ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI1521 good D KOG2166 Cell cycle control, cell division, chromosome partitioning Cullins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI1521 537921 540356 812
(812 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDL132w [D] KOG2166 Cullins 938 0.0
Hs4503161 [D] KOG2166 Cullins 416 e-115
SPAC17G6.12 [D] KOG2166 Cullins 413 e-115
7304137 [D] KOG2166 Cullins 382 e-105
CE29089 [D] KOG2166 Cullins 357 3e-98
CE11928 [D] KOG2166 Cullins 302 1e-81
Hs19482174 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component 288 2e-77
7302125 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component 253 6e-67
At1g69670 [D] KOG2166 Cullins 246 1e-64
Hs4503165 [D] KOG2166 Cullins 238 3e-62
CE25691 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component 238 4e-62
CE24730 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component 238 4e-62
CE16729 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component 238 4e-62
At1g26830 [D] KOG2166 Cullins 231 4e-60
Hs13270467 [D] KOG2167 Cullins 218 3e-56
Hs11140811 [D] KOG2167 Cullins 206 1e-52
7298217 [D] KOG2166 Cullins 206 2e-52
SPAC24H6.03 [D] KOG2166 Cullins 204 4e-52
At1g43140 [D] KOG2166 Cullins 202 2e-51
7301740 [O] KOG2285 E3 ubiquitin ligase Cullin 1 component 198 3e-50
Hs4503167 [O] KOG2285 E3 ubiquitin ligase Cullin 1 component 191 5e-48
At5g46210 [D] KOG2167 Cullins 188 3e-47
CE27593 [D] KOG2166 Cullins 187 6e-47
At4g02570 [D] KOG2166 Cullins 182 2e-45
At1g02980 [D] KOG2166 Cullins 169 2e-41
7304097 [D] KOG2167 Cullins 164 7e-40
CE06658 [O] KOG2285 E3 ubiquitin ligase Cullin 1 component 162 3e-39
YGR003w [D] KOG2166 Cullins 148 3e-35
SPAC3A11.08 [D] KOG2167 Cullins 144 5e-34
CE24979 [D] KOG2167 Cullins 134 7e-31
7294516 [D] KOG2166 Cullins 118 3e-26
At1g59790 [D] KOG2166 Cullins 86 2e-16
Hs22049312 [D] KOG2166 Cullins 84 7e-16
YJL047c [D] KOG2166 Cullins 68 6e-11
At1g59800 [D] KOG2166 Cullins 51 6e-06
>YDL132w [D] KOG2166 Cullins
Length = 815
Score = 938 bits (2425), Expect = 0.0
Identities = 465/824 (56%), Positives = 607/824 (73%), Gaps = 21/824 (2%)
Query: 1 MADTLPRSDDLEATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCV 60
M++TLPRSDDLEATWNF++PGI+QIL + + RV K+LSP MYMEVYTAIYNYCV
Sbjct: 1 MSETLPRSDDLEATWNFIEPGINQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCV 60
Query: 61 NKSRSTGHFQSDIIGKQMNQSSILVGGEIYENLKNYLKDYISNLKKDDNVTFLNFYVRRW 120
NKSRS+GHF +D + QS+ILVG EIYE LKNYLK+YI N K+ ++ TFL FYV+RW
Sbjct: 61 NKSRSSGHFSTD---SRTGQSTILVGSEIYEKLKNYLKNYILNFKQSNSETFLQFYVKRW 117
Query: 121 ERFTIGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEI 180
+RFTIGAIFLN FDYMNRYWVQKERSDGKRHIFD +TLCLMTWKEVMF+ K L+ E+
Sbjct: 118 KRFTIGAIFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMTWKEVMFDPSKDVLINEL 177
Query: 181 FDQLDLQRRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYT 240
DQ+ L R G+++ +S I+ AIKS V LGIDP DLKKLNLNVYIQ FE+PFL+KT+EYYT
Sbjct: 178 LDQVTLGREGQIIQRSNISTAIKSLVALGIDPQDLKKLNLNVYIQVFEKPFLKKTQEYYT 237
Query: 241 KMSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKK 300
+ +N++L+ HSV+EYI +A+E I EEK M +Y D HT PLS ALN+VLI DH +KL+
Sbjct: 238 QYTNDYLEKHSVTEYIFEAHEIIKREEKAMTIYWDDHTKKPLSMALNKVLITDHIEKLEN 297
Query: 301 EFILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQ 360
EF++LLD +D I +Y L++RD+ ++P + F+ Y+K+ G EI L+ H + +
Sbjct: 298 EFVVLLDARDIEKITSLYALIRRDFTLIPRMASVFENYVKKTGENEISSLLAMHKHNIMK 357
Query: 361 DSNAKRQP-------GLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFIN 413
+ NA + LSP+DY+K L+ V+ +F I E F + AKALD C FIN
Sbjct: 358 NENANPKKLALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFIN 417
Query: 414 NNSFAIPPGSPKFATSRAPEMLAKYSDQLLKKSTKNNEQVDLTVDDIMTVFKFLADKDAF 473
N FA+P GSPK ATS+ EMLAKYSD LLKK+TK D++ +DI+T+FK+L DKDAF
Sbjct: 418 INEFALPAGSPKSATSKTSEMLAKYSDILLKKATKPEVASDMSDEDIITIFKYLTDKDAF 477
Query: 474 EMHYRKNLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFS 533
E HYR+ AKRLIHG+S S DEE IIQRLQ+ NS+EYT KITKM QD++LSK L D+F+
Sbjct: 478 ETHYRRLFAKRLIHGTSTSAEDEENIIQRLQAANSMEYTGKITKMFQDIRLSKILEDDFA 537
Query: 534 TFISQDGNNTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYT 593
+ + + + ++K P+L+P +LA+N+WPFSYQ EF LP L S KL+ Y+
Sbjct: 538 VALKNEPDYS------KAKYPDLQPFVLAENMWPFSYQEVEFKLPKELVPSHEKLKESYS 591
Query: 594 DKHSGRILKWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQER 653
KH+GRILKWLWP+ RGE+KA IGKPG+ PF FTVT+FQMAIL L+ND LT E IQE
Sbjct: 592 QKHNGRILKWLWPLCRGELKADIGKPGRMPFNFTVTLFQMAILLLYNDADVLTLENIQEG 651
Query: 654 TNLKATQIASNMYPFVKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKND 713
T+L IA+ M PF+K KL+ Q P G+++++K +T++ L++PY+ KT++NFA+ VKND
Sbjct: 652 TSLTIQHIAAAMVPFIKFKLIQQVPPGLDALVKPETQFKLSRPYKALKTNINFASGVKND 711
Query: 714 LTFTAT-----VNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLM 768
+ + + +G+ L +E ++ EKELN +R +FL ACIVRIMKAKR LPH++L+
Sbjct: 712 ILQSLSGGGHDNHGNKLGNKRLTEDERIEKELNTERQIFLEACIVRIMKAKRNLPHTTLV 771
Query: 769 NECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRTDDGECYEYLA 812
NECIA+S QRFNAKVSM+K+A+D+LI++ YL+R DDGE Y YLA
Sbjct: 772 NECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGDDGESYAYLA 815
>Hs4503161 [D] KOG2166 Cullins
Length = 752
Score = 416 bits (1068), Expect = e-115
Identities = 260/804 (32%), Positives = 422/804 (52%), Gaps = 79/804 (9%)
Query: 21 GIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVNKSRSTGHFQSDIIGKQMNQ 80
G+DQI D D + I+ ++ ++ YME+YT +YNYC + +
Sbjct: 16 GLDQIWD-DLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQ---------------- 58
Query: 81 SSILVGGEIYENLKNYLKDYISNLKKDD----NVTFLNFYVRRWERFTIGAIFLNRVFDY 136
VG E+Y+ LK +LK+Y++NL KD + + L FY ++WE + + LN + Y
Sbjct: 59 ---FVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAY 115
Query: 137 MNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQRRGELVNKS 196
+NR+WV++E +G++ I++ ++L L+TW++ +F ++ + ++ +R GE +N
Sbjct: 116 LNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTR 175
Query: 197 AITIAIKSFVILGIDPSD--LKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSE 254
I+ ++S+V LG++ D K L VY ++FE FL T+ +YT+ S EFL + V+E
Sbjct: 176 LISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTE 235
Query: 255 YIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKEFILLLDKQDQRLI 314
Y++KA ++ E++ + +YL T L+ QVLI H + EF LLD +
Sbjct: 236 YMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDL 295
Query: 315 KLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPRD 374
+Y L+ R L +L + +I G I+K ++A D P+
Sbjct: 296 GRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKC----GEAALND----------PKM 341
Query: 375 YLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKFATSRAPEM 434
Y++ ++ V+K + + + F N F ALD C FINNN+ S +S++PE+
Sbjct: 342 YVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQS----SSKSPEL 397
Query: 435 LAKYSDQLLKKSTKNNEQVDL--TVDDIMTVFKFLADKDAFEMHYRKNLAKRLIHGSSKS 492
LA+Y D LLKKS+KN E+ +L T++ +M VFK++ DKD F+ Y K LAKRL+H +S S
Sbjct: 398 LARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSAS 457
Query: 493 EADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSAATFRSK 552
+ E +I +L+ EYTSK+ +M QD+ +SK+L+++F ++ N+ F +
Sbjct: 458 DDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLT---NSEPLDLDFSIQ 514
Query: 553 VPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKWLWPMSRGEI 612
V L+ WPF Q FALP LE S + Y +HSGR L WL+ +S+GE+
Sbjct: 515 V-------LSSGSWPFQ-QSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGEL 566
Query: 613 KAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQIASNMYPFVKMK 672
+ K + + FQMAIL +N T +Q+ + T +K +A + +K K
Sbjct: 567 ---VTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSK 623
Query: 673 LLIQSPEGV---ESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATVNGSALDETE 729
LL+ E E +K DT L Y+ K VN +K + +
Sbjct: 624 LLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTE---------------Q 668
Query: 730 ASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFNAKVSMIKKA 789
EQ+ K + + R + ++A IVRIMK ++ L H L+ E + + RF +V +IKK
Sbjct: 669 KQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKC 728
Query: 790 VDNLIEQEYLKRTD-DGECYEYLA 812
+D LIE+EYL+R D + + Y YLA
Sbjct: 729 IDILIEKEYLERVDGEKDTYSYLA 752
>SPAC17G6.12 [D] KOG2166 Cullins
Length = 767
Score = 413 bits (1061), Expect = e-115
Identities = 253/811 (31%), Positives = 418/811 (51%), Gaps = 68/811 (8%)
Query: 9 DDLEATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVNKSRSTGH 68
D L TW+F+K G+ QI +R + + ++ YME+YTAI+NYC + S++
Sbjct: 18 DSLNGTWDFLKTGVSQIFER----------LDEGMTITKYMELYTAIHNYCADASKTI-- 65
Query: 69 FQSDIIGKQMNQSSILVGGEIYENLKNYLKDYISNLKKD-----DNVTFLNFYVRRWERF 123
+ +Q++ ++G +Y NL YL++Y++ L+K+ ++ L Y + W RF
Sbjct: 66 ----TVDNFNDQTANVLGEALYNNLVLYLEEYLARLRKECISQTNHEEQLAAYAKYWTRF 121
Query: 124 TIGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQ 183
T A F+N +F Y+NRYWV+ + + ++D +TLCL++W +F + L+ +
Sbjct: 122 TTSARFINHLFGYLNRYWVKLKNRFTETLVYDIYTLCLVSWHHHVFSHIRDSLLQNLLYM 181
Query: 184 LDLQRRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMS 243
+R E + + + + S L D +D+ K NL+ Y FE F++ TK +Y K S
Sbjct: 182 FTKKRLYEPTDMKYVEVCVDSITSLSFDKTDMTKPNLSSYKTFFETNFIENTKNFYAKES 241
Query: 244 NEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKEFI 303
+E+L SHS+++Y++KA + EE+ + LYL T PL A VLIA H + L +F
Sbjct: 242 SEYLASHSITDYLKKAEIRLAEEEELVRLYLHESTLKPLLEATEDVLIAQHEEVLHNDFA 301
Query: 304 LLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSN 363
+LD+ I +Y LM R L L TF+ ++KR G + K++ A D
Sbjct: 302 RMLDQNCSEDIIRMYRLMSRTPNGLQPLRQTFEEFVKRSGFAAVAKIVPQVGGEADVD-- 359
Query: 364 AKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGS 423
P++Y++ L+ YK + F F K+LD R +N N
Sbjct: 360 --------PKEYMEMLLSTYKASKELVNTAFHGDTDFTKSLDTAFRELVNRNVVC----- 406
Query: 424 PKFATSRAPEMLAKYSDQLLKKSTKN--NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNL 481
+ ++SR+PE+LAKY+D +L+KS KN + V+ + I+ +F+++ DKD F+ Y K L
Sbjct: 407 -QRSSSRSPELLAKYADSILRKSNKNVDIDDVEDCLSSIIIIFRYVEDKDVFQNFYTKLL 465
Query: 482 AKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGN 541
AKRL++G+S S+ E ++ +L+ EYTSK+ +M QD+ LS+ + + F
Sbjct: 466 AKRLVNGTSNSQDAESSMLSKLKEVCGFEYTSKLQRMFQDISLSQEITEAFWQLPQSRAG 525
Query: 542 NTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRIL 601
N +A L+L + WP S F LP L + Y H+GR L
Sbjct: 526 NIDFSA-----------LVLGTSFWPLSPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKL 574
Query: 602 KWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQI 661
WL+ +S+GEIKA I + F V+ +QM +L L+N + T+E++ + T L +
Sbjct: 575 SWLFHLSKGEIKARINPQTNVTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLSTDFL 634
Query: 662 ASNMYPFVKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATVN 721
+ F+K K+L+ + + ++ Y +N+ +R+ K V ++++
Sbjct: 635 TGILNIFLKAKVLLLGDN--DKLGDPNSTYKINENFRMKKIRVQLNLPIRSE-------- 684
Query: 722 GSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFNA 781
+ E + K + + R + L++ IVRIMKA+R L H L+ E I + + RF
Sbjct: 685 -------QKQESLETHKTIEEDRKLLLQSAIVRIMKARRTLKHVVLVKETIDQIKSRFTP 737
Query: 782 KVSMIKKAVDNLIEQEYLKRTDDGECYEYLA 812
KVS IK+ +D LIE+EYL+R E Y YLA
Sbjct: 738 KVSDIKQCIDMLIEKEYLERQGRDE-YIYLA 767
>7304137 [D] KOG2166 Cullins
Length = 774
Score = 382 bits (980), Expect = e-105
Identities = 245/829 (29%), Positives = 417/829 (49%), Gaps = 79/829 (9%)
Query: 2 ADTLPRSDDLEATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVN 61
+ T + +L+ W+ + GI Q+ + + K L+ YM YT +Y+YC +
Sbjct: 7 SQTTQKLVNLDDIWSELVEGIMQVFEHE-----------KSLTRSQYMRFYTHVYDYCTS 55
Query: 62 KSRSTGHFQSDIIGKQMNQSSILVGGEIYENLKNYLKDYISNLKK-----DDNVTFLNFY 116
S + S G + LVG ++Y+ L+ +LK Y+S L L+ Y
Sbjct: 56 VSAAPSGRSSGKTG-----GAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRY 110
Query: 117 VRRWERFTIGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTEL 176
++W+ + + L+ + +Y+NR WV++E +G++ I+ + L L+ WK +F+ +
Sbjct: 111 TKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPV 170
Query: 177 VTEIFDQLDLQRRGELVNKSAITIAIKSFVILGI--DPSDLKKLNLNVYIQNFEQPFLQK 234
+ ++ +R+G+L+N+S + I+ +V L + +D ++ L+VY QNFE F+
Sbjct: 171 TKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIAD 230
Query: 235 TKEYYTKMSNEFLDSHSVSEYI--------EKANECIIFEEKDMILYLDSHTSAPLSTAL 286
T +Y K S+ FL +++V+EY+ E+ F K+ + YL T+ L +
Sbjct: 231 TSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTC 290
Query: 287 NQVLIADHADKLKKEFILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEE 346
+VLI H EF LL+ +K +Y L+ + L DL + +I G E
Sbjct: 291 EEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEA 350
Query: 347 IDKLIDAHNKSAAQDSNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDY 406
I K AA D P+ Y++ ++ V+K + + + F N F ALD
Sbjct: 351 IAKCCTT---DAAND----------PKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDK 397
Query: 407 GCRCFINNNSFAIPPGSPKFATSRAPEMLAKYSDQLLKKSTKNNEQVDL--TVDDIMTVF 464
C FIN+N I + S++PE+LAKY D LLKKS+KN E +L ++ +M VF
Sbjct: 398 ACGKFINSNVVTIANSA-----SKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVF 452
Query: 465 KFLADKDAFEMHYRKNLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKL 524
K++ DKD F+ +Y K LAKRL++ +S S+ E ++I +L+ EYT K+ +M QD+ +
Sbjct: 453 KYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGV 512
Query: 525 SKNLHDEFSTFISQDGNNTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHS 584
SK+L+ F ++++ N T F +V L+ WPF F LP LE S
Sbjct: 513 SKDLNSYFKQYLAE--KNLTMEIDFGIEV-------LSSGSWPFQLS-NNFLLPSELERS 562
Query: 585 KNKLETMYTDKHSGRILKWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDIST 644
+ Y +HSGR L WL+ M +GE+ ++ + + + FQM++L FND +
Sbjct: 563 VRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLS 622
Query: 645 LTFEQIQERTNLKATQIASNMYPFVKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSV 704
T +Q+Q+ T + + + +K K+L S E+ + ++ L Y+ K +
Sbjct: 623 FTVQQLQDNTQTQQENLIQVLQILLKAKVLTSSDN--ENSLTPESTVELFLDYKNKKRRI 680
Query: 705 NFAAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPH 764
N +K +L EQ+ K + + R + ++A IVRIMK +++L H
Sbjct: 681 NINQPLKTELKV---------------EQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNH 725
Query: 765 SSLMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRTD-DGECYEYLA 812
++L++E + + RF KV +IKK +D LIE+EYL+R + + Y YLA
Sbjct: 726 TNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
>CE29089 [D] KOG2166 Cullins
Length = 780
Score = 357 bits (917), Expect = 3e-98
Identities = 250/840 (29%), Positives = 423/840 (49%), Gaps = 88/840 (10%)
Query: 1 MADTLPR--SDDLEATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNY 58
M ++ PR + D E W ++ G+D R+ ++P+ YM +YT++Y+Y
Sbjct: 1 MTNSEPRRMTCDSEVVWKKLQDGLDVAYRREN------------MAPKDYMTLYTSVYDY 48
Query: 59 CVNKSRST-------GHFQSDIIGKQMNQSSILVGGEIYENLKNYLKDYI-------SNL 104
C + + ST G +S + VG E+Y+ ++ Y+K Y+ + L
Sbjct: 49 CTSITLSTSRRDGEDGRAESSTPARTAGAD--FVGHEMYQRVEEYVKAYVIAVCEKGAEL 106
Query: 105 KKDDNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTW 164
+D L +Y WE F I + ++ +F Y+NR+W+++E +G +I+ +TL L+ W
Sbjct: 107 SGED---LLKYYTTEWENFRISSKVMDGIFAYLNRHWIRRELDEGHENIYMVYTLALVVW 163
Query: 165 KEVMFETHKTELVTEIFDQLDLQRRGELVNKSAITIAIKSFVILGIDPS------DLKKL 218
K +F K +++ + + + +R G ++N I+ ++ V LG+D S D +
Sbjct: 164 KRNLFNDLKDKVIDAMLELIRSERTGSMINSRYISGVVECLVELGVDDSETDAKKDAETK 223
Query: 219 NLNVYIQNFEQPFLQKTKEYYTKMSNEFL-DSHSVSEYIEKANECIIFEEKDMILYLDSH 277
L VY + FE FL+ T+ +YT+ + FL + +V++Y+ K + E+ LYL+S
Sbjct: 224 KLAVYKEFFEVKFLEATRGFYTQEAANFLSNGGNVTDYMIKVETRLNQEDDRCQLYLNSS 283
Query: 278 TSAPLSTALNQVLIADHADKLKKEF-ILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFD 336
T PL+T VLI++ D L++ F LL+DK+D L ++ ++L R L +L + +
Sbjct: 284 TKTPLATCCESVLISNQLDFLQRHFGGLLVDKRDDDLSRM-FKLCDRVPNGLDELRKSLE 342
Query: 337 MYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFEN 396
+I + G++ ++++ AA D+ Y+K L+ V++ + ++ F+N
Sbjct: 343 NHIAKEGHQALERVA----MEAATDAKL----------YVKTLLEVHERYQSLVNRSFKN 388
Query: 397 HPAFAKALDYGCRCFINNNSFAIPPGSPKFATSRAPEMLAKYSDQLLKKSTKNNEQVDL- 455
P F ++LD FINNN+ P+ +++ E+LA+Y DQLL+KS+K ++ +L
Sbjct: 389 EPGFMQSLDKAATSFINNNA-VTKRAPPQAQLTKSAELLARYCDQLLRKSSKMPDEAELE 447
Query: 456 -TVDDIMTVFKFLADKDAFEMHYRKNLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSK 514
IM VFK++ DKD F Y K +KRLI S S+ E I +L+S EYT++
Sbjct: 448 ELQTKIMVVFKYIDDKDVFSKFYTKMFSKRLISELSASDEAEANFITKLKSMCGYEYTAR 507
Query: 515 ITKMLQDVKLSKNLHDEFSTFISQDGNNTTSAATFRSKVPELEPLILADNVWPFSYQPTE 574
++KM+ D ++SK+L +F A K E L+L+ WP ++ T
Sbjct: 508 LSKMVNDTQVSKDLTADF---------KEKKADMLGQKSVEFNVLVLSSGSWP-TFPTTP 557
Query: 575 FALPPVLEHSKNKLETMYTDKHSGRILKWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMA 634
LP L + Y +K +GR L W++ SRGEI + P K + FT T QM
Sbjct: 558 ITLPQQLSKTIEIFGQFYNEKFNGRRLTWVYSQSRGEITS-TAFPKK--YVFTATTAQMC 614
Query: 635 ILTLFNDISTLTFEQIQERTNLKATQIASNMYPFVKMKLLIQSPE-GVESMIKLDTKYTL 693
+ LFN+ + T EQI T + + + +K +L E E + + +L
Sbjct: 615 TMLLFNEQDSYTVEQIAAATKMDEKSAPAIVGSLIKNLVLKADTELQKEDEVPMTATVSL 674
Query: 694 NKPYRLSKTSVNFAAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIV 753
NK Y K V+ + T+ A+ +TE +K + + R + ACIV
Sbjct: 675 NKAYMNKKVRVDLS---------KFTMKQDAVRDTE-----NVQKNVEEDRKSVISACIV 720
Query: 754 RIMKAKRKLPHSSLMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRTD-DGECYEYLA 812
RIMK ++++ H LM E I + RF KV MIK+ + +LIE+EY+ RT+ + YEYLA
Sbjct: 721 RIMKTRKRVQHQQLMTEVITQLSGRFKPKVEMIKRCIGSLIEKEYMLRTEGQKDLYEYLA 780
>CE11928 [D] KOG2166 Cullins
Length = 729
Score = 302 bits (774), Expect = 1e-81
Identities = 226/818 (27%), Positives = 390/818 (47%), Gaps = 107/818 (13%)
Query: 11 LEATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVNKSRSTGHFQ 70
+EA W ++ G++ + R+ +S + YM +Y A+YN C + + +
Sbjct: 3 IEAVWGTLQDGLNLLYRREH------------MSKKYYMMLYDAVYNICTTTTLANSN-- 48
Query: 71 SDIIGKQMNQSSILVGGEIYENLKNYLKDYISNLKKDDNVT------FLNFYVRRWERFT 124
N S +Y+ L+NY++ Y+ ++ D ++ L W+ F
Sbjct: 49 --------NNSPEFASEFLYKQLENYIRTYVIAIR--DRISACSGDELLGKCTIEWDNFK 98
Query: 125 IGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQL 184
N +F Y+NR +V K+ D I + + L L WK F+ K + + I + +
Sbjct: 99 FSTRICNCIFQYLNRNFVSKKVEDKNGEIVEIYKLALDIWKAEFFDNFKVKTIDAILELI 158
Query: 185 DLQRRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSN 244
L+R G +N + I+ ++ L++Y +FE FL TK +Y +
Sbjct: 159 LLERCGSTINSTHISSVVECLT------------ELDIYKVSFEPQFLDATKLFYKQ--- 203
Query: 245 EFLDS-HSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKEFI 303
E L+S +V EY+ + EE YL T+ L + +LI+D L EF
Sbjct: 204 EVLNSKETVIEYMITVENRLFQEEYRSRRYLGPSTNDLLIDSCESILISDRLKFLHSEFE 263
Query: 304 LLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSN 363
LL+ + + +Y L +R L DL + I + G+E + +L A+DS
Sbjct: 264 RLLEARKDEHLTRMYSLCRRVTHGLEDLRVYLEKRILKEGHETLQRL--------AKDSG 315
Query: 364 AKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGS 423
K +P++Y+ L+ V+++++N+ + F+ + F ++LD + FI N+ +
Sbjct: 316 LKT----TPKEYITKLLEVHEIYFNLINKAFDRNALFMQSLDKASKDFIEANAVTML-AP 370
Query: 424 PKFATSRAPEMLAKYSDQLLKKSTKNNEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAK 483
K ++R+ + LA+Y DQLLKK++K ++ L D +TV K++++KD F+++Y+ ++
Sbjct: 371 EKHRSTRSADYLARYCDQLLKKNSKVQDETAL--DKALTVLKYISEKDVFQLYYQNWFSE 428
Query: 484 RLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNT 543
R+I+ SS S+ EE I L + LEYT + KM++D K+SK+L EF ++
Sbjct: 429 RIINNSSASDDAEEKFITNLTATEGLEYTRNLVKMVEDAKISKDLTTEFKDIKTE----- 483
Query: 544 TSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKW 603
K + ++ WP S + LP L + +T Y H+GR L W
Sbjct: 484 --------KSIDFNVILQTTGAWP-SLDQIKIILPRELSTILKEFDTFYNASHNGRRLNW 534
Query: 604 LWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQ---ERTNLKATQ 660
+ RGE+ + K + + F VT Q+ L LFN+ + T EQI E T +
Sbjct: 535 AYSQCRGEVNS---KAFEKKYVFIVTASQLCTLYLFNEQDSFTIEQISKAIEMTAKSTSA 591
Query: 661 IASNMYPFVKMKLLI---QSPEGV--ESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLT 715
I ++ P + L++ +G ++++ L+TKY K V+ DLT
Sbjct: 592 IVGSLNPVIDPVLVVDKGNEKDGYPPDAVVSLNTKYANKK--------------VRVDLT 637
Query: 716 FTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAES 775
TA +A ET+A + + R ++ACIVRIMK ++ L H+ L+NE I++
Sbjct: 638 -TAIKKATADRETDA-----VQNTVESDRKYEIKACIVRIMKTRKSLTHTLLINEIISQL 691
Query: 776 QQRFNAKVSMIKKAVDNLIEQEYLKRTD-DGECYEYLA 812
+ RF V MIK ++ LIEQ Y++R++ + YEYLA
Sbjct: 692 KSRFTPNVQMIKICIEILIEQLYIRRSENEHNVYEYLA 729
>Hs19482174 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component
Length = 745
Score = 288 bits (738), Expect = 2e-77
Identities = 203/748 (27%), Positives = 363/748 (48%), Gaps = 75/748 (10%)
Query: 85 VGGEIYENLKNYLKDYISNLKK---DDNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRYW 141
+G +Y K +L++++ +L K + L Y R WE ++ GA +++ ++ Y+N +
Sbjct: 53 LGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQF 112
Query: 142 VQKERS------------DGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQRR 189
++K + D + + L L W+++M E + L+ + ++ R
Sbjct: 113 IKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRG 172
Query: 190 GELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDS 249
GE N+ I I SFV + KK L Y + FE PFL +T EYY + ++ L
Sbjct: 173 GEDPNQKVIHGVINSFVHV---EQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQE 229
Query: 250 HSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKEFILLLDKQ 309
+ S+Y+EK + EE YL + + Q ++ADH L E ++ ++
Sbjct: 230 SNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQE 289
Query: 310 DQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPG 369
+ + +Y L++ LP ++ +I H++ SN ++
Sbjct: 290 KKNDMANMYVLLRAVSTGLPHMIQELQNHI--------------HDEGLRATSNLTQEN- 334
Query: 370 LSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKFATS 429
P +++ ++ V+ F + F ALD +N PK +
Sbjct: 335 -MPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYRE-------PK-SVC 385
Query: 430 RAPEMLAKYSDQLLKKSTKN--NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLIH 487
+APE+LAKY D LLKKS K +V+ + +TVFK++ DKD F+ Y + LAKRLIH
Sbjct: 386 KAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIH 445
Query: 488 GSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSAA 547
G S S EE +I +L+ E+TSK+ +M D+ +S +L+++F+ FI
Sbjct: 446 GLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGI 505
Query: 548 TFRSKVPELEPLILADNVWPFSYQPTE-FALPPVLEHSKNKLETMYTDKHSGRILKWLWP 606
+F + +L WP + P+ FA+P LE S E Y+ SGR L WL
Sbjct: 506 SF-------QIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHY 558
Query: 607 MSRGEIKA-HIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQIASNM 665
+ GE+K ++GK P+ VT +QMA+L FN+ T++++++Q+ T + ++ +
Sbjct: 559 LCTGEVKMNYLGK----PYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTI 614
Query: 666 YPFVKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATVNGSAL 725
+ +K++ E + I ++ ++LN + +T +++ D
Sbjct: 615 KSLLDVKMINHDSE--KEDIDAESSFSLNMNFSSKRTKFKITTSMQKD------------ 660
Query: 726 DETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFNAKVSM 785
E ++ +++ R M+L+A IVRIMKA++ L H++L+ E I++S+ RFN +SM
Sbjct: 661 ---TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISM 717
Query: 786 IKKAVDNLIEQEYLKRTD-DGECYEYLA 812
IKK ++ LI+++Y++R+ + Y Y+A
Sbjct: 718 IKKCIEVLIDKQYIERSQASADEYSYVA 745
>7302125 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component
Length = 703
Score = 253 bits (647), Expect = 6e-67
Identities = 193/716 (26%), Positives = 334/716 (45%), Gaps = 69/716 (9%)
Query: 113 LNFYVRRWERFTIGAIFLNRVFDYMNRYWVQKER-----------SDGKRHIFDAHTLCL 161
L Y W ++ G +L++++ Y+N+ ++K++ S + L L
Sbjct: 41 LQRYYITWMEYSQGIKYLHQLYIYLNQQHIKKQKITDTESFYGNLSSDAAEQMEIGELGL 100
Query: 162 MTWKEVMFETHKTELVTEIFDQLDLQRRGELVNKSAITIAIKSFVILGIDPSDLKKL-NL 220
W+ M E +ELV I + + R I + ++ D KK +L
Sbjct: 101 DIWRLYMIEYLSSELVRHILEGIAADRASNGTLDHHRVQIINGVIHSFVEVQDYKKTGSL 160
Query: 221 NVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSA 280
+Y + FE P L+ + YYT +N+ L SVSEY+++ + +E + +L +
Sbjct: 161 KLYQELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLP 220
Query: 281 PLSTALNQVLIADHADKLKKEFILLLDKQDQRLIKLIYELMKR-DYRMLPDLVDTFDMYI 339
L + I D + E ++ ++ ++ ++ +Y ++K + +L+ TF +I
Sbjct: 221 KLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVLKPIPDNLKSELITTFLDHI 280
Query: 340 KRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPA 399
K G + + L + A +++ ++ V+ + + + FEN
Sbjct: 281 KSEGLQTVSALKGENIHIA----------------FVENMLKVHHKYQELIADVFENDSL 324
Query: 400 FAKALDYGCRCFINNNSFAIPPGSPKFATSRAPEMLAKYSDQLLKKSTKNNEQVDLTVDD 459
F ALD C IN P R+ E +AKY D LLKKS ++D + +
Sbjct: 325 FLSALDKACASVINRRPTERQP-------CRSAEYVAKYCDTLLKKSKTCEAEIDQKLTN 377
Query: 460 IMTVFKFLADKDAFEMHYRKNLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKML 519
+T+FK++ DKD ++ Y + LAKRLIH S+S EE +I RL+ E+T+K+ +M
Sbjct: 378 NITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMF 437
Query: 520 QDVKLSKNLHDEFSTFISQDGNNTTSAATFRSKVPELEPLILADNVWPF-SYQPTEFALP 578
D+ +S +L+++F+T + + + KV L WP S Q FA+P
Sbjct: 438 TDISVSVDLNNKFNTHLKDSNVDLDAGINLAIKV-------LQAGAWPLGSTQVIPFAVP 490
Query: 579 PVLEHSKNKLETMYTDKHSGRILKWLWPMSRGEIK-AHIGKPGKPPFQFTVTIFQMAILT 637
E S E Y SGR L WL M GE+K +H+ K + T+ +QMAI+
Sbjct: 491 QEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHL----KKSYIVTMQTYQMAIIL 546
Query: 638 LFNDISTLTFEQIQERTNLKATQIASNMYPFVKMKLLIQSPEGVESMIKLDTKYTLNKPY 697
LF +L+ +IQ L +M P ++ KLL S E + +T+ LN Y
Sbjct: 547 LFETCDSLSCREIQNTLQLNDETFQKHMQPIIESKLLNASSENLAG----ETRIELNLDY 602
Query: 698 RLSKTSVNFAAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMK 757
+T + SAL + E + +++ R +FL+A IVRIMK
Sbjct: 603 TNKRTKFKIS---------------SALQKETPQEVEHTINSVDEDRKLFLQAAIVRIMK 647
Query: 758 AKRKLPHSSLMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRT-DDGECYEYLA 812
A++ L H++L+ E ++ S+ F ++MIKK V++LI+++Y++RT + G+ Y Y+A
Sbjct: 648 ARKVLKHNALIQEVLSLSKVSFTPNIAMIKKCVESLIDKQYIERTANSGDEYSYMA 703
>At1g69670 [D] KOG2166 Cullins
Length = 732
Score = 246 bits (628), Expect = 1e-64
Identities = 200/745 (26%), Positives = 356/745 (46%), Gaps = 95/745 (12%)
Query: 86 GGEIYENLKN----YLKDYISNLKKDDNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRYW 141
G ++Y L +LK+ ++++ FL R+W + + YM+R +
Sbjct: 65 GDKLYTGLVTTMTFHLKEICKSIEEAQGGAFLELLNRKWNDHNKALQMIRDILMYMDRTY 124
Query: 142 VQKERSDGKRHIFDAHTLCLMTWKEVMFETHK--TELVTEIFDQLDLQRRGELVNKSAIT 199
V + K H+ H L L W++ + + K T L+ + D + +R GE++++ +
Sbjct: 125 VSTTK---KTHV---HELGLHLWRDNVVYSSKIQTRLLNTLLDLVHKERTGEVIDRVLMR 178
Query: 200 IAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEKA 259
IK F+ LG +VY +FE+PFL+ + E+Y S EF++S EY++KA
Sbjct: 179 NVIKMFMDLGE----------SVYQDDFEKPFLEASAEFYKVESMEFIESCDCGEYLKKA 228
Query: 260 NECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKEF------ILLLDKQDQRL 313
+ ++ E + ++ YLD+ + A +++ + + +IA+H +L +LL DK +
Sbjct: 229 EKPLVEEVERVVNYLDAKSEAKITSVVEREMIANHVQRLVHMENSGLVNMLLNDKYED-- 286
Query: 314 IKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPR 373
+ +Y L +R L + D ++++ +G + L+ KS P
Sbjct: 287 MGRMYSLFRRVANGLVTVRDVMTLHLREMGKQ----LVTDPEKSK------------DPV 330
Query: 374 DYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKFATSRAPE 433
++++ L+ + I F N F AL+ F+N N+ R+PE
Sbjct: 331 EFVQRLLDERDKYDRIINMAFNNDKTFQNALNSSFEYFVNLNT-------------RSPE 377
Query: 434 MLAKYSDQLLKKSTKN--NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLIHGSSK 491
++ + D L+K K E VDL +D +M +F++L +KD FE +Y+++LAKRL+ G +
Sbjct: 378 FISLFVDDKLRKGLKGVGEEDVDLILDKVMMLFRYLQEKDVFEKYYKQHLAKRLLSGKTV 437
Query: 492 SEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSAATFRS 551
S+ E +I +L++E ++TSK+ M D+K S HD F + S
Sbjct: 438 SDDAERNLIVKLKTECGYQFTSKLEGMFTDMKTS---HDTLLGFYNSHPE--------LS 486
Query: 552 KVPELEPLILADNVWPFSYQPT-EFALPPVLEHSKNKLETMYTDKHSGRILKWLWPMSRG 610
+ P L +L WP QPT + LP + K + Y H+GR L W M
Sbjct: 487 EGPTLVVQVLTTGSWP--TQPTIQCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTNMGTA 544
Query: 611 EIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQIASNMYPF-- 668
+IKA GK K + V+ FQM +L LFN+ L++++I++ T + + +
Sbjct: 545 DIKAVFGKGQK--HELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPTPDLKRCLQSMAC 602
Query: 669 VKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATVNGSALDET 728
VK K +++ E + I + + +N + V V A ET
Sbjct: 603 VKGKNVLRK-EPMSKEIAEEDWFVVNDRFASKFYKVKIGTVV-------------AQKET 648
Query: 729 EASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFNAKVSMIKK 788
E E+++ + + + R + A IVRIMK++R L H++++ E + Q RF A + IKK
Sbjct: 649 E-PEKQETRQRVEEDRKPQIEAAIVRIMKSRRVLDHNNIIAEVTKQLQTRFLANPTEIKK 707
Query: 789 AVDNLIEQEYLKRTD-DGECYEYLA 812
+++LIE+++L+R + D + Y YLA
Sbjct: 708 RIESLIERDFLERDNTDRKLYRYLA 732
>Hs4503165 [D] KOG2166 Cullins
Length = 768
Score = 238 bits (607), Expect = 3e-62
Identities = 191/767 (24%), Positives = 350/767 (44%), Gaps = 108/767 (14%)
Query: 86 GGEIYENLKNYLKDYISNLKKDD-----NVTFLNFYVRRWERFTIGAIFLNRVFDYMNRY 140
G ++Y L+ + +++ N ++D N FL + W + + + YM+R
Sbjct: 70 GEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRV 129
Query: 141 WVQKERSDGKRHIFDAHTLCLMTWKE--VMFETHKTELVTEIFDQLDLQRRGELVNKSAI 198
+VQ+ ++ + + L L+ +++ V + + L + D + +R+GE+V++ AI
Sbjct: 130 YVQQN------NVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAI 183
Query: 199 TIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEK 258
A + +ILG++ +VY ++FE PFL+ + E++ S +FL +S S YI+K
Sbjct: 184 RNACQMLMILGLE-------GRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKK 236
Query: 259 ANECIIFEEKDMILY-LDSHTSAPLSTALNQVLIADHADKL----KKEFILLLDKQDQRL 313
E I EE + +++ LD T P+ + + LI+ H + + +L
Sbjct: 237 V-EARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTED 295
Query: 314 IKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPR 373
+ +Y+L R L + + Y++ G + ++ G +P
Sbjct: 296 LGCMYKLFSRVPNGLKTMCECMSSYLREQGKALV----------------SEEGEGKNPV 339
Query: 374 DYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKFATSRAPE 433
DY++ L+ + F +E F N F + + F+N NS R+PE
Sbjct: 340 DYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-------------RSPE 386
Query: 434 MLAKYSDQLLKKSTKN--NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLIHGSSK 491
L+ + D LKK K ++V+ +D M +F+F+ +KD FE +Y+++LA+RL+ S
Sbjct: 387 YLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSV 446
Query: 492 SEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSAATFRS 551
S+ E+ +I +L++E ++TSK+ M +D+ +S DEF + G +
Sbjct: 447 SDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGV----- 501
Query: 552 KVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKWLWPMSRGE 611
+L +L WP + +PP H+ Y KHSGR L M +
Sbjct: 502 ---DLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSAD 558
Query: 612 IKAHIGKP---------GKPPFQFT----------VTIFQMAILTLFNDISTLTFEQIQE 652
+ A P G Q T V+ FQM IL LFN+ TFE+IQ+
Sbjct: 559 LNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQ 618
Query: 653 RTNLKATQIASNMYPFV----KMKLLIQSPEGVESMIKLDTKYTLNKPY--RLSKTSVNF 706
T++ ++ + ++L + P+ E I+ +T+N + +L + +
Sbjct: 619 ETDIPERELVRALQSLACGKPTQRVLTKEPKSKE--IENGHIFTVNDQFTSKLHRVKIQT 676
Query: 707 AAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSS 766
AA + + E+K+ ++++ R + A IVRIMK+++K+ H+
Sbjct: 677 VAAKQGE---------------SDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNV 721
Query: 767 LMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRT-DDGECYEYLA 812
L+ E + + RF +IKK ++ LIE+EYL RT +D + Y Y+A
Sbjct: 722 LVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
>CE25691 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component
Length = 804
Score = 238 bits (606), Expect = 4e-62
Identities = 191/757 (25%), Positives = 347/757 (45%), Gaps = 119/757 (15%)
Query: 89 IYENLKNYLKDYISNLKKD----DNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRYWVQK 144
+Y +K +++++ ++D D L Y + W F GAIF++R+F Y+N+ +V++
Sbjct: 134 LYNEVKACIQEHVRQKRQDIVDVDPDLLLQEYHKMWRVFHEGAIFIHRLFGYLNKQFVKQ 193
Query: 145 ERSDGKRH------------IFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQRRGEL 192
+R + + + L L WKE + +T +LV + +D R+G
Sbjct: 194 KRCTDLDNFAQYAAFLQIPDVKEIGCLALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNF 253
Query: 193 VN-KSAITIAIKSFVILGIDPSDL----------KKLNLNVYIQNFEQPFLQKTKEYYTK 241
+ + ++ I SFV + D+ ++ Y ++FE+P L T++YY+
Sbjct: 254 PHIANEVSGVINSFVKMEETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSA 313
Query: 242 MSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKE 301
++ + L S SEY+E+ + EE YL + + T +V+I H DKL
Sbjct: 314 LAQKMLTDLSCSEYMEQVIVLLEQEEMRAKKYLHESSVEKVITLCQKVMIKAHKDKLHAV 373
Query: 302 FILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQD 361
L+ ++ + ++ +Y L+K L +V F+ Y+K+ G E + +L +
Sbjct: 374 CHDLITNEENKDLRNMYRLLKPIQAGLSVMVKEFEEYVKKKGLEAVSRLTGEN------- 426
Query: 362 SNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPP 421
P+ +++ ++ VY F ++ F + F+ LD + +N+
Sbjct: 427 ---------VPQQFVENVLRVYNKFNDMKTAVFMDDGEFSSGLDKALQGVVNSK------ 471
Query: 422 GSPKFATSRAPEMLAKYSDQLLKKSTKNNEQVDL--TVDDIMTVFKFLADKDAFEMHYRK 479
P + +A E LA+Y+D LLKKSTK + DL +D + +F+++ DKD F+ Y K
Sbjct: 472 -EPGQSVPKASERLARYTDGLLKKSTKGLSETDLEAKLDSAIVIFRYIEDKDIFQKFYSK 530
Query: 480 NLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQD 539
LA RLI +S S EE++I +L+ E+TS + L +LS N
Sbjct: 531 MLANRLIASTSISMDAEELMINKLKQACGYEFTS--SWPLNAPQLSTN------------ 576
Query: 540 GNNTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGR 599
NN T + F LP +L+ + E YT KH+GR
Sbjct: 577 SNNQT------------------------AQDVANFHLPRILQPVIQEFEKFYTGKHNGR 612
Query: 600 ILKWLWPMSRGEIK-AHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKA 658
L WL+ MS+G+++ ++ K + + ++QMA L F + + I E +
Sbjct: 613 KLTWLFNMSQGDVRLTYLDK----QYVAQMYVYQMAALLCFERRDAILVKDIGEEIGVSG 668
Query: 659 TQIASNMYPFVKMKLLIQSPEGV--ESMIKLDTKYTLNK-PYRLSKTSVNFAAAVKNDLT 715
+ + + + LL + + +S+++L+ T + +RL VN A
Sbjct: 669 DYLLKTIRTILDVTLLTCDDQNLTADSLVRLNMSMTSKRMKFRLQAPQVNKAV------- 721
Query: 716 FTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAES 775
EQ+ ++Q R ++ IVRIMK ++ L H++L+ E + ++
Sbjct: 722 --------------EKEQEAVANTVSQDRKYYMECAIVRIMKTRKVLKHNALVTEIMDQT 767
Query: 776 QQRFNAKVSMIKKAVDNLIEQEYLKRTDDGECYEYLA 812
+ RF+ V IKK++++LIE+ Y++RTD + Y+YLA
Sbjct: 768 KGRFSPDVPFIKKSIEDLIEKMYIQRTDQNDEYQYLA 804
>CE24730 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component
Length = 728
Score = 238 bits (606), Expect = 4e-62
Identities = 191/757 (25%), Positives = 347/757 (45%), Gaps = 119/757 (15%)
Query: 89 IYENLKNYLKDYISNLKKD----DNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRYWVQK 144
+Y +K +++++ ++D D L Y + W F GAIF++R+F Y+N+ +V++
Sbjct: 58 LYNEVKACIQEHVRQKRQDIVDVDPDLLLQEYHKMWRVFHEGAIFIHRLFGYLNKQFVKQ 117
Query: 145 ERSDGKRH------------IFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQRRGEL 192
+R + + + L L WKE + +T +LV + +D R+G
Sbjct: 118 KRCTDLDNFAQYAAFLQIPDVKEIGCLALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNF 177
Query: 193 VN-KSAITIAIKSFVILGIDPSDL----------KKLNLNVYIQNFEQPFLQKTKEYYTK 241
+ + ++ I SFV + D+ ++ Y ++FE+P L T++YY+
Sbjct: 178 PHIANEVSGVINSFVKMEETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSA 237
Query: 242 MSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKE 301
++ + L S SEY+E+ + EE YL + + T +V+I H DKL
Sbjct: 238 LAQKMLTDLSCSEYMEQVIVLLEQEEMRAKKYLHESSVEKVITLCQKVMIKAHKDKLHAV 297
Query: 302 FILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQD 361
L+ ++ + ++ +Y L+K L +V F+ Y+K+ G E + +L +
Sbjct: 298 CHDLITNEENKDLRNMYRLLKPIQAGLSVMVKEFEEYVKKKGLEAVSRLTGEN------- 350
Query: 362 SNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPP 421
P+ +++ ++ VY F ++ F + F+ LD + +N+
Sbjct: 351 ---------VPQQFVENVLRVYNKFNDMKTAVFMDDGEFSSGLDKALQGVVNSK------ 395
Query: 422 GSPKFATSRAPEMLAKYSDQLLKKSTKNNEQVDL--TVDDIMTVFKFLADKDAFEMHYRK 479
P + +A E LA+Y+D LLKKSTK + DL +D + +F+++ DKD F+ Y K
Sbjct: 396 -EPGQSVPKASERLARYTDGLLKKSTKGLSETDLEAKLDSAIVIFRYIEDKDIFQKFYSK 454
Query: 480 NLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQD 539
LA RLI +S S EE++I +L+ E+TS + L +LS N
Sbjct: 455 MLANRLIASTSISMDAEELMINKLKQACGYEFTS--SWPLNAPQLSTN------------ 500
Query: 540 GNNTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGR 599
NN T + F LP +L+ + E YT KH+GR
Sbjct: 501 SNNQT------------------------AQDVANFHLPRILQPVIQEFEKFYTGKHNGR 536
Query: 600 ILKWLWPMSRGEIK-AHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKA 658
L WL+ MS+G+++ ++ K + + ++QMA L F + + I E +
Sbjct: 537 KLTWLFNMSQGDVRLTYLDK----QYVAQMYVYQMAALLCFERRDAILVKDIGEEIGVSG 592
Query: 659 TQIASNMYPFVKMKLLIQSPEGV--ESMIKLDTKYTLNK-PYRLSKTSVNFAAAVKNDLT 715
+ + + + LL + + +S+++L+ T + +RL VN A
Sbjct: 593 DYLLKTIRTILDVTLLTCDDQNLTADSLVRLNMSMTSKRMKFRLQAPQVNKAV------- 645
Query: 716 FTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAES 775
EQ+ ++Q R ++ IVRIMK ++ L H++L+ E + ++
Sbjct: 646 --------------EKEQEAVANTVSQDRKYYMECAIVRIMKTRKVLKHNALVTEIMDQT 691
Query: 776 QQRFNAKVSMIKKAVDNLIEQEYLKRTDDGECYEYLA 812
+ RF+ V IKK++++LIE+ Y++RTD + Y+YLA
Sbjct: 692 KGRFSPDVPFIKKSIEDLIEKMYIQRTDQNDEYQYLA 728
>CE16729 [O] KOG2284 E3 ubiquitin ligase Cullin 2 component
Length = 745
Score = 238 bits (606), Expect = 4e-62
Identities = 191/757 (25%), Positives = 347/757 (45%), Gaps = 119/757 (15%)
Query: 89 IYENLKNYLKDYISNLKKD----DNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRYWVQK 144
+Y +K +++++ ++D D L Y + W F GAIF++R+F Y+N+ +V++
Sbjct: 75 LYNEVKACIQEHVRQKRQDIVDVDPDLLLQEYHKMWRVFHEGAIFIHRLFGYLNKQFVKQ 134
Query: 145 ERSDGKRH------------IFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQRRGEL 192
+R + + + L L WKE + +T +LV + +D R+G
Sbjct: 135 KRCTDLDNFAQYAAFLQIPDVKEIGCLALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNF 194
Query: 193 VN-KSAITIAIKSFVILGIDPSDL----------KKLNLNVYIQNFEQPFLQKTKEYYTK 241
+ + ++ I SFV + D+ ++ Y ++FE+P L T++YY+
Sbjct: 195 PHIANEVSGVINSFVKMEETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSA 254
Query: 242 MSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKE 301
++ + L S SEY+E+ + EE YL + + T +V+I H DKL
Sbjct: 255 LAQKMLTDLSCSEYMEQVIVLLEQEEMRAKKYLHESSVEKVITLCQKVMIKAHKDKLHAV 314
Query: 302 FILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQD 361
L+ ++ + ++ +Y L+K L +V F+ Y+K+ G E + +L +
Sbjct: 315 CHDLITNEENKDLRNMYRLLKPIQAGLSVMVKEFEEYVKKKGLEAVSRLTGEN------- 367
Query: 362 SNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPP 421
P+ +++ ++ VY F ++ F + F+ LD + +N+
Sbjct: 368 ---------VPQQFVENVLRVYNKFNDMKTAVFMDDGEFSSGLDKALQGVVNSK------ 412
Query: 422 GSPKFATSRAPEMLAKYSDQLLKKSTKNNEQVDL--TVDDIMTVFKFLADKDAFEMHYRK 479
P + +A E LA+Y+D LLKKSTK + DL +D + +F+++ DKD F+ Y K
Sbjct: 413 -EPGQSVPKASERLARYTDGLLKKSTKGLSETDLEAKLDSAIVIFRYIEDKDIFQKFYSK 471
Query: 480 NLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQD 539
LA RLI +S S EE++I +L+ E+TS + L +LS N
Sbjct: 472 MLANRLIASTSISMDAEELMINKLKQACGYEFTS--SWPLNAPQLSTN------------ 517
Query: 540 GNNTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGR 599
NN T + F LP +L+ + E YT KH+GR
Sbjct: 518 SNNQT------------------------AQDVANFHLPRILQPVIQEFEKFYTGKHNGR 553
Query: 600 ILKWLWPMSRGEIK-AHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKA 658
L WL+ MS+G+++ ++ K + + ++QMA L F + + I E +
Sbjct: 554 KLTWLFNMSQGDVRLTYLDK----QYVAQMYVYQMAALLCFERRDAILVKDIGEEIGVSG 609
Query: 659 TQIASNMYPFVKMKLLIQSPEGV--ESMIKLDTKYTLNK-PYRLSKTSVNFAAAVKNDLT 715
+ + + + LL + + +S+++L+ T + +RL VN A
Sbjct: 610 DYLLKTIRTILDVTLLTCDDQNLTADSLVRLNMSMTSKRMKFRLQAPQVNKAV------- 662
Query: 716 FTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAES 775
EQ+ ++Q R ++ IVRIMK ++ L H++L+ E + ++
Sbjct: 663 --------------EKEQEAVANTVSQDRKYYMECAIVRIMKTRKVLKHNALVTEIMDQT 708
Query: 776 QQRFNAKVSMIKKAVDNLIEQEYLKRTDDGECYEYLA 812
+ RF+ V IKK++++LIE+ Y++RTD + Y+YLA
Sbjct: 709 KGRFSPDVPFIKKSIEDLIEKMYIQRTDQNDEYQYLA 745
>At1g26830 [D] KOG2166 Cullins
Length = 732
Score = 231 bits (588), Expect = 4e-60
Identities = 204/819 (24%), Positives = 376/819 (45%), Gaps = 130/819 (15%)
Query: 12 EATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVNKSRSTGHFQS 71
+ TW ++ I QI ++D S + E+Y YN ++K
Sbjct: 26 DKTWQILERAIHQIYNQDA-------------SGLSFEELYRNAYNMVLHK--------- 63
Query: 72 DIIGKQMNQSSILVGGEIYENLKNYLKDYISNLKKDDNVTFLNFYVRRWERFTIGAIFLN 131
G+++ I + ++LK+ ++ +FL ++W +
Sbjct: 64 --FGEKLYTGFIAT-------MTSHLKEKSKLIEAAQGGSFLEELNKKWNEHNKALEMIR 114
Query: 132 RVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKE--VMFETHKTELVTEIFDQLDLQRR 189
+ YM+R +++ + K H+ H + L W++ V F T L+ + D + +R
Sbjct: 115 DILMYMDRTYIESTK---KTHV---HPMGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERI 168
Query: 190 GELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDS 249
GE++++ + IK F+ LG +VY ++FE+PFL + E+Y S EF++S
Sbjct: 169 GEVIDRGLMRNVIKMFMDLGE----------SVYQEDFEKPFLDASSEFYKVESQEFIES 218
Query: 250 HSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKEF------I 303
+Y++K+ + + E + + YLD+ + +++ + + +IA+H +L +
Sbjct: 219 CDCGDYLKKSEKRLTEEIERVAHYLDAKSEEKITSVVEKEMIANHMQRLVHMENSGLVNM 278
Query: 304 LLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSN 363
LL DK + + +Y L +R L + D +++ +G + L+ KS
Sbjct: 279 LLNDKYED--LGRMYNLFRRVTNGLVTVRDVMTSHLREMGKQ----LVTDPEKSK----- 327
Query: 364 AKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGS 423
P ++++ L+ + I F N F AL+ FIN N+
Sbjct: 328 -------DPVEFVQRLLDERDKYDKIINTAFGNDKTFQNALNSSFEYFINLNA------- 373
Query: 424 PKFATSRAPEMLAKYSDQLLKKSTKNNEQVDLTV--DDIMTVFKFLADKDAFEMHYRKNL 481
R+PE ++ + D L+K K VD+ V D +M +F++L +KD FE +Y+++L
Sbjct: 374 ------RSPEFISLFVDDKLRKGLKGITDVDVEVILDKVMMLFRYLQEKDVFEKYYKQHL 427
Query: 482 AKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGN 541
AKRL+ G + S+ E +I +L++E ++TSK+ M D+K S++ F
Sbjct: 428 AKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSEDTMRGF--------- 478
Query: 542 NTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRIL 601
+ S+ P L +L WP + LP + K + Y H+GR L
Sbjct: 479 --YGSHPELSEGPTLIVQVLTTGSWP-TQPAVPCNLPAEVSVLCEKFRSYYLGTHTGRRL 535
Query: 602 KWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQI 661
W M +IKA GK K + V+ FQM +L LFN+ L++++I++ T + A +
Sbjct: 536 SWQTNMGTADIKAIFGKGQK--HELNVSTFQMCVLMLFNNSDRLSYKEIEQATEIPAADL 593
Query: 662 ASNMYPF--VKMKLLIQSPE-----GVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDL 714
+ VK K +I+ G E + ++ K+T +K Y++ +V
Sbjct: 594 KRCLQSLACVKGKNVIKKEPMSKDIGEEDLFVVNDKFT-SKFYKVKIGTV---------- 642
Query: 715 TFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAE 774
A ETE E+++ + + + R + A IVRIMK+++ L H++++ E +
Sbjct: 643 --------VAQKETE-PEKQETRQRVEEDRKPQIEAAIVRIMKSRKILDHNNIIAEVTKQ 693
Query: 775 SQQRFNAKVSMIKKAVDNLIEQEYLKR-TDDGECYEYLA 812
Q RF A + IKK +++LIE+++L+R + D + Y YLA
Sbjct: 694 LQPRFLANPTEIKKRIESLIERDFLERDSTDRKLYRYLA 732
>Hs13270467 [D] KOG2167 Cullins
Length = 717
Score = 218 bits (555), Expect = 3e-56
Identities = 195/754 (25%), Positives = 349/754 (45%), Gaps = 106/754 (14%)
Query: 79 NQSSILVGGEIYENLKNYLKDYIS----NLKKD--DNVTFLNFYVRRWERFTIGAIFLNR 132
N S + +Y+ L+ +D+I ++D D+V FL R W+ I +
Sbjct: 50 NLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRS 109
Query: 133 VFDYMNRYWVQKERS-----DGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQ 187
+F +++R +V + D +F AH +++ ++V +T + I ++ +
Sbjct: 110 IFLFLDRTYVLQNSMLPSIWDMGLELFRAH---IISDQKVQNKT-----IDGILLLIERE 161
Query: 188 RRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFL 247
R GE +++S + + SDL+ +Y +FEQ FL++T Y + +
Sbjct: 162 RNGEAIDRSLLRSLLSML-------SDLQ-----IYQDSFEQRFLEETNRLYAAEGQKLM 209
Query: 248 DSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADK-LKKEFILLL 306
V EY+ N+ + E +I YLD T L + + L+ +H L+K LL
Sbjct: 210 QEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLL 269
Query: 307 DKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKR 366
D+ + + L+Y+L R + L+ + YIK G+ + + +K+ Q+
Sbjct: 270 DENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIV--INPEKDKTMVQEL---- 323
Query: 367 QPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKF 426
L +D + +I + CF + F A+ FIN P P
Sbjct: 324 ---LDFKDKVDHIIDI----------CFLKNEKFINAMKEAFETFINKR-----PNKPA- 364
Query: 427 ATSRAPEMLAKYSDQLLKKSTKN--NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKR 484
E++AKY D L+ K +E+++ +D IM +F+F+ KD FE Y+K+LAKR
Sbjct: 365 ------ELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKR 418
Query: 485 LIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTT 544
L+ G S S E+ ++ +L+ E +TSK+ M +D++LSK++ +F ++
Sbjct: 419 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQ------- 471
Query: 545 SAATFRSKVP---ELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRIL 601
VP EL IL WP +Y P E LPP + + +T Y KHSGR L
Sbjct: 472 -----NQNVPGNIELTVNILTMGYWP-TYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKL 525
Query: 602 KWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQI 661
+W + +KA K GK Q V++FQ +L +FN+ + E+I++ T ++ ++
Sbjct: 526 QWQSTLGHCVLKAEF-KEGKKELQ--VSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL 582
Query: 662 ASNMYPFV--KMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTAT 719
+ K ++L ++P+G + I+ K+ N ++ F
Sbjct: 583 RRTLQSLACGKARVLAKNPKGKD--IEDGDKFICNDDFK--------------HKLFRIK 626
Query: 720 VNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRF 779
+N + ET EQ + + Q R + A IVRIMK ++ L H+ L++E +Q +F
Sbjct: 627 INQIQMKET-VEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSE--VYNQLKF 683
Query: 780 NAKVSMIKKAVDNLIEQEYLKR-TDDGECYEYLA 812
K + +KK +++LI+++Y++R ++ Y Y+A
Sbjct: 684 PVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 717
>Hs11140811 [D] KOG2167 Cullins
Length = 659
Score = 206 bits (524), Expect = 1e-52
Identities = 193/741 (26%), Positives = 338/741 (45%), Gaps = 100/741 (13%)
Query: 89 IYENLKNYLKDYISN----LKKD--DNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRYWV 142
+Y+ L+ +D++ ++D D+V FL W+ I + +F +++R +V
Sbjct: 2 LYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV 61
Query: 143 QKERS-----DGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQRRGELVNKSA 197
+ + D +F H +++ K V +T + I ++ +R GE V++S
Sbjct: 62 LQNSTLPSIWDMGLELFRTH---IISDKMVQSKT-----IDGILLLIERERSGEAVDRSL 113
Query: 198 ITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIE 257
+ +LG+ +L VY +FE FL++T Y + V EY+
Sbjct: 114 LRS------LLGM------LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLN 161
Query: 258 KANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADK-LKKEFILLLDKQDQRLIKL 316
++ + E +I YLD T PL + + L+ +H L+K LLD+ +
Sbjct: 162 HVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQ 221
Query: 317 IYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPRDYL 376
+Y+L R L+ + YIK G + + +K QD L +D +
Sbjct: 222 MYQLFSRVRGGQQALLQHWSEYIKTFGTAIV--INPEKDKDMVQDL-------LDFKDKV 272
Query: 377 KCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKFATSRAPEMLA 436
+I V CF+ + F + FIN P P E++A
Sbjct: 273 DHVIEV----------CFQKNERFVNLMKESFETFINKR-----PNKPA-------ELIA 310
Query: 437 KYSDQLLKKSTKN--NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLIHGSSKSEA 494
K+ D L+ K +E+++ T+D IM +F+F+ KD FE Y+K+LAKRL+ G S S
Sbjct: 311 KHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVD 370
Query: 495 DEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSAATFRSKVP 554
E+ ++ +L+ E +TSK+ M +D++LSK++ F + + S
Sbjct: 371 AEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSD---------SGPI 421
Query: 555 ELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKWLWPMSRGEIKA 614
+L IL WP +Y P E L P + + + Y KHSGR L+W + +KA
Sbjct: 422 DLTVNILTMGYWP-TYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA 480
Query: 615 HIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQIASNMYPFV--KMK 672
K GK FQ V++FQ +L +FN+ +FE+I+ T ++ +++ + K +
Sbjct: 481 EF-KEGKKEFQ--VSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKAR 537
Query: 673 LLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATVNGSALDETEASE 732
+LI+SP+G E ++ K+ N ++ F +N + ET E
Sbjct: 538 VLIKSPKGKE--VEDGDKFIFNGEFK--------------HKLFRIKINQIQMKET-VEE 580
Query: 733 QKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFNAKVSMIKKAVDN 792
Q + + Q R + A IVRIMK ++ L H+ L++E +Q +F K +KK +++
Sbjct: 581 QVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELY--NQLKFPVKPGDLKKRIES 638
Query: 793 LIEQEYLKR-TDDGECYEYLA 812
LI+++Y++R D+ Y Y+A
Sbjct: 639 LIDRDYMERDKDNPNQYHYVA 659
>7298217 [D] KOG2166 Cullins
Length = 773
Score = 206 bits (523), Expect = 2e-52
Identities = 179/765 (23%), Positives = 326/765 (42%), Gaps = 97/765 (12%)
Query: 86 GGEIYENLKNYLKDYISNLKKDD-----NVTFLNFYVRRWERFTIGAIFLNRVFDYMNRY 140
G +Y L+ + +++ + + D + FL + W + + + YM+R
Sbjct: 68 GNRLYYGLREVVSEHLEHKVRADVLEALHSNFLPKLNQAWTDHQTSMVMIRDILMYMDRV 127
Query: 141 WVQKERSDGKRHIFDAHTLCLMTWKE--VMFETHKTELVTEIFDQLDLQRRGELVNKSAI 198
+VQ+ R + + + L L+ +++ V + + L ++ + +R GE +N AI
Sbjct: 128 YVQQ------REVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAINHLAI 181
Query: 199 TIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEK 258
A + LGI+ + VY ++FE+PFL ++ +Y S FL ++ YI+K
Sbjct: 182 KNACSMLITLGIN-------SRTVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIKK 234
Query: 259 ANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKL----KKEFILLLDKQDQRLI 314
I E LYLD T + + + LI H + + ++ +
Sbjct: 235 VEARITEESSRAALYLDKDTEPRIVRVVEEELIKKHMRPIVEMENSGVVYMIKNSKTEDL 294
Query: 315 KLIYELMKR-DYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPR 373
Y+L R L + DT Y++ G + + + +P
Sbjct: 295 ACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKE---------------EENGNTNPI 339
Query: 374 DYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKFATSRAPE 433
+++ L+ + F + F N F + F+N N+ ++PE
Sbjct: 340 TFVQNLLDLKDRFDQFLVHSFANDRIFKNVISSDFEHFLNLNN-------------KSPE 386
Query: 434 MLAKYSDQLLKKSTK--NNEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLIHGSSK 491
L+ + D LKK K + ++++ +D M +F+FL +KD FE +Y+ +LAKRL+ S
Sbjct: 387 YLSLFIDDKLKKGGKGMSEQEIESILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSV 446
Query: 492 SEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSAATFRS 551
S+ E+ +I +L++E ++TSK+ M +D+ +S + DEF F++ NN S
Sbjct: 447 SDDFEKNMISKLKTECGCQFTSKLEGMFKDMSVSNTIMDEFKNFVN---NNNLSLGGV-- 501
Query: 552 KVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKWLWPMSRGE 611
EL IL WP +P + + + Y +KHSGR L M
Sbjct: 502 ---ELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFYLNKHSGRQLTLQPQMGTAY 558
Query: 612 IKA--------HIGKPGKPPFQ---------------FTVTIFQMAILTLFNDISTLTFE 648
I A K P V+ +QM +L LFN+ LT++
Sbjct: 559 INAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQMCVLLLFNNRDVLTYD 618
Query: 649 QIQERTNLKATQIASNMYPFVKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAA 708
I + T++ P ++ +QS + +L + + K + T +
Sbjct: 619 DIHQETDI----------PERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYVN 668
Query: 709 AVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLM 768
N + A E+K+ ++++ R + A IVRIMKA+++L H+ L+
Sbjct: 669 DAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLV 728
Query: 769 NECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRT-DDGECYEYLA 812
++ ++ + RF IKK ++ LIE+EYL+R+ +D + Y YLA
Sbjct: 729 SDVTSQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 773
>SPAC24H6.03 [D] KOG2166 Cullins
Length = 785
Score = 204 bits (519), Expect = 4e-52
Identities = 204/806 (25%), Positives = 367/806 (45%), Gaps = 91/806 (11%)
Query: 40 QKVLSPRMYMEVYTAIYNYCVNK--SRSTGHFQSDIIGKQMNQSSILVGGEIYENLK-NY 96
QK S + E+Y Y ++K + H Q D+I ++ + ++ IY+N +
Sbjct: 38 QKSTSQLSFEELYRNAYILVLHKYGEKLYNHVQ-DVIRSRLKEETVPA---IYKNYDASL 93
Query: 97 LKDYISNLKKDDNVT------------FLNFYVRRWERFTIGAIFLNRVFDYMNRYWVQK 144
L + + +++K+D+ + FL+ V W+ + ++ V Y+++ V
Sbjct: 94 LGNALLDIRKNDSYSTSWSRSLEAAHRFLSSLVNSWKDHIVSMQMISSVLKYLDK--VYS 151
Query: 145 ERSD----GKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQRRGELVNKSAITI 200
+ +D + I+ + L+ E+ + +T L+ + L+R+G +N+ I
Sbjct: 152 KSADKVPVNENGIYIFREVVLLNSFEIGEKCVETILIL-----VYLERKGNTINRPLIND 206
Query: 201 AIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEKAN 260
+ +L PS+ KK L Y F FL T+ +Y S+ + V EY++KA
Sbjct: 207 CLD---MLNSLPSENKKETL--YDVLFAPKFLSYTRNFYEIESSTVIGVFGVVEYLKKAE 261
Query: 261 ECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKE----FILLLDKQDQRLIKL 316
+ E++ YL + ++PL + + L++ H D L + F ++D + ++L
Sbjct: 262 KRFEEEKERSKNYLFTKIASPLLSVVEDELLSKHLDDLLENQSTGFFSMIDSSNFEGLQL 321
Query: 317 IYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPRDYL 376
+YE R + L Y+ G KLI N++ +Q K G +
Sbjct: 322 VYESFSRVELGVKSLKKYLAKYVAHHG-----KLI---NETTSQALEGKMAVGRLSSNAT 373
Query: 377 KCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKFATSRAPEMLA 436
+ V K+ + ++ R +N+ S A + +RAPE ++
Sbjct: 374 MATLWVQKV-----LALWDRLNTIISTTMDADRSILNSLSDAFVTFVDGY--TRAPEYIS 426
Query: 437 KYSDQLLKKSTKN--NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLIHGSSKSEA 494
+ D LKK + ++ T+ + +T+F+F+++KD FE +Y+ +LAKRL++ S S
Sbjct: 427 LFIDDNLKKDARKAIEGSIEATLQNSVTLFRFISEKDVFEKYYKTHLAKRLLNNRSISSD 486
Query: 495 DEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSAATFRSKVP 554
E +I RL+ E +T K+ M D+ LS+ L E+ SA
Sbjct: 487 AELGMISRLKQEAGNVFTQKLEGMFNDMNLSQELLQEY---------KHNSALQSAKPAL 537
Query: 555 ELEPLILADNVWPFSYQPTEFA--LPPVLEHSKNKLETMYTDKHSGRILKWLWPMSRGEI 612
+L ILA WP P + P VL ++ Y KH+GR L W M ++
Sbjct: 538 DLNVSILASTFWPIDLSPHKIKCNFPKVLLAQIDQFTDFYLSKHTGRKLLWYPSMGSADV 597
Query: 613 KAHIGKPGKPPFQFTVTIFQMAILTLFNDI---STLTFEQIQERTNLKATQIASNMYPF- 668
+ + K K + V+ IL LF D+ L FE+I E+TN++ + N+
Sbjct: 598 RVNF-KDRK--YDLNVSTIASVILLLFQDLKENQCLIFEEILEKTNIEVGDLKRNLQSLA 654
Query: 669 -VKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATVNGSALDE 727
K K+L++ P+G E + K+ N+ + V+ A +K +TV + +++
Sbjct: 655 CAKYKILLKDPKGRE--VNAGDKFYFNENF------VSNLARIK-----ISTVAQTRVED 701
Query: 728 TEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFNAKVSMIK 787
SE+K+ +++++ R ACIVR+MK ++ H+ LM E + RF+ MIK
Sbjct: 702 D--SERKRTLEKVDESRKHQADACIVRVMKDRKVCEHNQLMAEVTRQLNPRFHPSPMMIK 759
Query: 788 KAVDNLIEQEYLKR-TDDGECYEYLA 812
+ ++ LIE+EYL+R D+G YEYLA
Sbjct: 760 RRIEALIEREYLQRQADNGRIYEYLA 785
>At1g43140 [D] KOG2166 Cullins
Length = 711
Score = 202 bits (513), Expect = 2e-51
Identities = 180/818 (22%), Positives = 350/818 (42%), Gaps = 129/818 (15%)
Query: 11 LEATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVNKSRSTGHFQ 70
LE W+ +K G+ ++ I + + P Y+ +YT IY+ C+ + +
Sbjct: 7 LEEGWSVMKTGVAKL------QRILEDLSEPPFDPGQYINLYTIIYDMCLQQPPND---- 56
Query: 71 SDIIGKQMNQSSILVGGEIYENLKNYLKDY-----ISNLKKDDNVTFLNFYVRRWERFTI 125
E+Y + + Y + ++++ L V+RW I
Sbjct: 57 --------------YSQELYNKYRGVVDHYNKETVLPSMRERHGEYMLRELVKRWANHKI 102
Query: 126 GAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQLD 185
+L+R Y++R++V +R + + + ++ +++++ ++E + +
Sbjct: 103 LVRWLSRFCFYLDRFYV------ARRGLPTLNDVGFTSFHDLVYQEIQSEAKDVLLALIH 156
Query: 186 LQRRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNE 245
+R GE ++++ + I + G+ + +Y ++FE LQ T YY++ ++
Sbjct: 157 KEREGEQIDRTLVKNVIDVYCGNGVG-------QMVIYEEDFESFLLQDTASYYSRKASR 209
Query: 246 FLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTAL-NQVLIADHADKLKKEF-- 302
+ S +Y+ KA EC+ E++ + YL S T L + N++L+ ++ E
Sbjct: 210 WSQEDSCPDYMLKAEECLKLEKERVTNYLHSTTEPKLVEKVQNELLVVVAKQLIENEHSG 269
Query: 303 -ILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQD 361
+ LL + +Y L + + L + D F ++ GN I + DA A
Sbjct: 270 CLALLRDDKMGDLSRMYRLYRLIPQGLEPIADLFKQHVTAEGNALIKQAADAATNQDASA 329
Query: 362 SNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPP 421
S + + D Y ++ + ECF+ H F K L F N
Sbjct: 330 SQVLVRKEIELHDK-------YMVYVD---ECFQKHSLFHKLLKEAFEVFCNKT------ 373
Query: 422 GSPKFATSRAPEMLAKYSDQLLK----KSTKNNEQVDLTVDDIMTVFKFLADKDAFEMHY 477
A + + E+LA Y D +LK ++E ++T++ ++ + +++DKD F Y
Sbjct: 374 ----VAGASSAEILATYCDNILKTRGGSEKLSDEATEITLEKVVNLLVYISDKDLFAEFY 429
Query: 478 RKNLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFIS 537
RK A+RL+ S I K + D+ L++ L F ++S
Sbjct: 430 RKKQARRLLFDRSG-----------------------IMKEVTDITLARELQTNFVDYLS 466
Query: 538 QDGNNTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHS 597
N TT + +L WP SY+ T+ LP + + + Y K +
Sbjct: 467 --ANMTTKLGI------DFTVTVLTTGFWP-SYKTTDLNLPTEMVNCVEAFKVFYGTKTN 517
Query: 598 GRILKWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLK 657
R L W++ + I +GK K + V+ +Q A+L LFN+ L++ +I E+ NL
Sbjct: 518 SRRLSWIYSLGTCHI---LGKFEKKTMELVVSTYQAAVLLLFNNAERLSYTEISEQLNLS 574
Query: 658 ATQIASNMYPF--VKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLT 715
+ ++ +K K+LI+ P ++ K DT +K
Sbjct: 575 HEDLVRLLHSLSCLKYKILIKEPMS-RTISKTDTFEFNSK-------------------- 613
Query: 716 FTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAES 775
FT + + E+KK +++++ R + A +VRIMK+++ L H L++EC+
Sbjct: 614 FTDKMRKIRVPLPPMDERKKVVEDVDKDRRYAIDAALVRIMKSRKVLAHQQLVSECVEHL 673
Query: 776 QQRFNAKVSMIKKAVDNLIEQEYLKR-TDDGECYEYLA 812
+ F + MIKK +++LI ++YL+R T++ ++Y+A
Sbjct: 674 SKMFKPDIKMIKKRIEDLINRDYLERDTENANTFKYVA 711
>7301740 [O] KOG2285 E3 ubiquitin ligase Cullin 1 component
Length = 852
Score = 198 bits (503), Expect = 3e-50
Identities = 168/671 (25%), Positives = 307/671 (45%), Gaps = 68/671 (10%)
Query: 159 LCLMTWKEVMFETHKTELVTEIFDQLDLQRRGELVNKSAITIAIKSFVILGIDPSDLKKL 218
L L +W + +F K L + +R G+ + + +S+V L + D
Sbjct: 216 LMLDSWNKHIFHDIKHRLQESAMKIVHAERNGDAYDAQLVVGVRESYVNLSSNAED---- 271
Query: 219 NLNVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHT 278
L +Y +NFE +L+ T E+Y S E + V Y++ A+ + EE YL+ +
Sbjct: 272 KLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLAYMKYADSKLREEEVRAKRYLEPSS 331
Query: 279 SAPLSTALNQVLIADHADKLKKEFILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMY 338
+ L+ L VLI DH + + E L+ + + L++ LM D
Sbjct: 332 FSILTYTLVNVLIVDHLNSIIAECPALIRDYETERLNLMFRLM--------------DRV 377
Query: 339 IKRVGNEEIDKLIDAHNKSA--AQDSNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFEN 396
+ VG E + + H SA A +A Y++ L+ ++ F ++ F +
Sbjct: 378 MHGVGVEPMMGDLQRHIMSAGLADMLSASEVITQDSEKYVERLLELFNKFSDLVRNAFND 437
Query: 397 HPAFAKALDYGCRCFINNNSF-------AIPPGSPKFAT--SRAPEMLAKYSDQLLKKST 447
P F A D + +N+ S +I K+ S+ PE+LA Y D LL+++
Sbjct: 438 DPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVKYTAPESKCPELLANYCDMLLRRTP 497
Query: 448 KN----NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLIHGSSKSEADEEIIIQRL 503
+ +EQ+D + D++ V K++ +KD F +++ +L +RLI G+S EE I++ L
Sbjct: 498 LSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEEDIVEWL 557
Query: 504 QSEN-SLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSAATFRSKVPELEPLILA 562
+ +Y +++ +M QD+K+S++L+ +F T IS+ + IL
Sbjct: 558 REVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRH--------------DAINIKILN 603
Query: 563 DNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKWLWPMSRGEIKAHIGKPGKP 622
W + +LP LE +E Y KHSGR L+W MS G I + G+
Sbjct: 604 AGAWARCSERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTI-TFVNNFGR- 661
Query: 623 PFQFTVTIFQMAILTLFN--DISTLTFEQIQERTNLKATQIASNM-----YPFVKMKLLI 675
+ VT FQMA+L +N +++E ++ T L ++ + +P +K ++L+
Sbjct: 662 -YDLDVTTFQMAVLFAWNQRQHDKISYENLRLATELPDPELRRTLWSLVAFPKIKKQILL 720
Query: 676 QSPEGVESM--IKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATVNGSALDETEASEQ 733
P + S +T + +N+ + + K K+ + G TE S+Q
Sbjct: 721 MEPAAISSPKDFAENTMFYINQEFAIVKNG-------KSQRRGKLNLIGRLQLSTERSQQ 773
Query: 734 KKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFNAKVSMIKKAVDNL 793
+ + + Q R++ + I++IMK ++++ +++L E I + F MIK+ ++ L
Sbjct: 774 ED-NQSIVQLRILRTQEAIIKIMKVRKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWL 832
Query: 794 IEQEYLKRTDD 804
IE +Y++R DD
Sbjct: 833 IENKYMRRDDD 843
>Hs4503167 [O] KOG2285 E3 ubiquitin ligase Cullin 1 component
Length = 780
Score = 191 bits (484), Expect = 5e-48
Identities = 174/760 (22%), Positives = 340/760 (43%), Gaps = 74/760 (9%)
Query: 88 EIYENLKNYLKDYISN-----LKKDDNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRYWV 142
+I++ LK + ++I L D+ L Y+ W +F L + F + +
Sbjct: 60 KIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLM 119
Query: 143 QKERSDGKRHIFDA--HTLCLMTWKEVMFETHKTELVTEIFDQLDLQRRGELVNKSAITI 200
K+ S+ K ++ D+ L L TW E +F K L + +R GE + +
Sbjct: 120 GKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIG 179
Query: 201 AIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEKAN 260
+S+V L +P D L +Y NFE+ +L T+ +Y + +L + V Y++ A+
Sbjct: 180 VRESYVNLCSNPED----KLQIYRDNFEKAYLDSTERFYRTQAPSYLQPNGVQNYMKYAD 235
Query: 261 ECIIFEEKDMILYLDSHTSAPLSTALNQ----VLIADHADKLKKEFILLLDKQDQRLIKL 316
+ EEK + YL++ AL + L+ + + E ++ + + + L
Sbjct: 236 AKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHL 295
Query: 317 IYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPRDYL 376
++ LM + + ++ + +I G ++ A ++ DS Y+
Sbjct: 296 MFSLMDKVPNGIEPMLKDLEEHIISAGLADMV----AAAETITTDSEK----------YV 341
Query: 377 KCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSF---AIP-----PGSPKFAT 428
+ L+ ++ F + E F++ P F A D + +N+ + +P G
Sbjct: 342 EQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPE 401
Query: 429 SRAPEMLAKYSDQLLKKSTKN----NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKR 484
S+ PE+LA Y D LL+K+ + +E+++ + +++ V K++ +KD F +++ +L +R
Sbjct: 402 SKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRR 461
Query: 485 LIHGSSKSEADEEIIIQRLQSENS-LEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNT 543
LI S EE +++ L+ +Y +K+ +M QD+K+S++L+ F NN
Sbjct: 462 LILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFK---EMHKNNK 518
Query: 544 TSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKW 603
+ + IL W S + +LP LE ++E Y HSGR L W
Sbjct: 519 LALPADSVNIK-----ILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHW 573
Query: 604 LWPMSRGEI--KAHIGKPGKPPFQFTVTIFQMAILTLFNDI--STLTFEQIQERTNLKAT 659
MS G I K +G+ + VT FQ+A+L +N ++FE ++ T L
Sbjct: 574 HHLMSNGIITFKNEVGQ-----YDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDA 628
Query: 660 QIASNM-----YPFVKMKLLIQSPE-GVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKND 713
++ + +P +K ++ + P+ T +++N+ + L K + K
Sbjct: 629 ELRRTLWSLVAFPKLKRQVFLYDPQVNSPKDFTEGTLFSVNQEFSLIKNA-------KVQ 681
Query: 714 LTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIA 773
+ G TE +++ E + Q R++ + I++IMK ++K+ ++ L E +
Sbjct: 682 KRGKINLIGRLQLTTERMREEENEG-IVQLRILRTQEAIIQIMKMRKKISNAQLQTELVE 740
Query: 774 ESQQRFNAKVSMIKKAVDNLIEQEYLKRTD-DGECYEYLA 812
+ F + MIK+ ++ LIE +Y++R + D + Y+A
Sbjct: 741 ILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780
>At5g46210 [D] KOG2167 Cullins
Length = 617
Score = 188 bits (477), Expect = 3e-47
Identities = 161/648 (24%), Positives = 302/648 (45%), Gaps = 90/648 (13%)
Query: 177 VTEIFDQLDLQRRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTK 236
V + ++ +R E VN++ ++ +K F LGI Y+++FE+PFL+ T
Sbjct: 48 VKGLLSMIEKERLAEAVNRTLLSHLLKMFTALGI------------YMESFEKPFLEGTS 95
Query: 237 EYYTKMSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHA- 295
E+Y +++ V EY++ + E + ILY+D+ T PL T + + L+ H
Sbjct: 96 EFYAAEGMKYMQQSDVPEYLKHVEGRLHEENERCILYIDAVTRKPLITTVERQLLERHIL 155
Query: 296 DKLKKEFILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHN 355
L+K F L+D + ++ + L R L L Y+++ G K++
Sbjct: 156 VVLEKGFTTLMDGRRTEDLQRMQTLFSR-VNALESLRQALSSYVRKTGQ----KIVMDEE 210
Query: 356 KSAAQDSNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNN 415
K +D ++ L+ I E F + +F + IN
Sbjct: 211 KD---------------KDMVQSLLDFKASLDIIWEESFYKNESFGNTIKDSFEHLIN-- 253
Query: 416 SFAIPPGSPKFATSRAPEMLAKYSDQLLKKSTK--NNEQVDLTVDDIMTVFKFLADKDAF 473
+R E++AK+ D+ L+ K + E+++ ++ ++ +F+F+ KD F
Sbjct: 254 ----------LRQNRPAELIAKFLDEKLRAGNKGTSEEELESVLEKVLVLFRFIQGKDVF 303
Query: 474 EMHYRKNLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFS 533
E Y+K+LAKRL+ G S S E+ +I +L++E ++T+K+ M +D++LSK +++ F
Sbjct: 304 EAFYKKDLAKRLLLGKSASIDAEKSMISKLKTECGSQFTNKLEGMFKDIELSKEINESFK 363
Query: 534 TFISQDGNNTTSAATFRSKVP---ELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLET 590
++ R+K+P E+ +L WP +Y P + LP L ++ +
Sbjct: 364 -----------QSSQARTKLPSGIEMSVHVLTTGYWP-TYPPMDVKLPHELNVYQDIFKE 411
Query: 591 MYTDKHSGRILKWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFND---ISTLTF 647
Y K+SGR L W + +KA K K + V++FQ++ + S L+
Sbjct: 412 FYLSKYSGRRLMWQNSLGHCVLKADFSKGKK---ELAVSLFQVSQIFFPPPPLLSSFLSS 468
Query: 648 EQIQERTNLKATQIASNMYPFV--KMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVN 705
I++ T+++ ++ + K+++L ++P+G + ++ ++ N
Sbjct: 469 RDIKDSTSIEDKELRRTLQSLACGKVRVLQKNPKGRD--VEDGDEFEFND---------E 517
Query: 706 FAAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHS 765
FAA + + VN + ET E + + Q R + A IVRIMK ++ L H+
Sbjct: 518 FAAPL-----YRIKVNAIQMKET-VEENTSTTERVFQDRQYQIDAAIVRIMKTRKVLSHT 571
Query: 766 SLMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKR-TDDGECYEYLA 812
L+ E Q +F K + +KK +++LI++EYL+R + + Y YLA
Sbjct: 572 LLITELF--QQLKFPIKPADLKKRIESLIDREYLEREKSNPQIYNYLA 617
>CE27593 [D] KOG2166 Cullins
Length = 777
Score = 187 bits (475), Expect = 6e-47
Identities = 170/775 (21%), Positives = 339/775 (42%), Gaps = 112/775 (14%)
Query: 86 GGEIYENLKNYLKDYISNLK-----KDDNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRY 140
G +Y LK+ ++D++++++ ++ +FL W T+ + + + YM+R
Sbjct: 67 GERLYNGLKDVIQDHMASVRIRIIESMNSGSFLETVAESWADHTVAMVMIRDILMYMDRI 126
Query: 141 WVQKERSDGKRHIFDAHTLCLMTWK-EVMFETHKTELVTE-IFDQLDLQRRGELVNKSAI 198
+V + H+ + L L ++ E++ + + + + + + + L R+ +N I
Sbjct: 127 YVAQNN-----HVLPVYNLGLDAYRTEILRQNGIGDRIRDALLELIKLDRKSNQINWHGI 181
Query: 199 TIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDS-HSVSEYIE 257
A + LGID + VY FE+P L++T +YY + +L + Y+
Sbjct: 182 KNACDMLISLGID-------SRTVYEDEFERPLLKETSDYYRDVCKNWLSGDNDACFYLA 234
Query: 258 KANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKEFILLLDKQDQRLIKLI 317
+ + E YLD T A + ++ V++A+H I + +K +
Sbjct: 235 QVEIAMHDEASRASRYLDKMTEAKILQVMDDVMVAEH--------IQTIVYMQNGGVKFM 286
Query: 318 YELMKRDYRMLPDLVDTFDMYIKRVGNEE------IDKLIDAHNKSAAQD-SNAKRQPGL 370
E ++ + DL F ++ KR+G+ + L+ A ++ + SN + L
Sbjct: 287 LE-----HKKIEDLTRIFRIF-KRIGDSVTVPGGGLKALLKAVSEYLNETGSNIVKNEDL 340
Query: 371 --SPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKFAT 428
+P +++ L+ + F ++ F + F + F+N+N
Sbjct: 341 LKNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLNSNR------------ 388
Query: 429 SRAPEMLAKYSDQLLKKSTK--NNEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLI 486
++PE +A Y D +L+ K ++ ++D +D++M +F++L +KD FE ++++ LAKRL+
Sbjct: 389 -QSPEFVALYMDDMLRSGLKCVSDAEMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLL 447
Query: 487 HGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSA 546
S S+ E+ ++ +L++E ++T K+ M +D +L L F + +
Sbjct: 448 LDKSCSDDVEKALLAKLKTECGCQFTQKLENMFRDKELWLTLATSFRDWREAQPTKMSID 507
Query: 547 ATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKWLWP 606
+ R +L VWP + Q LP L + YT+KH+GR L
Sbjct: 508 ISLR---------VLTAGVWP-TVQCNPVVLPQELSVAYEMFTQYYTEKHTGRKLTINTL 557
Query: 607 MSRGEIKAHIGKPGKPPFQ------------------------FTVTIFQMAILTLFNDI 642
+ ++KA P K V QM IL FN
Sbjct: 558 LGNADVKATFYPPPKASMSNEENGPGPSSSGESMKERKPEHKILQVNTHQMIILLQFNHH 617
Query: 643 STLTFEQIQERTNLKATQIASNMYPF----VKMKLLIQSPEGVESMIKLDTKYTLNKPYR 698
+ ++ +Q+ + + ++ N+ ++L++ +G ++ I + ++ +N ++
Sbjct: 618 NRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNKGKDA-IDMSDEFAVNDNFQ 676
Query: 699 LSKTSVNFAAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKA 758
T V V G E E E + +++ R + + A IVRIMKA
Sbjct: 677 SKLTRVK-----------VQMVTGKVESEPEIRETR---QKVEDDRKLEVEAAIVRIMKA 722
Query: 759 KRKLPHSSLMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRTD-DGECYEYLA 812
++KL H++L+ E + + RF +IK+ ++ LIE+EYL R + D Y+Y+A
Sbjct: 723 RKKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777
>At4g02570 [D] KOG2166 Cullins
Length = 676
Score = 182 bits (461), Expect = 2e-45
Identities = 177/814 (21%), Positives = 342/814 (41%), Gaps = 155/814 (19%)
Query: 10 DLEATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVNKSRSTGHF 69
DLE W++++ GI ++ I + YM +YT IYN C K H
Sbjct: 7 DLEQGWDYMQTGITKL------KRILEGLNEPAFDSEQYMMLYTTIYNMCTQKPP---HD 57
Query: 70 QSDIIGKQMNQSSILVGGEIYENLKNYLKDYISN-----LKKDDNVTFLNFYVRRWERFT 124
S ++Y+ + ++YI++ L++ + L +RW
Sbjct: 58 YSQ---------------QLYDKYREAFEEYINSTVLPALREKHDEFMLRELFKRWSNHK 102
Query: 125 IGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQL 184
+ +L+R F Y++RY++ +R + + + L ++ D +
Sbjct: 103 VMVRWLSRFFYYLDRYFI------ARRSLPPLNEVGLTCFR----------------DLV 140
Query: 185 DLQRRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSN 244
D +R GE ++++ L K L++Y + L+K +E
Sbjct: 141 DKEREGEQIDRA------------------LLKNVLDIY----SEECLKKERERVA---- 174
Query: 245 EFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADKLKKEFIL 304
+L S S + +EK + ++++ S + +L D D L +
Sbjct: 175 HYLHSSSEPKLVEKV-------QHELLVVFASQLLEKEHSGCRALLRDDKVDDLSR---- 223
Query: 305 LLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNA 364
+Y L + R L + + F ++ GN + + D A ++
Sbjct: 224 ------------MYRLYHKILRGLEPVANIFKQHVTAEGNALVQQAEDTATNQVANTASV 271
Query: 365 KRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSP 424
+ Q ++ +I ++ + ECF+NH F KAL F N
Sbjct: 272 QEQV------LIRKVIELHDKYMVYVTECFQNHTLFHKALKEAFEIFCNKT--------- 316
Query: 425 KFATSRAPEMLAKYSDQLLKKSTK---NNEQVDLTVDDIMTVFKFLADKDAFEMHYRKNL 481
A S + E+LA + D +LKK ++E ++ T++ ++ + +++DKD F YRK L
Sbjct: 317 -VAGSSSAELLATFCDNILKKGGSEKLSDEAIEDTLEKVVKLLAYISDKDLFAEFYRKKL 375
Query: 482 AKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGN 541
A+RL+ S ++ E I+ +L+ + ++TSK+ M+ D+ L++ + F ++ G+
Sbjct: 376 ARRLLFDRSANDDHERSILTKLKQQCGGQFTSKMEGMVTDLTLARENQNSFEDYL---GS 432
Query: 542 NTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRIL 601
N + +L +L WP SY+ + LP + + Y K R L
Sbjct: 433 NPAANPGI-----DLTVTVLTTGFWP-SYKSFDINLPSEMIKCVEVFKGFYETKTKHRKL 486
Query: 602 KWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQI 661
W++ + I GK + + V+ +Q A+L LFN L++ +I + NL +
Sbjct: 487 TWIYSLGTCHIN---GKFDQKAIELIVSTYQAAVLLLFNTTDKLSYTEILAQLNLSHEDL 543
Query: 662 ASNMYPF--VKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTAT 719
++ K K+L++ P +TK +V+ A + + FT
Sbjct: 544 VRLLHSLSCAKYKILLKEP---------NTK------------TVSQNDAFEFNSKFTDR 582
Query: 720 VNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRF 779
+ + E+KK +++++ R + A IVRIMK+++ L H L++EC+ + + F
Sbjct: 583 MRRIKIPLPPVDERKKVVEDVDKDRRYAIDAAIVRIMKSRKVLGHQQLVSECVEQLSRMF 642
Query: 780 NAKVSMIKKAVDNLIEQEYLKR-TDDGECYEYLA 812
+ IKK +++LI ++YL+R ++ + YLA
Sbjct: 643 KPDIKAIKKRMEDLITRDYLERDKENPNMFRYLA 676
>At1g02980 [D] KOG2166 Cullins
Length = 648
Score = 169 bits (428), Expect = 2e-41
Identities = 135/513 (26%), Positives = 234/513 (45%), Gaps = 56/513 (10%)
Query: 307 DKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKR 366
DK D + +Y L + L + D F +I G+ I + +A AA S K
Sbjct: 185 DKMDD--LARMYRLYHPIPQGLDPVADLFKQHITVEGSALIKQATEAATDKAASTSGLKV 242
Query: 367 QPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKF 426
Q + R LI ++ F ECF+ H F KAL F N +
Sbjct: 243 QDQVLIRQ----LIDLHDKFMVYVDECFQKHSLFHKALKEAFEVFCNKTVAGVS------ 292
Query: 427 ATSRAPEMLAKYSDQLLKKS----TKNNEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLA 482
+ E+LA Y D +LK NE ++LT++ ++ + +++DKD F +RK A
Sbjct: 293 ----SAEILATYCDNILKTGGGIEKLENEDLELTLEKVVKLLVYISDKDLFAEFFRKKQA 348
Query: 483 KRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNN 542
+RL+ + ++ E ++ + + ++TSK+ ML D+ L+K F F+S N
Sbjct: 349 RRLLFDRNGNDYHERSLLTKFKELLGAQFTSKMEGMLTDMTLAKEHQTNFVEFLSV--NK 406
Query: 543 TTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILK 602
T + +L WP SY+ T+ LP + + + Y K + R L
Sbjct: 407 TKKLGM------DFTVTVLTTGFWP-SYKTTDLNLPIEMVNCVEAFKAYYGTKTNSRRLS 459
Query: 603 WLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQIA 662
W++ + ++ GK K + VT +Q A+L LFN+ L++ +I E+ NL +A
Sbjct: 460 WIYSLGTCQLA---GKFDKKTIEIVVTTYQAAVLLLFNNTERLSYTEILEQLNLGHEDLA 516
Query: 663 SNMYPF--VKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATV 720
++ +K K+LI+ P ++ DT +K FT +
Sbjct: 517 RLLHSLSCLKYKILIKEPMS-RNISNTDTFEFNSK--------------------FTDKM 555
Query: 721 NGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFN 780
+ E+KK +++++ R + A +VRIMK+++ L H L++EC+ + F
Sbjct: 556 RRIRVPLPPMDERKKIVEDVDKDRRYAIDAALVRIMKSRKVLGHQQLVSECVEHLSKMFK 615
Query: 781 AKVSMIKKAVDNLIEQEYLKR-TDDGECYEYLA 812
+ MIKK +++LI ++YL+R TD+ ++YLA
Sbjct: 616 PDIKMIKKRIEDLISRDYLERDTDNPNTFKYLA 648
>7304097 [D] KOG2167 Cullins
Length = 773
Score = 164 bits (414), Expect = 7e-40
Identities = 177/749 (23%), Positives = 315/749 (41%), Gaps = 130/749 (17%)
Query: 78 MNQSSILVGGEIYENLKNYLKDYIS-NLKKD-------DNVTFLNFYVRRWERFTIGAIF 129
+N S + ++Y LK + ++ N+K D + L W F I
Sbjct: 141 VNMCSHKMDAQLYAKLKELTEQHVKRNIKLKELTGGSMDKLILLEKINHWWLSFCQQMIM 200
Query: 130 LNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQRR 189
+ +F YM+R +V + + I+D L L + V + ++ +R+
Sbjct: 201 IRSIFLYMDRTYVLQNST--VHSIWDMG-LDLFRIHFAQNSVVQKRTVDGLLTLIEKERQ 257
Query: 190 GELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDS 249
G V++ + KS V + D L +Y +FE+ FL T + Y S +
Sbjct: 258 GSTVDRGLL----KSLVRMLCD--------LQIYTSSFEEKFLDATNQLYKAESQRKMQE 305
Query: 250 HSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTALNQVLIADHADK-LKKEFILLLDK 308
V EY++ N+ + E + + YLDS T PL + + L+A+H L+K LL+
Sbjct: 306 LEVPEYLQHVNKRLAEENERLRHYLDSSTKHPLIYNVEKELLAEHLTSILQKGLDSLLED 365
Query: 309 QDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQP 368
+ L+Y L+ R +L F+ +IK+ G + + +KS QD
Sbjct: 366 NRLSDLTLLYGLLSRVKNGTSELCGNFNGFIKKKGRTIV--IDPEKDKSMVQDL------ 417
Query: 369 GLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNSFAIPPGSPKFAT 428
L +D + ++ CFE++ F +L FIN +
Sbjct: 418 -LDFKDKMDVIVRT----------CFEHNEKFTNSLREAFEFFINQRA------------ 454
Query: 429 SRAPEMLAKYSDQLLKKSTK--NNEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLI 486
++ E++AKY D L+ K +E+++ T+D IM +LAKRL+
Sbjct: 455 NKPAELIAKYVDMKLRSGNKGTTDEELEKTLDKIM------------------DLAKRLL 496
Query: 487 HGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSA 546
G S S E+ ++ +L+ E +TSK+ M +D++LS++++ F + + +
Sbjct: 497 VGKSASVDSEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINIAFRGHALSNNRDVHNL 556
Query: 547 ATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKWLWP 606
+L IL WP +Y PTE +PP + + Y +KHSGR L+W
Sbjct: 557 --------DLCVSILTMGYWP-TYAPTEVTMPPQFINPQQIFNKFYLEKHSGRKLQWQPT 607
Query: 607 MSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQIASNMY 666
+ ++A P L++E+I T ++ ++ +
Sbjct: 608 LGNCMLRAQFDAP------------------------VLSYEEILAATLIEDGELRRTLQ 643
Query: 667 PFV--KMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATVNGSA 724
+ +++ ++P+G E L +F N L F +N
Sbjct: 644 SLACGRARVITKTPKGREI---------------LDGDQFDFNNEFTNKL-FRIKINQIQ 687
Query: 725 LDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFNAKVS 784
+ ET EQK E+ + Q R + A IVRIMK ++ L H+ L+ E +Q F K +
Sbjct: 688 MKETN-EEQKATEERVFQDRQYQIDAAIVRIMKMRKTLSHNLLITELF--NQLTFPVKPA 744
Query: 785 MIKKAVDNLIEQEYLKRTDDGE-CYEYLA 812
+KK +++LI+++Y++R D + Y Y+A
Sbjct: 745 DLKKRIESLIDRDYMERDKDNQNQYNYVA 773
>CE06658 [O] KOG2285 E3 ubiquitin ligase Cullin 1 component
Length = 741
Score = 162 bits (409), Expect = 3e-39
Identities = 177/760 (23%), Positives = 323/760 (42%), Gaps = 101/760 (13%)
Query: 88 EIYENLKNYLKDYISNLKK-----DDNVTFLNFYVRRWERFTIGAIFLNRVFDYMNRYWV 142
+I + L + DY+ K + + L Y++ W RF A L F ++
Sbjct: 48 KIRDILTRCINDYVHEANKRIRSLQTDGSLLIGYIKEWNRFYQQANILPLPFKKIDES-- 105
Query: 143 QKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFDQLDLQRRGELVNKSAITIAI 202
+ RS + T+ L W E++F +L+ E + +R G +++ +
Sbjct: 106 SRRRSVPETPEESIRTVMLEKWNEIIFMNISEQLLVEALRLVKEERDGNIIDAQNVIGIR 165
Query: 203 KSFVIL----GIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEK 258
+SFV L G DP L VY Q+FE+ F+++T EYY K+ L+ V EY+
Sbjct: 166 ESFVALNDRAGEDP-------LLVYRQSFERQFIEQTTEYYKKICGNLLNELGVLEYMVY 218
Query: 259 ANECIIFEEKDMILYLD--SHTSAPLSTALNQVLIADHADKLKKEFILLLDKQDQRLIKL 316
A++ + E++ YL+ S TS L+ D + E L+ +D ++
Sbjct: 219 ADKKLEEEQQRAKRYLEMNSPTSGKHMEKAVIALVESFEDTILAECSKLIASKDVERLQR 278
Query: 317 IYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLS--PRD 374
+Y L++R R G + + K ID H ++ + LS P
Sbjct: 279 LYRLIRR----------------TRSGIDTVLKCIDTHIRTEGLNDMRNNAENLSTDPER 322
Query: 375 YLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFINNNS-----FAIPPGSPKFATS 429
Y++ L+ ++ F ++ E F + A D R +N++S G S
Sbjct: 323 YVQQLLLMFDKFSSLVREGFCDDARLLTARDKAFRAVVNDSSIFKTEMMNKKGRTLSVES 382
Query: 430 RAPEMLAKYSDQLLKKSTKN----NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRL 485
+ E+LA Y D LL+K+ + +E++D ++ ++ V K++ +KD F +R +L++RL
Sbjct: 383 KCAELLANYCDLLLRKTQLSKKLTSEEIDEKLNQVLLVLKYVENKDVFMRFHRAHLSRRL 442
Query: 486 IHGSSKSEADEEIIIQRL-QSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTT 544
I S + EE+++ +L + + +K+++MLQD++L+K+++ F ++ NN +
Sbjct: 443 ILEMSADQEKEEMMVTKLRECGMPSDAVNKLSRMLQDIELNKDMNSSFKKALTGTNNNKS 502
Query: 545 SAATFRSKVPELEPLILADNVW-PFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKW 603
A + KV L W + F+LP LE E ++ + GR
Sbjct: 503 IADSINMKV-------LNGGAWGRGGSERIRFSLPRELEDFVP--EMVFGTANGGR---- 549
Query: 604 LWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFND-------ISTLTFEQIQERTNL 656
F T FQMA+L FND + TL L
Sbjct: 550 --------------------FDLECTTFQMAVLFCFNDRAHDKISLETLRLATELPDAEL 589
Query: 657 KATQIASNMYPFVKMKLL---IQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKND 713
T ++ YP ++ ++L + S TK+ +N + + K K+
Sbjct: 590 NRTLLSLVAYPKMRYQILLCDVPSTTVTARDFTDSTKFLINHDFNVVKNG-------KSQ 642
Query: 714 LTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIA 773
+ G EA+ +K+ E + + L ++ IV+I+K ++ + L E +
Sbjct: 643 QRGKVNLIGRLQLSLEANAEKEHESIVALRELR-VQEGIVKILKTRKTYTLAQLTMELVE 701
Query: 774 ESQQRFNAKVSMIKKAVDNLIEQEYL-KRTDDGECYEYLA 812
+ F +IK+ +D LIE +Y+ +R DD + Y++
Sbjct: 702 ILKPLFIPNRKIIKEQIDWLIENKYMERRADDINTFVYIS 741
>YGR003w [D] KOG2166 Cullins
Length = 744
Score = 148 bits (374), Expect = 3e-35
Identities = 190/834 (22%), Positives = 348/834 (40%), Gaps = 139/834 (16%)
Query: 9 DDLEATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVNKSRSTGH 68
+ E +W VK ID I D ++ + +VY IY +NK
Sbjct: 20 ESFEESWETVKYAIDHIYSDD-------------MADLSFEQVYKTIYTIVLNKK----- 61
Query: 69 FQSDIIGKQMNQSSILVGGEIYENLKNYLKDYISNLKKD---DNV---TFLNFYVRRWER 122
G +Y LK+YL ++ L++ DN FL R WE
Sbjct: 62 -----------------GPILYNRLKDYLIQKLALLRETIVKDNTHDYEFLGTMARLWEV 104
Query: 123 FTIGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEIFD 182
+ YM++ + + R + + +CL ++ + + + L++ +
Sbjct: 105 QCHCFKITGDLMMYMDKVYCKPNRC------MEVYDMCLDLFRIEILQKCSSSLISALIS 158
Query: 183 QLDLQRRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYTKM 242
++ R V+ ++ V++G+ + L + ++ +FE + T+EYY K
Sbjct: 159 DIERIRNLGSVDSEHTSLWK---VLIGMMET-LHDNRDSFFLTDFEPVLISATEEYYNKA 214
Query: 243 SNEFLDSHSVSEYIEKANECIIFEEK--DMILYLDSHTSAPLSTALNQVLI----ADHAD 296
+ ++ + E +EK + FE L +DSH L T L VLI +D +
Sbjct: 215 ID--IELLTPIESLEKIRKLRQFESMLDSSFLNVDSHNK--LKTVLENVLIWGKLSDIIE 270
Query: 297 KLKKEFILLLDKQDQRLIKLIYELMKRD-YRMLPDLVDTFDMYIKRVGNEEIDKLIDAHN 355
L E +++ + +L++ IY+L + YR+ ++++ YI + +A N
Sbjct: 271 DLTHEAMVI---SNGKLLQEIYDLSSEEKYRVT--VIESIKSYINK----------NAIN 315
Query: 356 KSAAQDSNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKALDYGCRCFIN-- 413
+ + K Q ++ + + +E + + +F +++D+G N
Sbjct: 316 IPFNEGNRKKGQNAIT--------------WSSEIVELYRSQHSFLESIDFGSVRLNNLT 361
Query: 414 ---NNSFAIPPGSPKFATSRA--PEMLAKYSDQLLKKSTKNNEQVDLTVDDIMTVFKF-- 466
+N+ S F+ A E L+ Y D +K++ + + ++ D++ K
Sbjct: 362 GDVSNAILGDVFSMYFSKEGALPSEYLSTYVDHCMKRTKEKDAEIVKIKQDLLDSTKLIG 421
Query: 467 -LADKDAFEMHYRKNLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLS 525
L +KD FE Y+K L++RL+ S E E+ ++Q ++ +TSK+ ML+D+ LS
Sbjct: 422 LLTEKDIFEKIYKKQLSRRLLQQRSLVEI-EKWMVQMIKKVLGTFFTSKLEIMLRDISLS 480
Query: 526 KNLHDEFSTFISQDGNNTTSAATFRSKVPELEPLILADNVWPF-SYQPTE--FALPPVLE 582
++ F ++T ++ + S P+ +L WPF S P + +LPP +
Sbjct: 481 SEMYQAFQ-------HSTINSIEYLSFAPQ----VLTRTSWPFQSTNPIDEGISLPPRMS 529
Query: 583 HSKNKLETMYTDKHSGRILKWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDI 642
E Y+ K+ R+LKW +S EI ++ + +++ I LF D
Sbjct: 530 QILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQFNSGY---YEISFSVYAGVIFLLFEDY 586
Query: 643 STLTFEQIQERTNLKATQIAS---NMYPFVKMKLLIQSPEGVESMIKLDTKYTLNKPYRL 699
LT +I E T++ + S +M + K+L +S +K Y + P R
Sbjct: 587 EELTLGEIYELTHIPIDDVKSLVMSMSTIPRCKILKKSSSS--GNMKFSVNYFFSSPNRK 644
Query: 700 SKTSVNFAAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAK 759
K V AT AS + E+ +M L A IVRIMK +
Sbjct: 645 VKVPVIACPLPSQKSDNLAT----------ASSVDTYDNEI----VMELSAIIVRIMKTE 690
Query: 760 RKLPHSSLMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKR-TDDGECYEYLA 812
KL H L+ +Q R + S++K+++ LIE+EY++R DD Y YL+
Sbjct: 691 GKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYYHYLS 744
>SPAC3A11.08 [D] KOG2167 Cullins
Length = 734
Score = 144 bits (363), Expect = 5e-34
Identities = 133/601 (22%), Positives = 256/601 (42%), Gaps = 76/601 (12%)
Query: 222 VYIQNFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAP 281
+Y F +L +Y S++ + + EY+E A + E+ + +
Sbjct: 198 MYSSVFVPMYLVMLSRFYDTESSQKIQELPLEEYLEYAMSSLEREDAYVEKFDIVRDKKS 257
Query: 282 LSTALNQVLIADHADKLKKEFILLLDKQDQRLIKLIYELMK----RDYRMLPDLVDTFDM 337
+ + + LI H D L K ++K+D KL+Y L++ +Y + P D+
Sbjct: 258 IRETVQRCLITSHLDTLTKGISQFIEKRDAHSCKLLYALLQFNHETEYLIQPWSDCLVDV 317
Query: 338 YIKRVGNEEIDKLIDAHNKSAAQDSNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENH 397
K V +E D + ++ L+ +K + E F +
Sbjct: 318 GFKLVNDESKDDTL------------------------VQELLSFHKFLQVVVDESFLHD 353
Query: 398 PAFAKALDYGCRCFINNNSFAIPPGSPKFATSRAPEMLAKYSDQLLK--KSTKNNEQVDL 455
+ A+ FIN GS + A +R ++AKY D LL+ + + +
Sbjct: 354 ETLSYAMRKAFETFINGAK-----GSQREAPAR---LIAKYIDYLLRVGEQASGGKPLKE 405
Query: 456 TVDDIMTVFKFLADKDAFEMHYRKNLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKI 515
+I+ +F+++A KD FE +Y+ ++AKRL+ S S +E +++ L+ ++T +
Sbjct: 406 VFSEILDLFRYIASKDIFEAYYKLDIAKRLLLNKSASAQNELMLLDMLKKTCGSQFTHSL 465
Query: 516 TKMLQDVKLSKNLHDEFSTFISQDGNNTTSAATFRSKVPELEPLILADNVWPFSYQPTEF 575
M +DV +SK F S+ +N +L +L+ WP SY +
Sbjct: 466 EGMFRDVNISKEFTSSFRH--SKAAHNLHR---------DLYVNVLSQAYWP-SYPESHI 513
Query: 576 ALPPVLEHSKNKLETMYTDKHSGRILKWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAI 635
LP ++ + E Y K G+ + W + +KA K + ++++FQ +
Sbjct: 514 RLPDDMQQDLDCFEKFYLSKQVGKKISWYASLGHCIVKARFPLGNK---ELSISLFQACV 570
Query: 636 LTLFNDI---STLTFEQIQERTNLKATQIASNMYPF--VKMKLLIQSPEGVESMIKLDTK 690
L FN+ ++++ +++ T L + + +++ L+ P+ + DT
Sbjct: 571 LLQFNNCLGGEGISYQDLKKSTELSDIDLTRTLQSLSCARIRPLVMVPKSKKP--SPDTM 628
Query: 691 YTLNKPYRLSKTSVNFAAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRA 750
+ +N+ + D + +N L E E E ++++ + R L+A
Sbjct: 629 FYVNEKF--------------TDKLYRVKINQIYLKE-ERQENSDVQEQVVRDRQFELQA 673
Query: 751 CIVRIMKAKRKLPHSSLMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRTDDGECYEY 810
IVR+MK K K+ H L+ I + R VS +K A++ L+E+EYL+R +D + Y Y
Sbjct: 674 SIVRVMKQKEKMKHDDLVQYVINNVKDRGIPLVSDVKTAIEKLLEKEYLER-EDNDIYTY 732
Query: 811 L 811
+
Sbjct: 733 V 733
>CE24979 [D] KOG2167 Cullins
Length = 833
Score = 134 bits (336), Expect = 7e-31
Identities = 113/391 (28%), Positives = 183/391 (45%), Gaps = 39/391 (9%)
Query: 430 RAPEMLAKYSDQLLKKSTKN---NEQVDLTVDDIMTVFKFLADKDAFEMHYRKNLAKRLI 486
R+ E+++K+ LL S KN + +D VD+ + +F++L KD FE +Y++ LAKRL
Sbjct: 474 RSAELISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRYLRGKDVFEAYYKRGLAKRLF 533
Query: 487 HGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFSTFISQDGNNTTSA 546
S S + + E +T K+ M +D+ S+N F+ ++ +
Sbjct: 534 LERSAS-------VDAGKDECGSAFTYKLEGMFKDMDASENYGRLFNQYLE---HMNKEK 583
Query: 547 ATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHSKNKLETMYTDKHSGRILKWLWP 606
A F ++V + WP +Y E +P + + + Y +H R +KW
Sbjct: 584 ANFTARV-------ITPEYWP-TYDTYEINIPKEMRDTLTDYQDFYRVQHGNRNVKWHHG 635
Query: 607 MSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDISTLTFEQIQERTNLKATQIASNMY 666
++ I A +PG + T++Q IL LFN T T +I E T + ++ N+
Sbjct: 636 LASAVISASF-RPGCKK-ELIATMYQTVILLLFNKCETWTVAEIVEHTKILEIEVVKNVL 693
Query: 667 PFV----KMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSVNFAAAVKNDLTFTATVNG 722
+ K K+L Q EG S K T L K VN K A VN
Sbjct: 694 ALLGGRDKPKVL-QRVEGGGSEKKEGTVENLKN----EKFVVNSKFTEKRCRVRIAQVN- 747
Query: 723 SALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLPHSSLMNECIAESQQRFNAK 782
+T E K+ ++E+N R + A +VRIMKA+++L H +LM E + Q RF
Sbjct: 748 ---IKTAVEETKEVKEEVNSDRQYKIDAAVVRIMKARKQLNHQTLMTELL--QQLRFPVS 802
Query: 783 VSMIKKAVDNLIEQEYLKR-TDDGECYEYLA 812
+ IKK +++LIE+EY+ R ++ Y Y+A
Sbjct: 803 TADIKKRLESLIEREYISRDPEEASSYNYVA 833
>7294516 [D] KOG2166 Cullins
Length = 670
Score = 118 bits (296), Expect = 3e-26
Identities = 170/769 (22%), Positives = 302/769 (39%), Gaps = 145/769 (18%)
Query: 49 MEVYTAIYNYCVNKSRSTGHFQSDIIGKQMNQSSILVGGEIYENLKNYLKDYISNLKKDD 108
M +Y IY C + Q + G+ + I++ + + LKN ++ + DD
Sbjct: 41 MHLYHLIYKQCAAERNWNNPAQKN--GRSLY---IVLSDCLMKRLKNIA--WVMENQLDD 93
Query: 109 N--VTFLNFYVRRWERFTIGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKE 166
N + + Y+ W + LN + NR WV++ER G + + + L +++WKE
Sbjct: 94 NKPIRLIAKYLEHWVPYQRSCEKLNLACYHFNRNWVERERLKGDKETYPIYRLAMISWKE 153
Query: 167 VMFETHKTELVTEIFDQLDLQRRGELVNKSAITIAIKSFVILGIDPSDLKK-LNLNVYIQ 225
++FE ++TI +IL P + K L VY
Sbjct: 154 LVFEP-------------------------SVTILAAIRLILSQMPREYNKSLEYQVY-- 186
Query: 226 NFEQPFLQKTKEYYTKMSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTA 285
LQ E Y +N+ S+ I+K IF EK M Y ST
Sbjct: 187 ----QVLQSIVELY---ANDKYQDVSLPSRIDK-----IFTEKVMDFYK--------STT 226
Query: 286 LNQVLIADHADKLKKEFILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGN- 344
L++ Q+++ + DY+ + + + + N
Sbjct: 227 LHEF---------------------QKIV------VSNDYKDFKHFLRYACLAMPEIENG 259
Query: 345 EEIDKLIDAHNKSAAQDSNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAKAL 404
+ ++ + + Q++ LS +DY++ +G+ + +H A+ +
Sbjct: 260 TQFKAILKRYLAARLQETR------LSGKDYIQAFLGLCR---GPLQRALRDHTKLAEVV 310
Query: 405 DYGCRCFINNNSFAIPPGSPKFATSRAPEMLAKYSDQLLKKSTKNNEQVDLTVDDIMTVF 464
D C+ IN I P +L Y+++L+ K ++ E + + I+
Sbjct: 311 DAVCKEEINRKGQIIDP----------TRLLVTYANELMTKRQESEEAIIDELKRIVKCV 360
Query: 465 KFLADKDAFEMHYRKNLAKRLIHGSSKSEADEEIIIQRLQSENSLEYTSKITKMLQDVKL 524
+FL+D+ F Y K L R I+ +S S+ E I+ L + + T I L+DV
Sbjct: 361 EFLSDEYKFIDMYLKALRIRQINETSTSDGVESIMYSLLNKKMANFVTRCIYVQLRDVDK 420
Query: 525 SKNLHDEFSTFISQDGNNTTSAATFRSKVPELEPLILADNVWPFSYQPTEFALPPVLEHS 584
+ L EF ++ G FR K + + S++ LP L+ +
Sbjct: 421 LRTLKKEFQDHLNSKG--IKLGFDFRPKCFKNDG----------SFENFNLTLPDELQQA 468
Query: 585 KNKLETMYTDK--HSGRILKWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDI 642
+ Y + S I++ +S GEI H+ + + V+ QMA+L LFN
Sbjct: 469 WKEFRIFYEARKLQSKAIIQLNNELSSGEITCHL---NQSVYILEVSTLQMAVLMLFNRH 525
Query: 643 STLTFEQIQERTNLKATQIASNMYPFVKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKT 702
T QE ++ + ++K L+ + I+++ +T N+ RL
Sbjct: 526 ERFT---EQELVTALGVELETLQEALKQIKFLVYIEVNKVNYIEINMDFT-NRKRRL--- 578
Query: 703 SVNFAAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKL 762
L ++K+E EL +R + A IVRIMK +++L
Sbjct: 579 -----------------FCNEPLPRKMRKIEEKSEIELKIRRDKQVDAAIVRIMKGQKQL 621
Query: 763 PHSSLMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRTDDGECYEYL 811
+S L++ E + R +VS IKK +D L+E+EYL+R + Y YL
Sbjct: 622 EYSELISLVYEELKDRVKPQVSFIKKRLDYLVEREYLERDNYYNIYRYL 670
>At1g59790 [D] KOG2166 Cullins
Length = 374
Score = 86.3 bits (212), Expect = 2e-16
Identities = 88/406 (21%), Positives = 168/406 (40%), Gaps = 66/406 (16%)
Query: 6 PRSDDLEATWNFVKPGIDQILDRDGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVNKSRS 65
PR E W+ ++ GI +++ I + ++YT IY+ CV +S
Sbjct: 9 PRQIKFEEGWSNIQKGITKLIR------ILEGEPEPTFYFSECFKLYTIIYDMCVQRSDY 62
Query: 66 TGHFQSDIIGKQMNQSSILVGGEIYENLKNYLKDY-----ISNLKKDDNVTFLNFYVRRW 120
+ ++YE + ++DY + +L++ + L V+RW
Sbjct: 63 SQ--------------------QLYEKYRKVIEDYTIQTVLPSLREKHDEDMLRELVKRW 102
Query: 121 ERFTIGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTEI 180
I +L++ F Y++R+ V++ + + + C + ++ E+V +
Sbjct: 103 NNHKIMVKWLSKFFVYIDRHLVRRSKIPIPS-LDEVGLTCFLDLVYCEMQSTAKEVVIAL 161
Query: 181 FDQLDLQRRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYYT 240
+ +R GE ++++ + + +V G+ L Y ++FE LQ T YY+
Sbjct: 162 IHK---EREGEQIDRALVKNVLDIYVENGMG-------TLEKYEEDFESFMLQDTASYYS 211
Query: 241 KMSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPLSTAL-NQVLIADHADKLK 299
+ ++ + + S +Y+ K EC+ E + + YL S T L + N++L+ ++L+
Sbjct: 212 RKASRWTEEDSCPDYMIKVEECLKMERERVTHYLHSITEPKLVEKIQNELLVMVTKNRLE 271
Query: 300 KE---FILLLDKQDQRLIKLIYELMKRDYRMLPDLVDTFDMYIKRVGNEEIDKLIDAHNK 356
E F LL + + IY L + L + D F +I GN I + A +K
Sbjct: 272 NEHSGFSALLRDDKKNDLSRIYRLYLPIPKRLGRVADLFKKHITEEGNALIKQ---ADDK 328
Query: 357 SAAQDSNAKRQPGLSPRDYLKCLIGVYKLFYNITIECFENHPAFAK 402
+ Q LI ++ F IECF+NH F K
Sbjct: 329 TTNQ-----------------LLIELHNKFIVYVIECFQNHTLFHK 357
>Hs22049312 [D] KOG2166 Cullins
Length = 209
Score = 84.3 bits (207), Expect = 7e-16
Identities = 47/124 (37%), Positives = 73/124 (57%), Gaps = 12/124 (9%)
Query: 426 FATSRAPEMLAKYSDQLLKKSTKNNEQVDL--TVDDIMTVFKFLADKDAFEMHYRKNLAK 483
+ +S + E LA+Y D LKKS+KN ++ +L T++ IM VFK++ DKD F+ Y K LAK
Sbjct: 3 YLSSNSHESLAQYYDSFLKKSSKNTDEAELEDTLNHIMVVFKYIEDKDVFQKFYAKMLAK 62
Query: 484 RLIHGSSKSEAD----------EEIIIQRLQSENSLEYTSKITKMLQDVKLSKNLHDEFS 533
RLI+ +S D E + +L+ EYTSK+ M QD +SK+L+++F
Sbjct: 63 RLIYQNSDDANDDARKAVSDNAEASMFSKLKQACGFEYTSKLQWMFQDTGVSKDLNEQFK 122
Query: 534 TFIS 537
++
Sbjct: 123 NHLT 126
>YJL047c [D] KOG2166 Cullins
Length = 842
Score = 67.8 bits (164), Expect = 6e-11
Identities = 73/347 (21%), Positives = 150/347 (43%), Gaps = 37/347 (10%)
Query: 486 IHGSSKSEADEEIIIQRLQSENSLEYTSK----ITKMLQDVKLSKNLHDEFSTFISQDGN 541
++ S E ++ II + E+ + Y + +++ Q V++ +L ++++F+S
Sbjct: 511 VYKDSLMELFKQRIITNVSQEDEMRYRDQYQPYLSQFFQPVEVMADLRIKYASFLSFY-E 569
Query: 542 NTTSAATFRSKVPELE-----PLILADNVWPFSYQPTE-----FALPPVLEHSKNKLETM 591
N +A F E PLI P +Q + F LP ++ + N+
Sbjct: 570 NIEAAVKFGKTYNENNSKSFFPLIFDRERIPKVFQQSNEVKKNFVLPQEMDDTWNQFLRN 629
Query: 592 YTDKH-------SGRILKWLWPMSRGEIKAHIGKPGKPPFQFTVTIFQMAILTLFNDIST 644
Y +++ S + L +W + E+++ F +T+FQ +LTLFN+
Sbjct: 630 YHEQNKVEDSDASKKELYPMWNLHHCEVESPYIIQDGTNLIFELTLFQTCVLTLFNESDH 689
Query: 645 LTFEQIQERTNLKATQIASNMYPFVKMKLLIQSPEGVESMIKLDTKYTLNKPYRLSKTSV 704
LT + I E+T L +A + F K+L + +D Y++N+ ++ V
Sbjct: 690 LTLQVISEQTKLAYKDLALVLKSFCNYKILTRD---------IDNTYSINESFKPDMKKV 740
Query: 705 -NFAAAVKNDLTFTATVNGSALDETEASEQKKAEKELNQQRLMFLRACIVRIMKAKRKLP 763
N V T + + + + T ++ + + + Q+ L+ACI R +K++R
Sbjct: 741 KNGKLRVVLPRTASLQSSNTGGERTSSAHHEGSNSQWTQE---LLKACITRSVKSERNGL 797
Query: 764 HSSLMNECIAESQQRFNAKVSMIKKAVDNLIEQEYLKRTDDGECYEY 810
+ E + + + F+ V K A+ L+ +++ R + Y+Y
Sbjct: 798 DYDHLFETVKQQIKGFS--VGEFKDALAKLLRDKFITRDESTATYKY 842
>At1g59800 [D] KOG2166 Cullins
Length = 255
Score = 51.2 bits (121), Expect = 6e-06
Identities = 52/283 (18%), Positives = 113/283 (39%), Gaps = 48/283 (16%)
Query: 6 PRSDDLEATWNFVKPGIDQILDR-DGTSDIKTNRVQKVLSPRMYMEVYTAIYNYCVNKSR 64
P E W+ ++ G +++ +G S+ N+ + M ++TA Y C K+
Sbjct: 4 PTEIKFEVEWSNIQQGFTKLIRMIEGESEPAFNQ-------EIMMMMHTATYRICAYKNP 56
Query: 65 STGHFQSDIIGKQMNQSSILVGGEIYENLKNYLKDY-----ISNLKKDDNVTFLNFYVRR 119
++Y+ + +++Y + +L++ + L +R
Sbjct: 57 Q----------------------QLYDKYRELIENYAIQTVLPSLREKHDECMLRELAKR 94
Query: 120 WERFTIGAIFLNRVFDYMNRYWVQKERSDGKRHIFDAHTLCLMTWKEVMFETHKTELVTE 179
W + +R Y++ ++ K+ R + L +++ ++ ++
Sbjct: 95 WNAHKLLVRLFSRRLVYLDDSFLSKKGLPSLREVG------LNCFRDQVYREMQSMAAEA 148
Query: 180 IFDQLDLQRRGELVNKSAITIAIKSFVILGIDPSDLKKLNLNVYIQNFEQPFLQKTKEYY 239
I + +R GE +++ + I FV G+ LKK Y ++FE+ LQ T YY
Sbjct: 149 ILALIHKEREGEQIDRELVRNVIDVFVENGM--GTLKK-----YEEDFERLMLQDTASYY 201
Query: 240 TKMSNEFLDSHSVSEYIEKANECIIFEEKDMILYLDSHTSAPL 282
+ ++ ++ S +Y K +C+ E + + YL T L
Sbjct: 202 SSKASRWIQEESCLDYTLKPQQCLQRERERVTHYLHPTTEPKL 244
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.134 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,269,778
Number of Sequences: 60738
Number of extensions: 2031509
Number of successful extensions: 6407
Number of sequences better than 1.0e-05: 35
Number of HSP's better than 0.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 6175
Number of HSP's gapped (non-prelim): 49
length of query: 812
length of database: 30,389,216
effective HSP length: 115
effective length of query: 697
effective length of database: 23,404,346
effective search space: 16312829162
effective search space used: 16312829162
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)