ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI1219 check: MH Q KOG1209 Secondary metabolites biosynthesis, transport and catabolism 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI1219 428927 428013 -305
(305 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase ... 323 2e-88
SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reduct... 126 3e-29
At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductas... 104 1e-22
CE27259 [R] KOG0725 Reductases with broad range of substrate spe... 83 6e-16
CE27260 [R] KOG0725 Reductases with broad range of substrate spe... 82 1e-15
CE21093 [R] KOG0725 Reductases with broad range of substrate spe... 80 3e-15
At3g55310 [R] KOG0725 Reductases with broad range of substrate s... 78 1e-14
7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 76 5e-14
Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 76 7e-14
Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 75 2e-13
YMR226c [Q] KOG1205 Predicted dehydrogenase 74 2e-13
CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 74 2e-13
7296705 [R] KOG0725 Reductases with broad range of substrate spe... 74 2e-13
At1g07440 [R] KOG0725 Reductases with broad range of substrate s... 74 3e-13
7290108 [R] KOG0725 Reductases with broad range of substrate spe... 73 4e-13
At3g03330 [Q] KOG1205 Predicted dehydrogenase 73 6e-13
At1g63380 [R] KOG0725 Reductases with broad range of substrate s... 73 6e-13
Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 72 1e-12
At2g29350 [R] KOG0725 Reductases with broad range of substrate s... 72 1e-12
CE07539 [Q] KOG1205 Predicted dehydrogenase 71 2e-12
7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 71 2e-12
YBR159w [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 71 2e-12
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 70 3e-12
At3g46170 [R] KOG0725 Reductases with broad range of substrate s... 70 3e-12
At2g29260 [R] KOG0725 Reductases with broad range of substrate s... 70 3e-12
At5g04900 [R] KOG0725 Reductases with broad range of substrate s... 70 4e-12
HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 70 5e-12
7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 70 5e-12
7296047 [Q] KOG1205 Predicted dehydrogenase 69 6e-12
Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 69 8e-12
At5g06060 [R] KOG0725 Reductases with broad range of substrate s... 69 8e-12
At2g29170 [R] KOG0725 Reductases with broad range of substrate s... 69 8e-12
CE07544 [Q] KOG1205 Predicted dehydrogenase 69 1e-11
CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 69 1e-11
CE15574 [R] KOG0725 Reductases with broad range of substrate spe... 68 2e-11
At1g62610 [R] KOG0725 Reductases with broad range of substrate s... 68 2e-11
Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 67 2e-11
Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 67 2e-11
At2g29340 [R] KOG0725 Reductases with broad range of substrate s... 67 2e-11
At2g29290 [R] KOG0725 Reductases with broad range of substrate s... 67 2e-11
7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 67 3e-11
SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 66 5e-11
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 66 5e-11
At2g29150 [R] KOG0725 Reductases with broad range of substrate s... 66 5e-11
Hs7706318 [Q] KOG1205 Predicted dehydrogenase 66 7e-11
7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 66 7e-11
CE26808_2 [R] KOG0725 Reductases with broad range of substrate s... 66 7e-11
At3g47360 [Q] KOG1205 Predicted dehydrogenase 65 9e-11
At2g30670 [R] KOG0725 Reductases with broad range of substrate s... 65 9e-11
7301818 [Q] KOG1205 Predicted dehydrogenase 65 9e-11
Hs5031737 [R] KOG0725 Reductases with broad range of substrate s... 65 1e-10
7296704 [R] KOG0725 Reductases with broad range of substrate spe... 65 1e-10
7295487 [R] KOG0725 Reductases with broad range of substrate spe... 65 1e-10
YIR036c [Q] KOG1204 Predicted dehydrogenase 65 2e-10
SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase 65 2e-10
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 65 2e-10
At4g03140 [R] KOG0725 Reductases with broad range of substrate s... 65 2e-10
At3g26770 [R] KOG0725 Reductases with broad range of substrate s... 65 2e-10
At2g29330 [R] KOG0725 Reductases with broad range of substrate s... 65 2e-10
At2g29310 [R] KOG0725 Reductases with broad range of substrate s... 65 2e-10
At1g10310 [R] KOG0725 Reductases with broad range of substrate s... 65 2e-10
Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 64 2e-10
CE12594 [R] KOG0725 Reductases with broad range of substrate spe... 64 2e-10
7290988 [Q] KOG1205 Predicted dehydrogenase 64 2e-10
SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase 64 3e-10
Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 64 3e-10
CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 64 3e-10
CE12990 [R] KOG0725 Reductases with broad range of substrate spe... 63 5e-10
CE11498 [R] KOG0725 Reductases with broad range of substrate spe... 63 5e-10
At4g13180 [R] KOG0725 Reductases with broad range of substrate s... 63 5e-10
At5g50690 [Q] KOG1205 Predicted dehydrogenase 63 6e-10
At5g50590 [Q] KOG1205 Predicted dehydrogenase 63 6e-10
At3g47350 [Q] KOG1205 Predicted dehydrogenase 63 6e-10
At2g29360 [R] KOG0725 Reductases with broad range of substrate s... 63 6e-10
CE21092 [R] KOG0725 Reductases with broad range of substrate spe... 62 8e-10
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 62 8e-10
At2g29370 [R] KOG0725 Reductases with broad range of substrate s... 62 8e-10
At2g29320 [R] KOG0725 Reductases with broad range of substrate s... 62 8e-10
SPCC24B10.20 [R] KOG1611 Predicted short chain-type dehydrogenase 62 1e-09
SPAC977.08 [Q] KOG1205 Predicted dehydrogenase 62 1e-09
SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase 62 1e-09
CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 62 1e-09
CE05726 [R] KOG0725 Reductases with broad range of substrate spe... 62 1e-09
At3g42960 [R] KOG0725 Reductases with broad range of substrate s... 62 1e-09
At2g29300 [R] KOG0725 Reductases with broad range of substrate s... 62 1e-09
CE20725 [R] KOG0725 Reductases with broad range of substrate spe... 60 3e-09
CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 60 3e-09
Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase 60 4e-09
Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 60 5e-09
Hs20149619 [Q] KOG1205 Predicted dehydrogenase 59 7e-09
At5g50700 [Q] KOG1205 Predicted dehydrogenase 59 7e-09
At5g50600 [Q] KOG1205 Predicted dehydrogenase 59 7e-09
At3g29250 [R] KOG0725 Reductases with broad range of substrate s... 59 7e-09
7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 59 7e-09
Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 59 1e-08
Hs10337605 [R] KOG0725 Reductases with broad range of substrate ... 59 1e-08
CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase 59 1e-08
At2g47130 [R] KOG0725 Reductases with broad range of substrate s... 59 1e-08
At1g07450 [R] KOG0725 Reductases with broad range of substrate s... 59 1e-08
7295621 [Q] KOG1205 Predicted dehydrogenase 59 1e-08
7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 58 1e-08
7296706_2 [R] KOG0725 Reductases with broad range of substrate s... 58 1e-08
Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 58 2e-08
CE21095 [R] KOG0725 Reductases with broad range of substrate spe... 58 2e-08
At3g26760 [R] KOG0725 Reductases with broad range of substrate s... 58 2e-08
Hs7657478 [Q] KOG1205 Predicted dehydrogenase 57 3e-08
7300387 [Q] KOG1208 Dehydrogenases with different specificities ... 57 3e-08
At3g29260 [R] KOG0725 Reductases with broad range of substrate s... 57 3e-08
CE05801 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 57 4e-08
At5g18210 [R] KOG0725 Reductases with broad range of substrate s... 57 4e-08
7297069 [Q] KOG1205 Predicted dehydrogenase 57 4e-08
At1g01800 [Q] KOG1208 Dehydrogenases with different specificitie... 56 6e-08
Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 56 7e-08
At3g03980 [R] KOG0725 Reductases with broad range of substrate s... 55 1e-07
7304176 [Q] KOG1208 Dehydrogenases with different specificities ... 55 1e-07
CE03132 [R] KOG0725 Reductases with broad range of substrate spe... 55 1e-07
At4g05530 [R] KOG0725 Reductases with broad range of substrate s... 55 1e-07
7292613 [Q] KOG1205 Predicted dehydrogenase 55 1e-07
YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 55 2e-07
SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase 55 2e-07
CE09969 [R] KOG0725 Reductases with broad range of substrate spe... 55 2e-07
7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 55 2e-07
7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 55 2e-07
CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 54 2e-07
7300831 [Q] KOG1205 Predicted dehydrogenase 54 2e-07
YIR035c [Q] KOG1204 Predicted dehydrogenase 54 3e-07
CE14538 [R] KOG0725 Reductases with broad range of substrate spe... 54 3e-07
CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 54 3e-07
7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 54 3e-07
SPCC162.03 [Q] KOG1205 Predicted dehydrogenase 54 4e-07
At5g15940 [Q] KOG1208 Dehydrogenases with different specificitie... 53 5e-07
CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 53 6e-07
CE03954 [R] KOG0725 Reductases with broad range of substrate spe... 53 6e-07
CE03613 [R] KOG1611 Predicted short chain-type dehydrogenase 53 6e-07
At2g24190 [Q] KOG1208 Dehydrogenases with different specificitie... 53 6e-07
Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 52 8e-07
Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase 52 8e-07
At3g51680 [R] KOG0725 Reductases with broad range of substrate s... 52 1e-06
7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 52 1e-06
SPAC8E11.10 [R] KOG0725 Reductases with broad range of substrate... 51 2e-06
Hs19923817 [R] KOG0725 Reductases with broad range of substrate ... 51 2e-06
Hs19923983 [R] KOG0725 Reductases with broad range of substrate ... 51 2e-06
CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase 50 3e-06
7304181 [Q] KOG1208 Dehydrogenases with different specificities ... 50 3e-06
7304180 [Q] KOG1208 Dehydrogenases with different specificities ... 50 3e-06
7304177 [Q] KOG1208 Dehydrogenases with different specificities ... 50 3e-06
CE19894 [R] KOG0725 Reductases with broad range of substrate spe... 50 4e-06
CE13008 [R] KOG0725 Reductases with broad range of substrate spe... 50 4e-06
At3g61220 [Q] KOG1208 Dehydrogenases with different specificitie... 50 4e-06
At2g47140 [R] KOG0725 Reductases with broad range of substrate s... 50 4e-06
7290386 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 50 4e-06
Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 50 5e-06
Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 50 5e-06
7304178 [Q] KOG1208 Dehydrogenases with different specificities ... 50 5e-06
7290936 [Q] KOG1204 Predicted dehydrogenase 50 5e-06
SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase 49 7e-06
CE21514 [R] KOG0725 Reductases with broad range of substrate spe... 49 7e-06
At1g52340 [R] KOG0725 Reductases with broad range of substrate s... 49 9e-06
>YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 297
Score = 323 bits (827), Expect = 2e-88
Identities = 164/273 (60%), Positives = 203/273 (74%), Gaps = 2/273 (0%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCI-PRKLDVSNQN 63
K A+VTGAS GIGYEVTKEL R G+ VYACARR PM +L +FG+ I P KLD+S
Sbjct: 10 KIAVVTGASGGIGYEVTKELARNGYLVYACARRLEPMAQLAIQFGNDSIKPYKLDISKPE 69
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+I L LPD KL LLYNNAGQSC+ PA+D ++ ++ F+VNV+G IN CRE +
Sbjct: 70 EIVTFSGFLRANLPDGKLDLLYNNAGQSCTFPALDATDAAVEQCFKVNVFGHINMCRELS 129
Query: 124 PLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGG 183
+I AKGTIVFTGSLAG+ FPFG++YSASKAAIHQYAR LH E+ P VRVIN ITGG
Sbjct: 130 EFLIKAKGTIVFTGSLAGVVSFPFGSIYSASKAAIHQYARGLHLEMKPFNVRVINAITGG 189
Query: 184 VATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARETVNDIENGSIDPV 243
VATDIADK+ LPE SI+NFPEG +A +RK M++ N+PM YA++ V DI + S DPV
Sbjct: 190 VATDIADKRPLPETSIYNFPEGREAFNSRKTMAKDNKPMPADAYAKQLVKDILSTS-DPV 248
Query: 244 DIYRGTMATVVKWLMLLIPYALLEWGLRKKFKL 276
D+YRGT A +++++M+ +PY LLE GL KKFKL
Sbjct: 249 DVYRGTFANIMRFVMIFVPYWLLEKGLSKKFKL 281
>SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 296
Score = 126 bits (317), Expect = 3e-29
Identities = 84/225 (37%), Positives = 123/225 (54%), Gaps = 10/225 (4%)
Query: 1 MSETKYALVTGASSG-IGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDV 59
M K+ L+TG S G IG + + + G+ V A AR+ M+ L + G + + KLDV
Sbjct: 1 MEAEKFVLITGCSEGGIGNALALKFHQEGFQVLATARQVERMDNL-TKAGLQTL--KLDV 57
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSC 119
++++ + +++ ++ ++ + LH L NNAG CS PAID+ E + VN YG I
Sbjct: 58 TDEDSVREVEQEV-RKFTNGSLHYLINNAGAPCSAPAIDLDIEDVSKVMDVNFYGVIRMN 116
Query: 120 REFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
+ F +I AKGTIV SL PF F A Y+ASKAA+ Y+ L EL P GV+V ++
Sbjct: 117 KAFQHQLIRAKGTIVNVNSLVSYVPFAFNAAYNASKAALLAYSNTLRIELAPFGVQVTSI 176
Query: 180 ITGGVATDIADKK--TLPEGSIFNFPEGIKAVETRKKMSEKNQPM 222
+TGGV T I K T+ E +I PE RK + E P+
Sbjct: 177 MTGGVQTKIQSKPLGTMTEAAI---PENSIYYPYRKLILENRNPV 218
>At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 299
Score = 104 bits (260), Expect = 1e-22
Identities = 77/259 (29%), Positives = 125/259 (47%), Gaps = 37/259 (14%)
Query: 3 ETKYALVTGASSG-IGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSN 61
E+ L+TG S G IG+ + +E +G V A +R M +L + R ++LDV +
Sbjct: 6 ESPVVLITGCSQGGIGHALAREFTEKGCRVVATSRSRSTMTDLEQD--SRLFVKELDVQS 63
Query: 62 QNDITQLKLKLEQELPDQ--KLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSC 119
+++ K+ E+ D+ K+ +L NNAG C P + ++NTF NV+G +
Sbjct: 64 DQNVS----KVLSEVIDKFGKIDVLVNNAGVQCVGPLAETPISAMENTFNTNVFGNKDLI 119
Query: 120 REF---------------------APLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAI 158
F ++ KG IV GS+ + P P+ VY+A+KAAI
Sbjct: 120 FSFNYYIYWSFNSSGSMRMTQAVVPHMVSKKKGKIVNVGSITVMAPGPWAGVYTATKAAI 179
Query: 159 HQYARVLHGELGPLGVRVINMITGGVATDIADK-----KTLPEGSIFNFPEGIKAVETRK 213
H L EL P G+ VIN++ GG+ T+IA+ +PE ++ E +A+ R
Sbjct: 180 HALTDTLRLELRPFGIDVINVVPGGIRTNIANSAVATFNKMPELKLYKPYE--EAIRERA 237
Query: 214 KMSEKNQPMSPADYARETV 232
+S++ P +AR+TV
Sbjct: 238 FISQRMNPTPAETFARDTV 256
>CE27259 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 501
Score = 82.8 bits (203), Expect = 6e-16
Identities = 60/193 (31%), Positives = 87/193 (44%), Gaps = 18/193 (9%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQNDIT 66
A+VTGASSGIG L R + + R + EL + S++ND+
Sbjct: 4 AIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAG-------SDKNDVL 56
Query: 67 QLKLKLEQELPDQ-----------KLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGP 115
++L E + ++ L N+AG + P +D E+ D VNV
Sbjct: 57 VTAVELASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYDELMNVNVRSL 116
Query: 116 INSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
I R P II KGT+V S+ G CPFP Y SK+A+ Q+ + L E+ P GVR
Sbjct: 117 IRLTRAALPHIITTKGTVVNVSSINGPCPFPNVTYYCMSKSAVDQFTKCLALEMAPNGVR 176
Query: 176 VINMITGGVATDI 188
V + G T++
Sbjct: 177 VNAVCPGVTVTNL 189
Score = 66.2 bits (160), Expect = 5e-11
Identities = 39/103 (37%), Positives = 53/103 (50%)
Query: 86 NNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFAPLIINAKGTIVFTGSLAGICPF 145
N+AG + P +D E+ D VNV I R P II KGT+V S+ G CPF
Sbjct: 382 NSAGILRAGPVLDSGIEVYDELMNVNVRSLIRLTRAALPHIITTKGTVVNVSSINGPCPF 441
Query: 146 PFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGGVATDI 188
Y SK+A+ Q+ + L E+ P GVRV + G + T+I
Sbjct: 442 AGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVCPGVIVTNI 484
>CE27260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 206
Score = 81.6 bits (200), Expect = 1e-15
Identities = 60/193 (31%), Positives = 87/193 (44%), Gaps = 18/193 (9%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQNDIT 66
A+VTGASSGIG L R + + R + EL + S++ND+
Sbjct: 4 AIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAG-------SDKNDVL 56
Query: 67 QLKLKLEQELPDQ-----------KLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGP 115
++L E + ++ L N+AG + P +D E+ D VNV
Sbjct: 57 VTAVELASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYDELMNVNVRSL 116
Query: 116 INSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
I R P II KGT+V S+ G CPF Y SK+A+ Q+ + L E+ P GVR
Sbjct: 117 IRLTRAALPHIITTKGTVVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVR 176
Query: 176 VINMITGGVATDI 188
V + G + T+I
Sbjct: 177 VNAVCPGVIVTNI 189
>CE21093 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 281
Score = 80.5 bits (197), Expect = 3e-15
Identities = 68/235 (28%), Positives = 106/235 (44%), Gaps = 16/235 (6%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K ALVTG+S+GIG + G V R +EE R E +P +S D
Sbjct: 8 KVALVTGSSNGIGRAAAVLFAKDGAKVTVTGRNAERLEETRQEILKSGVPESHVLSVATD 67
Query: 65 ITQLKLKLEQELPDQ------KLHLLYNNAGQSCS----LPAIDVSEEIIDNTFRVNVYG 114
+ K + EL + +L +L NNAG + + +D + D ++N+
Sbjct: 68 LAAEKG--QDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDKIMQINMRS 125
Query: 115 PINSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSA-SKAAIHQYARVLHGELGPLG 173
+ ++ ++ AKG IV S+AG G +Y A SK+A+ Q+ R +L G
Sbjct: 126 VVTLTQKAKEHLVKAKGEIVNVSSIAGTAHAQPGVMYYAMSKSALDQFTRCAAIDLIQYG 185
Query: 174 VRVINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYA 228
VRV ++ GGV T + +P G+ F E +K +E+RK+ P D A
Sbjct: 186 VRVNSVSPGGVTTGFGEAMGMPSGA---FEEMMKFMESRKECIPSGAVAKPIDIA 237
>At3g55310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 298
Score = 78.2 bits (191), Expect = 1e-14
Identities = 63/194 (32%), Positives = 100/194 (51%), Gaps = 11/194 (5%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF------GDRCIPRKLD 58
K LVTGASSGIG E+ +L + G V A ARR + L +E G + +LD
Sbjct: 39 KVVLVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQAAALELD 98
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLP-AIDVSEEIIDNTFRVNVYGPIN 117
VS+ Q ++ ++ K+ L NNAG ++ ++D+SE+ DN F N+ GP
Sbjct: 99 VSSDAATIQKAVREAWDI-FGKIDALINNAGIRGNVKLSLDLSEDEWDNVFNTNLKGPWL 157
Query: 118 SCREFAPLIINAK--GTIVFTGSLAGICPF-PFGAVYSASKAAIHQYARVLHGELGPLGV 174
+ L+ +AK G+++ S+AG+ P G YS SK + +R++ ELG +
Sbjct: 158 VAKYVCVLMRDAKRGGSVINISSVAGVRSIVPGGLAYSCSKGGVDTMSRMMAIELGVHKI 217
Query: 175 RVINMITGGVATDI 188
RV ++ G ++I
Sbjct: 218 RVNSIAPGLFKSEI 231
>7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 361
Score = 76.3 bits (186), Expect = 5e-14
Identities = 56/171 (32%), Positives = 88/171 (50%), Gaps = 9/171 (5%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGW---YVYACARRTHPMEELRAEFGDRCIPR--KLDV 59
K ALVTG SG+G E+ EL RRG V ++ + EL ++ RC+ + K DV
Sbjct: 93 KVALVTGGGSGLGREICLELARRGCKLAVVDVNSKGCYETVELLSKI-PRCVAKAYKNDV 151
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSC 119
S+ ++ + K+E+EL + +L NNA + + ID ++N+ I +
Sbjct: 152 SSPRELQLMAAKVEKEL--GPVDILVNNASLMPMTSTPSLKSDEIDTILQLNLGSYIMTT 209
Query: 120 REFAPLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGEL 169
+EF P +IN K G +V +LAG+ P P +Y+A+K I + L EL
Sbjct: 210 KEFLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAEL 260
>Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 387
Score = 75.9 bits (185), Expect = 7e-14
Identities = 57/194 (29%), Positives = 91/194 (46%), Gaps = 11/194 (5%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHP--MEELRAEFGDRCIPRKLDVS 60
+ K LVTG G+G+ + K L G+ V+A + EELR R ++D++
Sbjct: 81 DQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDIT 140
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNT-----FRVNVYGP 115
I K+ L D+ L + NNAG + E++ T VN +G
Sbjct: 141 KPVQIKDAYSKVAAMLQDRGLWAVINNAG----VLGFPTDGELLLMTDYKQCMAVNFFGT 196
Query: 116 INSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
+ + F PL+ +KG +V S+ G P A Y +SKAA+ ++ V+ EL G++
Sbjct: 197 VEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIK 256
Query: 176 VINMITGGVATDIA 189
V ++ GG T+IA
Sbjct: 257 VASIQPGGFLTNIA 270
>Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 343
Score = 74.7 bits (182), Expect = 2e-13
Identities = 65/233 (27%), Positives = 110/233 (46%), Gaps = 18/233 (7%)
Query: 4 TKYALVTGASSGIGYEVTKELLRRGWYVYA-CARRTHP---MEELRAEFGDRCIPRKLDV 59
+K LVTG SG G+ + K L +G+ V+A C + ++EL + DR +L+V
Sbjct: 55 SKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNV 114
Query: 60 SNQNDITQLKLKLEQEL--PDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPIN 117
+ ++ ++ + L P++ + L NNAG S S E VN++G +
Sbjct: 115 CSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVR 174
Query: 118 SCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
+ F PLI AKG +V S+ G P + Y +K + ++ L E+ PLGV+V
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
Query: 178 NMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARE 230
+ G + S+++ PE I+A+ KKM E+ + DY ++
Sbjct: 235 VVEPGNF---------IAATSLYS-PESIQAI--AKKMWEELPEVVRKDYGKK 275
>YMR226c [Q] KOG1205 Predicted dehydrogenase
Length = 267
Score = 74.3 bits (181), Expect = 2e-13
Identities = 69/197 (35%), Positives = 96/197 (48%), Gaps = 16/197 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRG---WYVYACARRTHPMEELRAEFGDRCIPRKLDVSN 61
K L+TGAS+GIG E L + ARR +EEL+ K+ V+
Sbjct: 14 KTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHVA- 72
Query: 62 QNDITQL-KLK-----LEQELPDQKLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYG 114
Q DITQ K+K L QE D + +L NNAG++ + ++ E I + F NV
Sbjct: 73 QLDITQAEKIKPFIENLPQEFKD--IDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTA 130
Query: 115 PINSCREFAPLIINAK--GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPL 172
IN + P I AK G IV GS+AG +P G++Y ASK A+ + L EL
Sbjct: 131 LINITQAVLP-IFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELINT 189
Query: 173 GVRVINMITGGVATDIA 189
+RVI + G V T+ +
Sbjct: 190 KIRVILIAPGLVETEFS 206
>CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 388
Score = 74.3 bits (181), Expect = 2e-13
Identities = 77/284 (27%), Positives = 122/284 (42%), Gaps = 30/284 (10%)
Query: 2 SETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPR------ 55
S KY ++TG SG G + LL + V+A M L +E+ + P+
Sbjct: 30 SSGKYVMITGCDSGFGRLLATSLLDKHVNVFAACFTQQGMASLHSEWKLKKGPKGQLYTL 89
Query: 56 KLDVSNQNDITQLKLKLEQELPDQ--KLHLLYNNAG-QSCSLPAIDVSEEIIDNTFRVNV 112
+LDV++Q + K + + L +Q KL L NNAG S P S + ++ VN
Sbjct: 90 QLDVTSQASVDSAKSFVTKILKEQNSKLWGLVNNAGIFSIHGPDDWCSVDEYASSLNVNT 149
Query: 113 YGPINSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPL 172
G + C F PLI ++G IV GS AG + A Y +K A+ Y L E+ P
Sbjct: 150 LGAVRMCHAFVPLIKKSRGRIVTMGSTAGRLHGLYVAPYVTAKFAVEAYMDCLRLEMRPF 209
Query: 173 GVRVINMITGGVATDIA--DKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARE 230
GV V + G T++ D + + I+N +VET++ +Y +
Sbjct: 210 GVSVHILEPGCFKTELLNNDAQRMRIQKIWN----SLSVETKE------------EYGED 253
Query: 231 TVNDIENGSIDPVDIYRGTMATVVKWLMLLIPYALLEWGLRKKF 274
ND E V++ + W++ +AL W R ++
Sbjct: 254 YRNDFERAWEAGVNVVANPN---IGWVVDCYSHALFSWWPRLRY 294
>7296705 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 74.3 bits (181), Expect = 2e-13
Identities = 68/251 (27%), Positives = 107/251 (42%), Gaps = 8/251 (3%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPM----EELRAEFGDRCIPRKLDVS 60
K +VTGASSGIG + L + G + R + E++ A G + D++
Sbjct: 7 KVIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVAADIN 66
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAID-VSEEIIDNTFRVNVYGPINSC 119
+++D+ + + ++ +L NNAG L +I+ S E D NV
Sbjct: 67 SESDVQGIVSATLAK--HGRIDVLVNNAG-ILELGSIENTSLEQFDRVMNTNVRSLYQLT 123
Query: 120 REFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
P +I KG IV S+ GI FP Y+ SKAA+ Q+ R + EL P GVRV ++
Sbjct: 124 HLVTPELIKTKGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVNSV 183
Query: 180 ITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARETVNDIENGS 239
G + T++ + L + + F E K + E + + + G
Sbjct: 184 NPGVIITELQRRGGLDQEAYVKFLEHAKVTHALGRPGEVKEVAAAIAFLASDEASFSTGI 243
Query: 240 IDPVDIYRGTM 250
PVD R M
Sbjct: 244 SLPVDGGRHAM 254
>At1g07440 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 266
Score = 73.6 bits (179), Expect = 3e-13
Identities = 54/197 (27%), Positives = 91/197 (45%), Gaps = 15/197 (7%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ 62
+ K LVTG + GIG+ + +E G ++ CAR + + E +++ +K
Sbjct: 13 KAKTVLVTGGTKGIGHAIVEEFAGFGAVIHTCARNEYELNECLSKW------QKKGFQVT 66
Query: 63 NDITQLKLKLEQELPDQ--------KLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYG 114
+ L+ E+E Q KL +L NN G S P +D + E N+
Sbjct: 67 GSVCDASLRPEREKLMQTVSSMFGGKLDILINNLGAIRSKPTLDYTAEDFSFHISTNLES 126
Query: 115 PINSCREFAPLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
+ + PL+ + G I+F S+AG+ G++YSA+K A++Q AR L E G
Sbjct: 127 AYHLSQLAHPLLKASGCGNIIFMSSIAGVVSASVGSIYSATKGALNQLARNLACEWASDG 186
Query: 174 VRVINMITGGVATDIAD 190
+R + +AT +A+
Sbjct: 187 IRANAVAPAVIATPLAE 203
>7290108 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 73.2 bits (178), Expect = 4e-13
Identities = 58/185 (31%), Positives = 84/185 (45%), Gaps = 8/185 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF-GDRCIPRKLDVSNQN 63
K +VTGASSGIG + + L R G + R +E + G + DV+
Sbjct: 6 KVVIVTGASSGIGAAIAQVLAREGATLALVGRNVANLEATKKSLKGTQAEIVVADVTKDA 65
Query: 64 DITQLKLKLEQELPD-QKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREF 122
D ++Q L ++ +L NNAG ID+ E D N+ G I +
Sbjct: 66 DAI-----VQQTLAKFGRIDVLVNNAGILGKGGLIDLDIEEFDAVLNTNLRGVILLTKAV 120
Query: 123 APLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
P ++ KG +V S AGI PF Y SKAA+ Q+ +++ E+ P GVRV N +
Sbjct: 121 LPHLLKTKGAVVNVSSCAGIRPFAGALSYGVSKAALDQFTKIVALEMAPQGVRV-NSVNP 179
Query: 183 GVATD 187
G D
Sbjct: 180 GFRGD 184
>At3g03330 [Q] KOG1205 Predicted dehydrogenase
Length = 345
Score = 72.8 bits (177), Expect = 6e-13
Identities = 55/190 (28%), Positives = 87/190 (44%), Gaps = 8/190 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDV----- 59
K +TGAS GIG + K+ + AR ++ +++E + P + V
Sbjct: 44 KVVWITGASRGIGEILAKQFASLDAKLILSARNKAELDRVKSELKGKFAPEDVKVLPLDL 103
Query: 60 -SNQNDITQLKLKLEQELPDQKL-HLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPIN 117
S + + + + P + +L++N A + A D SEE + TF VNV+G I+
Sbjct: 104 ASGEESLKHVVEQAVSLFPGAGVDYLVHNAAFERPKSKASDASEETLKTTFDVNVFGTIS 163
Query: 118 SCREFAP-LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRV 176
+ AP ++ G V S AG P P A+YSASK A+H Y L E G++V
Sbjct: 164 LTKLVAPHMLKQGGGHFVVISSAAGKVPSPGQAIYSASKHALHGYFHSLRSEFCQKGIKV 223
Query: 177 INMITGGVAT 186
+ G + T
Sbjct: 224 TVVCPGPIET 233
>At1g63380 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 287
Score = 72.8 bits (177), Expect = 6e-13
Identities = 66/229 (28%), Positives = 111/229 (47%), Gaps = 26/229 (11%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAE------FGDRCIPRKLD 58
K LVTGASSGIG E+ +L + G + A ARR + L +E G + + +LD
Sbjct: 25 KVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAVALELD 84
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSL-PAIDVSEEIIDNTFRVNVYGPIN 117
VS++ D + +K E K+ +L NNAG ++ ++D+SEE D FR N+ G
Sbjct: 85 VSSEADTIRKAVKEAWE-TFGKIDVLINNAGIRGNVKSSLDLSEEEWDKVFRTNLTGSWL 143
Query: 118 SCREFAPLIINAK--GTIVFTGSLAGICP--FPFGAVYSASKAAIHQYARVLHGELGPLG 173
+ L+ +A+ G+++ S++G+ G Y+ SK + R++ EL
Sbjct: 144 ISKYVCLLMRDAERGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELAVYK 203
Query: 174 VRVINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPM 222
+RV ++ G ++I +G+ E KK++EK P+
Sbjct: 204 IRVNSIAPGIFRSEIT--------------QGLFQKEWLKKVTEKVVPL 238
>Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 72.0 bits (175), Expect = 1e-12
Identities = 51/175 (29%), Positives = 80/175 (45%), Gaps = 2/175 (1%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ 62
+ KY +TG SG G + ++L RG V A E+LR + DR LDV+
Sbjct: 28 QDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKM 87
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAID-VSEEIIDNTFRVNVYGPINSCRE 121
I +++ + D+ L L NNAG + + ++ E N +VN+ G I
Sbjct: 88 ESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLS 147
Query: 122 FAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRV 176
PL+ A+G IV S+ G F G Y SK + ++ +L E+ GV++
Sbjct: 148 MLPLVRRARGRIVNVSSILGRVAFFVGG-YCVSKYGVEAFSDILRREIQHFGVKI 201
>At2g29350 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 72.0 bits (175), Expect = 1e-12
Identities = 55/188 (29%), Positives = 90/188 (47%), Gaps = 5/188 (2%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTG S GIG V +EL G V+ CAR ++E E+ G + DVS+++
Sbjct: 20 ALVTGGSKGIGEAVVEELAMLGAKVHTCARDETQLQERLREWQAKGFQVTTSVCDVSSRD 79
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+L ++ L KL++L NN G S P + + E N+ + +
Sbjct: 80 QRVKL-METVSSLYQGKLNILVNNVGTSIFKPTTEYTAEDFSFVMATNLESAFHLSQLAH 138
Query: 124 PLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
PL+ + G+IV S AG+ G++Y A+K A++Q AR L E +R ++
Sbjct: 139 PLLKASGSGSIVLISSAAGVVHVNVGSIYGATKGAMNQLARNLACEWASDNIRTNSVCPW 198
Query: 183 GVATDIAD 190
+ T +++
Sbjct: 199 YITTPLSN 206
>CE07539 [Q] KOG1205 Predicted dehydrogenase
Length = 537
Score = 71.2 bits (173), Expect = 2e-12
Identities = 65/241 (26%), Positives = 105/241 (42%), Gaps = 22/241 (9%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ 62
+ K ++TGASSG+G + EL +RG V AR T ++E+ AE K N+
Sbjct: 77 KNKIVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICAEL------TKTFPLNK 130
Query: 63 N-------DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGP 115
N DIT ++P K+ +L NNAG S D + I N++G
Sbjct: 131 NKPTYYFFDITNPDKAPWAQIP--KVDVLINNAGMSNRGSCQDTTMAIHRKAMETNLFGH 188
Query: 116 INSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
+ + ++ G IV T S+ G P+ YSASK A+ Y L E L +
Sbjct: 189 VQVTQSLLSK-LSPDGCIVVTSSIQGKVAIPYRGSYSASKHALQGYFDCLRAEHKNLHIL 247
Query: 176 VINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARETVNDI 235
V++ G + T + +G + G++ +K S ++ +D R+ V+D
Sbjct: 248 VVS--AGYINTGFGSRALDTDGKVV----GVEDENQKKGYSPEHSARMISDAIRDRVSDF 301
Query: 236 E 236
+
Sbjct: 302 D 302
>7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 308
Score = 71.2 bits (173), Expect = 2e-12
Identities = 57/188 (30%), Positives = 84/188 (44%), Gaps = 6/188 (3%)
Query: 6 YALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRC---IPRKLDVSNQ 62
+A VTGAS GIG E KEL R+ V AR ++ + E D C + K+ +++
Sbjct: 51 WAAVTGASDGIGKEYAKELARQNINVVLIARTEEKLQAVAKEIAD-CGAGVQTKIVIADF 109
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREF 122
+Q+ +E+E + + +L NN G + + ++E N NV R F
Sbjct: 110 TKGSQVYEHIEKETANIPISILVNNVGIATPKSLLKYNQEETQNIIDTNVVAVSQLSRIF 169
Query: 123 APLI--INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMI 180
+ KG IV GS + P P GA Y+ASKA L+ E P G+ V +
Sbjct: 170 FQRMKASKLKGAIVNVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQMLS 229
Query: 181 TGGVATDI 188
V T I
Sbjct: 230 PNFVVTKI 237
>YBR159w [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 347
Score = 70.9 bits (172), Expect = 2e-12
Identities = 49/179 (27%), Positives = 84/179 (46%), Gaps = 14/179 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDR--CIPRKLDVSNQ 62
KY +TGAS GIG E +++ +RG+ + +R +E L+ E D+ + + L +
Sbjct: 63 KYCAITGASDGIGKEFARQMAKRGFNLVLISRTQSKLEALQKELEDQHHVVVKILAIDIA 122
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPA--IDVSEEIIDNTFRVNVYGPINSCR 120
D +++ + +L NN GQS S+P ++ E+ + N +N + +
Sbjct: 123 EDKESNYESIKELCAQLPITVLVNNVGQSHSIPVPFLETEEKELRNIITINNTATLLITQ 182
Query: 121 EFAPLII----------NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGEL 169
AP I+ +G I+ GS G+ P P A YS SK+ + ++ L GEL
Sbjct: 183 IIAPKIVETVKAENKKSGTRGLILTMGSFGGLIPTPLLATYSGSKSFLQGWSNSLAGEL 241
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 70.5 bits (171), Expect = 3e-12
Identities = 68/231 (29%), Positives = 106/231 (45%), Gaps = 21/231 (9%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWY-VYACARRTHPMEELRAEFGDR----CIPRKLDV 59
K L+TGASSGIG E+ + + ARR +EE+ E + +P KLDV
Sbjct: 7 KTILITGASSGIGKSTAFEIAKVAKVKLILAARRFSTVEEIAKELESKYEVSVLPLKLDV 66
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLP-AIDVSEEIIDNTFRVNVYGPINS 118
S+ I + L +E D + +L NNAG + ID++ + NV G +
Sbjct: 67 SDLKSIPGVIESLPKEFAD--IDVLINNAGLALGTDKVIDLNIDDAVTMITTNVLGMMAM 124
Query: 119 CREFAPLIINA-KGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
R P+ + KG I+ GS+AG + G+VY ++K+A+ Q+ L E +R++
Sbjct: 125 TRAVLPIFYSKNKGDILNVGSIAGRESYVGGSVYCSTKSALAQFTSALRKETIDTRIRIM 184
Query: 178 NMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYA 228
+ G V T E S+ F + + K SE P++P D A
Sbjct: 185 EVDPGLVET---------EFSVVRFHGDKQKADNVYKNSE---PLTPEDIA 223
>At3g46170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 288
Score = 70.5 bits (171), Expect = 3e-12
Identities = 66/228 (28%), Positives = 112/228 (48%), Gaps = 25/228 (10%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF------GDRCIPRKLD 58
K LVTGASSGIG E+ +L + G + A ARR + L +E G + KLD
Sbjct: 29 KVVLVTGASSGIGREICLDLGKAGCKIIAVARRVDRLNSLCSEINSSSSTGIQAAALKLD 88
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSL-PAIDVSEEIIDNTFRVNVYGPIN 117
V++ Q ++ + K+ L NNAG ++ ++D+S+E DN F+ N+ GP
Sbjct: 89 VTSDAATIQKVVQGAWGI-FGKIDALINNAGIRGNVKSSLDLSKEEWDNVFKTNLTGPWL 147
Query: 118 SCREFAPLIINAK--GTIVFTGSLAGICPFPFGAV-YSASKAAIHQYARVLHGELGPLGV 174
+ L+ +AK G+++ S+AGI GA+ Y+ SK + ++++ ELG +
Sbjct: 148 VSKYVCVLMRDAKLGGSVINISSIAGIRGILPGALAYACSKIGVDTMSKMMAVELGVHKI 207
Query: 175 RVINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPM 222
RV ++ G ++I +G+ E K ++E+ P+
Sbjct: 208 RVNSIAPGIFKSEIT--------------QGLMQKEWFKNVTERTVPL 241
>At2g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 322
Score = 70.5 bits (171), Expect = 3e-12
Identities = 50/174 (28%), Positives = 85/174 (48%), Gaps = 5/174 (2%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTG + GIG + +EL G V+ CAR + +E +++ G R DVS+++
Sbjct: 73 ALVTGGTRGIGRAIVEELAGLGAEVHTCARNEYELENCLSDWNRSGFRVAGSVCDVSDRS 132
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
L ++ + + KLH+L NN G + P ++ + N + C+
Sbjct: 133 QREAL-METVSSVFEGKLHILVNNVGTNIRKPMVEFTAGEFSTLMSTNFESVFHLCQLAY 191
Query: 124 PLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRV 176
PL+ +K G++VF S++G +V S++K AI+Q R L E +R+
Sbjct: 192 PLLRESKAGSVVFISSVSGFVSLKNMSVQSSTKGAINQLTRSLACEWAKDNIRI 245
>At5g04900 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 341
Score = 70.1 bits (170), Expect = 4e-12
Identities = 56/193 (29%), Positives = 93/193 (48%), Gaps = 14/193 (7%)
Query: 8 LVTGASSGIGYEVTKELLRRGWYVYACARRTHPME----ELRAEFGDRCIPRKLDVSNQN 63
L+TG++ GIGY + +E L+ G V C+R +E L+ EFG+ K DV+
Sbjct: 83 LITGSTKGIGYALAREFLKAGDNVVICSRSAERVETAVQSLKEEFGEHVWGTKCDVTEGK 142
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSC--SLPAIDVSEEIIDNTFRVNVYGPINSCRE 121
D+ +L ++ L + + + NNAG + P + S+E + + N G + CRE
Sbjct: 143 DVRELVAYSQKNL--KYIDIWINNAGSNAYSFKPLAEASDEDLIEVVKTNTLGLMLCCRE 200
Query: 122 FAPLII-NAKGTIVFTGSLAGI--CPFPFGAVYSASKAAIHQYARVLHGELGPLGVR--- 175
+++ ++G +F AG P P A Y A+K ++ + L EL V+
Sbjct: 201 AMNMMLTQSRGGHIFNIDGAGSDGRPTPRFAAYGATKRSVVHLTKSLQAELQMQDVKNVV 260
Query: 176 VINMITGGVATDI 188
V N+ G V TD+
Sbjct: 261 VHNLSPGMVTTDL 273
>HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 69.7 bits (169), Expect = 5e-12
Identities = 54/189 (28%), Positives = 85/189 (44%), Gaps = 2/189 (1%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
KY +TG SG G + ++L RG V A E+LR + DR LDV+
Sbjct: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTES 89
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSC-SLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+ +++ + D+ L L NNAG S + P ++++ VN+ G I+
Sbjct: 90 VAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLL 149
Query: 124 PLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGG 183
PL+ A+G +V S+ G FG Y SK + ++ L EL GV+V + G
Sbjct: 150 PLVRKARGRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGY 208
Query: 184 VATDIADKK 192
T + K+
Sbjct: 209 FKTAVTSKE 217
>7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 242
Score = 69.7 bits (169), Expect = 5e-12
Identities = 55/172 (31%), Positives = 82/172 (46%), Gaps = 7/172 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K LVTGA +GIG + K+L G V A AR+ +++L A P +LD+S
Sbjct: 8 KVILVTGAGAGIGQALVKQLASAGATVIAVARKPEQLQQLVAFDPVHIQPLQLDLSGWQA 67
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFAP 124
+ + K+ L L NNAG + P +++E+ D F VN+ N + P
Sbjct: 68 VREGLAKV------PLLDGLVNNAGVAIIKPFEELTEQDFDTHFDVNIKAVFNVTQSLLP 121
Query: 125 LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRV 176
+ + +IV S+A F YSA+KAA+ + L ELGP +RV
Sbjct: 122 RLKDG-ASIVNVSSIASSRSFGGHTAYSATKAALDSLTKSLALELGPRKIRV 172
>7296047 [Q] KOG1205 Predicted dehydrogenase
Length = 321
Score = 69.3 bits (168), Expect = 6e-12
Identities = 55/194 (28%), Positives = 88/194 (45%), Gaps = 22/194 (11%)
Query: 9 VTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQNDITQL 68
+TGASSGIG + L R G + ARR +E+++ E C+ + D+ +
Sbjct: 51 ITGASSGIGRALALSLARHGVKLVLSARRLEQLEQVQEE----CLAAARGLLATKDVLVI 106
Query: 69 KLKLEQELPDQKLHL------------LYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPI 116
++ + +L + K HL L NNAG+S +V E+ F ++V+ +
Sbjct: 107 QMDM-LDLDEHKTHLNTVLNHFHRLDVLVNNAGRSQRASWTEVEIEVDRELFELDVFAVV 165
Query: 117 NSCREFAPLIIN---AKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
+ R + +G I T S+AG P PF Y A+K A++ Y L E+ L
Sbjct: 166 HLSRLVVRYFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVEMRKLD 225
Query: 174 VRVINMITGGVATD 187
V + G +ATD
Sbjct: 226 VSL--FAPGPIATD 237
>Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 68.9 bits (167), Expect = 8e-12
Identities = 54/189 (28%), Positives = 86/189 (44%), Gaps = 2/189 (1%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
KY +TG SG G + ++L RG V A E+LR + DR LDV+
Sbjct: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTES 89
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSC-SLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+ +++ + D+ L L NNAG S + P ++++ + VN+ G I+
Sbjct: 90 VAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDLLTILDVNLLGVIDVTLNLL 149
Query: 124 PLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGG 183
PL+ A+G +V S+ G FG Y SK + ++ L EL GV+V + G
Sbjct: 150 PLVRRARGRVVNVFSVMGRVSL-FGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGY 208
Query: 184 VATDIADKK 192
T + K+
Sbjct: 209 FKTAVTSKE 217
>At5g06060 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 68.9 bits (167), Expect = 8e-12
Identities = 63/224 (28%), Positives = 100/224 (44%), Gaps = 18/224 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ-- 62
K ALVTG + GIG V +EL + G V+ C+R EEL A D L VS
Sbjct: 12 KTALVTGGTRGIGRAVVEELAKFGAKVHTCSRN---QEELNACLND-WKANGLVVSGSVC 67
Query: 63 -NDITQLKLKLEQELPDQ---KLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINS 118
+ + KL QE KL++L NN G + P ++ S E N+ +
Sbjct: 68 DASVRDQREKLIQEASSAFSGKLNILINNVGTNVRKPTVEYSSEEYAKIMSTNLESAFHL 127
Query: 119 CREFAPLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
+ PL+ + G+IVF S+AG+ G++Y A+K A++Q R L E +R
Sbjct: 128 SQIAHPLLKASGVGSIVFISSVAGLVHLSSGSIYGATKGALNQLTRNLACEWASDNIRTN 187
Query: 178 NMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQP 221
+ + T + + ++ E ++AV +R + +P
Sbjct: 188 CVAPWYIKTSLVE-------TLLEKKEFVEAVVSRTPLGRVGEP 224
>At2g29170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 68.9 bits (167), Expect = 8e-12
Identities = 53/186 (28%), Positives = 90/186 (47%), Gaps = 5/186 (2%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTG S G+G V +EL G V+ CAR ++E E+ G DVS+++
Sbjct: 21 ALVTGGSKGLGEAVVEELAMLGARVHTCARNETQLQECVREWQAKGFEVTTSVCDVSSRD 80
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+L ++ + KL++L NNAG + P + + + N+ + +
Sbjct: 81 QREKL-MENVASIFQGKLNILVNNAGTGITKPTTEYTAQDYSFLMATNLDSAFHLSQLAH 139
Query: 124 PLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
PL+ + G+IV S AG+ G++Y A+K A++Q A+ L E +RV ++
Sbjct: 140 PLLKASGSGSIVLMSSTAGVVHINVGSIYGATKGAMNQLAKNLACEWARDNIRVNSVCPW 199
Query: 183 GVATDI 188
+AT +
Sbjct: 200 FIATPL 205
>CE07544 [Q] KOG1205 Predicted dehydrogenase
Length = 262
Score = 68.6 bits (166), Expect = 1e-11
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 6/198 (3%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRC-IPRKLDVSN 61
+ K ++TGASSG+G + EL +RG V AR T ++E+ E + + + +
Sbjct: 46 KNKVVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICEELKETFPLNQNEPIYY 105
Query: 62 QNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCRE 121
DIT + E+P ++ +L NNAG S D + EI N +G ++ +
Sbjct: 106 YFDITDSEQAPWAEIP--RVDILINNAGMSNRGSCQDTTMEIHRQAMETNYFGHVHVTQA 163
Query: 122 FAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMIT 181
++ G IV T S+ G P+ Y ASK A+ Y L E L + V++
Sbjct: 164 LLSK-LSPDGCIVVTSSIQGKVAIPYRGSYGASKHALQGYFDCLRAEHKNLHILVVS--A 220
Query: 182 GGVATDIADKKTLPEGSI 199
G + T + P G +
Sbjct: 221 GYINTGFGSRALDPSGKV 238
>CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 251
Score = 68.6 bits (166), Expect = 1e-11
Identities = 60/180 (33%), Positives = 84/180 (46%), Gaps = 10/180 (5%)
Query: 14 SGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGD---RCIPRKLDVSNQNDITQLKL 70
+GIG E+ L + G V A AR + L E IP DVS ++
Sbjct: 19 AGIGKEICLSLAKAGAQVIAFARNEANLLSLVKETTSLRYTIIPIVGDVSANEEVL---- 74
Query: 71 KLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFAPLIINA- 129
+ +P +H L NNAG + + ++++ ID TF VNV GPI + A ++
Sbjct: 75 -FKLIVPHFPIHGLVNNAGIATNHAIGQITQQSIDRTFAVNVRGPILIAQLVARNFVDRQ 133
Query: 130 -KGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGGVATDI 188
KG+IV S A I P VY ASKAA+ R L ELG +RV ++ V TD+
Sbjct: 134 IKGSIVNISSQAAIRPLDNHTVYCASKAALDMVTRCLANELGSQNIRVNSVNPTVVMTDM 193
>CE15574 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 67.8 bits (164), Expect = 2e-11
Identities = 66/233 (28%), Positives = 103/233 (43%), Gaps = 12/233 (5%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K ALVTG+S+GIG L R G V R +EE + E +P +S D
Sbjct: 7 KVALVTGSSNGIGRATAILLAREGAKVTITGRNAQRLEETKQEILRSGVPEDHVLSIIAD 66
Query: 65 IT----QLKLKLEQELPDQKLHLLYNNAGQSCS----LPAIDVSEEIIDNTFRVNVYGPI 116
+ Q++L +L +L NNAG + + + + + D T R+N+ +
Sbjct: 67 LATESGQIELMNSTVDIFGRLDILVNNAGAAITDLEGHIGVGTNVSVFDKTMRINLRSVV 126
Query: 117 NSCREFAPLIINAKGTIVFTGSLA-GICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
++ +I KG IV S+A G P Y+ SK+A+ QY R +L GVR
Sbjct: 127 TLTQKAKEHLIKTKGEIVNVSSIAGGQHAQPELIYYAMSKSALDQYTRSAAIDLIQHGVR 186
Query: 176 VINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYA 228
V ++ G + T I + + + S+ N K +E+RK+ P D A
Sbjct: 187 VNSVSPGDIRTGIYETMGMNKESVENI---YKFMESRKECCPIGTIAQPVDVA 236
>At1g62610 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 307
Score = 67.8 bits (164), Expect = 2e-11
Identities = 64/229 (27%), Positives = 109/229 (46%), Gaps = 26/229 (11%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAE------FGDRCIPRKLD 58
K LVTGASSGIG E+ +L + G + A ARR + L +E G + +LD
Sbjct: 47 KVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAAALELD 106
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSL-PAIDVSEEIIDNTFRVNVYGPIN 117
VS+ D + +K E+ + +L NNAG ++ ++D+S+E D FR N+ G
Sbjct: 107 VSSDADTIRKAVKEAWEI-FGTIDVLINNAGIRGNVKSSLDLSKEEWDKVFRTNLTGSWL 165
Query: 118 SCREFAPLIINAK--GTIVFTGSLAGICP--FPFGAVYSASKAAIHQYARVLHGELGPLG 173
+ L+ +AK G+++ S++G+ G Y+ SK + R++ EL
Sbjct: 166 ISKYVCLLMRDAKRGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELAVYK 225
Query: 174 VRVINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPM 222
+RV ++ G ++I +G+ E +K++EK P+
Sbjct: 226 IRVNSIAPGIFRSEIT--------------QGLFQKEWLEKVTEKIVPL 260
>Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 312
Score = 67.4 bits (163), Expect = 2e-11
Identities = 56/222 (25%), Positives = 104/222 (46%), Gaps = 9/222 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
++A+VTG++ GIG +EL + G V +R ++++ +E ++ ++
Sbjct: 51 EWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFA 110
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFAP 124
+ K++ L ++ +L NN G S P + +DN + + I S +
Sbjct: 111 SEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQ 170
Query: 125 LII-----NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
L++ +KG I+ S +G+ P P +YSA+K + +++ LH E GV V ++
Sbjct: 171 LVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSV 230
Query: 180 ITGGVATDIAD--KKTLPEGSIFNFPEGIKAVETRKKMSEKN 219
+ VAT +A K TL + S F + A++T S N
Sbjct: 231 LPYFVATKLAKIRKPTLDKPSPETFVK--SAIKTVGLQSRTN 270
>Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 405
Score = 67.4 bits (163), Expect = 2e-11
Identities = 56/181 (30%), Positives = 83/181 (44%), Gaps = 13/181 (7%)
Query: 4 TKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPR----KLDV 59
T+ L+TG SG G E K+L G+ V A + + E C PR ++D+
Sbjct: 82 TRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAI--ELRTCCSPRLRLLQMDL 139
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFR----VNVYGP 115
+ DI++L + L L NNAG + + ++S TFR VN +G
Sbjct: 140 TKPGDISRLLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVA---TFRSCMEVNFFGA 196
Query: 116 INSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
+ + PL+ +++G IV GS AG P+P Y SKAA+ EL P GV+
Sbjct: 197 LELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVK 256
Query: 176 V 176
V
Sbjct: 257 V 257
>At2g29340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 67.4 bits (163), Expect = 2e-11
Identities = 56/200 (28%), Positives = 97/200 (48%), Gaps = 13/200 (6%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTG +SGIGY + +EL G ++ C + + +E+ G + DV+++
Sbjct: 12 ALVTGGASGIGYAIVEELAGFGARIHVCDISEAKLNQSLSEWEKKGFQVSGSVCDVASRP 71
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+ +L + + D KL++L +N G S P + +E+ NV + +
Sbjct: 72 EREELMQTVSSQF-DGKLNILVSNVGVIRSKPTTEYTEDDFAFHISSNVEAAYHFSQLSH 130
Query: 124 PLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR------- 175
PL+ + G+I+F S+AG+ F G++Y +K A+ Q A+ L E G+R
Sbjct: 131 PLLKASGYGSIIFVSSIAGVISFDAGSIYGLTKGALIQLAKNLACEWAKDGIRANAVAPN 190
Query: 176 VINM-ITGGVATDIADKKTL 194
VIN ++ D++ KK L
Sbjct: 191 VINTPLSQSYLEDVSFKKAL 210
>At2g29290 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/228 (28%), Positives = 98/228 (42%), Gaps = 19/228 (8%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACAR-RTHPMEELR--AEFGDRCIPRKLDVSNQN 63
ALVTG + GIG V +EL G V+ CAR T E LR E G + DVS +
Sbjct: 12 ALVTGGTKGIGEAVVEELSILGARVHTCARDETQLQERLREWQEKGFQVTTSICDVSLRE 71
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+L ++ L KL++L NN G P + + E N+ + +
Sbjct: 72 QREKL-METVSSLFQGKLNILVNNVGTLMLKPTTEYTAEEFSFLMATNLDSAFHISQLAH 130
Query: 124 PLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
PL+ + G+IV S+AG+ G++Y A+K A++Q AR L E +R +
Sbjct: 131 PLLKASGSGSIVLMSSIAGVVHVGVGSIYGATKGAMNQLARNLACEWASDNIRTNAICPW 190
Query: 183 GVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARE 230
+ T + + +VE KK +E+ PM A E
Sbjct: 191 LITTPLI--------------SDLLSVEEMKKEAEERTPMGRVGEANE 224
>7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 321
Score = 67.0 bits (162), Expect = 3e-11
Identities = 51/193 (26%), Positives = 92/193 (47%), Gaps = 9/193 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDR--CIPRKLDVSNQ 62
++A+VTG++ GIG KEL RRG + +R + + E GD+ R +DV
Sbjct: 53 EWAVVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFT 112
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLP-----AIDVSEEIIDNTFRVNVYGPIN 117
++ K+ ++ + +L NN G S P + N N++ +
Sbjct: 113 GG-DEIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTH 171
Query: 118 SCREFAP-LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRV 176
F P +I +G I+ S AG+ P P +VYS++KA +++++ L E G+ +
Sbjct: 172 MTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILI 231
Query: 177 INMITGGVATDIA 189
++ G VAT+++
Sbjct: 232 QSVQPGFVATNMS 244
>SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 341
Score = 66.2 bits (160), Expect = 5e-11
Identities = 48/183 (26%), Positives = 88/183 (47%), Gaps = 12/183 (6%)
Query: 6 YALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGD--RCIPRKLDVSNQN 63
+A+VTGA+ GIG E +L G+ V +R ++ L E + R + +
Sbjct: 59 WAVVTGATDGIGKEYATQLAMSGFNVVLISRTQEKLDALAKELETVAKVKTRTIAIDYTK 118
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPA--IDVSEEIIDNTFRVNVYGPINSCRE 121
+ KL Q+L + +L NN GQS +P + + + +D+ +N +G +++ +
Sbjct: 119 TTAETFEKLHQDLVGTPITVLINNVGQSHYMPTSFAETTVKEMDDIMHINCFGTLHTTKA 178
Query: 122 FAPLII-----NAKGT---IVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
+++ N KG I+ GS AG+ P P+ + Y+ SKA + ++ L E+ G
Sbjct: 179 VLSIMLRERQKNEKGPRCLILTMGSFAGLLPSPYLSTYAGSKAFLSNWSASLGEEVKKQG 238
Query: 174 VRV 176
+ V
Sbjct: 239 IDV 241
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 66.2 bits (160), Expect = 5e-11
Identities = 58/202 (28%), Positives = 90/202 (43%), Gaps = 13/202 (6%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K ALVTG+S+GIG L + G V R +EE R E +P +S D
Sbjct: 7 KVALVTGSSNGIGRATAVLLAQEGAKVTITGRNADRLEETRQEILKSGVPEDHVLSIATD 66
Query: 65 ITQLKLKLEQELPDQ------KLHLLYNNAGQSCS----LPAIDVSEEIIDNTFRVNVYG 114
+ K + EL + +L +L NNAG + + +D + D ++N+
Sbjct: 67 LA--TEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDRIMQINMRS 124
Query: 115 PINSCREFAPLIINAKGTIVFTGSL-AGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
+ ++ ++ AKG +V S+ AG P Y+ SKAA+ QY R +L G
Sbjct: 125 VVTLTQKAKEHLVKAKGEVVNVSSIGAGPQAQPTFMYYAMSKAALDQYTRSAAIDLIQYG 184
Query: 174 VRVINMITGGVATDIADKKTLP 195
VRV ++ G V T + +P
Sbjct: 185 VRVNSVSPGAVVTGFGEAMGMP 206
>At2g29150 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 66.2 bits (160), Expect = 5e-11
Identities = 61/213 (28%), Positives = 98/213 (45%), Gaps = 13/213 (6%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTG S G+G V +EL G V+ CAR ++E E+ G DVS++
Sbjct: 21 ALVTGGSKGLGEAVVEELAMLGARVHTCARDETQLQERLREWQAKGFEVTTSVCDVSSRE 80
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+L ++ + KL++L NNAG P+ + + E N+ + +
Sbjct: 81 QREKL-METVSSVFQGKLNILVNNAGTGIIKPSTEYTAEDYSFLMATNLESAFHLSQIAH 139
Query: 124 PLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
PL+ + G+IVF S+AG+ ++Y ASK A++Q R L E +RV ++
Sbjct: 140 PLLKASGSGSIVFMSSVAGLV-HTGASIYGASKGAMNQLGRSLACEWASDNIRVNSVCPW 198
Query: 183 GVATDIADKKTLPEGSIFNFPEGIKAVETRKKM 215
+ T + IF+ + KAVE + M
Sbjct: 199 VITTPLT-------SFIFSDEKLRKAVEDKTPM 224
>Hs7706318 [Q] KOG1205 Predicted dehydrogenase
Length = 339
Score = 65.9 bits (159), Expect = 7e-11
Identities = 57/201 (28%), Positives = 88/201 (43%), Gaps = 19/201 (9%)
Query: 9 VTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPR-----------KL 57
VTGASSGIG E+ +L + G + ARR H +E ++ RC+ L
Sbjct: 55 VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKR----RCLENGNLKEKDILVLPL 110
Query: 58 DVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPIN 117
D+++ + QE ++ +L NN G S +D S ++ +N G ++
Sbjct: 111 DLTDTGSHEAATKAVLQEF--GRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVS 168
Query: 118 SCREFAPLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPL-GVR 175
+ P +I K G IV S+ GI P Y ASK A+ + L EL G+
Sbjct: 169 LTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGII 228
Query: 176 VINMITGGVATDIADKKTLPE 196
V N+ G V ++I + E
Sbjct: 229 VSNICPGPVQSNIVENSLAGE 249
>7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 339
Score = 65.9 bits (159), Expect = 7e-11
Identities = 64/227 (28%), Positives = 109/227 (47%), Gaps = 16/227 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPM----EELRAEFGDRCIPRKLDVS 60
++A+VTGA+ GIG E +EL R+G + +R + E+ +++ + D +
Sbjct: 71 QWAVVTGATDGIGKEYARELARQGINLVLISRTKEKLIAVTNEIESQYKVKTKWIAADFA 130
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLP-AID-VSEEIIDNTFRVNVYGPINS 118
++ ++E+EL + +L NN G P ++D VSE+++ N VN+
Sbjct: 131 KGREVYD---QIEKELAGIDVGILVNNVGMMYEHPESLDLVSEDLLWNLLTVNMGSVTML 187
Query: 119 CREFAPLII-NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
R+ P +I KG IV GS + + P P VY+ASK + +++ L E+ + V
Sbjct: 188 TRKILPQMIGRRKGAIVNLGSSSELQPLPNMTVYAASKKFVTYFSKALELEVAEHNIHVQ 247
Query: 178 NMITGGVATDI-ADKKTLPEGSIFNFPEGI----KAVETRKKMSEKN 219
++ V T + A + +G +F FP AV T K SE N
Sbjct: 248 LVMPNFVVTKMNAYTDRVMQGGLF-FPNAYTFARSAVFTLGKTSETN 293
>CE26808_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 550
Score = 65.9 bits (159), Expect = 7e-11
Identities = 61/207 (29%), Positives = 91/207 (43%), Gaps = 15/207 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRK------LD 58
K ALVTG+S+GIG ++G V R +EE R +P + D
Sbjct: 222 KVALVTGSSNGIGRAAALLFAQQGAKVTITGRNAERLEETRQAILKSGVPAENVLAIAAD 281
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLP----AIDVSEEIIDNTFRVNVYG 114
++ T L Q+ +L +L NNAG + + P ID E D TF++N+
Sbjct: 282 LATDQGQTDLINGTLQKFG--RLDILVNNAGAAVNDPQGRMGIDQQIEDFDKTFQINMRS 339
Query: 115 PINSCREFAPLIINAKGTIVFTGSLAGICPF--PFGAVYSASKAAIHQYARVLHGELGPL 172
+ ++ +I KG I+ S+ G P P Y SKAA+ Q+ R L
Sbjct: 340 VVTLVQKAKEHLIKTKGEIINVSSIGG-GPHAQPDMMYYGMSKAALDQFTRSTAITLIQH 398
Query: 173 GVRVINMITGGVATDIADKKTLPEGSI 199
GVRV ++ GGV T + P G++
Sbjct: 399 GVRVNSVSPGGVYTGFGEAMGFPPGAL 425
>At3g47360 [Q] KOG1205 Predicted dehydrogenase
Length = 309
Score = 65.5 bits (158), Expect = 9e-11
Identities = 64/208 (30%), Positives = 97/208 (45%), Gaps = 9/208 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPME---ELRAEFGD-RCIPRKLDVS 60
K L+TGASSGIG V E ++G Y+ ARR +E E + G I DVS
Sbjct: 48 KVVLITGASSGIGEHVAYEYAKKGAYLALVARRRDRLEIVAETSRQLGSGNVIIIPGDVS 107
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSE-EIIDNTFRVNVYGPINSC 119
N D K E KL L NNAG ++ D ++ + + +N +G
Sbjct: 108 NVEDCK--KFIDETIRHFGKLDHLINNAGVFQTVLFEDFTQIQDANPIMDINFWGTTYIT 165
Query: 120 REFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
P + +KG IV S + P P ++Y+ASKAA+ ++ L EL P +++ +
Sbjct: 166 YFAIPHLRKSKGKIVAITSGSANIPLPLASIYAASKAALLRFFETLRIELSP-DIKITIV 224
Query: 180 ITGGVATDIADKKTLPE-GSIFNFPEGI 206
+ G V+TD+ + + GS F E +
Sbjct: 225 LPGVVSTDMTTPHCIEKYGSDFILSESV 252
>At2g30670 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 65.5 bits (158), Expect = 9e-11
Identities = 50/187 (26%), Positives = 92/187 (48%), Gaps = 5/187 (2%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTG +SGIG+ + +EL G +Y C + + +E+ G + DVS+ +
Sbjct: 12 ALVTGGASGIGHAIVEELAGLGARIYVCDISETLLNQSLSEWEKKGFQVSGSICDVSSHS 71
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+ L ++ ++ D KL++L NN G P I+ + N+ + +
Sbjct: 72 ERETL-MQTVSKMFDGKLNILVNNVGVVNPKPTIEYVAADFSFSISTNLESAYHLSQLSH 130
Query: 124 PLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
PL+ ++ G+I+F S+ G+ G++YS +K A++Q A+ L E G+R ++
Sbjct: 131 PLLKASEFGSIIFISSVGGVVSMECGSIYSLTKGALNQLAKTLACEWARDGIRANSVAPN 190
Query: 183 GVATDIA 189
+ T +A
Sbjct: 191 FIYTAMA 197
>7301818 [Q] KOG1205 Predicted dehydrogenase
Length = 326
Score = 65.5 bits (158), Expect = 9e-11
Identities = 73/281 (25%), Positives = 111/281 (38%), Gaps = 32/281 (11%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K L+TGASSG+G + R G V ARRT +E ++ + LDV
Sbjct: 54 KVVLITGASSGLGESLAHVFYRAGCRVILAARRTQELERVKKDL------LALDVDPAYP 107
Query: 65 ITQLKLKLEQ--ELPD---------QKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVY 113
T L L L + +P+ ++ +L NN G S + ++ VN +
Sbjct: 108 PTVLPLDLAELNSIPEFVTRVLAVYNQVDILINNGGISVRADVASTAVDVDLKVMVVNYF 167
Query: 114 GPINSCREFAP-LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPL 172
G + + P ++ G I F S+ G P A YSASK A+ +A L E+
Sbjct: 168 GSVALTKALLPSMVKRGSGHICFISSVQGKFAIPQRAAYSASKHAMQAFADSLRAEVANK 227
Query: 173 GVRVINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARETV 232
+ V + G + T ++ GS + K ET K MSP A +
Sbjct: 228 NINVSCVSPGYIRTQLSLNALTGSGSSYG-----KVDETTAK------GMSPDKLAERIL 276
Query: 233 NDIENGSIDPVDIYRGTMATVVKWLMLLIPYALLEWGLRKK 273
I +P I A + +L L P +L W + K+
Sbjct: 277 QCILRK--EPDIIVSDVQAKIAYYLRHLCP-SLYFWIMAKR 314
>Hs5031737 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 65.1 bits (157), Expect = 1e-10
Identities = 52/189 (27%), Positives = 86/189 (44%), Gaps = 6/189 (3%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSN 61
+ A+VTG++SGIG+ + + L R G +V +R+ ++ A+ G V
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGK 96
Query: 62 QNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPA-IDVSEEIIDNTFRVNVYGPINSCR 120
D QL K + + L +AG + + + + SE+I D VNV P
Sbjct: 97 AEDREQLVAKALEHCGG--VDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
Query: 121 EFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMI 180
+ P + N +G ++ S+A P VY+ SK A+ R L EL P +RV ++
Sbjct: 155 QLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVV 214
Query: 181 TGGVATDIA 189
G + TD +
Sbjct: 215 PGIIKTDFS 223
>7296704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 65.1 bits (157), Expect = 1e-10
Identities = 64/247 (25%), Positives = 99/247 (39%), Gaps = 12/247 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCI-----PRKL-- 57
K L+TGA+SGIG + + G AC EE RC+ P +
Sbjct: 14 KVVLITGAASGIGAAAAEMFSKLG----ACLALVDREEEGLICVMKRCMKMGHEPYGIAG 69
Query: 58 DVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPIN 117
D+ +I + K + + KL +L N AG + + NV
Sbjct: 70 DLLKPPEIECIARKTTERY-EGKLDVLVNGAGIMPTGTLQSTELACFTHVMEANVRSGFY 128
Query: 118 SCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
+ P ++ KG+IV S+ G+ FP Y+ SKAA+ Q+ R L +LGP GVRV
Sbjct: 129 LTKLLLPQLLQCKGSIVNVSSVCGLRAFPNLVAYNMSKAAVDQFTRSLALDLGPQGVRVN 188
Query: 178 NMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARETVNDIEN 237
+ G + T++ + E S F E K ++ E + + + +
Sbjct: 189 AVNPGVIRTNLQKAGGMDEQSYAEFLEHSKKTHALGRIGEPKEVAAAICFLASELASFVT 248
Query: 238 GSIDPVD 244
G PVD
Sbjct: 249 GVTLPVD 255
>7295487 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 317
Score = 65.1 bits (157), Expect = 1e-10
Identities = 58/211 (27%), Positives = 96/211 (45%), Gaps = 13/211 (6%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIP---RKLDVSN 61
K A+VT ++ GIG+ + K L G V +R+ ++ AE + K VS
Sbjct: 72 KVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHVSE 131
Query: 62 QNDITQLKLKLEQELPD-QKLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYGPINSC 119
D QL E+ + KL++L +NA + ++ + + E++ D F VNV
Sbjct: 132 PEDRKQL---FEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKSSYLLA 188
Query: 120 REFAPLIINAKGT-IVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVIN 178
+E PL+ K + IVF S+AG F YS SK A+ + +L P G+RV
Sbjct: 189 KEALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNC 248
Query: 179 MITGGVATDIA----DKKTLPEGSIFNFPEG 205
+ G + T + + ++ E ++ P G
Sbjct: 249 LAPGVIRTKFSKALYENESANEAALSKIPMG 279
>YIR036c [Q] KOG1204 Predicted dehydrogenase
Length = 263
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/234 (27%), Positives = 110/234 (46%), Gaps = 18/234 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRG--WYVYACARRTHPMEELRAEFG-DRCIPRKLDVSN 61
K L+TGAS GIG ++ K ++ VY AR ++ L+ E+G D+ + R LD+++
Sbjct: 3 KVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQREYGADKFVYRVLDITD 62
Query: 62 QNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIID-----NTFRVNVYGPI 116
++ + L ++ Q+ KL + NAG + +I S D F VN + +
Sbjct: 63 RSRMEALVEEIRQK--HGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIV 120
Query: 117 NSCREFAPLIINAK--GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGV 174
+ PL+ ++ G IVF S A + P+ + Y SKAA++ +A + E V
Sbjct: 121 SLVALCLPLLKSSPFVGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKV 180
Query: 175 RVINMITGGVATDIAD--KKTL-PEGSIFNFPEGIKAVETRKKMSEKNQPMSPA 225
R + + G V T + ++TL P+G P+ ++ K S P PA
Sbjct: 181 RAVCIAPGVVDTQMQKDIRETLGPQGMT---PKALERFTQLYKTSSLLDPKVPA 231
>SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 64.7 bits (156), Expect = 2e-10
Identities = 61/200 (30%), Positives = 101/200 (50%), Gaps = 11/200 (5%)
Query: 1 MSET-KYALVTGASSGIGYEVTKELL-RRGWYVYACARRTHPMEELR--AEFGDRCIPRK 56
MS T K + G + GIG + KEL R+G V+A AR+ +L+ ++ K
Sbjct: 1 MSTTNKIYFIAGGNRGIGLSLVKELSNRKGTVVFASARKPGAATKLQEWSKSHSNVHIIK 60
Query: 57 LDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSL-PAIDVSEEIIDNTFRVNVYGP 115
LDVS+ + ++ + + + +L+ N+ S P ++ +++ ++ ++ NV GP
Sbjct: 61 LDVSSLESANEAAQEVTKVV--DAVDVLWVNSAVFHSFGPVVNTPDDVWNSHYKTNVLGP 118
Query: 116 INSCREFAPLIINAKG-TIVFTGSLAGICP--FPFG-AVYSASKAAIHQYARVLHGELGP 171
I+ + F PLI + IVFT SLAG FP + Y SKAA++ + + EL
Sbjct: 119 IHVYQAFYPLIKKGRSKIIVFTSSLAGSMGAFFPSSQSAYGQSKAALNYTMKEISFELQD 178
Query: 172 LGVRVINMITGGVATDIADK 191
G VI++ G V TD A +
Sbjct: 179 EGFIVISIHPGAVRTDSAQE 198
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 64.7 bits (156), Expect = 2e-10
Identities = 56/191 (29%), Positives = 87/191 (45%), Gaps = 9/191 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K A++TG+S+GIG + L G V R +EE + +P + D
Sbjct: 7 KVAIITGSSNGIGQATARLLASEGAKVTVTGRNAERLEETKNILLGAGVPEGNVLVVVGD 66
Query: 65 ITQLKLK--LEQELPDQ--KLHLLYNNAGQSC----SLPAIDVSEEIIDNTFRVNVYGPI 116
ITQ ++ L + D+ K+ +L NNAG ++ S + TF +NV I
Sbjct: 67 ITQESVQENLIKSTLDKFGKIDILVNNAGAGIPDAQGKSGVNQSIDTYHKTFELNVQSVI 126
Query: 117 NSCREFAPLIINAKGTIVFTGSL-AGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
++ P + +G IV S+ AG YS +KAA+ QY R +L P G+R
Sbjct: 127 EMTQKARPHLAKTQGEIVNISSIGAGPAAQVASPYYSIAKAALDQYTRTAAIDLVPEGIR 186
Query: 176 VINMITGGVAT 186
V ++ G V+T
Sbjct: 187 VNSVSPGAVST 197
>At4g03140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 283
Score = 64.7 bits (156), Expect = 2e-10
Identities = 52/177 (29%), Positives = 77/177 (43%), Gaps = 5/177 (2%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ 62
E K AL+TG +SGIG + + G V + E E G C DV+ +
Sbjct: 19 EGKVALITGGASGIGKATAGKFISHGAKVIIADIQPQIGRETEQELGPSCAYFPCDVTKE 78
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLP--AIDVSEEIIDNTFRVNVYGPINSCR 120
+DI + L KL ++YNNAG C P +D+ + D NV G + +
Sbjct: 79 SDIAN-AVDFAVSL-HTKLDIMYNNAGIPCKTPPSIVDLDLNVFDKVINTNVRGVMAGIK 136
Query: 121 EFAPLII-NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRV 176
A ++I G+I+ GS+ G+ YS SK+A+ R EL +RV
Sbjct: 137 HAARVMIPRNSGSIICAGSVTGMMGGLAQHTYSVSKSAVIGIVRSTASELCKHRIRV 193
>At3g26770 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 64.7 bits (156), Expect = 2e-10
Identities = 61/217 (28%), Positives = 99/217 (45%), Gaps = 15/217 (6%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ 62
E K AL+TG +SG+G E LR G V + E G + DV+ +
Sbjct: 16 EGKVALITGGASGLGKATASEFLRHGARVVIADLDAETGTKTAKELGSEAEFVRCDVTVE 75
Query: 63 NDIT-QLKLKLEQELPDQKLHLLYNNAG-----QSCSLPAIDVSEEIIDNTFRVNVYGPI 116
DI +++ +E+ KL ++YNNAG S+ +D++E + R+NV+G +
Sbjct: 76 ADIAGAVEMTVERY---GKLDVMYNNAGIVGPMTPASISQLDMTE--FERVMRINVFGVV 130
Query: 117 NSCREFAPLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
+ + A +I A+ G I+ T S+AG+ Y+ SK + EL GVR
Sbjct: 131 SGIKHAAKFMIPARSGCILCTSSVAGVTGGLAPHSYTISKFTTPGIVKSAASELCEHGVR 190
Query: 176 VINMITGGVATDIA---DKKTLPEGSIFNFPEGIKAV 209
+ + G VAT + +K P+ S E +K +
Sbjct: 191 INCISPGTVATPLTLSYLQKVFPKVSEEKLRETVKGM 227
>At2g29330 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 64.7 bits (156), Expect = 2e-10
Identities = 56/199 (28%), Positives = 91/199 (45%), Gaps = 7/199 (3%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTG +SGIG+ + +EL G ++ C + + +E+ G + D SN+
Sbjct: 12 ALVTGGASGIGHAIVEELAGFGAKIHVCDISKTLLNQSLSEWEKKGFQVSGSVCDASNRL 71
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+ L ++ + D KL++L NN G + P I+ E N+ + +
Sbjct: 72 ERETL-MQTVTTIFDGKLNILVNNVGTIRTKPTIEYEAEDFSFLISTNLESAYHLSQLSH 130
Query: 124 PLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
PL+ + G I F S AGI F ++Y +K A++Q AR L E G+R +
Sbjct: 131 PLLKASGNGIITFISSAAGIVSFDAASIYGLTKGALNQLARNLACEWAKDGIRANAVAPN 190
Query: 183 GVATDIADKKTLPEGSIFN 201
+ T +A K E + FN
Sbjct: 191 FITTALA--KPFLEDAGFN 207
>At2g29310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 64.7 bits (156), Expect = 2e-10
Identities = 54/188 (28%), Positives = 89/188 (46%), Gaps = 7/188 (3%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTGA+SGIGY + +EL G ++ C + + +E+ G + DV+++
Sbjct: 12 ALVTGAASGIGYAIVEELASFGAIIHICDISETLLSQSLSEWEKKGFQVSGSICDVASRP 71
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
D +L ++ L D KL++L NN G P + E N+ P + +
Sbjct: 72 DREKL-MQTVSSLFDGKLNILVNNVGVIRGKPTTEYVAEDFSYHISTNL-EPAFHFSQLS 129
Query: 124 PLIINAK--GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMIT 181
L++ A G+IVF S G+ G++YS +K A++Q R L E G+R +
Sbjct: 130 HLLLKASGFGSIVFMSSATGVVSVQCGSIYSLTKGALNQLTRNLACEWAKDGIRANAVAP 189
Query: 182 GGVATDIA 189
V T ++
Sbjct: 190 NVVKTPLS 197
>At1g10310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 242
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/203 (29%), Positives = 93/203 (45%), Gaps = 11/203 (5%)
Query: 8 LVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRC--IPRKLDVSNQNDI 65
L+TG S G+G + EL +RG V CAR + L++E + DV + + +
Sbjct: 21 LITGVSKGLGRALALELAKRGHTVIGCARSQEKLTALQSELSSSTNHLLLTADVKSNSSV 80
Query: 66 TQLKLKLEQE--LPDQKLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYGPINSCREF 122
++ + ++ +PD ++ NNAG I +VS E DN NV G N R F
Sbjct: 81 EEMAHTIVEKKGVPD----IIVNNAGTINKNSKIWEVSAEDFDNVMDTNVKGVANVLRHF 136
Query: 123 APLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMIT 181
PL++ K G IV S G A Y ASK AI +R + E+ G+ V+ +
Sbjct: 137 IPLMLPRKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKEVVE-GMAVVALNP 195
Query: 182 GGVATDIADKKTLPEGSIFNFPE 204
G + T++ S++ P+
Sbjct: 196 GVINTELLTSCFGNSASLYQAPD 218
>Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 319
Score = 64.3 bits (155), Expect = 2e-10
Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 2/187 (1%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
KY +TG SG G + ++G++V A L+AE +R LDV++ +
Sbjct: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPEN 89
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAID-VSEEIIDNTFRVNVYGPINSCREFA 123
+ + ++ ++ ++ L L NNAG L D ++ E VN++G I+
Sbjct: 90 VKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNML 149
Query: 124 PLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGG 183
PL+ A+G ++ S+ G G Y+ SK A+ + L ++ GV V + G
Sbjct: 150 PLVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGL 208
Query: 184 VATDIAD 190
T++AD
Sbjct: 209 FKTNLAD 215
>CE12594 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 64.3 bits (155), Expect = 2e-10
Identities = 56/204 (27%), Positives = 88/204 (42%), Gaps = 17/204 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRK-------- 56
K ++TG+SSGIG + G V R +EE R + +P +
Sbjct: 7 KSIIITGSSSGIGRSAAVIFAKEGAQVTITGRSADRLEETRLQILKAGVPAEKINAVVAD 66
Query: 57 -LDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCS--LPAIDVSEEIIDNTFRVNVY 113
+ S Q+++ + L K+ +L NNAG + D + E+ TF++N
Sbjct: 67 VCEASGQDEVIRTTLA-----KFGKIDILVNNAGALLTDGTSNTDQAVELYQKTFKLNFQ 121
Query: 114 GPINSCREFAPLIINAKGTIVFTGSL-AGICPFPFGAVYSASKAAIHQYARVLHGELGPL 172
+ ++ +I KG IV S+ AG P Y+ +KAA+ QY R +L
Sbjct: 122 AVVEMTQKTKEYLIKTKGEIVNVSSIVAGPQAQPASPYYACAKAALDQYTRCTAIDLIQH 181
Query: 173 GVRVINMITGGVATDIADKKTLPE 196
GVRV ++ G +AT LPE
Sbjct: 182 GVRVNSVSPGVIATGFLGAMGLPE 205
>7290988 [Q] KOG1205 Predicted dehydrogenase
Length = 249
Score = 64.3 bits (155), Expect = 2e-10
Identities = 62/206 (30%), Positives = 98/206 (47%), Gaps = 18/206 (8%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELR----AEFGDRCIPRKLD 58
+ + A+++GASSGIG + L+ G V ARRT +E+LR AE R K D
Sbjct: 5 QNRVAVISGASSGIGAACARLLVAAGLQVVGLARRTDRLEQLRQSLPAEQRMRFHQHKCD 64
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINS 118
VS + + +E+EL + +L NNAG ID+ + I+N + N+ G I
Sbjct: 65 VSQELQVDTAFEWIEKELGG--IDVLINNAGIVLGGQLIDMPTKDINNILQTNLMGSI-Y 121
Query: 119 CREFAPLIINAK---GTIVFTGSLAGICPF-PFGA-----VYSASKAAIHQYARVLHGEL 169
C + A + + G ++F S AG+ + P A Y+ SK A+ + EL
Sbjct: 122 CTKLAASSMRRRQVAGHLIFVNSTAGVAGYKPDPADESLNAYTPSKFALTAVQEICRQEL 181
Query: 170 GPLG--VRVINMITGGVATDIADKKT 193
G ++ ++ G VAT+I +T
Sbjct: 182 INQGSKIKTTSINPGWVATEIVPDET 207
>SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 63.9 bits (154), Expect = 3e-10
Identities = 61/200 (30%), Positives = 101/200 (50%), Gaps = 11/200 (5%)
Query: 1 MSET-KYALVTGASSGIGYEVTKELLRR-GWYVYACARRTHPMEELR--AEFGDRCIPRK 56
MS T K + G + GIG + KEL R G V+A AR+ EL+ ++ K
Sbjct: 1 MSTTNKIYFIAGGNRGIGLSLVKELSNREGTVVFASARKPEAATELQEWSKSHSNVHIIK 60
Query: 57 LDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYGP 115
LD+S+ + ++ + + K+ +L+ N+G S + + +++ ++ ++ NV GP
Sbjct: 61 LDISSLESANEAAQEVAKAVG--KVDVLWVNSGIFHSFNTVLNTPDDVWNSHYKTNVLGP 118
Query: 116 INSCREFAPLIINAKG-TIVFTGSLAGICP--FPFG-AVYSASKAAIHQYARVLHGELGP 171
I+ + F PL+ + IVFT SL G FPF + Y SKAA++ + + EL
Sbjct: 119 IHVYQAFYPLVKKGESKIIVFTSSLVGSMGAFFPFNQSGYGQSKAALNFTMKEISFELQD 178
Query: 172 LGVRVINMITGGVATDIADK 191
G VI++ G V TD A +
Sbjct: 179 EGFIVISIHPGMVRTDSAQE 198
>Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 313
Score = 63.9 bits (154), Expect = 3e-10
Identities = 52/191 (27%), Positives = 81/191 (42%), Gaps = 2/191 (1%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
KY +TG SG G + K+L+ RG V A ++L+ + R LDV+
Sbjct: 26 KYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKSES 85
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSC-SLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
I + ++ +Q L L NNAG S P ++++ VN+ G I
Sbjct: 86 IKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEVTLHML 145
Query: 124 PLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGG 183
P++ A+G +V S G G Y SK + ++ + EL GV+V + G
Sbjct: 146 PMVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRRELYYFGVKVCIIEPGN 204
Query: 184 VATDIADKKTL 194
T I K+ L
Sbjct: 205 YRTAILGKENL 215
>CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 347
Score = 63.9 bits (154), Expect = 3e-10
Identities = 64/248 (25%), Positives = 106/248 (41%), Gaps = 29/248 (11%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---------GDRCIPR 55
++A+VTG S GIG+++ L+ RG +V AR +E+ A+ + +
Sbjct: 39 RHAIVTGGSKGIGFQLAVGLIERGCHVTIVARNVKDLEKACADLQVLADQRGQRQKVHWK 98
Query: 56 KLDVSNQNDITQLKL-KLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYG 114
+D++ D+ + +EL + +L NNAG S P ++ + VN
Sbjct: 99 SIDMTGGYDVIKSAFDDAAREL--GPIDILINNAGHSVQAPFCELPITDFEKQMAVNYLS 156
Query: 115 PINSCREFAPLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
+++ R + K G I F S AG + YS +K A+ +A LH EL P
Sbjct: 157 AVHATRAVVDDMKTRKTGHISFVSSAAGQFAIFGYSAYSPTKFALRGFADTLHMELLPYK 216
Query: 174 VRVINMITGGVATD--IADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARET 231
V V + T+ + +T+PE + KKMSE +P D A
Sbjct: 217 VNVGVLYPPNTDTEGFKVELETMPEET--------------KKMSEAAGLFTPKDVAEAH 262
Query: 232 VNDIENGS 239
+ DI +G+
Sbjct: 263 LKDIADGN 270
>CE12990 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 63.2 bits (152), Expect = 5e-10
Identities = 54/204 (26%), Positives = 90/204 (43%), Gaps = 17/204 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---------GDRCIPR 55
K ++TG+SSGIG + G V R +E + + + +
Sbjct: 7 KSVIITGSSSGIGRATAVLFAKNGAQVTITGRNAEKLEATKKKLLKVVKTPDSVNVVVAN 66
Query: 56 KLDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAI--DVSEEIIDNTFRVNVY 113
D Q+ I Q +K K+ +L NNAG + + D S ++ TF++N
Sbjct: 67 LTDAQGQDQIIQSAVK-----KFGKIDILINNAGANVVDGTVNTDQSIDLYHKTFQINFQ 121
Query: 114 GPINSCREFAPLIINAKGTIVFTGSLA-GICPFPFGAVYSASKAAIHQYARVLHGELGPL 172
+ ++ +I +KG IV S+A G Y+A+KAA++QY R + +L
Sbjct: 122 AVVEMVKKTKKYLIESKGEIVNVSSIAAGPQAVSMSPYYAAAKAALNQYTRCVALDLIKQ 181
Query: 173 GVRVINMITGGVATDIADKKTLPE 196
GVRV ++ G +AT+ +PE
Sbjct: 182 GVRVNSVSPGIIATNFMGAMGVPE 205
>CE11498 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 323
Score = 63.2 bits (152), Expect = 5e-10
Identities = 62/220 (28%), Positives = 97/220 (43%), Gaps = 33/220 (15%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF-------------G 49
+ + ALVTGAS GIG + +L G VY RR + R G
Sbjct: 6 QDQVALVTGASRGIGRGIALQLGEAGATVYITGRRPELSDNFRLGLPSLDYVAKEITSRG 65
Query: 50 DRCIPRKLDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTF- 108
+ I +D SN ++ L K++++ + KL +L NN S + + E+I TF
Sbjct: 66 GKGIALYVDHSNMTEVKFLFEKIKED-EEGKLDILVNNVYNS-----LGKATEMIGKTFF 119
Query: 109 --------RVNVYGPINS--CREFAP--LIINAKGTIVFTGSLAGICPFPFGAVYSASKA 156
+N G N C +A ++ KG IV GSL G+ + F Y A K
Sbjct: 120 DQDPSFWDDINGVGLRNHYYCSVYAARMMVERRKGLIVNVGSLGGL-KYVFNVAYGAGKE 178
Query: 157 AIHQYARVLHGELGPLGVRVINMITGGVATDIADKKTLPE 196
A+ + + + EL P V V+ +I G V T+ A++ + +
Sbjct: 179 ALARMSTDMAVELNPYNVCVVTLIPGPVKTETANRTIIDD 218
>At4g13180 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 263
Score = 63.2 bits (152), Expect = 5e-10
Identities = 61/195 (31%), Positives = 94/195 (47%), Gaps = 14/195 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYA-CARRTHPMEELRAEFGDR-----CIPRKLD 58
+ A+VTGA+ G+G E+ L G V + E L +E D I K D
Sbjct: 16 RVAIVTGATRGMGREIAIHLHSLGARVTINYVSSSSKAELLVSELNDSSQLKSAIAVKAD 75
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQ-SCSLPAI-DVSEEIIDNTFRVNVYGPI 116
VS+ + I L + EQE K+H++ N AG P++ + + E DNTF +N G
Sbjct: 76 VSDPDQINNLFDQTEQEF-GSKVHIVVNCAGVLDPKYPSLSETTLEDFDNTFTINTRGSF 134
Query: 117 NSCREFAPLIINAKG---TIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
C+E A ++ G ++ T + G+ P +G VY+ASKAA+ +VL EL
Sbjct: 135 LCCKEAAKRVMRGGGGRIIMMSTSMVGGLAP-GYG-VYAASKAAVETMVKVLAKELKGSR 192
Query: 174 VRVINMITGGVATDI 188
+ + G VAT++
Sbjct: 193 ITANCVAPGPVATEM 207
>At5g50690 [Q] KOG1205 Predicted dehydrogenase
Length = 303
Score = 62.8 bits (151), Expect = 6e-10
Identities = 58/183 (31%), Positives = 90/183 (48%), Gaps = 16/183 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSN--- 61
K ++TG+SSGIG + E RRG Y+ ARR ++ + DRC RKL +
Sbjct: 48 KVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVV----ADRC--RKLGSPDVAV 101
Query: 62 -QNDITQLK--LKLEQELPDQ--KLHLLYNNAGQSCSLPAIDVSE-EIIDNTFRVNVYGP 115
+ D++ +K + QE + +L L NNAG + + D SE + N +GP
Sbjct: 102 VRGDVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGP 161
Query: 116 INSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGP-LGV 174
+ + P + KG I+ S AG P ++Y+ASKAA+ + L EL P +GV
Sbjct: 162 VYATHFAIPHLKKTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIELHPEVGV 221
Query: 175 RVI 177
++
Sbjct: 222 TIV 224
>At5g50590 [Q] KOG1205 Predicted dehydrogenase
Length = 299
Score = 62.8 bits (151), Expect = 6e-10
Identities = 58/183 (31%), Positives = 90/183 (48%), Gaps = 16/183 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSN--- 61
K ++TG+SSGIG + E RRG Y+ ARR ++ + DRC RKL +
Sbjct: 48 KVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVV----ADRC--RKLGSPDVAV 101
Query: 62 -QNDITQLK--LKLEQELPDQ--KLHLLYNNAGQSCSLPAIDVSE-EIIDNTFRVNVYGP 115
+ D++ +K + QE + +L L NNAG + + D SE + N +GP
Sbjct: 102 VRGDVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGP 161
Query: 116 INSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGP-LGV 174
+ + P + KG I+ S AG P ++Y+ASKAA+ + L EL P +GV
Sbjct: 162 VYATHFAIPHLKKTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIELHPEVGV 221
Query: 175 RVI 177
++
Sbjct: 222 TIV 224
>At3g47350 [Q] KOG1205 Predicted dehydrogenase
Length = 308
Score = 62.8 bits (151), Expect = 6e-10
Identities = 58/192 (30%), Positives = 92/192 (47%), Gaps = 14/192 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPME---ELRAEFGDR---CIPRKLD 58
K L+TGASSGIG V E ++G + ARR +E E + G IP D
Sbjct: 47 KVVLITGASSGIGEHVAYEYAKKGAKLALVARRKDRLEIVAETSRQLGSGDVIIIPG--D 104
Query: 59 VSNQNDITQLKLKLEQELPD-QKLHLLYNNAGQSCSLPAIDVSE-EIIDNTFRVNVYGPI 116
VSN D + +++ + KL L NNAG ++ D ++ + ++ +N +G
Sbjct: 105 VSNVEDCKKF---IDETIHHFGKLDHLINNAGVPQTVIFEDFTQIQDANSIMDINFWGST 161
Query: 117 NSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRV 176
P + +KG IV S I P +VYSASKAA+ ++ L E+ P +++
Sbjct: 162 YITYFAIPHLRKSKGKIVVISSATAIIPLQAASVYSASKAALVKFFETLRVEISP-DIKI 220
Query: 177 INMITGGVATDI 188
+ G ++TD+
Sbjct: 221 TIALPGFISTDM 232
>At2g29360 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 271
Score = 62.8 bits (151), Expect = 6e-10
Identities = 59/213 (27%), Positives = 95/213 (43%), Gaps = 12/213 (5%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACAR-RTHPMEELR--AEFGDRCIPRKLDVSNQN 63
ALVTG S GIG V +EL G ++ CAR T E LR G + DVS+++
Sbjct: 21 ALVTGGSKGIGEAVVEELATLGARIHTCARDETQLQESLRKWQAKGFQVTTSVCDVSSRD 80
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+L ++ + + KL++L NN G P + + E T N+ + +
Sbjct: 81 KREKL-METVSTIFEGKLNILVNNVGTCIVKPTLQHTAEDFSFTMATNLESAFHLSQLAH 139
Query: 124 PLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
PL+ + G+IV S++G+ ++Y SK A++Q R L E +R ++
Sbjct: 140 PLLKASGSGSIVLISSVSGVVHVNGASIYGVSKGAMNQLGRNLACEWASDNIRTNSVCPW 199
Query: 183 GVATDIADKKTLPEGSIFNFPEGIKAVETRKKM 215
+ T + + E E K VE+R M
Sbjct: 200 FIETPLVTESLSNE-------EFRKEVESRPPM 225
>CE21092 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 62.4 bits (150), Expect = 8e-10
Identities = 57/198 (28%), Positives = 90/198 (44%), Gaps = 21/198 (10%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K A++TG+SSGIG L + G V R + ++E E K S+ N
Sbjct: 7 KVAIITGSSSGIGRSTAVLLAQEGAKVTVTGRSSEKIQETVNEI------HKNGGSSDNI 60
Query: 65 ITQLKLKLEQELPDQ----------KLHLLYNNAGQSCSLPAIDVSEE----IIDNTFRV 110
L E E D+ K+ +L NNAG + + P+ + E I D+ ++
Sbjct: 61 NIVLGDLNESECQDELIKSTLSRFGKIDILINNAGAAFADPSGKIGSEAAIGIFDDMMKL 120
Query: 111 NVYGPINSCREFAPLIINAKGTIVFTGSL-AGICPFPFGAVYSASKAAIHQYARVLHGEL 169
N+ + ++ P +I +KG IV S+ AG P+ + Y KA + Q R L EL
Sbjct: 121 NLRSVVELVKKCRPHLIASKGEIVNVSSIAAGPQPYIYYTYYGICKAGLDQLTRSLALEL 180
Query: 170 GPLGVRVINMITGGVATD 187
P VRV ++ G ++T+
Sbjct: 181 IPFDVRVNSVSPGLISTN 198
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 62.4 bits (150), Expect = 8e-10
Identities = 66/231 (28%), Positives = 97/231 (41%), Gaps = 9/231 (3%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K A++TG+S+GIG R G V R +EE R + + + S D
Sbjct: 7 KVAIITGSSNGIGRATAVLFAREGAKVTITGRHAERLEETRQQILAAGVSEQNVNSVVAD 66
Query: 65 IT----QLKLKLEQELPDQKLHLLYNNAG----QSCSLPAIDVSEEIIDNTFRVNVYGPI 116
+T Q ++ KL +L NNAG S S S E D T +N+ I
Sbjct: 67 VTTDAGQDEILSTTLGKFGKLDILVNNAGAAIPDSQSKTGTAQSIESYDATLNLNLRSVI 126
Query: 117 NSCREFAPLIINAKGTIVFTGSLA-GICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
++ P + + KG IV S+A G+ P YS +KAAI QY R +L G+R
Sbjct: 127 ALTKKAVPHLSSTKGEIVNISSIASGLHATPDFPYYSIAKAAIDQYTRNTAIDLIQHGIR 186
Query: 176 VINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPAD 226
V ++ G VAT +PE + F + ++ QP A+
Sbjct: 187 VNSISPGLVATGFGSAMGMPEETSKKFYSTMATMKECVPAGVMGQPQDIAE 237
>At2g29370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 62.4 bits (150), Expect = 8e-10
Identities = 59/221 (26%), Positives = 99/221 (44%), Gaps = 9/221 (4%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTG S G+G V +EL G V+ CAR ++E E+ G + DVS+++
Sbjct: 21 ALVTGGSKGLGKAVVEELAMLGARVHTCARDETQLQESLREWQAKGLQVTTSVCDVSSRD 80
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+L ++ L KL +L N G P + + E N+ + +
Sbjct: 81 QREKL-METVSSLFQGKLSILVPNVGIGVLKPTTECTAEEFSFIIATNLESTFHFSQLAH 139
Query: 124 PLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
PL+ + G IV S+AG+ ++Y A+K A++Q AR L E +R N +
Sbjct: 140 PLLKASGSGNIVLMSSVAGVVNLGNTSIYGATKGAMNQLARNLACEWASDNIRA-NSVCP 198
Query: 183 GVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMS 223
T + K L + + E +++V +++ E N+ S
Sbjct: 199 WFITTPSTKDFLGDKDV---KEKVESVTPLRRVGEANEVSS 236
>At2g29320 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 62.4 bits (150), Expect = 8e-10
Identities = 53/176 (30%), Positives = 89/176 (50%), Gaps = 10/176 (5%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTGA+SGIGY + +EL G ++ C + + +E+ G + DV++
Sbjct: 18 ALVTGAASGIGYAIVEELAGFGAKIHICDISKTLLNQSLSEWENKGFQVSGSVCDVTSHP 77
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRV--NVYGPINSCRE 121
+ +L ++ + D KL++L NN G P + + D TF + N+ + C+
Sbjct: 78 EREKL-MQTVSSIFDGKLNILVNNVGVLRGKPTTEYVAD--DFTFHISTNLEAAYHFCQL 134
Query: 122 FAPLI-INAKGTIVFTGSLAGICP-FPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
PL+ + G+IVF S+AG+ G++Y +K A++Q AR L E G+R
Sbjct: 135 SHPLLKASGYGSIVFLSSVAGVVSLIDCGSIYGLTKGALNQLARNLACEWAKDGIR 190
>SPCC24B10.20 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 254
Score = 62.0 bits (149), Expect = 1e-09
Identities = 65/239 (27%), Positives = 116/239 (48%), Gaps = 22/239 (9%)
Query: 8 LVTGASSGIGYEVTKELLRR-GWYVYACARRTHPMEELR--AEFGDRCIPRKLDVSNQND 64
++ G + GIG + KEL + G V+A AR EL+ ++ KLDV++
Sbjct: 10 VIVGGNRGIGLSLVKELSNKEGVTVFASARGPGSASELKDWSKTHSNVHIIKLDVTSLRS 69
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSCSL-PAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+++E+ + + + +L+ N+G S S P + S+E+ + ++ NV GPI+ + F
Sbjct: 70 AKDAAMQVEKVV--KCIDVLWVNSGISKSFQPVLKTSDELWMSHYQTNVLGPIHVYQAFY 127
Query: 124 PLIINAK-GTIVFTGSLA----GICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVIN 178
L+ K IVFT S+A G+ P + A Y SKAA++ + + EL G V++
Sbjct: 128 HLLKEGKLKNIVFTSSMAACMGGVRPNTYSA-YGQSKAALNYTMKEISFELEKDGFVVVS 186
Query: 179 MITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARETVNDIEN 237
+ G V TD+ S +PE ++++ K+ +SP A + ++N
Sbjct: 187 IHPGVVNTDMFVNAMQKLAS--KYPEMVESI--------KSNAISPEQSASSMLKIVDN 235
>SPAC977.08 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 61.6 bits (148), Expect = 1e-09
Identities = 41/134 (30%), Positives = 67/134 (49%), Gaps = 5/134 (3%)
Query: 56 KLDVSNQNDITQLKLKLEQELPD-QKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYG 114
+LDV+N + +K +E+ + ++ +L NNAG S P +EE I N F NV+G
Sbjct: 20 QLDVNN---FSSIKKSVEKAISHFGRIDVLLNNAGYSVYSPLESTTEEQIHNIFNTNVFG 76
Query: 115 PINSCREFAPLIINA-KGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
+ + P+ + G I+ S+ G FP G +Y +K AI + L E+ +G
Sbjct: 77 ALEVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIG 136
Query: 174 VRVINMITGGVATD 187
V+V + G AT+
Sbjct: 137 VKVKIIEPGFTATE 150
>SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 61.6 bits (148), Expect = 1e-09
Identities = 41/134 (30%), Positives = 67/134 (49%), Gaps = 5/134 (3%)
Query: 56 KLDVSNQNDITQLKLKLEQELPD-QKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYG 114
+LDV+N + +K +E+ + ++ +L NNAG S P +EE I N F NV+G
Sbjct: 20 QLDVNN---FSSIKKSVEKAISHFGRIDVLLNNAGYSVYSPLESTTEEQIHNIFNTNVFG 76
Query: 115 PINSCREFAPLIINA-KGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
+ + P+ + G I+ S+ G FP G +Y +K AI + L E+ +G
Sbjct: 77 ALEVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIG 136
Query: 174 VRVINMITGGVATD 187
V+V + G AT+
Sbjct: 137 VKVKIIEPGFTATE 150
>CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 368
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/196 (25%), Positives = 88/196 (44%), Gaps = 12/196 (6%)
Query: 9 VTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF------GDRCIPRKLDVSNQ 62
+TG SG G + + L +G V+A +E L AE G +DV++
Sbjct: 74 ITGCDSGFGRGLALKCLEQGMPVFAGCLTEQGIESLSAEARKSIGNGRSLDAFLMDVTSD 133
Query: 63 NDITQLKLKLEQELPDQK-LHLLYNNAGQSCSLPA---IDVSEEIIDNTFRVNVYGPINS 118
+ ++ +LE++ LH + NNAG + A +D++E + +N++GPI +
Sbjct: 134 ESVGEVAKRLEKKCEQYGGLHAVVNNAGITGKHIADDFLDINEYL--KVANINLWGPIRT 191
Query: 119 CREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVIN 178
L+ A+G +V S+ P YS SK + Y V+ EL P G+ V
Sbjct: 192 TMAVKKLLKKARGRVVTVASICARVGLPGLGPYSVSKYGVSAYCDVIRQELRPFGISVHV 251
Query: 179 MITGGVATDIADKKTL 194
+ G T + +++ +
Sbjct: 252 LEPGFFNTPLINREKI 267
>CE05726 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 61.6 bits (148), Expect = 1e-09
Identities = 56/204 (27%), Positives = 87/204 (42%), Gaps = 17/204 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRK-------- 56
K ++TG+S+GIG + G V R +EE + + +P +
Sbjct: 7 KSVIITGSSNGIGRSAAVIFAKEGAQVTITGRNEDRLEETKQQILKAGVPAEKINAVVAD 66
Query: 57 -LDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSE--EIIDNTFRVNVY 113
+ S Q+DI L K+ +L NNAG + + + + E+ TF++N
Sbjct: 67 VTEASGQDDIINTTLA-----KFGKIDILVNNAGANLADGTANTDQPVELYQKTFKLNFQ 121
Query: 114 GPINSCREFAPLIINAKGTIVFTGSL-AGICPFPFGAVYSASKAAIHQYARVLHGELGPL 172
I ++ +I KG IV S+ AG Y+ +KAA+ QY R +L
Sbjct: 122 AVIEMTQKTKEHLIKTKGEIVNVSSIVAGPQAHSGYPYYACAKAALDQYTRCTAIDLIQH 181
Query: 173 GVRVINMITGGVATDIADKKTLPE 196
GVRV ++ G VAT LPE
Sbjct: 182 GVRVNSVSPGAVATGFMGAMGLPE 205
>At3g42960 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 272
Score = 61.6 bits (148), Expect = 1e-09
Identities = 58/190 (30%), Positives = 92/190 (47%), Gaps = 13/190 (6%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K A++TG + GIG + G YV A L AE C DVS + D
Sbjct: 11 KVAIITGGARGIGAATARLFTENGAYVIV-ADILENEGILVAESIGGCYVH-CDVSKEAD 68
Query: 65 I-TQLKLKLEQELPDQKLHLLYNNAGQSC---SLPAIDVSEEIIDNTFRVNVYGPINSCR 120
+ ++L + ++ +L +++NNAG S S+ +DV ++++ VNV G ++ +
Sbjct: 69 VEAAVELAMRRK---GRLDVMFNNAGMSLNEGSIMGMDV--DMVNKLVSVNVNGVLHGIK 123
Query: 121 EFAPLIINAK--GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVIN 178
A +I G+I+ T S +G+ G Y+ SK AI+ R ELG G+RV +
Sbjct: 124 HAAKAMIKGGRGGSIICTSSSSGLMGGLGGHAYTLSKGAINGVVRTTACELGSHGIRVNS 183
Query: 179 MITGGVATDI 188
+ GV TDI
Sbjct: 184 ISPHGVPTDI 193
>At2g29300 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 263
Score = 61.6 bits (148), Expect = 1e-09
Identities = 53/176 (30%), Positives = 90/176 (51%), Gaps = 10/176 (5%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTGA+SGIGY + +EL G ++ C + + E+ G + DV+++
Sbjct: 12 ALVTGAASGIGYAIVEELAGFGARIHVCDISETLLNQSLREWEKKGFQVSGSVCDVTSRP 71
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRV--NVYGPINSCRE 121
+ +L ++ L D KL++L NN G + P + + D TF + N+ + C+
Sbjct: 72 EREKL-MQTVSSLFDGKLNILVNNVGVLRAKPTTEYVAD--DFTFHISTNLEAAYHFCQL 128
Query: 122 FAPLI-INAKGTIVFTGSLAGICPF-PFGAVYSASKAAIHQYARVLHGELGPLGVR 175
PL+ + G+IVF S++G+ G++Y +K A++Q AR L E G+R
Sbjct: 129 SHPLLKTSGYGSIVFLSSVSGVVSITDCGSLYGLTKGALNQLARNLACEWAKDGIR 184
>CE20725 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 60.5 bits (145), Expect = 3e-09
Identities = 59/234 (25%), Positives = 98/234 (41%), Gaps = 12/234 (5%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K AL+TG+S+GIG ++G V R ++E R E IP + ++ D
Sbjct: 7 KVALITGSSNGIGRAAAILFAQQGAKVTITGRNAERLKETRHEIKKSGIPAENILAIVAD 66
Query: 65 IT----QLKLKLEQELPDQKLHLLYNNAG----QSCSLPAIDVSEEIIDNTFRVNVYGPI 116
+ Q++L + L +L NNAG + +D + DNT ++N+ +
Sbjct: 67 VITDEGQMRLINDTVRKFGHLDILVNNAGGALMDAQGRVGMDQDISVFDNTMQINMRSVV 126
Query: 117 NSCREFAPLIINAKGTIVFTGSL-AGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
++ +I +KG I+ ++ AG P Y SKAA+ Q+ R L GVR
Sbjct: 127 TLVQKAKEHLIKSKGEIINVSAMAAGHHGDPIATFYGMSKAALDQFTRSSAISLIQHGVR 186
Query: 176 VINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYAR 229
V ++ G T + P + I E+ K+ + P D A+
Sbjct: 187 VNSVSPGFTKTGFGEAMGFPP---IAMKKVISFYESHKECAPSGAIAQPGDIAQ 237
>CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 333
Score = 60.5 bits (145), Expect = 3e-09
Identities = 58/207 (28%), Positives = 86/207 (41%), Gaps = 12/207 (5%)
Query: 6 YALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIP---RKLDVSNQ 62
+A+VTGA+ GIG EL RRG+ V +R ++E + E ++ R
Sbjct: 66 WAVVTGATDGIGKAYAFELARRGFNVLLVSRTQSKLDETKKEILEKYSSIEVRTAAFDFT 125
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLP----AIDVSEEIIDNTFRVNVYGPINS 118
N L L ++ +L NN G S P +D E + N +N P
Sbjct: 126 NAAPSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIERLANITTINTLPPTLL 185
Query: 119 CREFAPLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
P ++ K G IV GS AG AVYSA+K + +L E G+ V
Sbjct: 186 SAGILPQMVARKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRKEYEHQGITVQ 245
Query: 178 NMITGGVATDIADKKT----LPEGSIF 200
+ VAT ++ K P+G++F
Sbjct: 246 TIAPMMVATKMSKVKRTSFFTPDGAVF 272
>Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase
Length = 244
Score = 60.1 bits (144), Expect = 4e-09
Identities = 55/191 (28%), Positives = 82/191 (42%), Gaps = 8/191 (4%)
Query: 8 LVTGASSGIGYEVTKELLR---RGWYVYACARRTHPMEEL-RAEFGDRCIPRKLDVSNQN 63
L+TG SSGIG + L + + VYA R L A C P L+ Q
Sbjct: 7 LITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETL-QL 65
Query: 64 DITQLK--LKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCRE 121
D+ K + + + ++ +L NAG P + E+ + + VNV G + +
Sbjct: 66 DVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQA 125
Query: 122 FAP-LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMI 180
F P + G ++ TGS+ G+ PF VY ASK A+ L L P GV + +
Sbjct: 126 FLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIE 185
Query: 181 TGGVATDIADK 191
G V T +K
Sbjct: 186 CGPVHTAFMEK 196
>Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 309
Score = 59.7 bits (143), Expect = 5e-09
Identities = 47/188 (25%), Positives = 87/188 (46%), Gaps = 4/188 (2%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRC-IPRKLDVSNQN 63
++A+V+GA+ GIG +EL RG + +R ++ + + D + + V++ +
Sbjct: 47 RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFS 106
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAI--DVSEEIIDNTFRVNVYGPINSCRE 121
++ L + + L D+ + +L NN G P +SE+ + + VN+
Sbjct: 107 SGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHV 166
Query: 122 FAPLIINAKGTIVFTGSLAGIC-PFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMI 180
P ++ K + T S C P P A +SASKA + ++R L E G+ V ++I
Sbjct: 167 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLI 226
Query: 181 TGGVATDI 188
VA +
Sbjct: 227 PFYVAASM 234
>Hs20149619 [Q] KOG1205 Predicted dehydrogenase
Length = 325
Score = 59.3 bits (142), Expect = 7e-09
Identities = 49/201 (24%), Positives = 84/201 (41%), Gaps = 12/201 (5%)
Query: 8 LVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPR---------KLD 58
++TGA+SG+G E K G + C R +EEL E + D
Sbjct: 56 VITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFD 115
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINS 118
+++ I ++ Q + +L NNAG S +D + ++ N +GP+
Sbjct: 116 LTDSGAIVAAAAEILQCFG--YVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVAL 173
Query: 119 CREFAPLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
+ P +I + G IV S+ G PF + Y+ASK A + L E+ + V
Sbjct: 174 TKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVT 233
Query: 178 NMITGGVATDIADKKTLPEGS 198
+ G + T+++ +GS
Sbjct: 234 VISPGYIHTNLSVNAITADGS 254
>At5g50700 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 59.3 bits (142), Expect = 7e-09
Identities = 75/277 (27%), Positives = 114/277 (41%), Gaps = 27/277 (9%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPME---ELRAEFGD-RCIPRKLDVS 60
K L+TGASSGIG ++ E RG + ARR + +E E+ E G + DVS
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVS 107
Query: 61 NQNDITQLKLKLEQELPD-QKLHLLYNNAGQSCSLPAIDVSEEIIDNT-----FRVNVYG 114
+D ++ ++ + +L L NNAG + I + E I D T N +G
Sbjct: 108 KPDDCRRI---VDDTITHFGRLDHLVNNAG----MTQISMFENIEDITRTKAVLDTNFWG 160
Query: 115 PINSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGV 174
+ + R P + + G IV S A P + Y+ASKAA+ + + ELG G
Sbjct: 161 SVYTTRAALPYLRQSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELG--GD 218
Query: 175 RVINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARETVND 234
I ++T G + L +G F+ G + + M + P A
Sbjct: 219 VHITIVTPGYI-----ESELTQGKYFS---GEGELIVNQDMRDVQVGPFPVASASGCAKS 270
Query: 235 IENGSIDPVDIYRGTMATVVKWLMLLIPYALLEWGLR 271
I NG V +L ++ L+EWG R
Sbjct: 271 IVNGVCRKQRYVTEPSWFKVTYLWKVLCPELIEWGCR 307
>At5g50600 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 59.3 bits (142), Expect = 7e-09
Identities = 75/277 (27%), Positives = 114/277 (41%), Gaps = 27/277 (9%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPME---ELRAEFGD-RCIPRKLDVS 60
K L+TGASSGIG ++ E RG + ARR + +E E+ E G + DVS
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVS 107
Query: 61 NQNDITQLKLKLEQELPD-QKLHLLYNNAGQSCSLPAIDVSEEIIDNT-----FRVNVYG 114
+D ++ ++ + +L L NNAG + I + E I D T N +G
Sbjct: 108 KPDDCRRI---VDDTITHFGRLDHLVNNAG----MTQISMFENIEDITRTKAVLDTNFWG 160
Query: 115 PINSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGV 174
+ + R P + + G IV S A P + Y+ASKAA+ + + ELG G
Sbjct: 161 SVYTTRAALPYLRQSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELG--GD 218
Query: 175 RVINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARETVND 234
I ++T G + L +G F+ G + + M + P A
Sbjct: 219 VHITIVTPGYI-----ESELTQGKYFS---GEGELIVNQDMRDVQVGPFPVASASGCAKS 270
Query: 235 IENGSIDPVDIYRGTMATVVKWLMLLIPYALLEWGLR 271
I NG V +L ++ L+EWG R
Sbjct: 271 IVNGVCRKQRYVTEPSWFKVTYLWKVLCPELIEWGCR 307
>At3g29250 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 59.3 bits (142), Expect = 7e-09
Identities = 55/187 (29%), Positives = 88/187 (46%), Gaps = 8/187 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFG-DRCIPRKLDVSNQN 63
K A++TG +SGIG E + G V + + L G D+ + +V+++
Sbjct: 9 KIAIITGGASGIGAEAVRLFTDHGAKVVIVDIQEELGQNLAVSIGLDKASFYRCNVTDET 68
Query: 64 DITQ-LKLKLEQELPDQKLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYGPINSCRE 121
D+ +K +E+ KL +L++NAG + ++ D+ E D T VNV G +
Sbjct: 69 DVENAVKFTVEKH---GKLDVLFSNAGVLEAFGSVLDLDLEAFDRTMAVNVRGAAAFIKH 125
Query: 122 FAPLII--NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
A ++ +G+IV T S+A P Y+ASK A+ R LG G+RV +
Sbjct: 126 AARSMVASGTRGSIVCTTSIAAEIGGPGPHSYTASKHALLGLIRSACAGLGQYGIRVNGV 185
Query: 180 ITGGVAT 186
GVAT
Sbjct: 186 APYGVAT 192
>7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 321
Score = 59.3 bits (142), Expect = 7e-09
Identities = 46/168 (27%), Positives = 77/168 (45%), Gaps = 7/168 (4%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGD----RCIPRKLDVSNQ 62
A+VTGA G+G ++ EL ++G ++ E+ + D R K +V+N
Sbjct: 55 AVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDIYKVRAKAYKANVTNY 114
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREF 122
+D+ +L K+ +E+ + +L NNAG + + VN+ + F
Sbjct: 115 DDLVELNSKVVEEMGP--VTVLVNNAGVMMHRNMFNPDPADVQLMINVNLTSHFWTKLVF 172
Query: 123 APLIINA-KGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGEL 169
P + KG IV SLAG+ P P+ A Y+ +K+ + R L EL
Sbjct: 173 LPKMKELRKGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMEL 220
>Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 300
Score = 58.5 bits (140), Expect = 1e-08
Identities = 51/171 (29%), Positives = 74/171 (42%), Gaps = 6/171 (3%)
Query: 8 LVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAE---FGDRCIPRKLDVSNQND 64
L+TGA GIG E + + H +EE A+ G + +D SN+ D
Sbjct: 40 LITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNRED 99
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFAP 124
I K++ E+ D + +L NNAG + + I+ TF VNV + + F P
Sbjct: 100 IYSSAKKVKAEIGD--VSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLP 157
Query: 125 LII-NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGV 174
+ N G IV S AG PF Y +SK A + + L EL L +
Sbjct: 158 AMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQI 208
>Hs10337605 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 58.5 bits (140), Expect = 1e-08
Identities = 49/195 (25%), Positives = 89/195 (45%), Gaps = 17/195 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF--------GDRCIPRK 56
K ALVT ++ GIG+ + + L + G +V +R+ +++ A G C K
Sbjct: 15 KVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGK 74
Query: 57 LDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYGP 115
+ ++ + + +KL + +L +NA + ++ DV+EE+ D T +NV P
Sbjct: 75 AE--DRERLVAMAVKLHGGID-----ILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAP 127
Query: 116 INSCREFAP-LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGV 174
+ P + G++V S+A P P + Y+ SK A+ + L EL P +
Sbjct: 128 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNI 187
Query: 175 RVINMITGGVATDIA 189
RV + G + T +
Sbjct: 188 RVNCLAPGLIKTSFS 202
>CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 58.5 bits (140), Expect = 1e-08
Identities = 51/212 (24%), Positives = 89/212 (41%), Gaps = 22/212 (10%)
Query: 5 KYALVTGASSGIGYEVTKELLRRG--WYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ 62
K ++TGA+ GIG + +E ++ ++ A AR +L+A R +L+V+
Sbjct: 4 KSVVITGANRGIGLGLVQEFVKDKNIRHIIATARDVEKATDLKAISDPRVTALQLEVTCD 63
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPA-IDVSEEIIDNTFRVNVYGPINSCRE 121
+ K+E+ + L+LL NNAG + P + + VN + ++
Sbjct: 64 KSMDTFVSKVEEIVGSDGLNLLVNNAGNAVDYPCKAKPNRALFAEQLNVNTTSVVILTQK 123
Query: 122 FAPLIINAK-------------GTIVFTGSLAGICPFPFGA------VYSASKAAIHQYA 162
PL+I A + + LA + F G Y SKAAI+ +
Sbjct: 124 LMPLLIKASSKVSGDQLSASRAAVVTISSGLASMTDFATGGHAPNAFAYRISKAAINMFG 183
Query: 163 RVLHGELGPLGVRVINMITGGVATDIADKKTL 194
R L ++ + V ++ G V TD+ +K L
Sbjct: 184 RALANDMKDDHILVASIGPGWVKTDMGGEKAL 215
>At2g47130 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 58.5 bits (140), Expect = 1e-08
Identities = 57/191 (29%), Positives = 90/191 (46%), Gaps = 12/191 (6%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFG-DRCIPRKLDVSNQN 63
K A++TG +SGIG E + G V + + + G D+ + DV+N+
Sbjct: 9 KIAIITGGASGIGAEAVRLFTDHGAKVVIVDFQEELGQNVAVSVGKDKASFYRCDVTNEK 68
Query: 64 DITQ-LKLKLEQELPDQKLHLLYNNAG---QSCSLPAIDVSEEIIDNTFRVNVYGPINSC 119
++ +K +E+ KL +L++NAG Q S +D++ E D T VNV G
Sbjct: 69 EVENAVKFTVEKY---GKLDVLFSNAGVMEQPGSF--LDLNLEQFDRTMAVNVRGAAAFI 123
Query: 120 REFAPLIIN--AKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
+ A ++ +G+IV T S+A P Y+ASK A+ + G LG G+RV
Sbjct: 124 KHAARAMVEKGTRGSIVCTTSVASEIGGPGPHAYTASKHALLGLVKSACGGLGKYGIRVN 183
Query: 178 NMITGGVATDI 188
+ VAT I
Sbjct: 184 GVAPYAVATAI 194
>At1g07450 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 58.5 bits (140), Expect = 1e-08
Identities = 52/189 (27%), Positives = 84/189 (43%), Gaps = 6/189 (3%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---GDRCIPRKLDVSNQN 63
ALVTG S GIGY + +EL+ G V+ C + E + + G DVS++
Sbjct: 13 ALVTGGSKGIGYAIVEELVGFGARVHICDIDETLLNECLSGWHAKGFEVSGSICDVSSRP 72
Query: 64 DITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
QL ++ L KL++L NN G+ P ++ + E + N+ +
Sbjct: 73 QRVQL-MQTVSSLFGAKLNILINNVGKYILKPTLESTAEDFSSLMATNLESAYYISQLAH 131
Query: 124 PLI-INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITG 182
PL+ + G IVF S+ G+ +Y +K A++Q AR L E +R ++
Sbjct: 132 PLLKASGNGNIVFISSVTGVVS-GTSTIYGVTKGALNQLARDLACEWASDNIRANSVAPW 190
Query: 183 GVATDIADK 191
AT + K
Sbjct: 191 VTATSLVQK 199
>7295621 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 58.5 bits (140), Expect = 1e-08
Identities = 60/206 (29%), Positives = 99/206 (47%), Gaps = 19/206 (9%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF----GDRCIPRKLDVSNQ 62
A+VTGASSGIG +T++L+ G V A ARR +E+LR E R + DVS+
Sbjct: 9 AVVTGASSGIGAAITRKLISAGVMVVALARRMDRLEQLREELPQDRRSRLRIMQCDVSDV 68
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPIN-SCRE 121
+ + + ++ +L + + +L NNAG+ + +S + + + NV G + + R
Sbjct: 69 SSVNAVFDAVQGDLGN--VDILINNAGKLSGGQLLTMSVDTVQQMLQTNVMGVVYCTQRA 126
Query: 122 FAPL-IINAKGTIVFTGSLAG---ICPFPFGA----VYSASKAAIHQYARVLHGELGPL- 172
F + +KG +V S+ G P P +Y A+K AI + E+
Sbjct: 127 FESMRQRQSKGHVVLINSIVGHYIFNPLPGSQQELNMYPATKHAITALTELFRQEMRDFK 186
Query: 173 -GVRVINMITGGVATDIA--DKKTLP 195
V+V ++ G V T++ D K LP
Sbjct: 187 TKVKVTSISPGLVDTELVPLDYKGLP 212
>7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 399
Score = 58.2 bits (139), Expect = 1e-08
Identities = 51/174 (29%), Positives = 78/174 (44%), Gaps = 6/174 (3%)
Query: 4 TKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEE---LRAEFGDRCIPRKLDVS 60
T AL+TG +G+G + + L + G V + E + E G C +D+S
Sbjct: 86 TDIALITGGGNGLGRLLAERLGKMGTKVVIWDINKKGIAETVQIVEEAGGYCKGYVVDIS 145
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCR 120
+ ++ + + E+ D + LL NNAG L +D + +I+ +F VNV + +
Sbjct: 146 KKEEVYKAADVIRDEVGD--ITLLINNAGVVSGLHLLDTPDHLIERSFNVNVMAHFWTTK 203
Query: 121 EFAP-LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
F P +I N +G I SLAG Y ASK A + L EL LG
Sbjct: 204 AFLPKMIENDRGHIATIASLAGHVGISKLVDYCASKFAAVGFDEALRLELEVLG 257
>7296706_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 233
Score = 58.2 bits (139), Expect = 1e-08
Identities = 48/173 (27%), Positives = 72/173 (40%), Gaps = 4/173 (2%)
Query: 80 KLHLLYNNAG--QSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFAPLIINAKGTIVFTG 137
++ +L NNAG ++ S+ A S E D NV P ++ KG IV
Sbjct: 60 RIDVLVNNAGILETGSIEA--TSLEQFDRLMNTNVRSLYQLTMLATPELVKTKGNIVNVS 117
Query: 138 SLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGGVATDIADKKTLPEG 197
S+ G+ FP Y+ SKAA+ Q+ + EL P GVRV + G + TDI + + E
Sbjct: 118 SVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNPGVIVTDIHKRGGMDEE 177
Query: 198 SIFNFPEGIKAVETRKKMSEKNQPMSPADYARETVNDIENGSIDPVDIYRGTM 250
+ F E K + + + + + G PVD R M
Sbjct: 178 TYAKFLEHCKITHALGRPGDVKEVAAAIAFLASDQASFTTGISLPVDGGRHAM 230
>Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 179
Score = 57.8 bits (138), Expect = 2e-08
Identities = 46/180 (25%), Positives = 85/180 (46%), Gaps = 4/180 (2%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K V G S GIG V + + R+G+ + AR + + G + DV+ ++D
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 62
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFAP 124
+ ++E+ L +++ L N AG + + E + + N+ G + +C+
Sbjct: 63 VQNTFEEMEKHL--GRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMR 120
Query: 125 LIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGG 183
+I + G+IV GS+ G+ +VYSASK + ++R L E+ +RV N++ G
Sbjct: 121 TMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRV-NVVAPG 179
>CE21095 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 57.8 bits (138), Expect = 2e-08
Identities = 52/203 (25%), Positives = 89/203 (43%), Gaps = 13/203 (6%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRK------LD 58
K ++TG+S+GIG + G V R + +EE R + K D
Sbjct: 7 KTVIITGSSNGIGRTTAILFAQEGANVTITGRSSERLEETRQIILKSGVSEKQVNSVVAD 66
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSC----SLPAIDVSEEIIDNTFRVNVYG 114
V+ ++ Q+ ++ K+ +L NNAG + D +I T ++N+
Sbjct: 67 VTTEDGQDQIINSTLKQFG--KIDVLVNNAGAAIPDAFGTTGTDQGIDIYHKTLKLNLQA 124
Query: 115 PINSCREFAPLIINAKGTIVFTGSL-AGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
I ++ P ++ +KG IV S+ AG P Y+ +KAA+ QY R +L G
Sbjct: 125 VIEMTKKVKPHLVASKGEIVNVSSIVAGPQAQPDFLYYAIAKAALDQYTRSTAIDLAKFG 184
Query: 174 VRVINMITGGVATDIADKKTLPE 196
+RV ++ G V T + +P+
Sbjct: 185 IRVNSVSPGMVETGFTNAMGMPD 207
>At3g26760 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 57.8 bits (138), Expect = 2e-08
Identities = 52/190 (27%), Positives = 85/190 (44%), Gaps = 6/190 (3%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ 62
E K A++TG +SGIG +E + +G V + E G + DV+ +
Sbjct: 6 EGKVAVITGGASGIGKATAEEFVSQGAQVIIVDIDEEAGHMVATELGSAAHFLRCDVTEE 65
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSL--PAI-DVSEEIIDNTFRVNVYGPINSC 119
I K KL ++ N+AG SCS+ P+I D+ + D R+NV G +
Sbjct: 66 EQIA--KAVETAVTRHGKLDVMLNSAGISCSISPPSIADLDMDTYDKVMRLNVRGTVLGI 123
Query: 120 REFAPLIINA-KGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVIN 178
+ A +I A G+I+ S++G+ YS SK I + + EL G+R+
Sbjct: 124 KHAARAMIPAGSGSILCLSSISGLMGGLGPHAYSISKFTIPGVVKTVASELCKHGLRINC 183
Query: 179 MITGGVATDI 188
+ G+ T +
Sbjct: 184 ISPAGIPTPL 193
>Hs7657478 [Q] KOG1205 Predicted dehydrogenase
Length = 311
Score = 57.4 bits (137), Expect = 3e-08
Identities = 55/204 (26%), Positives = 90/204 (43%), Gaps = 14/204 (6%)
Query: 8 LVTGASSGIGYEVTKELL---RRGWYVYACARRTHPMEELRAEFGDRC----IPRKLDVS 60
L++G SSGIG E+ +L ++ + V A R E L A G+ +LDV
Sbjct: 9 LISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVC 68
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCR 120
+ + Q ++ E+ +L NNAG P +S + N F N +G + +
Sbjct: 69 SDESVAQCLSCIQGEVD-----VLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVK 123
Query: 121 EFAP-LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
P + +G IV S+ G+ F VY+ASK A+ + L +L + + +
Sbjct: 124 AVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLV 183
Query: 180 ITGGVATDIADKKTLPEGSIFNFP 203
G V T+ + K L + S+ FP
Sbjct: 184 EPGPVVTEF-EGKLLAQVSMAEFP 206
>7300387 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 57.4 bits (137), Expect = 3e-08
Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 25/215 (11%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF-----GDRCIPRKL 57
E K ++TGA+SGIG E K+L RG + R ++ E ++ + +KL
Sbjct: 32 EGKTVIITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKETKNNKILVKKL 91
Query: 58 DVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGP-- 115
D+ +Q + + + + P K+ +L +NAG + + SE+ ++ T N YGP
Sbjct: 92 DLGSQKSVREFAADIVKTEP--KIDVLIHNAGMALAFRG-QTSEDGVELTMATNHYGPFL 148
Query: 116 -----INSCREFAP---LIINAKGTIVFTGSLAGICP---FPFGAVYSASKAAIHQYARV 164
I+ ++ AP +I+ ++ + + +LA + P FP +Y SK A +AR
Sbjct: 149 LTHLLIDVLKKSAPARIVIVASELYRLSSVNLAKLNPIGTFPAAYLYYVSKFANIYFARE 208
Query: 165 LHGELGPLGVRV----INMITGGVATDIADKKTLP 195
L L V V MI G+ ++ LP
Sbjct: 209 LAKRLEGTKVTVNFLHPGMIDSGIWRNVPFPLNLP 243
>At3g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 259
Score = 57.0 bits (136), Expect = 3e-08
Identities = 53/189 (28%), Positives = 87/189 (45%), Gaps = 8/189 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFG-DRCIPRKLDVSNQN 63
K ++TG +SGIG E + G V + + + G D+ + D++++
Sbjct: 9 KIVIITGGASGIGAEAARLFTDHGAKVVIVDLQEELGQNVAVSIGLDKASFYRCDITDET 68
Query: 64 DITQ-LKLKLEQELPDQKLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYGPINSCRE 121
++ +K +E+ KL +L++NAG +I D+ E D T VNV G +
Sbjct: 69 EVENAVKFTVEKH---GKLDVLFSNAGVMEPHGSILDLDLEAFDRTMAVNVRGAAAFIKH 125
Query: 122 FAPLII--NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
A ++ +G+IV T S+ P Y+ASK A+ R G LG G+RV +
Sbjct: 126 AARSMVASGTRGSIVCTTSVTAEIGGPGPHSYTASKHALLGLVRSACGGLGKYGIRVNGV 185
Query: 180 ITGGVATDI 188
GVAT +
Sbjct: 186 APYGVATGL 194
>CE05801 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 374
Score = 56.6 bits (135), Expect = 4e-08
Identities = 56/211 (26%), Positives = 89/211 (41%), Gaps = 8/211 (3%)
Query: 8 LVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGD---RCIPRKLDVSNQND 64
L+TG +G G E+ K+ + G+ V+A T + L +E + R +P LDVS
Sbjct: 32 LITGCDTGFGRELAKKCAKNGFLVFAGCLTTEAAKTLESESANPRLRTVP--LDVSKDES 89
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAG-QSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFA 123
+ + +++ L + KL + NNAG SC P VN G I + F
Sbjct: 90 VEKTVEFVKKSLGNHKLWGVVNNAGIFSCYGPDDWCRMNDYKLALDVNCLGVIRVTQAFK 149
Query: 124 PLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGG 183
L+ AKG IV S+ G P Y SK Y + +G L + + +
Sbjct: 150 KLVKAAKGRIVTVTSVNGRLSTPAAGPYVVSKFGAAAYMDCIRFVIGVLDILIKFSVFSF 209
Query: 184 VATDIADKKTLPEGSIFNFPEGIKAVETRKK 214
V + D + LP + + G + V+ K+
Sbjct: 210 VFKN--DIQLLPISNFSSLMFGFRIVQEYKQ 238
>At5g18210 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 56.6 bits (135), Expect = 4e-08
Identities = 57/197 (28%), Positives = 90/197 (44%), Gaps = 15/197 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGW-YVYACARRTHPMEELRAEFGDRC--IPRKL---- 57
+ A+VTG+S GIG + L G V R+ +++ AE +P+ +
Sbjct: 11 RVAIVTGSSRGIGRAIAIHLAELGAKIVINYTTRSTEADQVAAEINSSAGTVPQPIAVVF 70
Query: 58 --DVSNQNDITQLKLKLEQELPDQKLHLLYNNAG-QSCSLPAI-DVSEEIIDNTFRVNVY 113
D+S + I L E+ + +H+L N+AG + + P I + E D F+VN
Sbjct: 71 LADISEPSQIKSLFDAAEKAF-NSPVHILVNSAGILNPNYPTIANTPIEEFDRIFKVNTR 129
Query: 114 GPINSCREFAPLIINAKG--TIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGP 171
G C+E A + G I+ T SL P Y+ASKAA+ ++L EL
Sbjct: 130 GSFLCCKEAAKRLKRGGGGRIILLTSSLTEAL-IPGQGAYTASKAAVEAMVKILAKELKG 188
Query: 172 LGVRVINMITGGVATDI 188
LG+ + G VAT++
Sbjct: 189 LGITANCVSPGPVATEM 205
>7297069 [Q] KOG1205 Predicted dehydrogenase
Length = 246
Score = 56.6 bits (135), Expect = 4e-08
Identities = 62/205 (30%), Positives = 91/205 (44%), Gaps = 25/205 (12%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELR----AEFGDRCIPRKLD 58
+ K A+VTGAS GIG + ++ G V ARR ++ELR E IPR+ D
Sbjct: 5 QNKLAVVTGASGGIGAACARAMIGAGLRVVGLARREAKLKELRESLPRELQANFIPRRCD 64
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVS-----EEIIDNTFRVNVY 113
VS ++ + +E+EL + +L NNAG + + S +E+ID NV
Sbjct: 65 VSKEDQVQSSFDWIEREL--EGADVLLNNAGITRETELVTPSNTQKLKEVID----TNVM 118
Query: 114 GPINSCREFAPLI--INAKGTIVFTGSLAG------ICPFPFGAVYSASKAAIHQYARVL 165
G I RE + +G ++ S+AG I P +Y A+K AI
Sbjct: 119 GVIWCTREAFNNMKRRGGEGHVLIINSIAGHQVLNFIDVLPSFNIYPATKFAITAITETY 178
Query: 166 HGE--LGPLGVRVINMITGGVATDI 188
E L +RV + G V T+I
Sbjct: 179 RQEFQLHSNKIRVTGICPGAVNTNI 203
>At1g01800 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 309
Score = 56.2 bits (134), Expect = 6e-08
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 13/134 (9%)
Query: 4 TKYALVTGASSGIGYEVTKELLRRGWYVYACARRTH----PMEELRAE--FGDRCIP-RK 56
++ A+VTG++ GIG+E+ ++L G V AR + +++L+ E F D+ I
Sbjct: 34 SRVAVVTGSNKGIGFEICRQLANNGITVVLTARDENKGLAAVQKLKTENGFSDQAISFHP 93
Query: 57 LDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSE----EIIDNTFRVNV 112
LDVSN + I L ++ KL +L NNAG + +DV + EI++ + N
Sbjct: 94 LDVSNPDTIASLAAFVKTRF--GKLDILVNNAGVGGANVNVDVLKAQIAEIVEECVKTNY 151
Query: 113 YGPINSCREFAPLI 126
YG C PL+
Sbjct: 152 YGVKRMCEAMIPLL 165
>Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 55.8 bits (133), Expect = 7e-08
Identities = 49/170 (28%), Positives = 76/170 (43%), Gaps = 6/170 (3%)
Query: 8 LVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAE---FGDRCIPRKLDVSNQND 64
L+TGA GIG + T E +R + +EE AE G +D SN+ +
Sbjct: 40 LITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREE 99
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFAP 124
I + ++++E+ D + ++ NNAG + +E I TF VN+ G + P
Sbjct: 100 IYRSLNQVKKEVGD--VTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLP 157
Query: 125 LIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLG 173
++ G IV S+ G P+ Y +SK A + R L EL LG
Sbjct: 158 SMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALG 207
>At3g03980 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 55.5 bits (132), Expect = 1e-07
Identities = 70/257 (27%), Positives = 104/257 (40%), Gaps = 24/257 (9%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVY-------ACARRT------HPMEELRAEFGDR 51
+ A+VTG+S GIG + L G + A A R P+ E G R
Sbjct: 17 RVAIVTGSSRGIGRAIAIHLAELGARIVINYTSKAADAERVASEINDFPVREEITGKGPR 76
Query: 52 CIPRKLDVSNQNDITQLKLKLEQELPDQKLHLLYNNAG-QSCSLPAI-DVSEEIIDNTFR 109
I + +VS + + + E + +H+L N+AG P I D S E D+TF
Sbjct: 77 AIVVQANVSEPSQVKSMFDAAESAF-EAPVHILVNSAGILDPKYPTIADTSVEDFDHTFS 135
Query: 110 VNVYGPINSCREFAPLIINAKG--TIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHG 167
VN G +E A + G I+ T S FGA Y+ASKAA+ ++L
Sbjct: 136 VNTKGAFLCSKEAANRLKQGGGGRIILLTSSQTRSLKPGFGA-YAASKAAVETMVKILAK 194
Query: 168 ELGPLGVRVINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADY 227
EL G+ + G +AT++ PE E I A ++ E + +
Sbjct: 195 ELKGTGITANCVAPGPIATEMFFDGKTPE-----LVEKIAAESPFGRVGEAKDVVPLVGF 249
Query: 228 ARETVNDIENGSIDPVD 244
+ NG I PV+
Sbjct: 250 LAGDGGEWVNGQIIPVN 266
>7304176 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 280
Score = 55.5 bits (132), Expect = 1e-07
Identities = 54/190 (28%), Positives = 85/190 (44%), Gaps = 17/190 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF-----GDRCIPRKLDV 59
K +VTGA++GIG E E+ RRG VY R + E+ R + R+LD+
Sbjct: 15 KVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARKDIIKETNNQNIFSRELDL 74
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSC 119
S+ + I + ++E P KLH+L NNAG + + + + + + + +N
Sbjct: 75 SSLDSIRKFVDGFKKEQP--KLHVLINNAG------VMRCPKTLTKDGYELQL--GVNHI 124
Query: 120 REFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
F L+ N ++ L + G YS SK A + R L L GV V +
Sbjct: 125 GHF--LLTNLLLDVLKATDLNSEKSYDEGLAYSQSKLANVLFTRELAKRLEGSGVTVNAL 182
Query: 180 ITGGVATDIA 189
G V T++A
Sbjct: 183 HPGVVDTELA 192
>CE03132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 55.1 bits (131), Expect = 1e-07
Identities = 56/194 (28%), Positives = 83/194 (41%), Gaps = 15/194 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
K A++TG+SSGIG E + G V R +EE + D I + D
Sbjct: 8 KVAIITGSSSGIGRETALLFAKEGAKVTVTGRSEEKLEETKKALLDAGIKESNFLIVPAD 67
Query: 65 IT----QLKLKLEQELPDQKLHLLYNNAGQSC----SLPAIDVSEEIIDNTFRVNVYGPI 116
IT Q +L + ++++L NNAG S ID E + ++NV I
Sbjct: 68 ITFSTGQDELISQTLKKFGRINILVNNAGASIPDAKKRTGIDQGIETYEQVMKLNVQSVI 127
Query: 117 NSCREFAPLIINAKGTIVFTGSL----AGICPFPFGAVYSASKAAIHQYARVLHGELGPL 172
++ P + ++G IV S+ AG P+ Y +KAA+ QY R L
Sbjct: 128 EMTQKVRPHLAKSRGEIVNVSSVVALKAGWTRTPY---YPLAKAALDQYTRSAAIALISE 184
Query: 173 GVRVINMITGGVAT 186
G+RV + G V T
Sbjct: 185 GIRVNTVNPGIVQT 198
>At4g05530 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 254
Score = 55.1 bits (131), Expect = 1e-07
Identities = 51/191 (26%), Positives = 86/191 (44%), Gaps = 8/191 (4%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPR---KLDV 59
E K A+VT ++ GIG+ +T+ G V +R+ ++E A+ + I V
Sbjct: 10 EGKVAIVTASTQGIGFGITERFGLEGASVVVSSRKQANVDEAVAKLKSKGIDAYGIVCHV 69
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSL-PAIDVSEEIIDNTFRVNVYGPINS 118
SN L K Q+ K+ ++ NA + S P + E ++D + +NV I
Sbjct: 70 SNAQHRRNLVEKTVQKY--GKIDIVVCNAAANPSTDPILSSKEAVLDKLWEINVKSSILL 127
Query: 119 CREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVIN 178
++ AP + +++F S+AG P A+Y +K A+ + L E+ P RV
Sbjct: 128 LQDMAP-HLEKGSSVIFITSIAGFSPQGAMAMYGVTKTALLGLTKALAAEMAP-DTRVNA 185
Query: 179 MITGGVATDIA 189
+ G V T A
Sbjct: 186 VAPGFVPTHFA 196
>7292613 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 55.1 bits (131), Expect = 1e-07
Identities = 57/208 (27%), Positives = 94/208 (44%), Gaps = 20/208 (9%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELR----AEFGDRCIPRKLD 58
+ + A+VTGASSGIG + K+L+ G V ARR ++EL+ AE + D
Sbjct: 5 QNRVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRVKELQRELPAEKRGKLFALYCD 64
Query: 59 VSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINS 118
V N++ + + + Q+L + +L NNAG +D++ ++ + N+ G I
Sbjct: 65 VGNESSVNEAFDWIIQKL--GAIDVLVNNAGTLQPGYLVDMNPAVMQQVLQTNIMG-IVL 121
Query: 119 CREFAPLIINAK---GTIVFTGSLAGICPF-------PFGAVYSASKAAIHQYARVLHGE 168
C + A + + G +V S+ G P VY SK A+ A E
Sbjct: 122 CTQRAVRSMRERKFDGHVVLINSILGHKTMTATEGVAPDVNVYPPSKHAVTALAEGYRQE 181
Query: 169 LGPLGVRVINMITGGVATDIADKKTLPE 196
LG R+ IT V+ + D + +P+
Sbjct: 182 FFGLGTRI--KIT-SVSPGVVDTEIVPD 206
>YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 308
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/199 (25%), Positives = 93/199 (46%), Gaps = 18/199 (9%)
Query: 1 MSETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHP---MEELRAEFGDRCIPRKL 57
+S+ AL+TG SSG+G+E+ KEL RR V ++ P E F +C
Sbjct: 35 LSKNATALITGGSSGLGFELAKELSRRINKVIVADIQSFPTFAQVEYNNIFYYQC----- 89
Query: 58 DVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPIN 117
D+++ ++I LK +E++ ++++ NNAG + ++ + ++ +N+ G
Sbjct: 90 DITSLDEIKNLKKAIERD--HGNINIIINNAGVAHIKKLEHMTNKEVEQLIDINLIGAYR 147
Query: 118 SCREFA-PLIINAKGTIVFTGSLAGICPFPFGAVYSASKAA-------IHQYARVLHGEL 169
FA +I N +G I+ S+ G Y ASK A + ++ R L E
Sbjct: 148 IISTFAEDMIDNREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLSTEC 207
Query: 170 GPLGVRVINMITGGVATDI 188
G++ + + G + T++
Sbjct: 208 NKTGIKTLLVCPGKIKTNM 226
>SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/193 (28%), Positives = 91/193 (46%), Gaps = 12/193 (6%)
Query: 5 KYALVTGASSGIGYEVTKELL-RRGWYVYACARRTHPMEELR--AEFGDRCIPRKLDVSN 61
K + G + GIG + KEL R G V+A AR+ EL+ ++ +LDV++
Sbjct: 6 KVYFIAGGNRGIGLSLVKELSSREGTTVFASARKPEAATELQEWSKSHPNVKTVELDVTS 65
Query: 62 QNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYGPINSCR 120
Q + + + + + +L+ N+G S + + EE+ + ++ NV GPI+ +
Sbjct: 66 QQSANEAAQSVAKAVDG--IDVLWLNSGICQSYYTVMEAPEEVWNAHYQTNVLGPIHVFK 123
Query: 121 EFAPLIINAK-GTIVFT----GSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
F PL+ K ++FT GS+ F A Y SKAAI+ + L EL
Sbjct: 124 AFYPLLTKKKTRQVIFTSSECGSMGDFRATGFSA-YGQSKAAINFTMKELSVELADEHFT 182
Query: 176 VINMITGGVATDI 188
I++ G V TD+
Sbjct: 183 FISIHPGVVKTDM 195
>CE09969 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 54.7 bits (130), Expect = 2e-07
Identities = 53/192 (27%), Positives = 88/192 (45%), Gaps = 11/192 (5%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEE----LRAEFGDRCIPRKLDVS 60
+ ALVT ++ GIG+ + K+L G V C+R+ ++E LR E D V
Sbjct: 12 RVALVTASTKGIGFAIAKQLGAAGASVVVCSRKKENVDEAVAALRLENID-AHGTTAHVG 70
Query: 61 NQNDITQL-KLKLEQELPDQKLHLLYNNAGQSCSL-PAIDVSEEIIDNTFRVNVYGPINS 118
N++D T+L L++ KL +L +NA + + V++ D +NV
Sbjct: 71 NKSDRTKLIDFTLDR---FTKLDILVSNAAVNPHYGDLMKVTDSQWDKLLDLNVKSAFEL 127
Query: 119 CREFAP-LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
+E P L + +G +VF S+AG P YS K + ++ L L +RV
Sbjct: 128 TKEAVPHLEASGRGNVVFVSSVAGYSPMNEIGAYSVMKTTLTGLSKSLALNLARRNIRVN 187
Query: 178 NMITGGVATDIA 189
++ G + TD +
Sbjct: 188 SIAPGIIQTDFS 199
>7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 278
Score = 54.7 bits (130), Expect = 2e-07
Identities = 66/257 (25%), Positives = 109/257 (41%), Gaps = 33/257 (12%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEE---LRAEFGDRCIP-RKLDVS 60
K A+VTG + GIG +V+K+LL G A +EE LRA + + K+DV+
Sbjct: 23 KNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVMIIKMDVA 82
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCR 120
N+ + ++ + + + ++ N AG +++ + T VN+ G INS
Sbjct: 83 NKKGVEATYEEIAKTFGN--IDIVVNVAG--------IFNDKDVQRTLLVNLGGIINSTL 132
Query: 121 EFAPLIINAK----GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGE--LGPLGV 174
P + G +V S+ G+ P VY A+KA I + R L E G+
Sbjct: 133 SALPYMGKDNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGI 192
Query: 175 RVINMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRK---KMSEKNQPMSPADYARET 231
+ + + G TD+ NF E I ET ++ ++ S AD +R
Sbjct: 193 KFVTVCPGATMTDM----------FTNFTEKIIFPETSDETYRILDRLNKQSAADVSRCI 242
Query: 232 VNDIENGSIDPVDIYRG 248
+N +E V + G
Sbjct: 243 LNVLEKDKNGAVYVIEG 259
>7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 255
Score = 54.7 bits (130), Expect = 2e-07
Identities = 47/195 (24%), Positives = 84/195 (42%), Gaps = 15/195 (7%)
Query: 1 MSETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVS 60
M + +LVTG +SG+G + L ++G V + E+ E GD+ + +DV+
Sbjct: 1 MIKNAVSLVTGGASGLGRATAERLAKQGASVILADLPSSKGNEVAKELGDKVVFVPVDVT 60
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEI------IDNTFRVNVYG 114
++ D++ + + +L L N AG + ++ + ++ + +N G
Sbjct: 61 SEKDVSAALQTAKDKF--GRLDLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVG 118
Query: 115 PINSCREFAPLI-------INAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHG 167
N R A L+ +G IV T S+A A YSASKAA+ +
Sbjct: 119 TFNVIRLSAGLMGANEPNQDGQRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIAR 178
Query: 168 ELGPLGVRVINMITG 182
+L G+R+ + G
Sbjct: 179 DLSTQGIRICTIAPG 193
>CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 315
Score = 54.3 bits (129), Expect = 2e-07
Identities = 52/194 (26%), Positives = 88/194 (44%), Gaps = 12/194 (6%)
Query: 6 YALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKL-----DVS 60
+A+VTGA+ GIG + EL RRG+ VY +R +E+ + + ++ ++ D +
Sbjct: 49 WAVVTGATDGIGKSYSFELARRGFNVYIVSRTQSKLEQTKKDILEKQPDIEVRFATYDFT 108
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLP----AIDVSEEIIDNTFRVNVYGPI 116
N + +T + KL +L + + +L NN G P I+ + I N +N
Sbjct: 109 NPS-VTDYE-KLLSKLNEVSVGILINNVGMFFDYPEMLHKINGGIDSIANVIIINTLPAT 166
Query: 117 NSCREFAPLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
P +++ K G IV GS AG+ ++YSA+K + L E G+
Sbjct: 167 LLSAGILPQMVSRKAGIIVNIGSFAGVVKLAEWSIYSATKKYVEWLTGCLRKEYSHHGII 226
Query: 176 VINMITGGVATDIA 189
+ VAT +A
Sbjct: 227 FQAITPAMVATKMA 240
>7300831 [Q] KOG1205 Predicted dehydrogenase
Length = 248
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/193 (27%), Positives = 85/193 (43%), Gaps = 12/193 (6%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFG--DRCIPRKLDVSNQ 62
K A+VTGAS GIG EL G V ARR +E LR + + R+ D++++
Sbjct: 10 KVAVVTGASVGIGATTAIELANAGMVVVGLARRVELIEALRDQVTGVGKIFARQCDLNDE 69
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREF 122
+ + ++ Q +H+L NAG + + + I F NV + RE
Sbjct: 70 EQLASAFNWIREKF--QAIHVLICNAGILKANFLSESPTKDIKELFDTNVVATASCLREA 127
Query: 123 AP--LIINAKGTIVFTGSLAG----ICPFPFGAVYSASKAAIHQYARVLHGELG--PLGV 174
+ +G IV S+ G P P +VY A+K AI + + E+ L +
Sbjct: 128 LKHMAAVKVRGHIVVMNSVLGHRIPEVPVPLFSVYPATKHAITALCQTVRQEIHFLKLNI 187
Query: 175 RVINMITGGVATD 187
++ ++ G V TD
Sbjct: 188 KLTSICPGMVDTD 200
>YIR035c [Q] KOG1204 Predicted dehydrogenase
Length = 254
Score = 53.9 bits (128), Expect = 3e-07
Identities = 64/241 (26%), Positives = 102/241 (41%), Gaps = 14/241 (5%)
Query: 5 KYALVTGASSGIGYEVTKEL--LRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ 62
K LVTG S GIG + L L + VY AR P+++L+ ++GDR D++
Sbjct: 3 KVILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEAPLKKLKEKYGDRFFYVVGDITED 62
Query: 63 NDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFR----VNVYGPINS 118
+ + QL + K+ L NAG L + EI N ++ +N + ++
Sbjct: 63 SVLKQLVNAAVKG--HGKIDSLVANAGV---LEPVQNVNEIDVNAWKKLYDINFFSIVSL 117
Query: 119 CREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVIN 178
P + G +VF S A F Y +SKAA++ +A L E V+ I
Sbjct: 118 VGIALPELKKTNGNVVFVSSDACNMYFSSWGAYGSSKAALNHFAMTLANE--ERQVKAIA 175
Query: 179 MITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPAD-YARETVNDIEN 237
+ G V TD+ G E +K K+ ++ PA YA+ ++ I +
Sbjct: 176 VAPGIVDTDMQVNIRENVGPSSMSAEQLKMFRGLKENNQLLDSSVPATVYAKLALHGIPD 235
Query: 238 G 238
G
Sbjct: 236 G 236
>CE14538 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 53.9 bits (128), Expect = 3e-07
Identities = 59/193 (30%), Positives = 85/193 (43%), Gaps = 17/193 (8%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQNDIT 66
A+VTG+S+GIG L G V R +EE R +P S D+T
Sbjct: 10 AIVTGSSNGIGRATAILLASEGAKVTITGRNAERLEESRQALLKVGVPSGHINSVVADVT 69
Query: 67 Q---LKLKLEQELPD-QKLHLLYNNAGQSCSLPA----IDVSEEIIDNTFRVNVYGPINS 118
+ ++ L K+++L NNAG P E TF++N +
Sbjct: 70 TGAGQDVLIDSTLKKFGKINILINNAGALIVDPEGKTNTSTGVETCLKTFQLNFQSVVEM 129
Query: 119 CREFAPLIINAKGTIVFTGSLAGICP-----FPFGAVYSASKAAIHQYARVLHGELGPLG 173
++ P + N G IV S+ G P FP+ YSA+KAA+ QY+R +L P G
Sbjct: 130 TQKIRPHLANTHGEIVNVSSV-GAGPAAENRFPY---YSAAKAALDQYSRNTAIDLIPDG 185
Query: 174 VRVINMITGGVAT 186
+RV + G VAT
Sbjct: 186 IRVNIVQPGFVAT 198
>CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 53.9 bits (128), Expect = 3e-07
Identities = 54/194 (27%), Positives = 85/194 (42%), Gaps = 12/194 (6%)
Query: 6 YALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQN-D 64
+A+VTGA+ GIG + EL +RG+ VY +R +E + E + + ++V D
Sbjct: 49 WAVVTGATDGIGKSYSFELAKRGFNVYIVSRTQSKLEHTKKEILE--VHPDIEVRFATFD 106
Query: 65 ITQLKL----KLEQELPDQKLHLLYNNAGQSCSLP----AIDVSEEIIDNTFRVNVYGPI 116
T + KL +L + + +L NN G P I+ + I N +N
Sbjct: 107 FTNPSVSDYEKLLSKLNEVSIGILINNVGMFFDYPEMLHKINGGIDSIANVTIINTLPAT 166
Query: 117 NSCREFAPLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
P ++ K G IV GS+AG+ +VYSA+K + L E G G+
Sbjct: 167 LLSAGILPQMVPRKAGIIVNIGSVAGLATMAEWSVYSATKKYVEWITGCLQKEYGHQGII 226
Query: 176 VINMITGGVATDIA 189
+ VAT +A
Sbjct: 227 FQAITPAMVATKMA 240
>7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 325
Score = 53.9 bits (128), Expect = 3e-07
Identities = 48/179 (26%), Positives = 84/179 (46%), Gaps = 11/179 (6%)
Query: 8 LVTGASSGIGYEVTKELLRRG-----WYVYACARRTHPMEELRAEFG-DRCIPRKLDVSN 61
L+TG G+G + R W + A +T +L A+ G D C +D+S+
Sbjct: 60 LITGGGGGVGRLIALNFARLQARIVIWDINQEAIKT--TVDLLAKHGYDNCKGYVVDISD 117
Query: 62 QNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCRE 121
+ I Q ++ +E+ + +L NNAG C P ++ + +I NT+ +N+ + +
Sbjct: 118 REQIYQRASQVTEEVGP--VDILINNAGIVCCKPFWELHDRVIQNTYNINIISHYWTVKA 175
Query: 122 FAP-LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
F P ++ N +G IV GS+ G+ + Y+A+K A + L +L G I M
Sbjct: 176 FLPHMMRNNRGHIVTVGSVTGMLGTYGCSDYAATKYACIGFHESLLTDLKAHGYDQIQM 234
>SPCC162.03 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 53.5 bits (127), Expect = 4e-07
Identities = 48/185 (25%), Positives = 88/185 (46%), Gaps = 9/185 (4%)
Query: 8 LVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQNDITQ 67
L+TG+S G+GY + K L +G+ V AC+R + + E + + KLDV++ +
Sbjct: 9 LITGSSKGLGYALVKVGLAQGYNVIACSRAP---DTITIEH-SKLLKLKLDVTDVKSVET 64
Query: 68 LKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCREFAPLII 127
++ + + ++ NNAG + E + VN +G +E L+
Sbjct: 65 AFKDAKRRFGN--VDIVINNAGYGLVGEFESYNIEEMHRQMNVNFWGVAYITKEALNLMR 122
Query: 128 NA--KGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGP-LGVRVINMITGGV 184
+ G I+ S+AG P P ++Y+ASK A+ ++ + EL P + + + GG+
Sbjct: 123 ESGKGGRILQISSVAGYYPSPCLSMYNASKFAVEGLSQTIMRELDPNWNIAITIVQPGGM 182
Query: 185 ATDIA 189
T+ A
Sbjct: 183 QTEWA 187
>At5g15940 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 346
Score = 53.1 bits (126), Expect = 5e-07
Identities = 61/224 (27%), Positives = 91/224 (40%), Gaps = 41/224 (18%)
Query: 2 SETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKL---- 57
S ++TGA+SG+G L +G+YV R + + E E ++ +L
Sbjct: 39 SSRPICVITGATSGLGKATAFALAEKGFYVVLVGRSSQLLSETLKEIKNKNKDAQLKSFE 98
Query: 58 -DVSNQNDITQLKLKLEQELPDQKLH----LLYNNAG--QSCSLPAIDVSEEIIDNTFRV 110
D+S+ I K LEQ L D LH +L NNAG + S P ID + +I
Sbjct: 99 ADMSSFESIFTFKNSLEQWLSDSALHPSIQVLVNNAGILATSSRPTIDGYDRMI----AT 154
Query: 111 NVYGPINSCREFAPLIINAK------GTIVFT-----------GSLAGIC-----PFPFG 148
N GP + PL+ N+ FT S+ G+C +P
Sbjct: 155 NYVGPFFLTKLLLPLLKNSNVPSRVVNVTSFTHHSAFIQKLDKDSVTGVCFSTSNQYPCA 214
Query: 149 AVYSASKAAIHQYARVLHGELGPLG----VRVINMITGGVATDI 188
+Y SK + ++ LH +L + V VI G V T+I
Sbjct: 215 RIYEYSKLCLLLFSYELHRQLRLIDDSSHVSVIAADPGFVKTNI 258
>CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 349
Score = 52.8 bits (125), Expect = 6e-07
Identities = 53/198 (26%), Positives = 88/198 (43%), Gaps = 20/198 (10%)
Query: 6 YALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKL-----DVS 60
+A++TG + GIG + EL +RG+ +Y +R +E+ + E ++ ++ D +
Sbjct: 49 WAVITGGTDGIGKSFSFELAKRGFNIYIVSRTQSKLEQTKKEIMEKYSNVEVRFATFDFT 108
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLP--------AIDVSEEI-IDNTFRVN 111
N + I+ K KL +L + + +L NN G P IDV + I NT V
Sbjct: 109 NPS-ISDYK-KLLSQLNEVSIGMLINNVGMLFEYPENLHKTVGGIDVVANVTILNTLPVT 166
Query: 112 VYGPINSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGP 171
+ S ++ G IV GS+AG +VYSASK + L E
Sbjct: 167 LL----SAGILPQMVSRKTGIIVNIGSVAGAAKMAEWSVYSASKKYVEWLTGCLRKEYEH 222
Query: 172 LGVRVINMITGGVATDIA 189
G+ + + VAT ++
Sbjct: 223 QGIIIQAITPALVATKLS 240
>CE03954 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 274
Score = 52.8 bits (125), Expect = 6e-07
Identities = 54/195 (27%), Positives = 87/195 (43%), Gaps = 17/195 (8%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQN- 63
K A++TG+S+GIG L G V R +EE R + + +N N
Sbjct: 7 KVAIITGSSNGIGRATAVLLATDGAKVTITGRDAARLEETRQAI----LKAGISATNVNS 62
Query: 64 ---DITQLK---LKLEQELPD-QKLHLLYNNAG----QSCSLPAIDVSEEIIDNTFRVNV 112
D+T + L + L K+++L NNAG S S E + F++N+
Sbjct: 63 VVADVTTAEGQDLLISSTLDKFGKINILINNAGANIPDSQGQTRTKCSIENLTKMFQLNL 122
Query: 113 YGPINSCREFAPLIINAKGTIVFTGSL-AGICPFPFGAVYSASKAAIHQYARVLHGELGP 171
+ ++ P + +G IV S+ AG P YS++KAA+ QY+R +L
Sbjct: 123 QSVVEMVQKVRPHLAKTRGEIVNISSIGAGPAAQPASPYYSSAKAALDQYSRCAAIDLIS 182
Query: 172 LGVRVINMITGGVAT 186
G+R+ + G V+T
Sbjct: 183 EGIRINVVQPGFVST 197
>CE03613 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 262
Score = 52.8 bits (125), Expect = 6e-07
Identities = 62/257 (24%), Positives = 109/257 (42%), Gaps = 36/257 (14%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWY--VYACARRTHPMEELR--AEFGDRCIPRKLDVS 60
K +TGA+ GIG + ++LL+ + A AR ELR A+ +R +DV+
Sbjct: 4 KTVFITGANRGIGLGIVRKLLKVSEIEVIIAGARNLEAANELRELAKADNRLHAITVDVA 63
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAG-----QSCSLPAIDVSEEIIDNTFRVNVYGP 115
N + ++E + D+ L+LL NNAG ++ P+ S + D VN G
Sbjct: 64 NDERLANSVKQVESLVGDRGLNLLINNAGCYELYETTDSPSRKASLKCFD----VNAVGS 119
Query: 116 INSCREFAPLIINAKGTIVFTG---------SLAGICPFPF----------GAVYSASKA 156
+ + + F PL+ A TG ++ C F Y SK
Sbjct: 120 LMASQLFLPLLKKAAAHTHITGLSASRAAILNIGSDCSSQFLNGTPTVNDVSIAYKMSKV 179
Query: 157 AIHQYARVLHGELGPLGVRVI--NMITGGVATDI--ADKKTLPEGSIFNFPEGIKAVETR 212
A+ +AR L + L + V+ + G V T++ +D + E S + + I+ + T
Sbjct: 180 AMLSFARSLASDFRTLNIPVLIATIHPGWVLTEMGGSDAEITVEESATDIVDSIERLNTS 239
Query: 213 KKMSEKNQPMSPADYAR 229
+ + K Q + + ++
Sbjct: 240 HQGAAKLQNQAQVELSK 256
>At2g24190 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 52.8 bits (125), Expect = 6e-07
Identities = 44/147 (29%), Positives = 68/147 (45%), Gaps = 27/147 (18%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACAR----RTHPMEELR--AEFGDRCIP-RKL 57
+YA+VTG + GIG+E+ ++L +G V +R +E L+ E D+ I +L
Sbjct: 7 RYAIVTGGNRGIGFEICRQLANKGIRVILTSRDEKQGLEAVETLKKELEISDQSIVFHQL 66
Query: 58 DVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVS-----------EEIIDN 106
DVS+ +T L ++ KL +L NNAG + +D EE I
Sbjct: 67 DVSDPVSVTSLAEFVKTHF--GKLDILINNAGVGGVITDVDALRAGTGKEGFKWEETITE 124
Query: 107 TF-------RVNVYGPINSCREFAPLI 126
T+ ++N YGP C F PL+
Sbjct: 125 TYELAEECIKINYYGPKRMCEAFIPLL 151
>Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 323
Score = 52.4 bits (124), Expect = 8e-07
Identities = 49/191 (25%), Positives = 84/191 (43%), Gaps = 6/191 (3%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
KY +TG SG G + ++G++V A L+AE +R LDV++ +
Sbjct: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPEN 89
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAID-VSEEIIDNTFRVNVYGPINSCREFA 123
+ + ++ ++ ++ L L NNAG L D ++ E VN++G I+
Sbjct: 90 VKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNML 149
Query: 124 PLIINAK----GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
P + GT + + AG P G Y+ SK A+ + L ++ GV V +
Sbjct: 150 PRPQEDQPGQGGTTLPSPCTAGKLP-SVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCI 208
Query: 180 ITGGVATDIAD 190
G T++AD
Sbjct: 209 EPGLFKTNLAD 219
>Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 332
Score = 52.4 bits (124), Expect = 8e-07
Identities = 63/245 (25%), Positives = 96/245 (38%), Gaps = 23/245 (9%)
Query: 6 YALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAE-----FGDRCIPRKLDVS 60
+ +VTG SSGIG + E ++G ++ AR + + + E D+ + + V
Sbjct: 34 HVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVD 93
Query: 61 NQNDITQLKLKLEQELPDQKL---HLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPIN 117
D Q++ ++Q +KL +L N AG + S D+ + +N G +
Sbjct: 94 VSQDYNQVENVIKQ--AQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVY 151
Query: 118 SCREFAPLIINAK-GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRV 176
R + + G IVF S AG YSASK AI A L E+ P V
Sbjct: 152 PSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNV-- 209
Query: 177 INMITGGVATDIADKKTLPEGSIFNFPEGIKAVETRKKMSEKNQPMSPADYARETVNDIE 236
IT D E K +ETR +SE P A++ V D
Sbjct: 210 --YITVAYPPDTDTPGFAEENR-------TKPLETR-LISETTSVCKPEQVAKQIVKDAI 259
Query: 237 NGSID 241
G+ +
Sbjct: 260 QGNFN 264
>At3g51680 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 52.0 bits (123), Expect = 1e-06
Identities = 58/207 (28%), Positives = 84/207 (40%), Gaps = 33/207 (15%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYAC---------------ARRTHPMEELRAE 47
E K A++TG + GIG R G V + +T PM
Sbjct: 33 EGKVAIITGGAHGIGKATVMLFARHGATVVIADVDNVAGSSLAKSLSSHKTSPM----VA 88
Query: 48 FGDRCIPRKLDVSNQNDITQLKLKLEQELPDQKLHLLYNNAG----QSCSLPAIDVSEEI 103
F + + DV N ++T + +L +L+NNAG Q +D +
Sbjct: 89 FISCDVSVEADVENLVNVTVARYG--------RLDILFNNAGVLGDQKKHKSILDFDADE 140
Query: 104 IDNTFRVNVYGPINSCREFAPLIINA--KGTIVFTGSLAGICPFPFGAVYSASKAAIHQY 161
D+ RVNV G + A +I KG I+ T S+AG+ Y+ASK AI
Sbjct: 141 FDHVMRVNVRGVGLGMKHGARAMIKRGFKGCIISTASVAGVMGGMGPHAYTASKHAIVGL 200
Query: 162 ARVLHGELGPLGVRVINMITGGVATDI 188
+ ELG G+RV + GVAT +
Sbjct: 201 TKNAACELGKYGIRVNCISPFGVATSM 227
>7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 335
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/135 (29%), Positives = 58/135 (42%), Gaps = 3/135 (2%)
Query: 56 KLDVSNQNDITQLKLKLEQEL---PDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNV 112
+LD+ + I + +L L P +L L NNAG C E I+ N+
Sbjct: 86 ELDLLEPDSIRLVHRQLRDILAKDPSYRLTALINNAGVMCFGEFEWQLTEQIEAQINCNL 145
Query: 113 YGPINSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPL 172
G + E PL+ +G I+ S G+ P Y+ASKAA+ + L EL
Sbjct: 146 LGTMRLTHELLPLLRQQQGRIINVTSHCGLQALPALGPYAASKAALRFWTDSLRVELQQY 205
Query: 173 GVRVINMITGGVATD 187
G+ V+N I G D
Sbjct: 206 GMEVVNFIPGSFVLD 220
>SPAC8E11.10 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 255
Score = 51.2 bits (121), Expect = 2e-06
Identities = 54/192 (28%), Positives = 89/192 (46%), Gaps = 10/192 (5%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYV-YACARRTHPME---ELRAEFGDRCIPRKLDVS 60
K L+TG S GIG+ + K G V R +E ELR + G + +
Sbjct: 10 KTTLITGGSGGIGFSIAKAFAAAGSNVGLLYGRNKKALEYAAELRDKHGVQAKAYSCPIE 69
Query: 61 NQNDITQLKLKLEQELPDQKLHLLYNNAGQSC-SLPAIDVSEEIIDNTFRVNVYGPINSC 119
N++ + + + +EL +L ++ NAG + L D +E+I +N+ G +
Sbjct: 70 NRSAVIETTNQAVEEL-GGRLDVMIANAGIAIPHLSLEDKNEDIWTKVVGINLNGAYYTA 128
Query: 120 REFA-PLIINAKGTIVFTGSLAG-ICPFP-FGAVYSASKAAIHQYARVLHGELGPLGVRV 176
+ KG+++FT S++G I +P A Y A+KAA+ AR L E P RV
Sbjct: 129 QAAGHHFKKQGKGSLIFTASMSGHIANWPQQWASYHATKAAVKHLARALAVEWAPF-ARV 187
Query: 177 INMITGGVATDI 188
++ G + TD+
Sbjct: 188 NSVSPGYIDTDL 199
>Hs19923817 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/187 (25%), Positives = 80/187 (42%), Gaps = 13/187 (6%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPM----EELRAEFGD----RCIPRKLD 58
A+VTG ++GIG + KELL G V +R+ + +EL+A R IP + +
Sbjct: 21 AIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCN 80
Query: 59 VSNQNDITQL-KLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPIN 117
+ N+ ++ L K L+ K++ L NN G PA +S + N+ G
Sbjct: 81 IRNEEEVNNLVKSTLD---TFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFY 137
Query: 118 SCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVI 177
C+ + G + + FP A++A ++ + L E G+R I
Sbjct: 138 MCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIR-I 196
Query: 178 NMITGGV 184
N + GV
Sbjct: 197 NCVAPGV 203
>Hs19923983 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 313
Score = 50.8 bits (120), Expect = 2e-06
Identities = 55/227 (24%), Positives = 94/227 (41%), Gaps = 32/227 (14%)
Query: 8 LVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAE---FGDRCIPRKLDVSNQND 64
+VTGAS GIG + +L + G VY R + + E G +C+P D S +++
Sbjct: 11 VVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSSQESE 70
Query: 65 ITQLKLKLEQELPDQKLHLLYNNAGQSC------------SLPAI---DVSEEIIDNTFR 109
+ L ++++E +L +L NNA PA D++ + +
Sbjct: 71 VRSLFEQVDRE-QQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRGHYF 129
Query: 110 VNVYGPINSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGEL 169
+VYG A L++ A ++ S G + F Y KAA + A EL
Sbjct: 130 CSVYG--------ARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHEL 181
Query: 170 GPLGVRVINMITGGVATDI-----ADKKTLPEGSIFNFPEGIKAVET 211
GV +++ G V T++ A ++ L + + F + ET
Sbjct: 182 RRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAET 228
>CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 50.4 bits (119), Expect = 3e-06
Identities = 54/207 (26%), Positives = 85/207 (40%), Gaps = 24/207 (11%)
Query: 8 LVTGASSGIGYEVTKELLRRG--WYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQNDI 65
+VTGA+ GIG + ++L++ ++ A AR EL++ R L V+ +
Sbjct: 7 VVTGANRGIGLGLVQQLVKDKNIRHIIATARDVEKATELKSIKDSRVHVLPLTVTCDKSL 66
Query: 66 TQLKLKLEQELPDQKLHLLYNNAGQSCSLPA-IDVSEEIIDNTFRVNVYGPINSCREFAP 124
K+ + + L LL NNAG S + + +I VN + ++ P
Sbjct: 67 DTFVSKVGEIVGSDGLSLLINNAGVLLSYGTNTEPNRAVIAEQLDVNTTSVVLLTQKLLP 126
Query: 125 LIINA--------------------KGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARV 164
L+ NA G T + +G FP A Y SKAAI+ + R
Sbjct: 127 LLKNAASKESGDQLSVSRAAVITISSGLGSITDNTSGSAQFPVLA-YRMSKAAINMFGRT 185
Query: 165 LHGELGPLGVRVINMITGGVATDIADK 191
L +L V V+N G V T++ K
Sbjct: 186 LAVDLKDDNVLVVNFCPGWVQTNLGGK 212
>7304181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 331
Score = 50.4 bits (119), Expect = 3e-06
Identities = 56/203 (27%), Positives = 85/203 (41%), Gaps = 24/203 (11%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF-----GDRCIPRKLDV 59
K +VTGA++GIG E +E+ +RG VY R EE R E R+ D+
Sbjct: 46 KVFIVTGANTGIGKETVREIAKRGGTVYMACRNLKKCEEAREEIVLETKNKYVYCRQCDL 105
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAG-QSCSLPAIDVSEEIIDNTFRVNVYGP--- 115
++Q I ++E + LH+L NNAG C ++ + I+ VN G
Sbjct: 106 ASQESIRHFVAAFKRE--QEHLHVLINNAGVMRCPR---SLTSDGIELQLGVNHMGHFLL 160
Query: 116 ----INSCREFAP-LIINAKGTI-----VFTGSLAGICPFPFGAVYSASKAAIHQYARVL 165
++ ++ +P I+N + TG L + G YS SK A + R L
Sbjct: 161 TNLLLDLLKKSSPSRIVNVSSLAHTRGEINTGDLNSDKSYDEGKAYSQSKLANVLFTREL 220
Query: 166 HGELGPLGVRVINMITGGVATDI 188
L V + G V T+I
Sbjct: 221 AKRLEGTNVTANALHPGVVDTEI 243
>7304180 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 327
Score = 50.4 bits (119), Expect = 3e-06
Identities = 31/90 (34%), Positives = 45/90 (49%), Gaps = 7/90 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF-----GDRCIPRKLDV 59
K A+VTG ++G+G E EL RRG VY R +E R E R+ D+
Sbjct: 46 KVAIVTGGNTGLGKETVMELARRGATVYMACRNKEKVERARREIVKETGNSNVFSRECDL 105
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAG 89
S+ + I + ++E + LH+L NNAG
Sbjct: 106 SSLDSIRKFAENFKKE--QRVLHILINNAG 133
>7304177 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 300
Score = 50.4 bits (119), Expect = 3e-06
Identities = 54/204 (26%), Positives = 88/204 (42%), Gaps = 24/204 (11%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF-----GDRCIPRKLDV 59
K +VTGA++GIG E E+ +RG VY R + E+ R + R+LD+
Sbjct: 15 KVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQNIFSRELDL 74
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAG-QSCSLPAIDVSEEIIDNTFRVNVYGP--- 115
S+ I + ++E KLH+L NNAG C ++++ + VN G
Sbjct: 75 SSLESIRKFAAGFKKE--QDKLHVLINNAGVMHCPR---TLTKDGFEMQLGVNHMGHFLL 129
Query: 116 ----INSCREFAP-LIINAKGTI-----VFTGSLAGICPFPFGAVYSASKAAIHQYARVL 165
++ ++ AP I+N + + T L + YS SK A + R L
Sbjct: 130 THLLLDVLKKTAPSRIVNVSSLVHTQGFIKTADLNSEKSYSRIGAYSQSKLANVLFTREL 189
Query: 166 HGELGPLGVRVINMITGGVATDIA 189
L GV ++ G V T+++
Sbjct: 190 AKRLEGTGVTTNSLHPGAVDTELS 213
>CE19894 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 50.1 bits (118), Expect = 4e-06
Identities = 48/191 (25%), Positives = 82/191 (42%), Gaps = 4/191 (2%)
Query: 3 ETKYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQ 62
E K A+VT A+ GIG + + LL G V +R ++E ++ + + ++
Sbjct: 9 EGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAGH 68
Query: 63 NDITQLKLKLEQELPDQ--KLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYGPINSC 119
T + KL + K+++L NN G + + I +VS+++ D F VNV
Sbjct: 69 IASTDDQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQMT 128
Query: 120 REFAPLII-NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVIN 178
+ P I G I+F S + P A Y +K + R L L +RV
Sbjct: 129 KLVHPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIRVNG 188
Query: 179 MITGGVATDIA 189
+ G + T ++
Sbjct: 189 IAPGVIKTKMS 199
>CE13008 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 247
Score = 50.1 bits (118), Expect = 4e-06
Identities = 54/217 (24%), Positives = 88/217 (39%), Gaps = 33/217 (15%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF-------GDRCI--PR 55
K +VTG+SSGIG + G V R +E + + + C+
Sbjct: 7 KSVIVTGSSSGIGRATAVLFAKYGAQVTITGRDAGKLEATKKKMLKVMKNPENVCVVVAN 66
Query: 56 KLDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAI--DVSEEIIDNTFRVNVY 113
D Q++I Q L ++ +L NNAG + D S E+ TF++N
Sbjct: 67 LTDSDGQDEIVQSALDAFG-----RIDVLVNNAGANVVDGTFNTDQSTELYHKTFQINFE 121
Query: 114 GPINSCREFAPLIINAKGTIVFTGSLA----GICPFPFGAVYSASKAAIHQYARVLHGEL 169
I ++ +I +KG IV S+A + P P+ Y+ASKAA+ QY R +
Sbjct: 122 AVIEMVKKTKNHLIESKGEIVNVSSVAAGPQALAPSPY---YAASKAALDQYTRCV---- 174
Query: 170 GPLGVRVINMITGGVATDIADKKTLPEGSIFNFPEGI 206
+++I G+ + + + PE I
Sbjct: 175 ------ALDLILQGIEENFTSNRACIPAGVCGKPEDI 205
>At3g61220 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 50.1 bits (118), Expect = 4e-06
Identities = 42/147 (28%), Positives = 68/147 (45%), Gaps = 27/147 (18%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTH----PMEELRAEF---GDRCIPRKL 57
+YA+VTGA+ GIG+E+ ++L G V +R + +E L+ E + +L
Sbjct: 7 RYAVVTGANRGIGFEICRQLASEGIRVVLTSRDENRGLEAVETLKKELEISDQSLLFHQL 66
Query: 58 DVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVS-----------EEIIDN 106
DV++ IT L ++ + KL +L NNAG + + +EII
Sbjct: 67 DVADPASITSLAEFVKTQF--GKLDILVNNAGIGGIITDAEALRAGAGKEGFKWDEIITE 124
Query: 107 TF-------RVNVYGPINSCREFAPLI 126
T+ ++N YGP C F PL+
Sbjct: 125 TYELTEECIKINYYGPKRMCEAFIPLL 151
>At2g47140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 50.1 bits (118), Expect = 4e-06
Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 8/189 (4%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFG-DRCIPRKLDVSNQN 63
K ++TG +SGIG E + G V + + + G D+ DV+N+
Sbjct: 16 KIVIITGGASGIGAESVRLFTEHGARVVIVDVQDELGQNVAVSIGEDKASYYHCDVTNET 75
Query: 64 DITQ-LKLKLEQELPDQKLHLLYNNAGQSCSLPAI-DVSEEIIDNTFRVNVYGPINSCRE 121
++ +K +E+ KL +L++NAG +I D++ +D T +N+ G +
Sbjct: 76 EVENAVKFTVEKY---GKLDVLFSNAGVIEPFVSILDLNLNELDRTIAINLRGTAAFIKH 132
Query: 122 FAPLIINA--KGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINM 179
A ++ +G+IV T S+A Y+ SK + + G LG G+RV +
Sbjct: 133 AARAMVEKGIRGSIVCTTSVAAEIAGTAPHGYTTSKHGLLGLIKSASGGLGKYGIRVNGV 192
Query: 180 ITGGVATDI 188
GVAT +
Sbjct: 193 APFGVATPL 201
>7290386 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 176
Score = 50.1 bits (118), Expect = 4e-06
Identities = 50/168 (29%), Positives = 75/168 (43%), Gaps = 11/168 (6%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFG-DRCIPRKLDVSNQN 63
K ALVTGA SGIG + L R G V A R +E E G +R ++DVS+
Sbjct: 9 KVALVTGAGSGIGRATCRLLARDGAKVIAVDRNLKAAQETVQELGSERSAALEVDVSSAQ 68
Query: 64 DI---TQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVNVYGPINSCR 120
+ LK Q+ P ++ N+AG + + + E D+ + VN+ G +
Sbjct: 69 SVQFSVAEALKKFQQAPT----IVVNSAGITRDGYLLKMPERDYDDVYGVNLKGTFLVTQ 124
Query: 121 EFAPLIINAK---GTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVL 165
+A +I K GTIV S+ A Y+A+KA + + L
Sbjct: 125 AYAKAMIEQKLENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTERL 172
>Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 310
Score = 49.7 bits (117), Expect = 5e-06
Identities = 46/172 (26%), Positives = 84/172 (48%), Gaps = 13/172 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQND 64
++A++TGA GIG + EL +RG V +R +E + E +R R + + Q D
Sbjct: 49 QWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEI-ERTTGRSVKII-QAD 106
Query: 65 ITQ--LKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEI-IDNTFRVNVYGPINSCRE 121
T+ + ++++L ++ +L NN G LP + S + + + ++ I S +
Sbjct: 107 FTKDDIYEHIKEKLAGLEIGILVNNVGM---LPNLLPSHFLNAPDEIQSLIHCNITSVVK 163
Query: 122 FAPLII-----NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGE 168
LI+ KG I+ S + P+P ++YSASKA + +++ L E
Sbjct: 164 MTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEE 215
>Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 318
Score = 49.7 bits (117), Expect = 5e-06
Identities = 42/190 (22%), Positives = 78/190 (40%), Gaps = 2/190 (1%)
Query: 6 YALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLDVSNQNDI 65
+ +TG SG G + +L ++ + V A E+L+ LD+++
Sbjct: 30 FVFITGCDSGFGRLLALQLDQKSFRVLASCLTPSGAEDLQGVASSGFNTTLLDITDPQSF 89
Query: 66 TQLKLKLEQELPDQKLHLLYNNAGQSCSL-PAIDVSEEIIDNTFRVNVYGPINSCREFAP 124
Q +E + + L L NNAG + + P ++ + VN GPI P
Sbjct: 90 QQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLALLP 149
Query: 125 LIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVRVINMITGGV 184
L+ A+G ++ S+ G G Y SK + ++ L ++ G+R + G
Sbjct: 150 LLQQARGRVINITSVLGRLA-ANGGGYCVSKFGLEAFSDSLRRDVAHFGIRESIVEPGFF 208
Query: 185 ATDIADKKTL 194
T + + ++L
Sbjct: 209 RTPVTNLESL 218
>7304178 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 49.7 bits (117), Expect = 5e-06
Identities = 32/90 (35%), Positives = 41/90 (45%), Gaps = 7/90 (7%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF-----GDRCIPRKLDV 59
+ A+VTG + GIG E EL RRG VY R E R E R+LD+
Sbjct: 15 RVAIVTGCNQGIGKETVLELARRGATVYMACRDMKKCENARREIIKATNNQNIFARQLDL 74
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAG 89
+ I ++E KLH+L NNAG
Sbjct: 75 CSMKSIRNFAAGFKRE--QNKLHILINNAG 102
>7290936 [Q] KOG1204 Predicted dehydrogenase
Length = 261
Score = 49.7 bits (117), Expect = 5e-06
Identities = 52/202 (25%), Positives = 86/202 (41%), Gaps = 15/202 (7%)
Query: 1 MSETKYALVTGASSGIGYEVTKELLRR----GWYVYACARRTHPMEELRAEF-------G 49
+ + Y LVTGAS GIG E ++L +R G V R ++E +AE
Sbjct: 3 LKQRTYLLVTGASRGIGREFAQQLAKRIKAEGSMVTLLGRNQTLLQESKAEIVATVPDLS 62
Query: 50 DRCIPRKLDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQ--SCSLPAIDVSE-EIIDN 106
+ +L+ + D T++ L+ + + ++ +NAG S A ++ + + +
Sbjct: 63 VQTYSLELETAKTEDFTKI-LEASGGKNNFERAIVIHNAGTVGDTSKRAKEIGDTDFLQR 121
Query: 107 TFRVNVYGPINSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLH 166
+ NV+ I+ EF + +V +LA I P A Y KAA Y RVL
Sbjct: 122 YYHSNVFSAISLNCEFMRVFKGIPKLVVNLSTLAAIAPISSMAHYCTVKAAREMYFRVLA 181
Query: 167 GELGPLGVRVINMITGGVATDI 188
E V+N G + T +
Sbjct: 182 TEESAEDTLVLNYAPGVIDTQM 203
>SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase
Length = 247
Score = 49.3 bits (116), Expect = 7e-06
Identities = 50/174 (28%), Positives = 75/174 (42%), Gaps = 13/174 (7%)
Query: 1 MSET--KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEFGDRCIPRKLD 58
M+ET K L+TG+S GIG + L ++ + T +E L + D + K D
Sbjct: 1 MAETAEKVILLTGSSKGIGLATAEALQKKAKVIAVSRSLTPELETLLIQNPDSFVHVKGD 60
Query: 59 VSNQNDITQLKLKLEQELPD-QKLHLLYNNAGQSCSLPAI---DVSEEIIDNTFRVNVYG 114
V+ K +E + KL + NAG + I D++E F +N +
Sbjct: 61 VTEVG-----KASIETAIKKFGKLDSVILNAGVLEPIAKIADADINEW--RKLFDINFFS 113
Query: 115 PINSCREFAPLIINAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGE 168
+ + + P + KGTIV S A + FP A Y SKAAI+ L E
Sbjct: 114 VVETVKYAIPHLRKTKGTIVIVSSGAAVRVFPAWAAYCCSKAAINMLVMNLGSE 167
>CE21514 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 319
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/210 (26%), Positives = 90/210 (42%), Gaps = 31/210 (14%)
Query: 7 ALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEELRAEF---------------GDR 51
A+VTGAS GIG + +L G VY R+ P E L ++ G +
Sbjct: 8 AIVTGASRGIGRGIALQLGEAGATVYITGRK--PEESLNSKVGLSGLEATADEITKRGGK 65
Query: 52 CIPRKLDVSNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDVSEEIIDNTFRVN 111
I R +D N ++ +E+E Q L +L NNA Q + + ++ + +
Sbjct: 66 GIARFVDHQNMEEVKNFFEVVEKEHQGQ-LDILVNNAYQGVTAISENMGKPFYETD--PY 122
Query: 112 VYGPINS--------CREFAPLIINA--KGTIVFTGSLAGICPFPFGAVYSASKAAIHQY 161
V+ IN+ C +A ++ A KG IV S G+ + F Y K A+ +
Sbjct: 123 VWDTINNVGLRNHYFCTVYAARLMTARNKGLIVNVSSGGGL-RYLFNVAYGVGKQALDRM 181
Query: 162 ARVLHGELGPLGVRVINMITGGVATDIADK 191
+ EL V V+++ G V T++ DK
Sbjct: 182 SADTAVELRKKNVCVVSIWPGAVRTELVDK 211
>At1g52340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 285
Score = 48.9 bits (115), Expect = 9e-06
Identities = 58/194 (29%), Positives = 84/194 (42%), Gaps = 12/194 (6%)
Query: 5 KYALVTGASSGIGYEVTKELLRRGWYVYACARRTHPMEE-----LRAEFGDRCIPRKLDV 59
K AL+TG ++GIG + + + G V + E LR E + DV
Sbjct: 21 KVALITGGATGIGESIVRLFHKHGAKVCIVDLQDDLGGEVCKSLLRGESKETAFFIHGDV 80
Query: 60 SNQNDITQLKLKLEQELPDQKLHLLYNNAGQSCSLPAIDV---SEEIIDNTFRVNVYGPI 116
++DI+ + L +L NNAG C P D+ S + TF VNV G
Sbjct: 81 RVEDDISNAVDFAVKNFGT--LDILINNAGL-CGAPCPDIRNYSLSEFEMTFDVNVKGAF 137
Query: 117 NSCREFAPLII-NAKGTIVFTGSLAGICPFPFGAVYSASKAAIHQYARVLHGELGPLGVR 175
S + A ++I KG+IV S+ G+ Y SK A+ R + ELG G+R
Sbjct: 138 LSMKHAARVMIPEKKGSIVSLCSVGGVVGGVGPHSYVGSKHAVLGLTRSVAAELGQHGIR 197
Query: 176 VINMITGGVATDIA 189
V + VAT +A
Sbjct: 198 VNCVSPYAVATKLA 211
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.137 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,224,883
Number of Sequences: 60738
Number of extensions: 739587
Number of successful extensions: 2281
Number of sequences better than 1.0e-05: 158
Number of HSP's better than 0.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 146
Number of HSP's that attempted gapping in prelim test: 2081
Number of HSP's gapped (non-prelim): 166
length of query: 305
length of database: 30,389,216
effective HSP length: 106
effective length of query: 199
effective length of database: 23,950,988
effective search space: 4766246612
effective search space used: 4766246612
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)