ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI2583 good U KOG0985 Intracellular trafficking, secretion, and vesicular transport Vesicle coat protein clathrin, heavy chain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI2583 916269 911308 -1654
(1654 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGL206c [U] KOG0985 Vesicle coat protein clathrin heavy chain 2576 0.0
SPAC26A3.05 [U] KOG0985 Vesicle coat protein clathrin heavy chain 1691 0.0
Hs4758012 [U] KOG0985 Vesicle coat protein clathrin heavy chain 1566 0.0
7293138 [U] KOG0985 Vesicle coat protein clathrin heavy chain 1552 0.0
Hs9257202 [U] KOG0985 Vesicle coat protein clathrin heavy chain 1507 0.0
CE00480 [U] KOG0985 Vesicle coat protein clathrin heavy chain 1489 0.0
Hs4502903 [U] KOG0985 Vesicle coat protein clathrin heavy chain 1427 0.0
At3g11130 [U] KOG0985 Vesicle coat protein clathrin heavy chain 1385 0.0
At3g08530 [U] KOG0985 Vesicle coat protein clathrin heavy chain 1267 0.0
Hs20561160 [U] KOG0985 Vesicle coat protein clathrin heavy chain 1081 0.0
Hs22042197 [U] KOG0985 Vesicle coat protein clathrin heavy chain 56 5e-07
>YGL206c [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1653
Score = 2576 bits (6678), Expect = 0.0
Identities = 1276/1655 (77%), Positives = 1462/1655 (88%), Gaps = 6/1655 (0%)
Query: 1 MSDLPIEFTELVDLTSLGISPQYLDFRSTTFESDHFVTVRESSNGTNTVAIVDLTNGNEV 60
MSDLPIEFTELVDL SLGISPQ+LDFRSTTFESDHFVTVRE+ +GTN+VAIVDL GNEV
Sbjct: 1 MSDLPIEFTELVDLMSLGISPQFLDFRSTTFESDHFVTVRETKDGTNSVAIVDLAKGNEV 60
Query: 61 TRKNMGGDSAIMHPSQKVISVRANGTIVQIFNLDTKSKLKSFQLDEPVIFWKWLSEDVLG 120
TRKNMGGDSAIMHPSQ VISVRANGTIVQIFNL+TKSKLKSF LDEPVIFW+WLSE LG
Sbjct: 61 TRKNMGGDSAIMHPSQMVISVRANGTIVQIFNLETKSKLKSFTLDEPVIFWRWLSETTLG 120
Query: 121 FITANSLYVSNVFDGNVSAKPAKITDRHVNLNNTQIINFVANEKMDWFAVVGIIQENGKI 180
F+TA S+ SNVFDGNV+AKP +T RH NLNNTQIINFVAN+ +DWFAVVGI+QENG+I
Sbjct: 121 FVTARSILTSNVFDGNVNAKPQLLTLRHANLNNTQIINFVANKNLDWFAVVGILQENGRI 180
Query: 181 AGKIQLFSKTRGISQAIDGHVAIFSKILLDGN-TEPVQVFVTGNRNVNTGAGELRIIEID 239
AG+IQLFSK R ISQAIDGHVAIF+ ILL+GN + PVQVFVTGNRN TGAGELRIIEID
Sbjct: 181 AGRIQLFSKQRNISQAIDGHVAIFTNILLEGNGSTPVQVFVTGNRNATTGAGELRIIEID 240
Query: 240 PPQDQSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLYELETGSNLF 299
+YQK+ DIFFP DA NDFPI+VQVSEKYGIIY+LTKYGFIHLYELETG+NLF
Sbjct: 241 HDASLPSQYQKETTDIFFPPDATNDFPIAVQVSEKYGIIYLLTKYGFIHLYELETGTNLF 300
Query: 300 VNRITADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNVSLALTMASR 359
VNRITA+SVFTA YNH+NGIACINKKG VLAVEI T+QIVPY+LNKLSNV+LAL +A+R
Sbjct: 301 VNRITAESVFTAAPYNHENGIACINKKGQVLAVEISTSQIVPYILNKLSNVALALIVATR 360
Query: 360 GGLPGADDLFEKQFDNLLSQGDYSNAAKVAASSQQLRTQATINKLKNIQAPPGSISPILL 419
GGLPGADDLF+KQF++LL Q DY NAAKVAASS LR Q TIN+LKNIQAPPG+ISPILL
Sbjct: 361 GGLPGADDLFQKQFESLLLQNDYQNAAKVAASSTSLRNQNTINRLKNIQAPPGAISPILL 420
Query: 420 YFSTLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPFDTTLAL 479
YFSTLLDKGKLN+ E+IEL RP+LQQ+R QL+EK+LKEDKL+CSEELGDIVKPFDTTLAL
Sbjct: 421 YFSTLLDKGKLNKEETIELARPVLQQDRKQLFEKWLKEDKLECSEELGDIVKPFDTTLAL 480
Query: 480 ATYLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLRTNPDKASEFAISL 539
A YL+A H KVI+CLAELQQF+KI+PY KVGY PNF+VLIS+L+R++PD+ASEFA+SL
Sbjct: 481 ACYLRAGAHAKVISCLAELQQFEKIIPYCQKVGYQPNFLVLISSLIRSSPDRASEFAVSL 540
Query: 540 LSNPETASQLEVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTRVLEINLLNAPQ 599
L NPETASQ+++EKIAD+FFSQN+IQQGTS LLDAL+ +TPDQGHLQTRVLE+NLL+APQ
Sbjct: 541 LQNPETASQIDIEKIADLFFSQNHIQQGTSLLLDALKGDTPDQGHLQTRVLEVNLLHAPQ 600
Query: 600 VADAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHTSSIPADWLVDF 659
VADAILGN+IFS+YDKPTIA L+EKAGLYQRALENY+DIKDIKRC+VHT+++P DWLV +
Sbjct: 601 VADAILGNNIFSHYDKPTIASLSEKAGLYQRALENYTDIKDIKRCVVHTNALPIDWLVGY 660
Query: 660 FGKLNVEQSLACLKTLLDDNLEANLQIVIQVATKFSDLIGSQVLIKLFEDYRSNEGLYYY 719
FGKLNVEQSLACLK L+D+N++AN+Q V+QVATKFSDLIG LIKLFEDY + EGLYYY
Sbjct: 661 FGKLNVEQSLACLKALMDNNIQANIQTVVQVATKFSDLIGPSTLIKLFEDYNATEGLYYY 720
Query: 720 LASLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFLKDAQLQDQMPL 779
LASLVNLT DK+VV+KYI+AA K ++E+ERIV++NNVYDPE+VKNFLKDA L+DQ+PL
Sbjct: 721 LASLVNLTEDKDVVYKYIEAAAKMKQYREIERIVKDNNVYDPERVKNFLKDANLEDQLPL 780
Query: 780 VVVCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVDCDEKVITSLLD 839
V+VCDRF+ VH+++LYLY+++N KFIE YVQQVNPSKTAQVV LLD+DCDE I SLL
Sbjct: 781 VIVCDRFDFVHEMILYLYKSQNLKFIETYVQQVNPSKTAQVVGALLDMDCDEAFIQSLLQ 840
Query: 840 TVVGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIYIDSNNSPEKFL 899
+V+GQVPI+ELT EVEKRNR G Q+Q+VYN LAKIYIDSNNSPEKFL
Sbjct: 841 SVLGQVPINELTTEVEKRNRLKILLPFLEQSLSQGIQDQAVYNALAKIYIDSNNSPEKFL 900
Query: 900 KENDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLARSNSD 959
KENDQYDTL+VG YCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLL RS+ D
Sbjct: 901 KENDQYDTLDVGHYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLERSDLD 960
Query: 960 LWNIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTXXXXXXXXXXXX 1019
LWN VL+ +NIHRRQL+D+VISVGIPELTDPEPVSLTVQAFM+NGLK
Sbjct: 961 LWNKVLNQENIHRRQLIDSVISVGIPELTDPEPVSLTVQAFMTNGLKLELIELLEKIILE 1020
Query: 1020 PSPFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENELNEEAFEIYDK 1079
PSPFN+N ALQGLLLLSAI+YEP KVS IEKLD+YD DEIAPLCIE++L EEAFEIYDK
Sbjct: 1021 PSPFNENVALQGLLLLSAIKYEPTKVSSYIEKLDNYDADEIAPLCIEHDLKEEAFEIYDK 1080
Query: 1080 HGKHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPEAIDSYIKAKDP 1139
H + KALKV++ED++ LDRA SYADKINTPELWSQ+GTA+L+ LRIP+AI+SYIKA+DP
Sbjct: 1081 HEMYGKALKVLIEDIMSLDRAASYADKINTPELWSQIGTAQLDGLRIPDAIESYIKAEDP 1140
Query: 1140 SNFMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKLNEIENLLSVST 1199
SN+ NVI AE AGK+EEL+P+LLMAR++LKEP IDGALILAYAEL+K++EIENLL+ S
Sbjct: 1141 SNYENVIDIAEQAGKYEELIPFLLMARKTLKEPKIDGALILAYAELNKIHEIENLLAGSN 1200
Query: 1200 VANLEEVGDKLSQHNDYKAAKLCYSSISNYSKLASTLVYLGDYQNAVDTARKASNVKVWR 1259
VANL+ VGDKL ++ +YKAA+LCYS++SNYSKLASTLVYLGDYQ AVDTARKASN+KVW+
Sbjct: 1201 VANLDHVGDKLFENKEYKAARLCYSAVSNYSKLASTLVYLGDYQAAVDTARKASNIKVWK 1260
Query: 1260 QVNDACISNKEFRLAQICGLNLVVHAEELDELVAVYEHNGYFEELISLFEAGLGLERAHM 1319
VNDACI KEF+LAQICGLNL+VHAEELDELV YE NGYFEELISLFEAGLGLERAHM
Sbjct: 1261 LVNDACIEKKEFKLAQICGLNLIVHAEELDELVERYESNGYFEELISLFEAGLGLERAHM 1320
Query: 1320 GMFTELAILYTKYNPSKTYEHLKLFWSRINIPKVIRAVEDAHLWPELIFLYAHYDEWDNA 1379
GMFTELAILY+KY P KT+EHLKLFWSRINIPKVIRAVE AHLW EL+FLYAHYDEWDNA
Sbjct: 1321 GMFTELAILYSKYEPDKTFEHLKLFWSRINIPKVIRAVEQAHLWSELVFLYAHYDEWDNA 1380
Query: 1380 ALTMIEKSAYNFDHSYFKEIIVKVSNLEIYYKAINFYVKEHPSLLVDLLTVLIPRLDIPR 1439
ALT+IEKS + DH+YFKE++VKVSNLEIYYKAINFYVK HPSLLVDLLT L PRLDIPR
Sbjct: 1381 ALTLIEKSTKDLDHAYFKEVVVKVSNLEIYYKAINFYVKFHPSLLVDLLTSLTPRLDIPR 1440
Query: 1440 TVRIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEVDYKALQDAVSSYDKFDQLE 1499
TV+IFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEE DYKALQDAV SYDKFDQL
Sbjct: 1441 TVKIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEEDYKALQDAVDSYDKFDQLG 1500
Query: 1500 LATRLENHEIIFFKIIAAELYRRNKKWAKSLAIFKGEQLWKHAIETAAISQSQQIAEDLL 1559
LA+RLE+H++IFFK I A LYRRNKKWAKSL+I K E+LWK AIETAAISQ ++ E LL
Sbjct: 1501 LASRLESHKLIFFKKIGALLYRRNKKWAKSLSILKEEKLWKDAIETAAISQDPKVVEALL 1560
Query: 1560 SFFIETDNKEGFIALLYSCYHLITYDTVLEQAWLNNLETFIKPYEISVKKEQNDAIKQLS 1619
++F+ET N+EGF+ALLY+ Y+L+ + VLE +W+N+LE +IKP+EIS+KKEQND+IK+++
Sbjct: 1561 TYFVETGNREGFVALLYAAYNLVRIEFVLEISWMNSLEDYIKPFEISIKKEQNDSIKKIT 1620
Query: 1620 SEFASKAKVGSN---SDDQPLLLTNGAIGSQATGF 1651
E A K+ GSN D QPL+L N A+ Q TGF
Sbjct: 1621 EELAKKS--GSNEEHKDGQPLMLMNSAMNVQPTGF 1653
>SPAC26A3.05 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1666
Score = 1691 bits (4378), Expect = 0.0
Identities = 846/1665 (50%), Positives = 1180/1665 (70%), Gaps = 29/1665 (1%)
Query: 4 LPIEFTELVDLTSLGISPQYLDFRSTTFESDHFVTVRESSNGTNTVAIVDLTNGNEVTRK 63
LPI F+E++ L S+GI P F + T ESD +V VR++ NG N V IVDL + + V R+
Sbjct: 5 LPIRFSEVLQLASVGIQPSSFGFANVTLESDKYVCVRDNPNGVNQVVIVDLEDPSNVLRR 64
Query: 64 NMGGDSAIMHPSQKVISVRANGTIVQIFNLDTKSKLKSFQLDEPVIFWKWLSEDVLGFIT 123
+ DS I+HP +K+I+++A + Q+F+L+ K+K+ S+ +++ V++W W+S+ V+G +T
Sbjct: 65 PISADSVILHPKKKIIALKAQRQL-QVFDLEAKAKINSYVMNQDVVYWTWISDSVIGMVT 123
Query: 124 ANSLYVSNVFDGNVSAK-PAKITDRHVNLNNTQIINFVANEKMDWFAVVGIIQENGKIAG 182
S VF VS P K+ DRH +LN TQII++ +N +WF ++GI + +IAG
Sbjct: 124 DTS-----VFHWTVSGSDPVKMFDRHSSLNGTQIISYKSNYNEEWFTLIGISSRDNRIAG 178
Query: 183 KIQLFSKTRGISQAIDGHVAIFSKILLDGNTEPVQVFVTGNRNVNTGAGELRIIEIDPPQ 242
+QL+SK R +SQ ++ H + F+ I +G VQV +R + TG+ +L I+E+D
Sbjct: 179 NLQLYSKKRKVSQPLESHASAFAVIQPEGVDHEVQVLALASR-LPTGS-KLSIVEVDRNP 236
Query: 243 DQSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLYELETGSNLFVNR 302
+ + K VD+FFP +AVNDFPI++++ Y + YV+TKYGFIH+Y+LET +++NR
Sbjct: 237 NNPA-FATKTVDLFFPPEAVNDFPIAIEIGSTYNVAYVVTKYGFIHVYDLETAKCIYMNR 295
Query: 303 ITADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNVSLALTMASRGGL 362
++ +S+F T + NG+ IN+KG VL+V I+ I+PY+L+ L++ LA+ MAS L
Sbjct: 296 VSGESIFVTTAHKSVNGLMAINRKGQVLSVSINPETIIPYILSNLNDPGLAVRMASHANL 355
Query: 363 PGADDLFEKQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQAPPGSISPILLY 420
PGAD+L+ +QF L++QG+YS AAKVAASS + LRT I++ K IQA PG I+PIL Y
Sbjct: 356 PGADNLYMQQFQQLMAQGNYSEAAKVAASSPRGILRTSQVIDQFKLIQAAPGQIAPILQY 415
Query: 421 FSTLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPFDTTLALA 480
F TLLDKG LN++E+IEL RP+L QNR QL EK+ E+KL C+E LGD+VKP++T AL
Sbjct: 416 FGTLLDKGPLNEHETIELARPVLAQNRIQLLEKWYGENKLACTEALGDLVKPYNTPFALK 475
Query: 481 TYLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLRTNPDKASEFAISLL 540
Y A V KV+ CL+EL F K+ Y+++ P++V L+ NL+R NPD+A+EFA +
Sbjct: 476 IYETANVPNKVVMCLSELGDFGKLATYTSQQNITPDYVSLLQNLVRVNPDQAAEFATQMF 535
Query: 541 -SNPETASQLEVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTRVLEINLLNAPQ 599
SNP + +EKI DIF SQN +QQ T+FLLDAL+ + P+ HLQTR+LEINL+NAPQ
Sbjct: 536 NSNPS----INLEKIVDIFMSQNLVQQATAFLLDALKDDNPEHSHLQTRLLEINLINAPQ 591
Query: 600 VADAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHTSSIPADWLVDF 659
VADAILGN +F+++D+ IA L E+AGL QRALE Y DIKR IVH++ + +WL+++
Sbjct: 592 VADAILGNQMFTHFDRAVIASLCERAGLVQRALELYDKPADIKRVIVHSNLLNPEWLMNY 651
Query: 660 FGKLNVEQSLACLKTLLDDNLEANLQIVIQVATKFSDLIGSQVLIKLFEDYRSNEGLYYY 719
F + + ++ L+ +L NL NLQIV+Q+AT++SDL+G+Q +I++FE +++ EGLYYY
Sbjct: 652 FSRFSPDEVYDYLREMLRSNLRQNLQIVVQIATRYSDLVGAQRIIEMFEKFKTFEGLYYY 711
Query: 720 LASLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFLKDAQLQDQMPL 779
L S+VN+T D EVV+KYIQAA F EVERI R+NNVY+PEKVKN LK+A+L DQ+PL
Sbjct: 712 LGSIVNITEDPEVVYKYIQAACLMNQFTEVERICRDNNVYNPEKVKNLLKEAKLADQLPL 771
Query: 780 VVVCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVDCDEKVITSLLD 839
++VCDR++ V+DLV YL+R F+FIE+YVQ++NPSKT QVV LLD+DCDE+++ +LL
Sbjct: 772 ILVCDRYDFVNDLVFYLFRNNMFQFIEIYVQRINPSKTPQVVGALLDIDCDEELVQNLLM 831
Query: 840 TVVGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIYIDSNNSPEKFL 899
+VVGQVP+DEL EVE+RNR QSG+Q++++Y+ LAKIYIDSNN+PE FL
Sbjct: 832 SVVGQVPVDELVEEVERRNRLKLLLPYLESLLQSGSQDRAIYDALAKIYIDSNNNPEVFL 891
Query: 900 KENDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLARSNSD 959
KEN+ YDTL VG+YCEKRDPYLA+IAYEKG ND ++I + NENSM+K ARYLL RS+S+
Sbjct: 892 KENNFYDTLTVGKYCEKRDPYLAFIAYEKGGNDTEIINLCNENSMFKQLARYLLKRSDSN 951
Query: 960 LWNIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTXXXXXXXXXXXX 1019
LW+ VL D+ +RR L+D VI+ +PE +DPE VS+ V+A M L +
Sbjct: 952 LWSEVLQ-DSAYRRPLLDQVIATAVPESSDPEAVSIVVKALMEVDLPSQLIELLEKIVLQ 1010
Query: 1020 PSPFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENELNEEAFEIYDK 1079
PS F++N LQ LL L+AI+ + ++V I+KLD YDVDEIA + IEN L EEAF IY
Sbjct: 1011 PSSFSENANLQNLLFLTAIKADKSRVMEYIDKLDKYDVDEIAEIAIENGLYEEAFRIYKI 1070
Query: 1080 HGKHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPEAIDSYIKAKDP 1139
H KH++A+KV+VED++ LDRA+ YA+ + PE+WS+L A+L+ +RIP+AI+SY+KA DP
Sbjct: 1071 HNKHEQAMKVLVEDIVSLDRAQDYAETVEQPEVWSRLAKAQLDGIRIPDAIESYLKADDP 1130
Query: 1140 SNFMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKLNEIENLLSVST 1199
SN+ VI+ A AGK+EEL+ YLLMAR + EP +D AL++AYA+ ++L E+E L S
Sbjct: 1131 SNYSEVIELASRAGKYEELIKYLLMARSKMHEPDVDSALLIAYAKTNQLTEMETFLIGSN 1190
Query: 1200 VANLEEVGDKLSQHNDYKAAKLCYSSISNYSKLASTLVYLGDYQNAVDTARKASNVKVWR 1259
VA+++ VGD+ + +Y+AAKL YSSISN+S LA+TLVYLG+YQ AVD ARKA+++KVW+
Sbjct: 1191 VADVKAVGDECFESKNYEAAKLMYSSISNWSMLATTLVYLGEYQGAVDCARKANSIKVWK 1250
Query: 1260 QVNDACISNKEFRLAQICGLNLVVHAEELDELVAVYEHNGYFEELISLFEAGLGLERAHM 1319
QV ACI +EFRLAQICGLNL+VHAEEL L+ +YE GYFEE+ISL EAGLGLERAHM
Sbjct: 1251 QVGTACIDKREFRLAQICGLNLIVHAEELPGLIRLYEERGYFEEVISLMEAGLGLERAHM 1310
Query: 1320 GMFTELAILYTKYNPSKTYEHLKLFWSRINIPKVIRAVEDAHLWPELIFLYAHYDEWDNA 1379
+TELAILY KY P + EHLKLFW R+N+ KVIRA + HLW E +FLY H +DNA
Sbjct: 1311 AFYTELAILYAKYKPERMMEHLKLFWGRLNMAKVIRACDQMHLWNEAVFLYVHDQSYDNA 1370
Query: 1380 ALTMIEKSAYNFDHSYFKEIIVKVSNLEIYYKAINFYVKEHPSLLVDLLTVLIPRLDIPR 1439
A M+E+ FDH FK+IIV V+NLE+YY+A+NFY+++HP LL DLL L PR+D PR
Sbjct: 1371 AAVMMEQPE-AFDHQSFKDIIVHVANLELYYRALNFYLEQHPMLLTDLLAALTPRIDHPR 1429
Query: 1440 TVRIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEVDYKALQDAVSSYDKFDQLE 1499
+RIF KS+N PLI F++ + N VN AY+DL+IE DY++LQD++ +YD FD +
Sbjct: 1430 VIRIFEKSENTPLILNFMVAIQHLNIQAVNHAYNDLLIEMEDYQSLQDSIENYDHFDAIA 1489
Query: 1500 LATRLENHEIIFFKIIAAELYRRNKKWAKSLAIFKGEQLWKHAIETAAISQSQQIAEDLL 1559
LA RLE H ++ F+ IAA +YR+NK+W +S+ + K ++ +K AI TA S IAEDL+
Sbjct: 1490 LARRLEKHSLLEFRRIAAYIYRKNKRWTQSIELSKQDRFYKDAIITARDSDQTTIAEDLM 1549
Query: 1560 SFFIETDNKEGFIALLYSCYHLITYDTVLEQAWLNNLETFIKPYEISVKKEQNDAIKQL- 1618
+F+E N E F A+LY+CYHL+ D V+E +W L+ + PY I+ + E + L
Sbjct: 1550 KYFVEIGNYECFAAILYTCYHLLRNDLVMEISWRKGLQDYAYPYFINFQCEMFSKVLNLE 1609
Query: 1619 ---------SSEFASKAKVGSNSDDQPLLLTNGAIGSQATGFSNY 1654
SE S + +G+ L+LT G + + F ++
Sbjct: 1610 KDLKDRQAVKSEEESASTIGAGILGNTLMLTQGPMANNNDQFDSF 1654
>Hs4758012 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1675
Score = 1566 bits (4056), Expect = 0.0
Identities = 786/1637 (48%), Positives = 1132/1637 (69%), Gaps = 10/1637 (0%)
Query: 4 LPIEFTELVDLTSLGISPQYLDFRSTTFESDHFVTVRESSNGTNTVAIVDLTNGNEVTRK 63
LPI F E + L +LGI+P + F + T ESD F+ +RE V I+D+ + + R+
Sbjct: 5 LPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRR 64
Query: 64 NMGGDSAIMHPSQKVISVRANGTIVQIFNLDTKSKLKSFQLDEPVIFWKWLSEDVLGFIT 123
+ DSAIM+P+ KVI+++A T+ QIFN++ KSK+K+ + + V FWKW+S + + +T
Sbjct: 65 PISADSAIMNPASKVIALKAGKTL-QIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVT 123
Query: 124 ANSLYVSNVFDGNVSAKPAKITDRHVNLNNTQIINFVANEKMDWFAVVGIIQENGKIAGK 183
N++Y ++ ++P K+ DRH +L QIIN+ + K W + GI + ++ G
Sbjct: 124 DNAVYHWSM---EGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA 180
Query: 184 IQLFSKTRGISQAIDGHVAIFSKILLDGNTEPVQVFVTGNRNVNTGAGELRIIEIDPPQD 243
+QL+S R +SQ I+GH A F++ ++GN E +F R G+L IIE+ P
Sbjct: 181 MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRG--QAGGKLHIIEVGTPPT 238
Query: 244 QSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLYELETGSNLFVNRI 303
+ + KK VD+FFP +A NDFP+++Q+SEK+ +++++TKYG+IHLY+LETG+ +++NRI
Sbjct: 239 GNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRI 298
Query: 304 TADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNVSLALTMASRGGLP 363
+ +++F + GI +N+KG VL+V ++ I+PY+ N L N LAL MA R L
Sbjct: 299 SGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLA 358
Query: 364 GADDLFEKQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQAPPGSISPILLYF 421
GA++LF ++F+ L +QG+YS AAKVAA++ + LRT TI + +++ A PG SP+L YF
Sbjct: 359 GAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYF 418
Query: 422 STLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPFDTTLALAT 481
LLD+G+LN+YES+EL RP+LQQ R QL EK+LKEDKL+CSEELGD+VK D TLAL+
Sbjct: 419 GILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSV 478
Query: 482 YLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLRTNPDKASEFAISLLS 541
YL+A V KVI C AE Q KI+ Y+ KVGY P+++ L+ N++R +PD+ +FA L+
Sbjct: 479 YLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQ 538
Query: 542 NPETASQLEVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTRVLEINLLNAPQVA 601
+ E + ++ +I D+F N IQQ T+FLLDAL++N P +G LQTR+LE+NL++APQVA
Sbjct: 539 DEEPLA--DITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVA 596
Query: 602 DAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHTSSIPADWLVDFFG 661
DAILGN +F++YD+ IA L EKAGL QRALE+++D+ DIKR +VHT + +WLV++FG
Sbjct: 597 DAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFG 656
Query: 662 KLNVEQSLACLKTLLDDNLEANLQIVIQVATKFSDLIGSQVLIKLFEDYRSNEGLYYYLA 721
L+VE SL CL+ +L N+ NLQI +QVA+K+ + + +Q LI+LFE ++S EGL+Y+L
Sbjct: 657 SLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLG 716
Query: 722 SLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFLKDAQLQDQMPLVV 781
S+VN + D +V FKYIQAA K G +EVERI RE+N YDPE+VKNFLK+A+L DQ+PL++
Sbjct: 717 SIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLII 776
Query: 782 VCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVDCDEKVITSLLDTV 841
VCDRF+ VHDLVLYLYR K+IE+YVQ+VNPS+ V+ GLLDVDC E VI +L+ V
Sbjct: 777 VCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVV 836
Query: 842 VGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIYIDSNNSPEKFLKE 901
GQ DEL AEVEKRNR G + + +N LAKIYIDSNN+PE+FL+E
Sbjct: 837 RGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRE 896
Query: 902 NDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLARSNSDLW 961
N YD+ VG+YCEKRDP+LA +AYE+GQ D +LI + NENS++K +RYL+ R + +LW
Sbjct: 897 NPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELW 956
Query: 962 NIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTXXXXXXXXXXXXPS 1021
VL N +RR L+D V+ + E DPE VS+TV+AFM+ L S
Sbjct: 957 GSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNS 1016
Query: 1022 PFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENELNEEAFEIYDKHG 1081
F+++ LQ LL+L+AI+ + +V I +LD+YD +IA + I NEL EEAF I+ K
Sbjct: 1017 VFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFD 1076
Query: 1082 KHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPEAIDSYIKAKDPSN 1141
+ A++V++E + LDRA +A++ N P +WSQL A+L + EAIDSYIKA DPS+
Sbjct: 1077 VNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSS 1136
Query: 1142 FMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKLNEIENLLSVSTVA 1201
+M V++AA +G +EELV YL MAR+ +E ++ LI A A+ ++L E+E ++ A
Sbjct: 1137 YMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNA 1196
Query: 1202 NLEEVGDKLSQHNDYKAAKLCYSSISNYSKLASTLVYLGDYQNAVDTARKASNVKVWRQV 1261
++++VGD+ Y AAKL Y+++SN+ +LASTLV+LG+YQ AVD ARKA++ + W++V
Sbjct: 1197 HIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEV 1256
Query: 1262 NDACISNKEFRLAQICGLNLVVHAEELDELVAVYEHNGYFEELISLFEAGLGLERAHMGM 1321
AC+ KEFRLAQ+CGL++VVHA+EL+EL+ Y+ GYFEELI++ EA LGLERAHMGM
Sbjct: 1257 CFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGM 1316
Query: 1322 FTELAILYTKYNPSKTYEHLKLFWSRINIPKVIRAVEDAHLWPELIFLYAHYDEWDNAAL 1381
FTELAILY+K+ P K EHL+LFWSR+NIPKV+RA E AHLW EL+FLY Y+E+DNA +
Sbjct: 1317 FTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAII 1376
Query: 1382 TMIEKSAYNFDHSYFKEIIVKVSNLEIYYKAINFYVKEHPSLLVDLLTVLIPRLDIPRTV 1441
TM+ + FK+II KV+N+E+YY+AI FY++ P LL DLL VL PRLD R V
Sbjct: 1377 TMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAV 1436
Query: 1442 RIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEVDYKALQDAVSSYDKFDQLELA 1501
FSK LPL+KP+L +V NN VN++ ++L I E DY+AL+ ++ +YD FD + LA
Sbjct: 1437 NYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLA 1496
Query: 1502 TRLENHEIIFFKIIAAELYRRNKKWAKSLAIFKGEQLWKHAIETAAISQSQQIAEDLLSF 1561
RLE HE+I F+ IAA L++ N +W +S+ + K + L+K A++ A+ S+ ++AE+LL +
Sbjct: 1497 QRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQW 1556
Query: 1562 FIETDNKEGFIALLYSCYHLITYDTVLEQAWLNNLETFIKPYEISVKKEQNDAIKQLSSE 1621
F++ + +E F A L++CY L+ D VLE AW +N+ F PY I V KE + +L +
Sbjct: 1557 FLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDAS 1616
Query: 1622 FASKAKVGSNSDDQPLL 1638
+ + + ++ QP++
Sbjct: 1617 ESLRKEEEQATETQPIV 1633
>7293138 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1678
Score = 1552 bits (4019), Expect = 0.0
Identities = 784/1638 (47%), Positives = 1124/1638 (67%), Gaps = 11/1638 (0%)
Query: 4 LPIEFTELVDLTSLGISPQYLDFRSTTFESDHFVTVRESSNGTNTVAIVDLTNGNEVTRK 63
LPI F E + LT++GI+ F + T ESD F+ VRE N T V I+D+ + TR+
Sbjct: 5 LPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRR 64
Query: 64 NMGGDSAIMHPSQKVISVRANGTIVQIFNLDTKSKLKSFQLDEPVIFWKWLSEDVLGFIT 123
+ DSAIM+P+ KVI+++A T+ QIFN++ KSK+K+ ++E V+FWKW+S + L +T
Sbjct: 65 PISADSAIMNPASKVIALKAQKTL-QIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVT 123
Query: 124 ANSLYVSNVFDGNVSAKPAKITDRHVNLNNTQIINFVANEKMDWFAVVGIIQENGKIAGK 183
S++ ++ +G+ + P K+ DRH +LN QIIN+ N W +VGI ++AG
Sbjct: 124 ETSVFHWSM-EGD--SMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGA 180
Query: 184 IQLFSKTRGISQAIDGHVAIFSKILLDGNTEPVQVFVTGNRNVNTGAGELRIIEIDPPQD 243
+QL+S R +SQAI+GH A F+ +D N EP +F R G+L IIE+ P +
Sbjct: 181 MQLYSVERKVSQAIEGHAASFATFKIDANKEPTTLFCFAVRTAT--GGKLHIIEVGAPPN 238
Query: 244 QSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLYELETGSNLFVNRI 303
+ + KK VD+FFP +A NDFP+++QVS KY IY++TKYG+IHLY++ET + +++NRI
Sbjct: 239 GNQPFAKKAVDVFFPPEAQNDFPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRI 298
Query: 304 TADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNVSLALTMASRGGLP 363
+AD++F + GI +N+KG VL+V +D QI+PY+ L N LAL MA R L
Sbjct: 299 SADTIFVTAPHEASGGIIGVNRKGQVLSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLA 358
Query: 364 GADDLFEKQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQAPPGSISPILL-Y 420
GA+DLF ++F+ L + G Y+ AAKVAA + + LRT TI + + +Q P GS +P LL Y
Sbjct: 359 GAEDLFVRKFNKLFTAGQYAEAAKVAALAPKAILRTPQTIQRFQQVQTPAGSTTPPLLQY 418
Query: 421 FSTLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPFDTTLALA 480
F LLD+GKLN++ES+EL RP+L Q + QL EK+LKE+KL+CSEELGD+VK D TLAL+
Sbjct: 419 FGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLKEEKLECSEELGDLVKASDLTLALS 478
Query: 481 TYLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLRTNPDKASEFAISLL 540
YL+A V KVI C AE QF KI+ Y+ KV Y P++V L+ +++R+NP++ + FA L+
Sbjct: 479 IYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLLRSVMRSNPEQGAGFASMLV 538
Query: 541 SNPETASQLEVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTRVLEINLLNAPQV 600
+ E + ++ +I DIF + +QQ T+FLLDAL+ N P +G LQTR+LE+NL++APQV
Sbjct: 539 AEEEPLA--DINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTRLLEMNLMSAPQV 596
Query: 601 ADAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHTSSIPADWLVDFF 660
ADAILGN +F++YD+ IA L EKAGL QRALE+Y+D+ DIKR +VHT + A+WLV FF
Sbjct: 597 ADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNAEWLVSFF 656
Query: 661 GKLNVEQSLACLKTLLDDNLEANLQIVIQVATKFSDLIGSQVLIKLFEDYRSNEGLYYYL 720
G L+VE SL CLK +L NL NLQI +Q+ATK+ + + ++ LI LFE ++S +GL+Y+L
Sbjct: 657 GTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFYFL 716
Query: 721 ASLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFLKDAQLQDQMPLV 780
+S+VN + D EV FKYIQAA K +EVERI RE+N Y+PE+VKNFLK+A+L DQ+PL+
Sbjct: 717 SSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLI 776
Query: 781 VVCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVDCDEKVITSLLDT 840
+VCDRF+ VHDLVLYLYR K+IE+YVQ+VNPS+ VV GLLDVDC E +I +L+
Sbjct: 777 IVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILV 836
Query: 841 VVGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIYIDSNNSPEKFLK 900
V GQ DEL EVEKRNR G + +N LAKIYIDSNN+PE++LK
Sbjct: 837 VKGQFSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLK 896
Query: 901 ENDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLARSNSDL 960
EN YD+ VGRYCEKRDP+LA +AYE+G D +LI + NENS++K +ARYL+ R +++L
Sbjct: 897 ENQYYDSRVVGRYCEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAEL 956
Query: 961 WNIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTXXXXXXXXXXXXP 1020
W VLS N ++RQL+D V+ + E DP+ +S+TV+AFM+ L
Sbjct: 957 WAEVLSESNPYKRQLIDQVVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDS 1016
Query: 1021 SPFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENELNEEAFEIYDKH 1080
S F+D+ LQ LL+L+AI+ + +V I +L++YD +IA + I N+L EEAF I+ K
Sbjct: 1017 SVFSDHRNLQNLLILTAIKADRTRVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKF 1076
Query: 1081 GKHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPEAIDSYIKAKDPS 1140
+ A++V+++ + L+RA +A++ N P +WSQL A+L + EAIDSYIKA DPS
Sbjct: 1077 DVNTSAIQVLIDQVNNLERANEFAERCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADDPS 1136
Query: 1141 NFMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKLNEIENLLSVSTV 1200
+++V+ A +++LV YL MAR+ +E I+ LI AYA +L ++E +S
Sbjct: 1137 AYVDVVDVASKVESWDDLVRYLQMARKKARESYIESELIYAYARTGRLADLEEFISGPNH 1196
Query: 1201 ANLEEVGDKLSQHNDYKAAKLCYSSISNYSKLASTLVYLGDYQNAVDTARKASNVKVWRQ 1260
A+++++G++ Y AAKL Y+++SN+++LA TLVYL ++Q AVD+ARKA++ + W++
Sbjct: 1197 ADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVYLKEFQGAVDSARKANSTRTWKE 1256
Query: 1261 VNDACISNKEFRLAQICGLNLVVHAEELDELVAVYEHNGYFEELISLFEAGLGLERAHMG 1320
V AC+ +EFRLAQ+CGL++VVHA+EL++L+ Y++ GYF+ELI+L E+ LGLERAHMG
Sbjct: 1257 VCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDELIALLESALGLERAHMG 1316
Query: 1321 MFTELAILYTKYNPSKTYEHLKLFWSRINIPKVIRAVEDAHLWPELIFLYAHYDEWDNAA 1380
MFTELAILY+K+ PSK EHL+LFWSR+NIPKV+RA E AHLW EL+FLY Y+E+DNA
Sbjct: 1317 MFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELVFLYDKYEEYDNAV 1376
Query: 1381 LTMIEKSAYNFDHSYFKEIIVKVSNLEIYYKAINFYVKEHPSLLVDLLTVLIPRLDIPRT 1440
L M+ + +FK+II KV+N+E+YYKAI FY+ P LL D+L VL PR+D R
Sbjct: 1377 LAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLVLAPRMDHTRA 1436
Query: 1441 VRIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEVDYKALQDAVSSYDKFDQLEL 1500
V FSK+ LPL+KP+L +V NN +N+A + L+I+E DY+ L++++ +D FD + L
Sbjct: 1437 VSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNIAL 1496
Query: 1501 ATRLENHEIIFFKIIAAELYRRNKKWAKSLAIFKGEQLWKHAIETAAISQSQQIAEDLLS 1560
A +LE HE+ F+ IAA LY+ N +W +S+ + K ++L+K A+E AA S Q IAE+LL
Sbjct: 1497 AQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLG 1556
Query: 1561 FFIETDNKEGFIALLYSCYHLITYDTVLEQAWLNNLETFIKPYEISVKKEQNDAIKQLSS 1620
+F+E D + F A LY CY L+ D +LE AW + + F PY I V +E + +L
Sbjct: 1557 WFLERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLEL 1616
Query: 1621 EFASKAKVGSNSDDQPLL 1638
A + K +++ + ++
Sbjct: 1617 NEAQREKEDDSTEHKNII 1634
>Hs9257202 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1626
Score = 1507 bits (3902), Expect = 0.0
Identities = 760/1619 (46%), Positives = 1111/1619 (67%), Gaps = 10/1619 (0%)
Query: 4 LPIEFTELVDLTSLGISPQYLDFRSTTFESDHFVTVRESSNGTNTVAIVDLTNGNEVTRK 63
LP+ F E L +LGI+P + F + T ESD F+ +RE V I+D+++ R+
Sbjct: 5 LPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDMSDPMAPIRR 64
Query: 64 NMGGDSAIMHPSQKVISVRANGTIVQIFNLDTKSKLKSFQLDEPVIFWKWLSEDVLGFIT 123
+ +SAIM+P+ KVI+++A T+ QIFN++ KSK+K+ + E VIFWKW+S + + +T
Sbjct: 65 PISAESAIMNPASKVIALKAGKTL-QIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVT 123
Query: 124 ANSLYVSNVFDGNVSAKPAKITDRHVNLNNTQIINFVANEKMDWFAVVGIIQENGKIAGK 183
++Y ++ +G+ ++P K+ DRH +L Q+I++ +E W +VGI + ++ G
Sbjct: 124 ETAVYHWSM-EGD--SQPMKMFDRHTSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGA 180
Query: 184 IQLFSKTRGISQAIDGHVAIFSKILLDGNTEPVQVFVTGNRNVNTGAGELRIIEIDPPQD 243
+QL+S R +SQ I+GH A F++ ++GN +P +F RN G+L IIE+ P
Sbjct: 181 MQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPT--GGKLHIIEVGQPAA 238
Query: 244 QSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLYELETGSNLFVNRI 303
+ + KK VD+FFP +A NDFP+++Q+ K+G+IY++TKYG++HLY+LE+G + +NRI
Sbjct: 239 GNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRI 298
Query: 304 TADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNVSLALTMASRGGLP 363
+AD++F + +GI +NKKG VL+V ++ IV Y N L N L L +A R L
Sbjct: 299 SADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLA 358
Query: 364 GADDLFEKQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQAPPGSISPILLYF 421
GA+ LF ++F+ L +QG Y+ AAKVAAS+ + LRT+ T+ K ++I A G SP+L YF
Sbjct: 359 GAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYF 418
Query: 422 STLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPFDTTLALAT 481
LLD+G+LN+ ES+EL +LQQ R QL EK+LKEDKL+CSEELGD+VK D LAL+
Sbjct: 419 GILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSV 478
Query: 482 YLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLRTNPDKASEFAISLLS 541
YL+A V KVI C AE QF KI+ Y+ KVGY P+++ L+ +++ +P++ +F+ L+
Sbjct: 479 YLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQ 538
Query: 542 NPETASQLEVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTRVLEINLLNAPQVA 601
+ E + + +I DIF + IQQ TSFLLDAL++N P +G LQT +LE+NL++APQVA
Sbjct: 539 DEEPLAN--ISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVA 596
Query: 602 DAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHTSSIPADWLVDFFG 661
DAILGN +F++YD+ IA L EKAGL Q+ALE+Y+D+ DIKR +VHT + +WLV+FFG
Sbjct: 597 DAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFG 656
Query: 662 KLNVEQSLACLKTLLDDNLEANLQIVIQVATKFSDLIGSQVLIKLFEDYRSNEGLYYYLA 721
L+VE S+ CL +L N+ NLQ+ +QVA+K+ +G+Q L++LFE ++S +GL+Y+L
Sbjct: 657 SLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHKQLGTQALVELFESFKSYKGLFYFLG 716
Query: 722 SLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFLKDAQLQDQMPLVV 781
S+VN + D +V KYIQAA K G +EVERI RE++ Y+PE+VKNFLK+A+L DQ+PL++
Sbjct: 717 SIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLII 776
Query: 782 VCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVDCDEKVITSLLDTV 841
VCDRF VHDLVLYLYR ++IE+YVQ+VNPS+T V+ GLLDVDC E+VI L+ V
Sbjct: 777 VCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAV 836
Query: 842 VGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIYIDSNNSPEKFLKE 901
GQ DEL AEVEKRNR Q G + + +N LAKIYIDSNNSPE FL+E
Sbjct: 837 RGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRE 896
Query: 902 NDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLARSNSDLW 961
N YD+ VGRYCEKRDP+LA +AYE+GQ D +LI++ NENS++K +ARYL+ R + +LW
Sbjct: 897 NAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELW 956
Query: 962 NIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTXXXXXXXXXXXXPS 1021
VL N RRQL+D V+ + E DPE +S+TV+AFM+ L S
Sbjct: 957 AHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNS 1016
Query: 1022 PFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENELNEEAFEIYDKHG 1081
F+++ LQ LL+L+AI+ + +V I +LD+YD +IA + + + L EEAF ++ K
Sbjct: 1017 VFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFD 1076
Query: 1082 KHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPEAIDSYIKAKDPSN 1141
+ A++V++E + LDRA +A++ N P +WSQL A+L + EAI+SYI+ DPS+
Sbjct: 1077 MNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSS 1136
Query: 1142 FMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKLNEIENLLSVSTVA 1201
++ V+++A + +E+LV +L MAR+ +E I+ LI A A+ S+++E+E+ ++ A
Sbjct: 1137 YLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNA 1196
Query: 1202 NLEEVGDKLSQHNDYKAAKLCYSSISNYSKLASTLVYLGDYQNAVDTARKASNVKVWRQV 1261
++++VGD+ + Y+AAKL YS++SN+++LASTLV+LG+YQ AVD +RKAS+ + W++V
Sbjct: 1197 HIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEV 1256
Query: 1262 NDACISNKEFRLAQICGLNLVVHAEELDELVAVYEHNGYFEELISLFEAGLGLERAHMGM 1321
AC+ +EFR AQ+CGL++V+HA+EL+EL+ Y+ GYFEELI L EA LGLERAHMGM
Sbjct: 1257 CFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGM 1316
Query: 1322 FTELAILYTKYNPSKTYEHLKLFWSRINIPKVIRAVEDAHLWPELIFLYAHYDEWDNAAL 1381
FTELAILY+K+ P K EHL+LFWSR+NIPKV+RA E AHLW EL+FLY Y+E+DNA L
Sbjct: 1317 FTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVL 1376
Query: 1382 TMIEKSAYNFDHSYFKEIIVKVSNLEIYYKAINFYVKEHPSLLVDLLTVLIPRLDIPRTV 1441
TM+ + FK+II KV+N+E+ Y+A+ FY+ P L+ DLL VL PRLD TV
Sbjct: 1377 TMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTV 1436
Query: 1442 RIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEVDYKALQDAVSSYDKFDQLELA 1501
FSK+ LPL+KP+L +V NN VN+A + L+ E+ DY+ L+ ++ +YD FD + LA
Sbjct: 1437 SFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEKEDYQGLRASIDAYDNFDNISLA 1496
Query: 1502 TRLENHEIIFFKIIAAELYRRNKKWAKSLAIFKGEQLWKHAIETAAISQSQQIAEDLLSF 1561
+LE H+++ F+ IAA LY+ N WA+S+ + K + L+K A++ AA S+ ++A+ LL +
Sbjct: 1497 QQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQW 1556
Query: 1562 FIETDNKEGFIALLYSCYHLITYDTVLEQAWLNNLETFIKPYEISVKKEQNDAIKQLSS 1620
F+E +E F A L++CY L+ D VLE AW +NL PY I V +E + +L +
Sbjct: 1557 FLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDA 1615
>CE00480 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1681
Score = 1489 bits (3855), Expect = 0.0
Identities = 754/1657 (45%), Positives = 1105/1657 (66%), Gaps = 17/1657 (1%)
Query: 4 LPIEFTELVDLTSLGISPQYLDFRSTTFESDHFVTVRESSNGTNTVAIVDLTNGNEVTRK 63
LPI+F E + L + GI + F + T ESD + VRE V I+DL + TR+
Sbjct: 3 LPIKFHEHLQLPNAGIRVPNITFSNVTMESDKNIVVREMIGDQQQVVIIDLADTANPTRR 62
Query: 64 NMGGDSAIMHPSQKVISVRANGTIVQIFNLDTKSKLKSFQLDEPVIFWKWLSEDVLGFIT 123
+ DS IMHP+ K++++++ T+ QIFN++ K+K+K+ Q E V++WKW+SE + ++
Sbjct: 63 PISADSVIMHPTAKILALKSGKTL-QIFNIELKAKVKAHQNVEDVVYWKWISEKTIALVS 121
Query: 124 ANSLYVSNVFDGNVSAKPAKITDRHVNLNNTQIINFVANEKMDWFAVVGIIQENGKIAGK 183
++Y ++ +G+ A P K+ DRH +L TQIIN+ A+ + W ++GI ++ ++ G
Sbjct: 122 DTAVYHWSI-EGD--AAPVKMFDRHQSLAGTQIINYRADAENKWLVLIGISAKDSRVVGS 178
Query: 184 IQLFSKTRGISQAIDGHVAIFSKILLDGNTEPVQVFVTGNRNVNTGAGELRIIEIDPPQD 243
+QL+S R +SQ I+GH A F + +DGN P +F + N G+L +IE+ P
Sbjct: 179 MQLYSTERKVSQPIEGHAACFVRFKVDGNQNPSNLFCFSVKTDN--GGKLHVIEVGTPAA 236
Query: 244 QSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLYELETGSNLFVNRI 303
+ +QKK VD+ + AD DFP+S+QVS K GIIY++TK G++HLY++E+G+ ++ NRI
Sbjct: 237 GNTPFQKKNVDVPYTADTAGDFPVSMQVSAKQGIIYLVTKQGYVHLYDVESGTRIYSNRI 296
Query: 304 TADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNVSLALTMASRGGLP 363
+ D+VF Y GI IN+KG VL+V ID +VP+V N+L N LAL +A R LP
Sbjct: 297 STDTVFVTCEYTATGGIMGINRKGQVLSVSIDEANLVPFVTNQLQNPDLALKLAVRCDLP 356
Query: 364 GADDLFEKQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQAPPGSISPILLYF 421
GA++LF ++F+ L S G + +AKVAAS+ Q LRT ATI K + + SP+L YF
Sbjct: 357 GAEELFVRKFNLLFSNGQFGESAKVAASAPQGILRTPATIQKFQQCPSTGPGPSPLLQYF 416
Query: 422 STLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPFDTTLALAT 481
LLD+GKLN+YE++EL RP+L Q R +L K+L + KL+C EELGD++KP D AL+
Sbjct: 417 GILLDQGKLNKYETLELCRPVLAQGRKELITKWLNDQKLECCEELGDLIKPHDVNTALSV 476
Query: 482 YLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLR-TNPDKASEFAISLL 540
YL+ V KV+ AE QFDKI+ Y+ +VG+ P+++ + +LR +NPD ++FA L+
Sbjct: 477 YLRGNVPHKVVQSFAETGQFDKIVMYAKRVGFQPDYLFQLRQILRNSNPDHGAKFAQLLV 536
Query: 541 SNPETASQL-EVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTRVLEINLLNAPQ 599
S E L ++ +I D F +Q TSFLL+ L+ + P++GHLQTR+LE+NLL AP
Sbjct: 537 SESENGEPLADLSQIIDCFMEVQAVQPCTSFLLEVLKGDKPEEGHLQTRLLEMNLLAAPA 596
Query: 600 VADAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHTSSIPADWLVDF 659
VADAIL N +FS+YD+ I L EKAGL QRALE+++D+ DIKR +VHT + DWLV +
Sbjct: 597 VADAILANKMFSHYDRAAIGQLCEKAGLLQRALEHFTDLYDIKRTVVHTHLLKPDWLVGY 656
Query: 660 FGKLNVEQSLACLKTLLDDNLEANLQIVIQVATKFSDLIGSQVLIKLFEDYRSNEGLYYY 719
FG L+VE S+ CLK +L N+ NLQ+V+Q+A+K+ + +G+ LI++FE+++S EGL+Y+
Sbjct: 657 FGSLSVEDSVECLKAMLTQNIRQNLQVVVQIASKYHEQLGADKLIEMFENHKSYEGLFYF 716
Query: 720 LASLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFLKDAQLQDQMPL 779
L S+VN + D EV FKYIQAA + G +EVERI RE+ YD E+VKNFLK+A+L DQ+PL
Sbjct: 717 LGSIVNFSQDPEVHFKYIQAATRTGQIKEVERICRESQCYDAERVKNFLKEAKLNDQLPL 776
Query: 780 VVVCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVDCDEKVITSLLD 839
++VCDR NMVHDLVLYLYR + K+IEV+VQ+VN ++ VV LLDVDC E I L+
Sbjct: 777 IIVCDRHNMVHDLVLYLYRNQLQKYIEVFVQKVNAARLPIVVGALLDVDCSEDAIKQLII 836
Query: 840 TVVGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIYIDSNNSPEKFL 899
G+ IDEL EVEKRNR Q G + + +N +AKIYIDSNN+PE+FL
Sbjct: 837 NTRGKFDIDELVEEVEKRNRLKLLNHWLESKIQEGATDAATHNAMAKIYIDSNNNPERFL 896
Query: 900 KENDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLARSNSD 959
KEN YD+ VG+YCEKRDP+ A+++YE+GQ D +LI + NENS++K ARYL+ R +
Sbjct: 897 KENPYYDSKVVGKYCEKRDPHYAFLSYERGQCDAELINVCNENSLFKNLARYLVKRRDFT 956
Query: 960 LWNIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTXXXXXXXXXXXX 1019
LW VL+ +N+HRRQL+D V+ + E DPE +S+TV+AFM+ L
Sbjct: 957 LWEQVLNEENVHRRQLIDQVVQTALSETQDPEDISVTVKAFMAADLPNELIELLEKIVLD 1016
Query: 1020 PSPFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENELNEEAFEIYDK 1079
S F+++ LQ LL+L+A+R + +V I+KLD+YD +IA + I +EL EEAF I+ K
Sbjct: 1017 NSAFSEHRNLQNLLILTAMRADRTRVMEYIQKLDNYDAPDIANIAITSELYEEAFAIFKK 1076
Query: 1080 HGKHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPEAIDSYIKAKDP 1139
+ A+ V++E++ LDRA +A+K N ++W+ L A+L + EA+DS+IKA DP
Sbjct: 1077 FDVNSSAINVLIENVNNLDRAYEFAEKCNQSDVWASLAKAQLQQNLVKEAVDSFIKADDP 1136
Query: 1140 SNFMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKLNEIENLLSVST 1199
+M V+ +E+LV YL MAR+ +E I+ L+ A A+ +L E+E ++
Sbjct: 1137 GAYMEVVNKCSQTEHWEDLVRYLQMARKKSRESYIETELVFALAKTGRLTELEEFIAGPN 1196
Query: 1200 VANLEEVGDKLSQHNDYKAAKLCYSSISNYSKLASTLVYLGDYQNAVDTARKASNVKVWR 1259
A + ++GD+ + + +AK+ ++++SN++KL+ TLV LG+YQ AVD ARKA++ K W+
Sbjct: 1197 HAQIGQIGDRCFDNGMFDSAKILFNNVSNFAKLSVTLVRLGEYQGAVDAARKANSTKTWK 1256
Query: 1260 QVNDACISNKEFRLAQICGLNLVVHAEELDELVAVYEHNGYFEELISLFEAGLGLERAHM 1319
QV +C+ N EFRLAQ+CGL++VVHA+EL+EL+ Y+ G+FEELI+L EA LGLERAHM
Sbjct: 1257 QVCFSCVENGEFRLAQMCGLHIVVHADELEELINFYQDRGHFEELIALLEAALGLERAHM 1316
Query: 1320 GMFTELAILYTKYNPSKTYEHLKLFWSRINIPKVIRAVEDAHLWPELIFLYAHYDEWDNA 1379
GMFTELAILY+KY P K EHL+LFWSR+NIPKV+RA E AHLW EL+FLY Y+E+DNA
Sbjct: 1317 GMFTELAILYSKYKPEKMREHLELFWSRVNIPKVLRAAEQAHLWSELVFLYDKYEEYDNA 1376
Query: 1380 ALTMIEKSAYNFDHSYFKEIIVKVSNLEIYYKAINFYVKEHPSLLVDLLTVLIPRLDIPR 1439
ALTM++ ++ +FKE+I KV+N+E+YYKA+ FY+ P LL DLLTVL PRLD R
Sbjct: 1377 ALTMMQHPTESWREQHFKEVIAKVANVELYYKAMQFYLDYKPLLLNDLLTVLSPRLDHSR 1436
Query: 1440 TVRIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEVDYKALQDAVSSYDKFDQLE 1499
TV F+K +PL+KP+L V NN +N+A + L+I+E D+ L+ ++ + D FD +
Sbjct: 1437 TVLFFNKLKQIPLVKPYLRQVQNLNNKAINEALNQLLIDEEDHAGLRSSIEAQDNFDNIT 1496
Query: 1500 LATRLENHEIIFFKIIAAELYRRNKKWAKSLAIFKGEQLWKHAIETAAISQSQQIAEDLL 1559
LA +LE H ++ F+ I+A L++ N +W +S+ + K ++L+K A+E AA S++ ++AE+LL
Sbjct: 1497 LAQQLEKHPLVEFRRISAYLFKGNNRWKQSIELCKKDKLYKDAMEYAAESRNGELAEELL 1556
Query: 1560 SFFIETDNKEGFIALLYSCYHLITYDTVLEQAWLNNLETFIKPYEISVKKEQNDAIKQL- 1618
SFF++ + F A LY CY L+ D ++E AW + + + PY I V ++ +++L
Sbjct: 1557 SFFLDEKLYDCFAASLYHCYDLLHPDVIMELAWKHKIMDYAMPYMIQVMRDYQTRLEKLE 1616
Query: 1619 ------SSEFASKAKVGSNSDDQPLLLTNGAIGSQAT 1649
E A + + + + L+LT GA Q T
Sbjct: 1617 RSEHERKEEKAEQQQNNGMTMEPQLMLTYGAPAPQMT 1653
>Hs4502903 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1569
Score = 1427 bits (3693), Expect = 0.0
Identities = 739/1620 (45%), Positives = 1071/1620 (65%), Gaps = 69/1620 (4%)
Query: 4 LPIEFTELVDLTSLGISPQYLDFRSTTFESDHFVTVRESSNGTNTVAIVDLTNGNEVTRK 63
LP+ F E L +LGI+P + F + T ESD F+ +RE V I+D+++ R+
Sbjct: 5 LPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDMSDPMAPIRR 64
Query: 64 NMGGDSAIMHPSQKVISVRANGTIVQIFNLDTKSKLKSFQLDEPVIFWKWLSEDVLGFIT 123
+ +SAIM+P+ KVI+++A T+ QIFN++ KSK+K+ + E VIFWKW+S + + +T
Sbjct: 65 PISAESAIMNPASKVIALKAGKTL-QIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVT 123
Query: 124 ANSLYVSNVFDGNVSAKPAKITDRHVNLNNTQIINFVANEKMDWFAVVGIIQENGKIAGK 183
++Y ++ +G+ ++P K+ DRH +L Q+I++ +E W +VGI + ++ G
Sbjct: 124 ETAVYHWSM-EGD--SQPMKMFDRHTSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGA 180
Query: 184 IQLFSKTRGISQAIDGHVAIFSKILLDGNTEPVQVFVTGNRNVNTGAGELRIIEIDPPQD 243
+QL+S R +SQ I+GH A F++ ++GN +P +F RN G+L IIE+ P
Sbjct: 181 MQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPT--GGKLHIIEVGQPAA 238
Query: 244 QSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLYELETGSNLFVNRI 303
+ + KK VD+FFP +A NDFP+++Q+ K+G+IY++TKYG++HLY+LE+G + +NRI
Sbjct: 239 GNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRI 298
Query: 304 TADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNVSLALTMASRGGLP 363
+AD++F + +GI +NKKG VL+V ++ IV Y N L N L L +A R L
Sbjct: 299 SADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLA 358
Query: 364 GADDLFEKQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQAPPGSISPILLYF 421
GA+ LF ++F+ L +QG Y+ AAKVAAS+ + LRT+ T+ K ++I A G SP+L YF
Sbjct: 359 GAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYF 418
Query: 422 STLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPFDTTLALAT 481
LLD+G+LN+ ES+EL +LQQ R QL EK+LKEDKL+CSEELGD+VK D LAL+
Sbjct: 419 GILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSV 478
Query: 482 YLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLRTNPDKASEFAISLLS 541
YL+A V KVI C AE QF KI+ Y+ KVGY P+++ L+ +++ +P++ +F+ L+
Sbjct: 479 YLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQ 538
Query: 542 NPETASQLEVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTRVLEINLLNAPQVA 601
+ E + + +I DIF + IQQ TSFLLDAL++N P +G LQT +LE+NL++APQVA
Sbjct: 539 DEEPLAN--ISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVA 596
Query: 602 DAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHTSSIPADWLVDFFG 661
DAILGN +F++YD+ IA L EKAGL Q+ALE+Y+D+ DIKR +VHT + +WLV+FFG
Sbjct: 597 DAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFG 656
Query: 662 KLNVEQSLACLKTLLDDNLEANLQIVIQVATKFSDLIGSQVLIKLFEDYRSNEGLYYYLA 721
L+VE S+ CL +L N+ NLQ+ +QVA+K+ +G+Q L++LFE ++S +GL+Y+L
Sbjct: 657 SLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHKQLGTQALVELFESFKSYKGLFYFLG 716
Query: 722 SLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFLKDAQLQDQMPLVV 781
S+VN + D +V KYIQAA K G +EVERI RE++ Y+PE+VKNFLK+A+L DQ+PL++
Sbjct: 717 SIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLII 776
Query: 782 VCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVDCDEKVITSLLDTV 841
VCDRF VHDLVLYLYR ++IE+YVQ+VNPS+T V+ GLLDVDC E+VI L+ V
Sbjct: 777 VCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAV 836
Query: 842 VGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIYIDSNNSPEKFLKE 901
GQ DEL AEVEKRNR Q G + + +N LAKIYIDSNNSPE FL+E
Sbjct: 837 RGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRE 896
Query: 902 NDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLARSNSDLW 961
N YD+ VGRYCEKRDP+LA +AYE+GQ D +LI++ NENS++K +ARYL+ R + +LW
Sbjct: 897 NAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELW 956
Query: 962 NIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTXXXXXXXXXXXXPS 1021
VL N RRQL+D V+ + E DPE +S+TV+AFM+ L S
Sbjct: 957 AHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNS 1016
Query: 1022 PFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENELNEEAFEIYDKHG 1081
F+++ LQ LL+L+AI+ + +V I +LD+YD +IA + + + L EEAF ++ K
Sbjct: 1017 VFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFD 1076
Query: 1082 KHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPEAIDSYIKAKDPSN 1141
+ A++V++E + LDRA +A++ N P +WSQL A+L + EAI+SYI+ DPS+
Sbjct: 1077 MNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSS 1136
Query: 1142 FMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKLNEIENLLSVSTVA 1201
++ V+++A + +E+LV +L MAR+ +E I+ LI A A+ S+++E+E+ ++ A
Sbjct: 1137 YLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNA 1196
Query: 1202 NLEEVGDKLSQHNDYKAAKLCYSSISNYSKLASTLVYLGDYQNAVDTARKASNVKVWRQV 1261
++++VGD+ + Y+AAKL YS++SN+++LASTLV+LG+YQ AVD +RKAS+ + W++V
Sbjct: 1197 HIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEV 1256
Query: 1262 NDACISNKEFRLAQICGLNLVVHAEELDELVAVYEHNGYFEELISLFEAGLGLERAHMGM 1321
AC+ +EFR AQ+CGL++V+HA+EL+EL+ Y+ GYFEELI L EA LGLERAHMGM
Sbjct: 1257 CFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGM 1316
Query: 1322 FTELAILYTKYNPSKTYEHLKLFWSRINIPKVIRAVEDAHLWPELIFLYAHYDEWDNAAL 1381
FTELAILY+K+ P K EHL+LFWSR+NIPKV+RA E AHLW EL+FLY Y+E+DNA L
Sbjct: 1317 FTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVL 1376
Query: 1382 TMIEKSAYNFDHSYFKEIIVKVSNLEIYYKAINFYVKEHPSLLVDLLTVLIPRLDIPRTV 1441
TM+ + FK+II KV+N+E+ Y+A+ FY+ P L+ DLL VL PRLD TV
Sbjct: 1377 TMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTV 1436
Query: 1442 RIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEVDYK-ALQDAVSSYDKFDQLEL 1500
FSK+ LPL+KP+L +V NN VN+A + L+ E+ DY+ A+Q A S D
Sbjct: 1437 SFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEKEDYQDAMQHAAESRD------- 1489
Query: 1501 ATRLENHEIIFFKIIAAELYRRNKKWAKSLAIFKGEQLWKHAIETAAISQSQQIAEDLLS 1560
AEL ++ +W
Sbjct: 1490 ----------------AELAQKLLQW---------------------------------- 1499
Query: 1561 FFIETDNKEGFIALLYSCYHLITYDTVLEQAWLNNLETFIKPYEISVKKEQNDAIKQLSS 1620
F+E +E F A L++CY L+ D VLE AW +NL PY I V +E + +L +
Sbjct: 1500 -FLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDA 1558
>At3g11130 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1705
Score = 1385 bits (3586), Expect = 0.0
Identities = 706/1630 (43%), Positives = 1065/1630 (65%), Gaps = 19/1630 (1%)
Query: 2 SDLPIEFTELVDLTSLGISPQYLDFRSTTFESDHFVTVRESSNGTNTVAIVDLTNGNEVT 61
++ PI E++ L S+GI Q++ F + T ESD ++ VRE++ N+V I+D+ +
Sbjct: 4 ANAPIIMKEVLTLPSVGIGQQFITFTNVTMESDKYICVRETAP-QNSVVIIDMNMPMQPL 62
Query: 62 RKNMGGDSAIMHPSQKVISVRAN--GTI---VQIFNLDTKSKLKSFQLDEPVIFWKWLSE 116
R+ + DSA+M+P+ ++++++A GT +QIFN++ K+KLKS Q+ E V FWKW++
Sbjct: 63 RRPITADSALMNPNSRILALKAQVPGTTQDHLQIFNIEAKAKLKSHQMPEQVAFWKWITP 122
Query: 117 DVLGFITANSLYVSNVFDGNVSAKPAKITDRHVNLNNTQIINFVANEKMDWFAVVGIIQE 176
+LG +T S+Y ++ +G+ ++P K+ DR NL N QIIN+ + W ++GI
Sbjct: 123 KMLGLVTQTSVYHWSI-EGD--SEPVKMFDRTANLANNQIINYKCSPNEKWLVLIGIAPG 179
Query: 177 NGK----IAGKIQLFSKTRGISQAIDGHVAIFSKILLDGNTEPVQVFVTGNRNVNTG--A 230
+ + + G +QLFS + SQA++ H A F++ + GN P + +++ N G
Sbjct: 180 SPERPQLVKGNMQLFSVDQQRSQALEAHAASFAQFKVPGNENPSILISFASKSFNAGQIT 239
Query: 231 GELRIIEIDPPQDQSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLY 290
+L +IE+ Q + KK D+FFP D +DFP+++QVS K+ +IYV+TK G + +Y
Sbjct: 240 SKLHVIELGA-QPGKPSFTKKQADLFFPPDFADDFPVAMQVSHKFNLIYVITKLGLLFVY 298
Query: 291 ELETGSNLFVNRITADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNV 350
+LET S ++ NRI+ D +F + + G IN++G VL ++ I+P++ +L+N+
Sbjct: 299 DLETASAIYRNRISPDPIFLTSEASSVGGFYAINRRGQVLLATVNEATIIPFISGQLNNL 358
Query: 351 SLALTMASRGGLPGADDLFEKQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQ 408
LA+ +A RG LPGA++L ++F L +Q Y AA++AA S Q LRT T+ K +++
Sbjct: 359 ELAVNLAKRGNLPGAENLVVQRFQELFAQTKYKEAAELAAESPQGILRTPDTVAKFQSVP 418
Query: 409 APPGSISPILLYFSTLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGD 468
G P+L YF TLL +GKLN YES+EL+R ++ QN+ L E +L EDKL+CSEELGD
Sbjct: 419 VQAGQTPPLLQYFGTLLTRGKLNSYESLELSRLVVNQNKKNLLENWLAEDKLECSEELGD 478
Query: 469 IVKPFDTTLALATYLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLRTN 528
+VK D LAL Y+KA PKV+A AE ++FDKIL YS +VGY P+++ L+ +LRT+
Sbjct: 479 LVKTVDNDLALKIYIKARATPKVVAAFAERREFDKILIYSKQVGYTPDYMFLLQTILRTD 538
Query: 529 PDKASEFAISLLSNPETASQLEVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTR 588
P A FA+ ++S E ++ I D+F +N I++ T+FLLD L+ N P+ LQT+
Sbjct: 539 PQGAVNFAL-MMSQMEGGCPVDYNTITDLFLQRNLIREATAFLLDVLKPNLPEHAFLQTK 597
Query: 589 VLEINLLNAPQVADAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHT 648
VLEINL+ P VADAIL N +FS+YD+P +A L EKAGLY ++L++YS++ DIKR IV+T
Sbjct: 598 VLEINLVTFPNVADAILANGMFSHYDRPRVAQLCEKAGLYIQSLKHYSELPDIKRVIVNT 657
Query: 649 SSIPADWLVDFFGKLNVEQSLACLKTLLDDNLEANLQIVIQVATKFSDLIGSQVLIKLFE 708
+I LV+FFG L+ E ++ C+K LL NL NLQI++QV ++ + +G IKLFE
Sbjct: 658 HAIEPQALVEFFGTLSSEWAMECMKDLLLVNLRGNLQIIVQVCAEYCEQLGVDACIKLFE 717
Query: 709 DYRSNEGLYYYLASLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFL 768
++S EGLY++L S ++++ D E+ FKYI+AA K G +EVER+ RE+N YD EK KNFL
Sbjct: 718 QFKSYEGLYFFLGSYLSMSEDPEIHFKYIEAAAKTGQIKEVERVTRESNFYDAEKTKNFL 777
Query: 769 KDAQLQDQMPLVVVCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVD 828
+A+L D PL+ VCDRF V DL YLY ++IE YVQ+VNP VV LLD +
Sbjct: 778 MEAKLPDARPLINVCDRFGFVPDLTHYLYTNNMLRYIEGYVQKVNPGNAPLVVGQLLDDE 837
Query: 829 CDEKVITSLLDTVVGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIY 888
C E I L+ +V +P++ L AE EKRNR G+Q+ V+N L KI
Sbjct: 838 CPEDFIKGLILSVRSLLPVEPLVAECEKRNRLRLLTQFLEHLVSEGSQDVHVHNALGKII 897
Query: 889 IDSNNSPEKFLKENDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQ 948
IDSNN+PE FL N YD+ VG+YCEKRDP LA +AY +GQ D++LI +TN+NS++K Q
Sbjct: 898 IDSNNNPEHFLTTNPYYDSKVVGKYCEKRDPTLAVVAYRRGQCDEELINVTNKNSLFKLQ 957
Query: 949 ARYLLARSNSDLWNIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTX 1008
ARY++ R + DLW VL+ +N +RRQL+D V+S +PE PE VS V+AFM+ L
Sbjct: 958 ARYVVERMDGDLWEKVLTEENEYRRQLIDQVVSTALPESKSPEQVSAAVKAFMTADLPHE 1017
Query: 1009 XXXXXXXXXXXPSPFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENE 1068
S F+ N LQ LL+L+AI+ +P++V I +LD++D + + ++ +
Sbjct: 1018 LIELLEKIVLQNSAFSGNFNLQNLLILTAIKADPSRVMDYINRLDNFDGPAVGEVAVDAQ 1077
Query: 1069 LNEEAFEIYDKHGKHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPE 1128
L EEAF I+ K + +A+ V+++++ ++RA +A ++ +WSQ+ A+L + +
Sbjct: 1078 LYEEAFAIFKKFNLNVQAVNVLLDNVRSIERAVEFAFRVEEDAVWSQVAKAQLREGLVSD 1137
Query: 1129 AIDSYIKAKDPSNFMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKL 1188
AI+S+I+A D + F+ VI+A+ED +++LV YLLM R+ +KEP +D LI AYA++ +L
Sbjct: 1138 AIESFIRADDTTQFLEVIRASEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIERL 1197
Query: 1189 NEIENLLSVSTVANLEEVGDKLSQHNDYKAAKLCYSSISNYSKLASTLVYLGDYQNAVDT 1248
EIE + + VANL+ VGD+L Y+AAK+ Y+ ISN++KLA TLV L +Q AVD
Sbjct: 1198 GEIEEFILMPNVANLQHVGDRLYDEALYEAAKIIYAFISNWAKLAVTLVKLQQFQGAVDA 1257
Query: 1249 ARKASNVKVWRQVNDACISNKEFRLAQICGLNLVVHAEELDELVAVYEHNGYFEELISLF 1308
ARKA++ K W++V AC+ +EFRLAQICGLN+++ ++L+E+ Y++ G F ELISL
Sbjct: 1258 ARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISLM 1317
Query: 1309 EAGLGLERAHMGMFTELAILYTKYNPSKTYEHLKLFWSRINIPKVIRAVEDAHLWPELIF 1368
E+GLGLERAHMG+FTEL +LY +Y K EH+KLF +R+NIPK+IRA ++ W EL +
Sbjct: 1318 ESGLGLERAHMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELTY 1377
Query: 1369 LYAHYDEWDNAALTMIEKSAYNFDHSYFKEIIVKVSNLEIYYKAINFYVKEHPSLLVDLL 1428
LY YDE+DNAA T++ S ++H FK+I+ KV+N+E+YYKA++FY++EHP ++ DLL
Sbjct: 1378 LYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDLL 1437
Query: 1429 TVLIPRLDIPRTVRIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEVDYKALQDA 1488
VL RLD R V I K+ +L LIKP+++ V N S VN+A +++ EE DY L+++
Sbjct: 1438 NVLALRLDHTRVVDIMRKAGHLRLIKPYMVAVQSNNVSAVNEALNEIYAEEEDYDRLRES 1497
Query: 1489 VSSYDKFDQLELATRLENHEIIFFKIIAAELYRRNKKWAKSLAIFKGEQLWKHAIETAAI 1548
+ +D FDQ+ LA ++E HE++ + +AA +Y++ +W +S+A+ K + ++K +ETA+
Sbjct: 1498 IDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETASQ 1557
Query: 1549 SQSQQIAEDLLSFFIETDNKEGFIALLYSCYHLITYDTVLEQAWLNNLETFIKPYEISVK 1608
S +AE LL +FIE KE F L+ CY LI D LE AW+NN+ F PY +
Sbjct: 1558 SGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQFI 1617
Query: 1609 KEQNDAIKQL 1618
+E + + +L
Sbjct: 1618 REYSGKVDEL 1627
>At3g08530 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1516
Score = 1267 bits (3279), Expect = 0.0
Identities = 640/1442 (44%), Positives = 950/1442 (65%), Gaps = 9/1442 (0%)
Query: 184 IQLFSKTRGISQAIDGHVAIFSKILLDGNTEPVQVFVTGNRNVNTG--AGELRIIEIDPP 241
+QLFS + SQA++ H A F++ + GN P + +++ N G +L +IE+
Sbjct: 1 MQLFSVDQQRSQALEAHAASFAQFKVPGNENPSILISFASKSFNAGQITSKLHVIELGA- 59
Query: 242 QDQSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLYELETGSNLFVN 301
Q + KK D+FFP D +DFP+++QVS K+ +IYV+TK G + +Y+LET S ++ N
Sbjct: 60 QPGKPSFTKKQADLFFPPDFADDFPVAMQVSHKFNLIYVITKLGLLFVYDLETASAIYRN 119
Query: 302 RITADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNVSLALTMASRGG 361
RI+ D +F + + G IN++G VL ++ I+P++ +L+N+ LA+ +A RG
Sbjct: 120 RISPDPIFLTSEASSVGGFYAINRRGQVLLATVNEATIIPFISGQLNNLELAVNLAKRGN 179
Query: 362 LPGADDLFEKQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQAPPGSISPILL 419
LPGA++L ++F L +Q Y AA++AA S Q LRT T+ K +++ G P+L
Sbjct: 180 LPGAENLVVQRFQELFAQTKYKEAAELAAESPQGILRTPDTVAKFQSVPVQAGQTPPLLQ 239
Query: 420 YFSTLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPFDTTLAL 479
YF TLL +GKLN YES+EL+R ++ QN+ L E +L EDKL+CSEELGD+VK D LAL
Sbjct: 240 YFGTLLTRGKLNSYESLELSRLVVNQNKKNLLENWLAEDKLECSEELGDLVKTVDNDLAL 299
Query: 480 ATYLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLRTNPDKASEFAISL 539
Y+KA PKV+A AE ++FDKIL YS +VGY P+++ L+ +LRT+P A FA+ +
Sbjct: 300 KIYIKARATPKVVAAFAERREFDKILIYSKQVGYTPDYLFLLQTILRTDPQGAVNFAL-M 358
Query: 540 LSNPETASQLEVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTRVLEINLLNAPQ 599
+S E S ++ I D+F +N I++ TSFLLD L+ N P+ LQT+VLEINL+ P
Sbjct: 359 MSQMEGGSPVDYNTITDLFLQRNLIREATSFLLDVLKPNLPEHAFLQTKVLEINLVTFPN 418
Query: 600 VADAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHTSSIPADWLVDF 659
VADA+L N +F++YD+P IA L EKAGLY ++L++YS++ DIKR IV+T +I LV+F
Sbjct: 419 VADAVLANGMFTHYDRPRIAQLCEKAGLYIQSLKHYSELPDIKRVIVNTHAIEPQALVEF 478
Query: 660 FGKLNVEQSLACLKTLLDDNLEANLQIVIQVA---TKFSDLIGSQVLIKLFEDYRSNEGL 716
FG L+ E ++ C+K LL NL NLQI++Q + ++ + +G IKLFE ++S EGL
Sbjct: 479 FGTLSSEWAMECMKDLLLVNLRGNLQIIVQASGACKEYCEQLGVDACIKLFEQFKSYEGL 538
Query: 717 YYYLASLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFLKDAQLQDQ 776
Y++L S ++++ D E+ FKYI+AA K G +EVER+ RE+N YD EK KNFL +A+L D
Sbjct: 539 YFFLGSYLSMSEDPEIHFKYIEAAAKTGQIKEVERVTRESNFYDAEKTKNFLMEAKLPDA 598
Query: 777 MPLVVVCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVDCDEKVITS 836
PL+ VCDRF+ V DL YLY ++IE YVQ+VNP VV LLD +C E I
Sbjct: 599 RPLINVCDRFSFVPDLTHYLYTNNMLRYIEGYVQKVNPGNAPLVVGQLLDDECPEDFIKG 658
Query: 837 LLDTVVGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIYIDSNNSPE 896
L+ +V +P++ L E EKRNR G+Q+ V+N L KI IDSNN+PE
Sbjct: 659 LILSVRSLLPVEPLVEECEKRNRLRLLTQFLEHLVSEGSQDVHVHNALGKIIIDSNNNPE 718
Query: 897 KFLKENDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLARS 956
FL N YD+ VG+YCEKRDP LA +AY +GQ D++LI +TN+NS++K QARY++ R
Sbjct: 719 HFLTTNPYYDSKVVGKYCEKRDPTLAVVAYRRGQCDEELINVTNKNSLFKLQARYVVERM 778
Query: 957 NSDLWNIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTXXXXXXXXX 1016
+ DLW+ VL +N +RRQL+D V+S +PE PE VS V+AFM+ L
Sbjct: 779 DGDLWDKVLDENNDYRRQLIDQVVSTALPESKSPEQVSAAVKAFMTADLPHELIELLEKI 838
Query: 1017 XXXPSPFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENELNEEAFEI 1076
S F+ N LQ LL+L+AI+ +P++V I +LD++D + + +E +L EEAF I
Sbjct: 839 VLQNSAFSGNFNLQNLLILTAIKADPSRVMDYINRLDNFDGPAVGEVAVEAQLYEEAFAI 898
Query: 1077 YDKHGKHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPEAIDSYIKA 1136
+ K + +A+ V+++++ ++RA +A ++ +WSQ+ A+L + +AI+S+I+A
Sbjct: 899 FKKFNLNVQAVNVLLDNVRSIERAVEFAFRVEEDSVWSQVAKAQLREGLVSDAIESFIRA 958
Query: 1137 KDPSNFMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKLNEIENLLS 1196
D ++F+ VI+ +ED +++LV YLLM R+ +KEP +D LI AYA++ +L EIE +
Sbjct: 959 DDATHFLEVIRVSEDTDVYDDLVKYLLMVRQKVKEPKVDSELIYAYAKIDRLGEIEEFIL 1018
Query: 1197 VSTVANLEEVGDKLSQHNDYKAAKLCYSSISNYSKLASTLVYLGDYQNAVDTARKASNVK 1256
+ VANL+ VGD+L Y+AAK+ Y+ ISN+ KLA TLV L +Q AVD ARKA++ K
Sbjct: 1019 MPNVANLQHVGDRLYDEALYEAAKIIYAFISNWGKLAVTLVKLQQFQGAVDAARKANSAK 1078
Query: 1257 VWRQVNDACISNKEFRLAQICGLNLVVHAEELDELVAVYEHNGYFEELISLFEAGLGLER 1316
W++V AC+ +EFRLAQICGLN+++ ++L+E+ Y++ G F ELISL E+GLGLER
Sbjct: 1079 TWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISLMESGLGLER 1138
Query: 1317 AHMGMFTELAILYTKYNPSKTYEHLKLFWSRINIPKVIRAVEDAHLWPELIFLYAHYDEW 1376
AHMG+FTEL +LY +Y K EH+KLF +R+NIPK+IRA ++ W EL +LY YDE+
Sbjct: 1139 AHMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELTYLYIQYDEF 1198
Query: 1377 DNAALTMIEKSAYNFDHSYFKEIIVKVSNLEIYYKAINFYVKEHPSLLVDLLTVLIPRLD 1436
DNAA T++ S ++H FK+I+ KV+N+E+YYKA++FY++EHP ++ DLL VL RLD
Sbjct: 1199 DNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDLLNVLALRLD 1258
Query: 1437 IPRTVRIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEVDYKALQDAVSSYDKFD 1496
R V I K+ +L LIKP++I V N S VN+A +++ +EE DY L++++ +D FD
Sbjct: 1259 HTRVVDIMRKAGHLRLIKPYMIAVQSNNVSAVNEALNEIYVEEEDYDRLRESIDLHDSFD 1318
Query: 1497 QLELATRLENHEIIFFKIIAAELYRRNKKWAKSLAIFKGEQLWKHAIETAAISQSQQIAE 1556
Q+ LA ++E HE++ + +AA +Y++ +W +S+A+ K + ++K +ETA+ S ++AE
Sbjct: 1319 QIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETASQSGEHELAE 1378
Query: 1557 DLLSFFIETDNKEGFIALLYSCYHLITYDTVLEQAWLNNLETFIKPYEISVKKEQNDAIK 1616
LL +FIE KE F L+ CY LI D LE AW+NN+ F PY + +E + +
Sbjct: 1379 QLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMMDFAFPYLLQFIREYSGKVD 1438
Query: 1617 QL 1618
+L
Sbjct: 1439 EL 1440
>Hs20561160 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 1285
Score = 1081 bits (2796), Expect = 0.0
Identities = 550/1205 (45%), Positives = 818/1205 (67%), Gaps = 10/1205 (0%)
Query: 4 LPIEFTELVDLTSLGISPQYLDFRSTTFESDHFVTVRESSNGTNTVAIVDLTNGNEVTRK 63
LP+ F E L +LGI+P + F + T ESD F+ +RE V I+D+++ R+
Sbjct: 5 LPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDMSDPMAPIRR 64
Query: 64 NMGGDSAIMHPSQKVISVRANGTIVQIFNLDTKSKLKSFQLDEPVIFWKWLSEDVLGFIT 123
+ +SAIM+P+ KVI+++A T+ QIFN++ KSK+K+ + E VIFWKW+S + + +T
Sbjct: 65 PISAESAIMNPASKVIALKAGKTL-QIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVT 123
Query: 124 ANSLYVSNVFDGNVSAKPAKITDRHVNLNNTQIINFVANEKMDWFAVVGIIQENGKIAGK 183
++Y ++ +G+ ++P K+ DRH +L Q+I++ +E W +VGI + ++ G
Sbjct: 124 ETAVYHWSM-EGD--SQPMKMFDRHTSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGA 180
Query: 184 IQLFSKTRGISQAIDGHVAIFSKILLDGNTEPVQVFVTGNRNVNTGAGELRIIEIDPPQD 243
+QL+S R +SQ I+GH A F++ ++GN +P +F RN G+L IIE+ P
Sbjct: 181 MQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPT--GGKLHIIEVGQPAA 238
Query: 244 QSVRYQKKIVDIFFPADAVNDFPISVQVSEKYGIIYVLTKYGFIHLYELETGSNLFVNRI 303
+ + KK VD+FFP +A NDFP+++Q+ K+G+IY++TKYG++HLY+LE+G + +NRI
Sbjct: 239 GNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRI 298
Query: 304 TADSVFTATYYNHKNGIACINKKGNVLAVEIDTTQIVPYVLNKLSNVSLALTMASRGGLP 363
+AD++F + +GI +NKKG VL+V ++ IV Y N L N L L +A R L
Sbjct: 299 SADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLA 358
Query: 364 GADDLFEKQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQAPPGSISPILLYF 421
GA+ LF ++F+ L +QG Y+ AAKVAAS+ + LRT+ T+ K ++I A G SP+L YF
Sbjct: 359 GAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYF 418
Query: 422 STLLDKGKLNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPFDTTLALAT 481
LLD+G+LN+ ES+EL +LQQ R QL EK+LKEDKL+CSEELGD+VK D LAL+
Sbjct: 419 GILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSV 478
Query: 482 YLKAEVHPKVIACLAELQQFDKILPYSAKVGYNPNFVVLISNLLRTNPDKASEFAISLLS 541
YL+A V KVI C AE QF KI+ Y+ KVGY P+++ L+ +++ +P++ +F+ L+
Sbjct: 479 YLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQ 538
Query: 542 NPETASQLEVEKIADIFFSQNYIQQGTSFLLDALRSNTPDQGHLQTRVLEINLLNAPQVA 601
+ E + + +I DIF + IQQ TSFLLDAL++N P +G LQT +LE+NL++APQVA
Sbjct: 539 DEEPLAN--ISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVA 596
Query: 602 DAILGNDIFSYYDKPTIAGLAEKAGLYQRALENYSDIKDIKRCIVHTSSIPADWLVDFFG 661
DAILGN +F++YD+ IA L EKAGL Q+ALE+Y+D+ DIKR +VHT + +WLV+FFG
Sbjct: 597 DAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFG 656
Query: 662 KLNVEQSLACLKTLLDDNLEANLQIVIQVATKFSDLIGSQVLIKLFEDYRSNEGLYYYLA 721
L+VE S+ CL +L N+ NLQ+ +QVA+K+ + +G+Q L++LFE ++S +GL+Y+L
Sbjct: 657 SLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLG 716
Query: 722 SLVNLTTDKEVVFKYIQAAVKAGHFQEVERIVRENNVYDPEKVKNFLKDAQLQDQMPLVV 781
S+VN + D +V KYIQAA K G +EVERI RE++ Y+PE+VKNFLK+A+L DQ+PL++
Sbjct: 717 SIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLII 776
Query: 782 VCDRFNMVHDLVLYLYRTKNFKFIEVYVQQVNPSKTAQVVAGLLDVDCDEKVITSLLDTV 841
VCDRF VHDLVLYLYR ++IE+YVQ+VNPS+T V+ GLLDVDC E+VI L+ V
Sbjct: 777 VCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAV 836
Query: 842 VGQVPIDELTAEVEKRNRXXXXXXXXXXXXQSGTQNQSVYNTLAKIYIDSNNSPEKFLKE 901
GQ DEL AEVEKRNR Q G + + +N LAKIYIDSNNSPE FL+E
Sbjct: 837 RGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRE 896
Query: 902 NDQYDTLNVGRYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLARSNSDLW 961
N YD+ VGRYCEKRDP+LA +AYE+GQ D +LI++ NENS++K +ARYL+ R + +LW
Sbjct: 897 NAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELW 956
Query: 962 NIVLSPDNIHRRQLVDAVISVGIPELTDPEPVSLTVQAFMSNGLKTXXXXXXXXXXXXPS 1021
VL N RRQL+D V+ + E DPE +S+TV+AFM+ L S
Sbjct: 957 AHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNS 1016
Query: 1022 PFNDNPALQGLLLLSAIRYEPNKVSGLIEKLDHYDVDEIAPLCIENELNEEAFEIYDKHG 1081
F+++ LQ LL+L+AI+ + +V I +LD+YD +IA + + + L EEAF ++ K
Sbjct: 1017 VFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFD 1076
Query: 1082 KHDKALKVIVEDLLMLDRAESYADKINTPELWSQLGTAELNALRIPEAIDSYIKAKDPSN 1141
+ A++V++E + LDRA +A++ N P +WSQL A+L + EAI+SYI+ DPS+
Sbjct: 1077 MNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSS 1136
Query: 1142 FMNVIKAAEDAGKFEELVPYLLMARESLKEPVIDGALILAYAELSKLNEIENLLSVSTVA 1201
++ V+++A + +E+LV +L MAR+ +E I+ LI A A+ S+++E+E+ ++ A
Sbjct: 1137 YLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNA 1196
Query: 1202 NLEEV 1206
+++++
Sbjct: 1197 HIQQL 1201
>Hs22042197 [U] KOG0985 Vesicle coat protein clathrin heavy chain
Length = 586
Score = 55.8 bits (133), Expect = 5e-07
Identities = 43/154 (27%), Positives = 74/154 (47%), Gaps = 17/154 (11%)
Query: 371 KQFDNLLSQGDYSNAAKVAASSQQ--LRTQATINKLKNIQAPPGSISPILLYFSTLLDKG 428
++F+ L+S G+Y AA AA+S + LR T+N K + G P+LL+F L
Sbjct: 299 ERFNELISLGEYEKAACYAANSPRRILRNIGTMNTFKAVGKIRGKPLPLLLFFEALFITS 358
Query: 429 K-----LNQYESIELTRPLLQQNRNQLYEKYLKEDKLQCSEELGDIVKPF---DT----- 475
++ ++E + L + R L ++ +++L SEE GD++ + DT
Sbjct: 359 HAFPCPVDAALTLEGIKCGLSEKRLDLVTNWVTQERLTFSEEAGDVICDYGEQDTYNKAK 418
Query: 476 --TLALATYLKAEVHPKVIACLAELQQFDKILPY 507
LA Y + +H K I CL + Q +++ Y
Sbjct: 419 CLALAQIVYSECGLHKKAILCLCKQGQTHRVMEY 452
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.135 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,159,459
Number of Sequences: 60738
Number of extensions: 4026017
Number of successful extensions: 11197
Number of sequences better than 1.0e-05: 11
Number of HSP's better than 0.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 11090
Number of HSP's gapped (non-prelim): 12
length of query: 1654
length of database: 30,389,216
effective HSP length: 120
effective length of query: 1534
effective length of database: 23,100,656
effective search space: 35436406304
effective search space used: 35436406304
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)