ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI1231 good G KOG0450 Carbohydrate transport and metabolism 2-oxoglutarate dehydrogenase, E1 subunit
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI1231 432785 429735 -1017
(1017 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIL125w [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 1647 0.0
SPBC3H7.03c [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 1209 0.0
At5g65750 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 960 0.0
At3g55410 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 927 0.0
7294032 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 852 0.0
Hs20541592 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 840 0.0
CE28486 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 837 0.0
Hs4505493 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 836 0.0
Hs8922716 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 808 0.0
7292108 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit 745 0.0
Hs18375678 [G] KOG0451 Predicted 2-oxoglutarate dehydrogenase E1... 566 e-161
CE23468 [G] KOG0451 Predicted 2-oxoglutarate dehydrogenase E1 su... 559 e-159
7302023 [G] KOG0451 Predicted 2-oxoglutarate dehydrogenase E1 su... 508 e-143
>YIL125w [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1014
Score = 1647 bits (4264), Expect = 0.0
Identities = 799/1019 (78%), Positives = 900/1019 (87%), Gaps = 8/1019 (0%)
Query: 1 MLRTIRSSQRLLHASK-FTRIGAVSKPTSLAVFSRGLASGASSTDNFLSTTNASYIDEMY 59
MLR + SSQ ++S+ + + +++ + RGLA+ + TDNFLST+NA+YIDEMY
Sbjct: 1 MLRFV-SSQTCRYSSRGLLKTSLLKNASTVKIVGRGLAT--TGTDNFLSTSNATYIDEMY 57
Query: 60 EAWQKDPTSVHVSWDAYFKNMGNLNIPASSAFTAXXXXXXXXXXXXXXQDILIGGSLSG- 118
+AWQKDP+SVHVSWDAYFKNM N IPA+ AF A +G +++G
Sbjct: 58 QAWQKDPSSVHVSWDAYFKNMSNPKIPATKAFQAPPSISNFPQGTEAAP---LGTAMTGS 114
Query: 119 VDQDITTHLKVQLLCRAYQVRGHQKAHIDPLQISFGDDKSKPLPRELTLEHYGFTEKDLD 178
VD++++ HLKVQLLCRAYQVRGH KAHIDPL ISFG +K+ P+P ELTL++YGF++ DLD
Sbjct: 115 VDENVSIHLKVQLLCRAYQVRGHLKAHIDPLGISFGSNKNNPVPPELTLDYYGFSKHDLD 174
Query: 179 RDITLGPGILPRFSRDGRKTMKLREIIAALEKLYCSGYGIEYIHIPSKEQCEWLRERIEI 238
++I LGPGILPRF+RDG+ M L+EI+ LEKLYCS YG++Y HIPSK++C+WLRERIEI
Sbjct: 175 KEINLGPGILPRFARDGKSKMSLKEIVDHLEKLYCSSYGVQYTHIPSKQKCDWLRERIEI 234
Query: 239 PQPYNYTVDQKRQILDRLTWATSFETFLSTKFPNDKRFGLEGLEGVVPGIKTLIDRSVEL 298
P+PY YTVDQKRQILDRLTWATSFE+FLSTKFPNDKRFGLEGLE VVPGIKTL+DRSVEL
Sbjct: 235 PEPYQYTVDQKRQILDRLTWATSFESFLSTKFPNDKRFGLEGLESVVPGIKTLVDRSVEL 294
Query: 299 GVEDVVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSVAPEEYEGSGDVKYHLGMNYQRPT 358
GVED+VLGMAHRGRLNVLSNVVRKPNESIFSEFKGS A ++ EGSGDVKYHLGMNYQRPT
Sbjct: 295 GVEDIVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSSARDDIEGSGDVKYHLGMNYQRPT 354
Query: 359 TSGKYVNLSLVANPSHLEAADPVVLGRTRAIQFSKNDIGKYDKAISVLLHGDAAFAAQGI 418
TSGKYVNLSLVANPSHLE+ DPVVLGRTRA+ +KND+ + KA+ VLLHGDAAFA QG+
Sbjct: 355 TSGKYVNLSLVANPSHLESQDPVVLGRTRALLHAKNDLKEKTKALGVLLHGDAAFAGQGV 414
Query: 419 VYETMGFLHLPAYSTGGTIHVITNNQIGFTTDPRFARSTLYPSDLGKTIDAPIFHVNAND 478
VYETMGFL LP YSTGGTIHVITNNQIGFTTDPRFARST YPSDL K IDAPIFHVNAND
Sbjct: 415 VYETMGFLTLPEYSTGGTIHVITNNQIGFTTDPRFARSTPYPSDLAKAIDAPIFHVNAND 474
Query: 479 VEALTFIFNLAAEWRATFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYQKISKQKSVIDV 538
VEA+TFIFNLAAEWR FHTDAIIDVVGWRKHGHNETDQPSFTQPLMY+KI+KQKSVIDV
Sbjct: 475 VEAVTFIFNLAAEWRHKFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYKKIAKQKSVIDV 534
Query: 539 YTEKLVSEGSFTKQDIDEHKKWVWGLFEEAYEKAKDYKPTSREWLTAAWEGFKSPKALAT 598
YTEKL+SEG+F+K+DIDEHKKWVW LFE+A+EKAKDY P+ REWLTAAWEGFKSPK LAT
Sbjct: 535 YTEKLISEGTFSKKDIDEHKKWVWNLFEDAFEKAKDYVPSQREWLTAAWEGFKSPKELAT 594
Query: 599 EILSHEPTVVDADTLKNIGKTISSWPENFEVHKNLKRILTNRGKAVESGEGIDWSTGEAL 658
EIL HEPT V TLK +GK +SSWPE FEVHKNLKRIL NRGK++E+GEGIDW+TGEAL
Sbjct: 595 EILPHEPTNVPESTLKELGKVLSSWPEGFEVHKNLKRILKNRGKSIETGEGIDWATGEAL 654
Query: 659 AFGSLVLEGNHVRVSGEDVERGTFSQRHAVLHDQKSENTYTPLKHLSEKQANFTICNSSL 718
AFG+LVL+G +VRVSGEDVERGTFSQRHAVLHDQ+SE YTPL L+ ++A+FTI NSSL
Sbjct: 655 AFGTLVLDGQNVRVSGEDVERGTFSQRHAVLHDQQSEAIYTPLSTLNNEKADFTIANSSL 714
Query: 719 SEYGCMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVIIDQFIAAGEVKWKQRSGLVLSLP 778
SEYG MGFEYGYSLT+PDY V+WEAQFGDFANTAQVIIDQFIA GE KWKQRSGLVLSLP
Sbjct: 715 SEYGVMGFEYGYSLTSPDYLVMWEAQFGDFANTAQVIIDQFIAGGEQKWKQRSGLVLSLP 774
Query: 779 HGYDGQGPEHSSGRLERFLQLGNEDPRYFPSEEKLQRQHQDCNFQIVYPTTPANLFHILR 838
HGYDGQGPEHSSGRLERFLQL NEDPRYFPSEEKLQRQHQDCNFQ+VYPTTPANLFHILR
Sbjct: 775 HGYDGQGPEHSSGRLERFLQLANEDPRYFPSEEKLQRQHQDCNFQVVYPTTPANLFHILR 834
Query: 839 RQQHRQFRKPLALFFSKQLLRHPLARSNLNEFTEGGFQWIIEDVELGKSIAPKEEIKRVV 898
RQQHRQFRKPLALFFSKQLLRHPLARS+L+EFTEGGFQWIIED+E GKSI KEE KR+V
Sbjct: 835 RQQHRQFRKPLALFFSKQLLRHPLARSSLSEFTEGGFQWIIEDIEHGKSIGTKEETKRLV 894
Query: 899 LLSGQVYTALHKKRETIQDKNTAFIKIEQLHPFPYAQLRDALNTYPNLEDIVWCQEEPLN 958
LLSGQVYTALHK+RE++ DK TAF+KIEQLHPFP+AQLRD+LN+YPNLE+IVWCQEEPLN
Sbjct: 895 LLSGQVYTALHKRRESLGDKTTAFLKIEQLHPFPFAQLRDSLNSYPNLEEIVWCQEEPLN 954
Query: 959 MGGWAYAQPRLQTTLKETDKYKDAIIRYAGRNPSGSVAAGSKALHNAEEEAFLKEVFGQ 1017
MG WAY +PRL TTLKETDKYKD +RY GRNPSG+VAAGSK+LH AEE+AFLK+VF Q
Sbjct: 955 MGSWAYTEPRLHTTLKETDKYKDFKVRYCGRNPSGAVAAGSKSLHLAEEDAFLKDVFQQ 1013
>SPBC3H7.03c [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1009
Score = 1209 bits (3127), Expect = 0.0
Identities = 596/1016 (58%), Positives = 745/1016 (72%), Gaps = 13/1016 (1%)
Query: 1 MLRTIRSSQ--RLLHASKFTRIGAVSKPTSLAVFSRGLASGASSTDNFLSTTNASYIDEM 58
MLR I SS R L S T +++ T L+ + TD+FL+ A Y+DEM
Sbjct: 1 MLRFIPSSAKARALRRSAVTAY-RLNRLTCLSSLQQNRTFATQPTDDFLTGGAADYVDEM 59
Query: 59 YEAWQKDPTSVHVSWDAYFKNMGNLNIPASSAFTAXXXXXXXXXXXXXXQDILIGGSLSG 118
Y+AW+KDP SVH SW AYFKN+ + S AF A ++ G + +
Sbjct: 60 YDAWKKDPNSVHASWQAYFKNVQERGVSPSKAFQAPPLLDYADSYTALDSSLINGNNYAD 119
Query: 119 VDQDITTHLKVQLLCRAYQVRGHQKAHIDPLQISFGDDKSKPLPRELTLEHYGFTEKDLD 178
+D I ++KVQLL RAYQ RGH A +DPL I+ ++ P ELTLEHYGFTE DL+
Sbjct: 120 IDVGI--YMKVQLLVRAYQSRGHHLAKLDPLGINVNHNR----PSELTLEHYGFTESDLN 173
Query: 179 RDITLGPGILPRFSRDGRKTMKLREIIAALEKLYCSGYGIEYIHIPSKEQCEWLRERIEI 238
R I LGPGILP F GRKTM LREI+ EK+YC + +E+ HI S+++ W+ +E
Sbjct: 174 RTIHLGPGILPNFREAGRKTMTLREIVETCEKIYCGSFAVEFTHISSRKRSNWILSHLET 233
Query: 239 PQPYNYTVDQKRQILDRLTWATSFETFLSTKFPNDKRFGLEGLEGVVPGIKTLIDRSVEL 298
P P+ Y+ DQK I DRL+WA SFE FL TKFPNDKRFGLEG E +VPG+K LIDRSV+
Sbjct: 234 PTPFRYSHDQKIMIFDRLSWADSFERFLFTKFPNDKRFGLEGCEAMVPGMKALIDRSVDE 293
Query: 299 GVEDVVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSVAPEEYEGSGDVKYHLGMNYQRPT 358
G+ ++V+GMAHRGRLN+L N+VRKP ++IFSEF+G+ P++ EGSGDVKYHLGMNYQRPT
Sbjct: 294 GISNIVIGMAHRGRLNLLHNIVRKPAQAIFSEFRGTQDPDD-EGSGDVKYHLGMNYQRPT 352
Query: 359 TSGKYVNLSLVANPSHLEAADPVVLGRTRAIQFSKNDIGKYDKAISVLLHGDAAFAAQGI 418
SGK V+LSLVANPSHLEA DPVVLG+ RAIQ +D +++++ +L+HGDAAFAAQG+
Sbjct: 353 PSGKRVSLSLVANPSHLEAEDPVVLGKVRAIQHYTSDEASHEQSMGILIHGDAAFAAQGV 412
Query: 419 VYETMGFLHLPAYSTGGTIHVITNNQIGFTTDPRFARSTLYPSDLGKTIDAPIFHVNAND 478
VYET G LP YSTGGT+H++ NNQIGFTTDPRFARST Y +D+ K+++APIFHVN +D
Sbjct: 413 VYETFGLHALPGYSTGGTVHIVINNQIGFTTDPRFARSTPYCTDIAKSMEAPIFHVNGDD 472
Query: 479 VEALTFIFNLAAEWRATFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYQKISKQKSVIDV 538
VEA+TFI LAA+WR F TD ++D+V +R+HGHNETDQPSFTQP MY+ I+K +
Sbjct: 473 VEAVTFICQLAADWRKAFKTDVVVDIVCYRRHGHNETDQPSFTQPRMYKAIAKHPPTFKI 532
Query: 539 YTEKLVSEGSFTKQDIDEHKKWVWGLFEEAYEKAKDYKPTSREWLTAAWEGFKSPKALAT 598
YT++L+ E + +K ++D +K VW + E ++E +K+YK REWL+ W GF SPK L T
Sbjct: 533 YTQQLLQEKTVSKAEVDAQEKRVWDILESSFESSKNYKSDHREWLSNPWVGFASPKDLMT 592
Query: 599 EILSHEPTVVDADTLKNIGKTISSWPENFEVHKNLKRILTNRGKAVESGEGIDWSTGEAL 658
+IL PT V+ DTLK IGK + + PE F+ H+NLKRIL NR K++ SGEGID T EAL
Sbjct: 593 KILPSYPTGVNIDTLKQIGKALYTLPEGFDAHRNLKRILNNRNKSISSGEGIDMPTAEAL 652
Query: 659 AFGSLVLEGNHVRVSGEDVERGTFSQRHAVLHDQKSENTYTPLKHLSEKQANFTICNSSL 718
AFG+L+ EG+HVRVSG+DVERGTFSQRHAVLHDQ SEN Y PL HLS QA+F I NSSL
Sbjct: 653 AFGTLLEEGHHVRVSGQDVERGTFSQRHAVLHDQSSENVYIPLNHLSPNQASFVIRNSSL 712
Query: 719 SEYGCMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVIIDQFIAAGEVKWKQRSGLVLSLP 778
SEYG +GFEYGYSL++P+ VVWEAQFGDFAN AQ IIDQFIAAGE KW QR+G+VLSLP
Sbjct: 713 SEYGVLGFEYGYSLSSPNALVVWEAQFGDFANNAQCIIDQFIAAGETKWLQRTGIVLSLP 772
Query: 779 HGYDGQGPEHSSGRLERFLQLGNEDPRYFPSEEKLQRQHQDCNFQIVYPTTPANLFHILR 838
HGYDGQGPEHSS R+ER+LQL NEDPR FPSEEKLQRQHQDCN Q +Y T P+ FH LR
Sbjct: 773 HGYDGQGPEHSSARMERYLQLCNEDPREFPSEEKLQRQHQDCNIQAIYVTKPSQYFHALR 832
Query: 839 RQQHRQFRKPLALFFSKQLLRHPLARSNLNEFTE-GGFQWIIEDVELGKSIAPKEEIKRV 897
R HRQFRKPL +FFSK LLRHP ARS ++EF E GF+ I+E+ E GKSI P E+I+++
Sbjct: 833 RNIHRQFRKPLVIFFSKSLLRHPAARSTIDEFDEKHGFKLILEEEEHGKSILPPEKIEKL 892
Query: 898 VLLSGQVYTALHKKRETIQDKNTAFIKIEQLHPFPYAQLRDALNTYPNLEDIVWCQEEPL 957
++ SGQV+ AL K RE + N A ++EQLHPF + Q+ ++ YPNL++I+WCQEEPL
Sbjct: 893 IICSGQVWVALSKAREENKIDNIAITRVEQLHPFGWKQMAANISQYPNLKEIIWCQEEPL 952
Query: 958 NMGGWAYAQPRLQTTLKETDKYKDAIIRYAGRNPSGSVAAGSKALHNAEEEAFLKE 1013
N G W Y +PR+ T LK +D +RYAGR PS SVAAG+K H AE+E FL +
Sbjct: 953 NAGAWTYMEPRIYTILKHLG--RDLPVRYAGRPPSASVAAGNKQQHLAEQEQFLND 1006
>At5g65750 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1025
Score = 960 bits (2481), Expect = 0.0
Identities = 490/989 (49%), Positives = 655/989 (65%), Gaps = 59/989 (5%)
Query: 43 TDNFLSTTNASYIDEMYEAWQKDPTSVHVSWDAYFKNMGNLNIPASSAFTAXXXXXXXXX 102
TD+FL T++ Y++E+ AW+ DP SV SWD +F+N A T+
Sbjct: 66 TDSFLDGTSSVYLEELQRAWEADPNSVDESWDNFFRNF------VGQASTSP-------- 111
Query: 103 XXXXXQDILIGGSLSGVDQDITTHLKVQLLCRAYQVRGHQKAHIDPLQISFGDDKSKPLP 162
+SG Q I +++ LL RAYQV GH KA +DPL + + + +P
Sbjct: 112 ------------GISG--QTIQESMRLLLLVRAYQVNGHMKAKLDPLGL-----EKREIP 152
Query: 163 RELTLEHYGFTEKDLDRDITLGPGILPRFSRDGRKTMKLREIIAALEKLYCSGYGIEYIH 222
+LT YGFTE DLDR+ LG + F + R LR I++ LE+ YC G EY+H
Sbjct: 153 EDLTPGLYGFTEADLDREFFLGVWRMSGFLSENRPVQTLRSILSRLEQAYCGTIGYEYMH 212
Query: 223 IPSKEQCEWLRERIEIPQPYNYTVDQKRQILDRLTWATSFETFLSTKFPNDKRFGLEGLE 282
I +++C WLR++IE P P Y +++ I DRLTW+T FE FL+TK+ KRFGLEG E
Sbjct: 213 IADRDKCNWLRDKIETPTPRQYNSERRMVIYDRLTWSTQFENFLATKWTTAKRFGLEGAE 272
Query: 283 GVVPGIKTLIDRSVELGVEDVVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSVAPEE--- 339
++PG+K + DRS +LGVE++V+GM HRGRLNVL NVVRKP IFSEF G P +
Sbjct: 273 SLIPGMKEMFDRSADLGVENIVIGMPHRGRLNVLGNVVRKPLRQIFSEFSGGTRPVDEVG 332
Query: 340 -YEGSGDVKYHLGMNYQRPTTSGKYVNLSLVANPSHLEAADPVVLGRTRAIQFSKNDIGK 398
Y G+GDVKYHLG +Y RPT GK+++LSLVANPSHLEA DPVV+G+TRA Q+ D +
Sbjct: 333 LYTGTGDVKYHLGTSYDRPTRGGKHLHLSLVANPSHLEAVDPVVIGKTRAKQYYTKDENR 392
Query: 399 YDKAISVLLHGDAAFAAQGIVYETMGFLHLPAYSTGGTIHVITNNQIGFTTDPRFARSTL 458
K + +L+HGD +FA QG+VYET+ LP Y TGGT+H++ NNQ+ FTTDPR RS+
Sbjct: 393 -TKNMGILIHGDGSFAGQGVVYETLHLSALPNYCTGGTVHIVVNNQVAFTTDPREGRSSQ 451
Query: 459 YPSDLGKTIDAPIFHVNANDVEALTFIFNLAAEWRATFHTDAIIDVVGWRKHGHNETDQP 518
Y +D+ K + APIFHVNA+D+EA+ LAAEWR TFH+D ++D+V +R+ GHNE D+P
Sbjct: 452 YCTDVAKALSAPIFHVNADDIEAVVHACELAAEWRQTFHSDVVVDLVCYRRFGHNEIDEP 511
Query: 519 SFTQPLMYQKISKQKSVIDVYTEKLVSEGSFTKQDIDEHKKWVWGLFEEAYEKAKDYKPT 578
SFTQP MY+ I S + +Y EKL+ G T++DID+ +K V + E YE +KDY P
Sbjct: 512 SFTQPKMYKVIRSHPSSLQIYQEKLLQSGQVTQEDIDKIQKKVSSILNEEYEASKDYIPQ 571
Query: 579 SREWLTAAWEGFKSPKALATEILSHEPTVVDADTLKNIGKTISSWPENFEVHKNLKRILT 638
R+WL + W GFKSP+ +I T V + LKN+GK IS++PENF+ H+ +KR+
Sbjct: 572 KRDWLASHWTGFKSPE----QISRIRNTGVKPEILKNVGKAISTFPENFKPHRGVKRVYE 627
Query: 639 NRGKAVESGEGIDWSTGEALAFGSLVLEGNHVRVSGEDVERGTFSQRHAVLHDQKSENTY 698
R + +ESGEGIDW GEALAF +LV+EGNHVR+SG+DVERGTFS RH+VLHDQ++ Y
Sbjct: 628 QRAQMIESGEGIDWGLGEALAFATLVVEGNHVRLSGQDVERGTFSHRHSVLHDQETGEEY 687
Query: 699 TPLKHLSEKQ--ANFTICNSSLSEYGCMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVII 756
PL HL + Q FT+ NSSLSE+G +GFE GYS+ NP+ V+WEAQFGDFAN AQV+
Sbjct: 688 CPLDHLIKNQDPEMFTVSNSSLSEFGVLGFELGYSMENPNSLVIWEAQFGDFANGAQVMF 747
Query: 757 DQFIAAGEVKWKQRSGLVLSLPHGYDGQGPEHSSGRLERFLQLGNEDPRYFPS-EEKLQR 815
DQFI++GE KW +++GLV+ LPHGYDGQGPEHSSGRLERFLQ+ +++P P + L++
Sbjct: 748 DQFISSGEAKWLRQTGLVVLLPHGYDGQGPEHSSGRLERFLQMSDDNPYVIPEMDPTLRK 807
Query: 816 QHQDCNFQIVYPTTPANLFHILRRQQHRQFRKPLALFFSKQLLRHPLARSNLNEFTE--- 872
Q Q+CN+Q+V TTPAN FH+LRRQ HR FRKPL + K LLRH SNL+EF +
Sbjct: 808 QIQECNWQVVNVTTPANYFHVLRRQIHRDFRKPLIVMAPKNLLRHKQCVSNLSEFDDVKG 867
Query: 873 --------GGFQWIIEDVELGKSIAPKEEIKRVVLLSGQVYTALHKKRETIQDKNTAFIK 924
F+ +I+D + +E I+R+VL SG+VY L ++R+ + K+ A +
Sbjct: 868 HPGFDKQGTRFKRLIKDQSGHSDL--EEGIRRLVLCSGKVYYELDEERKKSETKDVAICR 925
Query: 925 IEQLHPFPYAQLRDALNTYPNLEDIVWCQEEPLNMGGWAYAQPRLQTTLKETDKYKDAII 984
+EQL PFPY ++ L YPN E IVWCQEEP+NMGG+ Y RL T +K + I
Sbjct: 926 VEQLCPFPYDLIQRELKRYPNAE-IVWCQEEPMNMGGYQYIALRLCTAMKALQRGNFNDI 984
Query: 985 RYAGRNPSGSVAAGSKALHNAEEEAFLKE 1013
+Y GR PS + A G LH E+ +K+
Sbjct: 985 KYVGRLPSAATATGFYQLHVKEQTDLVKK 1013
>At3g55410 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1009
Score = 927 bits (2395), Expect = 0.0
Identities = 484/1032 (46%), Positives = 660/1032 (63%), Gaps = 73/1032 (7%)
Query: 3 RTIRSSQRLLHASKFTRIGAVSKPTSLAVFSRGLASGASSTDNFLSTTNASYIDEMYEAW 62
R+I S R H S R A S P AV L TD+FL T++ Y++E+ AW
Sbjct: 30 RSIPSQTRSFH-STICRPKAQSAPVPRAVPLSKL------TDSFLDGTSSVYLEELQRAW 82
Query: 63 QKDPTSVHVSWDAYFKNMGNLNIPASSAFTAXXXXXXXXXXXXXXQDILIGGSLSGVDQD 122
+ DP SV SWD +F+N A T+ +SG Q
Sbjct: 83 EADPNSVDESWDNFFRNF------VGQAATSP--------------------GISG--QT 114
Query: 123 ITTHLKVQLLCRAYQVRGHQKAHIDPLQISFGDDKSKPLPRELTLEHYGFTEKDLDRDIT 182
I +++ LL RAYQV GH KA +DPL + + + +P +L L YGFTE DLDR+
Sbjct: 115 IQESMRLLLLVRAYQVNGHMKAKLDPLGL-----EQREIPEDLDLALYGFTEADLDREFF 169
Query: 183 LGPGILPRFSRDGRKTMKLREIIAALEKLYCSGYGIEYIHIPSKEQCEWLRERIEIPQPY 242
LG + F + R LR I+ LE+ YC G EY+HI +++C WLRE+IE P P+
Sbjct: 170 LGVWQMSGFMSENRPVQTLRSILTRLEQAYCGNIGFEYMHIADRDKCNWLREKIETPTPW 229
Query: 243 NYTVDQKRQILDRLTWATSFETFLSTKFPNDKRFGLEGLEGVVPGIKTLIDRSVELGVED 302
Y +++ ILDRL W+T FE FL+TK+ KRFGLEG E ++PG+K + DR+ +LGVE
Sbjct: 230 RYNRERREVILDRLAWSTQFENFLATKWTTAKRFGLEGGESLIPGMKEMFDRAADLGVES 289
Query: 303 VVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSVAPEE---YEGSGDVKYHLGMNYQRPTT 359
+V+GM+HRGRLNVL NVVRKP IFSEF G + P + Y G+GDVKYHLG +Y RPT
Sbjct: 290 IVIGMSHRGRLNVLGNVVRKPLRQIFSEFSGGIRPVDEVGYTGTGDVKYHLGTSYDRPTR 349
Query: 360 SGKYVNLSLVANPSHLEAADPVVLGRTRAIQFSKNDIGKYDKAISVLLHGDAAFAAQGIV 419
GK ++LSLVANPSHLEAAD VV+G+TRA Q+ ND+ + K + +L+HGD +FA QG+V
Sbjct: 350 GGKKIHLSLVANPSHLEAADSVVVGKTRAKQYYSNDLDR-TKNLGILIHGDGSFAGQGVV 408
Query: 420 YETMGFLHLPAYSTGGTIHVITNNQIGFTTDPRFARSTLYPSDLGKTIDAPIFHVNANDV 479
YET+ LP Y+TGGTIH++ NNQ+ FTTDPR RS+ Y +D+ K + APIFHVN +DV
Sbjct: 409 YETLHLSALPNYTTGGTIHIVVNNQVAFTTDPRAGRSSQYCTDVAKALSAPIFHVNGDDV 468
Query: 480 EALTFIFNLAAEWRATFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYQKISKQKSVIDVY 539
EA+ LAAEWR TFH+D ++D+V +R+ GHNE D+PSFTQP MY+ I S + +Y
Sbjct: 469 EAVVHACELAAEWRQTFHSDVVVDLVCYRRFGHNEIDEPSFTQPKMYKVIKNHPSTLQIY 528
Query: 540 TEKLVSEGSFTKQDIDEHKKWVWGLFEEAYEKAKDYKPTSREWLTAAWEGFKSPKALATE 599
+KL+ G ++QDID ++ V + E + +KDY P R+WL+ W GFKSP+ +
Sbjct: 529 HKKLLECGEVSQQDIDRIQEKVNTILNEEFVASKDYLPKKRDWLSTNWAGFKSPE----Q 584
Query: 600 ILSHEPTVVDADTLKNIGKTISSWPENFEVHKNLKRILTNRGKAVESGEGIDWSTGEALA 659
I T V + LK +GK ISS PENF+ H+ +K++ R + +ESGEG+DW+ EALA
Sbjct: 585 ISRVRNTGVKPEILKTVGKAISSLPENFKPHRAVKKVYEQRAQMIESGEGVDWALAEALA 644
Query: 660 FGSLVLEGNHVRVSGEDVERGTFSQRHAVLHDQKSENTYTPLKHL--SEKQANFTICNSS 717
F +LV+EGNHVR+SG+DVERGTFS RH+VLHDQ++ Y PL HL ++ FT+ NSS
Sbjct: 645 FATLVVEGNHVRLSGQDVERGTFSHRHSVLHDQETGEEYCPLDHLIMNQDPEMFTVSNSS 704
Query: 718 LSEYGCMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVIIDQFIAAGEVKWKQRSGLVLSL 777
LSE+G +GFE GYS+ +P+ V+WEAQFGDFAN AQVI DQFI++GE KW +++GLV+ L
Sbjct: 705 LSEFGVLGFELGYSMESPNSLVLWEAQFGDFANGAQVIFDQFISSGEAKWLRQTGLVMLL 764
Query: 778 PHGYDGQGPEHSSGRLERFLQLGNEDPRYFPS-EEKLQRQHQDCNFQIVYPTTPANLFHI 836
PHGYDGQGPEHSS RLER+LQ+ +++P P E +++Q Q+CN+QIV TTPAN FH+
Sbjct: 765 PHGYDGQGPEHSSARLERYLQMSDDNPYVIPDMEPTMRKQIQECNWQIVNATTPANYFHV 824
Query: 837 LRRQQHRQFRKPLALFFSKQLLRHPLARSNLNEFTE-----------GGFQWIIEDVELG 885
LRRQ HR FRKPL + K LLRH +SNL+EF + F+ +I+D
Sbjct: 825 LRRQIHRDFRKPLIVMAPKNLLRHKDCKSNLSEFDDVQGHPGFDKQGTRFKRLIKDQNDH 884
Query: 886 KSIAPKEEIKRVVLLSGQVYTALHKKRETIQDKNTAFIKIEQLHPFPYAQLRDALNTYPN 945
+ +E I+R+VL SG+VY L +R+ + + A ++EQL PFPY ++ L YP
Sbjct: 885 SDL--EEGIRRLVLCSGKVYYELDDERKKVGATDVAICRVEQLCPFPYDLIQRELKRYP- 941
Query: 946 LEDIVWCQEEPLNMGGWAYAQPRLQTTLKETDKYKDAIIRYAGRNPSGSVAAGSKALHNA 1005
+E +NMG ++Y PRL T ++ ++ I+Y GR PS + A G H
Sbjct: 942 --------KEAMNMGAFSYISPRLWTAMRSVNRGDMEDIKYVGRGPSAATATGFYTFHVK 993
Query: 1006 EEEAFLKEVFGQ 1017
E+ +++ G+
Sbjct: 994 EQAGLVQKAIGK 1005
>7294032 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1001
Score = 852 bits (2202), Expect = 0.0
Identities = 472/1017 (46%), Positives = 647/1017 (63%), Gaps = 57/1017 (5%)
Query: 11 LLHASKFTRIGAVSKPTSLAVFSRGLASGASSTDNFLSTTNASYIDEMYEAWQKDPTSVH 70
LL +S ++ V+ ++ ++ +++ + F + + ASY++EMY AW +DPTSVH
Sbjct: 24 LLKSSSSQQMAKVTAAAAVRTYN------SAAAEPFANGSTASYVEEMYNAWLRDPTSVH 77
Query: 71 VSWDAYFKNMGNLNIPASSAFTAXXXXXXXXXXXXXXQDILIGGSLSGVDQDITT---HL 127
SWDAYF++ ++ P + A GG+++G D T HL
Sbjct: 78 TSWDAYFRSNSYVSPPNLAPVQANTLPLTAFN---------FGGAVAGAAPDSKTIDDHL 128
Query: 128 KVQLLCRAYQVRGHQKAHIDPLQISFGDDKSKPLPRELTLEHYGFTEKDLDRDITLGPGI 187
VQ + R+YQ+RGH AH+DPL+I+ + + + ++ F E+D+DR L
Sbjct: 129 AVQAIIRSYQIRGHNIAHLDPLEINTPELPGNSSTKSI-YANFSFGEQDMDRQFKLPS-- 185
Query: 188 LPRFSRDGRKTMKLREIIAALEKLYCSGYGIEYIHIPSKEQCEWLRERIEIPQPYNYTVD 247
F ++ L+EI+ LE +YC+ G+E++ I S EQC W+R+R E P N++ +
Sbjct: 186 -TTFIGGDEASLPLKEILNRLENVYCNKIGVEFMFINSLEQCNWIRKRFETPGVLNFSPE 244
Query: 248 QKRQILDRLTWATSFETFLSTKFPNDKRFGLEGLEGVVPGIKTLIDRSVELGVEDVVLGM 307
+KR IL RLT AT FE FL+ K+ ++KRFGLEG E ++P +K +ID S ELGVE V++GM
Sbjct: 245 EKRLILARLTRATGFEAFLAKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVIMGM 304
Query: 308 AHRGRLNVLSNVVRKPNESIFSEFKGSVAPEEYEGSGDVKYHLGMNYQRPT-TSGKYVNL 366
HRGRLN L+NV RKP IF++F G A ++ GSGDVKYHLG +R + K + L
Sbjct: 305 PHRGRLNTLANVCRKPLNQIFTQFAGLEAADD--GSGDVKYHLGTYIERLNRVTNKNIRL 362
Query: 367 SLVANPSHLEAADPVVLGRTRAIQFSKNDI-GKYDKAISVLLHGDAAFAAQGIVYETMGF 425
++VANPSHLEA DPVV G+TRA QF + D GK K +S+L+HGDAAF QG+VYETM
Sbjct: 363 AVVANPSHLEAVDPVVQGKTRAEQFYRGDQEGK--KVMSILIHGDAAFCGQGVVYETMHL 420
Query: 426 LHLPAYSTGGTIHVITNNQIGFTTDPRFARSTLYPSDLGKTIDAPIFHVNANDVEALTFI 485
LP Y+T GTIHV+ NNQIGFTTDPRF+RS+ Y +D+ + ++APIFHVNA+D EA+ +
Sbjct: 421 SDLPDYTTHGTIHVVANNQIGFTTDPRFSRSSPYCTDVARVVNAPIFHVNADDPEAVMHV 480
Query: 486 FNLAAEWRATFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYQKISKQKSVIDVYTEKLVS 545
+AAEWRATFH D +ID+VG+R++GHNE D+P FTQPLMYQKI K K+ +D+Y +KL++
Sbjct: 481 CKVAAEWRATFHKDCVIDLVGYRRNGHNEIDEPMFTQPLMYQKIRKHKNCLDLYADKLIA 540
Query: 546 EGSFTKQDIDEHKKWVWGLFEEAYEKAK-DYKPTSREWLTAAWEGFKSPKALATEILSHE 604
EG+ T +++ + EEA+ AK + ++WL + W GF K + L
Sbjct: 541 EGTVTAEEVKSVAAKYENICEEAFALAKTETHVKYKDWLDSPWSGFFEGK----DPLKVA 596
Query: 605 PTVVDADTLKNIGKTISSWPEN---FEVHKNLKRILTNRGKAVESGEGIDWSTGEALAFG 661
PT V +TL +IG SS P N F +HK L R+L R KA+ + DW+ GEA+AFG
Sbjct: 597 PTGVKEETLIHIGNRFSSPPPNAAEFVIHKGLLRVLAAR-KAMVDEKVADWALGEAMAFG 655
Query: 662 SLVLEGNHVRVSGEDVERGTFSQRHAVLHDQKSEN-TYTPLKHLSEKQANFTICNSSLSE 720
SL+ EG HVR+SG+DVERGTFS RH VLH Q + TY L+H+ QA +++ NSSLSE
Sbjct: 656 SLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVDKATYNSLQHMYPDQAPYSVSNSSLSE 715
Query: 721 YGCMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVIIDQFIAAGEVKWKQRSGLVLSLPHG 780
Y +GFE+GYS+TNP+ V+WEAQFGDF+NTAQ IIDQFI++G+ KW ++SGLV+ LPHG
Sbjct: 716 YAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQSIIDQFISSGQSKWVRQSGLVMLLPHG 775
Query: 781 YDGQGPEHSSGRLERFLQLGNEDPRYFP--SEEKLQRQHQDCNFQIVYPTTPANLFHILR 838
+G GPEHSS R+ERFLQ+ ++DP YFP S+E RQ D N+ + +TPAN +HILR
Sbjct: 776 MEGMGPEHSSCRVERFLQMSSDDPDYFPPESDEFGVRQLHDINWIVANCSTPANYYHILR 835
Query: 839 RQQHRQFRKPLALFFSKQLLRHPLARSNLNEFTEGG-FQWIIEDVELGKSIAPKEEIKRV 897
RQ FRKPL L K LLRHP A+S +E +EG FQ II D G + +K+V
Sbjct: 836 RQIALPFRKPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRIIPD--NGPAGQNPSNVKKV 893
Query: 898 VLLSGQVYTALHK-KRETIQDKNTAFIKIEQLHPFPYAQLRDALNTYPNLEDIVWCQEEP 956
V SG+VY L K +RE + A +++EQ+ PFP+ +++ N Y N E +VW QEE
Sbjct: 894 VFCSGRVYYDLTKTRREKQLEGEIAIVRVEQISPFPFDLVKEQANLYKNAE-LVWAQEEH 952
Query: 957 LNMGGWAYAQPRLQTTLKETDKYKDAIIRYAGRNPSGSVAAGSKALHNAEEEAFLKE 1013
N G W Y QPR T L + R+ S A GSKA H E A L +
Sbjct: 953 KNQGSWTYVQPRFLTALNHS------------RDVRASTATGSKAQHIRELNALLND 997
>Hs20541592 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1023
Score = 840 bits (2170), Expect = 0.0
Identities = 470/1030 (45%), Positives = 643/1030 (61%), Gaps = 35/1030 (3%)
Query: 2 LRTIRSSQRLLHASKFTRIGAVSKPTSLAVFSR-GLASGASSTDNFLSTTNASYIDEMYE 60
LRT + R L AS+ + + ++P + F + S + + FLS T+++Y++EMY
Sbjct: 4 LRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYC 63
Query: 61 AWQKDPTSVHVSWDAYFKNMGNLNIPASSAFTAXXXXXXXXXXXXXXQDILIGGSLSGVD 120
AW ++P SVH SWD +F+N N P +A+ + L+ VD
Sbjct: 64 AWLENPKSVHKSWDIFFRNT-NAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQ-PNVD 121
Query: 121 QDITTHLKVQLLCRAYQVRGHQKAHIDPLQISFGD-DKSKP---LPRELTLEHYGFTEKD 176
+ + HL VQ L RAYQ+RGH A +DPL I D D S P + L YG E D
Sbjct: 122 KLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDESD 181
Query: 177 LDRDITLGPGILPRFSRDGRKTMKLREIIAALEKLYCSGYGIEYIHIPSKEQCEWLRERI 236
LD+ L F + LREII LE YC G+E++ I EQC+W+R++
Sbjct: 182 LDKVFHLPT---TTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKF 238
Query: 237 EIPQPYNYTVDQKRQILDRLTWATSFETFLSTKFPNDKRFGLEGLEGVVPGIKTLIDRSV 296
E P +T ++KR +L RL +T FE FL K+ ++KRFGLEG E ++P +KT+ID+S
Sbjct: 239 ETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSS 298
Query: 297 ELGVEDVVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSVAPEEYEGSGDVKYHLGMNYQR 356
E GV+ V++GM HRGRLNVL+NV+RK E IF +F + + EGSGDVKYHLGM ++R
Sbjct: 299 ENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAAD-EGSGDVKYHLGMYHRR 357
Query: 357 PT-TSGKYVNLSLVANPSHLEAADPVVLGRTRAIQFSKNDI-GKYDKAISVLLHGDAAFA 414
+ + + LSLVANPSHLEAADPVV+G+T+A QF D GK K +S+LLHGDAAFA
Sbjct: 358 INRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGK--KVMSILLHGDAAFA 415
Query: 415 AQGIVYETMGFLHLPAYSTGGTIHVITNNQIGFTTDPRFARSTLYPSDLGKTIDAPIFHV 474
QGIVYET LP+Y+T GT+HV+ NNQIGFTTDPR ARS+ YP+D+ + ++APIFHV
Sbjct: 416 GQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV 475
Query: 475 NANDVEALTFIFNLAAEWRATFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYQKISKQKS 534
N++D EA+ ++ +AAEWR+TFH D ++D+V +R++GHNE D+P FTQPLMY++I KQK
Sbjct: 476 NSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKP 535
Query: 535 VIDVYTEKLVSEGSFTKQDIDEHKKWVWGLFEEAYEKAKDYKPTS-REWLTAAWEGFKSP 593
V+ Y E LVS+G + + +E + EEA+ ++KD K + WL + W GF +
Sbjct: 536 VLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTL 595
Query: 594 KALATEILSHEPTVVDADTLKNIGKTISSWP-ENFEVHKNLKRILTNRGKAVESGEGIDW 652
+S T + D L +IG SS P ENF +H L RIL RG+ V++ +DW
Sbjct: 596 DG-QPRSMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKN-RTVDW 653
Query: 653 STGEALAFGSLVLEGNHVRVSGEDVERGTFSQRHAVLHDQK-SENTYTPLKHLSEKQANF 711
+ E +AFGSL+ EG H+R+SG+DVERGTFS RH VLHDQ + T P+ HL QA +
Sbjct: 654 ALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPY 713
Query: 712 TICNSSLSEYGCMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVIIDQFIAAGEVKWKQRS 771
T+CNSSLSEYG +GFE G+++ +P+ V+WEAQFGDF NTAQ IIDQFI G+ KW +++
Sbjct: 714 TVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQN 773
Query: 772 GLVLSLPHGYDGQGPEHSSGRLERFLQLGNEDPRYFPSEEKLQ---RQHQDCNFQIVYPT 828
G+VL LPHG +G GPEHSS R ERFLQ+ N+DP P ++ Q DCN+ +V +
Sbjct: 774 GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCS 833
Query: 829 TPANLFHILRRQQHRQFRKPLALFFSKQLLRHPLARSNLNEFTEG-GFQWIIEDVELGKS 887
TP N FH+LRRQ FRKPL +F K LLRHP ARS+ +E G FQ +I E G +
Sbjct: 834 TPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIP--EDGPA 891
Query: 888 IAPKEEIKRVVLLSGQVYTALHKKRETIQDK--NTAFIKIEQLHPFPYAQLRDALNTYPN 945
E +KR++ +G+VY L ++R+ +D A +IEQL PFP+ L + YPN
Sbjct: 892 AQNPENVKRLLFCTGKVYYDLTRERKA-RDMVGQVAITRIEQLSPFPFDLLLKEVQKYPN 950
Query: 946 LEDIVWCQEEPLNMGGWAYAQPRLQTTLKETDKYKDAIIRYAGRNPSGSVAAGSKALHNA 1005
E + WCQEE N G + Y +PRL+TT+ + YAGR+P+ + A G+K H
Sbjct: 951 AE-LAWCQEEHKNQGYYDYVKPRLRTTISRAKP-----VWYAGRDPAAAPATGNKKTHLT 1004
Query: 1006 EEEAFLKEVF 1015
E + L F
Sbjct: 1005 ELQRLLDTAF 1014
>CE28486 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1029
Score = 837 bits (2162), Expect = 0.0
Identities = 448/997 (44%), Positives = 631/997 (62%), Gaps = 39/997 (3%)
Query: 38 SGASSTDNFLSTTNASYIDEMYEAWQKDPTSVHVSWDAYFKNMGN-------LNIPASSA 90
+ A + FL+ +++ YI++MYEAW +DP+SVH SWDAYF+N+ P ++A
Sbjct: 43 AAAVKHEPFLNGSSSIYIEQMYEAWLQDPSSVHTSWDAYFRNVEAGAGPGQAFQAPPATA 102
Query: 91 FTAXXXXXXXXXXXXXXQDILIGGSLSGVDQDITTHLKVQLLCRAYQVRGHQKAHIDPLQ 150
+ + Q I+ HLK+QLL R+YQ RGH A +DPL
Sbjct: 103 YAGALGVSPAAAQVTTSSAPATRLDTNASVQSISDHLKIQLLIRSYQTRGHNIADLDPLG 162
Query: 151 ISFGDDKSKPLPRELTLEHYGFTEKDLDRDITLGPGILPRFSRDGRKTMKLREIIAALEK 210
I+ D +P EL L YG E+DLDR+ L P +K++ LREI+ L+
Sbjct: 163 INSAD-LDDTIPPELELSFYGLGERDLDREFLLPPTTFI----SEKKSLTLREILQRLKD 217
Query: 211 LYCSGYGIEYIHIPSKEQCEWLRERIEIPQPYNYTVDQKRQILDRLTWATSFETFLSTKF 270
+YC+ G+EY+H+ + EQ +W+R R E P+ + DQK+ + RL +T FE FL+ K+
Sbjct: 218 IYCTSTGVEYMHLNNLEQQDWIRRRFEAPRVTELSHDQKKVLFKRLIRSTKFEEFLAKKW 277
Query: 271 PNDKRFGLEGLEGVVPGIKTLIDRSVELGVEDVVLGMAHRGRLNVLSNVVRKPNESIFSE 330
P++KRFGLEG E ++P +K +ID S LGV+ V+GM HRGRLNVL+NV R+P +I S+
Sbjct: 278 PSEKRFGLEGCEVLIPAMKQVIDSSSTLGVDSFVIGMPHRGRLNVLANVCRQPLATILSQ 337
Query: 331 FKGSVAPEEYEGSGDVKYHLGMNYQRPTT-SGKYVNLSLVANPSHLEAADPVVLGRTRAI 389
F ++ P + EGSGDVKYHLG+ +R S K V +++VANPSHLEA DPVV+G+ RA
Sbjct: 338 FS-TLEPAD-EGSGDVKYHLGVCIERLNRQSQKNVKIAVVANPSHLEAVDPVVMGKVRAE 395
Query: 390 QFSKNDIGKYDKAISVLLHGDAAFAAQGIVYETMGFLHLPAYSTGGTIHVITNNQIGFTT 449
F D K D+ +++LLHGDAAFA QG+V ET LP+Y+T G IH++ NNQIGFTT
Sbjct: 396 AFYAGD-EKCDRTMAILLHGDAAFAGQGVVLETFNLDDLPSYTTHGAIHIVVNNQIGFTT 454
Query: 450 DPRFARSTLYPSDLGKTIDAPIFHVNANDVEALTFIFNLAAEWRATFHTDAIIDVVGWRK 509
DPR +RS+ Y +D+G+ + PIFHVN +D EA+ + N+AA+WR TF D I+D+V +R+
Sbjct: 455 DPRSSRSSPYCTDVGRVVGCPIFHVNVDDPEAVMHVCNVAADWRKTFKKDVIVDLVCYRR 514
Query: 510 HGHNETDQPSFTQPLMYQKISKQKSVIDVYTEKLVSEGSFTKQDIDEHKKWVWGLFEEAY 569
HGHNE D+P FTQPLMYQ+I + K+ ++ Y EK+++EG +Q + E + E+AY
Sbjct: 515 HGHNELDEPMFTQPLMYQRIKQTKTALEKYQEKILNEGVANEQYVKEELTKYGSILEDAY 574
Query: 570 EKA-KDYKPTSREWLTAAWEGFKSPKALATEILSHEPTVVDADTLKNIGKTISSWPENFE 628
E A K +R+WL + W+ F + + L T ++ + ++ I S +PE F
Sbjct: 575 ENAQKVTYVRNRDWLDSPWDDFFKKR----DPLKLPSTGIEQENIEQIIGKFSQYPEGFN 630
Query: 629 VHKNLKRILTNRGKAVESGEGIDWSTGEALAFGSLVLEGNHVRVSGEDVERGTFSQRHAV 688
+H+ L+R L R + ++ +DW+ GEALAFGSL+ EG HVR+SG+DV+RGTFS RH V
Sbjct: 631 LHRGLERTLKGRQQMLKD-NSLDWACGEALAFGSLLKEGIHVRLSGQDVQRGTFSHRHHV 689
Query: 689 LHDQK-SENTYTPLKHLSEKQANFTICNSSLSEYGCMGFEYGYSLTNPDYFVVWEAQFGD 747
LHDQK + Y PL LSE Q +T+CNSSLSEY +GFE GYS+ +P+ V+WEAQFGD
Sbjct: 690 LHDQKVDQKIYNPLNDLSEGQGEYTVCNSSLSEYAVLGFELGYSMVDPNSLVIWEAQFGD 749
Query: 748 FANTAQVIIDQFIAAGEVKWKQRSGLVLSLPHGYDGQGPEHSSGRLERFLQLGNEDPRY- 806
F+NTAQ IIDQFI++G+ KW ++SGLV+ LPHGY+G GPEHSS R ERFLQ+ NED
Sbjct: 750 FSNTAQCIIDQFISSGQSKWIRQSGLVMLLPHGYEGMGPEHSSARPERFLQMCNEDDEID 809
Query: 807 -----FPSEEKLQRQHQDCNFQIVYPTTPANLFHILRRQQHRQFRKPLALFFSKQLLRHP 861
F + Q+ H D N+ + TTPAN++H+LRRQ FRKP +F K LLRHP
Sbjct: 810 LEKIAFEGTFEAQQLH-DTNWIVANCTTPANIYHLLRRQVTMPFRKPAVVFSPKSLLRHP 868
Query: 862 LARSNLNEFTEG-GFQWIIEDVELGKSIAPKEEIKRVVLLSGQVYTALHKKRETI-QDKN 919
+ARS + +F G FQ +I E G ++KRVV +G+VY + R+ + ++ +
Sbjct: 869 MARSPVEDFQSGSNFQRVIP--ETGAPSQNPPDVKRVVFCTGKVYYDMVAARKHVGKEND 926
Query: 920 TAFIKIEQLHPFPYAQLRDALNTYPNLEDIVWCQEEPLNMGGWAYAQPRLQTTLKETDKY 979
A +++EQL PFPY ++ Y E I+W QEE NMG W++ QPR+ + L +
Sbjct: 927 VALVRVEQLSPFPYDLVQQECRKYQGAE-ILWAQEEHKNMGAWSFVQPRINSLLSIDGR- 984
Query: 980 KDAIIRYAGRNPSGSVAAGSKALHNAEEEAFLKEVFG 1016
+YAGR PS S A G+K H E++ + +VFG
Sbjct: 985 ---ATKYAGRLPSSSPATGNKFTHMQEQKEMMSKVFG 1018
>Hs4505493 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1002
Score = 836 bits (2160), Expect = 0.0
Identities = 468/1018 (45%), Positives = 637/1018 (61%), Gaps = 35/1018 (3%)
Query: 2 LRTIRSSQRLLHASKFTRIGAVSKPTSLAVFSR-GLASGASSTDNFLSTTNASYIDEMYE 60
LRT + R L AS+ + + ++P + F + S + + FLS T+++Y++EMY
Sbjct: 4 LRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYC 63
Query: 61 AWQKDPTSVHVSWDAYFKNMGNLNIPASSAFTAXXXXXXXXXXXXXXQDILIGGSLSGVD 120
AW ++P SVH SWD +F+N N P +A+ + L+ VD
Sbjct: 64 AWLENPKSVHKSWDIFFRNT-NAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQ-PNVD 121
Query: 121 QDITTHLKVQLLCRAYQVRGHQKAHIDPLQISFGD-DKSKP---LPRELTLEHYGFTEKD 176
+ + HL VQ L RAYQ+RGH A +DPL I D D S P + L YG E D
Sbjct: 122 KLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDESD 181
Query: 177 LDRDITLGPGILPRFSRDGRKTMKLREIIAALEKLYCSGYGIEYIHIPSKEQCEWLRERI 236
LD+ L F + LREII LE YC G+E++ I EQC+W+R++
Sbjct: 182 LDKVFHLPT---TTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKF 238
Query: 237 EIPQPYNYTVDQKRQILDRLTWATSFETFLSTKFPNDKRFGLEGLEGVVPGIKTLIDRSV 296
E P +T ++KR +L RL +T FE FL K+ ++KRFGLEG E ++P +KT+ID+S
Sbjct: 239 ETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSS 298
Query: 297 ELGVEDVVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSVAPEEYEGSGDVKYHLGMNYQR 356
E GV+ V++GM HRGRLNVL+NV+RK E IF +F + + EGSGDVKYHLGM ++R
Sbjct: 299 ENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAAD-EGSGDVKYHLGMYHRR 357
Query: 357 PT-TSGKYVNLSLVANPSHLEAADPVVLGRTRAIQFSKNDI-GKYDKAISVLLHGDAAFA 414
+ + + LSLVANPSHLEAADPVV+G+T+A QF D GK K +S+LLHGDAAFA
Sbjct: 358 INRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGK--KVMSILLHGDAAFA 415
Query: 415 AQGIVYETMGFLHLPAYSTGGTIHVITNNQIGFTTDPRFARSTLYPSDLGKTIDAPIFHV 474
QGIVYET LP+Y+T GT+HV+ NNQIGFTTDPR ARS+ YP+D+ + ++APIFHV
Sbjct: 416 GQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV 475
Query: 475 NANDVEALTFIFNLAAEWRATFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYQKISKQKS 534
N++D EA+ ++ +AAEWR+TFH D ++D+V +R++GHNE D+P FTQPLMY++I KQK
Sbjct: 476 NSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKP 535
Query: 535 VIDVYTEKLVSEGSFTKQDIDEHKKWVWGLFEEAYEKAKDYKPTS-REWLTAAWEGFKSP 593
V+ Y E LVS+G + + +E + EEA+ ++KD K + WL + W GF +
Sbjct: 536 VLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTL 595
Query: 594 KALATEILSHEPTVVDADTLKNIGKTISSWP-ENFEVHKNLKRILTNRGKAVESGEGIDW 652
+S T + D L +IG SS P ENF +H L RIL RG+ V++ +DW
Sbjct: 596 DG-QPRSMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKN-RTVDW 653
Query: 653 STGEALAFGSLVLEGNHVRVSGEDVERGTFSQRHAVLHDQK-SENTYTPLKHLSEKQANF 711
+ E +AFGSL+ EG H+R+SG+DVERGTFS RH VLHDQ + T P+ HL QA +
Sbjct: 654 ALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPY 713
Query: 712 TICNSSLSEYGCMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVIIDQFIAAGEVKWKQRS 771
T+CNSSLSEYG +GFE G + +P+ V+WEAQFGDF NTAQ IIDQFI G+ KW +++
Sbjct: 714 TVCNSSLSEYGVLGFEAGLRMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQN 773
Query: 772 GLVLSLPHGYDGQGPEHSSGRLERFLQLGNEDPRYFPSEEKLQ---RQHQDCNFQIVYPT 828
G+VL LPHG +G GPEHSS R ERFLQ+ N+DP P ++ Q DCN+ +V +
Sbjct: 774 GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCS 833
Query: 829 TPANLFHILRRQQHRQFRKPLALFFSKQLLRHPLARSNLNEFTEG-GFQWIIEDVELGKS 887
TP N FH+LRRQ FRKPL +F K LLRHP ARS+ +E G FQ +I E G +
Sbjct: 834 TPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIP--EDGPA 891
Query: 888 IAPKEEIKRVVLLSGQVYTALHKKRETIQDK--NTAFIKIEQLHPFPYAQLRDALNTYPN 945
E +KR++ +G+VY L ++R+ +D A +IEQL PFP+ L + YPN
Sbjct: 892 AQNPENVKRLLFCTGKVYYDLTRERKA-RDMVGQVAITRIEQLSPFPFDLLLKEVQKYPN 950
Query: 946 LEDIVWCQEEPLNMGGWAYAQPRLQTTLKETDKYKDAIIRYAGRNPSGSVAAGSKALH 1003
E + WCQEE N G + Y +PRL+TT+ + YAGRNP+ + A G+K H
Sbjct: 951 AE-LAWCQEEHKNQGYYDYVKPRLRTTISRAKP-----VWYAGRNPAAAPATGNKKTH 1002
>Hs8922716 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1010
Score = 808 bits (2086), Expect = 0.0
Identities = 445/983 (45%), Positives = 617/983 (62%), Gaps = 50/983 (5%)
Query: 52 ASYIDEMYEAWQKDPTSVHVSWDAYFKNMGNLNIPASSAFTAXXXXXXXXXXXXXXQDIL 111
+SY++EMY AW ++P SVH SWD++F+ + AF+ +
Sbjct: 49 SSYMEEMYFAWLENPQSVHKSWDSFFREA------SEEAFSGSAQPRPPSVVHEGRSAVS 102
Query: 112 IGGSLSGVDQDITTHLKVQLLCRAYQVRGHQKAHIDPLQISFGDDKSKPLPRELT----- 166
S + +D HL VQ L RAYQ+RGH A +DPL I D S +P +L
Sbjct: 103 SRTKTSKLVED---HLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSF-VPSDLITTIDK 158
Query: 167 LEHYGFTEKDLDRDITLGPGILPRFSRDGRKTMKLREIIAALEKLYCSGYGIEYIHIPSK 226
L Y E DLD++ L F T+ LREII LE YC G+E++ I
Sbjct: 159 LAFYDLQEADLDKEFQLPT---TTFIGGSENTLSLREIIRRLENTYCQHIGLEFMFINDV 215
Query: 227 EQCEWLRERIEIPQPYNYTVDQKRQILDRLTWATSFETFLSTKFPNDKRFGLEGLEGVVP 286
EQC+W+R++ E P ++ ++KR +L RL + FE FL+ K+ ++KRFGLEG E ++P
Sbjct: 216 EQCQWIRQKFETPGVMQFSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIP 275
Query: 287 GIKTLIDRSVELGVEDVVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSVAPEEYEGSGDV 346
+KT+ID+S E+G+E+V+LGM HRGRLNVL+NV+RK E IF F + + EGSGDV
Sbjct: 276 ALKTIIDKSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCRFDPKLEAAD-EGSGDV 334
Query: 347 KYHLGMNYQRPT-TSGKYVNLSLVANPSHLEAADPVVLGRTRAIQFSKNDI-GKYDKAIS 404
KYHLGM ++R + + + LSLVANPSHLEA DPVV G+T+A QF + D GK K +S
Sbjct: 335 KYHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGK--KVMS 392
Query: 405 VLLHGDAAFAAQGIVYETMGFLHLPAYSTGGTIHVITNNQIGFTTDPRFARSTLYPSDLG 464
+L+HGDAAFA QG+VYET LP+Y+T GT+HV+ NNQIGFTTDPR ARS+ YP+D+
Sbjct: 393 ILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVA 452
Query: 465 KTIDAPIFHVNANDVEALTFIFNLAAEWRATFHTDAIIDVVGWRKHGHNETDQPSFTQPL 524
+ ++APIFHVNA+D EA+ ++ ++AAEWR TF+ D ++D+V +R+ GHNE D+P FTQPL
Sbjct: 453 RVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPL 512
Query: 525 MYQKISKQKSVIDVYTEKLVSEGSFTKQDIDEHKKWVWGLFEEAYEKAKDYKPTS-REWL 583
MY++I +Q V+ Y +KL++EG+ T Q+ +E + EEAY ++KD K + WL
Sbjct: 513 MYKQIHRQVPVLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWL 572
Query: 584 TAAWEGF----KSPKALATEILSHEPTVVDADTLKNIGKTISSWP-ENFEVHKNLKRILT 638
+ W GF PK++ T + D L +IG SS P E+F++H L RIL
Sbjct: 573 DSPWPGFFNVDGEPKSMTC-----PATGIPEDMLTHIGSVASSVPLEDFKIHTGLSRIL- 626
Query: 639 NRGKA-VESGEGIDWSTGEALAFGSLVLEGNHVRVSGEDVERGTFSQRHAVLHDQK-SEN 696
RG+A + +DW+ E +AFGSL+ EG HVR+SG+DVERGTFS RH VLHDQ+
Sbjct: 627 -RGRADMTKNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRR 685
Query: 697 TYTPLKHLSEKQANFTICNSSLSEYGCMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVII 756
T P+ HL QA +T+CNSSLSEYG +GFE GY++ +P+ V+WEAQFGDF NTAQ II
Sbjct: 686 TCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCII 745
Query: 757 DQFIAAGEVKWKQRSGLVLSLPHGYDGQGPEHSSGRLERFLQLGNEDPRYFPSEEK--LQ 814
DQFI+ G+ KW + +G+VL LPHG +G GPEHSS R ERFLQ+ N+D +P+ K
Sbjct: 746 DQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPAFTKDFEV 805
Query: 815 RQHQDCNFQIVYPTTPANLFHILRRQQHRQFRKPLALFFSKQLLRHPLARSNLNEFTEG- 873
Q DCN+ +V +TPAN FH+LRRQ FRKPL +F K LLRHP A+S+ ++ G
Sbjct: 806 SQLYDCNWIVVNCSTPANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGT 865
Query: 874 GFQWIIEDVELGKSIAPKEEIKRVVLLSGQVYTALHKKRETIQ-DKNTAFIKIEQLHPFP 932
FQ +I E G + E+++R++ +G+VY L K+R + ++ A ++EQ+ PFP
Sbjct: 866 SFQRVIP--EDGAAARAPEQVQRLIFCTGKVYYDLVKERSSQDLEEKVAITRLEQISPFP 923
Query: 933 YAQLRDALNTYPNLEDIVWCQEEPLNMGGWAYAQPRLQTTLKETDKYKDAIIRYAGRNPS 992
+ ++ YP E + WCQEE NMG + Y PR T L+ I Y GR+P+
Sbjct: 924 FDLIKQEAEKYPGAE-LAWCQEEHKNMGYYDYISPRFMTILRRARP-----IWYVGRDPA 977
Query: 993 GSVAAGSKALHNAEEEAFLKEVF 1015
+ A G++ H + FL F
Sbjct: 978 AAPATGNRNTHLVSLKKFLDTAF 1000
>7292108 [G] KOG0450 2-oxoglutarate dehydrogenase E1 subunit
Length = 1075
Score = 745 bits (1924), Expect = 0.0
Identities = 413/989 (41%), Positives = 589/989 (58%), Gaps = 43/989 (4%)
Query: 39 GASSTDNFLSTTNASYIDEMYEAWQKDPTSVHVSWDAYFKN-------MGNLNIPASSAF 91
G D+F + +A+YI+ +Y W+++P+SV SW+ F + L + S +
Sbjct: 44 GVHDLDSFANGCSAAYIEGLYNKWKRNPSSVDESWNELFSSNDWSSPKRSPLQVSHSRKY 103
Query: 92 TAXXXXXXXXXXXXXXQDILIGGSLSGVD-----QDITTHLKVQLLCRAYQVRGHQKAHI 146
+ G S + ++I H +Q + RAYQ RGH A +
Sbjct: 104 RRPPVERIAVKARSGERTASGGASAAPAAPPSDWKNIDDHHVIQAIIRAYQSRGHLAADL 163
Query: 147 DPLQI------SFGDDKSKPLPRELTLEHYGFTEKDLDRDITLGPGILPRFSRDGRKTMK 200
DPL I + D + RE+ +H+ + DL+ L + ++ +
Sbjct: 164 DPLGIVGPKKRTSVDGTQRHAAREVLRQHFSYIFNDLNTVFKLPSSTM---IGGDQEFLS 220
Query: 201 LREIIAALEKLYCSGYGIEYIHIPSKEQCEWLRERIEIPQPYNYTVDQKRQILDRLTWAT 260
L+EI+ LE++YC G+EY+ I S + WLR+R E P + T ++K+ IL+RLT +T
Sbjct: 221 LKEILDRLERIYCGHIGVEYMQITSLTKTNWLRDRFEKPGGLDLTKEEKKLILERLTRST 280
Query: 261 SFETFLSTKFPNDKRFGLEGLEGVVPGIKTLIDRSVELGVEDVVLGMAHRGRLNVLSNVV 320
FE FL+ KF ++KRFGLEG + ++P IK ++DR+ + GVE +++GMAHRGRLNVL+N+
Sbjct: 281 GFENFLAKKFSSEKRFGLEGCDIMIPAIKEVVDRATDHGVESILIGMAHRGRLNVLANIC 340
Query: 321 RKPNESIFSEFKGSVAPEEYEGSGDVKYHLGMNYQRPTT-SGKYVNLSLVANPSHLEAAD 379
RKP I S+F G A + GSGDVKYHLG+ +R + + V +++VANPSHLE +
Sbjct: 341 RKPISDILSQFHGLQATDS--GSGDVKYHLGVFQERLNRQTNRMVRITVVANPSHLEHVN 398
Query: 380 PVVLGRTRAIQFSKNDIGKYDKAISVLLHGDAAFAAQGIVYETMGFLHLPAYSTGGTIHV 439
PV+LG+ RA F + D + +++HGDA+F+ QG+VYE+M LP Y+T GTIH+
Sbjct: 399 PVLLGKARAEMFQRGDTCG-STVMPIIIHGDASFSGQGVVYESMHLSDLPNYTTYGTIHI 457
Query: 440 ITNNQIGFTTDPRFARSTLYPSDLGKTIDAPIFHVNANDVEALTFIFNLAAEWRATFHTD 499
++NNQ+GFTTDPRF+RS+ Y +D+ K ++API HVNA+D EA +A ++R F D
Sbjct: 458 VSNNQVGFTTDPRFSRSSRYCTDVAKVVNAPILHVNADDPEACIQCARIAIDYRTRFKKD 517
Query: 500 AIIDVVGWRKHGHNETDQPSFTQPLMYQKISKQKSVIDVYTEKLVSEGSFTKQDIDEHKK 559
+ID+VG+R++GHNE D+P FTQPLMYQ+I K K + +Y +KL+ EG T +
Sbjct: 518 VVIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKPCLQLYADKLIKEGVVTDSEFKAMVS 577
Query: 560 WVWGLFEEAYEKAKDYKPTS-REWLTAAWEGFKSPKALATEILSHEPTVVDADTLKNIGK 618
+ E+A+ K+K K W+ + W GF + + L PT + DTLK IG
Sbjct: 578 SYEKICEDAWAKSKTIKTIKYSSWIDSPWPGFFEGR----DRLKLCPTGISTDTLKTIGN 633
Query: 619 TISSWP---ENFEVHKNLKRILTNRGKAVESGEGIDWSTGEALAFGSLVLEGNHVRVSGE 675
S+ P FE HK + RIL R + V+ + DWS GEA AFGSL+ EG HVR+SG+
Sbjct: 634 MFSTPPPPEHKFETHKGILRILAQRTQMVQD-KVADWSLGEAFAFGSLLKEGIHVRLSGQ 692
Query: 676 DVERGTFSQRHAVLHDQKSEN-TYTPLKHLSEKQANFTICNSSLSEYGCMGFEYGYSLTN 734
DVERGTFS RH VLH Q + Y L HL QA +++ NSSLSE +GFE+GYS+ +
Sbjct: 693 DVERGTFSHRHHVLHHQSEDKVVYNSLDHLYPDQAPYSVSNSSLSECAVLGFEHGYSMAS 752
Query: 735 PDYFVVWEAQFGDFANTAQVIIDQFIAAGEVKWKQRSGLVLSLPHGYDGQGPEHSSGRLE 794
P+ V+WE QFGDF NTAQ IID FIA+GE KW ++SG+V+ LPH +G GPEHSSGR+E
Sbjct: 753 PNALVMWEGQFGDFCNTAQCIIDTFIASGETKWVRQSGVVMLLPHSMEGMGPEHSSGRIE 812
Query: 795 RFLQLGNEDPRYFP---SEEKLQRQHQDCNFQIVYPTTPANLFHILRRQQHRQFRKPLAL 851
RFLQ+ ++DP +P + + RQ + N+ + +TPANLFH LRRQ FRKPL
Sbjct: 813 RFLQMSDDDPDVYPDTCDADFVARQLMNVNWIVTNLSTPANLFHCLRRQVKMGFRKPLIN 872
Query: 852 FFSKQLLRHPLARSNLNEFTE-GGFQWIIEDVELGKSIAPKEEIKRVVLLSGQVYTALHK 910
F K LLRHPLARS +F E FQ II D G + + ++++V SG+VY L K
Sbjct: 873 FSPKSLLRHPLARSPFKDFNECSCFQRIIPD--KGPAGKQPDCVQKLVFCSGKVYYDLVK 930
Query: 911 KRETIQDKNT-AFIKIEQLHPFPYAQLRDALNTYPNLEDIVWCQEEPLNMGGWAYAQPRL 969
+R+ + T A +++EQL PFPY + L YP E ++W QEE NMG W+Y QPR
Sbjct: 931 ERDDHEQVETVALVRVEQLCPFPYDLISQQLELYPKAE-LLWAQEEHKNMGAWSYVQPRF 989
Query: 970 QTTLKETDKYKDAIIRYAGRNPSGSVAAG 998
T L + + I G + + + G
Sbjct: 990 DTALLKNENESSVSIGVGGASSADAFPTG 1018
>Hs18375678 [G] KOG0451 Predicted 2-oxoglutarate dehydrogenase E1 subunit
Length = 919
Score = 566 bits (1459), Expect = e-161
Identities = 321/836 (38%), Positives = 484/836 (57%), Gaps = 41/836 (4%)
Query: 195 GRKTMKLREIIAALEKLYCSGYGIEYIHIPSKEQCEWLRERIEIPQPYNYTVDQKRQILD 254
G++ L E++ L ++YC IE + S+++ +W +R E Q +T ++++ +
Sbjct: 109 GKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSK 168
Query: 255 RLTWATSFETFLSTKFPNDKRFGLEGLEGVVPGIKTLIDRSVELGVEDVVLGMAHRGRLN 314
+ + F+ FL+TKF KR+G EG E ++ L+ S G+ DV++GM HRGRLN
Sbjct: 169 LMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGRLN 228
Query: 315 VLSNVVRKPNESIFSEFKG-SVAPEEYEGSGDVKYHLGMNYQRPTTSGKYVNLSLVANPS 373
+L+ +++ P E +F + +G S PE + +GDV HL + + ++++++ NPS
Sbjct: 229 LLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPS 288
Query: 374 HLEAADPVVLGRTRAIQFSKNDIGKY---------DKAISVLLHGDAAFAAQGIVYETMG 424
HLEA +PV +G+TR Q S+ D G Y D+ I + +HGDA+F QGIV ET
Sbjct: 289 HLEAVNPVAVGKTRGRQQSRQD-GDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFT 347
Query: 425 FLHLPAYSTGGTIHVITNNQIGFTTDPRFARSTLYPSDLGKTIDAPIFHVNANDVEALTF 484
+LP + GG++H+I NNQ+G+TT RS+LY SD+GK + I HVN + E +
Sbjct: 348 LSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVR 407
Query: 485 IFNLAAEWRATFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYQKISKQKSVIDVYTEKLV 544
LA E++ F D IID++ +R+ GHNE D+P +T P+MY+ I +KS+ D Y E L+
Sbjct: 408 ATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLI 467
Query: 545 SEGSFTKQDIDEHKKWVWGLFEEAYEKAKDYKPTSREWLTAAWEGFKSPKALATEILSHE 604
+ G T++++ E K + + Y+P + L A W+G P+A T
Sbjct: 468 AGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALN-LQAHWQGLAQPEAQITT----W 522
Query: 605 PTVVDADTLKNIGKTISSWPENFEVHKN-LKRILTNRGKAVESGEGIDWSTGEALAFGSL 663
T V D L+ +G P ++H + LK + +R + + G +DW+T EALA GSL
Sbjct: 523 STGVPLDLLRFVGMKSVEVPRELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSL 582
Query: 664 VLEGNHVRVSGEDVERGTFSQRHAVLHDQKSENTYTPLKHLSEKQANF-TICNSSLSEYG 722
+ +G +VR+SG+DV RGTFSQRHA++ Q++++TY PL H+ Q F + NS LSE
Sbjct: 583 LAQGFNVRLSGQDVGRGTFSQRHAMVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEA 642
Query: 723 CMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVIIDQFIAAGEVKWKQRSGLVLSLPHGYD 782
+GFEYG S+ +P +WEAQFGDF N AQ+I D FI+ GE KW +SG+V+ LPHGYD
Sbjct: 643 VLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYD 702
Query: 783 GQGPEHSSGRLERFLQLGNEDPRYFPSEEKLQRQHQDCNFQIVYPTTPANLFHILRRQQH 842
G GP+HSS R+ERFLQ+ + +EE + N +V+PTTPA FH+LRRQ
Sbjct: 703 GAGPDHSSCRIERFLQMCDS------AEEGV--DGDTVNMFVVHPTTPAQYFHLLRRQMV 754
Query: 843 RQFRKPLALFFSKQLLRHPLARSNLNEFTEG-GFQWIIEDVELGKSIAPKEEIKRVVLLS 901
R FRKPL + K LLR P A S L E G F +I D S+ PK ++K +V S
Sbjct: 755 RNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGD----SSVDPK-KVKTLVFCS 809
Query: 902 GQVYTALHKKRETIQDK--NTAFIKIEQLHPFPYAQLRDALNTYPNLEDIVWCQEEPLNM 959
G+ + +L K+RE++ K + A I++E+L PFP L+ ++ Y +++D +W QEEP NM
Sbjct: 810 GKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSKYKHVKDHIWSQEEPQNM 869
Query: 960 GGWAYAQPRLQTTLKETDKYKDAIIRYAGRNPSGSVAAGSKALHNAEEEAFLKEVF 1015
G W++ PR + L +R GR P A G +H + E L + F
Sbjct: 870 GPWSFVSPRFEKQLA-------CKLRLVGRPPLPVPAVGIGTVHLHQHEDILAKTF 918
>CE23468 [G] KOG0451 Predicted 2-oxoglutarate dehydrogenase E1 subunit
Length = 906
Score = 559 bits (1441), Expect = e-159
Identities = 323/871 (37%), Positives = 490/871 (56%), Gaps = 50/871 (5%)
Query: 170 YGFTEKDLD----RDIT----LGPGILP-RFSRDGRKTMKLREIIAALEKLYCSGYGIEY 220
YG+ E DLD R + L P I + + L ++ L +YC IE+
Sbjct: 60 YGYLEADLDPLGLRKVESVAELDPAIYGLSLDENVKGNFSLHDLAEQLRHIYCGPTAIEF 119
Query: 221 IHIPSKEQCEWLRERIEIPQPYNYTVDQKRQILDRLTWATSFETFLSTKFPNDKRFGLEG 280
+HI + E+ +W+ + E ++ +I D + +F+ FLSTKFP KR+G EG
Sbjct: 120 MHINNWEERQWISQNFENCIAEELRKEELLRIGDLMLKCENFDKFLSTKFPTLKRYGAEG 179
Query: 281 LEGVVPGIKTLIDRSVELGVEDVVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSVA-PEE 339
E + L + + E VE++++G+AHRGRLN+L+ ++ P +F + KG PE
Sbjct: 180 AESMFAFFSELFEGAAEKQVEEIIIGIAHRGRLNLLTQLMDFPPVHMFRKIKGRAEFPES 239
Query: 340 YEGSGDVKYHLGMNYQRPTTSGKYVNLSLVANPSHLEAADPVVLGRTRAIQFSKNDIGKY 399
+ +GDV HL ++ + G V+++++ NPSHLEA +PV +G+ RA +S N G Y
Sbjct: 240 ADAAGDVLSHLVSSFDYKGSEGN-VHVTMLPNPSHLEAVNPVAMGKARARAWSMNK-GDY 297
Query: 400 ----------DKAISVLLHGDAAFAAQGIVYETMGFLHLPAYSTGGTIHVITNNQIGFTT 449
D ++VL+HGD AF QG+V+E++ P + GGT+H++TNNQI FT
Sbjct: 298 SPDERSARAGDSVLNVLVHGDGAFTGQGVVWESIALSQAPHFRLGGTVHLVTNNQIAFTA 357
Query: 450 DPRFARSTLYPSDLGKTIDAPIFHVNANDVEALTFIFNLAAEWRATFHTDAIIDVVGWRK 509
+ RS+ + +D+ K + P+ HVN + E + LA +R F D I++V +R+
Sbjct: 358 ESSVGRSSTHCTDIAKAFEYPVIHVNGDHPEEVVKATRLALAYRERFRKDVFINLVCFRR 417
Query: 510 HGHNETDQPSFTQPLMYQKISKQKSVIDVYTEKLVSEGSFTKQDIDEHKKWVWGLFEEAY 569
GHNE D P+FT P+MY+++ ++SV ++ ++LV EG T++ + E +
Sbjct: 418 WGHNELDDPTFTSPVMYKEVEARESVPRLFLDRLVEEGFTTEEAVKEQLQKHTEQLNNEL 477
Query: 570 EKAKDYKPTSREWLTAAWEGFK-SPKALATEILSHEPTVVDADTLKNIGKTISSWPENFE 628
+K P WEGFK +PKA+ + T V D L+ IG PE+F+
Sbjct: 478 KKVDSTVPIDISH-RGRWEGFKQAPKAIES-----WDTGVATDLLRFIGAGSVKVPEDFD 531
Query: 629 VHKNL-KRILTNRGKAVESGEGIDWSTGEALAFGSLVLEGNHVRVSGEDVERGTFSQRHA 687
HK+L K + +R + +++GEGIDW+T EA+AFGS++LEGN VR+SG+DV RGTF RHA
Sbjct: 532 THKHLYKMHIDSRMQKMQTGEGIDWATAEAMAFGSILLEGNDVRISGQDVGRGTFCHRHA 591
Query: 688 VLHDQKSENTYTPLKHLSEKQAN-FTICNSSLSEYGCMGFEYGYSLTNPDYFVVWEAQFG 746
++ DQ +++ + PL L E+Q N + N+ LSE +GFE+G+S NP +WEAQFG
Sbjct: 592 MMVDQSTDHIHIPLNELVEEQKNQLEVANNLLSEEAILGFEWGFSSENPRRLCIWEAQFG 651
Query: 747 DFANTAQVIIDQFIAAGEVKWKQRSGLVLSLPHGYDGQGPEHSSGRLERFLQLGNEDPRY 806
DF N AQ+IID F+A+ E KW SGL + LPHG+DG GPEHSS R+ERFLQL +
Sbjct: 652 DFFNGAQIIIDTFLASAESKWLTSSGLTMLLPHGFDGAGPEHSSCRMERFLQLCDS---- 707
Query: 807 FPSEEKLQRQHQDCNFQIVYPTTPANLFHILRRQQHRQFRKPLALFFSKQLLRHPLARSN 866
E++ ++ N ++ PTT A FH+LRRQ +RKPL + K LLRHP A S
Sbjct: 708 --REDQTPVDGENVNMRVANPTTSAQYFHLLRRQVVPNYRKPLIVVGPKILLRHPKAAST 765
Query: 867 LNEFTEG-GFQWIIEDVELGKSIAPKEEIKRVVLLSGQVYTALHKKRETIQDKNT-AFIK 924
+NEF G +Q +I + S ++IK+V+ +SG+ + + K R+ K++ A ++
Sbjct: 766 INEFGPGTTYQNVISEEHATSS----QKIKKVIFVSGKHWINVEKARDERGLKDSVAIVR 821
Query: 925 IEQLHPFPYAQLRDALNTYPNLEDIVWCQEEPLNMGGWAYAQPRLQTTLKETDKYKDAII 984
+E L PFP L+ L YP +D VW QEEP N G W++ +PR + L +
Sbjct: 822 VEMLCPFPVVDLQAVLKKYPGAQDFVWSQEEPRNAGAWSFVRPRFENAL-------GVRL 874
Query: 985 RYAGRNPSGSVAAGSKALHNAEEEAFLKEVF 1015
++AGR A H E E + + F
Sbjct: 875 KFAGRPELAWTATAIGEHHTKEAEEVINQTF 905
>7302023 [G] KOG0451 Predicted 2-oxoglutarate dehydrogenase E1 subunit
Length = 901
Score = 508 bits (1308), Expect = e-143
Identities = 320/893 (35%), Positives = 488/893 (53%), Gaps = 67/893 (7%)
Query: 135 AYQVRGHQKAHIDPLQISFGDDKSKPLPRELTLEHYGFTEKDLDRDITLGPGILPRFSRD 194
A++ GH+ A ++P+ I + + EL+ YG ++ R L G P+ + +
Sbjct: 62 AFRQHGHKLAAVNPISIRTSQQELQ----ELSPAFYGLQTQEPVRTDGLLSG--PQVAHN 115
Query: 195 GRKTMKLREIIAALEKLYCS-GYGIEYIHIPSKEQCEWLRERIEIPQPYNYTVDQKRQIL 253
+ +L L+ +YC E+ ++ E+ EWL E ++ +I
Sbjct: 116 VAQLEQL------LKDIYCGRSTSAEFSYVEDIEEREWLARNFETLDQQQLGKSERCEIA 169
Query: 254 DRLTWATSFETFLSTKFPNDKRFGLEGLEGVVPGIKTLIDRSVELGVEDVVLGMAHRGRL 313
+ L + +++ F++ KFP KR+G EG E ++ L+ SV+ +E VVL M HRGR
Sbjct: 170 ELLIKSQAWDNFMALKFPTVKRYGGEGAESMLAFFWQLLRDSVQANIEHVVLAMPHRGRT 229
Query: 314 NVLSNVVRKPNESIFSEFKG-SVAPEEYEGSGDVKYHLGMNYQRPTTSGKYVNLSLVANP 372
+ + ++ +F + G S E+ E DV H ++ Q GK ++ S+V NP
Sbjct: 230 PLQAALLNMRPAKVFRKLSGASEFSEDIEAMSDVISHFHVSEQLKIL-GKKLSFSMVRNP 288
Query: 373 SHLEAADPVVLGRTRAIQFSKNDIGKY--------DKAISVLLHGDAAFAAQGIVYETMG 424
SHLEAA+PV +G+TR+ Q ++ + G + + ++V+LHGDAAFA QGI E +
Sbjct: 289 SHLEAANPVAMGKTRSKQQARGE-GAFGDGSQPFGEHVLNVILHGDAAFAGQGINQECLN 347
Query: 425 FLHLPAYSTGGTIHVITNNQIGFTTDPRFARSTLYPSDLGKTIDAPIFHVNANDVEALTF 484
++P + GG++H+I NNQ+GFTT RST Y SDL K+I AP+FHVN +D EAL
Sbjct: 348 MAYVPHFEVGGSLHLIVNNQVGFTTPGDRGRSTAYTSDLAKSIQAPVFHVNGDDPEALAR 407
Query: 485 IFNLAAEWRATFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYQKISKQKSVIDVYTEKLV 544
+ +LA ++ F D ID+ +R+ H P L Q+++K E+++
Sbjct: 408 VTSLAFRYQREFRKDIFIDLNCFRRIVHQRESVPD----LYAQQLAK---------EQVL 454
Query: 545 SEGSFTKQDIDEHKKWVWGLFEEAYEKAKDYKPTSREWLTAAWEGFKSPKALATEILSHE 604
SE S K+ DE+ K++ E A Y+P + W F+ ++ L++
Sbjct: 455 SE-SKAKEMRDEYMKYLG----EELALAPAYQPPP-SYFEKQWTNFQ---LAPSKELTYW 505
Query: 605 PTVVDADTLKNIGKTISSWPENFEVHKNLKRILTN-RGKAVESGEGIDWSTGEALAFGSL 663
T +D L IG+ ++PE+F +H +L + N R K +E+G IDWST EALA GSL
Sbjct: 506 DTGLDYSLLHYIGQQSVTFPEDFNIHPHLLKTHVNARLKKLENGVKIDWSTAEALAIGSL 565
Query: 664 VLEGNHVRVSGEDVERGTFSQRHAVLHDQKSENTYTPLKHLSEKQAN-FTICNSSLSEYG 722
+ +G++VR+SGEDV RGTFS RHA+L DQ++ + PL + + +S LSE
Sbjct: 566 MYQGHNVRISGEDVGRGTFSHRHAMLVDQQTNEMFIPLNSMEGGNGGKLELAHSILSEEA 625
Query: 723 CMGFEYGYSLTNPDYFVVWEAQFGDFANTAQVIIDQFIAAGEVKWKQRSGLVLSLPHGYD 782
+GFEYG ++ NP+ ++WEAQFGDFAN AQ+IID FI +GE KW + + LV+ LPHGYD
Sbjct: 626 VLGFEYGMAIDNPNNLIIWEAQFGDFANGAQIIIDTFIVSGETKWMESNALVMLLPHGYD 685
Query: 783 GQGPEHSSGRLERFLQLGNEDPRYFPSEEKLQRQHQDCNFQIVYPTTPANLFHILRRQQH 842
G EHSS R+ERFLQL + ++ N IV PTTPA +H+LRRQ
Sbjct: 686 GAASEHSSCRIERFLQLCD--------SKETSADGDSVNVHIVNPTTPAQYYHVLRRQLA 737
Query: 843 RQFRKPLALFFSKQLLRHPLARSNLNEFTEGGFQWIIEDVELGKSIAPKEEIKRVVLLSG 902
R FRKPL + K LLR P A S +F G + +V LG +IA E++++V+L SG
Sbjct: 738 RNFRKPLVVVAPKTLLRLPAATSTHEDFQPG---TLFHNV-LGDTIAKPEQVRKVILCSG 793
Query: 903 QVYTALHKKRETIQDKNTAFIKIEQLHPFPYAQLRDALNTYPNLEDIVWCQEEPLNMGGW 962
+ Y L ++RE Q +TA +++E L PFP +L+ L Y N++ VW QEE NMG W
Sbjct: 794 KHYYTLAEEREKRQAYDTAILRLESLCPFPIQELQAQLAQYGNVQSFVWSQEEHRNMGAW 853
Query: 963 AYAQPRLQTTLKETDKYKDAIIRYAGRNPSGSVAAGSKALHNAEEEAFLKEVF 1015
+ +PR + + + + Y GR + + A G +H E + + F
Sbjct: 854 TFVRPRFENLIGQQ-------LHYCGRCEAPTPATGIGKVHKREVDEIVAAPF 899
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,049,663
Number of Sequences: 60738
Number of extensions: 2928416
Number of successful extensions: 6437
Number of sequences better than 1.0e-05: 13
Number of HSP's better than 0.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 6296
Number of HSP's gapped (non-prelim): 17
length of query: 1017
length of database: 30,389,216
effective HSP length: 116
effective length of query: 901
effective length of database: 23,343,608
effective search space: 21032590808
effective search space used: 21032590808
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)