGDTPLSLAARNGYIAIM 510
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ ++ D+ T ++ ++ + H + I L H +S
Sbjct: 511 KMLIEKGGDLTAGKTSPIVE--------AARNGHLECIQFILAHCKTIPQDQLS-----R 557
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFR-----CFLESCIYGHDDVVSLFLAFGAQVNM-S 492
L+ A+ G L V + G +F +++ H +VV L L+ GA VN S
Sbjct: 558 ALVSAADFGSLLIVEEVIRAGADLNFEQDERTALMKAAKGDHFEVVQLLLSKGASVNFKS 617
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQ-KTDKRKKTALHYANHSSLGL 543
+K T L L+ G++ + + L+ GADP K D + A H S+ L
Sbjct: 618 SKNDATALSLACSEGNMEIAEFLIRNGADPMLKMDDGVNCFMEVARHGSIDL 669
Score = 52.8 bits (125), Expect = 3e-06
Identities = 52/216 (24%), Positives = 92/216 (42%), Gaps = 28/216 (12%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +A +G+ ++ K L+ + +V + G TPL E A G+ + LL+ GA+ N
Sbjct: 1392 TALTLASFQGRTEVVKLLLAYNA-NVEHRAKTGLTPLMECASGGYVDVGNLLIAAGADTN 1450
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI-------------ES 367
DT L ++ GH V+ LL+ A + N KG +A+
Sbjct: 1451 ASPVQQTKDTALTISAEKGHEKFVRMLLNGDAAVDVRNKKGCTALWLACNGGYLSTAQAL 1510
Query: 368 IEEESDMDNDDRRIVHDMKDMLKRATRKYIKH---------SHRTLQSSSMSRHSDDIDK 418
+E+ +D D D R + M ++ + +K+ + + L + + +DDI K
Sbjct: 1511 LEKGADPDMFDNRKISPMMAAFRKGHVEIVKYMVNSAKQFPNEQDLIRAQQTAETDDIKK 1570
Query: 419 QLNHDDDFYWT-----DISSKLGKNKLLKASKEGKL 449
+ D + S++L KLL+ E K+
Sbjct: 1571 KCGECIDIIRSAKKAQAESAELAAQKLLELIDEEKV 1606
>7295202 [M] KOG4177 Ankyrin
Length = 2443
Score = 91.3 bits (225), Expect = 7e-18
Identities = 78/289 (26%), Positives = 128/289 (43%), Gaps = 26/289 (8%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
+A G L +A G + +L+ G V+ GNT LH A+L G +V+LL+ +
Sbjct: 41 NANGLNALHLASKDGHIHVVSELLRR-GAIVDSATKKGNTALHIASLAGQEEVVKLLLEH 99
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
A+VN+QS + F TPL A+ H VV+ LL +GA+ ++ G + + ++
Sbjct: 100 NASVNVQSQNGF--TPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQG--- 154
Query: 376 NDDRRIVHD--MKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISS 433
HD + +L+ TR ++ L + ++ DD+ D+ + D++S
Sbjct: 155 -------HDKVVAVLLESDTRGKVR-----LPALHIAAKKDDVKAATLLLDNDHNPDVTS 202
Query: 434 KLGKNKLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLAFGA 487
K G L AS G ++ G ++ + +G ++VSL L G
Sbjct: 203 KSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGG 262
Query: 488 QVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ ++G TPL + GH VV +LLE GA K LH A
Sbjct: 263 NIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMA 311
Score = 81.6 bits (200), Expect = 5e-15
Identities = 77/279 (27%), Positives = 127/279 (44%), Gaps = 26/279 (9%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +A G +AK L++ + D N + G TPLH A +VELL+R+GA+++
Sbjct: 339 TALHVAAHCGHVRVAKLLLDRNA-DANARALNGFTPLHIACKKNRLKVVELLLRHGASIS 397
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRR 380
+ TPL A+ G +N+V YLL H A P + +G + + + ++ + R
Sbjct: 398 ATTESGL--TPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLH-LAARANQTDIIRI 454
Query: 381 IVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKL 440
++ + + RA + L +S + D + L H D ++K L
Sbjct: 455 LLRNGAQVDARA-----REQQTPLHIASRLGNVDIVMLLLQHGAQ---VDATTKDMYTAL 506
Query: 441 LKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGH-DDVVSLFLAFGAQVNMSNKEGQTP 499
A+KE G+ + + + I H D V ++ + GA ++ + K+G TP
Sbjct: 507 HIAAKE-------------GQDEVKDLIAKKITDHIDTVAAVLIENGAALDAATKKGFTP 553
Query: 500 LMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
L L+ GH+ V +LLL+ AD K T LH A H
Sbjct: 554 LHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACH 592
Score = 81.3 bits (199), Expect = 7e-15
Identities = 88/315 (27%), Positives = 139/315 (43%), Gaps = 47/315 (14%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G ++A LI++ G DVN +PLH AA G + +V LL+ G N
Sbjct: 205 GFTPLHIASHYGNQNIANLLIQK-GADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGN 263
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ ++ D TPL A+ +GH VV LL+ GA + GL+ + + + D
Sbjct: 264 IEAKTRDGL--TPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHV--DA 319
Query: 379 RRIVHDMKDMLKRATRKYIKH-------SHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDI 431
RI+ + + T Y+ H + + R++D + LN +T +
Sbjct: 320 ARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNG-----FTPL 374
Query: 432 SSKLGKNKL------------LKASKEGKL------AYVGS------YLENGGRPDFRCF 467
KN+L + A+ E L A++G L++ PD
Sbjct: 375 HIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTV 434
Query: 468 L-ESCIY-----GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
E+ ++ D++ + L GAQV+ +E QTPL ++ G+V++V LLL+ GA
Sbjct: 435 RGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQ 494
Query: 522 PQKTDKRKKTALHYA 536
T K TALH A
Sbjct: 495 VDATTKDMYTALHIA 509
Score = 72.4 bits (176), Expect = 3e-12
Identities = 72/279 (25%), Positives = 122/279 (42%), Gaps = 24/279 (8%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G ++ L++ D + G TPLH AA + I+ +L+RNGA
Sbjct: 403 GLTPLHVAAFMGCMNIVIYLLQHDA-SPDVPTVRGETPLHLAARANQTDIIRILLRNGAQ 461
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
V+ ++ + TPL AS G++++V LL HGA +A+ +E
Sbjct: 462 VDARAREQ--QTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQ----- 514
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
++KD++ + +I L + + D K+ F +++K G
Sbjct: 515 ----DEVKDLIAKKITDHIDTVAAVLIENGAAL--DAATKK-----GFTPLHLTAKYGHI 563
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQT 498
K+ + + K A V + +NG P +C Y + V L L GA + + K G T
Sbjct: 564 KVAQLLLQ-KEADVDAQGKNGVTP----LHVACHYNNQQVALLLLEKGASPHATAKNGHT 618
Query: 499 PLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYAN 537
PL ++ + +++ LLE GA K T LH ++
Sbjct: 619 PLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSS 657
Score = 68.6 bits (166), Expect = 5e-11
Identities = 71/302 (23%), Positives = 129/302 (42%), Gaps = 25/302 (8%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L + G +A+ L++++ DV+ Q G TPLH A + + LL+ GA+
Sbjct: 550 GFTPLHLTAKYGHIKVAQLLLQKEA-DVDAQGKNGVTPLHVACHYNNQQVALLLLEKGAS 608
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + TPL A+ +++ LL++GA + G + + +E + +
Sbjct: 609 PHATAKNGH--TPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISN 666
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
I H K A K+ L + D+++ + + D+++K G
Sbjct: 667 LLIEH------KAAVNHPAKNG---LTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYT 717
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRCFL------ESCIYGHDDVVSLFLAFGAQVNMS 492
L AS G+ V L+NG D + ++ GH +V+L L A N
Sbjct: 718 PLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQ 777
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLL------EAGADPQKTDKRKKTALHYANHSSLGLTDP 546
GQTPL ++ G+++V+ L E A P + +++ + A H S ++D
Sbjct: 778 TVNGQTPLHIARKLGYISVLDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESF-MSDS 836
Query: 547 DE 548
+E
Sbjct: 837 EE 838
Score = 63.9 bits (154), Expect = 1e-09
Identities = 81/313 (25%), Positives = 122/313 (38%), Gaps = 44/313 (14%)
Query: 250 KRGVHRDAGGR---TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
+ G DA R T L IA G D+ L++ G V+ T LH AA G
Sbjct: 457 RNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQH-GAQVDATTKDMYTALHIAAKEGQD 515
Query: 307 AIVEL---------------LVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHG 351
+ +L L+ NGA ++ + F TPL + GHI V + LL
Sbjct: 516 EVKDLIAKKITDHIDTVAAVLIENGAALDAATKKGF--TPLHLTAKYGHIKVAQLLLQKE 573
Query: 352 ADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSR 411
AD V+A+G + + + +N ++ K AT K + H L ++
Sbjct: 574 AD---VDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAK---NGHTPLHIAARKN 627
Query: 412 HSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKL----------AYVGSYLENGGR 461
D L + + SK G L +S+EG A V +NG
Sbjct: 628 QMDIATTLLEYGA---LANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLT 684
Query: 462 PDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
P C E + +V + GA ++M+ K G TPL ++ G N+V+ LL+ GA+
Sbjct: 685 PMHLCAQEDNV----NVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGAN 740
Query: 522 PQKTDKRKKTALH 534
T LH
Sbjct: 741 VDAATSIGYTPLH 753
Score = 55.8 bits (133), Expect = 3e-07
Identities = 32/108 (29%), Positives = 58/108 (53%), Gaps = 3/108 (2%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
H G T + + + ++A+ ++E++G +++ AG TPLH A+ G + +V L+
Sbjct: 677 HPAKNGLTPMHLCAQEDNVNVAE-ILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLL 735
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
+NGANV+ + + TPL + GH ++V LL+H A+ G
Sbjct: 736 QNGANVDAATSIGY--TPLHQTAQQGHCHIVNLLLEHKANANAQTVNG 781
>Hs4557349_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 162
Score = 90.1 bits (222), Expect = 1e-17
Identities = 56/132 (42%), Positives = 79/132 (59%), Gaps = 5/132 (3%)
Query: 241 SAGKKIPKTKRGVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEA 300
SA K +P V R+ G T L IA KG + L++ +G D N +D+AG TPLHEA
Sbjct: 3 SAMKLLPNM--AVKRNHRGETLLHIASIKGDIPSVEYLLQ-NGSDPNVKDHAGWTPLHEA 59
Query: 301 ALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAK 360
+GH +VELL+++ A VN Y D+PL DA+ NGH+++VK LL +GA VN
Sbjct: 60 CNHGHLKVVELLLQHKALVNTTGYQN--DSPLHDAAKNGHVDIVKLLLSYGASRNAVNIF 117
Query: 361 GLSAIESIEEES 372
GL ++ ++ES
Sbjct: 118 GLRPVDYTDDES 129
>Hs13386462 [R] KOG0504 FOG: Ankyrin repeat
Length = 435
Score = 89.7 bits (221), Expect = 2e-17
Identities = 97/339 (28%), Positives = 143/339 (41%), Gaps = 58/339 (17%)
Query: 258 GGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGA 317
G T L A G D+ K L+ D DVN Q GNT L A G IV++L+ GA
Sbjct: 79 GDITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 137
Query: 318 NVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDND 377
NI+ ++ TPL++A++ GH+ V + LLDHGA G++ + +ES +
Sbjct: 138 --NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA--------GINTHSNEFKESALTLA 187
Query: 378 DRRIVHDMKDMLKRA---TRKYIKHSHRTLQSSSMSRHSD------DIDKQLNHDDDFYW 428
+ DM L A H L + M H + D Q+N D +
Sbjct: 188 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 247
Query: 429 TDIS-SKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGA 487
+ ++ + G + L A L G+ LE + +E+ GH+++V+L LA GA
Sbjct: 248 SPLTLAACGGHVELAA----LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 303
Query: 488 QVNMSNKEGQ-------------------------------TPLMLSVGRGHVNVVKLLL 516
+N +E Q TPLM + GH+ +VK LL
Sbjct: 304 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 363
Query: 517 EAGADPQKTDKRKKTALHYANHSSLGLTDPDEVNLLKAA 555
+GA+ T TAL YA + G TD +V L A
Sbjct: 364 ASGANVHATTATGDTALTYACEN--GHTDVADVLLQAGA 400
Score = 86.7 bits (213), Expect = 2e-16
Identities = 80/282 (28%), Positives = 129/282 (45%), Gaps = 51/282 (18%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGN-TPLHEAALNGHSAIVELLVRNGA 317
G + L +AC G Y+LA+ L+ +V D+ N G+ TPL A+ G+ IV+LL+ + A
Sbjct: 46 GESLLCLACSAGYYELAQVLLAMHA-NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 104
Query: 318 NVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDND 377
+VN QS +T L A A G +++VK LL+ GA +IE+ ++
Sbjct: 105 DVNSQSATG--NTALTYACAGGFVDIVKVLLNEGA--------------NIEDHNE---- 144
Query: 378 DRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGK 437
+ H L ++ + H + L+H S++ +
Sbjct: 145 ---------------------NGHTPLMEAASAGHVEVARVLLDHGAGI--NTHSNEFKE 181
Query: 438 NKLLKASKEGKLAYVGSYLENGGRPDFR------CFLESCIYGHDDVVSLFLAFGAQVNM 491
+ L A +G L V LE G + + +E+C+ GH +V L L GAQVNM
Sbjct: 182 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 241
Query: 492 SNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTAL 533
++PL L+ GHV + LL+E GA+ ++ + T L
Sbjct: 242 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 283
Score = 75.1 bits (183), Expect = 5e-13
Identities = 70/280 (25%), Positives = 121/280 (43%), Gaps = 49/280 (17%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
H + + L +AC KG D+ + L+E G D + + +T L EA ++GH + LL+
Sbjct: 175 HSNEFKESALTLACYKGHLDMVRFLLEA-GADQEHKTDEMHTALMEACMDGHVEVARLLL 233
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESD 373
+GA VN+ + D F ++PL A+ GH+ + L++ GA+ VN +G + + E
Sbjct: 234 DSGAQVNMPA-DSF-ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREG- 290
Query: 374 MDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISS 433
H+ L A Q ++++ +++
Sbjct: 291 ---------HEEMVALLLA------------QGANINAQTEET----------------- 312
Query: 434 KLGKNKLLKASKEGKLAYVGSYLENGGRP-DFRC---FLESCIYGHDDVVSLFLAFGAQV 489
+ L + G + V +L G + C +E+ GH ++V LA GA V
Sbjct: 313 ---QETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANV 369
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRK 529
+ + G T L + GH +V +LL+AGAD K + K
Sbjct: 370 HATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 409
>7304338 [M] KOG4177 Ankyrin
Length = 1526
Score = 87.8 bits (216), Expect = 7e-17
Identities = 74/282 (26%), Positives = 133/282 (46%), Gaps = 19/282 (6%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L IA +G+ ++ + L+E +G + N G TPLH A G +V++L++NGA+++ Q
Sbjct: 511 LHIAAKEGQENIVQVLLE-NGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDFQ 569
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIV 382
+ TPL A+ + ++V+ LL +G+ P + G AI +++ ++ + +
Sbjct: 570 GKNDV--TPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQ 627
Query: 383 HDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLK 442
H + K L ++ + D + L ++ ++K G L
Sbjct: 628 HGADVNI------ISKSGFSPLHLAAQGGNVDMVQLLL----EYGVISAAAKNGLTPLHV 677
Query: 443 ASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEG 496
A++EG + LE+G R + + YGH D+V F+ A + MS+ G
Sbjct: 678 AAQEGHVLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIG 737
Query: 497 QTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
TPL + +GH+ ++ LLL A+P K TALH A++
Sbjct: 738 YTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASN 779
Score = 87.4 bits (215), Expect = 9e-17
Identities = 78/292 (26%), Positives = 132/292 (44%), Gaps = 32/292 (10%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
+A G L +A G D+ +L+ G +++ GNT LH A+L G ++ L+
Sbjct: 47 NANGLNALHLAAKDGYVDICCELLRR-GIKIDNATKKGNTALHIASLAGQHDVINQLILY 105
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
ANVN+QS + F TPL A+ H N + LL +GA+P++ G + + ++
Sbjct: 106 NANVNVQSLNGF--TPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQG--- 160
Query: 376 NDDRRIVHD--MKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQ---LNHDDDFYWTD 430
HD + +L+ R ++ L + ++ +D++ L HD + D
Sbjct: 161 -------HDKIVAVLLENDVRGKVR-----LPALHIAAKKNDVNAAKLLLQHDPN---AD 205
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRC------FLESCIYGHDDVVSLFLA 484
I SK G L A+ G + L N ++ +C +G + +L L
Sbjct: 206 IVSKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLC 265
Query: 485 FGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
GA+++ + ++G TPL + GHV V+K LL+ A K +ALH A
Sbjct: 266 RGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMA 317
Score = 84.0 bits (206), Expect = 1e-15
Identities = 81/285 (28%), Positives = 127/285 (44%), Gaps = 25/285 (8%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNA--GNTPLHEAALNGHSAIVELLVRNGAN 318
T L +A G +AK L++ Y N A G TPLH A +VELL+++GAN
Sbjct: 345 TALHVAAHCGHVKVAKLLLD---YKANPNARALNGFTPLHIACKKNRIKMVELLIKHGAN 401
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + TPL AS G IN+V YLL H A + +G + + + D
Sbjct: 402 IGATTESGL--TPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLHLAARANQADI-- 457
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRT-LQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGK 437
++ +L+ A I +T L +S + + I L H + + S
Sbjct: 458 ------IRILLRSAKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEI---NAQSNDKY 508
Query: 438 NKLLKASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQVNM 491
+ L A+KEG+ V LENG + F +C YG +VV + L GA ++
Sbjct: 509 SALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASIDF 568
Query: 492 SNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
K TPL ++ + ++V+LLL+ G+ P + + A+H A
Sbjct: 569 QGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIA 613
Score = 65.5 bits (158), Expect = 4e-10
Identities = 61/269 (22%), Positives = 117/269 (42%), Gaps = 31/269 (11%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +AC GK ++ + L++ +G ++ Q TPLH A + +IVELL++NG++
Sbjct: 540 GFTPLHLACKYGKQNVVQILLQ-NGASIDFQGKNDVTPLHVATHYNNPSIVELLLKNGSS 598
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N+ + + + A ++ + LL HGAD +++ G S + + ++D
Sbjct: 599 PNLCARNG--QCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQ 656
Query: 379 RRIVHDMKDMLKRATRKYIKHSH------RTLQSSSMSRHSDDIDKQLNHDDDFYWTDIS 432
+ + + + A + + H L S + H +I ++ +
Sbjct: 657 LLLEYGV---ISAAAKNGLTPLHVAAQEGHVLVSQILLEHGANISERTRN---------- 703
Query: 433 SKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFL------ESCIYGHDDVVSLFLAFG 486
G L A+ G L V ++EN + + ++ GH +++L L
Sbjct: 704 ---GYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHK 760
Query: 487 AQVNMSNKEGQTPLMLSVGRGHVNVVKLL 515
A N K+G T L ++ G+V V++ L
Sbjct: 761 ANPNALTKDGNTALHIASNLGYVTVMESL 789
Score = 58.2 bits (139), Expect = 6e-08
Identities = 38/93 (40%), Positives = 50/93 (52%), Gaps = 3/93 (3%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
R G T L +A G DL K IE D D+ N G TPLH+AA GH I+ LL+R
Sbjct: 700 RTRNGYTPLHMAAHYGHLDLVKFFIENDA-DIEMSSNIGYTPLHQAAQQGHIMIINLLLR 758
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYL 347
+ AN N + D +T L AS G++ V++ L
Sbjct: 759 HKANPNALTKDG--NTALHIASNLGYVTVMESL 789
>Hs7657238 [R] KOG0504 FOG: Ankyrin repeat
Length = 1065
Score = 86.7 bits (213), Expect = 2e-16
Identities = 76/290 (26%), Positives = 126/290 (43%), Gaps = 18/290 (6%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+D GRT L A G + L + ++ DN TPLH AAL GH+ IV LL+
Sbjct: 217 QDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE 276
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDM 374
+ I S D TPL A+ + VK L H P++ + L S +
Sbjct: 277 RNKSGTIPS-DSQGATPLHYAAQSNFAETVKVFLKH---PSVKDDSDLEGRTSFMWAAGK 332
Query: 375 DNDD--RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDIS 432
+DD R ++ D+ KY L ++++S H + L ++ TD+
Sbjct: 333 GSDDVLRTMLSLKSDIDINMADKY---GGTALHAAALSGHVSTVKLLLENNAQVDATDV- 388
Query: 433 SKLGKNKLLKASKEGKLAYVGSYLENGGRPDF------RCFLESCIYGHDDVVSLFLAFG 486
+ L +A + G + + ++ G R D + + G+ DV + +
Sbjct: 389 --MKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENK 446
Query: 487 AQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
N+ + G+TPL + G++N + +L+E ADP DK +TALH++
Sbjct: 447 INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWS 496
>Hs10947042 [M] KOG4177 Ankyrin
Length = 1719
Score = 84.3 bits (207), Expect = 8e-16
Identities = 77/284 (27%), Positives = 122/284 (42%), Gaps = 51/284 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA ++A+ L+ G VN G TPLH A+ G+ +V LL+ GA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ ++ D TPL A+ NGH+ + + LLDHGA GLS I + +D
Sbjct: 265 IETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ +D + DDI L+H + +++ G +
Sbjct: 323 LLLQYDAE--------------------------IDDIT--LDHLTPLH---VAAHCGHH 351
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLAFGAQVNMS 492
++ K L+ G +P+ R +C H V+ L L GA ++
Sbjct: 352 RVAKV-----------LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ G TPL ++ GH+ +VK LL+ GA P ++ + +T LH A
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 80.9 bits (198), Expect = 9e-15
Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 49/281 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G L +A +G + +L+ ++ + GNT LH AAL G +V LV GAN
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
VN QS F TPL A+ H+ VVK+LL++GA+ + G + + ++ +
Sbjct: 104 VNAQSQKGF--TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ----GHE 157
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQ---LNHDDDFYWTDISSKL 435
+ H ++ T+ ++ L + ++ +DD L +D + D+ SK
Sbjct: 158 NVVAH----LINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPN---PDVLSKT 205
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKE 495
G L ++ ++ EN +V L L GA VN + +
Sbjct: 206 GFTPL----------HIAAHYEN-----------------LNVAQLLLNRGASVNFTPQN 238
Query: 496 GQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
G TPL ++ RG+V +V+LLL+ GA + K + T LH A
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 80.5 bits (197), Expect = 1e-14
Identities = 80/294 (27%), Positives = 129/294 (43%), Gaps = 38/294 (12%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G+ ++ ++L+ G +VN Q G TPL+ AA H +V+ L+ NGAN
Sbjct: 78 GNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N+ + D F TPL A GH NVV +L+++G KG + ++ + NDD
Sbjct: 137 QNVATEDGF--TPLAVALQQGHENVVAHLINYG-------TKGKVRLPALHIAA--RNDD 185
Query: 379 RRIVHDM------KDMLKRA--TRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTD 430
R + D+L + T +I + L + + LN +T
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL---------LLNRGASVNFT- 235
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLA 484
+ G L AS+ G + V L+ G + + + E + GH + + L
Sbjct: 236 --PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 485 FGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
GA + K G +P+ ++ H++ V+LLL+ A+ T LH A H
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Score = 73.2 bits (178), Expect = 2e-12
Identities = 72/278 (25%), Positives = 118/278 (41%), Gaps = 39/278 (14%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +A G + +AK L+++ G N + G TPLH A H ++ELL++ GA+++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRR 380
+ TPL AS GH+ +VK LL GA P + N K + + +
Sbjct: 399 AVTESGL--TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 381 IVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKL 440
+ + K K K L ++ H++ + L ++ + ++++ G L
Sbjct: 457 LQNKAKVNAKA------KDDQTPLHCAARIGHTNMVKLLLENNAN---PNLATTAGHTPL 507
Query: 441 LKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPL 500
A++EG + V + LE ++C+ K+G TPL
Sbjct: 508 HIAAREGHVETVLALLEKEAS-------QACM--------------------TKKGFTPL 540
Query: 501 MLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
++ G V V +LLLE A P K T LH A H
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 69.7 bits (169), Expect = 2e-11
Identities = 69/269 (25%), Positives = 113/269 (41%), Gaps = 42/269 (15%)
Query: 250 KRGVHRDAGGR---TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
+R H +A G+ T L +A D+ K L+ G + N G TPLH AA
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQV 615
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+ L++ G + N +S TPL A+ GH +V LL A+ + N GL+ +
Sbjct: 616 EVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673
Query: 367 SIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDF 426
+ +E + D I H + M+ TR + L +S + + L H D
Sbjct: 674 LVAQEGHVPVADVLIKHGV--MVDATTRM----GYTPLHVASHYGNIKLVKFLLQHQAD- 726
Query: 427 YWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFG 486
+ +KLG + L +A+++G H D+V+L L G
Sbjct: 727 --VNAKTKLGYSPLHQAAQQG---------------------------HTDIVTLLLKNG 757
Query: 487 AQVNMSNKEGQTPLMLSVGRGHVNVVKLL 515
A N + +G TPL ++ G+++V +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 67.0 bits (162), Expect = 1e-10
Identities = 68/284 (23%), Positives = 115/284 (39%), Gaps = 18/284 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA +G + L+E++ G TPLH AA G + ELL+ A+
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQAC-MTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N + TPL A + ++++VK LL G P G + + +++ ++
Sbjct: 562 PNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV-- 617
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
R + + + + H Q + + KQ N + + +K G
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN-------LGNKSGLT 670
Query: 439 KLLKASKEGKLAYVGSYLENGGRPD------FRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
L ++EG + +++G D + + YG+ +V L A VN
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
K G +PL + +GH ++V LLL+ GA P + T L A
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 62.4 bits (150), Expect = 3e-09
Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 9/135 (6%)
Query: 250 KRGVHRDAG---GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
K GV DA G T L +A G L K L++ DVN + G +PLH+AA GH+
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA-DVNAKTKLGYSPLHQAAQQGHT 747
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHI---NVVKYLLDHGADPTMVNAKGLS 363
IV LL++NGA+ N S D TPL A G+I +V+K + D + + + +S
Sbjct: 748 DIVTLLLKNGASPNEVSSDG--TTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMS 805
Query: 364 AIESIEEESDMDNDD 378
E+++E D+ D+
Sbjct: 806 FPETVDEILDVSEDE 820
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/115 (32%), Positives = 59/115 (51%), Gaps = 6/115 (5%)
Query: 413 SDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEG------KLAYVGSYLENGGRPDFRC 466
S ++DK L+H + + ++ G N L ASKEG +L + LE +
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 467 FLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
+ + G D+VV + +GA VN +++G TPL ++ H+ VVK LLE GA+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
>Hs10947040 [M] KOG4177 Ankyrin
Length = 1880
Score = 84.3 bits (207), Expect = 8e-16
Identities = 77/284 (27%), Positives = 122/284 (42%), Gaps = 51/284 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA ++A+ L+ G VN G TPLH A+ G+ +V LL+ GA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ ++ D TPL A+ NGH+ + + LLDHGA GLS I + +D
Sbjct: 265 IETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ +D + DDI L+H + +++ G +
Sbjct: 323 LLLQYDAE--------------------------IDDIT--LDHLTPLH---VAAHCGHH 351
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLAFGAQVNMS 492
++ K L+ G +P+ R +C H V+ L L GA ++
Sbjct: 352 RVAKV-----------LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ G TPL ++ GH+ +VK LL+ GA P ++ + +T LH A
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 80.9 bits (198), Expect = 9e-15
Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 49/281 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G L +A +G + +L+ ++ + GNT LH AAL G +V LV GAN
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
VN QS F TPL A+ H+ VVK+LL++GA+ + G + + ++ +
Sbjct: 104 VNAQSQKGF--TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ----GHE 157
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQ---LNHDDDFYWTDISSKL 435
+ H ++ T+ ++ L + ++ +DD L +D + D+ SK
Sbjct: 158 NVVAH----LINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPN---PDVLSKT 205
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKE 495
G L ++ ++ EN +V L L GA VN + +
Sbjct: 206 GFTPL----------HIAAHYEN-----------------LNVAQLLLNRGASVNFTPQN 238
Query: 496 GQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
G TPL ++ RG+V +V+LLL+ GA + K + T LH A
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 80.5 bits (197), Expect = 1e-14
Identities = 80/294 (27%), Positives = 129/294 (43%), Gaps = 38/294 (12%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G+ ++ ++L+ G +VN Q G TPL+ AA H +V+ L+ NGAN
Sbjct: 78 GNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N+ + D F TPL A GH NVV +L+++G KG + ++ + NDD
Sbjct: 137 QNVATEDGF--TPLAVALQQGHENVVAHLINYG-------TKGKVRLPALHIAA--RNDD 185
Query: 379 RRIVHDM------KDMLKRA--TRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTD 430
R + D+L + T +I + L + + LN +T
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL---------LLNRGASVNFT- 235
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLA 484
+ G L AS+ G + V L+ G + + + E + GH + + L
Sbjct: 236 --PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 485 FGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
GA + K G +P+ ++ H++ V+LLL+ A+ T LH A H
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Score = 73.2 bits (178), Expect = 2e-12
Identities = 72/278 (25%), Positives = 118/278 (41%), Gaps = 39/278 (14%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +A G + +AK L+++ G N + G TPLH A H ++ELL++ GA+++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRR 380
+ TPL AS GH+ +VK LL GA P + N K + + +
Sbjct: 399 AVTESGL--TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 381 IVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKL 440
+ + K K K L ++ H++ + L ++ + ++++ G L
Sbjct: 457 LQNKAKVNAKA------KDDQTPLHCAARIGHTNMVKLLLENNAN---PNLATTAGHTPL 507
Query: 441 LKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPL 500
A++EG + V + LE ++C+ K+G TPL
Sbjct: 508 HIAAREGHVETVLALLEKEAS-------QACM--------------------TKKGFTPL 540
Query: 501 MLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
++ G V V +LLLE A P K T LH A H
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 69.7 bits (169), Expect = 2e-11
Identities = 69/269 (25%), Positives = 113/269 (41%), Gaps = 42/269 (15%)
Query: 250 KRGVHRDAGGR---TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
+R H +A G+ T L +A D+ K L+ G + N G TPLH AA
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQV 615
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+ L++ G + N +S TPL A+ GH +V LL A+ + N GL+ +
Sbjct: 616 EVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673
Query: 367 SIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDF 426
+ +E + D I H + M+ TR + L +S + + L H D
Sbjct: 674 LVAQEGHVPVADVLIKHGV--MVDATTRM----GYTPLHVASHYGNIKLVKFLLQHQAD- 726
Query: 427 YWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFG 486
+ +KLG + L +A+++G H D+V+L L G
Sbjct: 727 --VNAKTKLGYSPLHQAAQQG---------------------------HTDIVTLLLKNG 757
Query: 487 AQVNMSNKEGQTPLMLSVGRGHVNVVKLL 515
A N + +G TPL ++ G+++V +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 67.0 bits (162), Expect = 1e-10
Identities = 68/284 (23%), Positives = 115/284 (39%), Gaps = 18/284 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA +G + L+E++ G TPLH AA G + ELL+ A+
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQAC-MTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N + TPL A + ++++VK LL G P G + + +++ ++
Sbjct: 562 PNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV-- 617
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
R + + + + H Q + + KQ N + + +K G
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN-------LGNKSGLT 670
Query: 439 KLLKASKEGKLAYVGSYLENGGRPD------FRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
L ++EG + +++G D + + YG+ +V L A VN
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
K G +PL + +GH ++V LLL+ GA P + T L A
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 62.4 bits (150), Expect = 3e-09
Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 9/135 (6%)
Query: 250 KRGVHRDAG---GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
K GV DA G T L +A G L K L++ DVN + G +PLH+AA GH+
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA-DVNAKTKLGYSPLHQAAQQGHT 747
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHI---NVVKYLLDHGADPTMVNAKGLS 363
IV LL++NGA+ N S D TPL A G+I +V+K + D + + + +S
Sbjct: 748 DIVTLLLKNGASPNEVSSDG--TTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMS 805
Query: 364 AIESIEEESDMDNDD 378
E+++E D+ D+
Sbjct: 806 FPETVDEILDVSEDE 820
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/115 (32%), Positives = 59/115 (51%), Gaps = 6/115 (5%)
Query: 413 SDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEG------KLAYVGSYLENGGRPDFRC 466
S ++DK L+H + + ++ G N L ASKEG +L + LE +
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 467 FLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
+ + G D+VV + +GA VN +++G TPL ++ H+ VVK LLE GA+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
>Hs10947038 [M] KOG4177 Ankyrin
Length = 1881
Score = 84.3 bits (207), Expect = 8e-16
Identities = 77/284 (27%), Positives = 122/284 (42%), Gaps = 51/284 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA ++A+ L+ G VN G TPLH A+ G+ +V LL+ GA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ ++ D TPL A+ NGH+ + + LLDHGA GLS I + +D
Sbjct: 265 IETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ +D + DDI L+H + +++ G +
Sbjct: 323 LLLQYDAE--------------------------IDDIT--LDHLTPLH---VAAHCGHH 351
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLAFGAQVNMS 492
++ K L+ G +P+ R +C H V+ L L GA ++
Sbjct: 352 RVAKV-----------LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ G TPL ++ GH+ +VK LL+ GA P ++ + +T LH A
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 80.9 bits (198), Expect = 9e-15
Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 49/281 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G L +A +G + +L+ ++ + GNT LH AAL G +V LV GAN
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
VN QS F TPL A+ H+ VVK+LL++GA+ + G + + ++ +
Sbjct: 104 VNAQSQKGF--TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ----GHE 157
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQ---LNHDDDFYWTDISSKL 435
+ H ++ T+ ++ L + ++ +DD L +D + D+ SK
Sbjct: 158 NVVAH----LINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPN---PDVLSKT 205
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKE 495
G L ++ ++ EN +V L L GA VN + +
Sbjct: 206 GFTPL----------HIAAHYEN-----------------LNVAQLLLNRGASVNFTPQN 238
Query: 496 GQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
G TPL ++ RG+V +V+LLL+ GA + K + T LH A
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 80.5 bits (197), Expect = 1e-14
Identities = 80/294 (27%), Positives = 129/294 (43%), Gaps = 38/294 (12%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G+ ++ ++L+ G +VN Q G TPL+ AA H +V+ L+ NGAN
Sbjct: 78 GNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N+ + D F TPL A GH NVV +L+++G KG + ++ + NDD
Sbjct: 137 QNVATEDGF--TPLAVALQQGHENVVAHLINYG-------TKGKVRLPALHIAA--RNDD 185
Query: 379 RRIVHDM------KDMLKRA--TRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTD 430
R + D+L + T +I + L + + LN +T
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL---------LLNRGASVNFT- 235
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLA 484
+ G L AS+ G + V L+ G + + + E + GH + + L
Sbjct: 236 --PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 485 FGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
GA + K G +P+ ++ H++ V+LLL+ A+ T LH A H
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Score = 73.2 bits (178), Expect = 2e-12
Identities = 72/278 (25%), Positives = 118/278 (41%), Gaps = 39/278 (14%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +A G + +AK L+++ G N + G TPLH A H ++ELL++ GA+++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRR 380
+ TPL AS GH+ +VK LL GA P + N K + + +
Sbjct: 399 AVTESGL--TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 381 IVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKL 440
+ + K K K L ++ H++ + L ++ + ++++ G L
Sbjct: 457 LQNKAKVNAKA------KDDQTPLHCAARIGHTNMVKLLLENNAN---PNLATTAGHTPL 507
Query: 441 LKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPL 500
A++EG + V + LE ++C+ K+G TPL
Sbjct: 508 HIAAREGHVETVLALLEKEAS-------QACM--------------------TKKGFTPL 540
Query: 501 MLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
++ G V V +LLLE A P K T LH A H
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 69.7 bits (169), Expect = 2e-11
Identities = 69/269 (25%), Positives = 113/269 (41%), Gaps = 42/269 (15%)
Query: 250 KRGVHRDAGGR---TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
+R H +A G+ T L +A D+ K L+ G + N G TPLH AA
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQV 615
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+ L++ G + N +S TPL A+ GH +V LL A+ + N GL+ +
Sbjct: 616 EVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673
Query: 367 SIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDF 426
+ +E + D I H + M+ TR + L +S + + L H D
Sbjct: 674 LVAQEGHVPVADVLIKHGV--MVDATTRM----GYTPLHVASHYGNIKLVKFLLQHQAD- 726
Query: 427 YWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFG 486
+ +KLG + L +A+++G H D+V+L L G
Sbjct: 727 --VNAKTKLGYSPLHQAAQQG---------------------------HTDIVTLLLKNG 757
Query: 487 AQVNMSNKEGQTPLMLSVGRGHVNVVKLL 515
A N + +G TPL ++ G+++V +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 67.0 bits (162), Expect = 1e-10
Identities = 68/284 (23%), Positives = 115/284 (39%), Gaps = 18/284 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA +G + L+E++ G TPLH AA G + ELL+ A+
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQAC-MTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N + TPL A + ++++VK LL G P G + + +++ ++
Sbjct: 562 PNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV-- 617
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
R + + + + H Q + + KQ N + + +K G
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN-------LGNKSGLT 670
Query: 439 KLLKASKEGKLAYVGSYLENGGRPD------FRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
L ++EG + +++G D + + YG+ +V L A VN
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
K G +PL + +GH ++V LLL+ GA P + T L A
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 62.4 bits (150), Expect = 3e-09
Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 9/135 (6%)
Query: 250 KRGVHRDAG---GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
K GV DA G T L +A G L K L++ DVN + G +PLH+AA GH+
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA-DVNAKTKLGYSPLHQAAQQGHT 747
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHI---NVVKYLLDHGADPTMVNAKGLS 363
IV LL++NGA+ N S D TPL A G+I +V+K + D + + + +S
Sbjct: 748 DIVTLLLKNGASPNEVSSDG--TTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMS 805
Query: 364 AIESIEEESDMDNDD 378
E+++E D+ D+
Sbjct: 806 FPETVDEILDVSEDE 820
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/115 (32%), Positives = 59/115 (51%), Gaps = 6/115 (5%)
Query: 413 SDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEG------KLAYVGSYLENGGRPDFRC 466
S ++DK L+H + + ++ G N L ASKEG +L + LE +
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 467 FLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
+ + G D+VV + +GA VN +++G TPL ++ H+ VVK LLE GA+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
>Hs10947036 [M] KOG4177 Ankyrin
Length = 1856
Score = 84.3 bits (207), Expect = 8e-16
Identities = 77/284 (27%), Positives = 122/284 (42%), Gaps = 51/284 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA ++A+ L+ G VN G TPLH A+ G+ +V LL+ GA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ ++ D TPL A+ NGH+ + + LLDHGA GLS I + +D
Sbjct: 265 IETKTKDEL--TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
+ +D + DDI L+H + +++ G +
Sbjct: 323 LLLQYDAE--------------------------IDDIT--LDHLTPLH---VAAHCGHH 351
Query: 439 KLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLAFGAQVNMS 492
++ K L+ G +P+ R +C H V+ L L GA ++
Sbjct: 352 RVAKV-----------LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ G TPL ++ GH+ +VK LL+ GA P ++ + +T LH A
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 80.9 bits (198), Expect = 9e-15
Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 49/281 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G L +A +G + +L+ ++ + GNT LH AAL G +V LV GAN
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
VN QS F TPL A+ H+ VVK+LL++GA+ + G + + ++ +
Sbjct: 104 VNAQSQKGF--TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ----GHE 157
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQ---LNHDDDFYWTDISSKL 435
+ H ++ T+ ++ L + ++ +DD L +D + D+ SK
Sbjct: 158 NVVAH----LINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPN---PDVLSKT 205
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKE 495
G L ++ ++ EN +V L L GA VN + +
Sbjct: 206 GFTPL----------HIAAHYEN-----------------LNVAQLLLNRGASVNFTPQN 238
Query: 496 GQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
G TPL ++ RG+V +V+LLL+ GA + K + T LH A
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 80.5 bits (197), Expect = 1e-14
Identities = 80/294 (27%), Positives = 129/294 (43%), Gaps = 38/294 (12%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G+ ++ ++L+ G +VN Q G TPL+ AA H +V+ L+ NGAN
Sbjct: 78 GNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N+ + D F TPL A GH NVV +L+++G KG + ++ + NDD
Sbjct: 137 QNVATEDGF--TPLAVALQQGHENVVAHLINYG-------TKGKVRLPALHIAA--RNDD 185
Query: 379 RRIVHDM------KDMLKRA--TRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTD 430
R + D+L + T +I + L + + LN +T
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL---------LLNRGASVNFT- 235
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLA 484
+ G L AS+ G + V L+ G + + + E + GH + + L
Sbjct: 236 --PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 485 FGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
GA + K G +P+ ++ H++ V+LLL+ A+ T LH A H
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Score = 73.2 bits (178), Expect = 2e-12
Identities = 72/278 (25%), Positives = 118/278 (41%), Gaps = 39/278 (14%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +A G + +AK L+++ G N + G TPLH A H ++ELL++ GA+++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRR 380
+ TPL AS GH+ +VK LL GA P + N K + + +
Sbjct: 399 AVTESGL--TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 381 IVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKL 440
+ + K K K L ++ H++ + L ++ + ++++ G L
Sbjct: 457 LQNKAKVNAKA------KDDQTPLHCAARIGHTNMVKLLLENNAN---PNLATTAGHTPL 507
Query: 441 LKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPL 500
A++EG + V + LE ++C+ K+G TPL
Sbjct: 508 HIAAREGHVETVLALLEKEAS-------QACM--------------------TKKGFTPL 540
Query: 501 MLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANH 538
++ G V V +LLLE A P K T LH A H
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Score = 69.7 bits (169), Expect = 2e-11
Identities = 69/269 (25%), Positives = 113/269 (41%), Gaps = 42/269 (15%)
Query: 250 KRGVHRDAGGR---TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
+R H +A G+ T L +A D+ K L+ G + N G TPLH AA
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQV 615
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+ L++ G + N +S TPL A+ GH +V LL A+ + N GL+ +
Sbjct: 616 EVARSLLQYGGSANAESVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLH 673
Query: 367 SIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDF 426
+ +E + D I H + M+ TR + L +S + + L H D
Sbjct: 674 LVAQEGHVPVADVLIKHGV--MVDATTRM----GYTPLHVASHYGNIKLVKFLLQHQAD- 726
Query: 427 YWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFG 486
+ +KLG + L +A+++G H D+V+L L G
Sbjct: 727 --VNAKTKLGYSPLHQAAQQG---------------------------HTDIVTLLLKNG 757
Query: 487 AQVNMSNKEGQTPLMLSVGRGHVNVVKLL 515
A N + +G TPL ++ G+++V +L
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 67.0 bits (162), Expect = 1e-10
Identities = 68/284 (23%), Positives = 115/284 (39%), Gaps = 18/284 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA +G + L+E++ G TPLH AA G + ELL+ A+
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQAC-MTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
N + TPL A + ++++VK LL G P G + + +++ ++
Sbjct: 562 PNAAGKNGL--TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV-- 617
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKN 438
R + + + + H Q + + KQ N + + +K G
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN-------LGNKSGLT 670
Query: 439 KLLKASKEGKLAYVGSYLENGGRPD------FRCFLESCIYGHDDVVSLFLAFGAQVNMS 492
L ++EG + +++G D + + YG+ +V L A VN
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 493 NKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
K G +PL + +GH ++V LLL+ GA P + T L A
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 62.4 bits (150), Expect = 3e-09
Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 9/135 (6%)
Query: 250 KRGVHRDAG---GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
K GV DA G T L +A G L K L++ DVN + G +PLH+AA GH+
Sbjct: 689 KHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA-DVNAKTKLGYSPLHQAAQQGHT 747
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHI---NVVKYLLDHGADPTMVNAKGLS 363
IV LL++NGA+ N S D TPL A G+I +V+K + D + + + +S
Sbjct: 748 DIVTLLLKNGASPNEVSSDG--TTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMS 805
Query: 364 AIESIEEESDMDNDD 378
E+++E D+ D+
Sbjct: 806 FPETVDEILDVSEDE 820
Score = 53.5 bits (127), Expect = 2e-06
Identities = 37/115 (32%), Positives = 59/115 (51%), Gaps = 6/115 (5%)
Query: 413 SDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEG------KLAYVGSYLENGGRPDFRC 466
S ++DK L+H + + ++ G N L ASKEG +L + LE +
Sbjct: 22 SGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA 81
Query: 467 FLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
+ + G D+VV + +GA VN +++G TPL ++ H+ VVK LLE GA+
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
>7301133 [T] KOG4369 RTK signaling protein MASK/UNC-44
Length = 2441
Score = 81.3 bits (199), Expect = 7e-15
Identities = 78/270 (28%), Positives = 114/270 (41%), Gaps = 53/270 (19%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +AC G +L + LI G ++ +D G TPL AA GH +V++L+++ A +
Sbjct: 755 TALTLACAGGHEELVELLINR-GANIEHRDKKGFTPLILAATAGHDKVVDILLKHSAELE 813
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRR 380
QS + DTPL A + G VV+ LL GA N + R
Sbjct: 814 AQS-ERTKDTPLSLACSGGRYEVVELLLSVGA-----------------------NKEHR 849
Query: 381 IVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKL 440
V D + A+ Y+ L H +I+ + SKLG + L
Sbjct: 850 NVSDYTPLSLAASGGYVNIIKLLLS------HGAEINSR-----------TGSKLGISPL 892
Query: 441 LKASKEGKLAYVGSYLENGGRPDFRCFLE---------SCIYGHDDVVSLFLAFGAQVNM 491
+ A+ G V L+ G D +E +C G +VVSL L A V
Sbjct: 893 MLAAMNGHTPAVKLLLDQGS--DINAQIETNRNTALTLACFQGRHEVVSLLLDRRANVEH 950
Query: 492 SNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
K G TPLM + G++ V ++LL+ GAD
Sbjct: 951 RAKTGLTPLMEAASGGYIEVGRVLLDKGAD 980
Score = 78.2 bits (191), Expect = 6e-14
Identities = 75/291 (25%), Positives = 123/291 (41%), Gaps = 22/291 (7%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
HRD G T L +A G + L++ + +TPL A G +VELL+
Sbjct: 781 HRDKKGFTPLILAATAGHDKVVDILLKHSAELEAQSERTKDTPLSLACSGGRYEVVELLL 840
Query: 314 RNGANV---NIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEE 370
GAN N+ Y TPL A++ G++N++K LL HGA+ +N++ S +
Sbjct: 841 SVGANKEHRNVSDY-----TPLSLAASGGYVNIIKLLLSHGAE---INSRTGSKLGISPL 892
Query: 371 ESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTD 430
N V + D + + + L + + + L+ + +
Sbjct: 893 MLAAMNGHTPAVKLLLDQGSDINAQIETNRNTALTLACFQGRHEVVSLLLDRRAN---VE 949
Query: 431 ISSKLGKNKLLKASKEGKLAYVGSYLENGGR------PDFR--CFLESCIYGHDDVVSLF 482
+K G L++A+ G + L+ G P R + GH V L
Sbjct: 950 HRAKTGLTPLMEAASGGYIEVGRVLLDKGADVNAAPVPTSRDTALTIAADKGHQKFVELL 1009
Query: 483 LAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTAL 533
L+ A V + NK+G +PL L+ GH++VV+LL + AD D R+ + L
Sbjct: 1010 LSRNASVEVKNKKGNSPLWLAAHGGHLSVVELLYDHNADIDSQDNRRVSCL 1060
Score = 60.1 bits (144), Expect = 2e-08
Identities = 43/151 (28%), Positives = 71/151 (46%), Gaps = 14/151 (9%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +AC +G++++ L++ +V + G TPL EAA G+ + +L+ GA+VN
Sbjct: 924 TALTLACFQGRHEVVSLLLDRRA-NVEHRAKTGLTPLMEAASGGYIEVGRVLLDKGADVN 982
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG------------LSAIESI 368
DT L A+ GH V+ LL A + N KG LS +E +
Sbjct: 983 AAPVPTSRDTALTIAADKGHQKFVELLLSRNASVEVKNKKGNSPLWLAAHGGHLSVVELL 1042
Query: 369 -EEESDMDNDDRRIVHDMKDMLKRATRKYIK 398
+ +D+D+ D R V + ++ K +K
Sbjct: 1043 YDHNADIDSQDNRRVSCLMAAFRKGHTKIVK 1073
>CE26238_1 [M] KOG4177 Ankyrin
Length = 1294
Score = 78.6 bits (192), Expect = 4e-14
Identities = 85/341 (24%), Positives = 147/341 (42%), Gaps = 81/341 (23%)
Query: 255 RDAGGRTKLQIACDKGKYDLAK---KLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVEL 311
RD G+T L +A + D+ K K+ + + D+ G T H AA+ G A+V
Sbjct: 969 RDDKGQTPLHLAAENDFPDVVKLFLKMRNNNRSVLTAIDHNGFTCAHIAAMKGSLAVVRE 1028
Query: 312 LVRNGANVNIQSYDMFLD-TPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE---- 366
L+ + IQ+ L+ T L A+A GH N+VK LL++GA+ N+ G++A+
Sbjct: 1029 LMMIDKPMVIQAKTKTLEATTLHMAAAGGHANIVKILLENGANAEDENSHGMTALHLGAK 1088
Query: 367 ----SIEEESDMDNDDRRIVHDMKDMLKRATRK--------------------YIKHSHR 402
SI E D K + KR +RK +KH
Sbjct: 1089 NGFISILEAFD------------KILWKRCSRKTGLNALHIAAFYGNSDFVNEMLKHVQA 1136
Query: 403 TLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLK-------------------- 442
T++S ++ ++K+ + + F ++++ G + L++
Sbjct: 1137 TVRSEPPI-YNHHVNKEFSTEYGFTPLHLAAQSGHDSLVRMLLNQGVQVDATSTTMNVIP 1195
Query: 443 ---ASKEGKLAYVGSYLENG----------GRPDFRCFLESCIYGHDDVVSLFLAFGAQV 489
A+++G +A VG L GR ++ GH ++VSL +A G+ +
Sbjct: 1196 LHLAAQQGHIAVVGMLLSRSTQQQHAKDWRGRTPLHLAAQN---GHYEMVSLLIAQGSNI 1252
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKK 530
N+ ++ G T L + GH++VVKL +++ ADP K K
Sbjct: 1253 NVMDQNGWTGLHFATRAGHLSVVKLFIDSSADPLAETKEGK 1293
Score = 58.5 bits (140), Expect = 5e-08
Identities = 76/283 (26%), Positives = 121/283 (41%), Gaps = 45/283 (15%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G + L AC +G +A L++ ++ D G T LH AA NGH ++V LL+++ A
Sbjct: 840 GWSPLLEACARGHSGVANILLKHHAR-IDVFDEMGRTALHLAAFNGHLSLVHLLLQHKAF 898
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLL-DHGADPTMVNAKGLSAIESIEEESDMDND 377
VN +S + PL A+ +GH+ VV L+ DHGA A+E+I D
Sbjct: 899 VNSKSKTG--EAPLHLAAQHGHVKVVNVLVQDHGA-----------ALEAI------TLD 939
Query: 378 DRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNH---DDDFYWTDISSK 434
++ +H + A S L + DD + H ++DF D+
Sbjct: 940 NQTALHFAAKFGQLAV------SQTLLALGANPNARDDKGQTPLHLAAENDF--PDVV-- 989
Query: 435 LGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNK 494
KL + + + + NG F C + + G VV + + + K
Sbjct: 990 ----KLFLKMRNNNRSVLTAIDHNG----FTCAHIAAMKGSLAVVRELMMIDKPMVIQAK 1041
Query: 495 E---GQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALH 534
T L ++ GH N+VK+LLE GA+ + + TALH
Sbjct: 1042 TKTLEATTLHMAAAGGHANIVKILLENGANAEDENSHGMTALH 1084
Score = 55.8 bits (133), Expect = 3e-07
Identities = 75/313 (23%), Positives = 127/313 (39%), Gaps = 46/313 (14%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEED-GYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGA 317
G L A G D+ K LI DV +DN T LH A +G +++VE L+ +GA
Sbjct: 579 GALGLHSAAAAGFNDVVKMLIARGTNVDVRTRDNY--TALHVAVQSGKASVVETLLGSGA 636
Query: 318 NVNIQSYDMFLDTPLIDASANG--HINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
+++++ ++ I AS NG + LL G P + G + + + D
Sbjct: 637 DIHVKGGELGQTALHIAASLNGAESRDCAMMLLKSGGQPDVAQMDGETCLHIAARSGNKD 696
Query: 376 --------NDDRRIVHDM---------KDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDK 418
N D +I + K A +KH L + H
Sbjct: 697 IMRLLLDENADSKISSKIGETPLQVAAKSCNFEAASMILKHLSEVLTQEQLKEH------ 750
Query: 419 QLNH--DDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFL--ESCIY- 473
+NH +D F ++++ + +L ++ KL V ++ GG + E+ ++
Sbjct: 751 -VNHRTNDGFTALHYAAEIEQRQLHFPGEDAKL--VNLLIDYGGMVEMPSLNANETAMHM 807
Query: 474 ----GHDDVVSLFL----AFGAQV--NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQ 523
G+ V+ + A Q+ N +K G +PL+ + RGH V +LL+ A
Sbjct: 808 AARSGNQAVLLAMVNKIGAGAVQIVQNKQSKNGWSPLLEACARGHSGVANILLKHHARID 867
Query: 524 KTDKRKKTALHYA 536
D+ +TALH A
Sbjct: 868 VFDEMGRTALHLA 880
>Hs4505319 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 982
Score = 77.0 bits (188), Expect = 1e-13
Identities = 76/333 (22%), Positives = 145/333 (42%), Gaps = 56/333 (16%)
Query: 216 VKHYNEHKRKSSSIENSSNHKKQKHSAGKKIPKTKRGVHRD-----AGGRTKLQ------ 264
++H + +S+ + + ++ + S ++ P +RG R R + +
Sbjct: 4 LEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFL 63
Query: 265 IACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSY 324
AC G D +KL+ G D+N + G T LH+A ++ + +V+ LV N ANVN Q
Sbjct: 64 AACSSGDTDEVRKLLAR-GADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
Query: 325 DMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHD 384
+ + TPL A++ G++N+ +Y ++HGA +VN++G + EE +
Sbjct: 123 EGW--TPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPA------------ 168
Query: 385 MKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKAS 444
MKD+L +K Q + + + ++Q+ D W + GK + ++ +
Sbjct: 169 MKDLLLEQVKK---------QGIDLEQSRKEEEQQMLQDAR-QWLN----SGKIEDVRQA 214
Query: 445 KEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSV 504
+ G A + G+ +V+ L + G ++N+ + +G TPL +
Sbjct: 215 RSGATA----------------LHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAA 258
Query: 505 GRGHVNVVKLLLEAGADPQKTDKRKKTALHYAN 537
G +L EA D +K +T A+
Sbjct: 259 HWGVKEACSILAEALCDMDIRNKLGQTPFDVAD 291
>Hs14195601 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 998
Score = 77.0 bits (188), Expect = 1e-13
Identities = 76/333 (22%), Positives = 145/333 (42%), Gaps = 56/333 (16%)
Query: 216 VKHYNEHKRKSSSIENSSNHKKQKHSAGKKIPKTKRGVHRD-----AGGRTKLQ------ 264
++H + +S+ + + ++ + S ++ P +RG R R + +
Sbjct: 4 LEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFL 63
Query: 265 IACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSY 324
AC G D +KL+ G D+N + G T LH+A ++ + +V+ LV N ANVN Q
Sbjct: 64 AACSSGDTDEVRKLLAR-GADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
Query: 325 DMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHD 384
+ + TPL A++ G++N+ +Y ++HGA +VN++G + EE +
Sbjct: 123 EGW--TPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPA------------ 168
Query: 385 MKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKAS 444
MKD+L +K Q + + + ++Q+ D W + GK + ++ +
Sbjct: 169 MKDLLLEQVKK---------QGIDLEQSRKEEEQQMLQDAR-QWLN----SGKIEDVRQA 214
Query: 445 KEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSV 504
+ G A + G+ +V+ L + G ++N+ + +G TPL +
Sbjct: 215 RSGATA----------------LHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAA 258
Query: 505 GRGHVNVVKLLLEAGADPQKTDKRKKTALHYAN 537
G +L EA D +K +T A+
Sbjct: 259 HWGVKEACSILAEALCDMDIRNKLGQTPFDVAD 291
>7300995 [T] KOG0507 CASK-interacting adaptor protein (caskin) and related
proteins with ankyrin repeats and SAM domain
Length = 1315
Score = 77.0 bits (188), Expect = 1e-13
Identities = 81/320 (25%), Positives = 130/320 (40%), Gaps = 68/320 (21%)
Query: 225 KSSSIENSSNHKKQKHSAGKKIPKTKRGVH---RDAGGRTKLQIACDKGKYDLAKKLIEE 281
++ +I + QK + +RG +D+GG + L AC G D+ + L+
Sbjct: 12 RNGNISHIEKVLTQKAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNGHEDIVRLLLAH 71
Query: 282 DGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNG---ANVNIQSYDMFLDTPLIDASAN 338
+ N D+ G++PLH AA G + IV LL+ + A+ N+Q+ + +TPL A+ +
Sbjct: 72 EA-SPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQ--ETPLHCAAQH 128
Query: 339 GHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIK 398
GH + LL H ADP M N++G + ++ + + ML RA + I
Sbjct: 129 GHTGALALLLHHDADPNMRNSRGETPLDLAAQYGRL---------QAVQMLIRAHPELIA 179
Query: 399 HSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLEN 458
H LG L + + +
Sbjct: 180 H-----------------------------------LGTEALERGTPSP---------SS 195
Query: 459 GGRPDFRCFLESCIY-----GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVK 513
P F +C++ GH VV + L+ G VN+ G T L + G NVV+
Sbjct: 196 PASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSG-TALHEAALCGKENVVR 254
Query: 514 LLLEAGADPQKTDKRKKTAL 533
LL+AG + TD +TAL
Sbjct: 255 TLLKAGINLNATDNEGRTAL 274
>Hs20472035 [R] KOG0504 FOG: Ankyrin repeat
Length = 361
Score = 75.9 bits (185), Expect = 3e-13
Identities = 71/288 (24%), Positives = 120/288 (41%), Gaps = 20/288 (6%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L A G D+ L E G D+ + PLHEAA GH V L+ GA
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAA 96
Query: 319 VN-IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDND 377
V+ ++ D TPL+ A ++ V++ L++HGA+P + N G ++ E
Sbjct: 97 VDCLKKADW---TPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHIASREG----- 148
Query: 378 DRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGK 437
D I+ + + A + K L +++M H + + L Y D G
Sbjct: 149 DPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHGHLEAVKVLLKRCQ--YEPDYRDNCGV 206
Query: 438 NKLLKASKEGKLAYVGSYLENGG-------RPDFRCFLESCIYGHDDVVSLFLA-FGAQV 489
L+ A + G + L+ G + + + G D+ + ++ G V
Sbjct: 207 TALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLVSELGVDV 266
Query: 490 NM-SNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
++ + T L + GH + ++ LL GAD D++ ++ALH A
Sbjct: 267 DVRATSTHLTALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLA 314
Score = 55.5 bits (132), Expect = 4e-07
Identities = 37/113 (32%), Positives = 59/113 (51%), Gaps = 2/113 (1%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
+RD G T L A G D+A+ L++E G ++ +D+ G LH AA+ G + LV
Sbjct: 200 YRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQDEAIRFLV 259
Query: 314 RN-GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
G +V++++ L T L A+ GH + ++ LL GAD + K SA+
Sbjct: 260 SELGVDVDVRATSTHL-TALHYAAKEGHTSTIQTLLSLGADINSKDEKNRSAL 311
>Hs15718772_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 813
Score = 75.5 bits (184), Expect = 4e-13
Identities = 58/177 (32%), Positives = 87/177 (48%), Gaps = 10/177 (5%)
Query: 238 QKHSAGKKIPKTKRGVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPL 297
Q H +K K R R+ G T L AC +G+ + L+ + G+ +N +D G TPL
Sbjct: 352 QGHLGRRKGSKWNR---RNDMGETLLHRACIEGQLRRVQDLVRQ-GHPLNPRDYCGWTPL 407
Query: 298 HEAALNGHSAIVELLVRNGANVNIQSYDMFLD-TPLIDASANGHINVVKYLLDHGADPTM 356
HEA GH IV L+ +GA V+ TPL DA GH V + LL+ GA T+
Sbjct: 408 HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL 467
Query: 357 VNAKGLSAIESIEE-----ESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSS 408
KGLS +E++++ D+D + R+ M+ +L+ A HS + + S
Sbjct: 468 RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPS 524
>7294199_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 708
Score = 75.5 bits (184), Expect = 4e-13
Identities = 78/289 (26%), Positives = 126/289 (42%), Gaps = 57/289 (19%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T LQ A G ++ + L+ DV +D G+ +H AA +A++E+L + GA+
Sbjct: 65 GHTALQAASQNGHIEVIQVLLRH-AVDVEIEDKDGDRAVHHAAFGDEAAVIEILAKAGAD 123
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI-ESIEEESDMDND 377
+N ++ T L A GH+NVVK LL G P++ +++G + + ++I +E D
Sbjct: 124 LNARNKRR--QTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAISKEHD---- 177
Query: 378 DRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGK 437
+ML S + DI LN+++ F
Sbjct: 178 ---------EML-----------------SLLLDFGADIT--LNNNNGF----------- 198
Query: 438 NKLLKASKEGKLAYVGSYLENGGRP---------DFRCFLESCIYGHDDVVSLFLAFG-A 487
N L A+ +G + + L RP + + + H ++ L + G A
Sbjct: 199 NALHHAALKGNPSAMKILLTKTNRPWIVEEKKDDGYTALHLAALNNHVEIAELLVHMGKA 258
Query: 488 QVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
++ N QT L L+V R HV +VKLL++ GAD DK T LH A
Sbjct: 259 NMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPDKDGDTPLHEA 307
>Hs7705748 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 835
Score = 75.1 bits (183), Expect = 5e-13
Identities = 75/266 (28%), Positives = 116/266 (43%), Gaps = 35/266 (13%)
Query: 258 GGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGA 317
GG T L IA G + A L++ G +VN QD TPLH AA GH + LL++ GA
Sbjct: 133 GGLTALHIATIAGHLEAADVLLQH-GANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191
Query: 318 NVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDND 377
+VN+ D PL ASA G +N+ K L++ G+ VNA+ DN+
Sbjct: 192 DVNVSG--EVGDRPLHLASAKGFLNIAKLLMEEGSKAD-VNAQ--------------DNE 234
Query: 378 DRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGK 437
D +H KY+ S +Q ++ + D ++ F ++ K
Sbjct: 235 DHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKF-------EVAK 287
Query: 438 NKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHD-DVVSLFLAFGA-QVNMSNKE 495
++++ S L + E F +C YG D+V L +N ++
Sbjct: 288 -EIIQISGTESLTKENIFSET-------AFHSACTYGKSIDLVKFLLDQNVININHQGRD 339
Query: 496 GQTPLMLSVGRGHVNVVKLLLEAGAD 521
G T L + GH+ +V+ LL+ GAD
Sbjct: 340 GHTGLHSACYHGHIRLVQFLLDNGAD 365
Score = 57.8 bits (138), Expect = 8e-08
Identities = 38/102 (37%), Positives = 57/102 (55%), Gaps = 5/102 (4%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNA-GNTPLHEAALNGHSA--IVELLVRN 315
G T L +AC GK+++AK++I+ G + ++N T H A G S + LL +N
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMV 357
N+N Q D T L A +GHI +V++LLD+GAD +V
Sbjct: 330 VININHQGRDGH--TGLHSACYHGHIRLVQFLLDNGADMNLV 369
Score = 56.2 bits (134), Expect = 2e-07
Identities = 28/67 (41%), Positives = 38/67 (55%), Gaps = 2/67 (2%)
Query: 473 YGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAG--ADPQKTDKRKK 530
YGH+ V L L FGA VN+S + G PL L+ +G +N+ KLL+E G AD D
Sbjct: 177 YGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDH 236
Query: 531 TALHYAN 537
LH+ +
Sbjct: 237 VPLHFCS 243
Score = 55.8 bits (133), Expect = 3e-07
Identities = 70/272 (25%), Positives = 112/272 (40%), Gaps = 44/272 (16%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+DA T L IA G ++ +L+ + G DVN G+ PLH A+ G I +LL+
Sbjct: 163 QDAVFFTPLHIAAYYG-HEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 221
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLL--DHGADPTMVNAKGLSAIESIEEES 372
G+ ++ + D PL S GH ++VKYLL D P +VN G + +
Sbjct: 222 EGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNG 281
Query: 373 DMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDIS 432
+ I + L T++ I S S+ S D+ K L
Sbjct: 282 KFEVAKEIIQISGTESL---TKENI-FSETAFHSACTYGKSIDLVKFL------------ 325
Query: 433 SKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNM- 491
L +N ++ + +G+ + G + +C +GH +V L GA +N+
Sbjct: 326 --LDQN-VININHQGRDGHTGLH-------------SACYHGHIRLVQFLLDNGADMNLV 369
Query: 492 --------SNKEGQTPLMLSVGRGHVNVVKLL 515
K+ QT LM + +GH +V LL
Sbjct: 370 ACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLL 401
>7295200_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 458
Score = 74.7 bits (182), Expect = 6e-13
Identities = 50/151 (33%), Positives = 83/151 (54%), Gaps = 11/151 (7%)
Query: 253 VHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELL 312
+ ++ G T+L AC G +L ++LI++ G+ VN +D+AG PLHEA +G+ IVELL
Sbjct: 6 IKKNNKGETQLHQACISGNLELVRRLIDQ-GHTVNVRDHAGWLPLHEACNHGYREIVELL 64
Query: 313 VRNGANVNIQ-----SYDMFLDTPLIDASANGHINVVKYLLDHGADPTM---VNAKGLSA 364
+ GA I S D TPL DA +NG ++V + LLD GAD T+ N ++
Sbjct: 65 LDKGAASAINDKGGTSCDGI--TPLFDACSNGFLDVAELLLDRGADATVRTDYNETCIAG 122
Query: 365 IESIEEESDMDNDDRRIVHDMKDMLKRATRK 395
++ + + + + ++ +++ L R K
Sbjct: 123 LDKWRQGAQLVDGEQAQYAQLRERLLRTLSK 153
>7291279 [R] KOG0502 Integral membrane ankyrin-repeat protein Kidins220
(protein kinase D substrate)
Length = 1498
Score = 74.3 bits (181), Expect = 8e-13
Identities = 79/286 (27%), Positives = 116/286 (39%), Gaps = 51/286 (17%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
HRD GG T L A +G +L + L+++ G D N N L AA G+ IVELLV
Sbjct: 122 HRDMGGWTSLMWAAYRGHTELVRLLLDK-GADGNAHGNYHLGALLWAAGRGYKDIVELLV 180
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESD 373
+ GA VN+ D + T L+ A G++ +V LL GA+ V+ G+
Sbjct: 181 QRGAKVNVG--DKYGTTALVWACRRGNVEIVDTLLKAGAN---VDTAGM----------- 224
Query: 374 MDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISS 433
+S L ++ H+D + L + D
Sbjct: 225 -------------------------YSWTPLLVAAAGGHTDCVSSILEKKPNVNALD--- 256
Query: 434 KLGKNKLLKASKEG------KLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGA 487
K G L AS+EG L G+Y+ R + + GH VV L A
Sbjct: 257 KDGMTALCIASREGFQDIAASLIAAGAYINIQDRGADTPLIHAVKAGHRTVVEALLKKHA 316
Query: 488 QVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTAL 533
V++ K+ +T + +V +GH +VKLLL D + K T L
Sbjct: 317 DVDIQGKDRKTAIYTAVEKGHTPIVKLLLATNPDLESATKDGDTPL 362
>Hs4505317 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 1030
Score = 73.9 bits (180), Expect = 1e-12
Identities = 70/299 (23%), Positives = 130/299 (43%), Gaps = 53/299 (17%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
AC G D KL+ G D+N + G T LH+A ++ + +V+ LV NGAN+N +
Sbjct: 47 ACSSGDTDEVLKLLHR-GADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNE 105
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDM 385
++ PL A++ G++++ ++L+ GA VN++G + ++ EEE+ M
Sbjct: 106 GWI--PLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEA------------M 151
Query: 386 KDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGK---NKLLK 442
+++L+ + ++R DI+ ++ D L N +
Sbjct: 152 EELLQ----------------NEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRH 195
Query: 443 ASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLML 502
A G +V + G+ +V+ L + G VN+ + +G TPL
Sbjct: 196 AKSGGTALHV-----------------AAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHA 238
Query: 503 SVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTD--PDEVNLLKAAVRAK 559
+ G ++L++ D + +K +TA A+ LG + + NLL + R K
Sbjct: 239 AAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDK 297
>Hs20538133 [R] KOG0504 FOG: Ankyrin repeat
Length = 899
Score = 73.6 bits (179), Expect = 1e-12
Identities = 74/298 (24%), Positives = 127/298 (41%), Gaps = 57/298 (19%)
Query: 253 VHRDA--GGRTKLQIACDKGKYDLAKKLIEEDGYDV-NDQDNAGN-TPLHEAALNGHSAI 308
VH A G R LQ+ + D+ L+E G D+ +D DN +PLH AA +GH
Sbjct: 355 VHYSAAYGHRLCLQLIASETPLDV---LMETSGTDMLSDSDNRATISPLHLAAYHGHHQA 411
Query: 309 VELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESI 368
+E+LV++ ++++++ TPL A+ GH+ V L++ GA +
Sbjct: 412 LEVLVQSLLDLDVRNSSG--RTPLDLAAFKGHVECVDVLINQGASILV------------ 457
Query: 369 EEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYW 428
KD + + T + +++ + HS+ + + + +
Sbjct: 458 -----------------KDYILKRT---------PIHAAATNGHSECLRLLIGNAEPQNA 491
Query: 429 TDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFR------CFLESCIYGHDDVVSLF 482
DI G+ L+ + G V S L G D + + GH++ V
Sbjct: 492 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 551
Query: 483 LAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAG----ADPQKTDKRKKTALHYA 536
L GA+ + + G+TP+ LS GH+ V+ LL++ A+P D TALH+A
Sbjct: 552 LQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWA 609
Score = 72.0 bits (175), Expect = 4e-12
Identities = 71/267 (26%), Positives = 117/267 (43%), Gaps = 18/267 (6%)
Query: 277 KLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDAS 336
KL+ G ++N D +H AA GH +V+LLV +GA V + + TPL A+
Sbjct: 3 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSY--TPLHAAA 60
Query: 337 ANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKY 396
++G I+VVKYLLD G D NA G + + N +V+++ D +K
Sbjct: 61 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA-----CYNGQDVVVNELIDCGAIVNQKN 115
Query: 397 IKHSHRTLQSSSMSRHSD-DIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSY 455
K L ++ S H ++ + + D ++ SK GK L + G+ + +
Sbjct: 116 EK-GFTPLHFAAASTHGALCLELLVGNGAD---VNMKSKDGKTPLHMTALHGRFSRSQTI 171
Query: 456 LENGGRPDFR------CFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHV 509
+++G D + YGH+ +++ + GA G PL L+ G
Sbjct: 172 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 231
Query: 510 NVVKLLLEAGADPQKTDKRKKTALHYA 536
+ + LL +G D D +T LH A
Sbjct: 232 DCCRKLLSSGFDIDTPDDFGRTCLHAA 258
Score = 69.7 bits (169), Expect = 2e-11
Identities = 84/335 (25%), Positives = 133/335 (39%), Gaps = 60/335 (17%)
Query: 250 KRGVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIV 309
KRG+H G L +A G D +KL+ G+D++ D+ G T LH AA G+ +
Sbjct: 213 KRGIH----GMFPLHLAALSGFSDCCRKLLSS-GFDIDTPDDFGRTCLHAAAAGGNLECL 267
Query: 310 ELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIE 369
LL+ GA+ N D F +PL A+AN + + L+ GA ++ +G + +
Sbjct: 268 NLLLNTGADFN--KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLH-YA 324
Query: 370 EESDMD---------NDDRRIVHDMKDMLKRATRKYIKHSHR-------------TLQSS 407
SD D ND + D + A + HR L +
Sbjct: 325 ATSDTDGKCLEYLLRNDANPGIRDKQGY--NAVHYSAAYGHRLCLQLIASETPLDVLMET 382
Query: 408 SMSRHSDDIDKQL------------NHD------DDFYWTDISSKLGKNKLLKASKEGKL 449
S + D D + +H D+ + G+ L A+ +G +
Sbjct: 383 SGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHV 442
Query: 450 AYVGSYLENGGRPDFRCFL-------ESCIYGHDDVVSLFLAFGA---QVNMSNKEGQTP 499
V + G + ++ + GH + + L + V++ + GQTP
Sbjct: 443 ECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTP 502
Query: 500 LMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALH 534
LMLSV GH + V LL GA+ DK +TALH
Sbjct: 503 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALH 537
Score = 66.2 bits (160), Expect = 2e-10
Identities = 71/289 (24%), Positives = 113/289 (38%), Gaps = 52/289 (17%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+D T L A G + K L++ G D+N+ + GNTPLH A NG +V L+
Sbjct: 48 KDKKSYTPLHAAASSGMISVVKYLLDL-GVDMNEPNAYGNTPLHVACYNGQDVVVNELID 106
Query: 315 NGANVNIQSYDMFLDTPLIDASANGH-INVVKYLLDHGADPTMVNAKGLSAIESIEEESD 373
GA VN ++ F TPL A+A+ H ++ L+ +GAD M + G + +
Sbjct: 107 CGAIVNQKNEKGF--TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLH------- 157
Query: 374 MDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISS 433
A S +QS ++ D
Sbjct: 158 ----------------MTALHGRFSRSQTIIQSGAV-------------------IDCED 182
Query: 434 KLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLAFGA 487
K G L A++ G + + + +G R + + G D L+ G
Sbjct: 183 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 242
Query: 488 QVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
++ + G+T L + G++ + LLL GAD K DK ++ LHYA
Sbjct: 243 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 291
Score = 54.7 bits (130), Expect = 7e-07
Identities = 35/107 (32%), Positives = 54/107 (49%), Gaps = 1/107 (0%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D+ G+T L +A + G+ + + L+ ++ QDN+ NT LH A GH L++
Sbjct: 699 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 758
Query: 316 GANVN-IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
+ N I + + L TPL A+ NG VV+ LL GA V+ G
Sbjct: 759 ITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 805
>Hs16159328 [R] KOG0504 FOG: Ankyrin repeat
Length = 683
Score = 72.4 bits (176), Expect = 3e-12
Identities = 86/322 (26%), Positives = 130/322 (39%), Gaps = 58/322 (18%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D GRT L A G + K L++ G D + +D G TPLH AA N H +E LV
Sbjct: 109 DKFGRTCLHAAAAGGNVECIK-LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTT 167
Query: 316 GANVNIQSYDMFLDTPLIDASA-----------NGHIN-----------------VVKYL 347
GANVN D + T L A+A N H N +++L
Sbjct: 168 GANVN--ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFL 225
Query: 348 LDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHS-----HR 402
L + A+P++ + +G ++I ++L T + S
Sbjct: 226 LQNDANPSIRDKEGYNSIHYAAAYGH---------RQCLELLLERTNSGFEESDSGATKS 276
Query: 403 TLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRP 462
L ++ + H ++ L D DI + G+ L A+ +G V + + G
Sbjct: 277 PLHLAAYNGHHQALEVLLQSLVDL---DIRDEKGRTALDLAAFKGHTECVEALINQGASI 333
Query: 463 DFRCFL-------ESCIYGHDDVVSLFLAFG---AQVNMSNKEGQTPLMLSVGRGHVNVV 512
+ + S I GH + L L V++ + +GQTPLML+V GH++ V
Sbjct: 334 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 393
Query: 513 KLLLEAGADPQKTDKRKKTALH 534
LLLE A+ D TALH
Sbjct: 394 SLLLEKEANVDTVDILGCTALH 415
Score = 65.9 bits (159), Expect = 3e-10
Identities = 79/291 (27%), Positives = 120/291 (41%), Gaps = 16/291 (5%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGN-TPLHEAALNGHSAIVELLV 313
RD GRT L +A KG + + LI + G + +DN TPLH + +NGH+ + LL+
Sbjct: 303 RDEKGRTALDLAAFKGHTECVEALINQ-GASIFVKDNVTKRTPLHASVINGHTLCLRLLL 361
Query: 314 RNGANVN-IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSA----IESI 368
N + D TPL+ A A GHI+ V LL+ A+ V+ G +A I +
Sbjct: 362 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTG 421
Query: 369 EEESDMDNDDRRIVHDMKDMLKRATRKY-IKHSHRTLQSSSMSRHSDDIDKQLNHDDDFY 427
EE ++ + KD R Y H T S + + D + +
Sbjct: 422 HEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYT 481
Query: 428 WTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAF-- 485
+ G ++ E K ++ N P C + I H + SL L
Sbjct: 482 PLHWACYNGNENCIEVLLEQKC--FRKFIGNPFTP-LHC---AIINDHGNCASLLLGAID 535
Query: 486 GAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ V+ + +G+TPL + HV ++LLL A D KTAL A
Sbjct: 536 SSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMA 586
Score = 64.7 bits (156), Expect = 7e-10
Identities = 65/256 (25%), Positives = 115/256 (44%), Gaps = 15/256 (5%)
Query: 283 GYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHIN 342
G++++ D G T LH AA G+ ++LL +GA + D TPL A+AN H +
Sbjct: 102 GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA--DFHKKDKCGRTPLHYAAANCHFH 159
Query: 343 VVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRI--VHDMKDMLKRATRKYIKHS 400
++ L+ GA+ + G +A+ SDMD + + HD + L+RA + +K
Sbjct: 160 CIETLVTTGANVNETDDWGRTALH-YAAASDMDRNKTILGNAHDNSEELERA--RELKEK 216
Query: 401 HRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGG 460
TL + + +D + + + + ++ G + L E L S E
Sbjct: 217 EATLCLEFLLQ--NDANPSIRDKEGYNSIHYAAAYGHRQCL----ELLLERTNSGFEESD 270
Query: 461 RPDFRCFLESCIY-GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAG 519
+ L Y GH + + L +++ +++G+T L L+ +GH V+ L+ G
Sbjct: 271 SGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQG 330
Query: 520 ADP-QKTDKRKKTALH 534
A K + K+T LH
Sbjct: 331 ASIFVKDNVTKRTPLH 346
Score = 55.8 bits (133), Expect = 3e-07
Identities = 59/257 (22%), Positives = 101/257 (38%), Gaps = 14/257 (5%)
Query: 289 QDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLL 348
+D G +H AA GH +ELL+ + +S +PL A+ NGH ++ LL
Sbjct: 235 RDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL 294
Query: 349 DHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSS 408
D + + KG +A++ + + + I +K K L +S
Sbjct: 295 QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVKDNVTK-----RTPLHASV 349
Query: 409 MSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFL 468
++ H+ + L D+ D+ G+ L+ A G + V LE D L
Sbjct: 350 INGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDIL 409
Query: 469 ------ESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADP 522
+ GH++ V + L + + G+TPL + RGH + LL+
Sbjct: 410 GCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSE 469
Query: 523 QK---TDKRKKTALHYA 536
+ D + T LH+A
Sbjct: 470 EDCCFKDNQGYTPLHWA 486
>7295892 [M] KOG4177 Ankyrin
Length = 342
Score = 72.0 bits (175), Expect = 4e-12
Identities = 79/291 (27%), Positives = 131/291 (44%), Gaps = 56/291 (19%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+D G T L +A G +L+++ G D N + G TPL AA GH +V++L++
Sbjct: 60 KDEDGTTPLILAAAGGHTYCVMELLDQ-GADPNSRRLTGTTPLFFAAQGGHLDVVKILIK 118
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDM 374
GA+V+ S D TPL A GH+ +V+ LLD GA+ VNA
Sbjct: 119 AGASVDTPSADG--GTPLFVACQGGHVKIVRELLDCGAN---VNA--------------- 158
Query: 375 DNDDRRIVHDMKDMLKRATRKYI--KHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDIS 432
MKD RAT +I ++ HRT+ S + ++ K+++ + I+
Sbjct: 159 ---------HMKD---RATPVFISAQNGHRTVLSLLIQAGAEIDIKRIDGATPLW---IA 203
Query: 433 SKLGKNKLLKASKEGKLAYVGSYLENGGRPD-FRC-----FLESCIYGHDDVVSLFLAFG 486
+++G++ + K L+NG D RC ++ GH V+++ L +
Sbjct: 204 AQMGQDHICKV-----------LLQNGANVDTVRCDGATPLFKAAHKGHAAVITVLLKYR 252
Query: 487 AQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYAN 537
+ G++ L + GH+ V K L+ AG+D + TAL A+
Sbjct: 253 PNLGQL-PNGESALHAAAMFGHMTVCKQLVAAGSDVLLKNHDGLTALQLAH 302
Score = 50.8 bits (120), Expect = 1e-05
Identities = 40/152 (26%), Positives = 74/152 (48%), Gaps = 13/152 (8%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA G+ + K L++ +G +V+ G TPL +AA GH+A++ +L++ N
Sbjct: 196 GATPLWIAAQMGQDHICKVLLQ-NGANVDTVRCDGATPLFKAAHKGHAAVITVLLKYRPN 254
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ ++ L A+ GH+ V K L+ G+D + N GL+A++ ++
Sbjct: 255 LGQLPNG---ESALHAAAMFGHMTVCKQLVAAGSDVLLKNHDGLTALQLAHQQK------ 305
Query: 379 RRIVHDMKDMLKRATRKYIKHSHRTLQSSSMS 410
+ D L+ R + S + + +S +S
Sbjct: 306 ---YTSICDYLQERIRTMVARSAKAMATSGVS 334
>Hs20556512 [T] KOG0507 CASK-interacting adaptor protein (caskin) and related
proteins with ankyrin repeats and SAM domain
Length = 765
Score = 70.9 bits (172), Expect = 9e-12
Identities = 66/242 (27%), Positives = 111/242 (45%), Gaps = 30/242 (12%)
Query: 283 GYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHIN 342
G +VN D+ G TPLH AALNGH +VE+L+RN A N+ D PL A+ G
Sbjct: 143 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVA--DSKGCYPLHLAAWKGDAQ 200
Query: 343 VVKYLLDHGADPTMVNAKGLSAIESIEEESDMD-------NDDRRIVH---------DMK 386
+V+ L+ G T VN + I+ +++ D ND+ +H +K
Sbjct: 201 IVRLLIHQGPSHTRVNEQNALEIKELKKYGPFDPYINAKNNDNETALHCAAQYGHTEVVK 260
Query: 387 DMLKRATRKYIKHS--HRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLK-A 443
+L+ T ++++ L +++ + + LN + +S K+ L A
Sbjct: 261 VLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNL----LSCNTKKHTPLHLA 316
Query: 444 SKEGKLAYVGSYLENGGRPDFRCFL-----ESCIYGHDDVVSLFLAFGAQVNMSNKEGQT 498
++ G A V L+ G +++ + E+ ++G DVV + LA G VN+ + G T
Sbjct: 317 ARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLT 376
Query: 499 PL 500
L
Sbjct: 377 AL 378
Score = 52.8 bits (125), Expect = 3e-06
Identities = 34/110 (30%), Positives = 61/110 (54%), Gaps = 4/110 (3%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L +A G+ ++ K L+ ++ + +TPLH AA NGH A+V++L+ G + N
Sbjct: 278 TPLDLAALYGRLEVVKMLLNAHP-NLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSN 336
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEE 370
Y + + L +A+ G +VV+ LL G D + + GL+A++++ E
Sbjct: 337 ---YQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRE 383
>Hs22064845 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 722
Score = 69.7 bits (169), Expect = 2e-11
Identities = 81/310 (26%), Positives = 123/310 (39%), Gaps = 54/310 (17%)
Query: 257 AGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNG 316
A G T L IA + DL L+ G D N D G PLH AA NG LL+ +G
Sbjct: 369 ASGYTPLLIAAQDQQPDLCALLLAH-GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHG 427
Query: 317 ANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG------------LSA 364
A V+ Q + + TPL A+ N NV + L+ ADP + A+G +S
Sbjct: 428 ACVDAQEREGW--TPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSL 485
Query: 365 IESIEEE-SDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHD 423
++ + + +++D R + + ++R + I+H L+S ++
Sbjct: 486 VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQH---LLKSGAV-------------- 528
Query: 424 DDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFL 483
D + G L A+ GK L G P +++ L
Sbjct: 529 -----PDALDQSGYGPLHTAAARGKYLICKMLLSLQGPP-------------GEIIHLLA 570
Query: 484 AFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGL 543
A + TPL L+ G VV LL+ GADP ++ T LH A S L
Sbjct: 571 ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFL 630
Query: 544 TDPDEVNLLK 553
+ +NLL+
Sbjct: 631 S---VINLLE 637
>Hs14770818 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 567
Score = 69.7 bits (169), Expect = 2e-11
Identities = 70/295 (23%), Positives = 128/295 (42%), Gaps = 30/295 (10%)
Query: 217 KHYNEHKRKSSSIENSSNHKKQKHSAGKKIPKTKRGVHRDAGG---RTKLQIACDKGKYD 273
K + +K + E H+K+KH + ++ V +A L+ ++ +Y
Sbjct: 28 KRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYF 87
Query: 274 LAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLI 333
L K+ D+ ++D G T LH+ ++ IV+LL+ +GANVN + +++ TPL
Sbjct: 88 LKNKVSP----DLCNED--GLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELW--TPLH 139
Query: 334 DASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRAT 393
A+ GHIN+VK L+ +GAD VN+ G + E+E +D + + + + T
Sbjct: 140 AAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAY------QGIT 193
Query: 394 RKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVG 453
++ I + ++ DI + D W D G L A G L
Sbjct: 194 QEKINEMRVAPEQQMIA----DIHCMIAAGQDLDWIDAQ---GATLLHIAGANGYLRAAE 246
Query: 454 SYLENGGRPDFRCF------LESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLML 502
L++G R D + + + +G + L ++ GA ++ + P+ L
Sbjct: 247 LLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDL 301
Score = 52.0 bits (123), Expect = 4e-06
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 6/88 (6%)
Query: 440 LLKASKEGKLAYVGSYLENGGRPDF------RCFLESCIYGHDDVVSLFLAFGAQVNMSN 493
LL+AS V +L+N PD + CI +++V L L+ GA VN +
Sbjct: 72 LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
Query: 494 KEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
E TPL + GH+N+VK+L++ GAD
Sbjct: 132 NELWTPLHAAATCGHINLVKILVQYGAD 159
>HsM11545809 [M] KOG4177 Ankyrin
Length = 416
Score = 68.9 bits (167), Expect = 3e-11
Identities = 51/130 (39%), Positives = 71/130 (54%), Gaps = 8/130 (6%)
Query: 260 RTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANV 319
+T L AC G D+ K L+E+ G +VN DN TPLH A G IVELLV +GA +
Sbjct: 166 KTPLMTACASGNIDVVKFLLEK-GANVNATDNFLWTPLHFACHAGQQDIVELLVESGALI 224
Query: 320 NIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDR 379
+ S + TPL A + ++ VKYLLD GA + N KG SA++ + +D
Sbjct: 225 DAASINN--STPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADY----- 277
Query: 380 RIVHDMKDML 389
RI+ +K+ L
Sbjct: 278 RIIDLIKEKL 287
>Hs21314697 [M] KOG4177 Ankyrin
Length = 776
Score = 68.9 bits (167), Expect = 3e-11
Identities = 51/130 (39%), Positives = 71/130 (54%), Gaps = 8/130 (6%)
Query: 260 RTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANV 319
+T L AC G D+ K L+E+ G +VN DN TPLH A G IVELLV +GA +
Sbjct: 526 KTPLMTACASGNIDVVKFLLEK-GANVNATDNFLWTPLHFACHAGQQDIVELLVESGALI 584
Query: 320 NIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDR 379
+ S + TPL A + ++ VKYLLD GA + N KG SA++ + +D
Sbjct: 585 DAASINN--STPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADY----- 637
Query: 380 RIVHDMKDML 389
RI+ +K+ L
Sbjct: 638 RIIDLIKEKL 647
>CE28044 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 480
Score = 68.9 bits (167), Expect = 3e-11
Identities = 66/264 (25%), Positives = 113/264 (42%), Gaps = 23/264 (8%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L+ C + Y ++L+ D + N ++ G TPLH+ A++ + I+ LL+ GANVN Q
Sbjct: 62 LEATC-RADYAEVERLLN-DNANPNLHNDDGLTPLHQCAIDDNQQIMLLLLERGANVNAQ 119
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIV 382
+ + TPL A+ HIN+VK L+ GA+ VNA+G + + E +D V
Sbjct: 120 DTEQW--TPLHAAACCAHINIVKILIQAGANLLAVNAEGNMPYDICDHEETLD------V 171
Query: 383 HDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLK 442
+ + + T+ YI + + + D ++ H D + G L
Sbjct: 172 IESEMAARGITQSYIDEMRGAPEKAMLD------DMKMLHQQG-RELDARAPDGSTYLHV 224
Query: 443 ASKEGKLAYVGSYLENGGRP-----DF-RCFLESCIYGHDDVVSLFLAFGAQVNMSNKEG 496
AS G L P DF + + + D++ L +G ++ K G
Sbjct: 225 ASANGYYDVAAFLLTCSVSPLIRDNDFWQPVHAAACWAQPDLIELLCQYGGDIHAKTKNG 284
Query: 497 QTPLMLSVGRGHVNVVKLLLEAGA 520
+TP+ L V+ L++ A
Sbjct: 285 ETPMDLCEDMSTKQVISQLVQTEA 308
>CE11616 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 476
Score = 68.9 bits (167), Expect = 3e-11
Identities = 66/264 (25%), Positives = 113/264 (42%), Gaps = 23/264 (8%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L+ C + Y ++L+ D + N ++ G TPLH+ A++ + I+ LL+ GANVN Q
Sbjct: 62 LEATC-RADYAEVERLLN-DNANPNLHNDDGLTPLHQCAIDDNQQIMLLLLERGANVNAQ 119
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIV 382
+ + TPL A+ HIN+VK L+ GA+ VNA+G + + E +D V
Sbjct: 120 DTEQW--TPLHAAACCAHINIVKILIQAGANLLAVNAEGNMPYDICDHEETLD------V 171
Query: 383 HDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLK 442
+ + + T+ YI + + + D ++ H D + G L
Sbjct: 172 IESEMAARGITQSYIDEMRGAPEKAMLD------DMKMLHQQG-RELDARAPDGSTYLHV 224
Query: 443 ASKEGKLAYVGSYLENGGRP-----DF-RCFLESCIYGHDDVVSLFLAFGAQVNMSNKEG 496
AS G L P DF + + + D++ L +G ++ K G
Sbjct: 225 ASANGYYDVAAFLLTCSVSPLIRDNDFWQPVHAAACWAQPDLIELLCQYGGDIHAKTKNG 284
Query: 497 QTPLMLSVGRGHVNVVKLLLEAGA 520
+TP+ L V+ L++ A
Sbjct: 285 ETPMDLCEDMSTKQVISQLVQTEA 308
>SPAC2F7.10 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 642
Score = 68.2 bits (165), Expect = 6e-11
Identities = 38/103 (36%), Positives = 56/103 (53%), Gaps = 1/103 (0%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L +A +G+ D K LI + DVN D G T LH AALN I + L+ +GA+VN
Sbjct: 4 LFLAASQGELDTVKNLISSEKIDVNATDEGGATALHWAALNQQIPICKFLLEHGADVNAI 63
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
D+ P+ A+ G + V YL+ HGADP + + +G + +
Sbjct: 64 GGDL-QAAPIHWAAKRGSVKTVHYLVQHGADPLLKDKQGFNCL 105
>Hs7657265 [R] KOG0508 Ankyrin repeat protein
Length = 627
Score = 68.2 bits (165), Expect = 6e-11
Identities = 59/188 (31%), Positives = 93/188 (49%), Gaps = 18/188 (9%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L A G +++ K L+ G +VN +TPL A +G IV+ LV N AN
Sbjct: 88 GATALWCAAGAGHFEVVKLLVSH-GANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNAN 146
Query: 319 VNIQS-YDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDND 377
++I + YD +T L+ A+ GH +VV+YLL+ ADP G +A+ E +D
Sbjct: 147 ISIANKYD---NTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHID-- 201
Query: 378 DRRIVHDMKDMLK-RATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLG 436
+K+++K RA H L+ ++ S +D ++ L+H D D S++
Sbjct: 202 ------IVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHAD----CDRRSRIE 251
Query: 437 KNKLLKAS 444
+LL AS
Sbjct: 252 ALELLGAS 259
>CE16523 [R] KOG0504 FOG: Ankyrin repeat
Length = 991
Score = 68.2 bits (165), Expect = 6e-11
Identities = 98/381 (25%), Positives = 152/381 (39%), Gaps = 54/381 (14%)
Query: 207 SAIHEDSSPVKHYNEHKRKSSSIENSSNHKKQKHSAGKKIPKTKRGVHRDAGGRTKLQIA 266
+AI + + H N + + +H+A KI DA GR L +A
Sbjct: 551 NAIDKSGATALHLNLSNGSKQEENSETTKLLLEHNADCKI--------EDANGRVALHLA 602
Query: 267 CDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDM 326
G D +LI E V+ DN G TPL AA G V+ L + A ++ + D
Sbjct: 603 AYHG--DPCLQLILEKHPIVDVMDNMGQTPLMLAASQGQLEAVQFLTKT-AKADVDAIDN 659
Query: 327 FLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSA------------IESIEEESDM 374
T L A+ NGH VV++L G+D + G A ++ + + +
Sbjct: 660 NGRTALQWAAINGHPEVVEFLCSVGSDEGHKDNDGAVALHYAVTHDHVELVKHLTNQHTV 719
Query: 375 DNDDRRIVHDMKDMLKRATRKYIK-------------HSHRT-LQSSSMSRHSDDIDKQL 420
+ DR H M K ++ H RT L +SM+ H+ ID
Sbjct: 720 EAKDRYGQHPMMIAAANGNLKVLEYLMGISDIINQPDHEGRTALSLASMAAHTSIIDLIS 779
Query: 421 NHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGS-YLENGGR-PDFRCFLESCIY---GH 475
D+ D + L+ ++ L +V YL +G D +C++
Sbjct: 780 PRITDWSQRDHDGTPLAHTLILSN----LIFVAEVYLGHGANSSDSDAHGRTCVHVVAST 835
Query: 476 DDVVS---LFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEA-GADPQKTDKRKKT 531
+DV + L G ++ G+T LM +V HV + LL++ G DP +TD++ T
Sbjct: 836 NDVAAAKMLKRIGGVNFEAVDRGGRTALMTAVWAKHVAISVFLLDSCGVDPNRTDRQGAT 895
Query: 532 ALHYANHSSLGLTDPDEVNLL 552
AL A + D D VNLL
Sbjct: 896 ALSIAAQ----IGDRDLVNLL 912
Score = 51.6 bits (122), Expect = 6e-06
Identities = 37/111 (33%), Positives = 52/111 (46%), Gaps = 11/111 (9%)
Query: 437 KNKLLKASKEGKLAYVGSYLENGGRPDFR------CFLESCIYGHDDVVSLFLAFGAQVN 490
+ L A+ G+LA V L+ G D R + + H DVVS+ + +GA VN
Sbjct: 492 RTALRAAAWSGQLAAVQLLLQTGAEVDRRDSEQRTALMAAAFMCHKDVVSVIIQYGADVN 551
Query: 491 MSNKEGQTPLMLSVGRG-----HVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+K G T L L++ G + KLLLE AD + D + ALH A
Sbjct: 552 AIDKSGATALHLNLSNGSKQEENSETTKLLLEHNADCKIEDANGRVALHLA 602
>Hs10863929_1 [M] KOG4177 Ankyrin
Length = 361
Score = 68.2 bits (165), Expect = 6e-11
Identities = 75/267 (28%), Positives = 115/267 (42%), Gaps = 34/267 (12%)
Query: 273 DLAKKLIEEDGYDVNDQDNAGN-TPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTP 331
DL ++L+E G +VN Q+ G TPLH A IVELL+R+GA+ ++ + TP
Sbjct: 39 DLVQQLLE-GGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGA--TP 95
Query: 332 LIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKR 391
I A+ G + ++K L GAD + G +A M+ V +K + KR
Sbjct: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAF--------MEAAVYGKVKALKFLYKR 147
Query: 392 AT----RKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEG 447
R+ K L+ + D +K G ++LK +
Sbjct: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEK-----------------GHVEVLKILLDE 190
Query: 448 KLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRG 507
A V + G L S + + L L GA VN+ + G+TPL+L+V +
Sbjct: 191 MGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKK 250
Query: 508 HVNVVKLLLE-AGADPQKTDKRKKTAL 533
H+ +V+ LLE + TD KTAL
Sbjct: 251 HLGLVQRLLEQEHIEINDTDSDGKTAL 277
Score = 56.2 bits (134), Expect = 2e-07
Identities = 48/144 (33%), Positives = 67/144 (46%), Gaps = 11/144 (7%)
Query: 253 VHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELL 312
V R G T +A G L K + + G DVN+ D G T EAA+ G ++ L
Sbjct: 86 VLRKKNGATPFILAAIAGSVKLLKLFLSK-GADVNECDFYGFTAFMEAAVYGKVKALKFL 144
Query: 313 VRNGANVNIQSYDMFLD--------TPLIDASANGHINVVKYLLDH-GADPTMVNAKGLS 363
+ GANVN++ T L+DA+ GH+ V+K LLD GAD + G +
Sbjct: 145 YKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRN 204
Query: 364 AIESIEEESDMDNDDRRIVHDMKD 387
A+ SD D+D I H + D
Sbjct: 205 ALIHALLSSD-DSDVEAITHLLLD 227
Score = 54.7 bits (130), Expect = 7e-07
Identities = 41/107 (38%), Positives = 56/107 (52%), Gaps = 7/107 (6%)
Query: 248 KTKRGVHR-DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGH- 305
KTK R GG T L A +KG ++ K L++E G DVN DN G L A L+
Sbjct: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDD 215
Query: 306 ---SAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLD 349
AI LL+ +GA+VN++ TPLI A H+ +V+ LL+
Sbjct: 216 SDVEAITHLLLDHGADVNVRGERG--KTPLILAVEKKHLGLVQRLLE 260
>Hs22059561 [R] KOG0504 FOG: Ankyrin repeat
Length = 301
Score = 67.8 bits (164), Expect = 8e-11
Identities = 71/266 (26%), Positives = 117/266 (43%), Gaps = 14/266 (5%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
A +G L K L+ DV+ +D+ G T L AA GH V LV GA++N+Q
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVH-- 383
T L A+ GH +VV++L GA G +A+ + + M + + H
Sbjct: 79 G--TTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGA 136
Query: 384 DMKDML-KRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDF-YWTDISSKLGKNKLL 441
++ D L AT ++ L + S Q D W I+S++G ++++
Sbjct: 137 NIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLW--IASQMGHSEVV 194
Query: 442 KASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLM 501
+ + G+ + L++ G++DV+ L F + + K G + L
Sbjct: 195 RV-----MLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALH 248
Query: 502 LSVGRGHVNVVKLLLEAGADPQKTDK 527
+V G++ V LLLEAGADP +K
Sbjct: 249 AAVLSGNIKTVALLLEAGADPSLRNK 274
Score = 60.5 bits (145), Expect = 1e-08
Identities = 64/243 (26%), Positives = 102/243 (41%), Gaps = 41/243 (16%)
Query: 295 TPLHEAAL----NGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDH 350
TPL AA G+ A+++LL+ +G V++ D T L+ A+ GHI+ V+ L+
Sbjct: 10 TPLANAAFWAARRGNLALLKLLLNSG-RVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ 68
Query: 351 GADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMS 410
GAD + G +A+ ++ ND R + +T K L ++S
Sbjct: 69 GADINLQRESGTTALFFAAQQGH--NDVVRFLFGFG----ASTEFRTKDGGTALLAASQY 122
Query: 411 RHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLES 470
H ++ L H + + ++L + LA G YL
Sbjct: 123 GHMQVVETLLKHGANIH----------DQLYDGATALFLAAQGGYL-------------- 158
Query: 471 CIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKK 530
DV+ L LA GA+VN ++G PL ++ GH VV+++L GAD
Sbjct: 159 ------DVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGT 212
Query: 531 TAL 533
TAL
Sbjct: 213 TAL 215
>Hs16076877 [R] KOG0504 FOG: Ankyrin repeat
Length = 1101
Score = 67.8 bits (164), Expect = 8e-11
Identities = 70/268 (26%), Positives = 115/268 (42%), Gaps = 23/268 (8%)
Query: 274 LAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMF-----L 328
L KK + D D N G L AAL GH +V+ L++ + Q +F +
Sbjct: 38 LCKKRAKVDHLDKN-----GQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAI 92
Query: 329 DTPLIDASANGHINVVKYLLD-HGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKD 387
LI A++ G+ +V YLLD D V +++ +S+ E+ + R ++
Sbjct: 93 QQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCR 152
Query: 388 MLKRATRKYIKHSHR---TLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKAS 444
+L + + R L S+ H +D L H D +++ K G+ L+ A+
Sbjct: 153 LLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGAD---VNMADKQGRTPLMMAA 209
Query: 445 KEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQT 498
EG L V L G + +C+ GH VV + GA + ++K G+T
Sbjct: 210 SEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRT 269
Query: 499 PLMLSVGRGHVNVVKLLLEAGADPQKTD 526
PL L+ G VV+ L++ GA + D
Sbjct: 270 PLDLAAFYGDAEVVQFLVDHGAMIEHVD 297
Score = 66.2 bits (160), Expect = 2e-10
Identities = 75/299 (25%), Positives = 125/299 (41%), Gaps = 68/299 (22%)
Query: 278 LIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASA 337
L+ E G +V+ +G TPL AA G+ +IV LL + A V+ D L+ A+
Sbjct: 4 LLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVD--HLDKNGQCALVHAAL 61
Query: 338 NGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKD-MLKRATRKY 396
GH+ VVK+L+ D TM + + + ++S H ++ ++ A+ Y
Sbjct: 62 RGHLEVVKFLIQ--CDWTMAGQQ-----QGVFKKS----------HAIQQALIAAASMGY 104
Query: 397 IKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYL 456
+ L + +++++ + D W G+ L A+ GKL L
Sbjct: 105 TEIVSYLLDLPE--KDEEEVERAQINSFDSLW-------GETALTAAAGRGKLEVCRLLL 155
Query: 457 ENGG---RPDFRC---FLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVG----- 505
E G +P+ R + GH +V L L GA VNM++K+G+TPLM++
Sbjct: 156 EQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLG 215
Query: 506 ----------------------------RGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+GH++VV+ L++ GA DK +T L A
Sbjct: 216 TVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLA 274
Score = 54.3 bits (129), Expect = 9e-07
Identities = 73/297 (24%), Positives = 115/297 (38%), Gaps = 37/297 (12%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQD------NAGNTPLHEAALNGHSA 307
H D G+ L A +G ++ K LI+ D Q +A L AA G++
Sbjct: 47 HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTE 106
Query: 308 IVELLV-------RNGANVNIQSYD-MFLDTPLIDASANGHINVVKYLLDHGADPTMVNA 359
IV L+ I S+D ++ +T L A+ G + V + LL+ GA N
Sbjct: 107 IVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNR 166
Query: 360 KGLSAIESIEEESDMDNDDRRIVH----DMKDMLKRATRKYIKHSHRTLQSSSMSRHSDD 415
+G + S + D + H +M D K L ++ H
Sbjct: 167 RGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD----------KQGRTPLMMAASEGHLGT 216
Query: 416 IDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDF-----RCFLE- 469
+D L D K G L A +G L+ V S ++NG D R L+
Sbjct: 217 VDFLLAQGASIALMD---KEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDL 273
Query: 470 SCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTD 526
+ YG +VV + GA + + G PL +VG + +VV LL+ + + +D
Sbjct: 274 AAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCPNTSVVVTLLKKRSQDRLSD 330
>CE05814 [R] KOG0502 Integral membrane ankyrin-repeat protein Kidins220
(protein kinase D substrate)
Length = 1398
Score = 67.4 bits (163), Expect = 1e-10
Identities = 78/319 (24%), Positives = 132/319 (40%), Gaps = 48/319 (15%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
R+A G + L +A G +AK+L + D +++ DN G + L AA GH IV LL+
Sbjct: 58 RNANGESLLTVAVRSGNTAVAKQLAQLDPDAIDETDNEGWSALLNAAHCGHVDIVRLLID 117
Query: 315 NGA-----------------------------NVNIQSYDMFLDTPLIDASANGHINVVK 345
NGA N + + D F T LI A+ GH+ VV+
Sbjct: 118 NGASVDQPDLMGWSPLMWAVYKNHLDVVDLLVNAKVNACDKFGSTALIWAARKGHLPVVQ 177
Query: 346 YLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYI--KHSHRT 403
LL+ GA+ V+A G+ + ++ M + ++ +L R + ++
Sbjct: 178 LLLNSGAE---VDAVGMYSSTAL-----MLATRGNFIQVVELLLTREPNVNVADQNGLTA 229
Query: 404 LQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLE-----N 458
L ++ ++D + +N + + + G L A + G A V L+ N
Sbjct: 230 LGMAARDGYADICESLINSG---AFVNQCDRFGNWILTSAVRSGNAAIVRMILDKFADIN 286
Query: 459 GGRPDFRCFLESCI-YGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLE 517
+ R L I +D+ + L + + NK+G+TPL+ + HV++ L+
Sbjct: 287 CQDSEKRTPLHLAIDKSFNDIAYILLEKKPNLELKNKDGETPLLRAAKCRHVHLCTYLMS 346
Query: 518 AGADPQKTDKRKKTALHYA 536
GA D ALH A
Sbjct: 347 FGAKLAAVDNCGDNALHLA 365
>7301236 [T] KOG0507 CASK-interacting adaptor protein (caskin) and related
proteins with ankyrin repeats and SAM domain
Length = 863
Score = 67.0 bits (162), Expect = 1e-10
Identities = 74/261 (28%), Positives = 113/261 (42%), Gaps = 44/261 (16%)
Query: 286 VNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVK 345
+N QD G T LH A LNGHS IV LL+ + A +++ D+ TPL A+ GH ++VK
Sbjct: 42 INCQDMNGYTSLHHACLNGHSNIVRLLLSHNALLDVP--DIRGSTPLFLAAWAGHQDIVK 99
Query: 346 YLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQ 405
LL H PT N ++IE E+ + + +H H +
Sbjct: 100 MLLMH--SPTGANPNA----QTIENETPLHSG-------------------AQHGHNAVV 134
Query: 406 SSSMSRHSDDIDKQLNHDDDFYWTDISSKLGK----NKLLKASKEGKLAYVGSYLEN--- 458
+ +S +D + + D++++ G+ LL+ + L Y +N
Sbjct: 135 AILLSYGADPAIRNNSFQTAL---DLAAQFGRLQVVQTLLRVYPDLILPYKRLEDDNEEL 191
Query: 459 -GGRPDFRCFLESCIY-----GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVV 512
G P F +C++ GH VV LA G VN+ G + L + G +VV
Sbjct: 192 LGCMPIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAG-SALHEAALCGKKSVV 250
Query: 513 KLLLEAGADPQKTDKRKKTAL 533
LL+AG TD +TAL
Sbjct: 251 VTLLKAGIYVHATDGNGRTAL 271
Score = 52.8 bits (125), Expect = 3e-06
Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 23/123 (18%)
Query: 435 LGKNK-LLKASKEGKLAYVGSYLENGGR-----------PDFRC--------FLESCIYG 474
+GK++ LL+AS+ G + V LE+ + P C +C+ G
Sbjct: 1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNGYTSLHHACLNG 60
Query: 475 HDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLL---EAGADPQKTDKRKKT 531
H ++V L L+ A +++ + G TPL L+ GH ++VK+LL GA+P +T
Sbjct: 61 HSNIVRLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIENET 120
Query: 532 ALH 534
LH
Sbjct: 121 PLH 123
>Hs17864094 [R] KOG0508 Ankyrin repeat protein
Length = 617
Score = 66.6 bits (161), Expect = 2e-10
Identities = 41/118 (34%), Positives = 65/118 (54%), Gaps = 6/118 (5%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L I+C KG ++A+ L+E+ G DVN + GNT LH+ A +G I+++L+ A
Sbjct: 149 GHTCLMISCYKGHKEIAQYLLEK-GADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK 207
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHG--ADPTMVNAKGLSAIESIEEESDM 374
+ Y M TPL+ AS GH N+V +L H + +NA L ++++ D+
Sbjct: 208 MEKDGYGM---TPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDL 262
Score = 58.2 bits (139), Expect = 6e-08
Identities = 43/133 (32%), Positives = 60/133 (44%), Gaps = 8/133 (6%)
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLES------CIYGHDDVVSLFLAFGAQV 489
G L AS G L V S L +G + S C GH ++V + A +
Sbjct: 83 GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADL 142
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTDPDEV 549
+SN+ G T LM+S +GH + + LLE GAD + + TALH S G D ++
Sbjct: 143 EVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAES--GSLDIMKM 200
Query: 550 NLLKAAVRAKYGY 562
L+ A K GY
Sbjct: 201 LLMYCAKMEKDGY 213
Score = 55.5 bits (132), Expect = 4e-07
Identities = 41/128 (32%), Positives = 61/128 (47%), Gaps = 10/128 (7%)
Query: 242 AGKKIPKTKRGVHRDAGGRTKLQIACDKGKYDLAKKLIE------EDGYDVNDQDNA--G 293
A K + + G T L +A G D+ + L+E E G VN G
Sbjct: 24 ASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEG 83
Query: 294 NTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGAD 353
PL A+ GH +V+ L+ +GA+VN + + TPL A +GH+ +VKYL++H AD
Sbjct: 84 APPLWAASAAGHLKVVQSLLNHGASVN--NTTLTNSTPLRAACFDGHLEIVKYLVEHKAD 141
Query: 354 PTMVNAKG 361
+ N G
Sbjct: 142 LEVSNRHG 149
Score = 52.4 bits (124), Expect = 3e-06
Identities = 44/166 (26%), Positives = 74/166 (44%), Gaps = 14/166 (8%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G L A G + + L+ G VN+ +TPL A +GH IV+ LV + A+
Sbjct: 83 GAPPLWAASAAGHLKVVQSLLNH-GASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKAD 141
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
+ + + T L+ + GH + +YLL+ GAD + KG +A+ E +
Sbjct: 142 LEVSNRHGH--TCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSL---- 195
Query: 379 RRIVHDMKDMLKRATRKYIKHSH--RTLQSSSMSRHSDDIDKQLNH 422
D+ ML K K + L S+S++ H++ +D +H
Sbjct: 196 -----DIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH 236
>At3g02850 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 828
Score = 66.6 bits (161), Expect = 2e-10
Identities = 40/99 (40%), Positives = 57/99 (57%), Gaps = 5/99 (5%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D GR+ L +A +G D+ LI+E DVN +D G+TPL EA NG+ + LLV+
Sbjct: 578 DYDGRSPLHLAASRGYEDITLYLIQES-VDVNIKDKLGSTPLLEAIKNGNDRVAALLVKE 636
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADP 354
GA +NI++ FL T + A G + +K LL +G DP
Sbjct: 637 GATLNIENAGTFLCTVV----AKGDSDFLKRLLSNGIDP 671
>Hs7705831 [R] KOG0504 FOG: Ankyrin repeat
Length = 518
Score = 66.2 bits (160), Expect = 2e-10
Identities = 64/267 (23%), Positives = 111/267 (40%), Gaps = 53/267 (19%)
Query: 265 IACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN---I 321
+A +G + +KL+++ G V+ DN G P+HEAA + +++L+ ++ N +
Sbjct: 16 LAAREGNVKVLRKLLKK-GRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKM 74
Query: 322 QSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRI 381
++++ F L A++ GH +V+ LL+ GADP + + + E +D
Sbjct: 75 KTFEGFCALHL--AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQID------ 126
Query: 382 VHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLL 441
R ++H S SM G N L
Sbjct: 127 ----------VLRLLLQHGANVNGSHSM-------------------------CGWNSLH 151
Query: 442 KASKEGKLAYVGSYLENGG----RPDFRC--FLESCIYGHDDVVSLFLAFGAQVNMSNKE 495
+AS + + L G + DF + YG + +S+ ++ GA VN +
Sbjct: 152 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALD 211
Query: 496 GQTPLMLSVGRGHVNVVKLLLEAGADP 522
TPL ++ GH V+LLL +GADP
Sbjct: 212 KATPLFIAAQEGHTKCVELLLSSGADP 238
Score = 55.1 bits (131), Expect = 5e-07
Identities = 33/80 (41%), Positives = 44/80 (54%), Gaps = 2/80 (2%)
Query: 277 KLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDAS 336
KL+ G + QD+ G TPL AA G + +L+ +GANVN Q+ D TPL A+
Sbjct: 163 KLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDK--ATPLFIAA 220
Query: 337 ANGHINVVKYLLDHGADPTM 356
GH V+ LL GADP +
Sbjct: 221 QEGHTKCVELLLSSGADPDL 240
>Hs14149803 [U] KOG2319 Vacuolar assembly/sorting protein VPS9
Length = 1050
Score = 66.2 bits (160), Expect = 2e-10
Identities = 79/310 (25%), Positives = 127/310 (40%), Gaps = 47/310 (15%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D G T L +AC KG Y L+ QDN GNTPLH A GH V+ LV
Sbjct: 493 DYHGATPLHLACQKG-YQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVY- 550
Query: 316 GANVNIQSYDMFL-----DTPLIDASANGHINVVKYLLDHGADPTMVNAKGL-------- 362
+++S + + DTPL A+ G+ V++ LL +GA + N
Sbjct: 551 ---YDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALN 607
Query: 363 SAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNH 422
S I S+ E + + R+ + + + I T SSMS S + + ++
Sbjct: 608 SKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSAGSRQEETKKDY 667
Query: 423 DDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLE-------------NGGRPDF---RC 466
+ KLL+A +G L V LE + P+F C
Sbjct: 668 RE------------VEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLC 715
Query: 467 FLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTD 526
C + + A G VN+++++G +PL ++ G ++++LLL+ GA+ +
Sbjct: 716 QCPKCAPAQKRLAKV-PASGLGVNVTSQDGSSPLHVAALHGRADLIRLLLKHGANAGARN 774
Query: 527 KRKKTALHYA 536
+ LH A
Sbjct: 775 ADQAVPLHLA 784
Score = 66.2 bits (160), Expect = 2e-10
Identities = 39/118 (33%), Positives = 67/118 (56%), Gaps = 3/118 (2%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
R+A L +AC +G + + K L++ + N +D +GNTPL A GH +V LL++
Sbjct: 773 RNADQAVPLHLACQQGHFQVVKCLLDSNAKP-NKKDLSGNTPLIYACSGGHHELVALLLQ 831
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEES 372
+GA++N + +T L +A H+ VV+ LL HGA ++N + +A++ E+ S
Sbjct: 832 HGASINASNNKG--NTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNS 887
Score = 58.2 bits (139), Expect = 6e-08
Identities = 36/104 (34%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 443 ASKEGKLAYVGSYLENGGRPDFRCF------LESCIYGHDDVVSLFLAFGAQVNMSNKEG 496
A ++G V L++ +P+ + + +C GH ++V+L L GA +N SN +G
Sbjct: 784 ACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKG 843
Query: 497 QTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSS 540
T L +V HV VV+LLL GA Q +KR++TA+ A +S
Sbjct: 844 NTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNS 887
Score = 57.0 bits (136), Expect = 1e-07
Identities = 36/95 (37%), Positives = 51/95 (52%), Gaps = 4/95 (4%)
Query: 267 CDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDM 326
C + LAK G +V QD G++PLH AAL+G + ++ LL+++GAN ++ D
Sbjct: 720 CAPAQKRLAKVPASGLGVNVTSQD--GSSPLHVAALHGRADLIRLLLKHGANAGARNADQ 777
Query: 327 FLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
+ PL A GH VVK LLD A P + G
Sbjct: 778 AV--PLHLACQQGHFQVVKCLLDSNAKPNKKDLSG 810
>7298524_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 611
Score = 65.9 bits (159), Expect = 3e-10
Identities = 62/275 (22%), Positives = 125/275 (44%), Gaps = 21/275 (7%)
Query: 269 KGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFL 328
+G D ++ ++ + V D + G + A+ G+ +V L+ GANVN + D
Sbjct: 3 QGHLDFVRQYLDVNPSQV-DVMSGGKACIQVASHQGYVDLVSYLISKGANVN--AVDKEG 59
Query: 329 DTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDM 388
D+ L A+ ++ LL HGA+ +N+ SA+ ++ H ++++
Sbjct: 60 DSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAH--------KKTPHCVREL 111
Query: 389 LKRATRKYIKHSHR-TLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEG 447
L+ I+ S+ T ++ + + ++ + L + + +T + + G N L A+ +G
Sbjct: 112 LQHNANVNIQDSYGDTALHDAIGKENTEVVELLCNAPNLDFT-VKNNRGFNVLHHAALKG 170
Query: 448 ------KLAYVGSYLENGGRPD-FRCFLESCIYGHDDVVSLFLAFG-AQVNMSNKEGQTP 499
++ + L N + D F + + GH VV + G A++++ N QTP
Sbjct: 171 NVVAARRILLLSRQLVNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTP 230
Query: 500 LMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALH 534
+L+V +GH V++ L+ D D+ A+H
Sbjct: 231 FLLAVSQGHAGVIERLVRLSCDVNAKDEDGDNAMH 265
>Hs14738291 [R] KOG0504 FOG: Ankyrin repeat
Length = 1554
Score = 65.5 bits (158), Expect = 4e-10
Identities = 72/268 (26%), Positives = 112/268 (40%), Gaps = 44/268 (16%)
Query: 278 LIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASA 337
L+ E G ++ G T L AA GH +V LL + G V + D L+ ++
Sbjct: 646 LLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKG--VRVDHLDKKGQCALVHSAL 703
Query: 338 NGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYI 397
GH ++++YLL P L R H ++ L A
Sbjct: 704 RGHGDILQYLLTCEWSPGPPQPGTL-----------------RKSHALQQALTAAA---- 742
Query: 398 KHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLE 457
++ SS+ + ++K+ H+ + TD + G+ L A+ GKL L
Sbjct: 743 -----SMGHSSVVQCLLGMEKE--HEVEVNGTD--TLWGETALTAAAGRGKLEVCELLLG 793
Query: 458 NG---------GRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGH 508
+G G P C GH +V L L G VN+S+K+G+TPLM++ GH
Sbjct: 794 HGAAVSRTNRRGVPPLFCAARQ---GHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 850
Query: 509 VNVVKLLLEAGADPQKTDKRKKTALHYA 536
++ V+ LL GA DK +AL +A
Sbjct: 851 LSTVEFLLSKGAALSSLDKEGLSALSWA 878
Score = 60.8 bits (146), Expect = 9e-09
Identities = 39/107 (36%), Positives = 60/107 (55%), Gaps = 3/107 (2%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L A +GK ++ + L+ G V+ + G PL AA GH IV LL+ G +
Sbjct: 772 GETALTAAAGRGKLEVCELLLGH-GAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCD 830
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
VN+ D TPL+ A+ GH++ V++LL GA + ++ +GLSA+
Sbjct: 831 VNLS--DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 875
Score = 51.2 bits (121), Expect = 8e-06
Identities = 37/108 (34%), Positives = 53/108 (48%), Gaps = 3/108 (2%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G L A +G + + + L+E G DVN D G TPL AA GH + VE L+ GA
Sbjct: 805 GVPPLFCAARQGHWQIVRLLLER-GCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA- 862
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+ S D + L A GH VV+YL++ GA + G + ++
Sbjct: 863 -ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLD 909
>7299952 [R] KOG0508 Ankyrin repeat protein
Length = 662
Score = 65.1 bits (157), Expect = 5e-10
Identities = 45/116 (38%), Positives = 57/116 (48%), Gaps = 20/116 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEE-------------DGYDVNDQDNAGNTPLHEAALNGH 305
G T L I+C G YD+ + L+ + DG + D PL AA GH
Sbjct: 39 GATPLVISCRNGHYDIVEYLLTKCRANVEQVGSVSFDGEPIEDAP-----PLWCAAAAGH 93
Query: 306 SAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
IV++LVR GANVN S TPL A +GH +VKYL+ HGAD + N G
Sbjct: 94 LGIVKMLVRRGANVN--STTRTNSTPLRAACFDGHYEIVKYLVHHGADFEVANRHG 147
Score = 65.1 bits (157), Expect = 5e-10
Identities = 36/90 (40%), Positives = 57/90 (63%), Gaps = 4/90 (4%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IAC KG + +A+ L+ + DVN GNT LH+ A +G I++LL+++GA
Sbjct: 147 GHTCLMIACYKGHFRIAQYLLSLNA-DVNRCSVKGNTALHDCAESGSLQILQLLLKHGAT 205
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLL 348
+++ Y M TPL+ AS GH+ +V++L+
Sbjct: 206 MDVDYYGM---TPLLAASVTGHMPIVEHLI 232
Score = 52.0 bits (123), Expect = 4e-06
Identities = 34/112 (30%), Positives = 51/112 (45%), Gaps = 3/112 (2%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L A G + K L+ G +VN +TPL A +GH IV+ LV +GA+ +
Sbjct: 85 LWCAAAAGHLGIVKMLVRR-GANVNSTTRTNSTPLRAACFDGHYEIVKYLVHHGADFEVA 143
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDM 374
+ T L+ A GH + +YLL AD + KG +A+ E +
Sbjct: 144 NRHGH--TCLMIACYKGHFRIAQYLLSLNADVNRCSVKGNTALHDCAESGSL 193
>Hs19718743 [T] KOG2209 Oxysterol-binding protein
Length = 927
Score = 64.7 bits (156), Expect = 7e-10
Identities = 66/253 (26%), Positives = 99/253 (39%), Gaps = 75/253 (29%)
Query: 289 QDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLL 348
+ N G TPLH A GH +V+ L++ GA VN+ + DM DTPL A+ G +V LL
Sbjct: 44 KSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLN-DMG-DTPLHRAAFTGRKELVMLLL 101
Query: 349 DHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSS 408
++ AD T+VN G +A E E +++ ML+ R +
Sbjct: 102 EYNADTTIVNGSGQTAKEVTHAE------------EIRSMLEAVER-------------T 136
Query: 409 MSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFL 468
R +++ LL A++EGK + + L PD
Sbjct: 137 QQRKLEEL-----------------------LLAAAREGKTTELTALLNRPNPPD----- 168
Query: 469 ESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKR 528
VN S++ G TPL + R H LL +GADP +K
Sbjct: 169 --------------------VNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKN 208
Query: 529 KKTALHYANHSSL 541
+ L A + +
Sbjct: 209 DQKPLDLAQGAEM 221
>Hs19718741 [T] KOG2209 Oxysterol-binding protein
Length = 950
Score = 64.7 bits (156), Expect = 7e-10
Identities = 66/253 (26%), Positives = 99/253 (39%), Gaps = 75/253 (29%)
Query: 289 QDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLL 348
+ N G TPLH A GH +V+ L++ GA VN+ + DM DTPL A+ G +V LL
Sbjct: 44 KSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLN-DMG-DTPLHRAAFTGRKELVMLLL 101
Query: 349 DHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSS 408
++ AD T+VN G +A E E +++ ML+ R +
Sbjct: 102 EYNADTTIVNGSGQTAKEVTHAE------------EIRSMLEAVER-------------T 136
Query: 409 MSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFL 468
R +++ LL A++EGK + + L PD
Sbjct: 137 QQRKLEEL-----------------------LLAAAREGKTTELTALLNRPNPPD----- 168
Query: 469 ESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKR 528
VN S++ G TPL + R H LL +GADP +K
Sbjct: 169 --------------------VNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKN 208
Query: 529 KKTALHYANHSSL 541
+ L A + +
Sbjct: 209 DQKPLDLAQGAEM 221
>Hs14764060 [R] KOG0508 Ankyrin repeat protein
Length = 669
Score = 64.7 bits (156), Expect = 7e-10
Identities = 37/90 (41%), Positives = 54/90 (59%), Gaps = 4/90 (4%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L I+C KG ++A+ L+E+ G VN + GNT LH+ A +G I++LL+ A
Sbjct: 150 GHTCLMISCYKGHREIARYLLEQ-GAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKAR 208
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLL 348
+ Y M TPL+ AS GH N+V+YL+
Sbjct: 209 MERDGYGM---TPLLAASVTGHTNIVEYLI 235
>At2g25600 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 888
Score = 64.3 bits (155), Expect = 9e-10
Identities = 45/127 (35%), Positives = 58/127 (45%), Gaps = 30/127 (23%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D GRT L IA KG + L+E G D N +D+ GN PL EA + H I +LL N
Sbjct: 574 DKDGRTALHIAASKGSHYCVVLLLEH-GADPNIRDSEGNVPLWEAIIGRHREIAKLLAEN 632
Query: 316 GANVNIQSYDMF---------LD--------------------TPLIDASANGHINVVKY 346
GA +++ S F LD T L A + GH+ +VK+
Sbjct: 633 GAKLSLDSVSYFSGLAVEKNCLDALKDIIKYGGDVTLPDGNGTTALHRAVSEGHLEIVKF 692
Query: 347 LLDHGAD 353
LLD GAD
Sbjct: 693 LLDQGAD 699
>YDR264c [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 764
Score = 63.9 bits (154), Expect = 1e-09
Identities = 36/107 (33%), Positives = 62/107 (57%), Gaps = 3/107 (2%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGN--TPLHEAALNGHSAIVELLVRNGAN 318
T+ AC +G K++I +VN+ ++ T LH A++N ++V+ LV GA+
Sbjct: 75 TRYHTACQRGDLATVKEMIHGKLLEVNNDGDSTEHITGLHWASINNRLSVVDFLVSQGAD 134
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
VN ++ + TPL A+ G++ +V +LL HGADPTM + +G + +
Sbjct: 135 VNARAGALHA-TPLHWAARYGYVYIVDFLLKHGADPTMTDDQGFNLL 180
>At5g13300 [T] KOG0521 Putative GTPase activating proteins (GAPs)
Length = 750
Score = 63.9 bits (154), Expect = 1e-09
Identities = 44/123 (35%), Positives = 61/123 (48%), Gaps = 9/123 (7%)
Query: 430 DISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQV 489
D+ +L L + ++ GS GG C E G +V L L +GA V
Sbjct: 626 DVLLRLRNELLDRTGSSSNISPEGS----GGSSLLHCACEKADLG---MVELLLQYGANV 678
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGLTDPDEV 549
N S+ GQTPL + RG V + +LLL GADP+ ++ KTAL A S+ TDP+ +
Sbjct: 679 NASDSSGQTPLHCCLLRGKVTIARLLLTRGADPEAMNREGKTALDIAAESN--FTDPEVL 736
Query: 550 NLL 552
LL
Sbjct: 737 ALL 739
Score = 51.2 bits (121), Expect = 8e-06
Identities = 33/113 (29%), Positives = 58/113 (51%), Gaps = 4/113 (3%)
Query: 274 LAKKLIEEDGY--DVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTP 331
L +L++ G +++ + + G++ LH A +VELL++ GANVN D TP
Sbjct: 631 LRNELLDRTGSSSNISPEGSGGSSLLHCACEKADLGMVELLLQYGANVNAS--DSSGQTP 688
Query: 332 LIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHD 384
L G + + + LL GADP +N +G +A++ E + D + ++ D
Sbjct: 689 LHCCLLRGKVTIARLLLTRGADPEAMNREGKTALDIAAESNFTDPEVLALLSD 741
>Hs22060186 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 632
Score = 63.5 bits (153), Expect = 1e-09
Identities = 70/281 (24%), Positives = 116/281 (40%), Gaps = 62/281 (22%)
Query: 251 RGVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVE 310
R H D + A G Y+ ++L+E GYDV D T LH AA+N +V+
Sbjct: 49 RKTHIDDYSTWDIVKATQYGIYERCRELVEA-GYDVRQPDKENVTLLHWAAINNRIDLVK 107
Query: 311 LLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE---- 366
+ GA V+ D+ TPL A+ GH+++V L+ +GADP++++ +G S I
Sbjct: 108 YYISKGAIVDQLGGDLN-STPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQ 166
Query: 367 ---------SIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDID 417
I + D+D D+ + M ++ A R + R L + ++S
Sbjct: 167 FGHTSIVAYLIAKGQDVDMMDQ---NGMTPLMWAAYRTHSVDPTRLLLTFNVS------- 216
Query: 418 KQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDD 477
++ K KN L + + G+
Sbjct: 217 -----------VNLGDKYHKNTALH--------------------------WAVLAGNTT 239
Query: 478 VVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEA 518
V+SL L GA V+ N +G++ L L+ R +V ++ L EA
Sbjct: 240 VISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEA 280
>Hs14150037 [R] KOG0504 FOG: Ankyrin repeat
Length = 422
Score = 63.5 bits (153), Expect = 1e-09
Identities = 45/146 (30%), Positives = 76/146 (51%), Gaps = 7/146 (4%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L AC + + L+ G D+N +DNAG TPLHEA G++ V+ +++
Sbjct: 171 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 230
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMV---NAKGLSAIESIEEESDMD 375
V++ + + TPL DA +NGH+ + K LL HG P ++ NAKG ++ + S
Sbjct: 231 VDLLT-QVDGVTPLHDALSNGHVEIGKLLLQHGG-PVLLQQRNAKGELPLDYV--VSPQI 286
Query: 376 NDDRRIVHDMKDMLKRATRKYIKHSH 401
++ + ++D ++ + KH H
Sbjct: 287 KEELFAITKIEDTVENFHAQAEKHFH 312
>At2g31820 [R] KOG0504 FOG: Ankyrin repeat
Length = 662
Score = 63.5 bits (153), Expect = 1e-09
Identities = 80/326 (24%), Positives = 134/326 (40%), Gaps = 34/326 (10%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVND----QDNAGNTPLHEAALNGHSAIVELLVR 314
G + L IA G K+LI G ++ + Q+ G TPL+ AA NGHS +VE +++
Sbjct: 151 GDSSLHIAARTGNLSKVKELIRGCGDELKELLSKQNLEGETPLYTAAENGHSIVVEEMLK 210
Query: 315 NG--ANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEES 372
+ +I + + F P A+ GH+ V+K LL+ P + LS ++ +
Sbjct: 211 HMDLETASIAARNGF--DPFHVAAKQGHLEVLKILLE--TFPNLAMTTDLSCTTALHTAA 266
Query: 373 DMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDF-YWTDI 431
+ D +V+ + + + + L S++ H + + + D + TD
Sbjct: 267 TQGHID--VVNLLLETDSNLAKIAKNNGKTALHSAARMGHVEVVKSLIGKDPSIGFRTDK 324
Query: 432 SSKLGKNKLLKASKEGKLAY-------VGSYLENGGRPDFRCFLESCIYGHDDVVSLFLA 484
+ + +K +G + V S +N G G +V ++
Sbjct: 325 KGQTALHMAVKGQNDGIVVELVKPDVAVLSVEDNKGNTPLHIATNK---GRIKIVRCLVS 381
Query: 485 F-GAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGA-------DPQKTDKRKKTALHYA 536
F G +N NK G TPL +S G+ +V +L EAGA PQ K+ K +
Sbjct: 382 FEGINLNPINKAGDTPLDVSEKIGNAELVSVLKEAGAATAKDLGKPQNPAKQLKQTVSDI 441
Query: 537 NH---SSLGLTDPDEVNLLKAAVRAK 559
H S L + V + K A R K
Sbjct: 442 KHEVQSQLQQSRQTGVRVQKIAKRLK 467
>Hs18252778 [R] KOG0504 FOG: Ankyrin repeat
Length = 587
Score = 63.2 bits (152), Expect = 2e-09
Identities = 64/259 (24%), Positives = 115/259 (43%), Gaps = 21/259 (8%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
A G + K +I+E G ++ + + G PLHEAA G +++L R I
Sbjct: 64 AIKDGDEEALKTMIKE-GKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGT-IDQRT 121
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDM 385
+ +T + A+ GH++ + LL GA+P + N + + E + + + H+
Sbjct: 122 LQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNA 181
Query: 386 KDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSK--LGKNKLLKA 443
D R R + T S+SR+ ++ + L + SK G L A
Sbjct: 182 -DTNHRCNRGW------TALHESVSRNDLEVMQILVSGG----AKVESKNAYGITPLFVA 230
Query: 444 SKEGKL------AYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQ 497
++ G+L A G+ + + E+C H++VV L+ GA N +NK+G
Sbjct: 231 AQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGL 290
Query: 498 TPLMLSVGRGHVNVVKLLL 516
PL ++ +G+ +V++LL
Sbjct: 291 LPLHIASKKGNYRIVQMLL 309
Score = 55.5 bits (132), Expect = 4e-07
Identities = 65/268 (24%), Positives = 120/268 (44%), Gaps = 34/268 (12%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
HR G T L + + ++ + L+ G V ++ G TPL AA +G + L
Sbjct: 185 HRCNRGWTALHESVSRNDLEVMQILVS-GGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESD 373
+ GA++N Q+ D + L +A N H VV++LL GAD N GL + ++ +
Sbjct: 244 KYGADINTQASDNA--SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGN 301
Query: 374 MDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISS 433
RIV + +L +R I+ S + + R+ D++ + L +S+
Sbjct: 302 Y-----RIV---QMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEAL----------LSA 343
Query: 434 KLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSN 493
+ N L A + +L Y + + + + +Y + L L GA N
Sbjct: 344 RFDVNTPL-APERARL-----YEDRRSSALYFAVVNNNVYATE----LLLQHGAD---PN 390
Query: 494 KEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
++ +PL++++ G + ++LLL+ GA+
Sbjct: 391 RDVISPLLVAIRHGCLRTMQLLLDHGAN 418
>At2g26650 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 857
Score = 63.2 bits (152), Expect = 2e-09
Identities = 41/129 (31%), Positives = 67/129 (51%), Gaps = 8/129 (6%)
Query: 250 KRGV---HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
KRG+ D GRT L IA KG + L+E D N +D G+ PL EA + GH
Sbjct: 539 KRGLDPNESDNNGRTPLHIAASKGTLNCVLLLLEYHA-DPNCRDAEGSVPLWEAMVEGHE 597
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+V++L+ +G+ ++ F T A+ G++ ++K ++ HG D T A G SA+
Sbjct: 598 KVVKVLLEHGSTIDAGDVGHFACT----AAEQGNLKLLKEIVLHGGDVTRPRATGTSALH 653
Query: 367 SIEEESDMD 375
+ E +++
Sbjct: 654 TAVCEENIE 662
Score = 52.0 bits (123), Expect = 4e-06
Identities = 47/176 (26%), Positives = 76/176 (42%), Gaps = 6/176 (3%)
Query: 273 DLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPL 332
DL + + G D N+ DN G TPLH AA G V LL+ A+ N + D PL
Sbjct: 531 DLLLHQLLKRGLDPNESDNNGRTPLHIAASKGTLNCVLLLLEYHADPNCR--DAEGSVPL 588
Query: 333 IDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRA 392
+A GH VVK LL+HG+ + + + E+ ++ ++H RA
Sbjct: 589 WEAMVEGHEKVVKVLLEHGSTIDAGDVGHFAC--TAAEQGNLKLLKEIVLHGGDVTRPRA 646
Query: 393 TRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWT--DISSKLGKNKLLKASKE 446
T H+ ++ M ++ + +N D WT D++ + G + +E
Sbjct: 647 TGTSALHTAVCEENIEMVKYLLEQGADVNKQDMHGWTPRDLAEQQGHEDIKALFRE 702
>Hs9506623 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 481
Score = 62.4 bits (150), Expect = 3e-09
Identities = 38/100 (38%), Positives = 55/100 (55%), Gaps = 2/100 (2%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
A G ++ K+L+E GYDV D + LH AA+N +V + GA V+ D
Sbjct: 56 ATQYGIFERCKELVEA-GYDVRQPDKENVSLLHWAAINNRLDLVRFYISKGAVVDQLGGD 114
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
+ TPL A GH+ +V LL HGADPT+++ +G S+I
Sbjct: 115 LN-STPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSI 153
>Hs21314722 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1267
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/227 (26%), Positives = 103/227 (44%), Gaps = 18/227 (7%)
Query: 282 DGYDVNDQDNAGN--TPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANG 339
DG D N + N +PLH AA GH I +LV+ GAN++ S D TPL++A+ N
Sbjct: 729 DGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQ--RTPLMEAAENN 786
Query: 340 HINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKY--- 396
H+ VKYL+ GA +A+G + + ++ + + + D+ + +
Sbjct: 787 HLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPM 846
Query: 397 ---IKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVG 453
++ H L +S+ SD + + +W S + ++L A+K +
Sbjct: 847 IWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAK----CDLH 902
Query: 454 SYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPL 500
+ +G P E+ D V LFL+ + V + NKEG+TPL
Sbjct: 903 AVNIHGDSPLHIAAREN----RYDCVVLFLSRDSDVTLKNKEGETPL 945
Score = 56.6 bits (135), Expect = 2e-07
Identities = 39/121 (32%), Positives = 63/121 (51%), Gaps = 2/121 (1%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+DA G T L +A KG Y++ + L+ DVN QD+ G TP+ A H +V+LL+
Sbjct: 804 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 863
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDM 374
G+++NI+ D + L A+ +G +++ + LL D VN G S + E+
Sbjct: 864 KGSDINIR--DNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRY 921
Query: 375 D 375
D
Sbjct: 922 D 922
>Hs17449525 [K] KOG4214 Myotrophin and similar proteins
Length = 118
Score = 62.4 bits (150), Expect = 3e-09
Identities = 40/107 (37%), Positives = 55/107 (51%), Gaps = 3/107 (2%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
A G D K + + G DVN G PLH AA G I+E L+ GA++N D
Sbjct: 9 ALKNGDLDEVKDYVAK-GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAP--D 65
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEES 372
TPL+ A GH++ VK LL GAD T+ GL+A E+ + ++
Sbjct: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQA 112
>7293339 [R] KOG0504 FOG: Ankyrin repeat
Length = 1409
Score = 62.4 bits (150), Expect = 3e-09
Identities = 42/169 (24%), Positives = 74/169 (42%), Gaps = 12/169 (7%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
R G + A G D K ++++ G D N +D G TPLH AA GH ++V L+
Sbjct: 81 RARDGMAPIHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLN 140
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI------ESI 368
+GA +++ Y +P+ DA+ N + + L+ HG T V+ G S+ + +
Sbjct: 141 HGAKLSLDKYG---KSPINDAAENQQVECLNVLVQHG---TSVDYNGKSSSQRHKSQQQL 194
Query: 369 EEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDID 417
++ ++ H + T++S S S S D++
Sbjct: 195 HQQHQQQQQQQQQQHLSSSCNSNSNSSKQTSRSNTIKSKSSSTLSSDVE 243
>Hs4758606 [T] KOG0195 Integrin-linked kinase
Length = 452
Score = 62.0 bits (149), Expect = 4e-09
Identities = 34/95 (35%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 267 CDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDM 326
C +G + ++ D+N D+ G +PLH A G SA+VE+L+ GA +N+ +
Sbjct: 8 CREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGD 67
Query: 327 FLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
DTPL A+++GH ++V+ LL + AD VN G
Sbjct: 68 --DTPLHLAASHGHRDIVQKLLQYKADINAVNEHG 100
>7298956 [R] KOG0510 Ankyrin repeat protein
Length = 914
Score = 62.0 bits (149), Expect = 4e-09
Identities = 56/203 (27%), Positives = 89/203 (43%), Gaps = 35/203 (17%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSA--IVELLVRNG 316
G T L +A D + L+ D N +D TPLH A +A I+E L++ G
Sbjct: 282 GFTPLHLAARTSSLDCVESLLRNGNADANAEDFDHRTPLHAAVGKSENAYDIMETLIQWG 341
Query: 317 ANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDN 376
ANVN + D++ T L A+ +G + V+ L+ HGAD T + KG SA+ I
Sbjct: 342 ANVNHK--DIYGFTALHLAALDGLVQCVEMLIFHGADVTTKSKKGTSALNVI-------- 391
Query: 377 DDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLG 436
TRK T S +M R D L+H D ++ +L
Sbjct: 392 ----------------TRK-------TPASVAMIRQKLDAAITLHHSQDPVNREVELELD 428
Query: 437 KNKLLKASKEGKLAYVGSYLENG 459
+LL+ +++Y+ ++++ G
Sbjct: 429 FRQLLQHCHPREISYLNTFVDEG 451
>7294194 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 1023
Score = 62.0 bits (149), Expect = 4e-09
Identities = 43/150 (28%), Positives = 78/150 (51%), Gaps = 12/150 (8%)
Query: 223 KRKSSSIENSSNHKKQKHSAGKKIPKTKRGVHRDAGGRTKLQ------IACDKGKYDLAK 276
+ S+ ++ + K+ + S + T R H G R K AC G D
Sbjct: 7 RNNSAMMKRAEQLKRWEESDTNRAAPTPRHEH---GRRIKFSSGCVFLAACLSGDKDEVV 63
Query: 277 KLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDAS 336
+L+++ G D+N + G T LH+A ++ + +VE LV GA++N Q + + TPL +
Sbjct: 64 QLLDQ-GADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGW--TPLHATA 120
Query: 337 ANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+ G +++ +YL+++GAD VN+ G A++
Sbjct: 121 SCGFVSIARYLVENGADVAAVNSDGDLALD 150
>Hs20543919 [R] KOG0504 FOG: Ankyrin repeat
Length = 339
Score = 61.6 bits (148), Expect = 6e-09
Identities = 44/114 (38%), Positives = 65/114 (56%), Gaps = 5/114 (4%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDN-AGNTPLHE-AALNGHSAIVELL 312
RD GG T L A D G + + +I+ DG +V+ D +G TPL +A++G+ + LL
Sbjct: 200 RDLGGCTALHWAADGGHCSVIEWMIK-DGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLL 258
Query: 313 VRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+ GANVN++ D TPL+ A N H +V+ LLD GAD ++ N G +E
Sbjct: 259 IDAGANVNVK--DRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLE 310
>CE28922 [K] KOG0512 Fetal globin-inducing factor (contains ankyrin repeats)
Length = 231
Score = 61.6 bits (148), Expect = 6e-09
Identities = 37/100 (37%), Positives = 58/100 (58%), Gaps = 2/100 (2%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
A + G+ +L K L+EE +N +D G T LH A+ N HS IV+ L+ +GAN ++ +
Sbjct: 73 AAEDGELELVKVLLEETPNLLNSRDADGYTALHRASYNNHSPIVDHLLLSGANKESKTNE 132
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
+ TPL+ AS + VV LL HG+D ++ L+A+
Sbjct: 133 GW--TPLLSASNWANFEVVGRLLSHGSDVNALSNGNLTAL 170
>7293882 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 762
Score = 61.6 bits (148), Expect = 6e-09
Identities = 58/242 (23%), Positives = 105/242 (42%), Gaps = 48/242 (19%)
Query: 293 GNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGA 352
G T +H+A ++ + +++LL+ GANV+ Q D + TPL A+ GH+ +V+ L+ HGA
Sbjct: 152 GLTAMHQACIDNNVEMLQLLLEYGANVDAQDSDKW--TPLHAAATCGHLELVRILIRHGA 209
Query: 353 DPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRH 412
+ VN G + ++E +D + +M +R + +
Sbjct: 210 NLLAVNTDGNMPYDLCDDEKTLDFIE-------GEMAQRGVTQEL--------------- 247
Query: 413 SDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE--- 469
ID+ + + D+ +LA G LE PD++C
Sbjct: 248 ---IDETRSSTERIMLRDLM---------------ELARTGGDLE---EPDYQCATPLHI 286
Query: 470 SCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRK 529
+ G+ VV L V+ +K+ TP+ + GH+ V+++L + GAD +K
Sbjct: 287 AAANGYVRVVEFLLEQHVNVDAMDKDLWTPVHAAACWGHLEVLEMLAQCGADLNVRNKDD 346
Query: 530 KT 531
+T
Sbjct: 347 ET 348
Score = 55.1 bits (131), Expect = 5e-07
Identities = 40/139 (28%), Positives = 67/139 (47%), Gaps = 7/139 (5%)
Query: 283 GYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHIN 342
G D+ + D TPLH AA NG+ +VE L+ +VN+ + D L TP+ A+ GH+
Sbjct: 270 GGDLEEPDYQCATPLHIAAANGYVRVVEFLLEQ--HVNVDAMDKDLWTPVHAAACWGHLE 327
Query: 343 VVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHR 402
V++ L GAD + N + + E+ + ++ L A R+ ++ S
Sbjct: 328 VLEMLAQCGADLNVRNKDDETPSDICEDPEIRERIEQLKTEQESKRLAEAQRRRVRRS-- 385
Query: 403 TLQSSSMSRHSDDIDKQLN 421
S+ +RH +I + LN
Sbjct: 386 ---QSNNTRHLHNIYEPLN 401
>Hs18561834 [M] KOG4177 Ankyrin
Length = 568
Score = 61.2 bits (147), Expect = 7e-09
Identities = 73/355 (20%), Positives = 149/355 (41%), Gaps = 33/355 (9%)
Query: 203 KISSSAIHEDSSPVKHYNEHKRKSSSIENSSNHKKQKHSAGKKIPKTKRGVHRDAGGRTK 262
K++ + ++ + H+ + S+++ HK + A K G T
Sbjct: 91 KVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKH-------------GLTV 137
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
+ +A G ++ L++ G D ++ G + LH A + H IVE L+++ ++
Sbjct: 138 IHLAAWSGSLEVMLMLVKA-GADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLN 196
Query: 323 SYDMFLDTPLIDASANGHINVVK---YLLDHGADPTMVNAKGLSAIESIEEESDMDNDDR 379
D P + A+ GH+ +++ +L H ++ + L + ++ ++
Sbjct: 197 QPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAA 256
Query: 380 RIVHDMKDM---LKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDIS--SK 434
+ + ++ ++ + L ++ HS + L W DI+ ++
Sbjct: 257 LTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQ-----WQDINEMNE 311
Query: 435 LGKNKLLKASKEGKLAYVGSYLENGG------RPDFRCFLESCIYGHDDVVSLFLAFGAQ 488
L + L A++ G + V L P I H VV+ L+
Sbjct: 312 LNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHD 371
Query: 489 VNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYANHSSLGL 543
+++ N++ QTPL ++ RG+V +V+ LL+AG D + DK+ KTAL A+ S+ L
Sbjct: 372 IDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSL 426
Score = 58.2 bits (139), Expect = 6e-08
Identities = 63/289 (21%), Positives = 119/289 (40%), Gaps = 28/289 (9%)
Query: 264 QIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQS 323
Q A DL +KL E+ ++N +N T LH A H + V+ L+++ A V++
Sbjct: 73 QNAAKSNNLDLMEKLFEKK-VNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA- 130
Query: 324 YDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVH 383
D T + A+ +G + V+ L+ GAD N G+SA+ + N R + +
Sbjct: 131 -DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQS----NHVRIVEY 185
Query: 384 DMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDK------QLNHDDDFYWTDI------ 431
++D+ + + + + ++ H + I+K + D W+ +
Sbjct: 186 LIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT 245
Query: 432 SSKLGKNKLLKASKEGK------LAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAF 485
K +N + + EG ++ L GG + +GH V + LA
Sbjct: 246 KMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAK---HGHSPAVQVLLAQ 302
Query: 486 GAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALH 534
+N N+ + L ++ GH ++V LL D + + K++ LH
Sbjct: 303 WQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLH 351
>Hs18079216 [T] KOG0507 CASK-interacting adaptor protein (caskin) and related
proteins with ankyrin repeats and SAM domain
Length = 1431
Score = 61.2 bits (147), Expect = 7e-09
Identities = 51/185 (27%), Positives = 88/185 (47%), Gaps = 21/185 (11%)
Query: 256 DAGGRTKLQIACDKGKY---------DLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
D G+T L +AC+ G+ ++ L+E D D + G +PLH AA NGH
Sbjct: 145 DNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPN--GTSPLHLAAKNGHI 202
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
I+ LL++ G ++N Q+ T L +A+ G VV+ LLD G + + N +A++
Sbjct: 203 DIIRLLLQAGIDINRQTKS---GTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALD 259
Query: 367 SIEE--ESDMDNDDRRIVHDMKDMLK-RATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHD 423
+ + S + ++++ + L+ RAT+ Y + T S++ + DI L
Sbjct: 260 IVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLT----SLNVKAGDIITVLEQH 315
Query: 424 DDFYW 428
D W
Sbjct: 316 PDGRW 320
Score = 55.1 bits (131), Expect = 5e-07
Identities = 37/112 (33%), Positives = 61/112 (54%), Gaps = 3/112 (2%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+D G + L A G +L L+E V+ +DN G PLH AA G ++L+++
Sbjct: 45 QDPDGFSALHHAALNGNTELISLLLEAQAA-VDIKDNKGMRPLHYAAWQGRKEPMKLVLK 103
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
G+ VNI S + + PL A+ +GH +V + LL H ++P MV+ G + ++
Sbjct: 104 AGSAVNIPSDEGHI--PLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLD 153
>At5g37500 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 735
Score = 61.2 bits (147), Expect = 7e-09
Identities = 38/99 (38%), Positives = 55/99 (55%), Gaps = 5/99 (5%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D GR+ L +A +G D+ LI+E G DVN +D G+TPL EA G ++ LLV+
Sbjct: 476 DYDGRSPLHLAACRGYEDITLFLIQE-GVDVNLKDKFGHTPLFEAVKAGQEGVIGLLVKE 534
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADP 354
GA+ N++ FL T + A G + +K LL G +P
Sbjct: 535 GASFNLEDSGNFLCTTV----AKGDSDFLKRLLSSGMNP 569
>At4g35450 [R] KOG0504 FOG: Ankyrin repeat
Length = 342
Score = 61.2 bits (147), Expect = 7e-09
Identities = 40/92 (43%), Positives = 49/92 (52%), Gaps = 3/92 (3%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D+ GRT L AC G+ A+ LI+ G VN D NTPLH AA G V LL+ N
Sbjct: 248 DSEGRTALHFACGYGELKCAQVLIDA-GASVNAVDKNKNTPLHYAAGYGRKECVSLLLEN 306
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYL 347
GA V +Q+ D TP+ A N + VVK L
Sbjct: 307 GAAVTLQNLDE--KTPIDVAKLNSQLEVVKLL 336
>Hs22047757 [M] KOG4177 Ankyrin
Length = 521
Score = 60.8 bits (146), Expect = 9e-09
Identities = 43/123 (34%), Positives = 66/123 (52%), Gaps = 6/123 (4%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G L K L++ DVN + G +PLH+AA GH+ IV LL++NGA+
Sbjct: 2 GYTPLHVASHYGNIKLVKFLLQHQA-DVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS 60
Query: 319 VNIQSYDMFLDTPLIDASANGHI---NVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
N S D TPL A G+I +V+K + D + + + +S E+++E D+
Sbjct: 61 PNEVSSDG--TTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVS 118
Query: 376 NDD 378
D+
Sbjct: 119 EDE 121
>Hs18593188 [R] KOG0508 Ankyrin repeat protein
Length = 1172
Score = 60.5 bits (145), Expect = 1e-08
Identities = 36/90 (40%), Positives = 52/90 (57%), Gaps = 4/90 (4%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G L I+C KG ++A+ L+E+ G VN + GNT LH A I++LL+ A+
Sbjct: 654 GHMCLMISCYKGHREIARYLLEQ-GAQVNWRSAKGNTALHNCAETSSLEILQLLLGCKAS 712
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLL 348
+ SY M TPL+ AS GH N+V+YL+
Sbjct: 713 MERDSYGM---TPLLPASVTGHTNIVEYLI 739
>At3g12360 [R] KOG0504 FOG: Ankyrin repeat
Length = 590
Score = 60.5 bits (145), Expect = 1e-08
Identities = 35/91 (38%), Positives = 54/91 (58%), Gaps = 2/91 (2%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYD-VNDQDNAGNTPLHEAALNGHSAIVELLVRNGA 317
G T L A DKG D+ K+L++ + + ++ +G PLH AA+ GH AIVE+L+ + A
Sbjct: 129 GETALFTAADKGHLDVVKELLKYSSRESIAKKNRSGYDPLHIAAIQGHHAIVEVLLDHDA 188
Query: 318 NVNIQSYDMFLDTPLIDASANGHINVVKYLL 348
++ Q++ TPL+ A+ GH VV LL
Sbjct: 189 TLS-QTFGPSNATPLVSAAMRGHTEVVNQLL 218
>7296935 [R] KOG0504 FOG: Ankyrin repeat
Length = 325
Score = 60.5 bits (145), Expect = 1e-08
Identities = 46/135 (34%), Positives = 65/135 (48%), Gaps = 4/135 (2%)
Query: 248 KTKRGVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSA 307
K + + RD T L A G + K L++E DVN AG T LH AA+ GH
Sbjct: 192 KKGQSMARDDCDYTALHYAARNGNEPICKLLLDEGKADVNAVTKAGATALHRAAMMGHLE 251
Query: 308 IVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIES 367
IV+LLV + AN+ +Q D T L A GH+ V + LL +PT+ K +
Sbjct: 252 IVKLLVEHKANLLLQ--DESGQTALHRAVMRGHLEVCRILL--AKEPTLKLVKDKKDKIA 307
Query: 368 IEEESDMDNDDRRIV 382
E + NDD +++
Sbjct: 308 FEYIMENANDDFKLL 322
>Hs10190676_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 280
Score = 60.1 bits (144), Expect = 2e-08
Identities = 47/177 (26%), Positives = 80/177 (44%), Gaps = 11/177 (6%)
Query: 250 KRGVHRDAGGRTK---LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHS 306
+RGV G+ L A +G + K L ++ G VN Q G TPLH AA GH
Sbjct: 54 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 113
Query: 307 AIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+ +L+ ++VN+ S + TPL A+ GH + + LL GA V + G +A+
Sbjct: 114 RVARILIDLCSDVNVCS--LLAQTPLHVAAETGHTSTARLLLHRGAGKKAVTSDGYTALH 171
Query: 367 SIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHD 423
+ + +V + D+L R + L ++ HS+ +++ ++ D
Sbjct: 172 LAARNGHLAT-VKLLVEEKADVLARGPL-----NQTALHLAAAHGHSEVVEELVSAD 222
Score = 57.8 bits (138), Expect = 8e-08
Identities = 38/99 (38%), Positives = 54/99 (54%), Gaps = 4/99 (4%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D GRT + +AC G+ ++ + L+ G DV+ Q PLH AA GH IV+LL +
Sbjct: 30 DFEGRTPMHVACQHGQENIVRILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 88
Query: 316 -GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGAD 353
G +VN Q+ D TPL A+ GH V + L+D +D
Sbjct: 89 PGVSVNAQTLDG--RTPLHLAAQRGHYRVARILIDLCSD 125
Score = 54.3 bits (129), Expect = 9e-07
Identities = 32/87 (36%), Positives = 48/87 (54%), Gaps = 3/87 (3%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T L A G + L+E++ VN+ D G TP+H A +G IV +L+R G +V+
Sbjct: 2 TALHFAAQNGDESSTRLLLEKNA-SVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVS 60
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYL 347
+Q D +L PL A+ GH+ +VK L
Sbjct: 61 LQGKDAWL--PLHYAAWQGHLPIVKLL 85
>Hs13899329 [R] KOG0504 FOG: Ankyrin repeat
Length = 854
Score = 59.7 bits (143), Expect = 2e-08
Identities = 33/95 (34%), Positives = 55/95 (57%), Gaps = 1/95 (1%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +AC +G ++ + L++E G D + + + G TPLH AA GHS ++ LV + +
Sbjct: 172 GATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLV-SCTD 230
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGAD 353
V++ D T + A++ GH V+ +LL HG +
Sbjct: 231 VSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGE 265
Score = 51.2 bits (121), Expect = 8e-06
Identities = 31/108 (28%), Positives = 55/108 (50%), Gaps = 3/108 (2%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L A G + L+ +++QD G T +H AA GH+ ++ L+ +G
Sbjct: 206 GMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGE 265
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+ S D++ TPL DA+ NG + + L+ +GA+ + + G +A +
Sbjct: 266 I---SADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAAD 310
>At3g04710_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 333
Score = 59.7 bits (143), Expect = 2e-08
Identities = 70/303 (23%), Positives = 124/303 (40%), Gaps = 52/303 (17%)
Query: 226 SSSIENSSNHKKQKHSAGKKIPKTKRGVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYD 285
+ ++E N KQ GK + KT + +DA R L A +G+ ++ + L+EE +
Sbjct: 24 TGNLEFLKNVAKQLDE-GKDLTKTVESI-KDANKRGALHFAAREGQTEICRYLLEELKLN 81
Query: 286 VNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVK 345
+ +D G+TPL AA G V+ L+ GA+ NI S T L A+ G I ++K
Sbjct: 82 ADAKDETGDTPLVHAARQGQIETVKYLLEQGADPNIAS--ELGATALHHAAGTGEIELLK 139
Query: 346 YLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQ 405
LL G + G I + HD K+ A ++H+
Sbjct: 140 ELLSRGVPVDSESESGTPLIWAAG-------------HDQKN----AVEVLLEHN----- 177
Query: 406 SSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFR 465
++ + D+I LL A G L+ + ++ G + +
Sbjct: 178 ANPNAETEDNI---------------------TPLLSAVAAGSLSCLELLVKAGAKANVF 216
Query: 466 CFLESCIY-----GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGA 520
+ ++ G+ ++++ L GA N ++EG PL ++ R + VV++L
Sbjct: 217 AGGATPLHIAADIGNLELINCLLKAGADPNQKDEEGNRPLEVAAARDNRKVVEILFPLTT 276
Query: 521 DPQ 523
P+
Sbjct: 277 KPE 279
>CE07175 [R] KOG0508 Ankyrin repeat protein
Length = 656
Score = 59.3 bits (142), Expect = 3e-08
Identities = 38/113 (33%), Positives = 58/113 (50%), Gaps = 8/113 (7%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDG-------YDVNDQDNAGNTPLHEAALNGHSAI 308
D GR L IA G ++ + L+E + ++++ G PL A+ GH I
Sbjct: 45 DQDGRYPLVIAARNGHANVVEYLLEIGADPSVRGVVEFDNENIQGTPPLWAASAAGHIEI 104
Query: 309 VELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
V+LL+ AN ++ TPL A +GH+++VKYLL+ GADP + N G
Sbjct: 105 VKLLIEK-ANADVNQATNTRSTPLRGACYDGHLDIVKYLLEKGADPHIPNRHG 156
Score = 53.5 bits (127), Expect = 2e-06
Identities = 44/146 (30%), Positives = 80/146 (54%), Gaps = 24/146 (16%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L IA + K + ++L++ G DVN + GNT LH+AA +G+ +V++L+++G+
Sbjct: 156 GHTCLMIASYRNKVGIVEELLKT-GIDVNKKTERGNTALHDAAESGNVEVVKILLKHGSV 214
Query: 319 V--NIQSYDMFLDTPLIDASANGHINVVKYLLD------HGAD------PTMVNAK--GL 362
+ +IQ D PL+ A+ +G ++V+ L D H D T+++ K +
Sbjct: 215 LMKDIQGVD-----PLMGAALSGFLDVLNVLADQMPSGIHKRDALKLLGSTLLDKKMDAM 269
Query: 363 SAIESIEE--ESDMDNDDRRIVHDMK 386
SA+ ++ E + DD R+V +M+
Sbjct: 270 SAMNCWKQSMEVPLHADDLRLVREME 295
Score = 51.6 bits (122), Expect = 6e-06
Identities = 28/70 (40%), Positives = 39/70 (55%)
Query: 470 SCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRK 529
+C GH D+V L GA ++ N+ G T LM++ R V +V+ LL+ G D K +R
Sbjct: 130 ACYDGHLDIVKYLLEKGADPHIPNRHGHTCLMIASYRNKVGIVEELLKTGIDVNKKTERG 189
Query: 530 KTALHYANHS 539
TALH A S
Sbjct: 190 NTALHDAAES 199
>7302342 [R] KOG0508 Ankyrin repeat protein
Length = 332
Score = 59.3 bits (142), Expect = 3e-08
Identities = 37/99 (37%), Positives = 57/99 (57%), Gaps = 3/99 (3%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
H + L+ AC +G+ D+ + LI+ +G DVN + N L AA GH +V+ L+
Sbjct: 171 HNTKAQSSPLRAACYEGRLDIVEFLID-NGADVNATNLFNNNTLMIAAYKGHHLVVKTLL 229
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGA 352
+NG+ N Q+ + T L A+ +GH++VV LLDHGA
Sbjct: 230 QNGSRANDQA--LCGATALHYAAESGHLDVVVALLDHGA 266
Score = 55.8 bits (133), Expect = 3e-07
Identities = 38/117 (32%), Positives = 58/117 (49%), Gaps = 3/117 (2%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L +A G + K L++ G +N A ++PL A G IVE L+ NGA+
Sbjct: 143 GATALWVAAGMGHLQIVKMLVQA-GAAINHNTKAQSSPLRAACYEGRLDIVEFLIDNGAD 201
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
VN + ++F + L+ A+ GH VVK LL +G+ G +A+ E +D
Sbjct: 202 VN--ATNLFNNNTLMIAAYKGHHLVVKTLLQNGSRANDQALCGATALHYAAESGHLD 256
>7301583 [R] KOG0504 FOG: Ankyrin repeat
Length = 1162
Score = 59.3 bits (142), Expect = 3e-08
Identities = 62/253 (24%), Positives = 104/253 (40%), Gaps = 33/253 (13%)
Query: 290 DNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLD 349
D G TPLH A + G+ A+V LL+ N A+VN + D + + A+ G + ++ +L
Sbjct: 68 DEDGFTPLHLAVIQGNLAMVNLLLANKADVN--AVDNEGHSVVHWATVCGEVESLRAVLA 125
Query: 350 HGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSSM 409
GA +A G + + + D S + SS+
Sbjct: 126 AGASVAKPDANGGTPLHYAAQMCGASKQD---------------------SKQQASSSNS 164
Query: 410 SRHSDDI-DKQLNHDDDFYWTDISSKLGKNKLLKASKEGK------LAYVGSYLENGGRP 462
SR S +I L+H D+ K G+ LL A+ G L G+ +E+ +
Sbjct: 165 SRLSLEILGILLSHPQSS--VDVQDKDGRQPLLWAASAGSAKAVIALVKAGARVESSDKD 222
Query: 463 DFRCFLESCIYGHDDVVSLFLAF-GAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGAD 521
+ GH + + + GA ++ + G T L +V GH + LL+ AD
Sbjct: 223 GLTALHCAGSRGHTECIDTLIGLCGAPTDLIDSNGCTALHYAVTLGHADATARLLDLEAD 282
Query: 522 PQKTDKRKKTALH 534
P + D++ +T H
Sbjct: 283 PNRQDRKGRTPAH 295
Score = 55.1 bits (131), Expect = 5e-07
Identities = 37/100 (37%), Positives = 58/100 (58%), Gaps = 4/100 (4%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVE-LLV 313
+D GRT C KG+++ K L++E G ++ ++ G+ PLHEAA +G ++E LL
Sbjct: 286 QDRKGRTPAHCGCSKGQFETLK-LLKERGANLWLRNAKGDLPLHEAAASGRRELLEWLLA 344
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGAD 353
+ VN S D + L A+AN + ++ K LLD+GAD
Sbjct: 345 QRPKQVNTTSNDG--RSLLHIAAANDYTDMCKLLLDYGAD 382
>Hs7706007 [R] KOG0504 FOG: Ankyrin repeat
Length = 175
Score = 58.9 bits (141), Expect = 4e-08
Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 270 GKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLD 329
G K LI++ D + D+AG T LH A+ NGH A+ + L+ +GA + Q++
Sbjct: 42 GDLGRVKHLIQK-AEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG--A 98
Query: 330 TPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
T L AS GH + + LL HG++P +V+ G++++ E D
Sbjct: 99 TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGD 144
>Hs13129098 [R] KOG0504 FOG: Ankyrin repeat
Length = 288
Score = 58.9 bits (141), Expect = 4e-08
Identities = 38/113 (33%), Positives = 60/113 (52%), Gaps = 4/113 (3%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D RT L A +K + +++ E G + N D +TPLH AA ++ V L+ +
Sbjct: 83 DGYNRTALHYAAEKD--EACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLES 140
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESI 368
GA+VN Y+ DTPL A+ G++ V LLD+GA+ ++N G + I +
Sbjct: 141 GASVNALDYNN--DTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRL 191
>CE17993 [R] KOG0504 FOG: Ankyrin repeat
Length = 1208
Score = 58.5 bits (140), Expect = 5e-08
Identities = 42/155 (27%), Positives = 74/155 (47%), Gaps = 17/155 (10%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G T L A K + + + + G VN +DN G TPL EA + V +L+R GA
Sbjct: 563 GETVLHQAAMKSENEAVIERLCRRGCKVNAKDNGGWTPLSEAVAHNQYGNVLVLLRYGAE 622
Query: 319 VNIQSYDMFLD---------------TPLIDASANGHINVVKYLLDHGADPTMVNAKGLS 363
VN +S + F+ TPL++A NG++++ + L+D+ A + ++ G +
Sbjct: 623 VNARSAESFMSEESQNSSTELNHSRLTPLMEACTNGYVDIAQLLIDNRASVDLRDSAGWT 682
Query: 364 AIESIEEESDMDNDDRRIVHDMK--DMLKRATRKY 396
A + ++ E +++ +K + LK T Y
Sbjct: 683 AYQHLKYERRFIDENEYTERHLKFAENLKILTANY 717
>At4g27780 [I] KOG0817 Acyl-CoA-binding protein
Length = 354
Score = 58.5 bits (140), Expect = 5e-08
Identities = 31/71 (43%), Positives = 43/71 (59%), Gaps = 1/71 (1%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
RD+ GRT L A D+G ++AK L++++ DVN +DN G TPLH A + AI E LV+
Sbjct: 262 RDSEGRTPLHWAIDRGHLNIAKVLVDKNA-DVNAKDNEGQTPLHYAVVCDREAIAEFLVK 320
Query: 315 NGANVNIQSYD 325
AN + D
Sbjct: 321 QNANTAAKDED 331
>At2g03430 [O] KOG4412 26S proteasome regulatory complex subunit PSMD10
Length = 247
Score = 58.5 bits (140), Expect = 5e-08
Identities = 38/111 (34%), Positives = 59/111 (52%), Gaps = 3/111 (2%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+D G L A G +L + L+ G DVN ++N G T LH AA G I +LL+
Sbjct: 79 KDDEGWAPLHSAASIGNAELVEVLLTR-GADVNAKNNGGRTALHYAASKGRLEIAQLLLT 137
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
+GA +NI D TPL A++ G + V ++L++ GA+ + G +A+
Sbjct: 138 HGAKINIT--DKVGCTPLHRAASVGKLEVCEFLIEEGAEIDATDKMGQTAL 186
Score = 55.5 bits (132), Expect = 4e-07
Identities = 40/140 (28%), Positives = 68/140 (48%), Gaps = 17/140 (12%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYD--VNDQDNAGNTPLHEAALNGHSAIVELL 312
R+ GR+ L +A G + K L D +N +D+ G PLH AA G++ +VE+L
Sbjct: 43 RNEDGRSLLHVAASFGHSQIVKLLSSSDEAKTVINSKDDEGWAPLHSAASIGNAELVEVL 102
Query: 313 VRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIES----- 367
+ GA+VN ++ T L A++ G + + + LL HGA + + G + +
Sbjct: 103 LTRGADVNAKNNGG--RTALHYAASKGRLEIAQLLLTHGAKINITDKVGCTPLHRAASVG 160
Query: 368 --------IEEESDMDNDDR 379
IEE +++D D+
Sbjct: 161 KLEVCEFLIEEGAEIDATDK 180
>7297584 [R] KOG0502 Integral membrane ankyrin-repeat protein Kidins220
(protein kinase D substrate)
Length = 237
Score = 58.5 bits (140), Expect = 5e-08
Identities = 33/81 (40%), Positives = 51/81 (62%), Gaps = 2/81 (2%)
Query: 285 DVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVV 344
+++ +D G T LH AA G V+LLV GANVN + D+ +PL+ A+A GH +V
Sbjct: 95 NIDYKDAHGFTALHWAASYGQLVSVQLLVAAGANVNTMAPDLI--SPLLLAAAGGHNEIV 152
Query: 345 KYLLDHGADPTMVNAKGLSAI 365
++LL+HGAD ++ G +A+
Sbjct: 153 RFLLEHGADSGHMDIVGNTAL 173
>Hs12746412 [R] KOG0502 Integral membrane ankyrin-repeat protein Kidins220
(protein kinase D substrate)
Length = 313
Score = 58.2 bits (139), Expect = 6e-08
Identities = 34/93 (36%), Positives = 48/93 (51%), Gaps = 6/93 (6%)
Query: 436 GKNKLLKASKEGKLAYVGSYLENGGRPDF------RCFLESCIYGHDDVVSLFLAFGAQV 489
G L+ A+ G++A V L+NG P +C G+ D+V + L G V
Sbjct: 182 GFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDV 241
Query: 490 NMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADP 522
N + G TPL+ +V HV VK+LLE+GADP
Sbjct: 242 NEYDWNGGTPLLYAVHGNHVKCVKMLLESGADP 274
Score = 53.1 bits (126), Expect = 2e-06
Identities = 39/134 (29%), Positives = 60/134 (44%), Gaps = 33/134 (24%)
Query: 264 QIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN----- 318
Q+A LA ++ +E+ +N D G TPL AA +G A+VE L++NGA+
Sbjct: 155 QLAAQGEMLYLATRIEQENV--INHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLG 212
Query: 319 --------------------------VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGA 352
V++ YD TPL+ A H+ VK LL+ GA
Sbjct: 213 KGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGA 272
Query: 353 DPTMVNAKGLSAIE 366
DPT+ G ++++
Sbjct: 273 DPTIETDSGYNSMD 286
>Hs14744423 [R] KOG0504 FOG: Ankyrin repeat
Length = 333
Score = 57.4 bits (137), Expect = 1e-07
Identities = 37/113 (32%), Positives = 56/113 (48%), Gaps = 6/113 (5%)
Query: 430 DISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFL 483
D + + L +AS EG + + L+NG DF+ L+ +C GH +VV L
Sbjct: 148 DTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQ 207
Query: 484 AFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ GA N+ +K TPL ++V G V +V+ L G + D+ TALH A
Sbjct: 208 SHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDA 260
Score = 54.7 bits (130), Expect = 7e-07
Identities = 36/113 (31%), Positives = 56/113 (48%), Gaps = 6/113 (5%)
Query: 430 DISSKLGKNKLLKASKEGKLAYVGSYLENGGRPD----FR--CFLESCIYGHDDVVSLFL 483
+I+ + + LKA+ EGK+ + +L +GG D FR + + GH +++ L
Sbjct: 115 EITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLL 174
Query: 484 AFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
GA V+ ++ T + + GH+ VVKLL GAD DK T LH A
Sbjct: 175 DNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVA 227
Score = 54.7 bits (130), Expect = 7e-07
Identities = 40/98 (40%), Positives = 51/98 (51%), Gaps = 4/98 (4%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
A +GK + +K + DG + D T LH A+L GH I+E L+ NGA V+ Q D
Sbjct: 128 AAVEGKMKVIEKFLA-DGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ--D 184
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLS 363
T + A GH+ VVK L HGAD T V K LS
Sbjct: 185 RLDCTAMHWACRGGHLEVVKLLQSHGAD-TNVRDKLLS 221
Score = 53.1 bits (126), Expect = 2e-06
Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 3/109 (2%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T + AC G ++ K L++ G D N +D +TPLH A G IVE + G +N
Sbjct: 189 TAMHWACRGGHLEVVK-LLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 247
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIE 369
+ D DT L DA ++K LL HGAD N G + + ++
Sbjct: 248 AR--DREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQ 294
>Hs13540484 [R] KOG0504 FOG: Ankyrin repeat
Length = 333
Score = 57.4 bits (137), Expect = 1e-07
Identities = 37/113 (32%), Positives = 56/113 (48%), Gaps = 6/113 (5%)
Query: 430 DISSKLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFL 483
D + + L +AS EG + + L+NG DF+ L+ +C GH +VV L
Sbjct: 148 DTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQ 207
Query: 484 AFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
+ GA N+ +K TPL ++V G V +V+ L G + D+ TALH A
Sbjct: 208 SHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDA 260
Score = 54.7 bits (130), Expect = 7e-07
Identities = 36/113 (31%), Positives = 56/113 (48%), Gaps = 6/113 (5%)
Query: 430 DISSKLGKNKLLKASKEGKLAYVGSYLENGGRPD----FR--CFLESCIYGHDDVVSLFL 483
+I+ + + LKA+ EGK+ + +L +GG D FR + + GH +++ L
Sbjct: 115 EITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLL 174
Query: 484 AFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
GA V+ ++ T + + GH+ VVKLL GAD DK T LH A
Sbjct: 175 DNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVA 227
Score = 54.7 bits (130), Expect = 7e-07
Identities = 40/98 (40%), Positives = 51/98 (51%), Gaps = 4/98 (4%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
A +GK + +K + DG + D T LH A+L GH I+E L+ NGA V+ Q D
Sbjct: 128 AAVEGKMKVIEKFLA-DGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ--D 184
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLS 363
T + A GH+ VVK L HGAD T V K LS
Sbjct: 185 RLDCTAMHWACRGGHLEVVKLLQSHGAD-TNVRDKLLS 221
Score = 53.1 bits (126), Expect = 2e-06
Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 3/109 (2%)
Query: 261 TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN 320
T + AC G ++ K L++ G D N +D +TPLH A G IVE + G +N
Sbjct: 189 TAMHWACRGGHLEVVK-LLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 247
Query: 321 IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIE 369
+ D DT L DA ++K LL HGAD N G + + ++
Sbjct: 248 AR--DREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQ 294
>At5g07840 [R] KOG0504 FOG: Ankyrin repeat
Length = 213
Score = 57.0 bits (136), Expect = 1e-07
Identities = 38/105 (36%), Positives = 56/105 (53%), Gaps = 5/105 (4%)
Query: 252 GVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVN----DQDNAGNTPLHEAALNGHSA 307
GV RD G T+L I +G K+L+++ G DVN + G TPLH AA GH
Sbjct: 62 GVDRDDRGWTQLHIKAREGDLKAVKELLDQ-GADVNALACGPKSKGMTPLHLAAKGGHIE 120
Query: 308 IVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGA 352
+++LL+ GAN+ ++ TPL A+ VK+L+ +GA
Sbjct: 121 VMDLLLERGANMEARTSGACGWTPLHAAAKERKREAVKFLVGNGA 165
>At3g09890 [R] KOG0504 FOG: Ankyrin repeat
Length = 185
Score = 57.0 bits (136), Expect = 1e-07
Identities = 37/105 (35%), Positives = 56/105 (53%), Gaps = 8/105 (7%)
Query: 263 LQIACDKGKYDLAKKLIEEDG-YDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVN- 320
L +AC G + L+E +V D+D A PLH+A G+ IV+LL ++
Sbjct: 77 LHLACLYGHLPCVQLLLERGADMEVKDEDEA--IPLHDACAGGYLEIVQLLFSRASSPEC 134
Query: 321 ----IQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
I++ D+ DTPL A+ H++VV++LL GA PT N+ G
Sbjct: 135 VKRMIETADIEGDTPLHHAARGEHVDVVRFLLGSGASPTTQNSYG 179
>CE28110 [T] KOG0521 Putative GTPase activating proteins (GAPs)
Length = 826
Score = 56.6 bits (135), Expect = 2e-07
Identities = 41/110 (37%), Positives = 55/110 (49%), Gaps = 4/110 (3%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
AC+ G LA G+D+N N G T LH A NG +A VE L+ NGA +N+ D
Sbjct: 666 ACECGDL-LALMTAYAQGFDLNALHN-GTTALHIATRNGQTAAVEFLLLNGAKINM--LD 721
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
L+TPL A+ GH V LL GAD + N + ++ E + D
Sbjct: 722 EKLNTPLHLAAKEGHTLPVCQLLKRGADSNLANVDSKTPLDIAMECTHAD 771
>CE27723 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 850
Score = 56.6 bits (135), Expect = 2e-07
Identities = 34/107 (31%), Positives = 59/107 (54%), Gaps = 5/107 (4%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNA-GNTPLHEAALNGHSA-IVELL 312
R+ G T L ++C G+ D+ K +++ ++ + +N TPLH A G S +V L
Sbjct: 282 RNLYGDTALHLSCYSGRLDIVKSILDSSPTNIVNMENVFSETPLHAACTGGKSIELVSFL 341
Query: 313 VRN-GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVN 358
++ G + N Q D T L A +GH+ +V+YLL++GAD ++ +
Sbjct: 342 MKYPGVDPNYQGQDGH--TALHSACYHGHLRIVQYLLENGADQSLAS 386
>CE25223 [T] KOG0521 Putative GTPase activating proteins (GAPs)
Length = 742
Score = 56.6 bits (135), Expect = 2e-07
Identities = 41/110 (37%), Positives = 55/110 (49%), Gaps = 4/110 (3%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
AC+ G LA G+D+N N G T LH A NG +A VE L+ NGA +N+ D
Sbjct: 582 ACECGDL-LALMTAYAQGFDLNALHN-GTTALHIATRNGQTAAVEFLLLNGAKINM--LD 637
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
L+TPL A+ GH V LL GAD + N + ++ E + D
Sbjct: 638 EKLNTPLHLAAKEGHTLPVCQLLKRGADSNLANVDSKTPLDIAMECTHAD 687
>CE20486 [OT] KOG0505 Myosin phosphatase regulatory subunit
Length = 1016
Score = 56.6 bits (135), Expect = 2e-07
Identities = 38/123 (30%), Positives = 71/123 (56%), Gaps = 6/123 (4%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
AC G + ++L+ + G ++N G T LH++ ++ +V L GA+VN Q +
Sbjct: 62 ACMSGDEEEVEELLNK-GANINTCTVDGLTALHQSVIDSKPEMVRFLCEKGADVNAQDNE 120
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNA-KGLSAIESIEEE--SDMDNDDRRIV 382
+ TPL A+ G++ +V+YL HGAD ++VN+ K L+ +++E+ +D+D +R +
Sbjct: 121 GW--TPLHAAACCGNVAIVRYLCQHGADLSIVNSDKELALDLAVDEQCRDYLDDDYKRQM 178
Query: 383 HDM 385
D+
Sbjct: 179 IDL 181
>7296403 [T] KOG0195 Integrin-linked kinase
Length = 448
Score = 56.6 bits (135), Expect = 2e-07
Identities = 34/95 (35%), Positives = 54/95 (56%), Gaps = 2/95 (2%)
Query: 267 CDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDM 326
C +G + ++E +D N D+ G +PLH A GH+ +VE L++ G+ VN + +M
Sbjct: 8 CREGNSIQVRLWLDETEHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVN--ATNM 65
Query: 327 FLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
D PL A+A+GH +VV+ L+ +D VN G
Sbjct: 66 GDDIPLHLAAAHGHRDVVQMLIKERSDVNAVNEHG 100
>Hs8923181 [K] KOG0512 Fetal globin-inducing factor (contains ankyrin repeats)
Length = 239
Score = 56.2 bits (134), Expect = 2e-07
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 7/99 (7%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
A +K + ++L+ E VN +D TPLH AA +GH IV+ L+ GA+V+ + D
Sbjct: 81 AAEKNRLTTVRRLLSEKATHVNTRDEDEYTPLHRAAYSGHLDIVQELIAQGADVHAVTVD 140
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNA--KGL 362
+ TPL A + V +LL H AD +NA KGL
Sbjct: 141 GW--TPLHSACKWNNTRVASFLLQHDAD---INAQTKGL 174
>Hs4506217 [O] KOG4412 26S proteasome regulatory complex subunit PSMD10
Length = 226
Score = 56.2 bits (134), Expect = 2e-07
Identities = 37/99 (37%), Positives = 54/99 (54%), Gaps = 3/99 (3%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D RT L AC G ++ + L++ G VND+D+AG +PLH AA G IV+ L+
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQL-GVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADP 354
GA VN + + TPL A++ + LL+ GA+P
Sbjct: 96 GAQVNAVNQNGC--TPLHYAASKNRHEIAVMLLEGGANP 132
Score = 51.6 bits (122), Expect = 6e-06
Identities = 25/63 (39%), Positives = 35/63 (54%)
Query: 474 GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTAL 533
G D++V L GAQVN N+ G TPL + + + +LLE GA+P D + TA+
Sbjct: 84 GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
Query: 534 HYA 536
H A
Sbjct: 144 HRA 146
>At4g32500 [PT] KOG0498 K+-channel ERG and related proteins contain PAS/PAC
sensor domain
Length = 880
Score = 56.2 bits (134), Expect = 2e-07
Identities = 35/120 (29%), Positives = 58/120 (48%), Gaps = 5/120 (4%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D GRT L IA KG L+E G D N +D+ G+ PL EA + H +LL N
Sbjct: 572 DKNGRTALHIAASKGSQYCVVLLLEH-GADPNIRDSEGSVPLWEAIIGRHEENAKLLSEN 630
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMD 375
GA ++ + F A ++N +K ++ +G D ++ + G +A+ E +++
Sbjct: 631 GATLSFDTVGYFSCL----AVGQNNLNALKDIVKYGGDISLSDVNGTTALHRAVSEGNLE 686
>7290390 [T] KOG1217 Fibrillins and related proteins containing Ca2+-binding
EGF-like domains
Length = 2634
Score = 55.8 bits (133), Expect = 3e-07
Identities = 39/111 (35%), Positives = 58/111 (52%), Gaps = 4/111 (3%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D G T L +A + D AK+L++ G D N QDN G TPLH A + ++L+RN
Sbjct: 1948 DKTGETSLHLAARFARADAAKRLLDA-GADANCQDNTGRTPLHAAVAADAMGVFQILLRN 2006
Query: 316 GA-NVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
A N+N + +D TPLI A+ +V+ L+ AD + G +A+
Sbjct: 2007 RATNLNARMHDG--TTPLILAARLAIEGMVEDLITADADINAADNSGKTAL 2055
>7294632_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 959
Score = 55.8 bits (133), Expect = 3e-07
Identities = 47/141 (33%), Positives = 73/141 (51%), Gaps = 18/141 (12%)
Query: 400 SHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLK-ASKEGKLAYVGSYLEN 458
S R LQS ++ +D+I L + Y ++ K+ + LL AS + Y+G
Sbjct: 384 SPRDLQSYWLAGAADNISSSLGALRNVYSPNL--KVSRLVLLAGASPNHRTDYMG----- 436
Query: 459 GGRPDFRCFLESCIYGHDDV---VSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLL 515
G P CI H+ + VSL L FGA V ++N +G TPL+L+ RGH +VV+ L
Sbjct: 437 -GAPIL------CIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPL 489
Query: 516 LEAGADPQKTDKRKKTALHYA 536
+ AG+ + D ++ AL +A
Sbjct: 490 VAAGSSLGQLDITQRCALVHA 510
Score = 52.0 bits (123), Expect = 4e-06
Identities = 68/266 (25%), Positives = 110/266 (40%), Gaps = 29/266 (10%)
Query: 290 DNAGNTP-LHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLL 348
D G P L AA G +V LL+ GA+V + + TPLI A+ GH +VV+ L+
Sbjct: 433 DYMGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGC--TPLILAAMRGHCDVVRPLV 490
Query: 349 DHGAD---------PTMVNAKGLSAIESIEEESDMDNDDRRIVHDM--KDMLKRATRKYI 397
G+ +V+A + + ++ D R D+ L++A
Sbjct: 491 AAGSSLGQLDITQRCALVHAARMGHLSVVKYLLACDWSPRPHSQDVTRSVALQQALIGAA 550
Query: 398 KHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLE 457
+H + + + + D +N + G+ L A++ G + VG L
Sbjct: 551 AQAHCKILEDLLDLNETEFDLDVN--------GMEPSSGELALTAAARHGCIDVVGILLS 602
Query: 458 NGGRPDFR------CFLESCIYGHDDVVSLFLAFGAQVNMS-NKEGQTPLMLSVGRGHVN 510
G + D R + GH VV L GA ++ + +TPLM++ GH+
Sbjct: 603 RGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLE 662
Query: 511 VVKLLLEAGADPQKTDKRKKTALHYA 536
+V LLL GA + D TAL +A
Sbjct: 663 LVDLLLARGAQREAQDHEGFTALSWA 688
>CE19848_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 185
Score = 55.8 bits (133), Expect = 3e-07
Identities = 37/117 (31%), Positives = 57/117 (48%), Gaps = 1/117 (0%)
Query: 254 HRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLV 313
H ++ +T L AC K ++ K LIE D +N D G T LH AA G+ IV LV
Sbjct: 58 HTNSNKQTSLHYACSKNHVEIVKLLIEADPNIINLPDKFGATALHRAASRGNDVIVRALV 117
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEE 370
G ++ D +T L A +V L++ GAD M+N + + +E +++
Sbjct: 118 STG-KCSLDRQDGEGNTALHLACDENRGDVAILLVNRGADMKMLNKEKQTPLEMLKD 173
>Hs7662406 [R] KOG0504 FOG: Ankyrin repeat
Length = 692
Score = 55.5 bits (132), Expect = 4e-07
Identities = 37/113 (32%), Positives = 62/113 (54%), Gaps = 3/113 (2%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
++ G T L +AC + + + +++ G + ++NAG+T LH AA H +I+ LL+
Sbjct: 137 KNKAGNTALHLAC-QNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLT 195
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIES 367
A ++ + DT L A+A H V K LL+ GAD T+VN G + +E+
Sbjct: 196 --AFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLET 246
Score = 51.2 bits (121), Expect = 8e-06
Identities = 64/279 (22%), Positives = 120/279 (42%), Gaps = 20/279 (7%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
GRT L +A +KG + + L++ G D++ QD+ T LH A + G++ I+ L+ G
Sbjct: 42 GRTPLHLAANKGHLPVVQILLKA-GCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCA 100
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDD 378
++ Q D +T L +AS +G K L+ GA+ N G +A+ + S +
Sbjct: 101 LDRQDKDG--NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTR 158
Query: 379 RRIVHDMKDMLKR-----ATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISS 433
++ + LK +++H ++ ++ +K D + +++
Sbjct: 159 VLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALH---VAA 215
Query: 434 KLGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSN 493
L K+ K E + + N G+ LE+ Y ++ V+L L Q ++S
Sbjct: 216 ALNHKKVAKILLEA--GADTTIVNNAGQTP----LETARYHNNPEVALLLTKAPQGSVS- 268
Query: 494 KEGQTPLMLSVGRGHVNVVKLLLEAGADPQ-KTDKRKKT 531
G TP + L A +P+ K D+R+K+
Sbjct: 269 -AGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKS 306
>Hs22004647 [R] KOG0504 FOG: Ankyrin repeat
Length = 460
Score = 55.5 bits (132), Expect = 4e-07
Identities = 56/164 (34%), Positives = 79/164 (48%), Gaps = 13/164 (7%)
Query: 249 TKRGVH-RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSA 307
TKR ++ D G T +A G + A ++I G D + D GNTPLH AA NGH+
Sbjct: 21 TKRDLNLSDEDGMTPTLLAAYHGNLE-ALEIICSRGGDPDRCDIWGNTPLHFAASNGHAH 79
Query: 308 IVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIES 367
V LV GA NI + D L TPL DA+A+ N LLD A T N +
Sbjct: 80 CVSFLVNFGA--NIFALDNDLQTPL-DAAASREQNECVALLDKAA--TAQNIMNPKKVTR 134
Query: 368 IEEESDMDNDDRRIVHDMKDMLKRATRK----YIKHSHRTLQSS 407
++E++ + RR + + + + ++ K Y K TL SS
Sbjct: 135 LKEQA--QKNARRQIKECERLQEKHQNKMAHTYSKEESGTLSSS 176
>Hs13443014 [R] KOG0504 FOG: Ankyrin repeat
Length = 262
Score = 55.5 bits (132), Expect = 4e-07
Identities = 60/236 (25%), Positives = 105/236 (44%), Gaps = 50/236 (21%)
Query: 272 YDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTP 331
+ L+ + + G+ VN +PLHEA L GH + V++L+++GA VN + D TP
Sbjct: 48 HQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW--HTP 105
Query: 332 LIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKR 391
L +A +G + V LL HGA S++ ESD+ + +H+
Sbjct: 106 LFNACVSGSWDCVNLLLQHGA--------------SVQPESDLASP----IHE------A 141
Query: 392 ATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAY 451
A R +++ +S+ + +ID +++H LG L A + + A
Sbjct: 142 ARRGHVE------CVNSLIAYGGNIDHKISH------------LG-TPLYLACENQQRAC 182
Query: 452 VGSYLENGGRPDFRCFLESCIY-----GHDDVVSLFLAFGAQVNMSNKEGQTPLML 502
V LE+G + +S ++ +++ L + FGA N EG+ P+ L
Sbjct: 183 VKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 238
>At2g17390 [R] KOG0504 FOG: Ankyrin repeat
Length = 344
Score = 55.5 bits (132), Expect = 4e-07
Identities = 55/222 (24%), Positives = 92/222 (40%), Gaps = 32/222 (14%)
Query: 130 NKHSDEEYSSALSEVESDAPTEPASPPRPKMGRLIRGDQLESGNNSRQ----SSAPVLTN 185
N + E+++ +++++ D +P ++++G S + VL
Sbjct: 145 NPAASEQFAERMAQMKEDPELKPILA------------EIDAGGPSAMMKYWNDKDVLAK 192
Query: 186 DGEXXXXXXXXXEARTAKISSSAIHEDSSPVKHYNEHKRKSSSIENSSNHKKQKHSAGKK 245
GE + A+ + E+ + H +++S+ + K S G K
Sbjct: 193 LGEAMGIAVGADQTVAAEPEEAEEGEEEESIVH------QTASLGDVEGLKAALASGGNK 246
Query: 246 IPKTKRGVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGH 305
+ D+ GRT L AC G+ A+ L++ G + N D NTPLH AA G
Sbjct: 247 DEE-------DSEGRTALHFACGYGEVRCAQVLLDA-GANANAIDKNKNTPLHYAAGYGR 298
Query: 306 SAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYL 347
V LL+ NGA V Q+ D P+ A N ++VVK L
Sbjct: 299 KECVSLLLENGAAVTQQNMDN--KNPIDVARLNNQLDVVKLL 338
>CE05333 [R] KOG0510 Ankyrin repeat protein
Length = 1188
Score = 55.1 bits (131), Expect = 5e-07
Identities = 64/280 (22%), Positives = 113/280 (39%), Gaps = 16/280 (5%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L +A + ++ LIEE+ +++ D G TPL A + VE L+ AN+ I
Sbjct: 331 LHVAAQMNQLEVVSYLIEEEKDNIDVVDEQGLTPLMMAVTHDSKKCVEYLIAKKANLTIT 390
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIV 382
D TP+ + ++ V+Y+LDH + + + D RR +
Sbjct: 391 DKDE--RTPVFIGAKFNALSSVEYILDHLRKKNKETERSALKSPTRNTLRIVSEDVRRTM 448
Query: 383 HDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLK 442
+M D + T +I S+ L+ + + Q+N D++ + +G +LL+
Sbjct: 449 VNMVDR-DQNTPMHIVASNGYLEMMQLLQKHGASITQVNEDEETALH--RAAIGVRQLLE 505
Query: 443 ASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLML 502
+ +L + + N + GHD + L GA N +TPL +
Sbjct: 506 --WDIRLLLMKDEMGNS------ALHLAARSGHDATTKVLLDNGADKEAKNSYQKTPLQV 557
Query: 503 SVGRGHVNVVKLLLEAGADPQKTDKRK---KTALHYANHS 539
+V G + + L+ GA + + K TA Y N S
Sbjct: 558 AVDSGKLETCQRLVAKGAQIESSSDTKTVLHTAAFYGNES 597
>Hs7706377 [R] KOG0504 FOG: Ankyrin repeat
Length = 335
Score = 54.7 bits (130), Expect = 7e-07
Identities = 33/91 (36%), Positives = 53/91 (57%), Gaps = 9/91 (9%)
Query: 474 GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTAL 533
GH V + GA+V++ + +GQT L ++V GH+ ++LLEAGADP + + T +
Sbjct: 89 GHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPV 148
Query: 534 HYANHSSLGLTDPDEVNLLKAAVRAKYGYEV 564
++A S +G D +LKA +R YG +V
Sbjct: 149 YHA--SRVGRAD-----ILKALIR--YGADV 170
>7303116 [R] KOG0514 Ankyrin repeat protein
Length = 1224
Score = 54.7 bits (130), Expect = 7e-07
Identities = 74/342 (21%), Positives = 137/342 (39%), Gaps = 59/342 (17%)
Query: 60 VTSTDQNSTKQPSDEPYVVSQANSS---DQKVGSPLNNQESIPVRQAETKGPINEIKQET 116
+TS+ ++ P EP + S ++SS D ++ + S P++ ++++G Q T
Sbjct: 871 MTSSGTTKSESPEQEPAMSSSSDSSPPIDVQIAQGARKKSSTPLKSSQSEG-----SQVT 925
Query: 117 DVEEKKNLPKVGRNKHSDEEYSSALSEVESDAPTEPASPPRPKMGRLIRGDQLESGNNSR 176
+E+ ++ + +D E PR K + +
Sbjct: 926 VIEQPATKAQLHQLAQADSE-------------------PRKK-----------TELSQS 955
Query: 177 QSSAPVLTNDGEXXXXXXXXXEARTAKISSSAIHEDSSPVKHYNEHKRKSSSIENSSNHK 236
A + ND +++ K + + I + H +SS S H+
Sbjct: 956 LKDALKIINDSLLKKLGAKPISSQSLKSAKATIQD----------HWFTNSSTGKSDPHQ 1005
Query: 237 KQKHS---AGKKIPKTKRGVH-RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNA 292
+ + IP + V+ D+ G T + A G +D+ L++ DVN +NA
Sbjct: 1006 VEDYLDYFESLSIPLLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNA 1065
Query: 293 GNTPLHEAAL-----NGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYL 347
G T + +L H +VE L + A+VNI++ T L+ A ++G+ ++V L
Sbjct: 1066 GYTSVMLVSLAKLKQPAHRTVVERLFKM-ADVNIRA-KKHCQTALMLAVSHGNGDMVNML 1123
Query: 348 LDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDML 389
LD GAD + + G +A+ E +D + H D L
Sbjct: 1124 LDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSL 1165
>Hs14150169 [I] KOG0817 Acyl-CoA-binding protein
Length = 282
Score = 54.3 bits (129), Expect = 9e-07
Identities = 34/95 (35%), Positives = 50/95 (51%), Gaps = 2/95 (2%)
Query: 267 CDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDM 326
C + D K I+ DVN +D G LH A GH +V +L+++ A++N Q D
Sbjct: 166 CRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQ--DN 223
Query: 327 FLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
T L ASA +++V+ LL GADPT+ + G
Sbjct: 224 EGQTALHYASACEFLDIVELLLQSGADPTLRDQDG 258
>CE06954 [K] KOG4214 Myotrophin and similar proteins
Length = 114
Score = 54.3 bits (129), Expect = 9e-07
Identities = 34/87 (39%), Positives = 49/87 (56%), Gaps = 4/87 (4%)
Query: 250 KRGVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIV 309
++ VH GRT +QIA D G+ + LI G ++ D+D G TPL A GH V
Sbjct: 21 EKNVHEIYNGRTAIQIAADYGQTSIIAYLI-SIGANIQDKDKYGITPLLSAVWEGHRDAV 79
Query: 310 ELLVRNGANVNIQSYDMFLDTPLIDAS 336
+LL++NGA+ +I + D T LID +
Sbjct: 80 KLLLQNGADRSIHAPD---GTALIDCT 103
Score = 51.6 bits (122), Expect = 6e-06
Identities = 37/102 (36%), Positives = 56/102 (54%), Gaps = 5/102 (4%)
Query: 270 GKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLD 329
G+ D K+ + E +V++ N G T + AA G ++I+ L+ GAN IQ D +
Sbjct: 10 GEIDAVKQSVNEK--NVHEIYN-GRTAIQIAADYGQTSIIAYLISIGAN--IQDKDKYGI 64
Query: 330 TPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEE 371
TPL+ A GH + VK LL +GAD ++ G + I+ EEE
Sbjct: 65 TPLLSAVWEGHRDAVKLLLQNGADRSIHAPDGTALIDCTEEE 106
>Hs13375989 [R] KOG0504 FOG: Ankyrin repeat
Length = 278
Score = 53.9 bits (128), Expect = 1e-06
Identities = 40/105 (38%), Positives = 56/105 (53%), Gaps = 5/105 (4%)
Query: 260 RTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANV 319
RT + A +G+ ++LIE G VN TPLH A+L G + V+LL+ GA V
Sbjct: 20 RTPVHEAAQRGESLQLQQLIES-GACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQV 78
Query: 320 NIQSYDMFLDTPLIDASANGHINVVKYLLDHGA--DPTMVNAKGL 362
+ ++ D TPL DA A+G I VK L +GA +P + A L
Sbjct: 79 DARNIDG--STPLCDACASGSIECVKLSLSYGAKVNPPLYTASPL 121
Score = 52.4 bits (124), Expect = 3e-06
Identities = 41/108 (37%), Positives = 56/108 (50%), Gaps = 7/108 (6%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
R+ G T L AC G + K + G VN + PLHEA ++G S V LL+
Sbjct: 81 RNIDGSTPLCDACASGSIECVKLSLSY-GAKVNPPLYTAS-PLHEACMSGSSECVRLLID 138
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGL 362
GA N++++D TPL A A H++ VK LL+ GA+ VNA L
Sbjct: 139 VGA--NLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN---VNAAKL 181
>7294202 [R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain
containing proteins
Length = 637
Score = 53.9 bits (128), Expect = 1e-06
Identities = 32/85 (37%), Positives = 46/85 (53%), Gaps = 1/85 (1%)
Query: 281 EDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGH 340
E G+DVN D+ T LH AA+N I+ + GA V+ ++ TPL A+ GH
Sbjct: 66 ESGWDVNQPDSETVTLLHWAAINNRRDIIRYFLEKGATVDAVGGELNA-TPLHWATRQGH 124
Query: 341 INVVKYLLDHGADPTMVNAKGLSAI 365
+ V L+ GADP + +A+G S I
Sbjct: 125 LGAVVLLMAAGADPRIRDAEGCSCI 149
>SPBP16F5.05c [R] KOG0504 FOG: Ankyrin repeat
Length = 146
Score = 53.5 bits (127), Expect = 2e-06
Identities = 34/114 (29%), Positives = 59/114 (50%), Gaps = 4/114 (3%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
AC +L ++IE+ +++ +D GN+ LH A+ NGH A+V+ ++ I + +
Sbjct: 9 ACRAADEELLDEIIEKCPQELSRRDENGNSGLHMASANGHIAVVQKIIPYLNKEVINAQN 68
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDR 379
+T + A+ NGH + K LL+ G DP + N S I E+D+ N +
Sbjct: 69 ESGNTAMHWAALNGHAEICKLLLEAGGDPHIKNIYEKSPI----YEADIRNQQK 118
Score = 51.2 bits (121), Expect = 8e-06
Identities = 31/96 (32%), Positives = 53/96 (54%), Gaps = 3/96 (3%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDV-NDQDNAGNTPLHEAALNGHSAIVELLV 313
RD G + L +A G + +K+I +V N Q+ +GNT +H AALNGH+ I +LL+
Sbjct: 32 RDENGNSGLHMASANGHIAVVQKIIPYLNKEVINAQNESGNTAMHWAALNGHAEICKLLL 91
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLD 349
G + +I+ +++ +P+ +A V+ LD
Sbjct: 92 EAGGDPHIK--NIYEKSPIYEADIRNQQKVMDLFLD 125
>SPAC6C3.08 [O] KOG4412 26S proteasome regulatory complex subunit PSMD10
Length = 234
Score = 53.5 bits (127), Expect = 2e-06
Identities = 36/109 (33%), Positives = 57/109 (52%), Gaps = 2/109 (1%)
Query: 258 GGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGA 317
GG+T L A KG+ + + L ++ + +D G TPLH AA G +V+ L+ A
Sbjct: 106 GGQTCLHYAAGKGRLSIVQLLCDKAPELIRKKDLQGQTPLHRAAAVGKIQVVKYLISQRA 165
Query: 318 NVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIE 366
+N + D + TPL A A GH +V L+ GAD +++ +A+E
Sbjct: 166 PLN--TSDSYGFTPLHFALAEGHPDVGVELVRAGADTLRKDSENHTALE 212
>Hs4885643 [D] KOG0515 p53-interacting protein 53BP/ASPP contains ankyrin and
SH3 domains
Length = 1005
Score = 53.5 bits (127), Expect = 2e-06
Identities = 43/120 (35%), Positives = 66/120 (54%), Gaps = 16/120 (13%)
Query: 243 GKKIPKTKRGVHRDAGG-RTK---LQIACD---KGKYDLAKKLIEEDGYDVNDQ---DNA 292
GK+ K G R A G R K L + D +G++DL +++I Y+V+D ++
Sbjct: 780 GKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRII----YEVDDPSLPNDE 835
Query: 293 GNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGA 352
G T LH A GH+ IV+ LV+ G NVN D + TPL A++ ++ V K+L++ GA
Sbjct: 836 GITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGW--TPLHCAASCNNVQVCKFLVESGA 893
>Hs22057484 [R] KOG0504 FOG: Ankyrin repeat
Length = 324
Score = 53.5 bits (127), Expect = 2e-06
Identities = 27/61 (44%), Positives = 39/61 (63%), Gaps = 1/61 (1%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
RD GRT L +AC++G D + L++ G D D+AGN+P+ AA GH A++E LVR
Sbjct: 80 RDERGRTALSLACERGHLDAVQLLVQFSG-DPEAADSAGNSPVMWAAACGHGAVLEFLVR 138
Query: 315 N 315
+
Sbjct: 139 S 139
>Hs21450703 [R] KOG0504 FOG: Ankyrin repeat
Length = 258
Score = 53.5 bits (127), Expect = 2e-06
Identities = 34/108 (31%), Positives = 52/108 (47%), Gaps = 6/108 (5%)
Query: 435 LGKNKLLKASKEGKLAYVGSYLENGGRPDFRCFLE------SCIYGHDDVVSLFLAFGAQ 488
+G LKA+ E + + YL +GG P+ L +C+ GH +V+ L GA
Sbjct: 110 VGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGAT 169
Query: 489 VNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTALHYA 536
V+ + +TP+ + GH+ ++K LL GA DK T LH A
Sbjct: 170 VDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVA 217
Score = 52.0 bits (123), Expect = 4e-06
Identities = 37/98 (37%), Positives = 52/98 (52%), Gaps = 7/98 (7%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L+ A + +Y + K L DG D N D T LH A L GHS +V L+ GA V+ +
Sbjct: 116 LKAAAENQEYLIDKYLT--DGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDAR 173
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAK 360
D+ TP+ A GH+ ++K LL+ GA VNA+
Sbjct: 174 --DLLDRTPVFWACRGGHLVILKQLLNQGA---RVNAR 206
>Hs20562143 [R] KOG0504 FOG: Ankyrin repeat
Length = 583
Score = 53.5 bits (127), Expect = 2e-06
Identities = 34/106 (32%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G+T L +A G +A L+++ G ++ +D G T L GH +V L+ +GAN
Sbjct: 29 GQTPLMLASSCGNESIAYFLLQQ-GAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGAN 87
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSA 364
N++ + TPL++A+A GH +V+Y L+HG + G +A
Sbjct: 88 ANVRE-PICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATA 132
Score = 50.8 bits (120), Expect = 1e-05
Identities = 26/62 (41%), Positives = 37/62 (58%)
Query: 474 GHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGADPQKTDKRKKTAL 533
GHD +V L L G VN+ EGQTPLML+ G+ ++ LL+ GA+ + D + TAL
Sbjct: 7 GHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTAL 66
Query: 534 HY 535
+
Sbjct: 67 FH 68
>Hs18570215 [R] KOG0508 Ankyrin repeat protein
Length = 228
Score = 53.5 bits (127), Expect = 2e-06
Identities = 38/152 (25%), Positives = 74/152 (48%), Gaps = 11/152 (7%)
Query: 266 ACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYD 325
AC G ++ +K+L+E G+D N +D+ G T LH AA G+ I +LL + GA++ Y
Sbjct: 19 ACIDGDFNYSKRLLES-GFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQ 77
Query: 326 MFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDM 385
L GH++ +++L+ +G + N +G + + + + ++ D R++ +
Sbjct: 78 GNTALHLC-----GHVDTIQFLVSNGLKIDICNHQGATPL-VLAKRRGVNKDVIRLLESL 131
Query: 386 KDM----LKRATRKYIKHSHRTLQSSSMSRHS 413
++ R T ++ S+M HS
Sbjct: 132 EEQEVKGFNRGTHSKLETMQTAESESAMESHS 163
>Hs18254476 [R] KOG0504 FOG: Ankyrin repeat
Length = 329
Score = 53.5 bits (127), Expect = 2e-06
Identities = 68/263 (25%), Positives = 106/263 (39%), Gaps = 43/263 (16%)
Query: 260 RTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANV 319
R+ L A +G+ LA + + GY+VN TPLHEA L H A L+ GANV
Sbjct: 71 RSPLHEAASQGRL-LALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANV 129
Query: 320 NIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDR 379
N + D TPL +A + G + + LL++GA A+ S + S E+
Sbjct: 130 NAITIDGV--TPLFNACSQGSPSCAELLLEYGA-----KAQLESCLPSPTHEAASKGH-- 180
Query: 380 RIVHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNK 439
H+ D+L D+D+++ H + S+
Sbjct: 181 ---HECLDIL--------------------ISWGIDVDQEIPHLGTPLYVACMSQ----- 212
Query: 440 LLKASKEGKLAYVGSYLENGGRPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTP 499
+ KL Y G+ ++ G D + ++V+L L FGA +N N E P
Sbjct: 213 --QFHCIWKLLYAGADVQKGKYWDTPLH-AAAQQSSTEIVNLLLEFGADINAKNTELLRP 269
Query: 500 LMLSVGRGHVNVVKLLLEAGADP 522
+ V V ++LL+ A P
Sbjct: 270 --IDVATSSSMVERILLQHEATP 290
>At3g58760 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 456
Score = 53.5 bits (127), Expect = 2e-06
Identities = 38/110 (34%), Positives = 58/110 (52%), Gaps = 3/110 (2%)
Query: 262 KLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNI 321
+L ++G D K+++ G +V+ +D T LH AA G + +VELL+ GA V+
Sbjct: 52 RLMYLANEGDIDGINKMLDS-GTNVDYRDIDARTALHVAACQGRTDVVELLLSRGAKVDT 110
Query: 322 QSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEE 371
+ D + TPL DA + +V+K L HGA PT+ L+ E E E
Sbjct: 111 K--DRWGSTPLADAVYYKNHDVIKLLEKHGAKPTIAPMHVLTDKEVPEYE 158
>SPAPB1E7.05_1 [R] KOG0504 FOG: Ankyrin repeat
Length = 724
Score = 53.5 bits (127), Expect = 2e-06
Identities = 47/160 (29%), Positives = 74/160 (45%), Gaps = 7/160 (4%)
Query: 263 LQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQ 322
L + C G YDL + + G++ N+ D + NT LH A V++L++ GAN + +
Sbjct: 337 LVLTCCVGDYDLIVEELILAGFNPNEVDASSNTALHTAVRYNRPECVKMLLKLGANPSAR 396
Query: 323 SYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDR-RI 381
+ + TPL+ ASA G +V L+ GA V++ G +A+E + D+ R
Sbjct: 397 DF-LNSWTPLMLASATGLSEIVSILVASGASVDEVDSSGWTAMEQAVVRGYLHLADKLRT 455
Query: 382 VHDMKDMLKRATRKYIKHSHRTLQSSSMSRHSDDIDKQLN 421
+ D YIK S SS M +D QL+
Sbjct: 456 QVALSDKPVNLHTLYIKAS-----SSEMRSRKRAMDLQLS 490
>HsM13376093 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 825
Score = 53.1 bits (126), Expect = 2e-06
Identities = 32/73 (43%), Positives = 43/73 (58%), Gaps = 4/73 (5%)
Query: 282 DGYDVNDQDNAGN--TPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANG 339
DG D N + N +PLH AA GH I +LV+ GAN++ S D TPL++A+ N
Sbjct: 729 DGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQ--RTPLMEAAENN 786
Query: 340 HINVVKYLLDHGA 352
H+ VKYL+ GA
Sbjct: 787 HLEAVKYLIKAGA 799
>Hs18254462 [R] KOG0504 FOG: Ankyrin repeat
Length = 453
Score = 53.1 bits (126), Expect = 2e-06
Identities = 38/120 (31%), Positives = 60/120 (49%), Gaps = 4/120 (3%)
Query: 250 KRGVHRDA--GGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSA 307
++G DA GGR L AC + ++D + L+ G N G TPLH +
Sbjct: 132 RQGAELDARVGGRAALHEACARAQFDCVRLLLTF-GAKANVLTEEGTTPLHLCTIPESLQ 190
Query: 308 IVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIES 367
+LL+ GA VN+ + + +TPL A+A G V L+HGAD + ++G +A+ +
Sbjct: 191 CAKLLLEAGATVNLAAGES-QETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNA 249
>At1g05640 [R] KOG0504 FOG: Ankyrin repeat
Length = 627
Score = 53.1 bits (126), Expect = 2e-06
Identities = 78/350 (22%), Positives = 140/350 (39%), Gaps = 76/350 (21%)
Query: 223 KRKSSSIENSSNHKKQKHSAGKKIPKTKRGVHRDAGGRTKLQIACDKGKYDLAKKLIE-- 280
+R+ S + KK+ S GK+ G + L +A G +LI
Sbjct: 90 ERQLSFMNVGGERKKKTDSPGKR-------------GDSPLHLAARTGNLGKVMELIRAC 136
Query: 281 ---EDGYDVNDQDNA-GNTPLHEAALNGHSAIVELLVRNG--ANVNIQSYDMFLDTPLID 334
E+ +++ + N G TPL+ AA NGHS +VE ++++ ++++ + F P
Sbjct: 137 NGIEELKELSSKQNLEGETPLYSAAENGHSLVVEEMLKHMDLDTASVKARNGF--DPFHV 194
Query: 335 ASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATR 394
A+ GHI +K LL+ P + LS +
Sbjct: 195 AAKQGHIEALKKLLE--TFPNLAMTVDLSCTTA--------------------------- 225
Query: 395 KYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGS 454
L +++ H+D ++ L D + I+ GK L A++ G V S
Sbjct: 226 ---------LHTAASQGHTDVVNLLLKTDS--HLAKIAKNNGKTALHSAARMGHREVVKS 274
Query: 455 YLENGGRPDFR------CFLESCIYGHDD--VVSLFLAFGAQVNMSNKEGQTPLMLSVGR 506
+ N FR L + G ++ V+ L A +++ + +G TPL + +
Sbjct: 275 LIGNDASIGFRTDKKGQTALHMAVKGQNEGIVLELVKPDPAILSVEDSKGNTPLHTATNK 334
Query: 507 GHVNVVKLLLE-AGADPQKTDKRKKTALHYANHSSLGLTDPDEVNLLKAA 555
G + +V+ L+ G + +K TAL A + +P+ V++LK A
Sbjct: 335 GRIKIVRCLVSFDGINLNAMNKAGDTALDIAEK----IGNPELVSVLKEA 380
>7295029 [R] KOG0510 Ankyrin repeat protein
Length = 1274
Score = 53.1 bits (126), Expect = 2e-06
Identities = 46/164 (28%), Positives = 83/164 (50%), Gaps = 10/164 (6%)
Query: 286 VNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVK 345
+N++D+ G +PLH A+ +GH +E L+R GA +N+++ + ++PL A+ G N V+
Sbjct: 457 LNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNN--ESPLHFAARYGRYNTVR 514
Query: 346 YLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHRT-L 404
LLD ++N + + + S + R+V + +L R + H+ R L
Sbjct: 515 QLLDSEKGSFIINESDGAGMTPLHISSQQGH--TRVV---QLLLNRGALLHRDHTGRNPL 569
Query: 405 QSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGK 448
Q ++MS +++ I +L H + D K G L A+ E K
Sbjct: 570 QLAAMSGYTETI--ELLHSVHSHLLDQVDKDGNTALHLATMENK 611
>SPCP1E11.10 [R] KOG0504 FOG: Ankyrin repeat
Length = 207
Score = 52.8 bits (125), Expect = 3e-06
Identities = 36/110 (32%), Positives = 56/110 (50%), Gaps = 7/110 (6%)
Query: 265 IACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSY 324
IA GK D+ K ++ G N D G TP+H A GHS ++++LV G ++NI+
Sbjct: 10 IAASDGKTDVVLKHLDS-GISPNAADENGYTPIHAAVSYGHSDLLKILVERGGDINIRDQ 68
Query: 325 DMFLDTPLIDASANGHINVVKYLLD-HGADPTMVNAKGLSAIESIEEESD 373
D +TPL + + L++ + AD T+ N GL A + IE +
Sbjct: 69 DG--ETPLFVCE---KLEIAHDLINQYNADTTVKNNDGLIAAQVIEANGE 113
>Hs18426879 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1176
Score = 52.8 bits (125), Expect = 3e-06
Identities = 37/120 (30%), Positives = 62/120 (50%), Gaps = 3/120 (2%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+D+GG T + A + ++ + L+ G DV DN N LH A+ G +AI E+L+
Sbjct: 747 QDSGGWTPIIWAAEHKHIEVIRMLLTR-GADVTLTDNEENICLHWASFTGSAAIAEVLLN 805
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDM 374
A ++ + + DTPL A+ + + V L GA+P + N +G +A + E SD+
Sbjct: 806 --ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 863
Score = 50.8 bits (120), Expect = 1e-05
Identities = 34/103 (33%), Positives = 56/103 (54%), Gaps = 2/103 (1%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D RT L A ++A+ +++ G V ++ G+T LH AA G+ +V LL+
Sbjct: 681 DKQQRTPLMEAVVNNHLEVARYMVQRGGC-VYSKEEDGSTCLHHAAKIGNLEMVSLLLST 739
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVN 358
G V++ + D TP+I A+ + HI V++ LL GAD T+ +
Sbjct: 740 G-QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTD 781
>Hs18375637 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1210
Score = 52.8 bits (125), Expect = 3e-06
Identities = 37/120 (30%), Positives = 62/120 (50%), Gaps = 3/120 (2%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+D+GG T + A + ++ + L+ G DV DN N LH A+ G +AI E+L+
Sbjct: 781 QDSGGWTPIIWAAEHKHIEVIRMLLTR-GADVTLTDNEENICLHWASFTGSAAIAEVLLN 839
Query: 315 NGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESDM 374
A ++ + + DTPL A+ + + V L GA+P + N +G +A + E SD+
Sbjct: 840 --ARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDV 897
Score = 50.8 bits (120), Expect = 1e-05
Identities = 34/103 (33%), Positives = 56/103 (54%), Gaps = 2/103 (1%)
Query: 256 DAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRN 315
D RT L A ++A+ +++ G V ++ G+T LH AA G+ +V LL+
Sbjct: 715 DKQQRTPLMEAVVNNHLEVARYMVQRGGC-VYSKEEDGSTCLHHAAKIGNLEMVSLLLST 773
Query: 316 GANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVN 358
G V++ + D TP+I A+ + HI V++ LL GAD T+ +
Sbjct: 774 G-QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTD 815
>CE19706 [T] KOG0195 Integrin-linked kinase
Length = 466
Score = 52.8 bits (125), Expect = 3e-06
Identities = 33/87 (37%), Positives = 49/87 (55%), Gaps = 2/87 (2%)
Query: 279 IEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASAN 338
+++ +D+N D+ + LH AA GH AI E+L+ GA VN S +M DT L A+A+
Sbjct: 37 LDDHEHDLNVGDDHAFSLLHWAAKGGHVAIAEMLLSRGARVN--STNMGDDTSLHLAAAH 94
Query: 339 GHINVVKYLLDHGADPTMVNAKGLSAI 365
GH +V LL AD N G++ +
Sbjct: 95 GHRQIVVKLLSRKADVNATNEHGMTPL 121
>At5g53470 [I] KOG0817 Acyl-CoA-binding protein
Length = 338
Score = 52.8 bits (125), Expect = 3e-06
Identities = 28/71 (39%), Positives = 43/71 (60%), Gaps = 1/71 (1%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
RD+ GRT L A D+G ++A+ L++++ DVN +DN G T LH A + A+ E LV+
Sbjct: 247 RDSEGRTPLHWAIDRGHLNVAEALVDKNA-DVNAKDNEGQTSLHYAVVCEREALAEFLVK 305
Query: 315 NGANVNIQSYD 325
A+ I+ D
Sbjct: 306 QKADTTIKDED 316
>Hs18254470 [R] KOG0504 FOG: Ankyrin repeat
Length = 429
Score = 52.4 bits (124), Expect = 3e-06
Identities = 40/104 (38%), Positives = 50/104 (47%), Gaps = 2/104 (1%)
Query: 258 GGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGA 317
GGRT L AC G L+ G D N D G PLH G ELL+R GA
Sbjct: 147 GGRTALHEACAAGHTACVHVLLVA-GADPNIADQDGKRPLHLCRGPGTLECAELLLRFGA 205
Query: 318 NVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKG 361
V+ +S + +TPL A+ GH+ + LL GA P NA+G
Sbjct: 206 RVDGRSEEEE-ETPLHVAARLGHVELADLLLRRGACPDARNAEG 248
>CE27420 [R] KOG0504 FOG: Ankyrin repeat
Length = 510
Score = 52.4 bits (124), Expect = 3e-06
Identities = 39/129 (30%), Positives = 67/129 (51%), Gaps = 17/129 (13%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDV-----NDQDNAGNTPLHEAALNGHSAIVELLV 313
G++ L IAC G + + ++ G D ND+ NA +H AA +G ++ L+
Sbjct: 241 GQSLLHIACLCGHEHIVRWILNRSGSDAILWTTNDRANA----IHCAAYSGSVPVLSHLL 296
Query: 314 RNGANVNIQSYDMFL-----DTPLIDASANGHINVVKYLLDHGADPTMVNAKGLS--AIE 366
N + + Y M L +TPL A+ N H++ Y+L++GADP ++NA G S +I
Sbjct: 297 -NAFSKKKRHYVMTLRDTRGNTPLHLAAMNNHLDAALYMLENGADPALINANGHSPQSIA 355
Query: 367 SIEEESDMD 375
++ +M+
Sbjct: 356 ALRHHREME 364
>Hs7706379 [R] KOG0504 FOG: Ankyrin repeat
Length = 426
Score = 52.0 bits (123), Expect = 4e-06
Identities = 33/101 (32%), Positives = 51/101 (49%), Gaps = 1/101 (0%)
Query: 259 GRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGAN 318
G+T L +AC+ D K L + G +N +G+T LH + LV GAN
Sbjct: 107 GKTPLHVACEMANVDCVKILCDR-GAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGAN 165
Query: 319 VNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNA 359
VN+++ + +TPL A+ G +V + ++HGA VNA
Sbjct: 166 VNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNA 206
>Hs4557799 [T] KOG1217 Fibrillins and related proteins containing Ca2+-binding
EGF-like domains
Length = 2321
Score = 52.0 bits (123), Expect = 4e-06
Identities = 36/114 (31%), Positives = 57/114 (49%), Gaps = 2/114 (1%)
Query: 252 GVHRDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVEL 311
G D G T L +A + D AK+L++ G D N QD++G TPLH A + ++
Sbjct: 1832 GARTDRTGETALHLAARYARADAAKRLLDA-GADTNAQDHSGRTPLHTAVTADAQGVFQI 1890
Query: 312 LVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAI 365
L+RN + ++ + T LI A+ +V+ L+ AD V+ G SA+
Sbjct: 1891 LIRN-RSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSAL 1943
>7296976 [M] KOG4177 Ankyrin
Length = 599
Score = 52.0 bits (123), Expect = 4e-06
Identities = 74/316 (23%), Positives = 135/316 (42%), Gaps = 46/316 (14%)
Query: 241 SAGKKIPKTKRGVHRDA---GGR---TKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGN 294
SA + +T G D GG+ T L IA D ++ + G N +
Sbjct: 185 SAKPAVVETLLGFGADVHVRGGKLRETPLHIAARVKDGDRCALMLLKSGASPNLTTDDCL 244
Query: 295 TPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLD----- 349
TP+H AA +G+ A + L+ + + +S +TPL A H ++V++L++
Sbjct: 245 TPVHVAARHGNLATLMQLLEDEGDPLYKSNTG--ETPLHMACRACHPDIVRHLIETVKEK 302
Query: 350 HGADPTM-----VNAKGLSAI----ESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHS 400
HG D VN G +A+ + +EE + D++IV + + T +
Sbjct: 303 HGPDKATTYINSVNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTAL 362
Query: 401 HRTLQSSSMSRHSDDIDKQLNHDDDFYWTDISSKLGKNKLLKASKEGKLAYVGSYLENGG 460
+++ ++D + + ++H + TDI + + + G
Sbjct: 363 ETAFHYCAVAGNNDVLMEMISHMNP---TDIQKAMNRQSSV-----------------GW 402
Query: 461 RPDFRCFLESCIYGHDDVVSLFLAFGAQVNMSNKEGQTPLMLSVGRGHVNVVKLLLEAGA 520
P L +C GH ++V+ LA A+V++ + EG++ L L+ RG+++V LL A
Sbjct: 403 TP----LLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLAAERGYLHVCDALLTNKA 458
Query: 521 DPQKTDKRKKTALHYA 536
+ +TALH A
Sbjct: 459 FINSKSRVGRTALHLA 474
>7294864 [R] KOG0504 FOG: Ankyrin repeat
Length = 358
Score = 52.0 bits (123), Expect = 4e-06
Identities = 74/286 (25%), Positives = 109/286 (37%), Gaps = 45/286 (15%)
Query: 149 PTEPASPPRPKMGRLIRGDQLE---------SGNNSRQSSAPVLTNDGEXXXXXXX---- 195
P PA PP P G+ S N S +S + + GE
Sbjct: 54 PPPPAMPPTPTSSPNTHGEWPHMNINLNLNMSSNPSTNASFQLSRDRGEHFALPHLPPLP 113
Query: 196 -XXEARTAKISSSAIHEDSSPVKHYNEHKRKSSSIENSSNHKKQKHSAGKKIPKTKRGVH 254
A A+ S IH + P S S + ++ KHS +
Sbjct: 114 LNPNASNAEYLPSLIHPSTLP--------SGSKSFKMRPRMQRLKHSYSYS------NII 159
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVR 314
+ GR KL+ A +L +++E G + N D +PLH AA G+ IV+ L++
Sbjct: 160 VQSNGR-KLRTAASTCNIELLNRILE-GGANPNAADEYNRSPLHLAACRGYIPIVQQLLK 217
Query: 315 NGANVNIQSYDMFLDTPL----IDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEE 370
GAN N+ D +TPL I AS+N VV LL GA M + S +E E
Sbjct: 218 YGANPNV--VDSLGNTPLHLAVISASSNNFNVVVGVLLQGGASVHMYDRSNKSPLELAEA 275
Query: 371 ESDM--------DNDDRRIVHDMKDMLKRATRKYIKHSHRTLQSSS 408
+ + + +I+ DM ML +Y+ R L+ S
Sbjct: 276 KLRLLRNRYDHPTPETAKILEDM-CMLTTLILRYMVKQQRELEDLS 320
>7293542 [K] KOG4214 Myotrophin and similar proteins
Length = 124
Score = 52.0 bits (123), Expect = 4e-06
Identities = 37/102 (36%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Query: 270 GKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLD 329
G YD +++ +VNDQ PLH AA G ++E VR GA V+ + D +
Sbjct: 17 GVYDEVERIFLAGSLNVNDQMGV-RFPLHYAADFGQLKLLEFFVRIGAEVDRK--DKYGI 73
Query: 330 TPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEE 371
TPL+ A GH V++LL GA T +G S E+ E+E
Sbjct: 74 TPLLAAIWEGHTRCVEFLLRMGASRTERTPEGQSYAEAAEQE 115
>Hs4885087 [R] KOG0504 FOG: Ankyrin repeat
Length = 446
Score = 50.8 bits (120), Expect = 1e-05
Identities = 55/192 (28%), Positives = 90/192 (46%), Gaps = 33/192 (17%)
Query: 255 RDAGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQD-NAGNTPLHEAALNGHSAIVELLV 313
R+ G T L +A + + + L+E G D++ D +G +PL A N ++V+LL+
Sbjct: 230 RNYDGLTALHVAVNTECQETVQLLLER-GADIDAVDIKSGRSPLIHAVENNSLSMVQLLL 288
Query: 314 RNGANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGADPTMVNAKGLSAIESIEEESD 373
++GANVN Q Y + L AS G + +V+ L+ GAD ++ N + +
Sbjct: 289 QHGANVNAQMYSG--SSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPL-------- 338
Query: 374 MDNDDRRIVHDMKDMLK-RATRKYIKHSHRTLQSSSMSRHSDDIDKQLNHDDDFYWTDIS 432
M RR++ D+L+ +ATR +S S+ D+ N + S
Sbjct: 339 MVARSRRVI----DILRGKATR-----------PASTSQPDPSPDRSANTS-----PESS 378
Query: 433 SKLGKNKLLKAS 444
S+L N LL AS
Sbjct: 379 SRLSSNGLLSAS 390
>Hs22044723 [R] KOG0504 FOG: Ankyrin repeat
Length = 119
Score = 50.8 bits (120), Expect = 1e-05
Identities = 39/97 (40%), Positives = 50/97 (51%), Gaps = 3/97 (3%)
Query: 257 AGGRTKLQIACDKGKYDLAKKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNG 316
A T L +A KG Y + K I + +VN D GNT L A+ GH+ IV+ L+ G
Sbjct: 10 ANSMTALIVAV-KGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAG 68
Query: 317 ANVNIQSYDMFLDTPLIDASANGHINVVKYLLDHGAD 353
VNI D DT LI A GH+ +V+ LL AD
Sbjct: 69 TYVNIP--DRSGDTVLIGAVRGGHVEIVRALLQKYAD 103
>CE17314 [K] KOG1015 Transcription regulator XNP/ATRX DEAD-box superfamily
Length = 1359
Score = 50.8 bits (120), Expect = 1e-05
Identities = 51/233 (21%), Positives = 97/233 (40%), Gaps = 8/233 (3%)
Query: 52 KEEEVSQKV-TSTDQNSTKQPSDEPYVVSQANSSDQKVGSPLNNQESIPVRQAETKGPIN 110
KE+ V ++ TS + + ++PS + + + + + +E ++ K
Sbjct: 172 KEKSVKKRAETSEESDEDEKPSKKSKKGLKKKAKSESESESEDEKEVKKSKKKSKKVVKK 231
Query: 111 EIKQETDVEEKKNLPKVGRNKHSDEEYSSALSEVESDAPTEPASPPRPKMGRLIRGDQLE 170
E + E + EKK K R+K S EE S+ SE + E S P+PK + + +L
Sbjct: 232 ESESEDEAPEKKKTEKRKRSKTSSEE--SSESEKSDEEEEEKESSPKPKKKKPLAVKKLS 289
Query: 171 SGNNSRQSSAPVLTNDGE----XXXXXXXXXEARTAKISSSAIHEDSSPVKHYNEHKRKS 226
S S +S VL + + + ++ +S + E S K + +S
Sbjct: 290 SDEESEESDVEVLPQKKKRGAVTLISDSEDEKDQKSESEASDVEEKVSKKKAKKQESSES 349
Query: 227 SSIENSSNHKKQKHSAGKKIP-KTKRGVHRDAGGRTKLQIACDKGKYDLAKKL 278
S + + + S K+ P K K+G+ D+ K I ++ + + K+L
Sbjct: 350 GSDSSEGSITVNRKSKKKEKPEKKKKGIIMDSSKLQKETIDAERAEKERRKRL 402
>At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 438
Score = 50.8 bits (120), Expect = 1e-05
Identities = 30/76 (39%), Positives = 45/76 (58%), Gaps = 2/76 (2%)
Query: 276 KKLIEEDGYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDA 335
+KL+EED V+ +D TPLH A+L+G +V+ L+ GA+VN Q D + +TPL DA
Sbjct: 54 RKLLEEDPTLVHARDYDKRTPLHVASLHGWIDVVKCLLEFGADVNAQ--DRWKNTPLADA 111
Query: 336 SANGHINVVKYLLDHG 351
+++ L HG
Sbjct: 112 EGARKQKMIELLKSHG 127
>At1g07710 [R] KOG0504 FOG: Ankyrin repeat
Length = 543
Score = 50.8 bits (120), Expect = 1e-05
Identities = 54/199 (27%), Positives = 86/199 (43%), Gaps = 18/199 (9%)
Query: 233 SNHKKQKHSAGK----KIPKTKRG------VHRDAGGRTKLQIACDKGKYDLAKKLIEED 282
SN K HSA + K+ K + D G+T L +A ++ ++LI+ D
Sbjct: 167 SNGKTALHSASRNGHVKVIKALLASEPAIAIRMDKKGQTALHMAVKGTNVEVVEELIKAD 226
Query: 283 GYDVNDQDNAGNTPLHEAALNGHSAIVELLVRNGANVNIQSYDMFLDTPLIDASANGHIN 342
+N D GNT LH AA G S IV+LL+ N + ++ + +T L A G+
Sbjct: 227 RSSINIADTKGNTALHIAARKGRSQIVKLLLANNM-TDTKAVNRSGETALDTAEKIGNPE 285
Query: 343 VVKYLLDHGADPTMVNAKGLSAIESIEEESDMDNDDRRIVHDMKDMLKRATRKYIKHSHR 402
V L HG P+ K S E +D + VH+ + R TRK ++ +
Sbjct: 286 VALILQKHGV-PSAKTIKP-SGPNPARELKQTVSDIKHEVHNQLEH-TRLTRKRVQGIAK 342
Query: 403 TLQSSSMSRHSDDIDKQLN 421
L H++ ++ +N
Sbjct: 343 QLN----KMHTEGLNNAIN 357
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.310 0.129 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,924,723
Number of Sequences: 60738
Number of extensions: 2227930
Number of successful extensions: 12279
Number of sequences better than 1.0e-05: 162
Number of HSP's better than 0.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 9609
Number of HSP's gapped (non-prelim): 1479
length of query: 960
length of database: 30,389,216
effective HSP length: 116
effective length of query: 844
effective length of database: 23,343,608
effective search space: 19702005152
effective search space used: 19702005152
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)