ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI2759 check: MH E KOG1288 Amino acid transport and metabolism Amino acid transporters
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI2759 974453 971181 -1091
(1091 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBR235w [E] KOG1288 Amino acid transporters 1225 0.0
SPBC18H10.16 [E] KOG1288 Amino acid transporters 644 0.0
Hs9910386 [E] KOG1288 Amino acid transporters 384 e-106
CE18193 [E] KOG1288 Amino acid transporters 376 e-103
7298458 [E] KOG1288 Amino acid transporters 365 e-100
CE19086_2 [P] KOG2083 Na+/K+ symporter 248 4e-65
7294587 [P] KOG2083 Na+/K+ symporter 244 4e-64
Hs4506975 [P] KOG2083 Na+/K+ symporter 242 2e-63
Hs4557849 [P] KOG2083 Na+/K+ symporter 234 7e-61
Hs4506977 [P] KOG2083 Na+/K+ symporter 230 8e-60
At1g30450_1 [P] KOG2082 K+/Cl- cotransporter KCC1 and related tr... 226 2e-58
7296739 [P] KOG2083 Na+/K+ symporter 217 9e-56
CE25033 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transp... 170 1e-41
Hs4827006 [P] KOG2082 K+/Cl- cotransporter KCC1 and related tran... 152 3e-36
Hs4826780 [P] KOG2082 K+/Cl- cotransporter KCC1 and related tran... 152 4e-36
7290145 [P] KOG2083 Na+/K+ symporter 147 7e-35
Hs11968148 [P] KOG2082 K+/Cl- cotransporter KCC1 and related tra... 138 4e-32
Hs5730043 [P] KOG2082 K+/Cl- cotransporter KCC1 and related tran... 137 1e-31
CE04838 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transp... 118 4e-26
CE04364 [P] KOG2083 Na+/K+ symporter 101 7e-21
CE02791 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transp... 97 1e-19
7291676 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transp... 90 2e-17
>YBR235w [E] KOG1288 Amino acid transporters
Length = 1120
Score = 1225 bits (3170), Expect = 0.0
Identities = 637/1128 (56%), Positives = 802/1128 (70%), Gaps = 46/1128 (4%)
Query: 1 MSKFYELPGSHLPSQS-----ERSPLLK-RRSSLTYFKYQDTPLQQEQSSKYDLENPHRN 54
+S+FY++PG+H PS + E S LL RR S TYF YQ TP Q+ SSKYD +NP+++
Sbjct: 2 VSRFYQIPGTHRPSSAISSSNESSSLLSARRISQTYFNYQATPECQKVSSKYDPDNPNKD 61
Query: 55 KLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAIST 114
KLGT+DGVF+PT LNVLSILMFLRFGFI+GQ+GI+ T LL+LS+ I++ TTLSISAIST
Sbjct: 62 KLGTYDGVFVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLSYTINLLTTLSISAIST 121
Query: 115 NGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISE---- 170
NGTVRGGGAYYMISR LGPE N+GMN VGI+EPLLYN G S
Sbjct: 122 NGTVRGGGAYYMISRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPLLYNLGYSAQGEP 181
Query: 171 -GVLTQVLPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVL 229
L ++LP GHW++F Y+TV+L LC +VA +GSQTVSRAGN+LF +L AS SIP+S L
Sbjct: 182 PAALGELLPRGHWHEFTYATVILFLCFSVAFVGSQTVSRAGNILFLVLAASIFSIPLSAL 241
Query: 230 FVKPFELNGIVYTGPSLQILKQNLYPKFTKGAAGSVLKGYETFNDLFGIFFPATAGIFAG 289
PF GI YTGPS Q NL P TKGAAGS+LKG ETFNDLFG+FFPATAGIFAG
Sbjct: 242 IRSPFTEGGISYTGPSWQTFHDNLLPHLTKGAAGSLLKGKETFNDLFGVFFPATAGIFAG 301
Query: 290 AGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKSLHKDVQIIQTVSGFQS 349
AGMSSELRKPSKSIPKGTLWGLL TF+CY++V+ S+GCS+P++SL+ +VQIIQT+S Q
Sbjct: 302 AGMSSELRKPSKSIPKGTLWGLLFTFICYAVVVFSMGCSIPRRSLYDEVQIIQTISSVQW 361
Query: 350 IILVGELSTSLFSVIVGMVGAAYVLEAISKDNILPGISIFGRNPVLCLLFSWFLTQMCLF 409
+I +GE++TSLFS+IVGM+GAAYVLEAI+KDNI+PG+ IF +P+ L+F+W LTQ+CLF
Sbjct: 362 VIFMGEMATSLFSIIVGMLGAAYVLEAIAKDNIIPGLEIFAHSPLYSLIFTWILTQLCLF 421
Query: 410 SDVNKIAXXXXXXXXXXXXXXNMACFLLEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMY 469
SDVNKIA N+ACFLL ISSAPNFRPSFK+FNRYT +GA+ ++AM
Sbjct: 422 SDVNKIATFITMTFLMTFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALLSVVAML 481
Query: 470 VVDNVSASAVISSLCLLFVIIHYFCPPKPWGDVSQSLIYHQVRKYLLRLRQDNVKYWRPQ 529
+VD +SAS + ++ LLF+ IHYF PPK WGDVSQSLIYHQVRKYLLRLRQDN+KYWRPQ
Sbjct: 482 IVDGISASVLFLAMILLFLFIHYFSPPKSWGDVSQSLIYHQVRKYLLRLRQDNIKYWRPQ 541
Query: 530 VLLMVDNPRTSWNLIKFCNHLKKGGLYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAG 589
+LL VDNPRTSWNLI+FCNHLKKGGLYILGHV V ++F + EL Q +AW+ IRDMA
Sbjct: 542 ILLFVDNPRTSWNLIRFCNHLKKGGLYILGHVAVTADFPKQLNELKTQQKAWMKIRDMAA 601
Query: 590 IKAFVQIGMGPTLPWGIRNVFMGSGLGGMKPNITVLGFFDLNNYLQKKRPHGVGASSPLR 649
IKAFVQ+G GP+L WGIRNVF+GSGLGGMKPNITV+GFFDL +Y +K + + L+
Sbjct: 602 IKAFVQVGTGPSLIWGIRNVFIGSGLGGMKPNITVVGFFDLESY--RKHIPQSRSQNNLQ 659
Query: 650 EDMNFRVTKYKDSISIEMPSHPEFESLPTDECKNEEKVKLQQWVQVIEDLSLMRSNIAVA 709
+ + + T + + S + P LPTDECKNE KV +QQWVQ++EDLSLM+SNIA+A
Sbjct: 660 KQVEIKATVPRSTCSDVKINVP----LPTDECKNETKVNVQQWVQIVEDLSLMQSNIAIA 715
Query: 710 YGFKNLQLPQKNETRDTKGYIDLYPIQMSATIVNENSSGEVTTTNFDTYTLILQLGAILT 769
+GFKNL++P K ++ K IDLYPIQM + + TTNFDTYTLILQL AIL
Sbjct: 716 HGFKNLEIPNKRDSCFPKKTIDLYPIQMCGKVEAKGDQPAAITTNFDTYTLILQLAAILV 775
Query: 770 TVPDWHRTHQLRVIVFVENERERYDEKKRIDALLSVLRIEAEVLVLSLDQFRVYNTIVKA 829
TVP+W RTH LRVI+FVE E R +E +R+ LL VLRI+AEVLV+SLDQFRVYNTIVK
Sbjct: 776 TVPEWKRTHSLRVILFVEQEYHRTNETQRMKKLLQVLRIDAEVLVVSLDQFRVYNTIVKG 835
Query: 830 DIIAKKCVDEALKNDDWWRELVDARTRQHSNRKFTTTEPTSIKINGNHLKKKYDVSNLQR 889
D I V+ L +++WW++LV+AR R+F+T EP +I +K S +Q+
Sbjct: 836 DPIVFDYVNSKLADNEWWKDLVEARDTLKPKRRFSTIEPQTIAKQFTQSRKY--TSGVQK 893
Query: 890 LGVSLTMASSMPA----TDMAGNESEYESDY-AVGAYESNSTLLSNGDQNQSIHPVRSMK 944
LGVS TM + MP T +S+ ++D ++ S ST +S G + S +
Sbjct: 894 LGVSFTMNTRMPTNRIDTPCESEDSDLDTDLTSIRDAFSASTNISVGKDLTTKSKTGSDR 953
Query: 945 A-------LDNASIRSNRPVFSSKAMPKTKVIEEATGQQPTLVPV--------------I 983
+ S +S RPVFSS +P+T+V+E+ TG+QPTL+P+ I
Sbjct: 954 TNLLVKNLQSDVSTQSLRPVFSSNTLPRTRVVEDGTGEQPTLIPIAEPDLSNGNGTGSGI 1013
Query: 984 DHTTDIKQNPVLHPISPCQSSADLTGSSDELTFNMLPSRVQHLILHDMMTQVXXXXXXXX 1043
+ +K+ PVL +SPC S L + L FN LPS QHL+L+D+MTQ+
Sbjct: 1014 GNGNKLKK-PVLPELSPCCSKDSLVTAMQNLGFNDLPSTAQHLVLNDVMTQMSKSSDLIF 1072
Query: 1044 XXXXXXXXGTHKNELASLEYVQNIDIWLDGLPPTILINSQSMTVTTAL 1091
GTH++ ASL+YV+++DIWL+GLPP +LINSQ+MTVTTAL
Sbjct: 1073 STLPVPALGTHEDHDASLQYVEDLDIWLEGLPPCMLINSQTMTVTTAL 1120
>SPBC18H10.16 [E] KOG1288 Amino acid transporters
Length = 1050
Score = 644 bits (1661), Expect = 0.0
Identities = 399/1112 (35%), Positives = 610/1112 (53%), Gaps = 122/1112 (10%)
Query: 22 LKRRSSLTYFKYQD-----TPLQQEQSSKYD----------------LENPHRN---KLG 57
L R S +++ Q+ TPL QE Y EN N KLG
Sbjct: 19 LSVRKSRRFWETQENLESSTPLLQEPQQSYRSNSFNELPPLSRSVTFAENEQPNEAVKLG 78
Query: 58 TFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAISTNGT 117
TF+G FIPTTLNVLSIL++LRF +IIG+ G+L T L+L +S+ + + T+LSISAI TNG
Sbjct: 79 TFEGCFIPTTLNVLSILLYLRFPWIIGEAGVLKTLLMLFISYAVGIFTSLSISAICTNGM 138
Query: 118 VRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLTQVL 177
VRGGGAYY +SR +GPE LN+GMNI G VEP++ FG G ++Q L
Sbjct: 139 VRGGGAYYAVSRSIGPELGGSIGLIFYVGQILNTGMNISGFVEPIISIFGKESGTISQFL 198
Query: 178 PEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVLFVKPFELN 237
PEG+W+ F Y+T +L +C + +GS ++A N LF +++ STISIPIS +FV PF+
Sbjct: 199 PEGYWWVFLYTTCVLAMCCILCCLGSAIFAKASNALFVVIILSTISIPISSIFVHPFKDP 258
Query: 238 GIV--YTGPSLQILKQNLYPKFTKGAAGSVLKGYETFNDLFGIFFPATAGIFAGAGMSSE 295
++ +TG L +NL +T+ G+ GYE+F FG+FFPATAG+ AGA MS +
Sbjct: 259 SLLVHFTGLKWSTLMKNLASAYTENEKGT---GYESFKSTFGVFFPATAGLLAGASMSGD 315
Query: 296 LRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKSLHKDVQIIQTVSGFQSIILVGE 355
L+ PS+SIPKGT+ TF+ Y LVI+ +G SV + L D+ +++ +S I+ G
Sbjct: 316 LKAPSRSIPKGTISSQATTFLLYLLVILCVGASVTRTGLLLDMDVMEHISLHPLFIISGI 375
Query: 356 LSTSLFSVIVGMVGAAYVLEAISKDNILPGISIFGRN------PVLCLLFSWFLTQMCLF 409
LS+ FS +G+ GAA +L+AI++D+++PG+ F + P + + ++ +TQ+ LF
Sbjct: 376 LSSGAFSSFMGIFGAAKLLQAIARDDLIPGMFFFAKGSSYDDIPYVAIGVTYLITQISLF 435
Query: 410 SDVNKIAXXXXXXXXXXXXXXNMACFLLEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMY 469
D+N ++ N++CFLL ISS PNFRP+F++FNR T +G + M+
Sbjct: 436 WDINMLSSMITMTFLLTFGFINLSCFLLRISSTPNFRPTFRYFNRRTTLVGTILSFGVMF 495
Query: 470 VVDNVSASAVISSLCLLFVIIHYFCPPKPWGDVSQSLIYHQVRKYLLRLR--QDNVKYWR 527
VD ++A +L V+I++ CPPK WGDVSQ +IYHQ+RKYLL+ ++N+K+WR
Sbjct: 496 YVDRLNAFISFLIAGILVVVIYFTCPPKNWGDVSQGIIYHQLRKYLLQTNKARENIKFWR 555
Query: 528 PQVLLMVDNPRTSWNLIKFCNHLKKGGLYILGHVTVASNFQSEYQELNKQMRAWVNIRDM 587
PQ+LL+++NP S N+I+FCN LKKG LYILGHV V+ +FQ+ +L KQ R W
Sbjct: 556 PQILLLINNPNRSENVIRFCNSLKKGSLYILGHVIVSDDFQASMDDLRKQQRLWHQFVLD 615
Query: 588 AGIKAFVQIGMGPTLPWGIRNVFMGSGLGGMKPNITVLGFFDLNNYLQKKRPHGVGASSP 647
GIKAFV++ + P WGIR + +GLGG++PNI VL F + N R H + + S
Sbjct: 616 RGIKAFVELTIAPDEVWGIRGLISSAGLGGIRPNIAVLTFINTN-----YRRHRIYSGS- 669
Query: 648 LREDMNFRVTKYKDSISIEMPSHPEFESLPTDECKN--EEKVKLQQWVQVIEDLSLMRSN 705
S S+E S E +D K E + +WVQ++ED+ + +
Sbjct: 670 --------------SFSLENTS----EESESDSKKEFVEHDILPVKWVQILEDMLVGSVD 711
Query: 706 IAVAYGFKNLQLPQKNETRDTKGYIDLYPIQMSATIVNE-NSSGEVTTTNFDTYTLILQL 764
+ V GF L P++ + K YID++PI + + +E N S TNF+TYT++ QL
Sbjct: 712 VMVTNGFDRLNWPKR---KGEKQYIDMFPIHRISGVGSEVNESTPTFATNFETYTMVFQL 768
Query: 765 GAILTTVPDWHRTHQLRVIVFVENERERYDEKKRIDALLSVLRIEAEVLVLSLDQFRV-- 822
IL T DW + +LR+I VE E E E++ + +L RI+A+V+VL L +
Sbjct: 769 SWILHTASDWKQGCRLRLITLVEFENEIEAERESMHQMLETFRIKADVVVLCLAAMNLDA 828
Query: 823 YNTIVKADII---AKKCVDEALKNDDWWRELVDARTRQHSNRKFTTTEPTSIKINGNHLK 879
Y IVK + + ++ LK+D WW+E + R T I+
Sbjct: 829 YRYIVKNEHVRPSKSSELENLLKDDSWWQE-------EKKRRGNTVDSLGPIRFPRRMSG 881
Query: 880 KKYDVSNLQRLGVSLTMASSMPATDMAGNESEYESDYAVGAYESNSTLLSNGDQNQSIHP 939
+ ++ + L S+P + G ++V ++E+ S+ N+S+ P
Sbjct: 882 YNFRSASFDKSAPPL----SVPLSFRLGPHM-----HSVKSFETESSF-----GNRSLSP 927
Query: 940 VRSMKALDNASIRSNRPVFSSKAMPKTKVIEEATGQQPTLVPVIDHTTDIKQNPVLHPIS 999
+ NR +S + + +L+P + ++++ ++
Sbjct: 928 K-----------QENRRTYSDSTI------------ESSLMPNV-----VREDSSSDRLA 959
Query: 1000 PCQSSADLTGSSDELTFNMLPSRVQHLILHDMMTQVXXXXXXXXXXXXXXXXGTHKNELA 1059
P + S ++LTFN L SR Q++I+++++ + THK+
Sbjct: 960 P-KKKIGRDYSKEKLTFNDLSSRSQYIIMNEIVLKHTKNTSVLFTVLPAPLADTHKSFRK 1018
Query: 1060 SLEYVQNIDIWLDGLPPTILINSQSMTVTTAL 1091
S EYV ++ I+++GLPP LI+S+S+T+TTAL
Sbjct: 1019 SEEYVDDLLIFMEGLPPCALIHSKSLTITTAL 1050
>Hs9910386 [E] KOG1288 Amino acid transporters
Length = 914
Score = 384 bits (985), Expect = e-106
Identities = 256/793 (32%), Positives = 414/793 (51%), Gaps = 65/793 (8%)
Query: 55 KLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAIST 114
KL TF GV +PT L++ SI++FLR GF++G G+L +L++++ I T LS+ AI+T
Sbjct: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
Query: 115 NGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLT 174
NG V+GGGAY+MISR LGPE ++++G+VE +L FG +
Sbjct: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPS 155
Query: 175 --QVLPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVLFVK 232
+VLP+G+ + Y ++LL L V +G+ +RA + F L+ S S+ IS + V
Sbjct: 156 GLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVG 215
Query: 233 PFEL--------NGIV-------YTGPSLQILKQNLYPKFTKG-AAGSVLKGYETFNDLF 276
P ++ NG +TG + LK NL + + G+V+ F ++F
Sbjct: 216 PRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMN----FANVF 271
Query: 277 GIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKSLHK 336
+ F GI AGA MS EL+ PS++IP GT+ + TF Y L+ + + L +
Sbjct: 272 AVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQE 331
Query: 337 DVQIIQTVSGFQSIILVGELSTSLFSVIVGMVGAAYVLEAISKDNILPGISIF------- 389
D + +S + ++L+G +T+L + + ++GA+ +L A+++D++ G+ +
Sbjct: 332 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLF-GVILAPAKVVSR 390
Query: 390 GRNPVLCLLFSWFLTQMCLFSD-VNKIAXXXXXXXXXXXXXXNMACFLLEISSAPNFRPS 448
G NP +L+SW L Q+ L + +N +A +++C LE +SAPNFRP+
Sbjct: 391 GGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPT 450
Query: 449 FKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPPKPWGDVSQSLIY 508
F F+ +T LG C++ M+++ +A + + LL ++ P WG VSQ+L++
Sbjct: 451 FSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLF 510
Query: 509 HQVRKYLLRL--RQDNVKYWRPQVLLMVDNPRTSWNLIKFCNHLKKGGLYILGHVTVASN 566
HQVRKYLLRL R+D+VK+WRPQ+LL+V NPR + L++ N LKKGGLY+LGHVT+
Sbjct: 511 HQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKKGGLYVLGHVTLGDL 570
Query: 567 FQSEYQELNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWGIRNVFMGSGLGGMKPNITVLG 626
+ Q AW+++ D A +KAFV + P++ G +++ SGLGGMKPN VLG
Sbjct: 571 DSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTFSPSVRQGAQHLLRISGLGGMKPNTLVLG 630
Query: 627 FFDLNNYLQKKRPHGVGASSPLREDMNFRVTKYKDSISIEMPSHPEFESL--PTDECKNE 684
F+D +P ++ + + S S P +L P +
Sbjct: 631 FYD---------------DAPPQDHFLTDPAFSEPADSTREGSSPALSTLFPPPRAPGSP 675
Query: 685 EKVKLQQWVQVIEDLSLMRSNIAVAYGFKNLQLPQKNETRDTKG-----YIDLYPIQMSA 739
+ Q +V + D M N+ +A + LP + +R + G ++D++P+ +
Sbjct: 676 RALNPQDYVATVADALKMNKNVVLARA--SGALPPERLSRGSGGTSQLHHVDVWPLNL-- 731
Query: 740 TIVNENSSGEVTTTNFDTYTLILQLGAILTTVPDWHRTHQLRVIVFVENERERYDEKKRI 799
+ G V +LQ+ IL VP WH + +LR+ + + + R+
Sbjct: 732 -LRPRGGPGYVDVCGL----FLLQMATILGMVPAWH-SARLRIFLCLGPREAPGAAEGRL 785
Query: 800 DALLSVLRIEAEV 812
ALLS LRI AEV
Sbjct: 786 RALLSQLRIRAEV 798
>CE18193 [E] KOG1288 Amino acid transporters
Length = 952
Score = 376 bits (965), Expect = e-103
Identities = 256/806 (31%), Positives = 404/806 (49%), Gaps = 71/806 (8%)
Query: 56 LGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAISTN 115
L T GVF P L++ SIL+FLR GF++GQ+G L T L L +++ I + T LS+ AIS+N
Sbjct: 83 LSTISGVFAPVALSMFSILLFLRMGFVVGQLGFLMTILQLAMAYAIVMLTVLSLCAISSN 142
Query: 116 GTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLTQ 175
G V GGG YYMISR LGPE + + I G E L+ N G +
Sbjct: 143 GAVEGGGVYYMISRSLGPEFGGAIGVLFFVANVFSCALYISGFTEALMNNIGNGQ----- 197
Query: 176 VLPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVLFVKPFE 235
P+ ++F Y ++ L+ L ++++GS ++ + F L+ + +SV+F E
Sbjct: 198 -FPDSPAWRFVYCVLVSLVLLVLSLLGSALFAKTALITFVLISVCYGTWIVSVIFNGRME 256
Query: 236 L--------------------NGIV----------YTGPSLQILKQNLYPKFTKGAAGSV 265
+ G V YTG S L +N++P++T
Sbjct: 257 VLIPKVNTPAYRVLVNASDPSQGTVEDFNQTLTANYTGWSFHTLGENMFPEYTMDYT--- 313
Query: 266 LKGYETFNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISL 325
+ F +F I F G+ AGA MS EL +PS SIP+GT+ + +T Y + +
Sbjct: 314 TEKPTDFALMFAIIFSGVTGLMAGANMSGELARPSVSIPRGTVQAVFMTLFVYVMTAFLM 373
Query: 326 GCSVPKKSLHKDVQIIQTVSGFQSIILVGELSTSLFSVIVGMVGAAYVLEAISKDNIL-- 383
+ + L D ++ + + IL+G ST+LFS + ++G++ VL +S D +
Sbjct: 374 ATTSSRYLLQNDYTVMMDTNFHRVFILIGIFSTTLFSSMSNLIGSSRVLNRLSHDKLFGC 433
Query: 384 ----PGISIFGRNPVLCLLFSWFLTQMC-LFSDVNKIAXXXXXXXXXXXXXXNMACFLLE 438
I I RNPV+ ++ +W + L +NKIA N+A LE
Sbjct: 434 LLRPAKIEIGDRNPVVSVVITWMCVVLVFLVGAMNKIAKLTSIFFLLSYMGVNVATLALE 493
Query: 439 ISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPPKP 498
++SAPNFRP+FK+F+ T LG + M VVD ++ + L L +++HY P
Sbjct: 494 LTSAPNFRPTFKYFSWQTCALGVVATATMMLVVDASMSALGVVVLMSLIMVLHYQAPSVS 553
Query: 499 WGDVSQSLIYHQVRKYLLRL--RQDNVKYWRPQVLLMVDNPRTSWNLIKFCNHLKKGGLY 556
G +SQ+LIYHQVRKYLL L R+++VKYWRPQ+LL+V P ++ +L+ F N LKK GLY
Sbjct: 554 SGSISQALIYHQVRKYLLLLDVRKEHVKYWRPQILLLVSRPASACSLLDFVNDLKKSGLY 613
Query: 557 ILGHVTVASNFQSEYQE-LNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWGIRNVFMGSGL 615
++GHV S+ + L + W+++ D +KAFV++ M + GI+ + SGL
Sbjct: 614 LVGHVRKGEMDSSQVVDPLQQVFPYWLSLIDYLKLKAFVELTMSNNIRHGIQQLMRLSGL 673
Query: 616 GGMKPNITVLGFFDLNNYLQKKRPHGVG-ASSPLREDMNFRVTKYKDSISIEMPSHPEFE 674
G MKPN V+GF +L P V S L +D+ F +K + +E + ++
Sbjct: 674 GAMKPNTVVIGFHEL-------APSQVTLQESQLLKDLRF--SKIDRAAVVEYFTAGDY- 723
Query: 675 SLPTDECKNEEKVKLQQWVQVIEDLSLMRSNIAVAYGFKNLQLPQ-KNETRDTKGYIDLY 733
+P + N E++ +V V++D+ M N+ VA F L K YID++
Sbjct: 724 -MPKELDGNLERLTPVDYVNVLKDVLHMTKNLCVARHFSKLDKEALARGWNGQKRYIDVW 782
Query: 734 PIQMSATIVNENSSGEVTTTNFDTYTL-ILQLGAILTTVPDWHRTHQLRVIVFVENERER 792
P+ + + T +D +L +LQL IL+ W +LRV + V + ++
Sbjct: 783 PVDL--------QKPQETGLGWDNSSLFLLQLSCILSMSSRWRSYTKLRVFICVNSLQDM 834
Query: 793 YDEKKRIDALLSVLRIEAEVLVLSLD 818
+ ++++ +L LRIE E V+ D
Sbjct: 835 HRRERQLKNMLQTLRIEGESSVVPWD 860
>7298458 [E] KOG1288 Amino acid transporters
Length = 941
Score = 365 bits (938), Expect = e-100
Identities = 252/823 (30%), Positives = 418/823 (50%), Gaps = 84/823 (10%)
Query: 36 TPLQQEQSSKYDLENPHRN--KLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFL 93
TP + ++ +++P R+ LGTF GVF P L++ S L+F+R G+I+G G+ T L
Sbjct: 43 TPQDGDGYVEFGMQDPDRSGRTLGTFAGVFSPVALSMFSALVFIRVGYIVGNAGLYVTLL 102
Query: 94 LLILSFIIDVSTTLSISAISTNGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGM 153
++++ I + T S+ AISTNG + GGG Y+MISR LG E + S M
Sbjct: 103 QFLIAYGILLFTVASVCAISTNGAIEGGGVYFMISRTLGLEFGGSIGTLFFFANVVGSAM 162
Query: 154 NIVGIVEPLLYNFGISEGVLT--QVLPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGN 211
I G E ++ NFG ++ LP+G W++F S+++ L L V ++G+ ++
Sbjct: 163 AISGCTEGIMDNFGPRGHFVSGDSHLPDGDWWRFLTSSMINTLQLLVCLVGAALFAKTSV 222
Query: 212 VLFWLLLASTISIPISVLFVK------PFELNGIV--------YTGPSLQILKQNLYPKF 257
++ + + S LFV P + I+ YTG + L+ NL +
Sbjct: 223 IILATVTVCLFATYFSFLFVGATNNTIPVPGDNILSNTTTFLDYTGLNATTLRDNLGSHY 282
Query: 258 TKGAAGSVLKGYETFNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVC 317
+ + + F+ FG+ F GI AGA MS EL+ PSKSIP GTL + TFV
Sbjct: 283 GRDYTSNGKQ--VDFSTTFGVLFSGVTGIMAGANMSGELKNPSKSIPYGTLSAVAFTFVS 340
Query: 318 YSLVIISLGCSVPKKSLHKDVQIIQTVSGFQSIILVGELSTSLFSVIVGMVGAAYVLEAI 377
Y ++ + C+ P ++ + + V+ + +G L+ + + + ++G++ +LEA+
Sbjct: 341 YIILSFLMSCTTPYFTMQNNYLFLMPVNLWPPFTAIGILTATFSTSLSNLIGSSRILEAL 400
Query: 378 SKDNILPGISIF------GRNPVLCLLFSWFLTQ-MCLFSDVNKIAXXXXXXXXXXXXXX 430
SKD + + F NP+ + SW L + + L N IA
Sbjct: 401 SKDQVFGSLLNFVIHGTWKGNPIAAVAVSWCLVECILLIGSFNIIAQINSVLFMLSYLAT 460
Query: 431 NMACFLLEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVII 490
N+AC +E++ APNFRP FK+F +T +G + +I M+V++ + AS+ I +L + +
Sbjct: 461 NLACLGIELTGAPNFRPLFKFFTWHTCLVGLLGTLIMMFVINFIYASSCIILCLILVIAL 520
Query: 491 HYFCP---PKPWGDVSQSLIYHQVRKYLLRL--RQDNVKYWRPQVLLMVDNPRTSWNLIK 545
H F P WG +SQ+L++HQVRKYLL L R+D+VK+WRPQ+LL+V +PR+ L+
Sbjct: 521 HLFSPATQAAQWGSISQALMFHQVRKYLLMLDPRKDHVKFWRPQILLLVSSPRSCCPLVD 580
Query: 546 FCNHLKKGGLYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWG 605
F N LKK GLYI+GHV + E E N+Q W + D +KAF ++ + ++ G
Sbjct: 581 FVNDLKKSGLYIIGHVKLGDFKGIEDAEDNQQ---WWSFLDHMRVKAFTEVTLSRSIREG 637
Query: 606 IRNVFMGSGLGGMKPNITVLGFFDLNNYLQKKRPHGVGASSPLREDMNFRVTKYKDSISI 665
++++ SG+G MKPN +LGF+D + R SSP + D +F
Sbjct: 638 VQHLIRLSGIGAMKPNTIILGFYD----SEAPRDFFQNGSSPYKTD-DF----------- 681
Query: 666 EMPSHPEFESLPTDECKNEEKVKLQQWVQVIEDLSLMRSNIAVAYGFKNLQLPQKNETRD 725
++ E ++ P + ++ ++Q++VQ++ D M+ N+ + F+ L + ++
Sbjct: 682 ---NNGEIQNFPIRRDGDPKQFQIQEYVQILCDTLRMKKNLCLCRNFQRLDKNFISMSKH 738
Query: 726 TKGYIDLYPIQMSATIVNENSSGEVTTTNFDTYTL-ILQLGAILTTVPDWHRTHQLRVIV 784
K YID++PI I N S FD +L ++QL I+ + LRV +
Sbjct: 739 VK-YIDVWPI----NIFNPTSGDP-----FDMVSLFMMQLAVIMLA-----KWKHLRVRI 783
Query: 785 FV-ENERER----YD---------EKKRIDALLSVLRIEAEVL 813
F+ E ER +D K +++ L LRI A+++
Sbjct: 784 FLCEANDERTVGTFDTQTPQMEIFSKMKLEQSLKELRITADIV 826
>CE19086_2 [P] KOG2083 Na+/K+ symporter
Length = 762
Score = 248 bits (633), Expect = 4e-65
Identities = 181/644 (28%), Positives = 294/644 (45%), Gaps = 71/644 (11%)
Query: 34 QDTPLQQEQSSKYDLENPH------RNKLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMG 87
+D+P+ E ++Y +E H R K G GVF+ LN+ ++++LR ++ GQ G
Sbjct: 7 EDSPVH-ETKNEYRMEKMHAPPSQNRVKFGWIQGVFVRCLLNIFGVMLYLRVSWVSGQAG 65
Query: 88 I-LGTFLLLILSFIIDVSTTLSISAISTNGTVRGGGAYYMISRCLGPEXXXXXXXXXXXX 146
+ LG+ ++L+ S + + T LS AI TNG V+GGGAY++ISR LGPE
Sbjct: 66 VGLGSCIVLLASVVTTI-TALSTCAICTNGDVKGGGAYFLISRSLGPEFGGSIGIIFSIA 124
Query: 147 XXLNSGMNIVGIVEP-----LLYNFGISEGVLTQVLPEGHWYQFGYSTVLLLLCLAVAMI 201
+ + M IVG E + YN G + G W V ++ + + I
Sbjct: 125 NAVGAAMYIVGFAESFRDVLIDYNIG-------TIFDGGLWDVRVIGFVTCVILMGIVFI 177
Query: 202 GSQTVSRAGNVLFWLLLASTISIPISVLFVKPFELNGIVYTGPSLQILKQNLYPKFTKGA 261
GS+ S+ L +LL S + F TG SL L+ N P FT+
Sbjct: 178 GSEFESKMQLGLLVILLVSIANYVFGSFFPPNEIAMNRGATGYSLDTLQSNFMPHFTEN- 236
Query: 262 AGSVLKGYETFNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLV 321
TF +F ++FPA GI AGA +S +L P ++IP GTL +L+T + Y L
Sbjct: 237 --------NTFFSVFSVYFPAATGIMAGANISGDLANPQQAIPLGTLLAILVTTIVYLLT 288
Query: 322 IISLGCSVPKKS-------------------------LHKDVQIIQTVSGFQSIILVGEL 356
+ G +V S L Q+++ S + +I G
Sbjct: 289 VWMTGSTVVAFSNGTEPAVFNNSYFVPPDCTPDCPFGLVSYYQVVEMSSFWGPLITAGIF 348
Query: 357 STSLFSVIVGMVGAAYVLEAISKDNILPGISIF----GRN--PVLCLLFSWFLTQ-MCLF 409
+ +L S + +V A V +A+ KD + P I F G+N P + +FL +
Sbjct: 349 AATLSSALASLVSAPKVFQAVCKDRLFPRIDYFAKTYGKNEEPKRAYVLGFFLAMGIVAI 408
Query: 410 SDVNKIAXXXXXXXXXXXXXXNMACFLLEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMY 469
D+N IA N ACF + +P FRP F ++N + + +GA+ C+ M+
Sbjct: 409 GDLNVIAPIISNFFLGSYALINYACFDQSFADSPGFRPGFTYYNMWISLVGALLCVFVMF 468
Query: 470 VVDNVSASAVISSLCLLFVIIHYFCPPKPWGDVSQSLIYHQVRKYLLRL--RQDNVKYWR 527
++D SA +F+ + + P WG +Q+ Y +++L +++VK +R
Sbjct: 469 IIDWFSALVTFFCFGAIFMYLLHRKPDVNWGSSTQAHSYKNALSAMIKLSTTEEHVKNYR 528
Query: 528 PQVLLMVDNPRTSWNLIKFCNHLKKG-GLYILGHVTVASNFQSEY---QELNKQMRAWVN 583
PQVL++ NP + L+ F N++ KG L + G V Y + L++ + W+
Sbjct: 529 PQVLVLSGNPASRSCLVDFANNITKGSSLLVCGQVVPYEPSDRVYMVMKRLDENINVWLR 588
Query: 584 IRDMAGIKAFVQIGMGPTLPWGIRNVFMGSGLGGMKPNITVLGF 627
R +KAF + G +++ +G+ MKPNI ++GF
Sbjct: 589 KRH---LKAFYRAVANSNFRKGAQSLIQLTGIAKMKPNIVLMGF 629
>7294587 [P] KOG2083 Na+/K+ symporter
Length = 1171
Score = 244 bits (624), Expect = 4e-64
Identities = 171/613 (27%), Positives = 288/613 (46%), Gaps = 54/613 (8%)
Query: 55 KLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAIST 114
K G GV + LN+ +++FLR +++GQ G++ F+L++ + + T LS+SAIST
Sbjct: 211 KFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSMSAIST 270
Query: 115 NGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLL-----YNFGIS 169
NG ++GGG YYMISR LGPE + M +VG E +L + + I
Sbjct: 271 NGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEII 330
Query: 170 EGVLTQVLPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVL 229
+G + V G T+LLLL + V + + ++ G +L LL+A + S +
Sbjct: 331 DGGVQDV------RIIGCITILLLLIIVVVGMEWEAKAQIG-LLIILLVAIGDFVIGSFI 383
Query: 230 FVKPFELNGIVYTGPSLQILKQNLYPKFTKGAAGSVLKGYETFNDLFGIFFPATAGIFAG 289
K + G + + K NL+ + G F +F IFFPA GI AG
Sbjct: 384 GPKSDAEMAKGFLGYNATLFKNNLFADYRPEKGGI----QHDFFSVFAIFFPAATGILAG 439
Query: 290 AGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKS---------------- 333
A +S +L+ P KSIPKGT+ +++T Y ++++ G +V + +
Sbjct: 440 ANISGDLKDPQKSIPKGTILAIVITTGTYLIMVLQCGATVARDATGNLSDVVNGTFAFLD 499
Query: 334 ---------LHKDVQIIQTVSGFQSIILVGELSTSLFSVIVGMVGAAYVLEAISKDNILP 384
L Q+I+ VS F +I G + +L S + +V A V +A+ KD + P
Sbjct: 500 CQPGECNYGLQNSFQVIELVSAFGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYP 559
Query: 385 GISIF----GRN--PVLCLLFSWFLT-QMCLFSDVNKIAXXXXXXXXXXXXXXNMACFLL 437
I F G+N PV + ++ + L ++N IA N + F
Sbjct: 560 KIVWFAKGYGKNNEPVRGYVLTFIIACAFILIGELNLIAPLISNFFLAAYMLINFSTFHA 619
Query: 438 EISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPPK 497
++ +RP+FK++N + + LGA+ C+ M+++ +A +++ L++I+ Y P
Sbjct: 620 SLAKPVGWRPTFKYYNMWLSLLGAILCVAVMFLISWATALITFAAVLALYLIVAYRKPDV 679
Query: 498 PWGDVSQSLIYHQVRKYLLRLR--QDNVKYWRPQVLLMVDNPRTSWNLIKFCNHLKKG-G 554
WG +Q+ Y + +L +++VK +RPQ+L++ P T L+ L K
Sbjct: 680 NWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILVLSGLPNTRPVLVDLAYMLTKNLS 739
Query: 555 LYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWGIRNVFMGSG 614
L + GHV S+ Q L ++ W + G A V G G R + +G
Sbjct: 740 LLVCGHVLKGSSSQKYRTYLQERAGNWFRKHRVKGFYALVD---GEDFESGTRALMQATG 796
Query: 615 LGGMKPNITVLGF 627
+G +KPNI ++G+
Sbjct: 797 IGKLKPNIILMGY 809
>Hs4506975 [P] KOG2083 Na+/K+ symporter
Length = 1212
Score = 242 bits (618), Expect = 2e-63
Identities = 182/629 (28%), Positives = 295/629 (45%), Gaps = 62/629 (9%)
Query: 46 YDLENPHRNKLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVST 105
Y E+ K G GV + LN+ +++F+R +I+GQ GI + L+++++ ++ T
Sbjct: 275 YTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTIT 334
Query: 106 TLSISAISTNGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYN 165
LS SAI+TNG VRGGGAYY+ISR LGPE + M +VG E ++
Sbjct: 335 GLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVEL 394
Query: 166 FGISEGVLTQVLPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIP 225
+ E + + G TV++LL ++VA G + ++A VL +LL +
Sbjct: 395 --LKEHSILMIDEINDIRIIGAITVVILLGISVA--GMEWEAKAQIVLLVILLLAIGDFV 450
Query: 226 ISVLFVKPFELNGIVYTGPSLQILKQNLYPKFTKGAAGSVLKGYETFNDLFGIFFPATAG 285
I F+ + G +I +N P F + ETF +F IFFPA G
Sbjct: 451 IGT-FIPLESKKPKGFFGYKSEIFNENFGPDF---------REEETFFSVFAIFFPAATG 500
Query: 286 IFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKS------------ 333
I AGA +S +L P +IPKGTL +L+T + Y + +S+G V + +
Sbjct: 501 ILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTEL 560
Query: 334 -------------------------LHKDVQIIQTVSGFQSIILVGELSTSLFSVIVGMV 368
L + Q++ VSGF +I G S +L S + +V
Sbjct: 561 TNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLV 620
Query: 369 GAAYVLEAISKDNILPGISIF----GRN--PVLCLLFSWFLT-QMCLFSDVNKIAXXXXX 421
A + +A+ KDNI P +F G+N P+ + ++ + L +++N IA
Sbjct: 621 SAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISN 680
Query: 422 XXXXXXXXXNMACFLLEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVIS 481
N + F ++ +P +RP+FK++N + + LGA+ C I M+V++ +A
Sbjct: 681 FFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYV 740
Query: 482 SLCLLFVIIHYFCPPKPWGDVSQSLIYHQVRKYLLRLR--QDNVKYWRPQVLLMVDNPRT 539
+ L++ + Y P WG +Q+L Y ++ +RL +D+VK +RPQ L+M P +
Sbjct: 741 IVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNS 800
Query: 540 SWNLIKFCNHLKKG-GLYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAGIKAFVQIGM 598
L+ + K GL I GHV + Q+ +E++ + +KAF
Sbjct: 801 RPALLHLVHDFTKNVGLMICGHVHMGPRRQA-MKEMSIDQAKYQRWLIKNKMKAFYAPVH 859
Query: 599 GPTLPWGIRNVFMGSGLGGMKPNITVLGF 627
L G + + +GLG MKPN VLGF
Sbjct: 860 ADDLREGAQYLMQAAGLGRMKPNTLVLGF 888
>Hs4557849 [P] KOG2083 Na+/K+ symporter
Length = 1099
Score = 234 bits (596), Expect = 7e-61
Identities = 182/625 (29%), Positives = 291/625 (46%), Gaps = 71/625 (11%)
Query: 55 KLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAIST 114
K G GV + LN+ +++F+R +I+G+ GI +++ LS I+ T +S SAI+T
Sbjct: 176 KFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLSTIVTTITGMSTSAIAT 235
Query: 115 NGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLT 174
NG VRGGGAYY+ISR LGPE + M +VG E ++ S+ ++
Sbjct: 236 NGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMM- 294
Query: 175 QVLPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVLFVKPF 234
V P G TV++LL ++VA G + ++A +L +LL + + I +
Sbjct: 295 -VDPTNDIRIIGSITVVILLGISVA--GMEWEAKAQVILLVILLIAIANFFIGTVIPSNN 351
Query: 235 ELNGIVYTGPSLQILKQNLYPKFTKGAAGSVLKGYETFNDLFGIFFPATAGIFAGAGMSS 294
E + I +N P+FTKG E F +F IFFPA GI AGA +S
Sbjct: 352 EKKSRGFFNYQASIFAENFGPRFTKG---------EGFFSVFAIFFPAATGILAGANISG 402
Query: 295 ELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKS--------------------- 333
+L P +IP+GT+ + +T V Y V I +G V + +
Sbjct: 403 DLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACG 462
Query: 334 ----------------LHKDVQIIQTVSGFQSIILVGELSTSLFSVIVGMVGAAYVLEAI 377
L + Q++ VSGF +I G S +L S + +V A V +A+
Sbjct: 463 LGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQAL 522
Query: 378 SKDNILPGISIF----GRN--PVLCLLFSWFLTQ-MCLFSDVNKIAXXXXXXXXXXXXXX 430
KDNI + F G+N P+ + ++ + L +++N IA
Sbjct: 523 CKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALI 582
Query: 431 NMACFLLEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVII 490
N +CF + +P +RP++ +N + + GA+ C M+V++ +AVI+ + F+ +
Sbjct: 583 NFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVIN--WWAAVITYVIEFFLYV 640
Query: 491 HYFC--PPKPWGDVSQSLIYHQVRKYLLRLR--QDNVKYWRPQVLLMVDNPRTSWNLIKF 546
+ C P WG +Q+L Y L L +D+VK +RPQ +++ P T L+
Sbjct: 641 YVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDI 700
Query: 547 CN-HLKKGGLYILGHVTVASNFQSEYQELNKQM---RAWVNIRDMAGIKAFVQIGMGPTL 602
+ K GL I V V + +E+N M +AW+ I++ IKAF
Sbjct: 701 THAFTKNSGLCICCEVFVGPR-KLCVKEMNSGMAKKQAWL-IKNK--IKAFYAAVAADCF 756
Query: 603 PWGIRNVFMGSGLGGMKPNITVLGF 627
G+R++ SGLG MKPN V+G+
Sbjct: 757 RDGVRSLLQASGLGRMKPNTLVIGY 781
>Hs4506977 [P] KOG2083 Na+/K+ symporter
Length = 1030
Score = 230 bits (587), Expect = 8e-60
Identities = 181/638 (28%), Positives = 291/638 (45%), Gaps = 73/638 (11%)
Query: 43 SSKYDLENPHRNKLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIID 102
SS+ + E P R G GV I LN+ ++++LR +I Q GI+ T+++++LS +
Sbjct: 125 SSEKNPEEPVR--FGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVT 182
Query: 103 VSTTLSISAISTNGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVE-- 160
T LSISAISTNG V+ GG Y++ISR LGPE + M+ VG E
Sbjct: 183 SITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETV 242
Query: 161 -PLLYNFGISEGVLTQVLPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLA 219
LL +G V P G +V +L LA+++ G + S+A + F +++
Sbjct: 243 RDLLQEYG-----APIVDPINDIRIIGVVSVTVL--LAISLAGMEWESKAQVLFFLVIMV 295
Query: 220 STISIPISVLFVKPFELNGIVYTGPSLQILKQNLYPKFTKGAAGSVLKGYETFNDLFGIF 279
S + + L + + I QNL P + +G G TF +F IF
Sbjct: 296 SFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDW-RGPDG-------TFFGMFSIF 347
Query: 280 FPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKS------ 333
FP+ GI AGA +S +L+ P+ +IPKGTL + T + Y + ++G V + +
Sbjct: 348 FPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLND 407
Query: 334 --------------------------------LHKDVQIIQTVSGFQSIILVGELSTSLF 361
L Q + VSGF +I G +L
Sbjct: 408 TVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLS 467
Query: 362 SVIVGMVGAAYVLEAISKDNILPGISIFG------RNPVLCLLFSWFL-TQMCLFSDVNK 414
S + +V AA V + + +D + P I FG + PV L ++ + + +++N
Sbjct: 468 SALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNT 527
Query: 415 IAXXXXXXXXXXXXXXNMACFLLEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNV 474
IA N +CF I+++P +RPSF+++N++ A GA+ ++ M+++
Sbjct: 528 IAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWW 587
Query: 475 SASAVISSLCLLFVIIHYFCPPKPWGDVSQSLIYHQVRKYLLRLR--QDNVKYWRPQVLL 532
+A I + L + + Y P WG Q+ Y+ Y + L +D++K +RPQ L+
Sbjct: 588 AALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLV 647
Query: 533 MVDNPRTSWNLIKFCNHLKKG-GLYILGHVTVASNFQ--SEYQELNKQMRAWVNIRDMAG 589
+ P L+ F + L I GHV + + Q E Q + W+N R
Sbjct: 648 LTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRK--- 704
Query: 590 IKAFVQIGMGPTLPWGIRNVFMGSGLGGMKPNITVLGF 627
IKAF + L G++ + +GLG MKPNI V+GF
Sbjct: 705 IKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGF 742
>At1g30450_1 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transporters
Length = 965
Score = 226 bits (576), Expect = 2e-58
Identities = 175/614 (28%), Positives = 284/614 (45%), Gaps = 43/614 (7%)
Query: 51 PHRNKLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSIS 110
P K+GT GVF+P N+L I+ ++RF +I+G GI +L+ L + TT+S+S
Sbjct: 127 PPALKMGTMMGVFVPCLQNILGIIYYIRFTWIVGMAGIGQGLVLVFLCGLCTFLTTISLS 186
Query: 111 AISTNGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNF---G 167
AI+TNG ++GGG YY+I R LGPE + + ++G VE L F G
Sbjct: 187 AIATNGAMKGGGPYYLIGRALGPEVGISIGLCFFLGNAVAGALYVLGAVETFLKAFPAAG 246
Query: 168 ISEGVLTQV----------LPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLL 217
I +T+V P H Q V +LLC + G + ++R +
Sbjct: 247 IFRETITKVNGTAVSESIQSPNSHDLQVYGIVVTILLCF-IVFGGVKMINRVAPAFLVPV 305
Query: 218 LASTISIPISVLFVKPFEL-NGIVYTGPSLQILKQNLYPKF----TKGAAGSVLKGYETF 272
L S I I + K + NGI TG L+ K N + G Y +F
Sbjct: 306 LLSIFCIFIGIFLAKTDDPDNGI--TGLRLKSFKDNWGSAYQMTNDAGIPDPTGGTYWSF 363
Query: 273 NDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKK 332
N+L G+FFPA GI AG+ S+ L+ KSIP GTL L T Y + ++ G +
Sbjct: 364 NELVGLFFPAVTGIMAGSNRSASLKDTQKSIPVGTLAATLTTTSLYLISVLFFGAVATRD 423
Query: 333 SLHKDVQIIQTVS-GFQSIILVGELSTSLFSVIVGMVGAAYVLEAISKDNILPGISIF-- 389
L D + T++ F +I+ VG + ++L + + + GA +L AI+ D+ILP ++ F
Sbjct: 424 KLLTDRLLTATIAWPFPAIVHVGIILSTLGAALQSLTGAPRLLAAIANDDILPILNYFKV 483
Query: 390 --GRNPVLCLLFSWFLTQMC-LFSDVNKIAXXXXXXXXXXXXXXNMACFLLEISSAPNFR 446
P + LF+ F+ C + +++ I N++CFLL++ AP++R
Sbjct: 484 ADTSEPHIATLFTAFICIGCVVIGNLDLITPTVTMFYLLCYSGVNLSCFLLDLLDAPSWR 543
Query: 447 PSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPPKPWGDVSQSL 506
P +K+ + +F+GA CI+ M+++ I+ L++ + WGD +S
Sbjct: 544 PRWKYHHWSLSFVGASLCIVIMFLISWSFTVVAIALASLIYKYVGLKGKAGDWGDGFKSA 603
Query: 507 IYHQVRKYLLRLRQDNV--KYWRPQVLL-------MVDNPRTSWNLIKFCNHLKKGGLYI 557
+ + L L + V K W P L+ + +N L F N +KK G +
Sbjct: 604 YFQLALRSLRSLGANQVHPKNWYPIPLVFCRPWGQLPENVPCHPKLADFANCMKKKGRGM 663
Query: 558 LGHVTVAS----NFQSEYQELNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWGIRNVFMGS 613
V++ E +E KQ+ ++ + G+ +I + P + G R +
Sbjct: 664 SIFVSILDGDYYECAEEAKEACKQLATYIEYKRCEGV---AEIVVAPNMTEGFRGIIQTM 720
Query: 614 GLGGMKPNITVLGF 627
GLG +KPNI V+ +
Sbjct: 721 GLGNLKPNIVVMRY 734
>7296739 [P] KOG2083 Na+/K+ symporter
Length = 954
Score = 217 bits (552), Expect = 9e-56
Identities = 156/614 (25%), Positives = 285/614 (46%), Gaps = 53/614 (8%)
Query: 55 KLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAIST 114
KLG GV IP LN+ +++FLR +++ + GIL + +++ +S ++ V TTLS+SAIST
Sbjct: 21 KLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAIST 80
Query: 115 NGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLT 174
NG V+GGG Y++ISR LGPE +++ MN +G E L N + L
Sbjct: 81 NGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIGFCESL--NVLLKNNDL- 137
Query: 175 QVLPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVLFVKPF 234
+++ G ++ +L+ + + +G + ++A N L ++ + + I
Sbjct: 138 KIVDNGINDIRIVGSITVLVLILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQG 197
Query: 235 ELNGIV--YTGPSLQILKQNLYPKFTKGAAGSVLKGYETFNDLFGIFFPATAGIFAGAGM 292
I + G S LK+N + + F +F IFFP+ GI AGA +
Sbjct: 198 NEEQISRGFVGFSWATLKENFGSDYRYAEGVN-----HDFFSVFAIFFPSVTGIQAGANI 252
Query: 293 SSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKS------------------- 333
+L+ +IPKGT W LL++ Y+L ++ G + + +
Sbjct: 253 CGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPC 312
Query: 334 ---------LHKDVQIIQTVSGFQSIILVGELSTSLFSVIVGMVGAAYVLEAISKDNILP 384
L +++Q +S + +I G + +L + + ++ +++A+ D I P
Sbjct: 313 MATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYP 372
Query: 385 GISIFGR------NPVLCLLFSWFLTQ-MCLFSDVNKIAXXXXXXXXXXXXXXNMACFLL 437
G+ F + P + ++F+T L ++N IA N F
Sbjct: 373 GLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINFCTFHA 432
Query: 438 EISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPPK 497
+RP+FK++N + + G C+ M++++ V+A + L++++ Y P
Sbjct: 433 AFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFALYLVVMYRKPEA 492
Query: 498 PWGDVSQSLIYHQVRKYLLRLR--QDNVKYWRPQVLLMVDNPRTSWNLIKFCNHLKKGG- 554
WG +Q+ Y + RL+ D+VK + PQVL++ +P+T L+ F L K
Sbjct: 493 NWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSGDPKTRPPLVDFGYLLTKNNS 552
Query: 555 -LYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWGIRNVFMGS 613
+++ + V +++ Q L K + +++ R IKAF + G +L GI + +
Sbjct: 553 LMFVANIIPVRVGYKNR-QHLVKDGQKYLDARK---IKAFYNVIDGFSLEDGINALTKST 608
Query: 614 GLGGMKPNITVLGF 627
G G M PNI ++G+
Sbjct: 609 GFGKMSPNIVLVGY 622
>CE25033 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transporters
Length = 981
Score = 170 bits (431), Expect = 1e-41
Identities = 171/684 (25%), Positives = 287/684 (41%), Gaps = 122/684 (17%)
Query: 56 LGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAISTN 115
+GT GVF+P N+ +L F+R +IIG G+ F +++ + T++S+SAI+TN
Sbjct: 1 MGTIMGVFLPCLQNIFGVLFFIRLAWIIGTAGVFQAFFVVLTCVSVTFLTSISLSAIATN 60
Query: 116 GTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLL------------ 163
G V GG YYMISR LGPE + + M I G +E LL
Sbjct: 61 GVVPSGGPYYMISRNLGPELGGAVGILFYLGTTIAASMYITGAIEILLLYIYPQAKLFDD 120
Query: 164 --YNFGISEGVLTQVLPEGHWYQFGYS---------TVLLLLCLAVAMIGSQTVSRAGNV 212
+NF + VL +L G G ++++LC+ A++G V G+
Sbjct: 121 IYHNFRVLGTVLLLIL--GLIVMAGVKFVNRCALPLVIVVILCILSAILGV-FVRYDGSD 177
Query: 213 LFWLLLASTISIPISVLF----------------------------------VKPFELNG 238
+ + +S F +K ++ +G
Sbjct: 178 SLKFCMVGDRPVDLSTYFEKTQVQPNCTADGLQDLFCSTNGTCDHYYDRMKNIKVWKSSG 237
Query: 239 I-------VYTGPSLQILKQNLYPKFTKGAAGSVL---------------------KGYE 270
+ G + + NL+PK+ + AG VL +
Sbjct: 238 MPAIREERAIKGIASGVFFDNLWPKYLR--AGEVLSKDRKDKGDLNRGGHPSYIYAESVT 295
Query: 271 TFNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVP 330
F L G+FFP+ GI AG+ S LR +KSIP GTL + Y L ++ G SV
Sbjct: 296 NFMILVGVFFPSATGIMAGSNRSGNLRDAAKSIPLGTLAAQNFSSFIYLLGVVLFGASVS 355
Query: 331 KKSLHKDV-------QIIQTVS-GFQSIILVGELSTSLFSVIVGMVGAAYVLEAISKDNI 382
+ + II +S F +IL G ++ + + + GA +L+AI+ D++
Sbjct: 356 EMFIRDKYGRSAMGKLIISEISWPFPQVILFGCFMSTAGAGMQSLTGAPRLLQAIAADDV 415
Query: 383 LPGISIFGR-----NPVLCLLFSWFLTQM-CLFSDVNKIAXXXXXXXXXXXXXXNMACFL 436
LP + F + P+ +L + + + L + + I N AC L
Sbjct: 416 LPFLKPFRKMDSRGEPIRAILLTLAICECGILIAVIENITALITQFFLMCYLGVNAACAL 475
Query: 437 LEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPP 496
+ +P +RP F++F+ + +GA+ C+ M++ A I ++ I Y
Sbjct: 476 QSLLKSPGWRPGFRYFHWSLSMIGAILCVAVMFISAWHFALFAIIIGAGVYKYIEYAGAE 535
Query: 497 KPWGDVSQSLIYHQVRKYLLRL--RQDNVKYWRPQVLLM---VDNPRTSWNLIKFCNHLK 551
K WGD + L R LL L + + + WRPQ+L++ V++ T+ ++ F + LK
Sbjct: 536 KEWGDGLRGLGLSAARFALLNLDDKPQHSRNWRPQLLVLAPDVESANTN-GILSFVSQLK 594
Query: 552 KG-GLYILGHVTVASNFQSEY---QELNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWGI- 606
G GL ++ H + + Y Q + ++++A V IK F + + + GI
Sbjct: 595 AGKGLTLVAH-CMEGEYADNYLKAQAVQEKLKAVVKKNK---IKGFCDVLVTSNVIEGIS 650
Query: 607 ---RNVFMGSGLGGMKPNITVLGF 627
+ + SGLGGM+ N VL +
Sbjct: 651 CLVQVIDPTSGLGGMRHNTVVLSW 674
>Hs4827006 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transporters
Length = 1085
Score = 152 bits (384), Expect = 3e-36
Identities = 110/382 (28%), Positives = 183/382 (47%), Gaps = 30/382 (7%)
Query: 271 TFNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGC--- 327
+F L GIFFP+ GI AG+ S +LR KSIP GT+ ++ T + Y ++ G
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 328 SVPKKSLHKDVQIIQTVSGFQS-----IILVGELSTSLFSVIVGMVGAAYVLEAISKDNI 382
V + + D V G + +I++G ++ + + + GA +L+AI+KDNI
Sbjct: 479 GVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 538
Query: 383 LPGISIFGRN-----PVLCLLFSWFLTQM-CLFSDVNKIAXXXXXXXXXXXXXXNMACFL 436
+P + +FG P LL + + ++ L + ++ +A N+AC +
Sbjct: 539 IPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAV 598
Query: 437 LEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPP 496
+ PN+RP FK+++ +FLG C+ M+V A + +++ I Y
Sbjct: 599 QTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAE 658
Query: 497 KPWGDVSQSLIYHQVRKYLLRLRQ--DNVKYWRPQVLLM--------VDNPRTSWNLIKF 546
K WGD + L R LLRL + + K WRPQ+L++ V PR L+ F
Sbjct: 659 KEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPR----LLTF 714
Query: 547 CNHLKKG-GLYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWG 605
+ LK G GL I+G V + +F Y E + N+ ++ +K F Q+ + + G
Sbjct: 715 ASQLKAGKGLTIVGSV-IQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREG 773
Query: 606 IRNVFMGSGLGGMKPNITVLGF 627
+ ++ GLGGM+ N VLG+
Sbjct: 774 LAHLIQSCGLGGMRHNSVVLGW 795
Score = 84.0 bits (206), Expect = 1e-15
Identities = 52/184 (28%), Positives = 88/184 (47%), Gaps = 25/184 (13%)
Query: 56 LGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAISTN 115
+GT GV++P N+ +++FLR +++G G+L L++++ + T +S+SAI+TN
Sbjct: 118 MGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATN 177
Query: 116 GTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLTQ 175
G V GG+Y+MISR LGPE + M I+G +E L LT
Sbjct: 178 GVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEIL----------LTY 227
Query: 176 VLPEGH-WYQFG--------------YSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLAS 220
+ P +Y G Y T+ L V +G + V++ ++ ++ S
Sbjct: 228 IAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIIS 287
Query: 221 TISI 224
+SI
Sbjct: 288 ILSI 291
>Hs4826780 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transporters
Length = 1099
Score = 152 bits (383), Expect = 4e-36
Identities = 110/382 (28%), Positives = 184/382 (47%), Gaps = 30/382 (7%)
Query: 271 TFNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVP 330
+F L GIFFP+ GI AG+ S +L+ KSIP GT+ +L T Y ++ G +
Sbjct: 433 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 492
Query: 331 KKSLH-------KDVQIIQTVSGFQS-IILVGELSTSLFSVIVGMVGAAYVLEAISKDNI 382
L K ++ T+S +I++G ++ + + + GA +L+AI+KDNI
Sbjct: 493 GVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 552
Query: 383 LPGISIFGRN-----PVLCLLFSWFLTQM-CLFSDVNKIAXXXXXXXXXXXXXXNMACFL 436
+P + +FG + P LL + + ++ L + ++ +A N+AC L
Sbjct: 553 IPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACAL 612
Query: 437 LEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPP 496
+ PN+RP F++++ +F+G C+ M++ A + +++ I Y
Sbjct: 613 QTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAE 672
Query: 497 KPWGDVSQSLIYHQVRKYLLRLRQ--DNVKYWRPQVLLM--------VDNPRTSWNLIKF 546
K WGD + L R LLRL + + K WRPQ+L++ V +PR L+ F
Sbjct: 673 KEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPR----LLTF 728
Query: 547 CNHLKKG-GLYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWG 605
+ LK G GL I+G V + NF Y E + ++ + +K F Q+ + L G
Sbjct: 729 ASQLKAGKGLTIVGSV-IVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREG 787
Query: 606 IRNVFMGSGLGGMKPNITVLGF 627
I ++ GLGGMK N V+G+
Sbjct: 788 ISHLIQSCGLGGMKHNTVVMGW 809
Score = 88.2 bits (217), Expect = 6e-17
Identities = 57/212 (26%), Positives = 102/212 (47%), Gaps = 6/212 (2%)
Query: 19 SPLLKRRSSLTYFKYQDTPLQQEQSSKYDLENPHRN-KLGTFDGVFIPTTLNVLSILMFL 77
S LL R ++ T ++ ++ + P + ++GTF GV++P N+ +++FL
Sbjct: 96 SSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFL 155
Query: 78 RFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAISTNGTVRGGGAYYMISRCLGPEXXX 137
R +++G G+L F ++++ + T +S+SAI+TNG V GG+Y+MISR LGPE
Sbjct: 156 RLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGG 215
Query: 138 XXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVL--TQVLPEGHWYQFG---YSTVLL 192
+ M I+G +E L + L E Y T L
Sbjct: 216 AVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFL 275
Query: 193 LLCLAVAMIGSQTVSRAGNVLFWLLLASTISI 224
+L + V IG + V++ ++ ++ S ++I
Sbjct: 276 VLMVLVVFIGVRYVNKFASLFLACVIVSILAI 307
>7290145 [P] KOG2083 Na+/K+ symporter
Length = 712
Score = 147 bits (372), Expect = 7e-35
Identities = 97/335 (28%), Positives = 161/335 (47%), Gaps = 22/335 (6%)
Query: 57 GTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAISTNG 116
GT+DGVF +NV +++FLR G+I+ Q GIL L++ + +I + + LS I
Sbjct: 93 GTWDGVFTSCLINVFGVIVFLRSGWIVAQAGILNAVLIIFCTVVIALVSVLSAIGICERC 152
Query: 117 TVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLTQV 176
V GG Y++I+ LG + +N++G E + G+ EG
Sbjct: 153 RVESGGVYFLIAHTLGSRFGGALGLLYCFGQAVGCALNVMGFGESMAGLVGL-EG----- 206
Query: 177 LPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVLFVKPFEL 236
W G++T +LL + + G + V + +L +LL S + + E
Sbjct: 207 ---SKWAIRGFATAAVLLLGCINVAGVKWVIKLQFILLMILLISALDFMVGSF---TSEA 260
Query: 237 NGIVYTGPSLQILKQNLYPKFTKGAAGSVLKGYETFNDLFGIFFPATAGIFAGAGMSSEL 296
+G + G + +NL+PK+ G Y F +FG+FFP G+ +G MS +L
Sbjct: 261 SG-GFNGWASGNFVENLWPKYDDG--------YSWFR-VFGVFFPTVTGVLSGINMSGDL 310
Query: 297 RKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKSLHKDVQIIQTVSGFQSIILVGEL 356
R PS IP GTL + Y + ++ LG + + L+ D I VS ++L G
Sbjct: 311 RAPSTDIPNGTLAAFGTSTFLYLVFVLFLGATCQRSFLYTDYMISVKVSAVHFLLLAGIY 370
Query: 357 STSLFSVIVGMVGAAYVLEAISKDNILPGISIFGR 391
+S+ S + M G VL++I+K++++PGI I G+
Sbjct: 371 VSSMSSCLGAMYGTPRVLQSIAKESVIPGIDILGK 405
>Hs11968148 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transporters
Length = 1116
Score = 138 bits (348), Expect = 4e-32
Identities = 101/387 (26%), Positives = 180/387 (46%), Gaps = 24/387 (6%)
Query: 272 FNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPK 331
F L GI+FP+ GI AG+ S +LR KSIP GT+ + T Y ++ G +
Sbjct: 400 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 459
Query: 332 KSLHKDV------QIIQTVSGFQS--IILVGELSTSLFSVIVGMVGAAYVLEAISKDNIL 383
L ++ + S +I++G ++ + + + GA +L+AIS+D I+
Sbjct: 460 VVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIV 519
Query: 384 PGISIFGRN-----PVLCLLFSWFLTQM-CLFSDVNKIAXXXXXXXXXXXXXXNMACFLL 437
P + +FG P LL + + ++ L + ++++A N+AC +
Sbjct: 520 PFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQ 579
Query: 438 EISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPPK 497
+ PN+RP F++++ +FLG C+ M++ A + L++ I Y K
Sbjct: 580 TLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEK 639
Query: 498 PWGDVSQSLIYHQVRKYLLRLRQ--DNVKYWRPQVLLMV----DNPRTSWNLIKFCNHLK 551
WGD + L R LLRL + + K WRPQ+L++V D L+ + LK
Sbjct: 640 EWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLK 699
Query: 552 KG-GLYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAGIKAFVQIGMGPTLPWGIRNVF 610
G GL I+G V + F + + + + + + +K F Q+ + L G+ ++
Sbjct: 700 AGKGLTIVGSV-LEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLI 758
Query: 611 MGSGLGGMKPNITVLGFFDLNNYLQKK 637
GLGG++ N ++G+ N+ QK+
Sbjct: 759 QSGGLGGLQHNTVLVGW--PRNWRQKE 783
Score = 86.3 bits (212), Expect = 2e-16
Identities = 52/180 (28%), Positives = 87/180 (47%), Gaps = 5/180 (2%)
Query: 55 KLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAIST 114
++GTF GV++P N+ +++FLR +++G GI+ +F ++ + + T +S+SAI+T
Sbjct: 96 RMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIAT 155
Query: 115 NGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLT 174
NG V GG+YYMISR LGPE M I+G +E LL + +
Sbjct: 156 NGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFK 215
Query: 175 QVLPEGHWYQF-----GYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVL 229
G Y T +L V +G + V++ V ++ S ++I V+
Sbjct: 216 AEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVI 275
>Hs5730043 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transporters
Length = 1083
Score = 137 bits (344), Expect = 1e-31
Identities = 105/385 (27%), Positives = 182/385 (47%), Gaps = 36/385 (9%)
Query: 271 TFNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVP 330
+F L GI+FP+ GI AG+ S +L+ KSIP GT+ ++ T Y I+ G +
Sbjct: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
Query: 331 K--------KSLHKDVQIIQTVSGFQSIILVGELSTSLFSVIVGMVGAAYVLEAISKDNI 382
++L ++ I +I++G ++ + + + GA +L+AI++D I
Sbjct: 479 GVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQTLTGAPRLLQAIARDGI 538
Query: 383 LPGISIFGRN-----PVLCLLFSWFLTQM-CLFSDVNKIAXXXXXXXXXXXXXXNMACFL 436
+P + +FG P LL + + + L + ++ +A N+AC +
Sbjct: 539 VPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAV 598
Query: 437 LEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPP 496
+ PN+RP FK+++ +FLG C+ M++ A + + ++ I Y
Sbjct: 599 QTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAE 658
Query: 497 KPWGDVSQSLIYHQVRKYLLRLRQ--DNVKYWRPQVLLM--------VDNPRTSWNLIKF 546
K WGD + L + R LLR+ + K WRPQVL+M V +PR L+ F
Sbjct: 659 KEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPR----LLSF 714
Query: 547 CNHLKKG-GLYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAG---IKAFVQIGMGPTL 602
+ LK G GL I+G V + + ++ E RA NIR + K F Q+ + +L
Sbjct: 715 TSQLKAGKGLTIVGSV-LEGTYLDKHME---AQRAEENIRSLMSTEKTKGFCQLVVSSSL 770
Query: 603 PWGIRNVFMGSGLGGMKPNITVLGF 627
G+ ++ +GLGG+K N ++ +
Sbjct: 771 RDGMSHLIQSAGLGGLKHNTVLMAW 795
Score = 94.0 bits (232), Expect = 1e-18
Identities = 58/196 (29%), Positives = 96/196 (48%), Gaps = 8/196 (4%)
Query: 39 QQEQSSKYDLENPHRNKLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILS 98
+ E+S + + + P ++GTF GV++P N+L +++FLR +I+G G+L +FL++ +
Sbjct: 104 EDEESRRREAKAP---RMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMC 160
Query: 99 FIIDVSTTLSISAISTNGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGI 158
+ T +S+SAI+TNG V GG+YYMISR LGPE M I+G
Sbjct: 161 CTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGT 220
Query: 159 VEPLLYNFGISEGVLTQVLPEGHWYQF-----GYSTVLLLLCLAVAMIGSQTVSRAGNVL 213
+E L + G Y T L+L V +G + V++ V
Sbjct: 221 IEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVF 280
Query: 214 FWLLLASTISIPISVL 229
++ S ++I V+
Sbjct: 281 LACVVLSILAIYAGVI 296
>CE04838 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transporters
Length = 1003
Score = 118 bits (296), Expect = 4e-26
Identities = 101/386 (26%), Positives = 180/386 (46%), Gaps = 31/386 (8%)
Query: 271 TFNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLT-FVCYSLVIISLGCSV 329
+F L I+FPA GIF GA MS +L+ P SIP GT+ L T FV +SL I G
Sbjct: 328 SFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAANLTTSFVYFSLAFIFGGAID 387
Query: 330 PKKSLHKDVQII--QTVSGFQS-----IILVGELSTSLFSVIVGMVGAAYVLEAISKDNI 382
K+ Q + Q V S ++L+G ++ + + + A +L+AI+KD +
Sbjct: 388 NAVLRDKNGQSVGGQMVVALLSWPSPWVLLIGSFLSTFGAALQCLCSAPRLLQAIAKDEV 447
Query: 383 LPGISIF-----GRNPVLCLLFSWFLTQMC-LFSDVNKIAXXXXXXXXXXXXXXNMACFL 436
+P +S F P L L+ + + ++ L ++ IA N+ C L
Sbjct: 448 IPLLSPFKKVTANNEPFLGLILTTIIAEIAILMGSMDTIAAVVDFFFLMCYAFVNIICTL 507
Query: 437 LEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCL-LFVIIHYFCP 495
+ APN+RP FK+++ + + LGA+ C M+ + + V LCL ++ + +
Sbjct: 508 HSLLGAPNWRPRFKYYHWFLSLLGAVLCFFIMFST-HWDYAIVACLLCLVIYKYVEWKGA 566
Query: 496 PKPWGDVSQSLIYHQVRKYLLRL--RQDNVKYWRPQVLLMVDNPRTS-------WNLIKF 546
K WGD + L + L+++ ++ + K WRPQ+LL++ + NL+
Sbjct: 567 KKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRPQLLLLLSMQWSKEIIDVRYLNLLNL 626
Query: 547 CNHLKKG-GLYILGHVTVASNFQSEYQELNKQMRAWVNIRDMAGIK----AFVQIGMGPT 601
+ LK G GL ++ + ++ +Q++A ++ DM ++ A +
Sbjct: 627 ASQLKAGKGLTVVTAFLQGDPTSPDDKKKGEQVKARMDF-DMNQVRLRGFAKTLVHSEDQ 685
Query: 602 LPWGIRNVFMGSGLGGMKPNITVLGF 627
+ + + GLGG+KPN ++ +
Sbjct: 686 VRGSMSTLVQSVGLGGLKPNTMLISW 711
Score = 94.0 bits (232), Expect = 1e-18
Identities = 69/197 (35%), Positives = 102/197 (51%), Gaps = 14/197 (7%)
Query: 37 PLQQEQSSKYDLENPHRNKLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLI 96
PL++ QSS + + LG GV++PT ++L + MF+R +++G G+ TFLLL
Sbjct: 16 PLERAQSSSHGGHGAKAD-LGVLLGVYLPTIQHILGVTMFIRLFWLVGIAGLGQTFLLLF 74
Query: 97 LSFIIDVSTTLSISAISTNGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIV 156
L T +SISA++TNG V GGAY+MISR LGPE + + M +V
Sbjct: 75 LCCFCTFLTCISISAVATNGVVESGGAYFMISRNLGPEFGSAVGILFYLANTVATSMYLV 134
Query: 157 GIVE-PLLYNF-GISEGVLTQVLPEGHWYQFG--------YSTVLLLLCLAVAMIGSQTV 206
G VE LLY F G++ G V + FG YST+LLL+ A+ +G + V
Sbjct: 135 GGVEILLLYIFPGLTFG---GVEGQHDTSMFGTMTNSLRFYSTILLLIEFAIVAMGVKFV 191
Query: 207 SRAGNVLFWLLLASTIS 223
V ++ S ++
Sbjct: 192 QMLAPVSLVCVILSILA 208
>CE04364 [P] KOG2083 Na+/K+ symporter
Length = 574
Score = 101 bits (251), Expect = 7e-21
Identities = 84/333 (25%), Positives = 144/333 (43%), Gaps = 14/333 (4%)
Query: 57 GTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAISTNG 116
GT+DGVF +N+ I++FLR G+I+G G+ + LLL + + + T S I
Sbjct: 48 GTWDGVFATVMVNIFGIIVFLRLGWIVGTAGVANSILLLGICTSLALITVFSAIGIVERC 107
Query: 117 TVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLTQV 176
++ GG Y+++S LG + + +G+ VG E + + F ++ +
Sbjct: 108 QIKSGGIYFLVSHVLGHQIGGAIGIIYAFGQAVATGLVAVGFGESVAHLFESESKIMIK- 166
Query: 177 LPEGHWYQFGYSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISVLFVKPFEL 236
G + + L++ AV G V R VL + + LF E
Sbjct: 167 ---------GIAILTLMVLTAVNTAGVTWVVRLQIVLLLTIALAVTDFIFGALFSSEPES 217
Query: 237 NGIVYTGPSLQILKQNLYPKFTKGAAGSVLK-GYETFNDLFGIFFPATAGIFAGAGMSSE 295
++ +++ + Y G + ++F +FG+FF G+ AG MS +
Sbjct: 218 GVFRFSSERIRVNADSHYEAVNCSIIGIPRQIPEQSFFTVFGVFFANFLGVLAGVNMSGD 277
Query: 296 LRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKSLHKDVQIIQTVSGFQSIILVGE 355
L+ P KSIP G L + ++ + I+ LG + L DV I + V+ + LVG
Sbjct: 278 LKDPHKSIPLGELSAVGVSSTICFIFIMILGGVGDRMFLLCDVMISEKVALTGIVFLVGL 337
Query: 356 LSTSLFSVI---VGMVGAAYVLEAISKDNILPG 385
SL S + V A Y+L ++ +L G
Sbjct: 338 YVCSLSSTVGPNDNPVLAGYLLMGVASLFVLLG 370
>CE02791 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transporters
Length = 1020
Score = 97.4 bits (241), Expect = 1e-19
Identities = 92/427 (21%), Positives = 178/427 (41%), Gaps = 67/427 (15%)
Query: 239 IVYTGPSLQILKQNLYPKFT-----------KGAAGSVLKGYETFNDLFGIFFPATAGIF 287
+ + G +++ L N++P++ K A V TF L I+FPA GIF
Sbjct: 335 LAFPGFNMKTLNDNMWPEYMEKSEVVPGVRGKETAEVVQDESSTFFMLMAIYFPAVTGIF 394
Query: 288 AGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVPKKSLHK-------DVQI 340
G MS +LR P +SIP GT+ L T Y ++ I G S+ + L + +
Sbjct: 395 TGTNMSGDLRDPQRSIPVGTIAATLTTSAIYYILAILFGGSITRSVLRDKFGRSIGNTMV 454
Query: 341 IQTVS-GFQSIILVGELSTSLFSVIVGMVGAAYVLEAISKDNILPGISIFGR-----NPV 394
+ +S +++ VG ++ + + + A +L++I+KD+++P ++ F R P
Sbjct: 455 VAALSWPHPAVVTVGAFLSTFGAALQCLCSAPRLLQSIAKDDVIPILAPFARVTKNNEPF 514
Query: 395 LCLLFSWFLTQM-CLFSDVNKIAXXXXXXXXXXXXXXNMACFLLEISSAPNFRPSFKWFN 453
L L+ + + + L V+KIA FL+ +S
Sbjct: 515 LGLVLTVIIAECGILLGAVDKIAEVLDFF------------FLMTLS------------- 549
Query: 454 RYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHYFCPPKPWGDVSQSLIYHQVRK 513
LGA C M+ A ++ +++ + + K WGD + L +
Sbjct: 550 ----LLGAALCFFIMFASSVPLACIACTATAVIYKYVEWKGAKKEWGDGMRGLALTTAQY 605
Query: 514 YLLRL--RQDNVKYWRPQVLLMVDN-------PRTSWNLIKFCNHLKKGGLYILGHVTVA 564
LL++ + + K WRPQVL+++ + R + +++ LK G + +
Sbjct: 606 SLLKVEDKDPHPKNWRPQVLILLTSQWSKEMIDRRAVSMLNLGAQLKAGRGLAIACAFLK 665
Query: 565 SNFQSEYQELNKQMRAWVNIRDMAGIK----AFVQIGMGPTLPWGIRNVFMGSGLGGMKP 620
+ S+ + + ++DM+ ++ A + I ++ G+GG++P
Sbjct: 666 GSVDSQKDKNRARDVKTTLVKDMSSVRLRGFAKTMFYNNHQINGTISGLYQSIGIGGLRP 725
Query: 621 NITVLGF 627
N +L +
Sbjct: 726 NTILLNW 732
Score = 79.7 bits (195), Expect = 2e-14
Identities = 40/108 (37%), Positives = 63/108 (58%)
Query: 56 LGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAISTN 115
LG GV++PT ++L + MF+R +++G G+ T LL + + + T++S+SA++TN
Sbjct: 70 LGVMLGVYLPTIQHILGVTMFIRLFWVVGMSGVAWTMALLAICCLSTLLTSISLSAVATN 129
Query: 116 GTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLL 163
G V GGAY++ISR LG E + + M IVG VE +L
Sbjct: 130 GVVESGGAYFIISRNLGAEFGSAVGILFYLANTVAASMYIVGGVEVIL 177
>7291676 [P] KOG2082 K+/Cl- cotransporter KCC1 and related transporters
Length = 631
Score = 89.7 bits (221), Expect = 2e-17
Identities = 51/177 (28%), Positives = 91/177 (50%), Gaps = 3/177 (1%)
Query: 55 KLGTFDGVFIPTTLNVLSILMFLRFGFIIGQMGILGTFLLLILSFIIDVSTTLSISAIST 114
++GT GVF+P N+ +++F+R +++G G + FL+++ + + T +S+SAI+T
Sbjct: 108 RMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIAT 167
Query: 115 NGTVRGGGAYYMISRCLGPEXXXXXXXXXXXXXXLNSGMNIVGIVEPLLYNFGISEGVLT 174
NG V GG+Y+MISR LGPE L + M IVG VE +L +
Sbjct: 168 NGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFG 227
Query: 175 QVLPEGH--WYQFG-YSTVLLLLCLAVAMIGSQTVSRAGNVLFWLLLASTISIPISV 228
+ + F Y T+LL+ + +G + V++ V ++ S I++ + +
Sbjct: 228 DFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGI 284
Score = 88.2 bits (217), Expect = 6e-17
Identities = 61/236 (25%), Positives = 109/236 (45%), Gaps = 14/236 (5%)
Query: 271 TFNDLFGIFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLLTFVCYSLVIISLGCSVP 330
+F L GIFFP+ GI AG+ S +L KSIP GT+ +L T Y ++ +V
Sbjct: 394 SFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVD 453
Query: 331 K--------KSLHKDVQIIQTVSGFQSIILVGELSTSLFSVIVGMVGAAYVLEAISKDNI 382
+S+ + + Q +IL+G ++L + + + GA +L+AI++D I
Sbjct: 454 NLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEI 513
Query: 383 LPGISIFGRN-----PVLCLLFSWFLTQM-CLFSDVNKIAXXXXXXXXXXXXXXNMACFL 436
+P ++ F ++ P LL + + Q L +V+ +A N+AC +
Sbjct: 514 IPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAV 573
Query: 437 LEISSAPNFRPSFKWFNRYTAFLGAMFCIIAMYVVDNVSASAVISSLCLLFVIIHY 492
+ PN+RP FK+++ + +G CI M + A + +++ I Y
Sbjct: 574 QTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEY 629
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.137 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,873,739
Number of Sequences: 60738
Number of extensions: 2517162
Number of successful extensions: 6008
Number of sequences better than 1.0e-05: 22
Number of HSP's better than 0.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 5859
Number of HSP's gapped (non-prelim): 59
length of query: 1091
length of database: 30,389,216
effective HSP length: 117
effective length of query: 974
effective length of database: 23,282,870
effective search space: 22677515380
effective search space used: 22677515380
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)