ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI1977 good LA KOG2044 Replication, recombination and repair 5'-3' exonuclease HKE1/RAT1
r_klactVI1977 good LA KOG2044 RNA processing and modification 5'-3' exonuclease HKE1/RAT1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI1977 703955 706930 992
(992 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR048c [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 1236 0.0
SPAC26A3.12c [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 727 0.0
SPAC17A5.14 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involv... 433 e-121
Hs18860916 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 432 e-120
At1g75660 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 402 e-111
CE22118 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 401 e-111
At5g42540 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 390 e-108
At1g54490 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 375 e-103
7297186 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 363 e-100
CE26838 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved i... 308 3e-83
7293586 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved i... 286 1e-76
YGL173c [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved i... 285 3e-76
ECU09g0760 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 229 2e-59
Hs22041601 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involve... 56 2e-07
>YOR048c [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 1006
Score = 1236 bits (3199), Expect = 0.0
Identities = 609/944 (64%), Positives = 731/944 (76%), Gaps = 26/944 (2%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIEDGVQLPLDYSSANPNGELDNLYLDMNGIVHP 60
MGVPSFFRWLSRKYPKIISPVLEE P I DGV LPLDYS++NPNGELDNLYLDMNGIVHP
Sbjct: 1 MGVPSFFRWLSRKYPKIISPVLEEQPQIVDGVILPLDYSASNPNGELDNLYLDMNGIVHP 60
Query: 61 CSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRFRS 120
CSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVL++AVDGVAPRAKMNQQRARRFRS
Sbjct: 61 CSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLVMAVDGVAPRAKMNQQRARRFRS 120
Query: 121 ARDAKLQNEAREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKLATALRYWTSF 180
ARDA+++NEARE+++R+RE+ GE ID+ V++KKTWDSNAITPGTPFMDKLA ALRYWT+F
Sbjct: 121 ARDAQIENEAREEIMRQREEVGEIIDDAVRNKKTWDSNAITPGTPFMDKLAAALRYWTAF 180
Query: 181 KLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDADLIFLG 240
KLATDPGWKNLQ+IISDATVPGEGEHKIMNFIRSQRAD +YNPNTTHCIYGLDADLIFLG
Sbjct: 181 KLATDPGWKNLQVIISDATVPGEGEHKIMNFIRSQRADPEYNPNTTHCIYGLDADLIFLG 240
Query: 241 LATHEPHFKILREDVFANNNYKKPKPQDMINLSEEEKQQLIQQDSEKPFLWLHISVLREY 300
LATHEPHFKILREDVFA +N K+ +D IN++EEEKQ L +Q+SE+PFLWLHI+VLREY
Sbjct: 241 LATHEPHFKILREDVFAQDNRKRNNLKDTINMTEEEKQFLQKQNSEQPFLWLHINVLREY 300
Query: 301 LSAELAIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILVDIWKTVLP 360
LSAEL +P L F FD ERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDIL+DIWK VLP
Sbjct: 301 LSAELWVPGLPFTFDLERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILLDIWKVVLP 360
Query: 361 KTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQEVRKQEAHDRRKKLKSNPNVSQ 420
K KTY+TCDG LNL VE LL+ LG RE D+FK ++IQE RK+EA +RRK K N+S+
Sbjct: 361 KLKTYMTCDGVLNLPSVETLLQHLGSREGDIFKTRHIQEARKKEAFERRKAQK---NMSK 417
Query: 421 GKVDRNFMIPLENMPVYDVDGNAAEGSLNLSNKDFANMRKEINLANEGDGEXXXXXXXXS 480
G+ DR+ + E + +YD GN A+GS NL+ D ++KE+ LANEG+ E S
Sbjct: 418 GQ-DRHPTVATEQLQMYDTQGNLAKGSWNLTTSDMVRLKKELMLANEGNEEAIAKVKQQS 476
Query: 481 EKNSGVV-EFSSEELKNSVQLSKTANYDAATSLQEKLIAKKMAMRDEENAEELSLKRKSE 539
+KN+ ++ + S EE+ ++V + N++ A +++K+I KK + + EE++ K
Sbjct: 477 DKNNELMKDISKEEIDDAVSKANKTNFNLAEVMKQKIINKKHRLEKDNEEEEIAKDSKKV 536
Query: 540 DVDSAEKETSNXXXXX------------XXXXXXXXGSTVPPAVIHTGIVKSGFIDTDES 587
+ AE E S V V + K+G DTDE
Sbjct: 537 KTEKAESECDLDAEIKDEIVADVNDRENSETTEVSRDSPVHSTVNVSEGPKNGVFDTDEF 596
Query: 588 VRLYEPGYHDRYYQHKFHVPAKDIPALQKDVIRCYVEGISWVLLYYYQGCASWTWYYPYH 647
V+L+EPGYH+RYY KFHV +DI L+KD+++CY+EG++WVL+YYYQGCASW W+YPYH
Sbjct: 597 VKLFEPGYHERYYTAKFHVTPQDIEQLRKDMVKCYIEGVAWVLMYYYQGCASWNWFYPYH 656
Query: 648 YAPFAQDFKNIKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRPLMSDPNSEIIDF 707
YAP A DF +L+I F+ G PFLPYEQLMSVLPAASGHALP+IFR LMS+P+SEIIDF
Sbjct: 657 YAPLATDFHGFSHLEIKFEEGTPFLPYEQLMSVLPAASGHALPKIFRSLMSEPDSEIIDF 716
Query: 708 YPEEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARNVRKKDALLISN 767
YPEEFP+DMNGKKM+WQGIALLPFID+ RLL VR QY LSD+E+ARN+R + LLISN
Sbjct: 717 YPEEFPIDMNGKKMSWQGIALLPFIDQDRLLTAVRAQYPLLSDAERARNIRGEPVLLISN 776
Query: 768 KNVNYDLFMKNLYGENPVN---VIEFRHFKSGLSGFVTQAEEGFELNSKLICPINGGGLP 824
KN NY+ F K LY + N V++F+HFKSGLSG V++ EGFELN K++CPI GG LP
Sbjct: 777 KNANYERFSKKLYSKENNNNNVVVKFQHFKSGLSGIVSKDVEGFELNGKIVCPIQGGSLP 836
Query: 825 DLSTNLFLKLSYTQPVVAGRCKSLVLNGYIPPQPMLTPQDRDCIIYKYSN-----RWN-P 878
+LST L LK+SY + R KS++LNG+IP +P+LT D D I+YKY+N RWN
Sbjct: 837 NLSTTLILKMSYRLIPLPSRNKSIILNGFIPSEPVLTAYDLDSIMYKYNNQNYSRRWNFG 896
Query: 879 SMMKYNIVPVGPSGITQYQPRVGGYRSFFFHKEQTAYAQQPQQN 922
+ +K NIVPVGP GITQY+PR GGYR+FF+ E + QP N
Sbjct: 897 NDLKQNIVPVGPKGITQYKPRTGGYRAFFYFAELSRNNVQPAHN 940
>SPAC26A3.12c [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 991
Score = 727 bits (1876), Expect = 0.0
Identities = 395/885 (44%), Positives = 541/885 (60%), Gaps = 40/885 (4%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEE-YPVIEDGVQLPLDYSSANPNG-ELDNLYLDMNGIV 58
MGVP+ FR LSRK+ K+I+PV+E + DG ++ D S NPNG E DNLYLDMNGIV
Sbjct: 1 MGVPALFRLLSRKFAKVITPVIEAPTEKLPDGTEIEPDLSLPNPNGVECDNLYLDMNGIV 60
Query: 59 HPCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRF 118
HPCSHPE++P PETEDEM++AVFEYT+R+L M RPR++L IA+DGVAPRAKMNQQR+RRF
Sbjct: 61 HPCSHPEDRPAPETEDEMMVAVFEYTDRILAMVRPRQLLFIAIDGVAPRAKMNQQRSRRF 120
Query: 119 RSARDAKLQNEAREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKLATALRYWT 178
RS+R+A L+ E + + E + G IDEN KK+WDSN ITPGTPFMD LA +LRY+
Sbjct: 121 RSSREAALKEEELQAFIEEAKQQGIPIDENATKKKSWDSNCITPGTPFMDTLAKSLRYYI 180
Query: 179 SFKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDADLIF 238
KL +DP W+N++ I+SDA+VPGEGEHKIM FIRSQR +Y+PNT H +YGLDADLI
Sbjct: 181 INKLNSDPCWRNVRFILSDASVPGEGEHKIMEFIRSQRVKPEYDPNTHHVVYGLDADLIM 240
Query: 239 LGLATHEPHFKILREDVFANNNYKKPKPQDMINLSE-EEKQQLIQQDSEKPFLWLHISVL 297
LGLATHEPHF++LREDVF K ++ + + ++ + + +KPF+WL++S+L
Sbjct: 241 LGLATHEPHFRVLREDVFFQQGSTKKTKEERLGIKRLDDVSETNKVPVKKPFIWLNVSIL 300
Query: 298 REYLSAELAIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILVDIWKT 357
REYL EL +P+L F FD ERAIDDWVF FF GNDFLPHLP LD+R+ +++ L +IW+
Sbjct: 301 REYLEVELYVPNLPFPFDLERAIDDWVFFIFFVGNDFLPHLPSLDIRDGAVERLTEIWRA 360
Query: 358 VLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQEVRKQEAHDRRKKLKSNPN 417
LP YLT DG++NL E +L +G++E D+FK+ QE R+ E + RR++ +SN
Sbjct: 361 SLPHMGGYLTLDGSVNLARAEVILSAVGNQEDDIFKRLKQQEDRRNENYRRRQQRESNQE 420
Query: 418 VSQGKVDRNFMIPLENMPVYDVDGNAAEGSLNLSNKDFANMRKEINLANEGDGEXXXXXX 477
S+ VD N +I + S ++ D +K + +
Sbjct: 421 -SESYVD-NVVIQRS----VETQSTEVVTSSKSTSVDTKPPKKTQKIDAPAPVDLVNLSE 474
Query: 478 XXSEKNSGVV--EFSSEELKNSVQLSKTA------NYDAATSLQEKLIAKKMAMRDEENA 529
S ++ G E + N + LS+ A N AA++L+ +L++ + +++
Sbjct: 475 KTSNRSLGATNRELINNRAANRLGLSREAAAVSSVNKLAASALKAQLVSNE-TLQNVPLE 533
Query: 530 EELSLKRKSEDVDSAEKETSNXXXXXXXXXXXXXGSTVPPAVIHTGIVKSGFIDTDESVR 589
+ ++ ED DS E T P + + ++VR
Sbjct: 534 DSIASSSAYEDTDSIESSTPVVHPIDTKVSNVGQKRKAPDSTEEN--------ENTDTVR 585
Query: 590 LYEPGYHDRYYQHKFHVPAKDIPALQKDVIRCYVEGISWVLLYYYQGCASWTWYYPYHYA 649
LYEPGY +RYY+ KFH+ + D P ++ ++ YV G+ WVLLYYYQGC SWTWYYPYHYA
Sbjct: 586 LYEPGYRERYYEQKFHI-SPDEPEKIREAVKHYVHGLCWVLLYYYQGCPSWTWYYPYHYA 644
Query: 650 PFAQDFKNIKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRPLMSDPNSEIIDFYP 709
PFA DFK++ ++D+ F+L +PF PYEQL+ VLPAAS + LPE + LM+D NSEIIDFYP
Sbjct: 645 PFAADFKDLASIDVKFELNQPFKPYEQLLGVLPAASKNNLPEKLQTLMTDENSEIIDFYP 704
Query: 710 EEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARNVRKKDALLISNKN 769
E F +D+NGKK WQG+ALLPFIDE RLL V + Y +L++ E RN L IS +
Sbjct: 705 ENFTIDLNGKKFEWQGVALLPFIDENRLLNAVSKIYPQLTEEESKRNEDGSTLLFISEHH 764
Query: 770 VNYDLFMKNLYGE----NPVNVIEFRHFKSGLSGFVTQAEEGFELNSKLICPINGGGLP- 824
+ +K LY + P+ + GL G V + N + CPI+
Sbjct: 765 PMFSELVKQLYSKKRQGKPLKL--SGKMAHGLFGKV-NTNDSVIPNVSVQCPIDVTSADA 821
Query: 825 -----DLSTNLFLKLSYTQPVVAGRCKSLVLNGYIPPQPMLTPQD 864
+ N + L + P KS++L G P +LTP+D
Sbjct: 822 LQKYGSIDDNQSISLVFEVPKSHFVHKSMLLRGVKMPNRVLTPED 866
>SPAC17A5.14 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA
strand exchange and mRNA turnover
Length = 1328
Score = 433 bits (1114), Expect = e-121
Identities = 270/762 (35%), Positives = 391/762 (50%), Gaps = 112/762 (14%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIEDGVQLPLDYSSANPNGELDNLYLDMNGIVHP 60
MG+P FFRW+S +YP + S ++E + E DNLYLDMNGI+H
Sbjct: 1 MGIPKFFRWMSERYP-LCSQLIENDRI-----------------PEFDNLYLDMNGILHN 42
Query: 61 CSHP--ENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRF 118
C+H ++ PP E+EM +A+F Y + +P+K+L +AVDG APRAKMNQQR+RRF
Sbjct: 43 CTHKNDDHSSPPLPEEEMYIAIFNYIEHLFEKIKPKKLLYMAVDGCAPRAKMNQQRSRRF 102
Query: 119 RSARDAKLQNEAREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKLATALRYWT 178
R+A+DA ++AR + R ED+ E + +DSN ITPGT FM++++ L Y+
Sbjct: 103 RTAKDA---HDARLKAERNGEDFPE---------EQFDSNCITPGTTFMERVSRQLYYFI 150
Query: 179 SFKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDADLIF 238
K+ D W+N+++I S PGEGEHKIM +IR+Q+A YNPNT HC+YGLDADLI
Sbjct: 151 HKKVTNDSQWQNIEVIFSGHDCPGEGEHKIMEYIRTQKAQPSYNPNTRHCLYGLDADLIM 210
Query: 239 LGLATHEPHFKILREDVFANNNYKKPKPQDMINLSEEEKQQLIQQDSEKPFLWLHISVLR 298
LGL +H+PHF +LRE+V S ++L Q F LH+S+LR
Sbjct: 211 LGLLSHDPHFCLLREEVTFGP------------ASRNRSKELAHQK----FYLLHLSLLR 254
Query: 299 EYLSAEL--AIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILVDIWK 356
EYL E +F++D E+ +DD++ + FF GNDFLPHLP L + E ++ ++ I+K
Sbjct: 255 EYLEFEFQECRSTFTFKYDLEKILDDFILLAFFVGNDFLPHLPGLHINEGALALMFSIYK 314
Query: 357 TVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQEVRKQEAHDRRKKLKSNP 416
V+P Y+ G +N+ +E +L +L + E +E+ K E + K+N
Sbjct: 315 KVMPSAGGYINEKGVINMARLELILLELENFE---------KEIFKAEVSET----KNNG 361
Query: 417 NVSQGKVDRNFMIPLENMPVYDVDGNAAEGSLNLSNKDFANMRKEINLANEGDGEXXXXX 476
N + D I + + G L + K F + R+
Sbjct: 362 NSDKPSFDFLKYITESTNDIKAMTGEQKNYFLQI--KKFLSSREPF-------------- 405
Query: 477 XXXSEKNSGVVEFSSEELKNSVQLS--KTANYDAATSLQEKLIAKKMAMRDEENAEELSL 534
S S V + L N + LS K D L+ + DE+ E+ +
Sbjct: 406 IDFSANISSVDQRFLRRLCNDLHLSFSKIIKVDGTHLLRITFRDLEFNDEDEDEIEQDEI 465
Query: 535 KRKSEDVDSAEKETSNXXXXXXXXXXXXXGSTVPPAVIHTGIVKSGFIDTDESVRLYEPG 594
+R + D+ P + +K ++ D
Sbjct: 466 ERVLQKYDNI------------------------PLLNEEQALKEKNVEKDFIQ------ 495
Query: 595 YHDRYYQHKFHVPAKDIPALQKDVIRCYVEGISWVLLYYYQGCASWTWYYPYHYAPFAQD 654
+ D YY+ K D AL K + YVEG+ WVL YYY+GC SW WYY YH+AP D
Sbjct: 496 WKDDYYRSKVGFSYYDEEAL-KAMAERYVEGLQWVLFYYYRGCQSWGWYYNYHFAPKISD 554
Query: 655 FKNIKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRPLMSDPNSEIIDFYPEEFPV 714
++ I F +G PF P+EQLM+VLPA S +P FR LM + S IIDFYPE F +
Sbjct: 555 VLKGLDVKIDFKMGTPFRPFEQLMAVLPARSQALVPPCFRDLMVNSESPIIDFYPENFAL 614
Query: 715 DMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARN 756
D NGK +W+ + ++PFIDETRL+ + + L++ E+ RN
Sbjct: 615 DQNGKTASWEAVVIIPFIDETRLIDALASKDKFLTEEERKRN 656
>Hs18860916 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 950
Score = 432 bits (1110), Expect = e-120
Identities = 232/493 (47%), Positives = 319/493 (64%), Gaps = 32/493 (6%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIEDGVQLPLDYSSANPNG-ELDNLYLDMNGIVH 59
MGVP+FFRWLSRKYP II +EE P +GV++P+D S NPN E DNLYLDMNGI+H
Sbjct: 1 MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIH 60
Query: 60 PCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRFR 119
PC+HPE+KP P+ EDEM++A+FEY +R+ ++ RPR++L +A+DGVAPRAKMNQQR+RRFR
Sbjct: 61 PCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFR 120
Query: 120 SARDAKLQNEAREQVLREREDY----GETIDENVKSKKTWDSNAITPGTPFMDKLATALR 175
++++ EA + R RE+ G E +K + +DSN ITPGT FMD LA LR
Sbjct: 121 ASKEGM---EAAVEKQRVREEILAKGGFLPPEEIKER--FDSNCITPGTEFMDNLAKCLR 175
Query: 176 YWTSFKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDAD 235
Y+ + +L DPGWKNL +I+SDA+ PGEGEHKIM++IR QRA ++PNT HC+ G DAD
Sbjct: 176 YYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADAD 235
Query: 236 LIFLGLATHEPHFKILREDVFANNNYKKPKP-----------QDMINLSEEEKQQLIQQD 284
LI LGLATHEP+F I+RE+ N KPKP +D L E+K + +
Sbjct: 236 LIMLGLATHEPNFTIIREEFKPN----KPKPCGLCNQFGHEVKDCEGLPREKKGKHDELA 291
Query: 285 SEKP-----FLWLHISVLREYLSAELAIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLP 339
P F++L ++VLREYL EL + L F FD ER+IDDWVFMCFF GNDFLPHLP
Sbjct: 292 DSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLP 351
Query: 340 CLDVRENSIDILVDIWKTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQE 399
L++REN+ID LV+I+K V+ KT YLT G +NL+ V+ ++ +G+ E +FKK+ E
Sbjct: 352 SLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDE 411
Query: 400 --VRKQEAHDRRKKLKSNPNVSQGKVDRNFMIPLENMPVYDVDGNAAEGSLNLSNKDFAN 457
R+++ R++ + P + + + N P V N + + + ++ ++
Sbjct: 412 DSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSS 471
Query: 458 MRKEINLANEGDG 470
N + DG
Sbjct: 472 PSISPNTSFTSDG 484
Score = 230 bits (587), Expect = 7e-60
Identities = 131/305 (42%), Positives = 183/305 (59%), Gaps = 16/305 (5%)
Query: 583 DTDESVRLYEPGYHDRYYQHKFHVPAKDIPALQKDVIRCYVEGISWVLLYYYQGCASWTW 642
+ +++VRL+E G+ RYY++KF V A D ++ V++ YVEG+ WVL YYYQGCASW W
Sbjct: 504 EPEDNVRLWEAGWKQRYYKNKFDVDAAD-EKFRRKVVQSYVEGLCWVLRYYYQGCASWKW 562
Query: 643 YYPYHYAPFAQDFKNIKNLDIHFDLG-EPFLPYEQLMSVLPAASGHALPEIFRPLMSDPN 701
YYP+HYAPFA DF+ I ++ F+ G +PF P EQLM V PAASG+ LP +R LMSDP+
Sbjct: 563 YYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPD 622
Query: 702 SEIIDFYPEEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARNVRKKD 761
S IIDFYPE+F +D+NGKK AWQG+ALLPF+DE RL + E Y L+ E RN D
Sbjct: 623 SSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGD 682
Query: 762 ALLISNKNVNYDLFMKNLYGENPVNVIEF-RHFKSGLSGFVTQAEEGFELNSKLIC-PIN 819
L + + +D F+ LY +E G+ G + EE L +++C P+
Sbjct: 683 VLFVGKHHPLHD-FILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAI-LPDQIVCSPV- 739
Query: 820 GGGLPDLSTNLFLKLSYTQPVVAGR--CKSLVLNGYIPPQPMLTPQDRDCIIYKYSN--R 875
L DL+ N + +++ P A K+++L G P +L P D + K SN +
Sbjct: 740 -PMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWE----KSSNGRQ 794
Query: 876 WNPSM 880
W P +
Sbjct: 795 WKPQL 799
>At1g75660 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 985
Score = 402 bits (1034), Expect = e-111
Identities = 209/432 (48%), Positives = 286/432 (65%), Gaps = 23/432 (5%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIEDGVQLPLDYSSANPNG-ELDNLYLDMNGIVH 59
MGVPSF+RWL+ KYP +++ V+EE PV +G+++P+D S NPN E DNLYLDMNGI+H
Sbjct: 1 MGVPSFYRWLAEKYPLLVADVIEEEPVEIEGIKIPVDTSKPNPNNLEYDNLYLDMNGIIH 60
Query: 60 PCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRFR 119
PC HPE++P P T +E+ +F+Y +R+ M RPRK+L +A+DGVAPRAKMNQQR+RRFR
Sbjct: 61 PCFHPEDRPSPTTFEEVFQCMFDYIDRLFVMVRPRKLLYMAIDGVAPRAKMNQQRSRRFR 120
Query: 120 SARDAKLQNEAREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKLATALRYWTS 179
SA+DA E++ E E G + V S+ +DSN ITPGT FM L+ AL+Y+
Sbjct: 121 SAKDASDAAAEEERLREEFEREGRRLPPKVDSQ-VFDSNVITPGTEFMGVLSIALQYYVH 179
Query: 180 FKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDADLIFL 239
+L D GWKN+++I+SDA VPGEGEHKIM++IR QR ++PNT HC+YGLDADLI L
Sbjct: 180 LRLNHDVGWKNIKVILSDANVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLIML 239
Query: 240 GLATHEPHFKILREDV-----------------FANNNYKKPKPQDMINLSEEEKQQLIQ 282
GLATHE HF ILRE V FA+N KPK + E +++
Sbjct: 240 GLATHEVHFSILREVVYTPGQQERCFLCGQMGHFASNCEGKPKKR----AGESDEKGDGN 295
Query: 283 QDSEKPFLWLHISVLREYLSAELAIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLD 342
+KP+ +LHI VLREYL E+ IP+ F+ D ER +DD++F+CFF GNDFLPH+P L+
Sbjct: 296 DFVKKPYQFLHIWVLREYLELEMRIPNPPFEIDLERIVDDFIFICFFVGNDFLPHMPTLE 355
Query: 343 VRENSIDILVDIWKTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQEVRK 402
+RE +I++L+ ++K YLT NL+ VE ++ +G E +F+K+ +Q R+
Sbjct: 356 IREGAINLLMAVYKKEFRSFDGYLTDGCKPNLKRVEQFIQAVGSFEDKIFQKRAMQHQRQ 415
Query: 403 QEAHDRRKKLKS 414
E R K K+
Sbjct: 416 AERVKRDKAGKA 427
Score = 219 bits (559), Expect = 1e-56
Identities = 101/186 (54%), Positives = 133/186 (71%), Gaps = 1/186 (0%)
Query: 585 DESVRLYEPGYHDRYYQHKFHVPA-KDIPALQKDVIRCYVEGISWVLLYYYQGCASWTWY 643
++ V+L +PG+ +RYY+ KF V +++ ++KDV+ Y EG+ WV+ YY +G SW W+
Sbjct: 528 EDKVKLGQPGWRERYYEEKFSVVTPEEMERVRKDVVLKYTEGLCWVMHYYMEGVCSWQWF 587
Query: 644 YPYHYAPFAQDFKNIKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRPLMSDPNSE 703
YPYHYAPFA D K++ +DI F+LG PF P+ QL+ V PAAS HALPE +R LM+DPNS
Sbjct: 588 YPYHYAPFASDLKDLGEMDIKFELGTPFKPFNQLLGVFPAASSHALPERYRTLMTDPNSP 647
Query: 704 IIDFYPEEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARNVRKKDAL 763
IIDFYP +F VDMNGK+ +WQGIA LPFIDE RLL+ V E L+D EK RN R D L
Sbjct: 648 IIDFYPTDFEVDMNGKRFSWQGIAKLPFIDERRLLEAVSEVEFTLTDEEKRRNSRMCDML 707
Query: 764 LISNKN 769
I+ +
Sbjct: 708 FIATSH 713
>CE22118 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 892
Score = 401 bits (1031), Expect = e-111
Identities = 197/418 (47%), Positives = 281/418 (67%), Gaps = 19/418 (4%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIEDGVQLPLDYSSANPN-GELDNLYLDMNGIVH 59
MGVP+FFRWL++KYP + E+ +DG ++P+D + NPN E DNLYLDMNGI+H
Sbjct: 1 MGVPAFFRWLTKKYPATVVNANEDRQRDQDGNRVPVDCTQPNPNFQEFDNLYLDMNGIIH 60
Query: 60 PCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRFR 119
PC+HPE++P P+ EDEM +FEY +R+ ++ RPR++L +A+DGVAPRAKMNQQR+RRFR
Sbjct: 61 PCTHPEDRPAPKNEDEMFALIFEYIDRIYSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFR 120
Query: 120 SARDAKLQNEAREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKLATALRYWTS 179
++++ + + E+ G + K + +DSN ITPGTPFM +LA ALRY+
Sbjct: 121 ASKEMAEKEASIEEQRNRLMAEGIAVPPKKKEEAHFDSNCITPGTPFMARLADALRYYIH 180
Query: 180 FKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDADLIFL 239
++ D W N++II+SDA VPGEGEHKIM+++R QR + ++PNT HC+ G DADLI L
Sbjct: 181 DRVTNDASWANIEIILSDANVPGEGEHKIMDYVRKQRGNPAHDPNTVHCLCGADADLIML 240
Query: 240 GLATHEPHFKILREDVFANNNYKKPKPQDMINLSEEEKQQ--------------LIQQDS 285
G+ATHE +F I+RE+ N +P+ D+ E ++ +
Sbjct: 241 GIATHEANFNIIREEFVPN----QPRACDLCGQYGHELKECRGAENETDLGDDYCKPEQR 296
Query: 286 EKPFLWLHISVLREYLSAELAIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLDVRE 345
EK F++L I VLREYL EL++P+L F+FD ERA+DDWVF+CFF GNDFLPHLP L++RE
Sbjct: 297 EKNFIFLRIPVLREYLEKELSMPNLPFKFDVERALDDWVFLCFFVGNDFLPHLPSLEIRE 356
Query: 346 NSIDILVDIWKTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQEVRKQ 403
+ID L+ ++K ++ + K YLT DG L+ VE +++ LG E ++FK++ E R Q
Sbjct: 357 GAIDRLIKLYKEMVYQMKGYLTKDGIPELDRVEMIMKGLGRVEDEIFKRRQQDEERFQ 414
Score = 211 bits (538), Expect = 3e-54
Identities = 117/282 (41%), Positives = 158/282 (55%), Gaps = 4/282 (1%)
Query: 586 ESVRLYEPGYHDRYYQHKFHVPAKDIPALQKDVIRCYVEGISWVLLYYYQGCASWTWYYP 645
+ +RLYE G+ DRYY+ KF V + DI + V YVEG+ WVL YYYQGCASW WY+P
Sbjct: 450 DDIRLYESGWKDRYYRAKFDVGSDDIEFRHR-VAWAYVEGLCWVLRYYYQGCASWDWYFP 508
Query: 646 YHYAPFAQDFKNIKNLDIHFDLG-EPFLPYEQLMSVLPAASGHALPEIFRPLMSDPNSEI 704
YHYAPFA DF+ + F +PF P EQLMSV PAAS LP ++ LM +S I
Sbjct: 509 YHYAPFASDFETVGEFQPDFTRPTKPFNPLEQLMSVFPAASKQHLPVEWQKLMIQDDSPI 568
Query: 705 IDFYPEEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARNVRKKDALL 764
ID YP +F +D+NGKK AWQG+ALLPF+DETRLL T++ Y L+ EK RN R + +
Sbjct: 569 IDLYPADFRIDLNGKKYAWQGVALLPFVDETRLLATLQSVYPTLTAEEKQRNTRGPNRIF 628
Query: 765 ISNKNVNYDLFMKNLYGENPVNVIEFRHFKSGLSGFVTQAEEGFELNSKLICPINGGGLP 824
I + +++ F + ++ V +G+SG + + P+N
Sbjct: 629 IGRNHKSFEFFQQVAESKSDDLVPLDPTLLNGVSGKIAYDSTATAPGLPFVSPVNHDECQ 688
Query: 825 DLSTNLFLKLSYTQPVVAGR--CKSLVLNGYIPPQPMLTPQD 864
DL TN + + Y P +L L+G P+ L P D
Sbjct: 689 DLPTNCGICVLYEDPEYPQDYIFPALRLDGAKEPEKTLKPDD 730
>At5g42540 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 1012
Score = 390 bits (1001), Expect = e-108
Identities = 236/563 (41%), Positives = 322/563 (56%), Gaps = 44/563 (7%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYP--VIEDGVQLPLDYSSANPNG-ELDNLYLDMNGI 57
MGVPSF+RWL ++YP I V+EE P V GV +P+D S NPNG E DNLYLDMNGI
Sbjct: 1 MGVPSFYRWLIQRYPLTIQEVIEEEPLEVNGGGVTIPIDSSKPNPNGYEYDNLYLDMNGI 60
Query: 58 VHPCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARR 117
+HPC HPE+KP P T E+ +F+Y +R+ M RPRK+L +A+DGVAPRAKMNQQRARR
Sbjct: 61 IHPCFHPEDKPSPTTFTEVFQCMFDYIDRLFVMVRPRKLLFMAIDGVAPRAKMNQQRARR 120
Query: 118 FRSARDAKLQNEAREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKLATALRYW 177
FR+A+DA EQ+ E E G+ + V S+ +DSN ITPGT FM L+ ALRY+
Sbjct: 121 FRAAKDAAEAAAEEEQLREEFEREGKKLPPKVDSQ-VFDSNVITPGTEFMATLSFALRYY 179
Query: 178 TSFKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDADLI 237
+L +DPGWKN+++I+SDA VPGEGEHKIM++IR + YNPNT HC+YGLDADLI
Sbjct: 180 IHVRLNSDPGWKNIKVILSDANVPGEGEHKIMSYIRCNKNHPGYNPNTHHCLYGLDADLI 239
Query: 238 FLGLATHEPHFKILREDVF-----------ANNNYKKPKPQDMINLSEEEKQQLIQQD-- 284
L LATHE HF ILRE VF ++ + I E + D
Sbjct: 240 MLSLATHEIHFSILREVVFFPGEEGKCFLCGQEGHRAADCEGKIKRKTGEMLDNTEADVV 299
Query: 285 SEKPFLWLHISVLREYLSAELAIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLDVR 344
+KP+ +++I +LREYL ++ IP D R IDD++F+CFF GNDFLPH+P L++R
Sbjct: 300 VKKPYEFVNIWILREYLEHDMQIPGAKKNLD--RLIDDFIFICFFVGNDFLPHMPTLEIR 357
Query: 345 ENSIDILVDIWKTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQEVRKQE 404
E +I++L+ ++K K YLT LNL VE ++ +G E +F+K+ + R+ E
Sbjct: 358 EGAIELLMSVYKNKFRSAKKYLTDSSKLNLRNVERFIKAVGMYENQIFQKRAQVQQRQSE 417
Query: 405 AHDR---RKKLKSNPNVSQGKVDRNFMIPLENMPVYDVDGNAAEGS-----LNLS---NK 453
R R K + N + R F L + D ++ S L LS N
Sbjct: 418 RFRRDKARDKARDNAR-DNAQASRQFSGKLVQLDSLDEVSDSLHSSPSRKYLRLSLDDNI 476
Query: 454 DFANMRKEINL-ANEGDGEXXXXXXXXS---EKNSGVVEFSSEELKNSVQLSKTANYDAA 509
AN+ E +L A E D E +K G + E+ + V+L+K
Sbjct: 477 GVANVETENSLKAEELDNEEDLKFKLKKLLRDKGDGFRSGNGEQ--DKVKLNK------- 527
Query: 510 TSLQEKLIAKKMAMRDEENAEEL 532
+E+ +K A + E E++
Sbjct: 528 VGWRERYYEEKFAAKSVEEMEQI 550
Score = 202 bits (513), Expect = 3e-51
Identities = 103/263 (39%), Positives = 155/263 (58%), Gaps = 12/263 (4%)
Query: 586 ESVRLYEPGYHDRYYQHKFHVPA-KDIPALQKDVIRCYVEGISWVLLYYYQGCASWTWYY 644
+ V+L + G+ +RYY+ KF + +++ +++DV+ Y EG+ W++ YYY G SW W+Y
Sbjct: 521 DKVKLNKVGWRERYYEEKFAAKSVEEMEQIRRDVVLKYTEGLCWIMHYYYHGVCSWNWFY 580
Query: 645 PYHYAPFAQDFKNIKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRPLMSDPNSEI 704
PYHYAPFA D K ++ LDI F+LG PF P+ QL++VLP+AS HALPE +R LM++P+S I
Sbjct: 581 PYHYAPFASDLKGLEKLDIKFELGSPFKPFNQLLAVLPSASAHALPECYRSLMTNPDSPI 640
Query: 705 IDFYPEEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARNVRKKDALL 764
DFYP +F +DMNGK+ +WQGI+ LPF++E RLL+ + L++ E RN D L
Sbjct: 641 ADFYPADFEIDMNGKRYSWQGISKLPFVEEKRLLEAAAQVEKSLTNEEIRRNSALFDMLF 700
Query: 765 ISNKNVNYDLF------MKNLYGENPVNVIE--FRHFKSGLSGFVTQAEEGFELNSKLIC 816
+ + +L NL E +IE G++G++ A G + C
Sbjct: 701 VVASHPLGELIRSLNSRTNNLSNEERATIIEKIDPGLSDGMNGYI--ASCGGDSQPSCFC 758
Query: 817 PINGGGLPDLSTNLFLKLSYTQP 839
G+ D+ TN + Y P
Sbjct: 759 S-TVEGMEDVLTNQVICAIYKLP 780
>At1g54490 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 947
Score = 375 bits (962), Expect = e-103
Identities = 196/423 (46%), Positives = 275/423 (64%), Gaps = 15/423 (3%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIED-GVQLPLDYSSANPNG-ELDNLYLDMNGIV 58
MGVP+F+RWL+ +YPK IS V+EE P G +P+D + NPNG E DNLYLDMNGI+
Sbjct: 1 MGVPAFYRWLADRYPKSISDVVEEEPTDGGRGDLIPVDITRPNPNGFEFDNLYLDMNGII 60
Query: 59 HPCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRF 118
HPC HPE KP P T D++ ++FEY + + + RPRK+L +A+DGVAPRAKMNQQR+RRF
Sbjct: 61 HPCFHPEGKPAPATYDDVFKSMFEYIDHLFTLVRPRKILYLAIDGVAPRAKMNQQRSRRF 120
Query: 119 RSARDAKLQNEAREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKLATALRYWT 178
R+A+DA E++ ++ E G+ + K++ T DSN ITPGTPFM L+ AL+Y+
Sbjct: 121 RAAKDAAEAEAEEERLRKDFEMEGQILSAKEKAE-TCDSNVITPGTPFMAILSVALQYYI 179
Query: 179 SFKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDADLIF 238
+L +PGW+ +++I+SD+ VPGEGEHKIM++IR QR ++PNT HC+YGLDADLI
Sbjct: 180 QSRLNHNPGWRYVKVILSDSNVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLIM 239
Query: 239 LGLATHEPHFKILREDVFANNNYKK--------PKPQDMINLSEEEKQQLIQQDSEKPFL 290
L LATHE HF ILRE + +K D S +K +
Sbjct: 240 LSLATHEVHFSILREVITYPGQQEKCFVCGQTGHFASDCPGKSGSNNAAADIPIHKKKYQ 299
Query: 291 WLHISVLREYLSAELAIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDI 350
+L+I VLREYL ELAIP F +FER IDD+VF+CFF GNDFLPH+P L++RE +I++
Sbjct: 300 FLNIWVLREYLQYELAIPDPPFMINFERIIDDFVFLCFFVGNDFLPHMPTLEIREGAINL 359
Query: 351 LVDIWKTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQEVRKQEAHDRRK 410
L+ +++ YLT G + L+ VE ++ + E +F+K+ R +++ D +
Sbjct: 360 LMHVYRKEFTAMGGYLTDSGEVLLDRVEHFIQAVAVNEDKIFQKR----TRIKQSMDNNE 415
Query: 411 KLK 413
++K
Sbjct: 416 EMK 418
Score = 210 bits (534), Expect = 1e-53
Identities = 117/288 (40%), Positives = 170/288 (58%), Gaps = 13/288 (4%)
Query: 585 DESVRLYEPGYHDRYYQHKFHVP-AKDIPALQKDVIRCYVEGISWVLLYYYQGCASWTWY 643
D+ ++L EPGY +RYY KF ++ +++D++ YVEG+ WV YYYQG SW W+
Sbjct: 434 DDKIKLGEPGYKERYYAEKFSTTNPEETEQIKQDMVLKYVEGLCWVCRYYYQGVCSWQWF 493
Query: 644 YPYHYAPFAQDFKNIKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRPLMSDPNSE 703
YPYHYAPFA D KN+ +L+I F +GEPF P++QLM LPAAS +ALP +R LM+DP+S
Sbjct: 494 YPYHYAPFASDLKNLPDLEITFFIGEPFKPFDQLMGTLPAASSNALPGEYRKLMTDPSSP 553
Query: 704 IIDFYPEEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARNVRKKDAL 763
I+ FYP +F +DMNGK+ AWQGIA LPFI+E LL R+ L+ E+ RN D L
Sbjct: 554 ILKFYPADFELDMNGKRFAWQGIAKLPFIEEKLLLAATRKLEETLTVEEQQRNSVMLDLL 613
Query: 764 LI------SNKNVNYDLFMKNLYGENPVNVIEFRHFKSGLSGFVTQAE-EGFELNSKLIC 816
+ + + Y F +++ + + + G++GF+ +E GF+ +++
Sbjct: 614 YVHPAHPLGQRILQYYHFYQHMPPHECLPWMIDPNSSQGMNGFLWFSERNGFQ--TRVDS 671
Query: 817 PINGGGLPDLSTNLFLKLSYTQPVVAGRCKSLVLNGYIPPQPMLTPQD 864
P+N GLP + N L ++Y P S G I P +LT D
Sbjct: 672 PVN--GLPCIEQNRALNVTYLCPAKHSHI-SEPPRGAIIPDKILTSVD 716
>7297186 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 885
Score = 363 bits (933), Expect = e-100
Identities = 206/489 (42%), Positives = 295/489 (60%), Gaps = 61/489 (12%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIED-GVQLPLDYSSANPNG-ELDNLYLDMNGIV 58
MGVP+FFRWLSRKYP +I E V D G + D + NPNG E DNLYLDMNGI+
Sbjct: 1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGII 60
Query: 59 HPCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRF 118
HPC+HPE+KP P+ EDEM++A+FE +R+ + RPRK+L +A+DGVAPRAKMNQQR+RRF
Sbjct: 61 HPCTHPEDKPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRF 120
Query: 119 RSARDAKLQNEAREQVLREREDY---GETIDENVKSKKTWDSNAITPGTPFMDKLATALR 175
R+A++ E R ++ R RE+ G + + + +DSN ITPGTPFMD+L+ L
Sbjct: 121 RAAKET---TEKRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLH 177
Query: 176 YWTSFKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDAD 235
Y+ + +P WK +++I+SDA VPGE H + G DAD
Sbjct: 178 YFVHDRQNNNPAWKGIKVILSDANVPGE-----------------------HVLCGADAD 214
Query: 236 LIFLGLATHEPHFKILREDVFANNNYKKPKPQDMINLSEEEKQQLIQQDSEKP------- 288
LI LGLATHEP+F I+RE+ N KP+P D+ N E + + + P
Sbjct: 215 LIMLGLATHEPNFTIIREEFLPN----KPRPCDICNGFGHEMDKCVGLGATAPTSANFKP 270
Query: 289 ---------FLWLHISVLREYLSAELAIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLP 339
F+++ +SVLREYL L +P+L F++ FERA+DDWVFMCFF GNDFLPHLP
Sbjct: 271 DVPIGAEVKFIFVRLSVLREYLKQTLEMPNLPFEYSFERALDDWVFMCFFVGNDFLPHLP 330
Query: 340 CLDVRENSIDILVDIWKTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQE 399
L++RE ++D LV+++K + KT+ YLT G +NL+ V+ ++ LG+ E +FK + +E
Sbjct: 331 SLEIREGAVDRLVELYKKCVYKTRGYLTDSGDVNLDRVQLIMTDLGNAEDQIFKSRQRRE 390
Query: 400 VR---KQEAHDRRKKLKSNPNVSQGKVDRNFMIPLENMPVYDVDGNAAEGSLNLSNK--- 453
+ + +A R+++ + + +++Q + + P N V GN E + L N+
Sbjct: 391 EQFKARDKARKRQERNQDHGSLNQSAFGASAVGP--NSQQRSV-GNYKEEAAALRNRKRT 447
Query: 454 -DFANMRKE 461
D AN+ E
Sbjct: 448 SDMANLDDE 456
Score = 221 bits (562), Expect = 6e-57
Identities = 118/258 (45%), Positives = 162/258 (62%), Gaps = 6/258 (2%)
Query: 583 DTDESVRLYEPGYHDRYYQHKFHVPAKDIPALQKDVIRCYVEGISWVLLYYYQGCASWTW 642
+ ++ VRL+E G+ DRYY+ KF V A + V YV G+ WVL YYYQGCASW W
Sbjct: 460 ENNDEVRLWEDGFKDRYYESKFDV-APGNQQFRYAVALQYVRGLCWVLKYYYQGCASWNW 518
Query: 643 YYPYHYAPFAQDFKNIKNLDIHFDLG-EPFLPYEQLMSVLPAASGHALPEIFRPLMSDPN 701
Y+PYHYAPFA DF NI+ L F+ G +PF P EQLM V PAAS +PE + LMSDP
Sbjct: 519 YFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPLEQLMGVFPAASSSHVPEPWAKLMSDPE 578
Query: 702 SEIIDFYPEEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARNVRKKD 761
S IIDFYPE+F +D+NGKK AWQG+ALLPF+DE RL K + Y +L+ E RN R +
Sbjct: 579 SPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDN 638
Query: 762 ALLISNKNVNYDLFMKNLYGENPVNVIEFRHFKSGLSGFVTQAEEGFELNSKLICPINGG 821
L ISN++ +Y +K + ++ +V + F G+ G + + E ++ L PI+
Sbjct: 639 YLYISNQSPHYKK-VKKISEKDDESVCKAISF-DGMRGTLGKTELNTAISGVLKSPIS-- 694
Query: 822 GLPDLSTNLFLKLSYTQP 839
GL D++ N+ + ++ P
Sbjct: 695 GLSDINDNITVTTTFRDP 712
>CE26838 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA
strand exchange and mRNA turnover
Length = 1209
Score = 308 bits (789), Expect = 3e-83
Identities = 176/411 (42%), Positives = 238/411 (57%), Gaps = 42/411 (10%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIEDGVQLPLDYSSANPNGELDNLYLDMNGIVHP 60
MGVP F+RW S +YP +S V+ E Q+P E DNLYLDMNGI+H
Sbjct: 1 MGVPKFYRWTSERYP-CLSEVINES-------QIP----------EFDNLYLDMNGIIHN 42
Query: 61 CSHPENKPPPE--TEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRF 118
CSHP + TEDE+ + +F Y + N+ RP+KV +AVDGVAPRAKMNQQRARRF
Sbjct: 43 CSHPNDDDVTFRITEDEIFVNIFAYIENLYNLIRPQKVFFMAVDGVAPRAKMNQQRARRF 102
Query: 119 RSARDAKLQNE--------AREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKL 170
+ L + A Q+ + E+ E + S+ +DSN ITPGT FM +L
Sbjct: 103 MYVEELLLAGKKEIWSARTAHTQLAKALEN-----GEIMPSEARFDSNCITPGTYFMTRL 157
Query: 171 ATALRYWTSFKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIY 230
L W K ATD W+ +II+S VPGEGEHKIM+FIR++RA + Y+PNT HC+Y
Sbjct: 158 HQKLDDWIKTKSATDSRWQGRKIILSGHNVPGEGEHKIMDFIRTERAGSSYDPNTRHCMY 217
Query: 231 GLDADLIFLGLATHEPHFKILREDVFANNNYKKPKPQDMINLSEEEKQQLIQQDSEKPFL 290
GLDADLI LG+ +HEPHF +LRE+V N +K N ++ K+ K F
Sbjct: 218 GLDADLIMLGIVSHEPHFSLLREEVTFNTRPRK-------NDNKATKKPKRTDSDVKKFH 270
Query: 291 WLHISVLREYLSAELA--IPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLDVRENSI 348
LH+S+LREYL+ E A L F+++ ER +DDW+ + GNDFLPHLP + + ++++
Sbjct: 271 LLHLSLLREYLAWEFADVKDSLPFEYEMERIVDDWILLGLLVGNDFLPHLPNIHIHDDAL 330
Query: 349 DILVDIWKTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKKKYIQE 399
+L +K VLP Y+ G LNL EA L +L + F ++ E
Sbjct: 331 PLLYSTYKKVLPTLDGYINEAGYLNLSRFEAFLAELALNDKTSFMERLEDE 381
Score = 152 bits (384), Expect = 2e-36
Identities = 75/161 (46%), Positives = 99/161 (60%), Gaps = 5/161 (3%)
Query: 599 YYQHKFHVPAKDIPALQ-KDVIRCYVEGISWVLLYYYQGCASWTWYYPYHYAPFAQDFKN 657
YY K K+I Q ++ YV I W L YYY GC SW+W+YP+HYAPF D +
Sbjct: 513 YYSDKLRY--KNISKQQLREQAEGYVRAIQWNLHYYYHGCVSWSWFYPHHYAPFISDVRG 570
Query: 658 IKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRPLM-SDP-NSEIIDFYPEEFPVD 715
+ + F+L EPF P+EQL++VLP AS LP R LM SDP S I DFYP F D
Sbjct: 571 FVGMRMEFELSEPFHPFEQLLAVLPEASADCLPRPLRELMSSDPAKSPICDFYPANFETD 630
Query: 716 MNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARN 756
+NGK+ W+ + L+PFI+E RLL+ + + S+L+ E ARN
Sbjct: 631 LNGKRNEWEAVVLIPFIEEKRLLEAIEAKRSRLTSEENARN 671
>7293586 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA
strand exchange and mRNA turnover
Length = 1612
Score = 286 bits (731), Expect = 1e-76
Identities = 167/417 (40%), Positives = 231/417 (55%), Gaps = 62/417 (14%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIEDGVQLPLDYSSANPNGELDNLYLDMNGIVHP 60
MGVP FFR++S +YP +S + E+ + E DNLYLDMNGIVH
Sbjct: 1 MGVPKFFRYISERYP-CLSELAREHCI-----------------PEFDNLYLDMNGIVHN 42
Query: 61 CSHPE--NKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRF 118
CSHP+ N E+++ +F Y +++ + +P+++ ++VDGVAPRAKMNQQR+RRF
Sbjct: 43 CSHPDDNNIHFHLEEEQIFQEIFNYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRF 102
Query: 119 RSARDAKLQNE--AREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKLATALRY 176
R+AR+A+ Q A+ LRE E + DSN ITPGT FM +L LR
Sbjct: 103 RTAREAEQQEAKAAQRGELREHERF--------------DSNCITPGTEFMVRLQEGLRA 148
Query: 177 WTSFKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDADL 236
+ K++TDP W+ +I+S PGEGEHKIM++IR + Y+PNT HC+YGLDADL
Sbjct: 149 FLKTKISTDPLWQRCTVILSGQEAPGEGEHKIMDYIRYMKTQPDYDPNTRHCLYGLDADL 208
Query: 237 IFLGLATHEPHFKILREDVFANNNYKKPKPQDMINLSEEEKQQLIQQDSEKPFLWLHISV 296
I LGL THE HF +LRE+V N K+ + E F LH+ +
Sbjct: 209 IILGLCTHELHFVVLREEVKFGRNVKRTSVE------------------ETRFFLLHLGL 250
Query: 297 LREYLSAEL-AIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILVDIW 355
LREYL E A+ + D + IDDWV M F GNDF+PHLPCL + N++ +L +
Sbjct: 251 LREYLELEFDALRTDEHKLDIAQLIDDWVLMGFLVGNDFIPHLPCLHISSNALPLLYRTY 310
Query: 356 KTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKK-----KYIQEVRKQEAHD 407
+ P + +G LNL ++ + L + E D FK+ KY+ K EA D
Sbjct: 311 IGIYPTLGGNINENGKLNLRRLQIFISALTEVELDHFKEHADDLKYMN--NKSEAFD 365
Score = 159 bits (402), Expect = 2e-38
Identities = 75/162 (46%), Positives = 103/162 (63%), Gaps = 2/162 (1%)
Query: 595 YHDRYYQHKFHVPAKDIPALQKDVIRCYVEGISWVLLYYYQGCASWTWYYPYHYAPFAQD 654
Y +Y++KF D L +++ YV + WVL YYY+G SW WYYP+HY PF D
Sbjct: 414 YKRNFYRNKFKRDPND--ELIEELCHHYVNALQWVLDYYYRGVQSWDWYYPFHYTPFISD 471
Query: 655 FKNIKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRPLMSDPNSEIIDFYPEEFPV 714
KNI+ ++I F +G PFLP++QL++VLPAAS LP + LM P S + +FYP EF
Sbjct: 472 LKNIEQVEIAFHMGTPFLPFQQLLAVLPAASAKLLPVAYHDLMLLPTSPLAEFYPLEFES 531
Query: 715 DMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARN 756
D+NGKK W+ + L+PFIDE RLL + ++LS E+ RN
Sbjct: 532 DLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQLSLEERERN 573
>YGL173c [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA
strand exchange and mRNA turnover
Length = 1528
Score = 285 bits (728), Expect = 3e-76
Identities = 162/399 (40%), Positives = 232/399 (57%), Gaps = 52/399 (13%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIEDGVQLPLDYSSANPNGELDNLYLDMNGIVHP 60
MG+P FFR++S ++P I+ + +G Q+P E DNLYLDMN I+H
Sbjct: 1 MGIPKFFRYISERWPMILQLI--------EGTQIP----------EFDNLYLDMNSILHN 42
Query: 61 CSHPENKPPPE--TEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRF 118
C+H + + TE+E+ + Y + + +P+K+ +A+DGVAPRAKMNQQRARRF
Sbjct: 43 CTHGNDDDVTKRLTEEEVFAKICTYIDHLFQTIKPKKIFYMAIDGVAPRAKMNQQRARRF 102
Query: 119 RSARDAKLQNEAREQVLREREDYGETIDENVKSKKTWDSNAITPGTPFMDKLATALRYWT 178
R+A DA E+ L++ + G+ I + + +DSN+ITPGT FM KL L+Y+
Sbjct: 103 RTAMDA-------EKALKKAIENGDEIPKG----EPFDSNSITPGTEFMAKLTKNLQYFI 151
Query: 179 SFKLATDPGWKNLQIIISDATVPGEGEHKIMNFIRSQRADTQYNPNTTHCIYGLDADLIF 238
K++ D W+ +QII S VPGEGEHKIMNFIR ++ +N NT HCIYGLDADLI
Sbjct: 152 HDKISNDSKWREVQIIFSGHEVPGEGEHKIMNFIRHLKSQKDFNQNTRHCIYGLDADLIM 211
Query: 239 LGLATHEPHFKILREDV-FANNNYKKPKPQDMINLSEEEKQQLIQQDSEKPFLWLHISVL 297
LGL+TH PHF +LRE+V F N EK+ L Q+ F LH+S+L
Sbjct: 212 LGLSTHGPHFALLREEVTFGRRN--------------SEKKSLEHQN----FYLLHLSLL 253
Query: 298 REYLSAEL--AIPHLSFQFDFERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILVDIW 355
REY+ E + F+++FER +DD++ + F GNDFLP+LP L + + + +L+ +
Sbjct: 254 REYMELEFKEIADEMQFEYNFERILDDFILVMFVIGNDFLPNLPDLHLNKGAFPVLLQTF 313
Query: 356 KTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRETDLFKK 394
K L T Y+ G +NL+ + L L E F+K
Sbjct: 314 KEALLHTDGYINEHGKINLKRLGVWLNYLSQFELLNFEK 352
Score = 166 bits (420), Expect = 2e-40
Identities = 82/196 (41%), Positives = 116/196 (58%), Gaps = 6/196 (3%)
Query: 582 IDTDESVRLYEPGYHDRYYQHK---FHVPAK---DIPALQKDVIRCYVEGISWVLLYYYQ 635
++ E + + Y++R+ + K +H K D +D+ + YVEG+ WVL YYY+
Sbjct: 491 VEDKEELETEKTIYNERFERWKHEYYHDKLKFTTDSEEKVRDLAKDYVEGLQWVLYYYYR 550
Query: 636 GCASWTWYYPYHYAPFAQDFKNIKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRP 695
GC SW+WYYP+HYAP D + DI FDL +PF P++QLM+VLP S + +P FRP
Sbjct: 551 GCPSWSWYYPHHYAPRISDLAKGLDQDIEFDLSKPFTPFQQLMAVLPERSKNLIPPAFRP 610
Query: 696 LMSDPNSEIIDFYPEEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKAR 755
LM D S I DFYP E +D NGK W+ + L+ F+DE RL++ ++ KLS EK R
Sbjct: 611 LMYDEQSPIHDFYPAEVQLDKNGKTADWEAVVLISFVDEKRLIEAMQPYLRKLSPEEKTR 670
Query: 756 NVRKKDALLISNKNVN 771
N KD + N V+
Sbjct: 671 NQFGKDLIYSFNPQVD 686
>ECU09g0760 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 655
Score = 229 bits (583), Expect = 2e-59
Identities = 153/454 (33%), Positives = 231/454 (50%), Gaps = 64/454 (14%)
Query: 1 MGVPSFFRWLSRKYPKIISPVLEEYPVIEDGVQLPLDYSSANPNGELDNLYLDMNGIVHP 60
MGVPS FRWL + + I ++E+ V D LYLD N I+H
Sbjct: 1 MGVPSLFRWLQLSHKETIHSIMEKPSV--------------------DALYLDFNAIIHT 40
Query: 61 CSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLMIAVDGVAPRAKMNQQRARRFRS 120
C P E E ++ V ++ + +L RPRK+L IAVDGVAPRAK++ QRARR++S
Sbjct: 41 CIKPGLGSEEEIERDLYKTVGDFIDHILLKTRPRKLLYIAVDGVAPRAKLSHQRARRYKS 100
Query: 121 ARDAK----------------LQNEAREQVLRER-------------EDYGET--IDENV 149
A K +E ++++ E ED E+ + +V
Sbjct: 101 ALGKKEGSAVIAAAKADPTMSSPSEKKDEIPNEEFTGESSLYDKFIAEDPSESSSLAIDV 160
Query: 150 KSKKTWDSNAITPGTPFMDKLATALRYWTSFKLATDPGWKNLQIIISDATVPGEGEHKIM 209
+++K +D N ITPGTPFM++L L + KL++DP NL+II S VPGEGE KIM
Sbjct: 161 ETEK-FDLNCITPGTPFMERLHKVLISYIQCKLSSDPEVSNLRIIYSSYLVPGEGEQKIM 219
Query: 210 NFIRSQRADTQYNPNTTHCIYGLDADLIFLGLATHEPHFKILREDVFANNNYKKPKPQDM 269
+FIRSQ + + N H IY D DLIFLGL+ I+R D F+ + ++ +
Sbjct: 220 SFIRSQGSIAR---NDVHMIYSPDGDLIFLGLSLQRNRVLIMR-DYFSPSKERRKRTCTK 275
Query: 270 INLSEEEKQQLIQQDSEKPFLWLHISVLREYLSAELAIPHLSFQFDFERAIDDWVFMCFF 329
+ ++ + F++++IS LR L E H + +F ER +DDW+F+CF
Sbjct: 276 CGRTGHSDEEC-GVFTNYHFVYVNISELRTRLIREFR-RHTAQRFSEERILDDWIFLCFL 333
Query: 330 CGNDFLPHLPCLDVRENSIDILVDIWKTVLPKTKTYLTCDGTLNLEPVEALLEQLGDRET 389
GNDF+P +PCLD+R +SI+ + +I + K+Y+TC+ +N + + L +E
Sbjct: 334 LGNDFVPPIPCLDIRFHSIETITEIMMKSFSEMKSYITCNKMINYQALRNFYAILASKED 393
Query: 390 DLFKKKYIQEVRKQEAHDRRKKLKSNPNVSQGKV 423
L+ +K Q R+ LK P + K+
Sbjct: 394 GLYHRK------SQSLDKFREGLKGMPRIVYEKI 421
Score = 117 bits (293), Expect = 9e-26
Identities = 64/172 (37%), Positives = 89/172 (51%), Gaps = 9/172 (5%)
Query: 598 RYYQHKFHVPAK-DIPALQKDVIRCYVEGISWVLLYYYQGCASWTWYYPYHYAPFAQDFK 656
+YY K + + DI K++ YV+G+ WV YY G W WYYPYH+AP A D
Sbjct: 431 QYYTSKLNATTESDI----KNICYEYVKGLYWVYSYYVLGWTGWDWYYPYHFAPLAADLS 486
Query: 657 NIKNLDIHFDLGEPFLPYEQLMSVLPAASGHALPEIFRPLMSDPNSEIIDFYPEEFPVDM 716
+ DI G P P EQL+ VLP S +PE +P+ D D+YPE+ DM
Sbjct: 487 KLSINDIQISPGHPLRPLEQLLVVLPPMSRGMVPEGLQPIFDDYK----DYYPEDVKTDM 542
Query: 717 NGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARNVRKKDALLISNK 768
K WQ I LLPF+D +L +++ L + +RN+R D L ++K
Sbjct: 543 FDKVYLWQEIVLLPFMDFRPILSENAVKFNTLGYEDLSRNLRSLDLLFTTDK 594
>Hs22041601 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA
strand exchange and mRNA turnover
Length = 935
Score = 56.2 bits (134), Expect = 2e-07
Identities = 25/60 (41%), Positives = 39/60 (64%), Gaps = 1/60 (1%)
Query: 697 MSDPNSEIIDFYPEEFPVDMNGKKMAWQGIALLPFIDETRLLKTVREQYSKLSDSEKARN 756
M++ +S II++YP +F D+NGK+ W+ + L+PFIDE RLL+ + L E+ RN
Sbjct: 1 MTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDE-RLLEAMETCNHSLKKEERKRN 59
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.136 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,078,650
Number of Sequences: 60738
Number of extensions: 2741038
Number of successful extensions: 7946
Number of sequences better than 1.0e-05: 14
Number of HSP's better than 0.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 7852
Number of HSP's gapped (non-prelim): 29
length of query: 992
length of database: 30,389,216
effective HSP length: 116
effective length of query: 876
effective length of database: 23,343,608
effective search space: 20449000608
effective search space used: 20449000608
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)