ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI2675 check: MH Z KOG3655 Cytoskeleton Drebrins and related actin binding proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI2675 946231 944504 -576
(576 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YCR088w [Z] KOG3655 Drebrins and related actin binding proteins 493 e-139
SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding prot... 82 2e-15
Hs5453710 [Z] KOG1702 Nebulin repeat protein 59 2e-08
SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH... 57 8e-08
CE18868 [Z] KOG3655 Drebrins and related actin binding proteins 57 8e-08
Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin 56 1e-07
7294461 [Z] KOG3655 Drebrins and related actin binding proteins 55 4e-07
HsM7661718 [Z] KOG3655 Drebrins and related actin binding proteins 54 5e-07
Hs5453758 [Z] KOG1702 Nebulin repeat protein 54 5e-07
Hs4758794 [Z] KOG1702 Nebulin repeat protein 54 5e-07
Hs21361670 [Z] KOG3655 Drebrins and related actin binding proteins 54 5e-07
Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA 54 6e-07
Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 53 1e-06
Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein 53 1e-06
Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein 53 1e-06
Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein 53 1e-06
SPBC21D10.12 [U] KOG3771 Amphiphysin 53 1e-06
Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin 53 1e-06
Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin 53 1e-06
Hs4885609 [T] KOG0197 Tyrosine kinases 52 2e-06
Hs22047742 [T] KOG0521 Putative GTPase activating proteins (GAPs) 52 2e-06
CE05763 [Z] KOG0162 Myosin class I heavy chain 52 2e-06
7294071 [Z] KOG1702 Nebulin repeat protein 51 4e-06
7301982 [T] KOG4348 Adaptor protein CMS/SETA 51 5e-06
Hs4885235 [T] KOG0197 Tyrosine kinases 50 7e-06
HsM4505263 [T] KOG0192 Tyrosine kinase specific for activated (G... 50 9e-06
Hs21735550 [T] KOG0192 Tyrosine kinase specific for activated (G... 50 9e-06
CE29545 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 50 9e-06
>YCR088w [Z] KOG3655 Drebrins and related actin binding proteins
Length = 592
Score = 493 bits (1269), Expect = e-139
Identities = 284/615 (46%), Positives = 346/615 (56%), Gaps = 66/615 (10%)
Query: 1 MAFEPIDTTTHSRAIEAEYLKVVKG-DPDTTWLIISPNSKKQYEPELVGTSFSEFLQSFD 59
MA EPID TTHSR I+AEYLK+V+G DPDTTWLIISPN+KK+YEPE G+SF +FLQ FD
Sbjct: 1 MALEPIDYTTHSREIDAEYLKIVRGSDPDTTWLIISPNAKKEYEPESTGSSFHDFLQLFD 60
Query: 60 DTKVQYGLARVSPPGSDVQKLILIGWCPDSAPLKTRASFAQNFGVISNQVFKTYHVQVTA 119
+TKVQYGLARVSPPGSDV+K+I+IGWCPDSAPLKTRASFA NF ++N +FK YHVQVTA
Sbjct: 61 ETKVQYGLARVSPPGSDVEKIIIIGWCPDSAPLKTRASFAANFAAVANNLFKGYHVQVTA 120
Query: 120 RXXXXXXXXXXXMKISNSAGARYSIQ----QQTPASKKPISSAAKTAKKPVSVSSRQSEQ 175
R MKISN+AGARYSIQ QQ AS P+ + +K P VS ++ +
Sbjct: 121 RDEDDLDENELLMKISNAAGARYSIQTSSKQQGKASTPPVKKSFTPSKSPAPVSKKEPVK 180
Query: 176 KEXXXXXXXXXXXXXXKTEKSRGKKDDEWGEPELEERDFDKKPLEPNSSSWKPIGKVDLQ 235
+ DD+W EPEL+ERDFD+ PL+PN SS+KPIGK+DLQ
Sbjct: 181 TPSPAPAAKISSRVNDNND------DDDWNEPELKERDFDQAPLKPNQSSYKPIGKIDLQ 234
Query: 236 KVIAEENSKEDPRLVVSGPNYDKKIDPQSEIAKLKQESKLKRDAEYNKVLG-PKXXXXXX 294
KVIAEE +KEDPRLV KIDP S+IA LK ESKLKRD+E+N LG K
Sbjct: 235 KVIAEEKAKEDPRLVQKPTAAGSKIDPSSDIANLKNESKLKRDSEFNSFLGTTKPPSMTE 294
Query: 295 XXXXXXXXKVIKGFKNEKSPAQLWAEKKGQKKPSNLENKTQRXXXXXXXXXXXXXXXXXX 354
KVIKGF+NEKSPAQLWAE+K ++ N E K +
Sbjct: 295 SSLKNDDDKVIKGFRNEKSPAQLWAERKAKQNSGNAETKAEAPKPEVPEDEPEGEPDVKD 354
Query: 355 VRSKFESI------------------KTKEIPIIKPSDSSRSRPQASKINSSDSWTKKQN 396
++SKFE + K E II P S+ + + K ++
Sbjct: 355 LKSKFEGLAASEKEEEEMENKFAPPPKKSEPTIISPKPFSKPQ-EPVKAEEAEQPKTDYK 413
Query: 397 KFGQPLPGLH------DQKKEQNDDWSSDXXXXXXXXXTPAPSLPVRRNVPPPPESDXXX 450
K G PLPG+H ++ +E +DDW D P PS V P E
Sbjct: 414 KIGNPLPGMHIEADNEEEPEENDDDWDDD---EDEAAQPPLPSRNVASGAPVQKEEP--- 467
Query: 451 XXXXXXXXXXXXXXXXXAPSLPTRRNV-----------XXXXXXXXXXXXXXXRAFSKSQ 499
APSLP+R ++ + S+S
Sbjct: 468 ------------EQEEIAPSLPSRNSIPAPKQEEAPEQAPEEEIEEEAEEAAPQLPSRSS 515
Query: 500 NTPPSPAPRASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELE 559
PP P RA+ K + P A AEYDY+A EDNELTF EN++IINI+FVDDDWWLGELE
Sbjct: 516 AAPPPPPRRATPEKKPKENPWATAEYDYDAAEDNELTFVENDKIINIEFVDDDWWLGELE 575
Query: 560 SSGEKGLFPSNYVNL 574
G KGLFPSNYV+L
Sbjct: 576 KDGSKGLFPSNYVSL 590
>SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding proteins
Length = 857
Score = 82.4 bits (202), Expect = 2e-15
Identities = 62/244 (25%), Positives = 102/244 (41%), Gaps = 30/244 (12%)
Query: 1 MAFEPIDTTTHSRAIEAEYLKVVKGDPDTTWLIISPNSKKQYEPELV--GTSFSEFLQSF 58
M+F+ +DT+TH I Y KV+ G D +W I + ++V G EFL F
Sbjct: 1 MSFQ-LDTSTHGAEIRNVYEKVLSGADDCSWAIFGYEKGQGNILKVVASGNDNDEFLDEF 59
Query: 59 DDTKVQYGLARVSPPGSDVQKLILIGWCPDSAPLKTRASFAQNFGVISNQVFKTYHVQVT 118
D+ V +G RV + + K +L+ WC ++A K F+ + +SN + K YHVQ+T
Sbjct: 60 DENAVLFGFLRVKDVNTGLNKFVLVCWCGEAAARK--GLFSIHMATVSN-LLKGYHVQIT 116
Query: 119 ARXXXXXXXXXXXMKISNSAGARYSI--QQQTPASK--------KPISSAAKTA------ 162
R ++++++G++YS+ TP SK + S AK A
Sbjct: 117 GRESSDLNMDDIIRRVADASGSKYSVHTSNSTPQSKHNAFYDASQTFGSTAKVAPAPAPS 176
Query: 163 --------KKPVSVSSRQSEQKEXXXXXXXXXXXXXXKTEKSRGKKDDEWGEPELEERDF 214
KPV + + S+ T R + W + +E+
Sbjct: 177 TKTPLANISKPVVQAQKDSKDNSWDDSSKQSNTQTANTTSNLRVPVNASWSDAGRKEKSQ 236
Query: 215 DKKP 218
+ KP
Sbjct: 237 ENKP 240
Score = 71.6 bits (174), Expect = 3e-12
Identities = 39/77 (50%), Positives = 50/77 (64%), Gaps = 8/77 (10%)
Query: 496 SKSQNTPPSPAPRASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWL 555
+++ N PP+ P+A PGK S A YDY+A EDNEL+F E+E I N+ VD +WW
Sbjct: 786 NETANNPPAE-PQAGGPGK-----SVKAIYDYQAQEDNELSFFEDEIIANVDCVDPNWWE 839
Query: 556 GELESSGEKGLFPSNYV 572
GE G +GLFPSNYV
Sbjct: 840 GECH--GHRGLFPSNYV 854
Score = 67.4 bits (163), Expect = 6e-11
Identities = 31/54 (57%), Positives = 39/54 (71%), Gaps = 1/54 (1%)
Query: 521 AIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYVNL 574
AI YDY E+NE+ ENE+I ++FVDD WWLGE S G++GLFPSNYV +
Sbjct: 730 AIVIYDYSPEEENEIELVENEQIQILEFVDDGWWLGE-NSKGQQGLFPSNYVEI 782
>Hs5453710 [Z] KOG1702 Nebulin repeat protein
Length = 261
Score = 59.3 bits (142), Expect = 2e-08
Identities = 27/72 (37%), Positives = 45/72 (62%), Gaps = 3/72 (4%)
Query: 502 PPSPAP-RASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELES 560
P +P + S PG G A YDY A +++E++F++ + I+N+Q +DD W G +E
Sbjct: 189 PAAPVSIQRSAPGG--GGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVER 246
Query: 561 SGEKGLFPSNYV 572
+G+ G+ P+NYV
Sbjct: 247 TGDTGMLPANYV 258
>SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 296
Score = 57.0 bits (136), Expect = 8e-08
Identities = 32/84 (38%), Positives = 48/84 (57%), Gaps = 9/84 (10%)
Query: 496 SKSQNTPPSPAPRASKPGKKESGPSA---IAEYDYEAGEDNELTFEENERIINIQFVDDD 552
S ++ PP P S PG + + +A YD+ + +L F E II ++ V++D
Sbjct: 121 SSTEKLPPPP----SYPGPNTAHKNVERVLAMYDFPGPDAGDLGFHAGEVIIVLEHVNND 176
Query: 553 WWLGELESSGEKGLFPSNYVNLEE 576
WW GEL +G++G+FPSNYV L E
Sbjct: 177 WWRGEL--NGKEGIFPSNYVRLLE 198
>CE18868 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 643
Score = 57.0 bits (136), Expect = 8e-08
Identities = 31/77 (40%), Positives = 44/77 (56%), Gaps = 7/77 (9%)
Query: 504 SPAPRASKPGKKESGPSAIAE------YDYEAGEDNELTFEENERIINIQFVDDDWWLGE 557
SP A+ P + P A+AE +DY+A +D E++F+ ++ I +I VD WW G
Sbjct: 567 SPIKVAAPPIDQYDFPPAVAEQNAMALWDYQAADDTEISFDPDDIITDIDQVDSGWWKGR 626
Query: 558 LESSGEKGLFPSNYVNL 574
SG GLFP+NYV L
Sbjct: 627 -APSGRVGLFPANYVKL 642
>Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1221
Score = 56.2 bits (134), Expect = 1e-07
Identities = 32/81 (39%), Positives = 47/81 (57%), Gaps = 4/81 (4%)
Query: 494 AFSKSQNTPPSPAPRASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDW 553
AF+ + T SP+P + G+K G A A Y + A +DN L F +N+ +I + D W
Sbjct: 892 AFTPATATGSSPSPVLGQ-GEKVEGLQAQALYPWRAKKDNHLNFNKND-VITVLEQQDMW 949
Query: 554 WLGELESSGEKGLFPSNYVNL 574
W GE++ G+KG FP +YV L
Sbjct: 950 WFGEVQ--GQKGWFPKSYVKL 968
Score = 54.7 bits (130), Expect = 4e-07
Identities = 31/77 (40%), Positives = 45/77 (58%), Gaps = 7/77 (9%)
Query: 503 PSPAPRASKPGKKE--SGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELES 560
P+ R + P K SG IA Y YE+ E +LTF++ + +I + D DWW G +
Sbjct: 987 PASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKDGDWWTGTV-- 1043
Query: 561 SGEK-GLFPSNYVNLEE 576
G+K G+FPSNYV L++
Sbjct: 1044 -GDKAGVFPSNYVRLKD 1059
Score = 52.8 bits (125), Expect = 1e-06
Identities = 26/53 (49%), Positives = 33/53 (62%), Gaps = 2/53 (3%)
Query: 522 IAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYVNL 574
I YDY A D+EL F + + I + D DWW GE+ +G+ GLFPSNYV L
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVKL 1211
>7294461 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 531
Score = 54.7 bits (130), Expect = 4e-07
Identities = 25/57 (43%), Positives = 36/57 (62%), Gaps = 1/57 (1%)
Query: 518 GPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYVNL 574
G A A YDY+A ++ E+TF+ + I +I +D+ WW G L G GLFP+NYV +
Sbjct: 474 GQRARALYDYQAADETEITFDPGDVITHIDQIDEGWWQG-LGPDGTYGLFPANYVEI 529
>HsM7661718 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 430
Score = 54.3 bits (129), Expect = 5e-07
Identities = 26/64 (40%), Positives = 36/64 (55%), Gaps = 1/64 (1%)
Query: 513 GKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYV 572
G G A A YDY+A +D E++F+ I I+ +D+ WW G G G+FP+NYV
Sbjct: 368 GLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG-YGPDGHFGMFPANYV 426
Query: 573 NLEE 576
L E
Sbjct: 427 ELIE 430
Score = 52.0 bits (123), Expect = 2e-06
Identities = 43/205 (20%), Positives = 80/205 (38%), Gaps = 7/205 (3%)
Query: 14 AIEAEYLKVVKGDPDTTWLIISPNSKKQYEPELVGTS---FSEFLQSFDDTKVQYGLARV 70
A++ Y++VV T W + + + + GT E ++ + KV Y RV
Sbjct: 11 ALQEAYVRVVTEKSPTDWALFTYEGNSN-DIRVAGTGEGGLEEMVEELNSGKVMYAFCRV 69
Query: 71 SPPGSDVQKLILIGWCPDSAPLKTRASFAQNFGVISNQVFKTYHVQVTARXXXXXXXXXX 130
P S + K +LI W + + + A + +++ K HV + AR
Sbjct: 70 KDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMAS-FLKGAHVTINARAEEDVEPECI 128
Query: 131 XMKISNSAGARYSIQQQTPASKK--PISSAAKTAKKPVSVSSRQSEQKEXXXXXXXXXXX 188
K++ ++GA YS +++ + P + +K +VS + K+
Sbjct: 129 MEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEE 188
Query: 189 XXXKTEKSRGKKDDEWGEPELEERD 213
EK R ++ E E ER+
Sbjct: 189 NRRLEEKRRAEEAQRQLEQERRERE 213
>Hs5453758 [Z] KOG1702 Nebulin repeat protein
Length = 1014
Score = 54.3 bits (129), Expect = 5e-07
Identities = 19/50 (38%), Positives = 35/50 (70%)
Query: 523 AEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYV 572
A YDY A +++E++F + + I+N+Q +DD W G ++ +G G+ P+NY+
Sbjct: 961 AMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYI 1010
>Hs4758794 [Z] KOG1702 Nebulin repeat protein
Length = 6669
Score = 54.3 bits (129), Expect = 5e-07
Identities = 27/88 (30%), Positives = 47/88 (52%), Gaps = 12/88 (13%)
Query: 497 KSQNTPPSPAPRASKPGKKESGPSAI------------AEYDYEAGEDNELTFEENERII 544
K T P R+S +++ S+I A YDY A + +E++F++ + II
Sbjct: 6579 KHAKTTELPQQRSSSVATQQTTVSSIPSHPSTAGKIFRAMYDYMAADADEVSFKDGDAII 6638
Query: 545 NIQFVDDDWWLGELESSGEKGLFPSNYV 572
N+Q +D+ W G ++ +G G+ P+NYV
Sbjct: 6639 NVQAIDEGWMYGTVQRTGRTGMLPANYV 6666
>Hs21361670 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 431
Score = 54.3 bits (129), Expect = 5e-07
Identities = 26/64 (40%), Positives = 36/64 (55%), Gaps = 1/64 (1%)
Query: 513 GKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYV 572
G G A A YDY+A +D E++F+ I I+ +D+ WW G G G+FP+NYV
Sbjct: 369 GLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG-YGPDGHFGMFPANYV 427
Query: 573 NLEE 576
L E
Sbjct: 428 ELIE 431
Score = 52.0 bits (123), Expect = 2e-06
Identities = 43/205 (20%), Positives = 80/205 (38%), Gaps = 7/205 (3%)
Query: 14 AIEAEYLKVVKGDPDTTWLIISPNSKKQYEPELVGTS---FSEFLQSFDDTKVQYGLARV 70
A++ Y++VV T W + + + + GT E ++ + KV Y RV
Sbjct: 11 ALQEAYVRVVTEKSPTDWALFTYEGNSN-DIRVAGTGEGGLEEMVEELNSGKVMYAFCRV 69
Query: 71 SPPGSDVQKLILIGWCPDSAPLKTRASFAQNFGVISNQVFKTYHVQVTARXXXXXXXXXX 130
P S + K +LI W + + + A + +++ K HV + AR
Sbjct: 70 KDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMAS-FLKGAHVTINARAEEDVEPECI 128
Query: 131 XMKISNSAGARYSIQQQTPASKK--PISSAAKTAKKPVSVSSRQSEQKEXXXXXXXXXXX 188
K++ ++GA YS +++ + P + +K +VS + K+
Sbjct: 129 MEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEE 188
Query: 189 XXXKTEKSRGKKDDEWGEPELEERD 213
EK R ++ E E ER+
Sbjct: 189 NRRLEEKRRAEEAQRQLEQERRERE 213
>Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA
Length = 665
Score = 53.9 bits (128), Expect = 6e-07
Identities = 25/52 (48%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 521 AIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYV 572
AI E+DY+A D+ELT E I NI+ D WW G++ +G +GLFP N+V
Sbjct: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQI--NGRRGLFPDNFV 53
>Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 540
Score = 53.1 bits (126), Expect = 1e-06
Identities = 28/71 (39%), Positives = 37/71 (51%), Gaps = 2/71 (2%)
Query: 505 PAPRASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEK 564
P+ + + G A YD+EA EDNELTF+ E I + D +WW GE
Sbjct: 199 PSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQG--I 256
Query: 565 GLFPSNYVNLE 575
GLFPSN+V +
Sbjct: 257 GLFPSNFVTAD 267
>Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 666
Score = 53.1 bits (126), Expect = 1e-06
Identities = 25/76 (32%), Positives = 45/76 (58%), Gaps = 2/76 (2%)
Query: 501 TPPSPAPRASKPGKKESGP--SAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGEL 558
TPP A A P + G AIA+Y++ A + EL+ + +R+I ++ VD +W+ G++
Sbjct: 487 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 546
Query: 559 ESSGEKGLFPSNYVNL 574
+ +G+FP +YV +
Sbjct: 547 PGTNRQGIFPVSYVEV 562
>Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 790
Score = 53.1 bits (126), Expect = 1e-06
Identities = 27/70 (38%), Positives = 38/70 (53%), Gaps = 2/70 (2%)
Query: 503 PSPAPRASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSG 562
P PA S G A A YD+ ++EL+F+ + I ++ VDDDW GEL G
Sbjct: 717 PCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MG 774
Query: 563 EKGLFPSNYV 572
+ G+FP NY+
Sbjct: 775 KSGIFPKNYI 784
>Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 1100
Score = 53.1 bits (126), Expect = 1e-06
Identities = 25/76 (32%), Positives = 45/76 (58%), Gaps = 2/76 (2%)
Query: 501 TPPSPAPRASKPGKKESGP--SAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGEL 558
TPP A A P + G AIA+Y++ A + EL+ + +R+I ++ VD +W+ G++
Sbjct: 921 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 980
Query: 559 ESSGEKGLFPSNYVNL 574
+ +G+FP +YV +
Sbjct: 981 PGTNRQGIFPVSYVEV 996
>SPBC21D10.12 [U] KOG3771 Amphiphysin
Length = 466
Score = 52.8 bits (125), Expect = 1e-06
Identities = 29/76 (38%), Positives = 42/76 (55%), Gaps = 9/76 (11%)
Query: 502 PPSPAPRASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVD--DDWWLGELE 559
PP+PAP A+ + +A YDY A +L+F +RI + D ++WW+G L
Sbjct: 398 PPAPAPAAAPAAEH-----VVALYDYAAQAAGDLSFHAGDRIEVVSRTDNQNEWWIGRL- 451
Query: 560 SSGEKGLFPSNYVNLE 575
+G +G FP NYV LE
Sbjct: 452 -NGAQGQFPGNYVQLE 466
>Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 223
Score = 52.8 bits (125), Expect = 1e-06
Identities = 26/53 (49%), Positives = 33/53 (62%), Gaps = 2/53 (3%)
Query: 522 IAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYVNL 574
I YDY A D+EL F + + I + D DWW GE+ +G+ GLFPSNYV L
Sbjct: 164 IGMYDYTAQNDDELAFNKGQIINILNKEDPDWWKGEV--NGQVGLFPSNYVKL 214
Score = 50.8 bits (120), Expect = 5e-06
Identities = 32/95 (33%), Positives = 49/95 (50%), Gaps = 13/95 (13%)
Query: 493 RAFSKSQNTPPSPAPRASKPGKKE---------SGPSAIAEYDYEAGEDNELTFEENERI 543
R F + P P RA+ G + SG IA Y Y++ E +LTF++ + I
Sbjct: 44 RPFWADSSVPTWPPSRATVQGFDKNTWTAKPVVSGEEFIAMYTYQSSEQGDLTFQQGDVI 103
Query: 544 INIQFVD-DDWWLGELESSGEK---GLFPSNYVNL 574
+ + ++ WW GEL++ G+K G FP+NYV L
Sbjct: 104 LVTKKMNPGGWWEGELQARGKKRQIGWFPANYVKL 138
>Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1177
Score = 52.8 bits (125), Expect = 1e-06
Identities = 27/54 (50%), Positives = 37/54 (68%), Gaps = 4/54 (7%)
Query: 522 IAEYDYEAGEDNELTFEENERIINIQFVDD-DWWLGELESSGEKGLFPSNYVNL 574
IA YDY A ++EL+F + + +IN+ DD DWW GE+ +G GLFPSNYV +
Sbjct: 1117 IAMYDYAANNEDELSFSKGQ-LINVMNKDDPDWWQGEI--NGVTGLFPSNYVKM 1167
>Hs4885609 [T] KOG0197 Tyrosine kinases
Length = 536
Score = 52.0 bits (123), Expect = 2e-06
Identities = 21/51 (41%), Positives = 33/51 (64%)
Query: 522 IAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYV 572
+A YDYE+ + +L+F++ ER+ + + DWWL S+G+ G PSNYV
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140
>Hs22047742 [T] KOG0521 Putative GTPase activating proteins (GAPs)
Length = 652
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/79 (36%), Positives = 42/79 (52%), Gaps = 5/79 (6%)
Query: 501 TPPSPAPRASKPGKKESGPSAIAE----YDYEAGEDNELTFEENERIINIQFVDDDWWLG 556
TP P P K +G + + YD +A D+ELTF E E II D +WW+G
Sbjct: 571 TPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIG 630
Query: 557 ELESSGE-KGLFPSNYVNL 574
+E E KG+FP ++V++
Sbjct: 631 HIEGQPERKGVFPVSFVHI 649
>CE05763 [Z] KOG0162 Myosin class I heavy chain
Length = 1100
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/71 (38%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Query: 502 PPSPAPRASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESS 561
PP+ P+ P K + P IA Y YEA + +EL+FE I + WW G++ +
Sbjct: 1030 PPARGPKPPPPAKPKLNPVVIAVYPYEAQDVDELSFEAGAEIELMNKDASGWWQGKV--N 1087
Query: 562 GEKGLFPSNYV 572
GLFP NYV
Sbjct: 1088 NRVGLFPGNYV 1098
>7294071 [Z] KOG1702 Nebulin repeat protein
Length = 594
Score = 51.2 bits (121), Expect = 4e-06
Identities = 27/86 (31%), Positives = 44/86 (50%), Gaps = 10/86 (11%)
Query: 497 KSQNTPPSPAPRASKPG-----KKESGPSAI-----AEYDYEAGEDNELTFEENERIINI 546
+ Q PP +P +K+S S A YDYEA + +E++F E + I +
Sbjct: 504 QQQEHPPQQQQMRQQPSYSSLQEKQSRQSTAMRVYRAIYDYEAQDVDEVSFREGDVIFEV 563
Query: 547 QFVDDDWWLGELESSGEKGLFPSNYV 572
+ +D W G +E +G+ G+ P+NYV
Sbjct: 564 ESIDSGWMTGRVERTGKTGMLPANYV 589
>7301982 [T] KOG4348 Adaptor protein CMS/SETA
Length = 352
Score = 50.8 bits (120), Expect = 5e-06
Identities = 24/61 (39%), Positives = 36/61 (58%)
Query: 516 ESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYVNLE 575
E+ AI EY+Y A E +EL ++ I I+ + WW G L++SG G+FP N+V +
Sbjct: 2 ENNICAIVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVRVL 61
Query: 576 E 576
E
Sbjct: 62 E 62
>Hs4885235 [T] KOG0197 Tyrosine kinases
Length = 529
Score = 50.4 bits (119), Expect = 7e-06
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 522 IAEYDYEAGEDNELTFEENERIINIQFVDDDWWLGELESSGEKGLFPSNYV 572
IA YDYEA +++LTF + E+ + + DWW SSG+ G PSNYV
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYV 133
>HsM4505263 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 953
Score = 50.1 bits (118), Expect = 9e-06
Identities = 28/69 (40%), Positives = 37/69 (53%), Gaps = 6/69 (8%)
Query: 509 ASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQ-----FVDDDWWLGELESSGE 563
A + G +GP A +DYEA D ELT +R+ + D+ WW G+L SG
Sbjct: 9 AKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQL-PSGR 67
Query: 564 KGLFPSNYV 572
G+FPSNYV
Sbjct: 68 VGVFPSNYV 76
>Hs21735550 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 954
Score = 50.1 bits (118), Expect = 9e-06
Identities = 28/69 (40%), Positives = 37/69 (53%), Gaps = 6/69 (8%)
Query: 509 ASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQ-----FVDDDWWLGELESSGE 563
A + G +GP A +DYEA D ELT +R+ + D+ WW G+L SG
Sbjct: 9 AKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQL-PSGR 67
Query: 564 KGLFPSNYV 572
G+FPSNYV
Sbjct: 68 VGVFPSNYV 76
>CE29545 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 469
Score = 50.1 bits (118), Expect = 9e-06
Identities = 30/80 (37%), Positives = 42/80 (52%), Gaps = 2/80 (2%)
Query: 493 RAFSKSQNTPPSPAPRASKPGKKESGPSAIAEYDYEAGEDNELTFEENERIINIQFVDDD 552
R S S + PPS ++ E YDY+A +++ELT EN + ++ DDD
Sbjct: 389 RTESYSSSQPPSLFDTSAGWMPNEYLEKVRVLYDYDAAKEDELTLRENAIVYVLKKNDDD 448
Query: 553 WWLGELESSGEKGLFPSNYV 572
W+ G L+ G GLFP NYV
Sbjct: 449 WYEGVLD--GVTGLFPGNYV 466
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.307 0.127 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,941,612
Number of Sequences: 60738
Number of extensions: 1310951
Number of successful extensions: 4248
Number of sequences better than 1.0e-05: 28
Number of HSP's better than 0.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 4169
Number of HSP's gapped (non-prelim): 59
length of query: 576
length of database: 30,389,216
effective HSP length: 112
effective length of query: 464
effective length of database: 23,586,560
effective search space: 10944163840
effective search space used: 10944163840
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)