ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI1748 check: MH TU KOG1818 Intracellular trafficking, secretion, and vesicular transport Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains
r_klactVI1748 check: MH TU KOG1818 Signal transduction mechanisms Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI1748 625254 623446 -603
(603 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNR006w [TU] KOG1818 Membrane trafficking and cell signaling pro... 489 e-138
SPAC19A8.05c [TU] KOG1818 Membrane trafficking and cell signalin... 241 2e-63
CE06781 [TU] KOG1818 Membrane trafficking and cell signaling pro... 117 4e-26
Hs4758528 [TU] KOG1818 Membrane trafficking and cell signaling p... 111 4e-24
7295922 [TU] KOG1818 Membrane trafficking and cell signaling pro... 87 1e-16
7301552 [R] KOG1819 FYVE finger-containing proteins 70 9e-12
Hs10835109 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosp... 64 7e-10
Hs20543659 [TU] KOG1818 Membrane trafficking and cell signaling ... 63 1e-09
Hs22062923 [R] KOG0504 FOG: Ankyrin repeat 62 2e-09
Hs7705278_2 [R] KOG0504 FOG: Ankyrin repeat 62 3e-09
Hs8922921 [R] KOG1729 FYVE finger containing protein 61 4e-09
Hs10863893 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosp... 61 4e-09
Hs22044271 [TU] KOG1786 Lysosomal trafficking regulator LYST and... 61 6e-09
YGL023c [R] KOG1729 FYVE finger containing protein 60 7e-09
Hs13376757 [R] KOG1729 FYVE finger containing protein 60 1e-08
7290174 [R] KOG1729 FYVE finger containing protein 60 1e-08
At1g61690 [TU] KOG1818 Membrane trafficking and cell signaling p... 59 2e-08
CE01110 [R] KOG1729 FYVE finger containing protein 59 3e-08
At3g14270 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase ... 59 3e-08
7294938 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 58 4e-08
Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 56 1e-07
CE20122 [TU] KOG1786 Lysosomal trafficking regulator LYST and re... 56 1e-07
At3g43230 [S] KOG1843 Uncharacterized conserved protein 55 3e-07
At4g33240 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase ... 55 4e-07
Hs18482373 [S] KOG1409 Uncharacterized conserved protein contain... 54 5e-07
Hs16418439 [S] KOG1409 Uncharacterized conserved protein contain... 54 5e-07
Hs13375827 [R] KOG1729 FYVE finger containing protein 54 5e-07
CE28920 [R] KOG0504 FOG: Ankyrin repeat 54 5e-07
Hs4885637 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 54 9e-07
At1g29800 [S] KOG1843 Uncharacterized conserved protein 53 1e-06
7297694 [S] KOG1409 Uncharacterized conserved protein contains W... 53 1e-06
Hs13236547 [R] KOG1729 FYVE finger containing protein 53 2e-06
7299446 [R] KOG1811 Predicted Zn2+-binding protein contains FYVE... 52 3e-06
SPBC9B6.03 [R] KOG1729 FYVE finger containing protein 51 4e-06
CE27055 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 51 4e-06
CE25764 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 51 4e-06
Hs14784247 [R] KOG1811 Predicted Zn2+-binding protein contains F... 51 6e-06
>YNR006w [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 622
Score = 489 bits (1258), Expect = e-138
Identities = 277/609 (45%), Positives = 373/609 (60%), Gaps = 66/609 (10%)
Query: 9 SEFDALIEQCTNEKIPNGEIDLSAALELSDMIRSRRLPPKDAMRCLKKRVLQTRNNQNLQ 68
SE DALIEQ T+E IPNG++DL ALE+SD++RSRR+ PKD+MRC+KKR+L T +N N Q
Sbjct: 7 SELDALIEQATSESIPNGDLDLPIALEISDVLRSRRVNPKDSMRCIKKRILNTADNPNTQ 66
Query: 69 FSVWRLVEVCMKNGGVPFLKEVCSREFMDCLEQVILAESTDYELEQFCSRLVGELYLAFK 128
S W+L +C+KNGG PF+KE+CSREFMD +E VIL E ++ EL + ++ ELY+AFK
Sbjct: 67 LSSWKLTNICVKNGGTPFIKEICSREFMDTMEHVILREDSNEELSELVKTILYELYVAFK 126
Query: 129 NDSQLSYVVKVYQKLVSRGIDM-ENLKPTENLNAMFDAKTPADWIDSDACMICSTQFTLL 187
NDSQL+YV KVY KL+SRGI E L + + AMFD+KTPADWIDSDACMICS +F+LL
Sbjct: 127 NDSQLNYVAKVYDKLISRGIKFPEKLTLSNSPTAMFDSKTPADWIDSDACMICSKKFSLL 186
Query: 188 NRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFEDYDLXXXXXXXXX------ 241
NRKHHCRSCGGVFCQ HSS IPLPDLGI+EPVRVCD+CFEDYDL
Sbjct: 187 NRKHHCRSCGGVFCQEHSSNSIPLPDLGIYEPVRVCDSCFEDYDLKRHDDSKKSKKHRHK 246
Query: 242 XXXXXXFTRSEDDDEDLRRAIELSLKE--NGRDADTFIP--DTAXXXXXXXXXXXXXXXX 297
++ ED++E +R+AIELSLKE N ++ +P ++
Sbjct: 247 RKKDRDYSTPEDEEELIRKAIELSLKESRNSASSEPIVPVVESKNEVKRQEIEEEEDPDL 306
Query: 298 XAAIEASLREHQQEEMRRKSQ-AKNMYNTSSPSVAPPIENNYDLSSNEEEDIHLFASLVE 356
AAI+ SLRE ++ ++R + Q A PS P ++ DLS E++ I++FASLVE
Sbjct: 307 KAAIQESLREAEEAKLRSERQKASRQMQPQQPSPQPQPIHSVDLSDEEKDSIYMFASLVE 366
Query: 357 RMKTQPPTAVLEDTQLQQLYQKVLGVRPKLNYALSDTVSKYNTVYEMNSKISDIMNMYDS 416
+MK++P +LED++LQ L Q+V + +LNYAL+D KYNT+ EMN KIS+IMN+YD
Sbjct: 367 KMKSRPLNEILEDSKLQNLAQRVFASKARLNYALNDKAQKYNTLIEMNGKISEIMNIYDR 426
Query: 417 MLEMQLRNISLSQQYAIPESGRNSYGYHQNMPQ-----YDQPNSPQIIAQPQIHSPQQN- 470
+LE QL++I+LSQQY +P+ + Y Y Q Y P Q+ + + PQQ+
Sbjct: 427 LLEQQLQSINLSQQYTLPQVPSDPYNYLTENVQNPAESYQTPPLQQLSSHQ--YKPQQDV 484
Query: 471 --ERTILNYASPVS--QHLSNGATTNTYQQGSXXXXXXXXXXXXXXVSFEKPSTTSQLEG 526
++++ +SP + HL T QQ KP + +L
Sbjct: 485 SRQQSVKANSSPTTNIDHLKTIDVTPHAQQ--------------------KPQSHVEL-- 522
Query: 527 LILEEPSEPPYP-----DENTTI---ENPKIEQASERPYPDD--------HLKQENITSF 570
PS+PPYP DE T E +++ ERPYP + + + + IT +
Sbjct: 523 ----APSDPPYPKEEAEDEGTQAVQDEESSTQESRERPYPVETENGETSINKRPQGITRY 578
Query: 571 DFPTVPLRK 579
DFPTVP RK
Sbjct: 579 DFPTVPARK 587
>SPAC19A8.05c [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 610
Score = 241 bits (616), Expect = 2e-63
Identities = 176/528 (33%), Positives = 269/528 (50%), Gaps = 63/528 (11%)
Query: 7 SVSEFDALIEQCTNEKIPNGEIDLSAALELSDMIRSRRLPPKDAMRCLKKRVLQTRNNQN 66
S S+F + IE+ T+E +P G ++S LE+SD IRS+ + PK AMR LK R+ +N N
Sbjct: 7 SNSQFASDIEKATSETLPAGSEEISLYLEISDQIRSKSVDPKFAMRILKSRI--DHSNPN 64
Query: 67 LQFSVWRLVEVCMKNGGVPFLKEVCSREFMDCLEQVILAES-TDYELEQFCSRLVGELYL 125
+Q +L + C+KNGG FL E+ SREFMD L ++ + + D +++ R + L
Sbjct: 65 VQIMALKLTDTCVKNGGSGFLLEIASREFMDNLVSILRSPAGIDEDVKMVILRYIQSWAL 124
Query: 126 AFKN-DSQLSYVVKVYQKLVSRGIDMENLKPTENLNAMF-DAKTPADWIDSDACMICSTQ 183
A + +S LSY++ VYQ L + D E +P++N+ + F D +TP DW DS+ C+ C T
Sbjct: 125 AVPDTNSPLSYIIHVYQNL--KDGDYEFPEPSQNITSKFLDTETPPDWTDSEVCLRCRTP 182
Query: 184 FTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFE-DYDLXXXXXXXXXX 242
FT NRKHHCR+CGGVFC SSK + LP LGI +PVRVCD+C+
Sbjct: 183 FTFTNRKHHCRNCGGVFCNQCSSKTLSLPHLGINQPVRVCDSCYSLRTKPKGSKSRARNE 242
Query: 243 XXXXXFTR-------SEDDDEDLRRAIELSLKE--NGRDADTF-IPDTA--XXXXXXXXX 290
TR + ++DED++RAIELSLKE R+ ++ P A
Sbjct: 243 RKFHAKTRKTPSKPVTNNEDEDIKRAIELSLKEMPQSREPPSYERPSEANVVISQDQHLT 302
Query: 291 XXXXXXXXAAIEASLREHQQEEMRRKS-QAKNMYNTSSPSV---------------APPI 334
AI SL E Q+ + + A N N S PSV P
Sbjct: 303 EDEDEELKRAIAISLEEAQKSSQKDDNVTAPNNMNISYPSVPAHTVSTDIRSSPFSGRPS 362
Query: 335 ENNYDLSSNEEED-IHLFASLVERMKTQPPTAVLEDTQLQQLYQKVLGVRPKLNYALSDT 393
+N L S + D I L+A+LV+++K PP ++ + QLQ+L++ + +R ++ +L +T
Sbjct: 363 DNPSTLISTADADNITLYATLVQKLKKLPPGSIFTEYQLQELHENMGVMRTRMMRSLGET 422
Query: 394 VSKYNTVYEMNSKISDIMNMYDSMLEMQL--------------RNISLSQQYAIPESGRN 439
+SKYN + + K+ M + D+++E +L N S+ + + + RN
Sbjct: 423 MSKYNGLIQALQKLQTCMRLNDALIEQRLSSTYAHHYIDSSMDSNRSIEPEPDVISTVRN 482
Query: 440 SYGYHQNMPQYDQPNSPQIIA-------QPQIHSPQQNER-TILNYAS 479
S +PQ + P+I+ P HS ++ TI +Y S
Sbjct: 483 S----STIPQASSSSVPKIVVDSSPVTENPPSHSDVMGQKDTISSYYS 526
>CE06781 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 765
Score = 117 bits (294), Expect = 4e-26
Identities = 69/229 (30%), Positives = 118/229 (51%), Gaps = 12/229 (5%)
Query: 2 ALPSMSVSEFDALIEQCTNEKI--PNGEIDLSAALELSDMIRSRRLPPKDAMRCLKKRVL 59
A+ ++F +++Q T+ + PN E + +DMIRS +P K +++ ++KR+
Sbjct: 32 AMNKKMATKFQRVLDQATDSTLVEPNWE----GIILCTDMIRSGEVPAKPSLQAIRKRM- 86
Query: 60 QTRNNQNLQFSVWRLVEVCMKNGGVPFLKEVCSREFMDCLEQVILAESTDYELEQFCSRL 119
N ++ +++ C+KN G EV +REFM+ + ++ D E++ +
Sbjct: 87 -QHENPHVVNHTLLVLDACVKNCGHKVHAEVATREFMEDFKNLVTENKYD-EVKNKSLEM 144
Query: 120 VGELYLAFKNDSQLSYVVKVYQKLVSRGIDMENLKPTENLNAMFDAKTPADWIDSDACMI 179
+ AF N + VV + + G D +LK + AMF A+ +W D C
Sbjct: 145 LQCWATAFANKPEYKMVVDTHNLMKLAGFDFPSLKEAD---AMFMAQVAPEWADGPECYR 201
Query: 180 CSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFE 228
C + F++ RKHHCR+CG +FC SS+ + LP GI + VRVC+ C+E
Sbjct: 202 CRSVFSVFTRKHHCRACGQIFCDKCSSRELALPQFGIEKEVRVCETCYE 250
>Hs4758528 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 777
Score = 111 bits (277), Expect = 4e-24
Identities = 68/220 (30%), Positives = 117/220 (52%), Gaps = 12/220 (5%)
Query: 11 FDALIEQCTNEKIPNGEIDLSAALELSDMIRSRRLPPKDAMRCLKKRVLQTRNNQNLQFS 70
F+ L+++ T++ + E D + L++ D+IR K A+ +KK+V N++N +
Sbjct: 8 FERLLDKATSQLLL--ETDWESILQICDLIRQGDTQAKYAVNSIKKKV----NDKNPHVA 61
Query: 71 VWRL--VEVCMKNGGVPFLKEVCSREFMDCLEQVILAESTDYELEQFCSRLVGELYLAFK 128
++ L +E +KN G EV +++ M+ L+ +L + + L+ AF+
Sbjct: 62 LYALEVMESVVKNCGQTVHDEVANKQTMEELKD-LLKRQVEVNVRNKILYLIQAWAHAFR 120
Query: 129 NDSQLSYVVKVYQKLVSRGIDMENLKPTENLNAMFDAKTPADWIDSDACMICSTQFTLLN 188
N+ + V YQ + G K ++ AMF A+ DW+D++ C C QF ++
Sbjct: 121 NEPKYKVVQDTYQIMKVEGHVFPEFKESD---AMFAAERAPDWVDAEECHRCRVQFGVMT 177
Query: 189 RKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFE 228
RKHHCR+CG +FC SSK+ +P GI + VRVC+ C+E
Sbjct: 178 RKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYE 217
>7295922 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 672
Score = 86.7 bits (213), Expect = 1e-16
Identities = 48/123 (39%), Positives = 64/123 (52%), Gaps = 4/123 (3%)
Query: 106 ESTDYE-LEQFCSRLVGELYLAFKNDSQLSYVVKVYQKLVSRGIDMENLKPTENLNAMFD 164
EST +E + Q LV AF++ + + L ++G L+ + AMF
Sbjct: 7 ESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREAD---AMFT 63
Query: 165 AKTPADWIDSDACMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCD 224
A T +W D C C +FT NRKHHCR+CG VFC ++K PLP GI + VRVCD
Sbjct: 64 ADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCD 123
Query: 225 NCF 227
CF
Sbjct: 124 GCF 126
>7301552 [R] KOG1819 FYVE finger-containing proteins
Length = 920
Score = 70.1 bits (170), Expect = 9e-12
Identities = 30/64 (46%), Positives = 40/64 (61%), Gaps = 3/64 (4%)
Query: 167 TPADWID---SDACMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVC 223
+P WI + CM C T FT R+HHCR+CGGVFC + S+ PLP G+ + VRVC
Sbjct: 833 SPPAWIPDGKAPRCMACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVC 892
Query: 224 DNCF 227
+C+
Sbjct: 893 RDCY 896
>Hs10835109 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 1198
Score = 63.9 bits (154), Expect = 7e-10
Identities = 24/51 (47%), Positives = 34/51 (66%)
Query: 177 CMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCF 227
C C + F L +RKHHCR+CG VFC ++ +P+P +FEP RVC +C+
Sbjct: 1125 CYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCY 1175
>Hs20543659 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 777
Score = 62.8 bits (151), Expect = 1e-09
Identities = 35/90 (38%), Positives = 52/90 (56%), Gaps = 5/90 (5%)
Query: 144 VSRGIDMENLKPTENLNA-MFDAKTPADWIDSD---ACMICSTQFTLLNRKHHCRSCGGV 199
+++ + +L PT+ + + + D PA W + +C C+T F + KHHCR+CG
Sbjct: 567 MAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGEG 626
Query: 200 FCQLHSSKFIPLPDLGIF-EPVRVCDNCFE 228
FC SSK P+P+ G PVRVCDNC+E
Sbjct: 627 FCDSCSSKTRPVPERGWGPAPVRVCDNCYE 656
Score = 53.5 bits (127), Expect = 9e-07
Identities = 28/71 (39%), Positives = 35/71 (48%), Gaps = 3/71 (4%)
Query: 159 LNAMFDAKTPADWIDSDA---CMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLG 215
L + DA PA W+ C C +F++ KHHCR+CG FC S +P G
Sbjct: 700 LGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRG 759
Query: 216 IFEPVRVCDNC 226
PVRVC NC
Sbjct: 760 WDHPVRVCFNC 770
>Hs22062923 [R] KOG0504 FOG: Ankyrin repeat
Length = 794
Score = 62.4 bits (150), Expect = 2e-09
Identities = 25/58 (43%), Positives = 35/58 (60%)
Query: 171 WIDSDACMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFE 228
W D C C+ +F + RKHHCR CG + C S+K IP+ + +PVRVC+ CF+
Sbjct: 729 WCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICFD 786
>Hs7705278_2 [R] KOG0504 FOG: Ankyrin repeat
Length = 860
Score = 61.6 bits (148), Expect = 3e-09
Identities = 25/58 (43%), Positives = 34/58 (58%)
Query: 171 WIDSDACMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFE 228
W D C C+ +F + RKHHCR CG + C S+K IP+ + +PVRVC CF+
Sbjct: 795 WCDGSYCYECTARFGVATRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCTICFD 852
>Hs8922921 [R] KOG1729 FYVE finger containing protein
Length = 432
Score = 61.2 bits (147), Expect = 4e-09
Identities = 34/88 (38%), Positives = 53/88 (59%), Gaps = 6/88 (6%)
Query: 145 SRGIDMENLKPTENLNAMFDAKTPADWID---SDACMICSTQFTLLNRKHHCRSCGGVFC 201
SR +D + + E ++ + +K P WI + CMIC+++FTL R+HHCR+CG + C
Sbjct: 197 SRSLDEADSENKEEVSPL-GSKAPI-WIPDTRATMCMICTSEFTLTWRRHHCRACGKIVC 254
Query: 202 QLHSSKFIPLPDLGIFEPVRVCDNCFED 229
Q SS L D +P RVC++CF++
Sbjct: 255 QACSSNKYGL-DYLKNQPARVCEHCFQE 281
>Hs10863893 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 1195
Score = 61.2 bits (147), Expect = 4e-09
Identities = 23/52 (44%), Positives = 34/52 (65%)
Query: 177 CMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFE 228
C C +F L R+HHCR+CG VFC +P+PD +++PV VC++C+E
Sbjct: 1120 CYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYE 1171
>Hs22044271 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 1513
Score = 60.8 bits (146), Expect = 6e-09
Identities = 26/53 (49%), Positives = 34/53 (64%)
Query: 175 DACMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCF 227
D+C CS +F+L R+HHCR+CG +FCQ S + L I PVRVC NC+
Sbjct: 1445 DSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCY 1497
>YGL023c [R] KOG1729 FYVE finger containing protein
Length = 635
Score = 60.5 bits (145), Expect = 7e-09
Identities = 50/164 (30%), Positives = 66/164 (39%), Gaps = 24/164 (14%)
Query: 134 SYVVKVYQKLVSRGI---DMENLKPT-ENLN-AMFDAKTPADWIDS---DACMICSTQFT 185
SY K+ L I D NL PT N N A + T WI ++C C FT
Sbjct: 407 SYKNKISSYLFPNSIPNSDRINLIPTISNRNSARVNPPTKDHWIPDSKRNSCRYCHKPFT 466
Query: 186 LLNRKHHCRSCGGVFCQLH---------SSKFIPLPDL------GIFEPVRVCDNCFEDY 230
L RKHHCR CG +FCQ H + FI + +L G ++CD+C +Y
Sbjct: 467 LWERKHHCRHCGDIFCQDHLRHWLYLDSQANFIMINELNNGGINGGGTLCKICDDCLVEY 526
Query: 231 D-LXXXXXXXXXXXXXXXFTRSEDDDEDLRRAIELSLKENGRDA 273
+ L EDDD D R+ + K +A
Sbjct: 527 ENLSTTNHNANTNEDNINVEEGEDDDNDNRKKLRNYYKNRQMNA 570
>Hs13376757 [R] KOG1729 FYVE finger containing protein
Length = 310
Score = 59.7 bits (143), Expect = 1e-08
Identities = 32/90 (35%), Positives = 46/90 (50%), Gaps = 6/90 (6%)
Query: 141 QKLVSRGIDMENLK-PTENLNAMFDAKTPADWIDSDA---CMICSTQFTLLNRKHHCRSC 196
Q L G+ + K E++ + A W+ D C C +F++ RKHHCR+C
Sbjct: 210 QALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNC 269
Query: 197 GGVFCQLHSSKFIPLPDLGIFEPVRVCDNC 226
G +FC SS + LP +PVRVCD+C
Sbjct: 270 GHIFCNTCSSNELALPSYP--KPVRVCDSC 297
>7290174 [R] KOG1729 FYVE finger containing protein
Length = 316
Score = 59.7 bits (143), Expect = 1e-08
Identities = 33/76 (43%), Positives = 43/76 (56%), Gaps = 7/76 (9%)
Query: 154 KPTENLNAMFDAKTPADWIDSDACMICS-TQFTLLNRKHHCRSCGGVFCQLHSSKFIPLP 212
KP EN A++ T D+ CM C TQFT + R+HHCR+CG V C S+K LP
Sbjct: 140 KPVENHAAVWVPDT-----DASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLP 194
Query: 213 DLGIFEPVRVCDNCFE 228
+ +RVCD C+E
Sbjct: 195 QQST-KALRVCDACYE 209
>At1g61690 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 576
Score = 58.9 bits (141), Expect = 2e-08
Identities = 25/53 (47%), Positives = 35/53 (65%), Gaps = 1/53 (1%)
Query: 172 IDSDACMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCD 224
+D+ C CS+QFT +NRKHHCR CGG+FC + + + L G PVR+C+
Sbjct: 20 VDASHCQGCSSQFTFINRKHHCRRCGGLFCGTCTQQRLSLRGQG-DSPVRICE 71
>CE01110 [R] KOG1729 FYVE finger containing protein
Length = 266
Score = 58.5 bits (140), Expect = 3e-08
Identities = 30/64 (46%), Positives = 43/64 (66%), Gaps = 5/64 (7%)
Query: 169 ADWI-DSDA--CMICS-TQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCD 224
A W+ D +A CM+C TQF L+ R+HHCR+CG V C SS+ + ++ +PVRVCD
Sbjct: 147 AVWVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRIDNVH-KKPVRVCD 205
Query: 225 NCFE 228
+CF+
Sbjct: 206 HCFD 209
>At3g14270 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related
FYVE finger-containing proteins
Length = 1791
Score = 58.5 bits (140), Expect = 3e-08
Identities = 26/70 (37%), Positives = 39/70 (55%), Gaps = 9/70 (12%)
Query: 171 WIDSDACMIC---STQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGI------FEPVR 221
W+ +C +C QFTL+NR+HHCR CG VFC ++ IP + +E +R
Sbjct: 36 WMPDQSCRVCYECDCQFTLINRRHHCRHCGRVFCGKCTANSIPFAPSDLRTPREDWERIR 95
Query: 222 VCDNCFEDYD 231
VC+ CF ++
Sbjct: 96 VCNYCFRQWE 105
>7294938 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 543
Score = 58.2 bits (139), Expect = 4e-08
Identities = 42/141 (29%), Positives = 78/141 (54%), Gaps = 8/141 (5%)
Query: 31 SAALELSDMIRSRRLPPKDAMRCLKKRVLQT--RNNQNLQFSVWRLVEVCMKNGGVPFLK 88
+A +E+ DMI +DAMR ++KR+ Q +NNQ + +++ ++E C+KN G F
Sbjct: 36 AANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTL-TVLETCVKNCGKAFHV 94
Query: 89 EVCSREFMDCLEQVILAES-TDYELEQFCSRLVGELYLAFKNDSQLSYVVKVYQKLVSRG 147
V ++F++ L ++I ++ +++ L+ AFKN L+ V ++Y +L ++G
Sbjct: 95 LVAQKDFINELVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQPDLNGVTQMYMELKNKG 154
Query: 148 IDMENLKPTENLNAMFDAKTP 168
I+ P +L+AM TP
Sbjct: 155 IEF----PANDLDAMAPIYTP 171
>Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 540
Score = 56.2 bits (134), Expect = 1e-07
Identities = 40/146 (27%), Positives = 69/146 (46%), Gaps = 6/146 (4%)
Query: 3 LPSMSVSEFDALIEQCTNEKIPNGEIDLSAALELSDMIRSRRLPPKDAMRCLKKRVLQTR 62
+P + + FD +E+ T+E N D L++ D + R PKD +R + +RV
Sbjct: 1 MPLFATNPFDQDVEKATSEM--NTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRV--NH 56
Query: 63 NNQNLQFSVWRLVEVCMKNGGVPFLKEVCSREFMDCLEQVILAESTDYELEQFCSRLVGE 122
+ ++ L+ C+ N G F EVCSR+F + V+ ++ + L+ E
Sbjct: 57 KDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVL--NKGHPKVCEKLKALMVE 114
Query: 123 LYLAFKNDSQLSYVVKVYQKLVSRGI 148
FKND QLS + + + L +G+
Sbjct: 115 WTDEFKNDPQLSLISAMIKNLKEQGV 140
>CE20122 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 931
Score = 56.2 bits (134), Expect = 1e-07
Identities = 24/52 (46%), Positives = 31/52 (59%)
Query: 177 CMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFE 228
C C +FTL +RKHHCR+CG +FC S + + I PVRVC CF+
Sbjct: 869 CDDCEHKFTLADRKHHCRNCGQIFCSTCSRFESHITRMNISRPVRVCRKCFQ 920
>At3g43230 [S] KOG1843 Uncharacterized conserved protein
Length = 485
Score = 55.1 bits (131), Expect = 3e-07
Identities = 28/69 (40%), Positives = 38/69 (54%), Gaps = 5/69 (7%)
Query: 168 PADWID---SDACMICSTQFTLLN-RKHHCRSCGGVFCQLHSSKFIPLPD-LGIFEPVRV 222
P +W+ + CM CST FT + +HHCR CGG+FC+ S +P P RV
Sbjct: 169 PPEWLPDSLASTCMQCSTPFTAITCGRHHCRFCGGIFCRNCSKGRCLMPSRFRERNPQRV 228
Query: 223 CDNCFEDYD 231
CD+C+E D
Sbjct: 229 CDSCYERLD 237
>At4g33240 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related
FYVE finger-containing proteins
Length = 1757
Score = 54.7 bits (130), Expect = 4e-07
Identities = 25/70 (35%), Positives = 38/70 (53%), Gaps = 9/70 (12%)
Query: 171 WIDSDACMIC---STQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIF------EPVR 221
W+ +C +C QFT+ NR+HHCR CG VFC ++ IP P E +R
Sbjct: 33 WMPDQSCPVCYECDAQFTVFNRRHHCRLCGRVFCAKCAANSIPSPSDETKDSHEEPERIR 92
Query: 222 VCDNCFEDYD 231
VC+ C++ ++
Sbjct: 93 VCNYCYKQWE 102
>Hs18482373 [S] KOG1409 Uncharacterized conserved protein contains WD40 repeats
and FYVE domains
Length = 410
Score = 54.3 bits (129), Expect = 5e-07
Identities = 27/69 (39%), Positives = 35/69 (50%), Gaps = 11/69 (15%)
Query: 171 WIDSDACMICSTQF-----------TLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEP 219
W++SD+C C F TL R+HHCR CG C SSK P +G
Sbjct: 281 WLESDSCQKCEQPFFWNIKQMWDTKTLGLRQHHCRKCGQAVCGKCSSKRSSYPVMGFEFQ 340
Query: 220 VRVCDNCFE 228
VRVCD+C++
Sbjct: 341 VRVCDSCYD 349
>Hs16418439 [S] KOG1409 Uncharacterized conserved protein contains WD40 repeats
and FYVE domains
Length = 400
Score = 54.3 bits (129), Expect = 5e-07
Identities = 29/74 (39%), Positives = 38/74 (51%), Gaps = 12/74 (16%)
Query: 166 KTPADWIDSDACMICSTQF-----------TLLNRKHHCRSCGGVFCQLHSSKFIPLPDL 214
+TP +W+DSD+C C F + R+HHCR CG C SSK +P +
Sbjct: 277 ETP-EWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSSIPLM 335
Query: 215 GIFEPVRVCDNCFE 228
G VRVCD+C E
Sbjct: 336 GFEFEVRVCDSCHE 349
>Hs13375827 [R] KOG1729 FYVE finger containing protein
Length = 249
Score = 54.3 bits (129), Expect = 5e-07
Identities = 32/72 (44%), Positives = 43/72 (59%), Gaps = 10/72 (13%)
Query: 166 KTPAD-----WI-DSDA--CMICS-TQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGI 216
KTP++ W+ DS+A CM C +FT +NR+HHCR CG V C S K LP
Sbjct: 139 KTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQS- 197
Query: 217 FEPVRVCDNCFE 228
+PVR+CD C++
Sbjct: 198 SKPVRICDFCYD 209
>CE28920 [R] KOG0504 FOG: Ankyrin repeat
Length = 861
Score = 54.3 bits (129), Expect = 5e-07
Identities = 25/56 (44%), Positives = 31/56 (54%), Gaps = 1/56 (1%)
Query: 171 WIDSDACMICSTQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNC 226
W D D C C +F+L +RKHHCR CG C S +P+ G + VRVCD C
Sbjct: 795 WSDGDTCD-CGARFSLTSRKHHCRHCGRHVCSKCSETTMPIAKYGEEKRVRVCDVC 849
>Hs4885637 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 492
Score = 53.5 bits (127), Expect = 9e-07
Identities = 41/153 (26%), Positives = 78/153 (50%), Gaps = 10/153 (6%)
Query: 21 EKIPNGEI---DLSAALELSDMIRSRRLPPKDAMRCLKKRVLQTRNNQNLQFSVWRLVEV 77
EK +G + D + +E+ D+I PKDA+R +KKR++ +N + ++ ++E
Sbjct: 18 EKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVMLAL-TVLET 76
Query: 78 CMKNGGVPFLKEVCSREFMD-CLEQVILAESTDYEL-EQFCSRLVGELYLAFKNDSQLSY 135
C+KN G F V S++F++ L + IL ++ + L+ AF++ L+
Sbjct: 77 CVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTG 136
Query: 136 VVKVYQKLVSRGIDMENLKPTENLNAMFDAKTP 168
VV +Y+ L +G++ P +L+ + TP
Sbjct: 137 VVTIYEDLRRKGLEF----PMTDLDMLSPIHTP 165
>At1g29800 [S] KOG1843 Uncharacterized conserved protein
Length = 510
Score = 53.1 bits (126), Expect = 1e-06
Identities = 25/65 (38%), Positives = 37/65 (56%), Gaps = 5/65 (7%)
Query: 168 PADWID---SDACMICSTQF-TLLNRKHHCRSCGGVFCQ-LHSSKFIPLPDLGIFEPVRV 222
P W+ + ACM+CS +F ++ +HHCR CGG+FC+ K + + +P RV
Sbjct: 179 PPKWLPDSAASACMLCSVRFHPIMCSRHHCRYCGGIFCRDCSKGKSLVPVKFRVSDPQRV 238
Query: 223 CDNCF 227
CD CF
Sbjct: 239 CDVCF 243
>7297694 [S] KOG1409 Uncharacterized conserved protein contains WD40 repeats
and FYVE domains
Length = 408
Score = 53.1 bits (126), Expect = 1e-06
Identities = 37/109 (33%), Positives = 52/109 (46%), Gaps = 16/109 (14%)
Query: 131 SQLSYVVKVYQKLVSRGIDMENLKPTENLNAMFDAKTPADWIDSDACMICSTQF------ 184
S LSY Q+L+S G D ++ +NAM K W+D++ C +CS F
Sbjct: 254 SALSYANHT-QQLISCGED--SVVVFWEMNAM--RKEVPGWVDTNNCQLCSRPFFWNFRS 308
Query: 185 -----TLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCDNCFE 228
L R+HHCR CG C S+ I +P +G VR CD C++
Sbjct: 309 MMDQKQLGIRQHHCRHCGKAVCDNCSTNRINIPIMGFEFDVRTCDPCYK 357
>Hs13236547 [R] KOG1729 FYVE finger containing protein
Length = 279
Score = 52.8 bits (125), Expect = 2e-06
Identities = 29/65 (44%), Positives = 38/65 (57%), Gaps = 5/65 (7%)
Query: 169 ADWID---SDACMICS-TQFTLLNRKHHCRSCGGVFCQLHSSKFIPLPDLGIFEPVRVCD 224
A WI +D CM C+ T+F+ L R+HHCR CG V C S + LP L +PVRVC
Sbjct: 147 APWIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLSP-KPVRVCS 205
Query: 225 NCFED 229
C+ +
Sbjct: 206 LCYRE 210
>7299446 [R] KOG1811 Predicted Zn2+-binding protein contains FYVE domain
Length = 2176
Score = 52.0 bits (123), Expect = 3e-06
Identities = 41/138 (29%), Positives = 60/138 (42%), Gaps = 13/138 (9%)
Query: 100 EQVILAESTDYELEQFCSRLVGELYLAFKNDSQLSYVV---KVYQKLVSRGIDMENLKPT 156
E IL Y+ + F + +L L L Y V + + S G D+ N
Sbjct: 1359 EAFILLNFNSYQQDHFVGQDCLDLLLRIYASKALDYHVANVRAASEPSSLGTDVHN--SL 1416
Query: 157 ENLNAMF----DAKTPADWI---DSDACMICS-TQFTLLNRKHHCRSCGGVFCQLHSSKF 208
++L F A W ++ CM C FT+L R+HHCR CG V C S+
Sbjct: 1417 DSLCGAFVMPKQAPNRQQWTRDEEASHCMCCRRAAFTMLMRRHHCRRCGRVVCYACSTHR 1476
Query: 209 IPLPDLGIFEPVRVCDNC 226
I +P+L VR+C++C
Sbjct: 1477 IRIPELYDELEVRICNDC 1494
>SPBC9B6.03 [R] KOG1729 FYVE finger containing protein
Length = 293
Score = 51.2 bits (121), Expect = 4e-06
Identities = 31/95 (32%), Positives = 44/95 (45%), Gaps = 17/95 (17%)
Query: 140 YQKLVSRGIDMENLKPTENLNAMFDAKTPADWIDSDACMICSTQFTLLNRKHHCRSCGGV 199
YQ GI ++ KP +++ P+ CS +F L +R+HHCR CG +
Sbjct: 138 YQSSRETGISKDHWKPDSDVSV---CSFPS----------CSVRFGLFDRRHHCRRCGDI 184
Query: 200 FCQLHSSKFIPLPDLGIF----EPVRVCDNCFEDY 230
FC LH + IPL F R C +CF +Y
Sbjct: 185 FCALHCDRNIPLTMDVKFCLAGSLYRSCVSCFYEY 219
>CE27055 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 403
Score = 51.2 bits (121), Expect = 4e-06
Identities = 40/141 (28%), Positives = 71/141 (49%), Gaps = 14/141 (9%)
Query: 34 LELSDMIRSRRLPPKDAMRCLKKRV--LQTRNNQNLQFSVWRLVEVCMKNGGVPFLKEVC 91
+E+ D I P+DA+R LKKR+ ++NN + +++ ++E +KN F VC
Sbjct: 61 MEICDFINGTEDGPRDAVRALKKRLHNAMSKNNAVVMYTL-TVLETAVKNCNHHFHVLVC 119
Query: 92 SREFMDCLEQVILAESTDYELEQFCSRLVGELYL----AFKNDSQLSYVVKVYQKLVSRG 147
+++F+ L ++I ++ Q V L AF+ D L+ VV+ Y L S+G
Sbjct: 120 NKDFVQDLIKLI---GPKFDAPQIIQERVLSLIQAWADAFRGDPTLAGVVQSYDDLKSKG 176
Query: 148 IDMENLKPTENLNAMFDAKTP 168
++ P +L+ + KTP
Sbjct: 177 VEF----PAADLDTLAPIKTP 193
>CE25764 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 437
Score = 51.2 bits (121), Expect = 4e-06
Identities = 40/141 (28%), Positives = 71/141 (49%), Gaps = 14/141 (9%)
Query: 34 LELSDMIRSRRLPPKDAMRCLKKRV--LQTRNNQNLQFSVWRLVEVCMKNGGVPFLKEVC 91
+E+ D I P+DA+R LKKR+ ++NN + +++ ++E +KN F VC
Sbjct: 61 MEICDFINGTEDGPRDAVRALKKRLHNAMSKNNAVVMYTL-TVLETAVKNCNHHFHVLVC 119
Query: 92 SREFMDCLEQVILAESTDYELEQFCSRLVGELYL----AFKNDSQLSYVVKVYQKLVSRG 147
+++F+ L ++I ++ Q V L AF+ D L+ VV+ Y L S+G
Sbjct: 120 NKDFVQDLIKLI---GPKFDAPQIIQERVLSLIQAWADAFRGDPTLAGVVQSYDDLKSKG 176
Query: 148 IDMENLKPTENLNAMFDAKTP 168
++ P +L+ + KTP
Sbjct: 177 VEF----PAADLDTLAPIKTP 193
>Hs14784247 [R] KOG1811 Predicted Zn2+-binding protein contains FYVE domain
Length = 989
Score = 50.8 bits (120), Expect = 6e-06
Identities = 29/81 (35%), Positives = 41/81 (49%), Gaps = 10/81 (12%)
Query: 155 PTENLNAMFDAKTPA---DWIDSDA---CMICSTQ-FTLLNRKHHCRSCGGVFCQLHSSK 207
PT+ TP W+ + CM+C + FT+ NR+HHCR CG + C S+K
Sbjct: 240 PTQPSQEFVPPATPPARHQWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTK 299
Query: 208 FIPLPDLGIFE-PVRVCDNCF 227
+ + G E P RVCD C+
Sbjct: 300 KMVVE--GCRENPARVCDQCY 318
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,737,704
Number of Sequences: 60738
Number of extensions: 1471579
Number of successful extensions: 5316
Number of sequences better than 1.0e-05: 37
Number of HSP's better than 0.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 5257
Number of HSP's gapped (non-prelim): 44
length of query: 603
length of database: 30,389,216
effective HSP length: 112
effective length of query: 491
effective length of database: 23,586,560
effective search space: 11581000960
effective search space used: 11581000960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)