ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI2886 check: MH BK KOG2682 Chromatin structure and dynamics NAD-dependent histone deacetylases and class I sirtuins (SIR2 family)
r_klactVI2886 check: MH BK KOG2682 Transcription NAD-dependent histone deacetylases and class I sirtuins (SIR2 family)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI2886 1019887 1018880 -336
(336 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL015c [BK] KOG2682 NAD-dependent histone deacetylases and clas... 322 5e-88
SPCC132.02 [BK] KOG2682 NAD-dependent histone deacetylases and c... 247 2e-65
Hs13775602 [BK] KOG2682 NAD-dependent histone deacetylases and c... 236 4e-62
Hs13775600 [BK] KOG2682 NAD-dependent histone deacetylases and c... 236 4e-62
Hs6912660 [BK] KOG2682 NAD-dependent histone deacetylases and cl... 212 7e-55
7298007 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 163 3e-40
Hs7657575 [BK] KOG2684 Sirtuin 5 and related class III sirtuins ... 155 1e-37
CE06302 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 153 4e-37
YDL042c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 142 7e-34
YOL068c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 141 1e-33
SPBC16D10.07c [BK] KOG2684 Sirtuin 5 and related class III sirtu... 141 1e-33
Hs6912662 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (... 94 4e-19
Hs6912664 [BK] KOG2684 Sirtuin 5 and related class III sirtuins ... 76 6e-14
Hs13787215 [BK] KOG2684 Sirtuin 5 and related class III sirtuins... 76 6e-14
CE02243 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (SI... 75 1e-13
CE02239 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (SI... 75 1e-13
At5g55760 [BK] KOG1905 Class IV sirtuins (SIR2 family) 75 2e-13
7290606 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (SI... 69 7e-12
SPAC1783.04c [BK] KOG2684 Sirtuin 5 and related class III sirtui... 69 1e-11
YOR025w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 69 1e-11
ECU03g0460 [BK] KOG2684 Sirtuin 5 and related class III sirtuins... 69 1e-11
YDR191w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 64 2e-10
Hs7706710 [BK] KOG1905 Class IV sirtuins (SIR2 family) 64 3e-10
CE27656 [BK] KOG1905 Class IV sirtuins (SIR2 family) 62 9e-10
7299319 [BK] KOG1905 Class IV sirtuins (SIR2 family) 59 1e-08
Hs7706712 [BK] KOG1905 Class IV sirtuins (SIR2 family) 51 3e-06
>YPL015c [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 357
Score = 322 bits (825), Expect = 5e-88
Identities = 161/292 (55%), Positives = 203/292 (69%), Gaps = 17/292 (5%)
Query: 2 SAEIPKAIKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAE 61
+A +++K+A +++ NP+ KVIFMVGAGISTS GIPDFRSP TGLYHNL++L LPY E
Sbjct: 5 TASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPE 64
Query: 62 AVFDIEYFEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREA 121
AVFD+++F+ +P PFYTLAKELYPGNF+PS FHYL+KLF+ K+ LKR+YTQNIDTLER+A
Sbjct: 65 AVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQA 124
Query: 122 NISDEFIIEAHGSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIK 181
+ D+ IIEAHGSFA HCI CGK +P + F++KL + ++ CD CG L+K
Sbjct: 125 GVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKL------AEHPIKDFVKCDVCGELVK 178
Query: 182 PKIVFFGEGLPTEFFDTWDLDS-----------STKEKTVCIVCGTSLTVYPFASLPMEA 230
P IVFFGE LP F +TW DS ++ + IV GTSL VYPFASLP E
Sbjct: 179 PAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEI 238
Query: 231 PNSWLRVLLNREIVGDFKTSRQDTDLIFKGSADYAAFLLAQELCWLEDLENL 282
P RVL N E VGDFK +++ TDLI +D A L +EL W ED E +
Sbjct: 239 PRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKI 290
>SPCC132.02 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 332
Score = 247 bits (631), Expect = 2e-65
Identities = 128/276 (46%), Positives = 175/276 (63%), Gaps = 13/276 (4%)
Query: 7 KAIKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDI 66
K ++K+A +++ K+ MVGAGIST++GIPDFRSPETG+Y+NL + NLPYAEAVFD+
Sbjct: 13 KHLEKVASLIKEGKVKKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDL 72
Query: 67 EYFEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDE 126
YF +NP+PFY LA EL P ++P+ HY ++L K L++ YTQNIDTLER A + D+
Sbjct: 73 SYFRKNPRPFYELAHELMPEKYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDK 132
Query: 127 FIIEAHGSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIKPKIVF 186
+IEAHGSF + CI+C E + + ++ +Q C+ C GLIKP IVF
Sbjct: 133 ALIEAHGSFQYSRCIEC-YEMAETEYVRACIMQKQ--------VPKCNSCKGLIKPMIVF 183
Query: 187 FGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLRVLLNREIVGD 246
+GEGLP FF+ ++ TK + +V GTSL V+PFA LP PN RVL+NRE GD
Sbjct: 184 YGEGLPMRFFE--HMEKDTKVCDMALVIGTSLLVHPFADLPEIVPNKCQRVLINREPAGD 241
Query: 247 FKTSRQDTDLIFKGSADYAAFLLAQELCWLEDLENL 282
F + D++ G D L + L W ++LE L
Sbjct: 242 F--GERKKDIMILGDCDSQVRALCKLLGWSDELEKL 275
>Hs13775602 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 352
Score = 236 bits (602), Expect = 4e-62
Identities = 129/292 (44%), Positives = 178/292 (60%), Gaps = 29/292 (9%)
Query: 9 IKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEY 68
++ +A+Y+Q +VI +VGAGISTS+GIPDFRSP TGLY NL K +LPY EA+F+I Y
Sbjct: 27 LEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISY 86
Query: 69 FEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFI 128
F+++P+PF+ LAKELYPG FKP+ HY M+L + K L R YTQNIDTLER A + E +
Sbjct: 87 FKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDL 146
Query: 129 IEAHGSFASNHCI--DCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIKPKIVF 186
+EAHG+F ++HC+ C E+P + K+ + T + C+ C L+KP IVF
Sbjct: 147 VEAHGTFYTSHCVSASCRHEYPLSWMKEKIF--SEVTPK-------CEDCQSLVKPDIVF 197
Query: 187 FGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLRVLLNREIVG- 245
FGE LP FF + S + + +V GTSL V PFASL +AP S R+L+N+E G
Sbjct: 198 FGESLPARFFSC--MQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQ 255
Query: 246 ---------------DFKTSRQDTDLIFKGSADYAAFLLAQELCWLEDLENL 282
DF + + D+ + G D LA+ L W ++LE+L
Sbjct: 256 SDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDL 307
>Hs13775600 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 389
Score = 236 bits (602), Expect = 4e-62
Identities = 129/292 (44%), Positives = 178/292 (60%), Gaps = 29/292 (9%)
Query: 9 IKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEY 68
++ +A+Y+Q +VI +VGAGISTS+GIPDFRSP TGLY NL K +LPY EA+F+I Y
Sbjct: 64 LEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISY 123
Query: 69 FEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFI 128
F+++P+PF+ LAKELYPG FKP+ HY M+L + K L R YTQNIDTLER A + E +
Sbjct: 124 FKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDL 183
Query: 129 IEAHGSFASNHCI--DCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIKPKIVF 186
+EAHG+F ++HC+ C E+P + K+ + T + C+ C L+KP IVF
Sbjct: 184 VEAHGTFYTSHCVSASCRHEYPLSWMKEKIF--SEVTPK-------CEDCQSLVKPDIVF 234
Query: 187 FGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLRVLLNREIVG- 245
FGE LP FF + S + + +V GTSL V PFASL +AP S R+L+N+E G
Sbjct: 235 FGESLPARFFSC--MQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQ 292
Query: 246 ---------------DFKTSRQDTDLIFKGSADYAAFLLAQELCWLEDLENL 282
DF + + D+ + G D LA+ L W ++LE+L
Sbjct: 293 SDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDL 344
>Hs6912660 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 399
Score = 212 bits (539), Expect = 7e-55
Identities = 116/276 (42%), Positives = 162/276 (58%), Gaps = 14/276 (5%)
Query: 8 AIKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIE 67
+++ +A+ ++ +V+ MVGAGIST SGIPDFRSP +GLY NL + +LPY EA+F++
Sbjct: 124 SLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELP 183
Query: 68 YFEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEF 127
+F NPKPF+TLAKELYPGN+KP+ HY ++L K L R+YTQNID LER + I
Sbjct: 184 FFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASK 243
Query: 128 IIEAHGSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIKPKIVFF 187
++EAHG+FAS C C + FP E + D C C G++KP IVFF
Sbjct: 244 LVEAHGTFASATCTVCQRPFPGE---------DIRADVMADRVPRCPVCTGVVKPDIVFF 294
Query: 188 GEGLPTEF-FDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLRVLLNREIVGD 246
GE LP F D + + ++ GTSL V PFASL +S R+L+NR++VG
Sbjct: 295 GEPLPQRFLLHVVDFPMA----DLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGP 350
Query: 247 FKTSRQDTDLIFKGSADYAAFLLAQELCWLEDLENL 282
+ D+ G + L + L W E++ +L
Sbjct: 351 LAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDL 386
>7298007 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 823
Score = 163 bits (413), Expect = 3e-40
Identities = 103/258 (39%), Positives = 145/258 (55%), Gaps = 31/258 (12%)
Query: 23 KVIFMVGAGISTSSGIPDFRSPETGLYHNLSK--LNLPYAEAVFDIEYFEQNPKPFYTLA 80
K+I + GAG+S S GIPDFRS G+Y L+ +LP +A+FDI YF+++P+PFY A
Sbjct: 223 KIIVLTGAGVSVSCGIPDFRSTN-GIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFA 281
Query: 81 KELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFIIEAHGSFASNHC 140
+E+YPG F+PSP H +K+ E+K +L R YTQNIDTLER A I + +IE HGSF++ C
Sbjct: 282 REIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QRVIECHGSFSTASC 339
Query: 141 IDCGKEFPKEAFQNKLLLN----------EQETDEDGGNYATCDGC-----GGLIKPKIV 185
C + +A + + +E D T + G++KP IV
Sbjct: 340 TKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIV 399
Query: 186 FFGEGLPTEFFDTWDLDSSTKEKTVC---IVCGTSLTVYPFASLPMEAPNSWLRVLLNRE 242
FFGEGLP E+ D K VC IV G+SL V P A +P P + ++L+NRE
Sbjct: 400 FFGEGLPDEYHTVMATD-----KDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINRE 454
Query: 243 IVGDFKTSRQ---DTDLI 257
+ K + D+D+I
Sbjct: 455 QLHHLKFDVELLGDSDVI 472
>Hs7657575 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 747
Score = 155 bits (391), Expect = 1e-37
Identities = 97/241 (40%), Positives = 137/241 (56%), Gaps = 23/241 (9%)
Query: 9 IKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSK--LNLPYAEAVFDI 66
I+ K LQ+ K+I + GAG+S S GIPDFRS + G+Y L+ +LP +A+FDI
Sbjct: 243 IEDAVKLLQECK--KIIVLTGAGVSVSCGIPDFRSRD-GIYARLAVDFPDLPDPQAMFDI 299
Query: 67 EYFEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDE 126
EYF ++P+PF+ AKE+YPG F+PS H + L + + +L R YTQNIDTLE+ A I +
Sbjct: 300 EYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGI--Q 357
Query: 127 FIIEAHGSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCG-----GLIK 181
II+ HGSFA+ C+ C + EA + + C C ++K
Sbjct: 358 RIIQCHGSFATASCLICKYKVDCEAVRGDIF---------NQVVPRCPRCPADEPLAIMK 408
Query: 182 PKIVFFGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLRVLLNR 241
P+IVFFGE LP +F D E + IV G+SL V P A +P P+ ++L+NR
Sbjct: 409 PEIVFFGENLPEQFHRAMKYDKD--EVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINR 466
Query: 242 E 242
E
Sbjct: 467 E 467
>CE06302 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 607
Score = 153 bits (386), Expect = 4e-37
Identities = 88/221 (39%), Positives = 124/221 (55%), Gaps = 16/221 (7%)
Query: 24 VIFMVGAGISTSSGIPDFRSPETGLYHNLSKL--NLPYAEAVFDIEYFEQNPKPFYTLAK 81
++ + GAG+S S GIPDFRS + G+Y L +LP A+FDI YF +NP PFY A+
Sbjct: 148 ILVLTGAGVSVSCGIPDFRSKD-GIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAR 206
Query: 82 ELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFIIEAHGSFASNHCI 141
E++PG F PS H +K E+ RL R YTQNIDTLE + I + ++E HGSF+ C
Sbjct: 207 EIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGI--KRVVECHGSFSKCTCT 264
Query: 142 DCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIKPKIVFFGEGLPTEFFDTWDL 201
CG+++ + ++L A C C G+IKP IVFFGE L EF +
Sbjct: 265 RCGQKYDGNEIREEVL---------AMRVAHCKRCEGVIKPNIVFFGEDLGREFHQ--HV 313
Query: 202 DSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLRVLLNRE 242
+ + +V G+SL V P A +P + ++L+NRE
Sbjct: 314 TEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRE 354
>YDL042c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 562
Score = 142 bits (358), Expect = 7e-34
Identities = 101/301 (33%), Positives = 143/301 (46%), Gaps = 37/301 (12%)
Query: 23 KVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEYFEQNPKPFYTLAKE 82
K++ + GAG+STS GIPDFRS E G Y + L L + VF+ F +P FY +A
Sbjct: 256 KILVLTGAGVSTSLGIPDFRSSE-GFYSKIKHLGLDDPQDVFNYNIFMHDPSVFYNIANM 314
Query: 83 LYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFIIEAHGSFASNHCID 142
+ P SP H +K+ + K +L R YTQNID LE A IS + +++ HGSFA+ C+
Sbjct: 315 VLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVT 374
Query: 143 CGKEFPKEAFQNKL-----------LLNEQETDEDGGN----YATCDG-----------C 176
C P E NK+ +E +G N A G
Sbjct: 375 CHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNS 434
Query: 177 GGLIKPKIVFFGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLR 236
G++KP I FFGE LP +F + D + +CI GTSL V P + + P+ +
Sbjct: 435 YGVLKPDITFFGEALPNKFHKSIREDILECDLLICI--GTSLKVAPVSEIVNMVPSHVPQ 492
Query: 237 VLLNREIVGDFKTSRQDTDLIFKGSADYAAFLLAQELCWL---EDLENLSGKQFKPESKT 293
VL+NR+ V + DL G D A ++AQ+ W + +L K FK + K
Sbjct: 493 VLINRDPV-----KHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKNFKCQEKD 547
Query: 294 K 294
K
Sbjct: 548 K 548
>YOL068c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 503
Score = 141 bits (356), Expect = 1e-33
Identities = 93/274 (33%), Positives = 137/274 (49%), Gaps = 29/274 (10%)
Query: 23 KVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEYFEQNPKPFYTLAKE 82
K++ + GAG+STS GIPDFRS E G Y + L L + VF+++ F Q+P FY +A
Sbjct: 202 KILVLTGAGVSTSLGIPDFRSSE-GFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAHM 260
Query: 83 LYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFIIEAHGSFASNHCID 142
+ P SP H +K+ + K +L R YTQNID LE A I + +++ HGSFA+ C+
Sbjct: 261 VLPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVT 320
Query: 143 CGKEFPKE-AFQNKLLL-----------NEQETDEDGGNYATCDGCG---------GLIK 181
C + P E F+N L +Q GN G++K
Sbjct: 321 CHWQIPGEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNSPILKSYGVLK 380
Query: 182 PKIVFFGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLRVLLNR 241
P + FFGE LP+ F T D + +CI GTSL V P + + P+ ++L+NR
Sbjct: 381 PDMTFFGEALPSRFHKTIRKDILECDLLICI--GTSLKVAPVSEIVNMVPSHVPQILINR 438
Query: 242 EIVGDFKTSRQDTDLIFKGSADYAAFLLAQELCW 275
++V + + DL G D A L+A++ W
Sbjct: 439 DMV-----THAEFDLNLLGFCDDVASLVAKKCHW 467
>SPBC16D10.07c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 471
Score = 141 bits (356), Expect = 1e-33
Identities = 96/285 (33%), Positives = 147/285 (50%), Gaps = 33/285 (11%)
Query: 24 VIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEYFEQNPKPFYTLAKEL 83
V+ +VGAGISTS GI DFRS + G Y L++ L +FDI F +NP+ FYT A++L
Sbjct: 155 VVVLVGAGISTSLGILDFRS-DNGFYARLARHGLSEPSEMFDIHTFRENPEIFYTFARDL 213
Query: 84 YPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFIIEAHGSFASNHCIDC 143
P SP H ++L E KN+L ++TQNID LE++ +SD II+ HGSFA+ CI C
Sbjct: 214 LPETNHYSPSHAFIRLLEKKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKC 273
Query: 144 -----GKEFPKEAFQNKLLL------------------NEQETDEDGGNYATCDGCG--G 178
G E ++ ++ E+ DG + ++ D G
Sbjct: 274 KHKVDGSELYEDIRNQRVSYCNECGKPPLKLRRVGQNKKEKHYFSDGDSESSEDDLAQPG 333
Query: 179 LIKPKIVFFGEGLPTEFFDTWDLDSSTKEKTVCIVC-GTSLTVYPFASLPMEAPNSWLRV 237
++KP I FFGE LP FF+ + S E+T ++C GTSL V P + L P + ++
Sbjct: 334 IMKPDITFFGEALPDSFFN--KVGSGELEETDLLICIGTSLKVAPVSELISVIPPTTPQI 391
Query: 238 LLNREIVGDFKTSRQDTDLIFKGSADYAAFLLAQELCWLEDLENL 282
++R V + ++ D + + D+ + + WL +L+ L
Sbjct: 392 YISRTPV---RHTQFDVNFL-SPYCDWVIVEICKRAGWLNELQAL 432
>Hs6912662 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family)
Length = 314
Score = 93.6 bits (231), Expect = 4e-19
Identities = 67/238 (28%), Positives = 113/238 (47%), Gaps = 34/238 (14%)
Query: 6 PKAIKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFD 65
P+ +K+L +++ + +++ M GAGIST SGIPD+RS + GLY + + + + V
Sbjct: 41 PEKVKELQRFITLSK--RLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRS 98
Query: 66 I----EYFEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREA 121
Y+ +N + + + +P+P H+ + +E +L + TQN+D L +A
Sbjct: 99 APIRQRYWARNFVGWPQFS------SHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKA 152
Query: 122 NISDEFIIEAHGSFASNHCIDCGKEFPKEAFQNKL-LLNEQETDEDGG------------ 168
+ E HG C+DCG++ P+ Q + +LN + E G
Sbjct: 153 --GSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEE 210
Query: 169 -----NYATCDGCGGLIKPKIVFFGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVY 221
TC CGG +KP +VFFG+ + + D + KE +V G+SL VY
Sbjct: 211 QVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDF--VHKRVKEADSLLVVGSSLQVY 266
>Hs6912664 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 310
Score = 76.3 bits (186), Expect = 6e-14
Identities = 65/220 (29%), Positives = 102/220 (45%), Gaps = 33/220 (15%)
Query: 24 VIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEYFEQNPK---PFYTLA 80
++ + GAG+S SG+P FR G + +L A F NP FY
Sbjct: 53 IVIISGAGVSAESGVPTFRGAG-GYWRKWQAQDLATPLA------FAHNPSRVWEFYHYR 105
Query: 81 KELYPGNFKPSPFHYLMKLFESK----NRLKRIYTQNIDTLEREANISDEFIIEAHGSFA 136
+E+ G+ +P+ H + E++ R + TQNID L R+A + ++E HGS
Sbjct: 106 REVM-GSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKN--LLEIHGSLF 162
Query: 137 SNHCIDCGKEFPKEAFQNKLL--LNEQETDEDGGNYAT--------CD--GCGGLIKPKI 184
C CG E +++ + L+ + E G A+ C+ GCGGL++P +
Sbjct: 163 KTRCTSCG--VVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHV 220
Query: 185 VFFGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFA 224
V+FGE L + ++D +C+V GTS VYP A
Sbjct: 221 VWFGENLDPAILE--EVDRELAHCDLCLVVGTSSVVYPAA 258
>Hs13787215 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 299
Score = 76.3 bits (186), Expect = 6e-14
Identities = 65/220 (29%), Positives = 102/220 (45%), Gaps = 33/220 (15%)
Query: 24 VIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEYFEQNPK---PFYTLA 80
++ + GAG+S SG+P FR G + +L A F NP FY
Sbjct: 53 IVIISGAGVSAESGVPTFRGAG-GYWRKWQAQDLATPLA------FAHNPSRVWEFYHYR 105
Query: 81 KELYPGNFKPSPFHYLMKLFESK----NRLKRIYTQNIDTLEREANISDEFIIEAHGSFA 136
+E+ G+ +P+ H + E++ R + TQNID L R+A + ++E HGS
Sbjct: 106 REVM-GSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKN--LLEIHGSLF 162
Query: 137 SNHCIDCGKEFPKEAFQNKLL--LNEQETDEDGGNYAT--------CD--GCGGLIKPKI 184
C CG E +++ + L+ + E G A+ C+ GCGGL++P +
Sbjct: 163 KTRCTSCG--VVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHV 220
Query: 185 VFFGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFA 224
V+FGE L + ++D +C+V GTS VYP A
Sbjct: 221 VWFGENLDPAILE--EVDRELAHCDLCLVVGTSSVVYPAA 258
>CE02243 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family)
Length = 287
Score = 75.5 bits (184), Expect = 1e-13
Identities = 54/194 (27%), Positives = 89/194 (45%), Gaps = 33/194 (17%)
Query: 23 KVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEYFEQN--PKPFYTLA 80
K++ + GAGIST SGIPD+RS + GLY ++ + ++ +Y N + +++
Sbjct: 29 KLLVISGAGISTESGIPDYRSKDVGLYARIAH------KPIYFQDYMRSNRCRQRYWSRN 82
Query: 81 KELYP--GNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFIIEAHGSFASN 138
+P G P+ HY + +E+ +R + + TQN+D L +A + + E HGS
Sbjct: 83 FLAWPRFGQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKA--GSKMVTELHGSALQV 140
Query: 139 HCIDCGKEFPKEAFQNKL------------LLNEQETD---------EDGGNYATCDGCG 177
C C ++ +Q++L E D E G C CG
Sbjct: 141 KCTTCDYIESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCG 200
Query: 178 GLIKPKIVFFGEGL 191
GL+K + FFGE +
Sbjct: 201 GLMKTDVTFFGENV 214
>CE02239 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family)
Length = 287
Score = 75.1 bits (183), Expect = 1e-13
Identities = 60/223 (26%), Positives = 97/223 (42%), Gaps = 35/223 (15%)
Query: 23 KVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEYFEQNP--KPFYTLA 80
K++ + GAGIST SGIPD+RS + GLY + E ++ ++ + + +++ +
Sbjct: 29 KLLIITGAGISTESGIPDYRSKDVGLYTKTA------LEPIYFQDFMKSKKCRQRYWSRS 82
Query: 81 KELYP--GNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFIIEAHGSFASN 138
+P P+ HY + +E+ N+ + TQN+D L +A + I E HG+
Sbjct: 83 YLNWPRFAQALPNFNHYALSKWEAANKFHWLITQNVDGLHLKA--GSKMITELHGNALQV 140
Query: 139 HCIDCGKEFPKEAFQNKLLL------------NEQETD---------EDGGNYATCDGCG 177
C C ++ +Q++L +QE D E G C CG
Sbjct: 141 KCTSCEYIETRQTYQDRLNYANPGFKEQFVSPGQQELDADTALPLGSEQGFKIPECLNCG 200
Query: 178 GLIKPKIVFFGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTV 220
GL+K + FGE L T+ E + GTSL V
Sbjct: 201 GLMKTDVTLFGENLNTDKIKV--CGKKVNECNGVLTLGTSLEV 241
>At5g55760 [BK] KOG1905 Class IV sirtuins (SIR2 family)
Length = 473
Score = 74.7 bits (182), Expect = 2e-13
Identities = 61/227 (26%), Positives = 99/227 (42%), Gaps = 43/227 (18%)
Query: 9 IKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLY------HNLSKLNLPYAEA 62
I++LAK +Q + + V GAGISTS GIPDFR P+ G++ +L K +LP+ A
Sbjct: 34 IEELAKLIQKSKHLVVF--TGAGISTSCGIPDFRGPK-GIWTLQREGKDLPKASLPFHRA 90
Query: 63 VFDIEYFEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREAN 122
+ PS H + E LK + +QN+D L +
Sbjct: 91 M--------------------------PSMTHMALVELERAGILKFVISQNVDGLHLRSG 124
Query: 123 ISDEFIIEAHGSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIKP 182
I E + E HG C CG E+ ++ + L E + + CG +K
Sbjct: 125 IPREKLSELHGDSFMEMCPSCGAEYLRDFEVETIGLKET------SRKCSVEKCGAKLKD 178
Query: 183 KIVFFGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPME 229
++ + + LP + D + + +C+ GTSL + P +LP++
Sbjct: 179 TVLDWEDALPPKEIDPAEKHCKKADLVLCL--GTSLQITPACNLPLK 223
>7290606 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family)
Length = 204
Score = 69.3 bits (168), Expect = 7e-12
Identities = 48/157 (30%), Positives = 74/157 (46%), Gaps = 24/157 (15%)
Query: 9 IKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEY 68
IK+L +L P+V V+ GAGIST SGIPD+RS GLY + + + E V
Sbjct: 35 IKRLEDFLLSKPNVLVL--TGAGISTESGIPDYRSEGVGLYARSNHKPVQHMEFV----- 87
Query: 69 FEQNPKPFYTLAKELYPGNF---------KPSPFHYLMKLFESKNRLKRIYTQNIDTLER 119
+ K + NF +P+ H+ + FE + R++ + TQN+D L
Sbjct: 88 ------KSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHT 141
Query: 120 EANISDEFIIEAHGSFASNHCIDCGKEFPKEAFQNKL 156
+A + ++E HGS C+ C + FQ+ L
Sbjct: 142 KAGSRN--VVEVHGSGYVVKCLSCEYRIDRHEFQSIL 176
>SPAC1783.04c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 415
Score = 68.9 bits (167), Expect = 1e-11
Identities = 64/225 (28%), Positives = 99/225 (43%), Gaps = 32/225 (14%)
Query: 23 KVIFMVGAGISTSSGIPDFRSPETGLYHNLS---KLNLPYAEAVFDIEYFE--QNPKPFY 77
+++ + GAGIS +GIPDFRS E GL+ +L KLN E +FD + ++ F+
Sbjct: 59 RIVVVTGAGISCDAGIPDFRSSE-GLFSSLRAEYKLNCSGKE-LFDGSVYRDLKSVNIFH 116
Query: 78 TLAKELY--PGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFI------- 128
+ ++L+ N +P+ FH + +++L R+YTQNID LE I
Sbjct: 117 AMIRKLHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFLETRLEGLQTCIPLPQSAP 176
Query: 129 ----IEAHGSFASNHCIDCG--KEFPKEAFQNKLLL------NEQETDEDGGNYATCDGC 176
I HG+ C C K+F + F + E E G + +GC
Sbjct: 177 WPTTIPLHGTLEVVSCTRCSFLKKFNPDIFDRNGVTVCPDCKTENEVRRIAGKRSVIEGC 236
Query: 177 GGLIKPKIVFFGEGLPTEFFDTWDLDSSTKEKTVC-IVCGTSLTV 220
++P+IV + E P K + C IV GTS +
Sbjct: 237 ---LRPRIVLYNEIHPDSESIGSVCSQDLKSRPDCLIVAGTSCKI 278
>YOR025w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 447
Score = 68.6 bits (166), Expect = 1e-11
Identities = 64/243 (26%), Positives = 99/243 (40%), Gaps = 54/243 (22%)
Query: 23 KVIFMVGAGISTSSGIPDFRSPETGLYHNLSK-----LNLPYAEAVFDIEYFEQNPKP-- 75
++ + GAGIS ++GIPDFRS + GLY + K ++ +FDI F + K
Sbjct: 54 RIACLTGAGISCNAGIPDFRSSD-GLYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISI 112
Query: 76 FYTLAKELYPGN--FKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANIS--------- 124
F + LY KP+ H + + +N+L R YTQNID LE ++
Sbjct: 113 FAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLT 172
Query: 125 -------DEFIIEAHGSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCG 177
+ +++ HG + C C + FP + ++ L G C C
Sbjct: 173 SFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRR--------GELPLCPDCE 224
Query: 178 ------------------GLIKPKIVFFGEGLPTEFFDT--WDLDSSTKEKTVCIVCGTS 217
G+++P IV +GE P+ T +LD I+ GTS
Sbjct: 225 ALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLIIMGTS 284
Query: 218 LTV 220
L V
Sbjct: 285 LKV 287
>ECU03g0460 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 425
Score = 68.6 bits (166), Expect = 1e-11
Identities = 63/227 (27%), Positives = 100/227 (43%), Gaps = 42/227 (18%)
Query: 23 KVIFMVGAGISTSSGIPDFRSPETGLYHNLSK-LNLPYAEA-VFDIEYFEQNPKPFYTLA 80
+V+ + GAGIS SSGIPDFRS ++GL++++ K L + + + + ++ K +
Sbjct: 87 RVVVITGAGISVSSGIPDFRS-KSGLFNDIKKDLGVSGNDLFTYSLSMSKELRKGYLRYI 145
Query: 81 KEL--YPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANIS-----DEFIIEAHG 133
+L +PS H + L+ +R RIYTQNID LE +A ++ ++ HG
Sbjct: 146 SKLKNMVDKAQPSATHEFLSLYSDISRRFRIYTQNIDGLEEKAGLAATKDRSTRLVYLHG 205
Query: 134 SFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDG-GNYATCDGC---------------G 177
+ S C+ CG K+ + E D G G C GC
Sbjct: 206 NMKSLGCLYCG---------YKIEFGDAERDAYGRGEEIVCAGCVRRNEKRGRDVRKRPV 256
Query: 178 GLIKPKIVFFGEGLPTEFFDTWDLDSSTKEKTVC---IVCGTSLTVY 221
G+ I+ + + P F + + C IV GTSL V+
Sbjct: 257 GVFHTTIIHYNQSHPDSSF----ISKMAEHDNTCDLFIVMGTSLKVF 299
>YDR191w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 370
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/235 (25%), Positives = 100/235 (41%), Gaps = 42/235 (17%)
Query: 19 NPDVKVIFMVGAGISTSSGIPDFRSPET-------GLYHNLSKLNLPYAEAVFDIEYFEQ 71
N +++ + GAGIS ++GIPDFRS E G +L N Y + ++ F Q
Sbjct: 90 NYSKRMVVVSGAGISVAAGIPDFRSSEGIFSTVNGGSGKDLFDYNRVYGDESMSLK-FNQ 148
Query: 72 NPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLERE-ANISDEF--- 127
+ L+K N +P+ FH ++ F RL R+YTQNID L+ + ++S
Sbjct: 149 LMVSLFRLSK-----NCQPTKFHEMLNEFARDGRLLRLYTQNIDGLDTQLPHLSTNVPLA 203
Query: 128 -----IIEAHGSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCG----- 177
++ HGS C C P F +L + + D +C C
Sbjct: 204 KPIPSTVQLHGSIKHMECNKCLNIKP---FDPELFKCDDKFDSRTEIIPSCPQCEEYETV 260
Query: 178 -----------GLIKPKIVFFGEGLPTEFFDTWDLDSSTKEKTVC-IVCGTSLTV 220
G ++P+++ + E P F ++ K++ C I+ GTSL +
Sbjct: 261 RKMAGLRSTGVGKLRPRVILYNEVHPEGDFIGEIANNDLKKRIDCLIIVGTSLKI 315
>Hs7706710 [BK] KOG1905 Class IV sirtuins (SIR2 family)
Length = 355
Score = 63.9 bits (154), Expect = 3e-10
Identities = 67/321 (20%), Positives = 127/321 (38%), Gaps = 47/321 (14%)
Query: 4 EIPKAIKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAV 63
E+ + + +LA+ + + V +F GAGIST+SGIPDFR P G++ + P +
Sbjct: 29 ELERKVWELARLVWQSSSV--VFHTGAGISTASGIPDFRGPH-GVWTMEERGLAPKFDTT 85
Query: 64 FDIEYFEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANI 123
F+ + +P+ H + E L+ + +QN+D L +
Sbjct: 86 FE---------------------SARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGF 124
Query: 124 SDEFIIEAHGSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIKPK 183
+ + E HG+ C C ++ ++ + L C G ++
Sbjct: 125 PRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDT 184
Query: 184 IVFFGEGLPTEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLRVLLNREI 243
I+ + + LP D D +++ + I GTSL + P +LP+ R +
Sbjct: 185 ILDWEDSLPDR--DLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRG-----GRLV 237
Query: 244 VGDFKTSRQD--TDLIFKGSADYAAFLLAQEL-----CW---------LEDLENLSGKQF 287
+ + + ++ D DL G D L + L W L L +
Sbjct: 238 IVNLQPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKL 297
Query: 288 KPESKTKTKVHINKPEPEQQE 308
+P+ ++ T+++ + P +QE
Sbjct: 298 EPKEESPTRINGSIPAGPKQE 318
>CE27656 [BK] KOG1905 Class IV sirtuins (SIR2 family)
Length = 299
Score = 62.4 bits (150), Expect = 9e-10
Identities = 56/224 (25%), Positives = 97/224 (43%), Gaps = 29/224 (12%)
Query: 15 YLQDNPDVKVIF-MVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAV-FDIEYFEQN 72
++Q K IF ++GAG+ST S +PDFR + G++ + +AE V F +
Sbjct: 48 FVQAKQTGKPIFVLIGAGVSTGSKLPDFRGKQ-GVW--TLQAEGKHAEGVDFQVA----- 99
Query: 73 PKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFIIEAH 132
+P H + +K I TQN+D L+R+ I E +IE H
Sbjct: 100 ----------------RPGVSHKSILALHKAGYIKTIITQNVDGLDRKVGIPVEDLIEVH 143
Query: 133 GSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIKPKIVFFGEGLP 192
G+ C C E+ +E + L + + GN T C G ++ + + +
Sbjct: 144 GNLFLEVCQSCFSEYVREEIVMSVGLCPTGRNCE-GNKRTGRSCRGKLRDATLDWDTEIS 202
Query: 193 TEFFDTWDLDSSTKEKTVCIVCGTSLTVYPFASLPMEAPNSWLR 236
D + + K+ + + GTSL + P SLP++A + ++
Sbjct: 203 LNHLDR--IRKAWKQTSHLLCIGTSLEIIPMGSLPLDAKSKGIK 244
>7299319 [BK] KOG1905 Class IV sirtuins (SIR2 family)
Length = 317
Score = 58.9 bits (141), Expect = 1e-08
Identities = 52/213 (24%), Positives = 91/213 (42%), Gaps = 37/213 (17%)
Query: 24 VIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAVFDIEYFEQNPKPFYTLAKEL 83
V+ GAGISTS+GIPDFR P + V+ +E E+ KP + ++ +
Sbjct: 47 VVLHTGAGISTSAGIPDFRGP----------------KGVWTLE--EKGEKPDFNVSFD- 87
Query: 84 YPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANISDEFIIEAHGSFASNHCIDC 143
+P+ H + ++ + +QNID L ++ + +++ E HG+ C C
Sbjct: 88 ---EARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKC 144
Query: 144 GKEFPK----EAFQNKLLLNEQETDEDGGNYATCDGCGGLIKPKIVFFGEGLPTEFFDTW 199
++F E K L ++ D +C G++ ++ + LP
Sbjct: 145 RRQFVSPSAVETVGQKSLQRACKSSMDSKG-RSCR--SGILYDNVLDWEHDLPEN----- 196
Query: 200 DLDSSTKEKTVC---IVCGTSLTVYPFASLPME 229
DL+ TV I GT+L + P LP++
Sbjct: 197 DLEMGVMHSTVADLNIALGTTLQIVPSGDLPLK 229
>Hs7706712 [BK] KOG1905 Class IV sirtuins (SIR2 family)
Length = 400
Score = 50.8 bits (120), Expect = 3e-06
Identities = 54/222 (24%), Positives = 85/222 (37%), Gaps = 44/222 (19%)
Query: 4 EIPKAIKKLAKYLQDNPDVKVIFMVGAGISTSSGIPDFRSPETGLYHNLSKLNLPYAEAV 63
E+ A++ AKYL + GAGIST++ IPD+R P G++ L K A +
Sbjct: 91 ELASAVRN-AKYL--------VVYTGAGISTAASIPDYRGP-NGVWTLLQKGRSVSAADL 140
Query: 64 FDIEYFEQNPKPFYTLAKELYPGNFKPSPFHYLMKLFESKNRLKRIYTQNIDTLEREANI 123
+ E P+ H + + ++ + +QN D L + +
Sbjct: 141 SEAE----------------------PTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGL 178
Query: 124 SDEFIIEAHGSFASNHCIDCGKEFPKEAFQNKLLLNEQETDEDGGNYATCDGCGGLIKPK 183
I E HG+ C C P + + E+ TC CG ++
Sbjct: 179 PRTAISELHGNMYIEVCTSC---VPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDT 235
Query: 184 IVFFGE----GLPTEFFDTWDLDSSTKEKTVCIVC-GTSLTV 220
IV FGE G P W+ + + I+C G+SL V
Sbjct: 236 IVHFGERGTLGQPL----NWEAATEAASRADTILCLGSSLKV 273
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.137 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,259,280
Number of Sequences: 60738
Number of extensions: 984373
Number of successful extensions: 2722
Number of sequences better than 1.0e-05: 26
Number of HSP's better than 0.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 2649
Number of HSP's gapped (non-prelim): 30
length of query: 336
length of database: 30,389,216
effective HSP length: 107
effective length of query: 229
effective length of database: 23,890,250
effective search space: 5470867250
effective search space used: 5470867250
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)