ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI2288 good T KOG2595 Signal transduction mechanisms Predicted GTPase activator protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI2288 818541 819728 396
(396 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YFL027c [T] KOG2595 Predicted GTPase activator protein 202 5e-52
Hs21389447 [T] KOG2595 Predicted GTPase activator protein 94 5e-19
SPBC651.03c [T] KOG2595 Predicted GTPase activator protein 88 2e-17
7289454 [T] KOG2595 Predicted GTPase activator protein 83 8e-16
CE20311 [T] KOG2595 Predicted GTPase activator protein 62 2e-09
>YFL027c [T] KOG2595 Predicted GTPase activator protein
Length = 497
Score = 202 bits (515), Expect = 5e-52
Identities = 122/344 (35%), Positives = 183/344 (52%), Gaps = 31/344 (9%)
Query: 12 MASLSFISDLNQSKLKRVIVANALQNEDLASLEHLGTSRFGFVNSQLRSQAWLSILQSRV 71
+ SLS + K +++ L+ +D+ +L ++G GFVN+ LR W +L S++
Sbjct: 28 LESLSRCDSGKAEEQKGKVISKLLEKKDVRALRYIGLGPLGFVNNSLRKDCWYELLASQL 87
Query: 72 KGSHACGSLK--EPHKDEYQVNLDVNRSFSFIKDSSEKLQLRDLLYDTIVKTLRKFPQLN 129
A + E HKDE QV LD RSF I D + KLQLR LL + I + LRK+P LN
Sbjct: 88 LIDDATEYITPVEKHKDEGQVILDAERSFGGIVDKNLKLQLRKLLVELITRVLRKYPTLN 147
Query: 130 YYQGYHEVVSVFVLV---------------------CDRDSLNETVELFTLLYLRDYMMD 168
YYQGYH++VSVF++ D + L +E FTLLYLRD+MM+
Sbjct: 148 YYQGYHDIVSVFIMCFSWNVTKENGLELENLSLQEEIDMERLFYCIEAFTLLYLRDFMMN 207
Query: 169 SLQCTLEQLEVLSQFIMERDADLAKILQLNQKKPIFAIASVLTLLIHNFENFEEDSP--- 225
SL + EQL V+S I E + + + ++ +P+FAI S+LT+ HN + +
Sbjct: 208 SLDFSFEQLRVISSLIKESNMKFYNLFKFDENEPLFAIGSILTIFAHNLKPIDSGDNNLH 267
Query: 226 --IFSIFDIVITTNNLSNLFVVYTELLIYFKVPILKQVEAYEIDFENDMDLIHSVVQQTL 283
+F IFD+ I+ ++ ++Y LL+ I KQ+EA FEND DL H +Q L
Sbjct: 268 KILFQIFDMTISMQSMRLPLIIYKNLLLQNASEISKQIEANSDFFENDFDLRHGAIQTVL 327
Query: 284 LKFL-TRSSWDEILTQARLRLNNSTVRVAKYV--NKYSSLISVS 324
K L + W+E+L R ++ + K V NKYS+L++ +
Sbjct: 328 QKKLYDEALWEEVLQITRKDATTASKKALKRVSLNKYSALLNTA 371
>Hs21389447 [T] KOG2595 Predicted GTPase activator protein
Length = 403
Score = 93.6 bits (231), Expect = 5e-19
Identities = 73/271 (26%), Positives = 126/271 (45%), Gaps = 20/271 (7%)
Query: 19 SDLNQSKLKRVI-VANALQNE--DLASLEHLGTSRFGFVNSQLRSQAWLSILQSRVKGSH 75
+D N + K+V + AL ++ D+A+L + S G + ++R + W +L
Sbjct: 23 ADFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPKLLNVNANDPP 82
Query: 76 ACG--SLKEPHKDEYQVNLDVNRSFSFIKDSSEKLQ---LRDLLYDTIVKTLRKFPQLNY 130
+L++ KD QV LDV RS + Q L++ L D I+ L + PQL+Y
Sbjct: 83 PISGKNLRQMSKDYQQVLLDVRRSLRRFPPGMPEEQREGLQEELIDIILLILERNPQLHY 142
Query: 131 YQGYHEVVSVFVLVCDRDSLNETVELFTLLYLRDYMMDSLQCTLEQLEVLSQFIMERDAD 190
YQGYH++V F+LV VE + +LRD+M ++ T L L I + + +
Sbjct: 143 YQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDQVNPE 202
Query: 191 LAKILQLNQKKPIFAIASVLTLLIHNFENFEEDSPIFSIFDIVITTNNLSNLFVVYTELL 250
L +Q + IFA++ ++T H +F + ++D + + L +
Sbjct: 203 LHDFMQSAEVGTIFALSWLITWFGHVLSDFRH---VVRLYDFFLACHPL---------MP 250
Query: 251 IYFKVPILKQVEAYEIDFENDMDLIHSVVQQ 281
IYF I+ E +D + DM +H ++ Q
Sbjct: 251 IYFAAVIVLYREQEVLDCDCDMASVHHLLSQ 281
>SPBC651.03c [T] KOG2595 Predicted GTPase activator protein
Length = 373
Score = 88.2 bits (217), Expect = 2e-17
Identities = 68/249 (27%), Positives = 120/249 (47%), Gaps = 15/249 (6%)
Query: 34 ALQNEDLASLEHLGTSRFGFVNSQLRSQAWLSILQSRVKGSHAC---GSLKEPHKDEYQV 90
AL N D+ +L H+G GF+ LR W+S+ + C + + + D+ QV
Sbjct: 16 ALLNSDVETLSHIGKEGHGFLMKSLRKSVWVSLCGLSCRHRMECLSRSTSQSSYADQNQV 75
Query: 91 NLDVNRSFSFIKDSSEKLQL-RDLLYDTIVKTLRKFPQLNYYQGYHEVVSVFVLVCDRDS 149
+LD RSF K + L+ R L + + +P+L YYQG H++ + +L
Sbjct: 76 HLDSERSFFQYKLNPFLLRKHRSQLTKLLSVVFKHYPELCYYQGLHDIAQILLLTLPFSH 135
Query: 150 LNETVELFTLLYLRDYMMDSLQCTLEQLEVLSQFIMERDADLAKILQLNQKKPIFAIASV 209
+E LRD+M+ +L T++QL+++ I RD L + L + FA++ +
Sbjct: 136 ALPLMEHLVFYRLRDFMLPTLDGTVKQLQLILAVIKARDPTLYEYLIKADIQCYFALSWL 195
Query: 210 LTLLIHNFENFEEDSPIFSIFDIVITTNNLSNLFVVYTELLIYFKVPILKQVEAYEIDFE 269
+T H+ + S + +FD I+++ L+ VVYT +V + + E+ ++
Sbjct: 196 ITWFAHDVSDI---SVVCRLFDFFISSHPLT---VVYT----CAQVVLDNRTSIIELLWD 245
Query: 270 ND-MDLIHS 277
N DL+HS
Sbjct: 246 NSGADLLHS 254
>7289454 [T] KOG2595 Predicted GTPase activator protein
Length = 378
Score = 82.8 bits (203), Expect = 8e-16
Identities = 78/348 (22%), Positives = 156/348 (44%), Gaps = 44/348 (12%)
Query: 25 KLKRVIVANALQNEDLASLEHLGTSRFGFVNSQLRSQAWLSILQSRVKGSHACGSLK--E 82
+++++I N +N L L + +G VN R W + + +L +
Sbjct: 26 EIEKLINKNIDKNISFDVLVKLSLAPYGLVNDDFRRILWPQLAGVDINHLGQAPTLDKFQ 85
Query: 83 PHKDEYQVNLDVNRSFSFIKDS---SEKLQLRDLLYDTIVKTLRKFPQLNYYQGYHEVVS 139
H + QV LDVNRS +++ L+D L I++ ++K+P L YYQGYH+V
Sbjct: 86 CHPEYNQVVLDVNRSLKRFPPGIPYEQRIALQDQLTVLILRVIQKYPNLRYYQGYHDVAV 145
Query: 140 VFVLVCDRDSLNETVELFTLLYLRDYMMDSLQCTLEQLEVLSQFIMERDADLAKILQLNQ 199
F+LV + +E + + + M ++++ T +L + I + +L + LQ +
Sbjct: 146 TFLLVVGEEIAFAIMEQLSTTHFSECMQETMEATQRRLMFIWPIIKFENPELYQFLQNST 205
Query: 200 KKPIFAIASVLTLLIHNFENFEEDSPIFSIFDIVITTNNLSNLFVVYTELLIYFKVPILK 259
+F++ LT H+ ++ + ++D + + +++FV +L+Y ILK
Sbjct: 206 VGTLFSLPWYLTWFGHSLTSYR---TVVRLYDYFLASPIYTSIFVT-AAILLYRSDEILK 261
Query: 260 QVEAYEIDFENDMDLIH---SVVQQTLLKFLTRSSWDEILTQARLRLNNSTVRVAKYVNK 316
+ + DM +H SV+ + L ++++L + + +NK
Sbjct: 262 E--------DCDMASVHCLLSVIPEDL-------PFEDLLKTS-----------SSLLNK 295
Query: 317 YSSLISVSNIEFSELINVLSKEIEWDASRKIVKASP----KIPLFVKW 360
YS + ++E ELI ++ + D + + + P +IP+ KW
Sbjct: 296 YSLTLIEKDVE--ELICQERRKRKTDEALIVKRRQPATSNRIPIITKW 341
>CE20311 [T] KOG2595 Predicted GTPase activator protein
Length = 430
Score = 61.6 bits (148), Expect = 2e-09
Identities = 63/290 (21%), Positives = 126/290 (42%), Gaps = 31/290 (10%)
Query: 10 FDMASLSFISDLNQSKLKRVIVANALQNEDLASLEHLGTSRFGFVNSQLRSQAWLSILQS 69
F ++ + D ++ + V+ AN +QN+DL + S F S + +
Sbjct: 75 FAISPGGLVDDEFRAVIWPVLSANLVQNDDLDDVSSSYDSDFESAQSDFDEEPAYEVFTL 134
Query: 70 RVKGSHACGSLK------------EPHKDEYQVNLDVNRSFSF----IKDSSEKLQLRDL 113
+ + L + HK+ QV LDV+R+ S I D+ + L+
Sbjct: 135 NINFLNMKYKLVFQESEELTLEDLKGHKEWNQVELDVHRTLSRFPPNISDTHRDV-LQTE 193
Query: 114 LYDTIVKTLRKFPQLNYYQGYHEVVSVFVLVC-DRDSLNETVELFTLLYLRDYMMDSLQ- 171
L IV+ L P+ NYYQG+H++ +LVC + D+L L +Y++ +L+
Sbjct: 194 LIPLIVRVLSINPRFNYYQGFHDICLTVLLVCGEVDALPVCSNLAKNGSFNNYLLKTLEK 253
Query: 172 CTLEQLEVLSQFIMERDADLAKILQLNQKKPIFAIASVLTLLIHNFENFEEDSPIFSIFD 231
+ +L++L + D L ++++ + +F ++ LT H + +++ I FD
Sbjct: 254 SVVRELDLLYVILSRVDPSLEQVMRSVELGTMFGLSWPLTWFSHTLKQYQQ---IVRFFD 310
Query: 232 IVITTNNLSNLFVVYTELLIYFKVPILKQVEAYEIDFENDMDLIHSVVQQ 281
+ + ++ L L IY ++ A + E +M +H ++ +
Sbjct: 311 VFLASSPL---------LPIYVSAAVVVFRRASILACEREMPFLHRLLTE 351
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.134 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,507,255
Number of Sequences: 60738
Number of extensions: 800786
Number of successful extensions: 2222
Number of sequences better than 1.0e-05: 5
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 2211
Number of HSP's gapped (non-prelim): 5
length of query: 396
length of database: 30,389,216
effective HSP length: 108
effective length of query: 288
effective length of database: 23,829,512
effective search space: 6862899456
effective search space used: 6862899456
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)