ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI2896 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI2896 1021058 1022794 579
(579 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL125c [G] KOG2504 Monocarboxylate transporter 205 2e-52
YKL221w [G] KOG2504 Monocarboxylate transporter 162 1e-39
YOR306c [G] KOG2504 Monocarboxylate transporter 81 4e-15
Hs22064599 [G] KOG2504 Monocarboxylate transporter 71 4e-12
Hs4759112 [G] KOG2504 Monocarboxylate transporter 70 7e-12
Hs4759116 [G] KOG2504 Monocarboxylate transporter 65 2e-10
YOL119c [G] KOG2504 Monocarboxylate transporter 64 6e-10
7292012 [G] KOG2504 Monocarboxylate transporter 64 6e-10
Hs7019529 [G] KOG2504 Monocarboxylate transporter 61 4e-09
CE21446 [G] KOG2504 Monocarboxylate transporter 57 6e-08
CE20478 [G] KOG2504 Monocarboxylate transporter 57 6e-08
7295764 [G] KOG2504 Monocarboxylate transporter 55 2e-07
Hs4759118 [G] KOG2504 Monocarboxylate transporter 55 3e-07
Hs20559959 [G] KOG2504 Monocarboxylate transporter 55 3e-07
7303156 [G] KOG2504 Monocarboxylate transporter 52 3e-06
7290288 [G] KOG2504 Monocarboxylate transporter 51 4e-06
7303008 [G] KOG2504 Monocarboxylate transporter 51 5e-06
7302291 [G] KOG2504 Monocarboxylate transporter 51 5e-06
>YNL125c [G] KOG2504 Monocarboxylate transporter
Length = 673
Score = 205 bits (521), Expect = 2e-52
Identities = 132/464 (28%), Positives = 207/464 (44%), Gaps = 31/464 (6%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GGYGW+ CV + F TWG N +GV L+YYL+ + +P A+ D+A+I
Sbjct: 209 GGYGWVVTFCVFLTMFSTWGCNASFGVDLAYYLNHDTYPGASKYDYALIAGLTVFLGQLL 268
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
M G R ML G + +LY T G ++G + IF +
Sbjct: 269 SPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVPAT 328
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVFNTI 319
V+PGWFLKKRA A G++ +G G GG+V A + ++ G+ +W +R +GI + +
Sbjct: 329 TVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNTRWCLRIIGISCSISVLV 388
Query: 320 AALIVKIRVPRNPPP------QKSSLQLLKDVYDFNVYKLTPLQYCTLWSTMTNIGYVIL 373
A ++K RNP P ++ + LK ++ V + LW Y ++
Sbjct: 389 AIALLK---ERNPTPAIGLKSPRAMFEQLKAMFSLKVITKPFVVLIALWFMFALFAYNMM 445
Query: 374 LFSLSNYALSIGLNSQQATVTLALFNGAQIIGRPAMGYFSEKIGRVNCTSICMFYTILLL 433
+F+LS+YA+S GL+S A+ A+ NG+Q IGRP MG +K GR N T + + +
Sbjct: 446 VFTLSSYAISKGLSSHDASTLTAILNGSQSIGRPLMGLAGDKFGRANVTIVLTTLLTIYM 505
Query: 434 GPYWFNVDSYSAIXXXXXXXXXXXXVSSVNVIPLIADVTGMAHFPAGLGYNNIWNGSTAV 493
+W ++ + V++V LIAD+ F + N +
Sbjct: 506 FAFWIPAHTFVQLIFFSILVGSCVGVANVMNTVLIADMVKPEEFLPAWAFVNYCGAPFLL 565
Query: 494 VAEIFALKLR-DYSLPQPYLHCQIFVLVMYFVGLLALIPYREWKVRRMLNARISGKN--- 549
V E+ A L + PYLH QIF + L+ + RE+ +R L R + N
Sbjct: 566 VCEVIAQALTVEKDKSNPYLHAQIFCGCCFIAALILISILREYSIRMKLTERQAMTNEKL 625
Query: 550 ------------VDD------KIRLKWHRVLEPGVLNYFKRAFY 575
D+ + + K+ +L PG+ YF R Y
Sbjct: 626 KEWKASEYDTDSADEDWGKLKERKTKYDLLLGPGIKKYFLRMVY 669
>YKL221w [G] KOG2504 Monocarboxylate transporter
Length = 473
Score = 162 bits (411), Expect = 1e-39
Identities = 114/453 (25%), Positives = 192/453 (42%), Gaps = 38/453 (8%)
Query: 101 QDVVSRRNTCRKDSVEGSIP---EIEDDGLYNAXXXXXXXXXGGYGWICCACVVVMNFCT 157
+DV ++ N KD + G+ E+ D GGYGW ++ NF T
Sbjct: 11 RDVENKLNLNGKDDINGNTSISIEVPD---------------GGYGWFILLAFILYNFST 55
Query: 158 WGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXXXXXSAMCMNKFGYRPVML 217
WG N+ Y ++L++YL +N F + D+A I + F + ++
Sbjct: 56 WGANSGYAIYLAHYLENNTFAGGSKLDYASIGGLAFSCGLFFAPVITWLYHIFSIQFIIG 115
Query: 218 VGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNSVVIPGWFLKKRAFANGLT 277
+G+L Q E+Y T G+L+GF FIF + +IP WF KR+ A+G+
Sbjct: 116 LGILFQGAALLLAAFSVTLWEIYLTQGVLIGFGLAFIFIPSVTLIPLWFRNKRSLASGIG 175
Query: 278 HIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVFNTIAALIVKIRVPRNPPPQKS 337
G GLGG+V + +I++K G KW + I+ +TIA ++ +
Sbjct: 176 TAGSGLGGIVFNLGMQSILQKRGV-KWALIAQCIICTSLSTIALMLTR--------TTHQ 226
Query: 338 SLQLLKDVYDFNVYKLTPLQYCTLW-----STMTNIGYVILLFSLSNYALSIGLNSQQAT 392
L+ K Y F + L +W + +GYV+LL+SLS++ +S+G S+Q +
Sbjct: 227 GLRQHKRSYKFELLDYDVLSNFAVWLLFGFVSFAMLGYVVLLYSLSDFTVSLGYTSKQGS 286
Query: 393 VTLALFNGAQIIGRPAMGYFSEKIGRVNCTSICMFYTILLLGPYWFNVDSYSAIXXXXXX 452
+ + ++GRP +G+ ++K G + I +L W + +
Sbjct: 287 YVSCMVSVGSLLGRPIVGHIADKYGSLTVGMILHLVMAILCWAMWIPCKNLATAIRFGLL 346
Query: 453 XXXXXXVSSVNVIPLIADVTGMAHFPAGLGYNNIWNGSTAVVAEIFALKLRDYSL-PQPY 511
+ ++ + G+ P G I+ + A+VA I L+LR Y
Sbjct: 347 VGSIMGTIWPTIASIVTRIVGLQKLPGTFGSTWIFMAAFALVAPIIGLELRSTDTNGNDY 406
Query: 512 LHCQIFVLVMYFVGLLALIPYREWKVRRMLNAR 544
IFV YF L +W +R + AR
Sbjct: 407 YRTAIFVGFAYFGVSLC-----QWLLRGFIIAR 434
>YOR306c [G] KOG2504 Monocarboxylate transporter
Length = 521
Score = 81.3 bits (199), Expect = 4e-15
Identities = 66/306 (21%), Positives = 119/306 (38%), Gaps = 19/306 (6%)
Query: 151 VVMNFCTWGPNTCYGVF-----LSYYLSSNYFPNATPTDFAVIXXXXXXXXXXXXXXSAM 205
VV C G C+G+ + +L N + + + + S
Sbjct: 108 VVTFGCFLGLIACFGLLNSTGVIESHLQDNQLSSESVSTIGWLFSLFLFVCSASCIISGT 167
Query: 206 CMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNSVVIPGW 265
++ G+R +M+VG + ++ I+ GF NG + V +
Sbjct: 168 YFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHY 227
Query: 266 FLKKRAFANGLTHIGVGLGGLVLT------FAVHAIMEKTGSHKWPMRFLGIMVLVFNTI 319
F K+R A + IG +GG+V F++ + + T W +R LG + L T+
Sbjct: 228 FFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSDTDPTYGFVWGIRTLGFLDLALLTL 287
Query: 320 AALIVKIRVP---RNPPPQKSSLQLLKDVY-----DFNVYKLTPLQYCTLWSTMTNIGYV 371
+ ++VK R+P N +S + + VY D + +C L + + +
Sbjct: 288 SIILVKERLPHVIENSKDGESRWRYILRVYILQCFDAKAFLDMKYLFCVLGTVFSELSIN 347
Query: 372 ILLFSLSNYALSIGLNSQQATVTLALFNGAQIIGRPAMGYFSEKIGRVNCTSICMFYTIL 431
L +YA S G+++ A + + N I GR GY S+K GR N + +
Sbjct: 348 SALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFI 407
Query: 432 LLGPYW 437
++ W
Sbjct: 408 VMFVGW 413
>Hs22064599 [G] KOG2504 Monocarboxylate transporter
Length = 579
Score = 71.2 bits (173), Expect = 4e-12
Identities = 62/277 (22%), Positives = 113/277 (40%), Gaps = 9/277 (3%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GG+GW+ A +N ++G G L++ + +F + D A I
Sbjct: 143 GGWGWVVAAAAFAINGLSYGLLRSLG--LAFPDLAEHFDRSAQ-DTAWISALALAVQQAA 199
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
+ ++G RPV++VG +L LY G+L GF +F
Sbjct: 200 SPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPAL 259
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVFNTI 319
+ +F ++R A GL G G L+L A+ +++ G + + LG + L
Sbjct: 260 GTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFG-WRGALLLLGAITLHLTPC 318
Query: 320 AALIVKIRVPRNPP-PQKSSLQLLKDVYDFNVYKLTPLQYCTLWSTMTNIGYVILLFSLS 378
AL++ + +P +PP P +S L L +++ L + + GY + L+
Sbjct: 319 GALLLPLVLPGDPPAPPRSPLAAL----GLSLFTRRAFSIFALGTALVGGGYFVPYVHLA 374
Query: 379 NYALSIGLNSQQATVTLALFNGAQIIGRPAMGYFSEK 415
+AL GL A + +A+ R G+ +++
Sbjct: 375 PHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQ 411
>Hs4759112 [G] KOG2504 Monocarboxylate transporter
Length = 465
Score = 70.5 bits (171), Expect = 7e-12
Identities = 72/296 (24%), Positives = 121/296 (40%), Gaps = 23/296 (7%)
Query: 140 GGYGW-ICCACVVVMNFCTWGPNTCYGVF--LSYYLSSNYFPNATPTDFAVIXXXXXXXX 196
GG+GW + C V+ F P F L Y +D A I
Sbjct: 18 GGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGY------SDTAWISSILLAML 71
Query: 197 XXXXXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFG 256
++C+N+FG RPVMLVG L ++Y T G++ G F
Sbjct: 72 YGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQ 131
Query: 257 CNSVVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVF 316
+ +++ +F K+R ANGL G + L+ + ++ G W FL + L+
Sbjct: 132 PSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYG---WRGGFLILGGLLL 188
Query: 317 N--TIAALIVKIRVPRNP---PPQKSSLQLLKDVYDFNVYKLTPLQYCTLWSTMTNIGYV 371
N AAL+ + V P PP+ S + + D +V++ + +++ +G
Sbjct: 189 NCCVCAALMRPLVVTAQPGSGPPRPS-----RRLLDLSVFRDRGFVLYAVAASVMVLGLF 243
Query: 372 ILLFSLSNYALSIGLNSQQATVTLALFNGAQIIGRPAMGYFSEKIGRVNCTSICMF 427
+ + +YA +G+ +A L + I RPA G F +G+V S+ +F
Sbjct: 244 VPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAG-FVAGLGKVRPYSVYLF 298
>Hs4759116 [G] KOG2504 Monocarboxylate transporter
Length = 505
Score = 65.5 bits (158), Expect = 2e-10
Identities = 78/394 (19%), Positives = 143/394 (35%), Gaps = 43/394 (10%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
G + W+ +V T G TC G+F + N+ + F I
Sbjct: 10 GSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILTAVLHMAGPL 69
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
++ + +FG R +++G +L +LYFT G + G F F +
Sbjct: 70 ---CSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSI 126
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMV--LVFN 317
V+ +F+++R AN L +GV LG + ++E G + F GI + +
Sbjct: 127 TVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICG 186
Query: 318 TIAALIVKIRVPRN-----PPPQKSSL-------QLLKDVYDFNVYKLTPLQYC-----T 360
I + P PPP+ +L + ++ F++ + YC
Sbjct: 187 AIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHN-TGYCVYILGV 245
Query: 361 LWSTMTNIGYVILLFSLSNYALSIGLNSQQATVTLALFNGAQIIGRPAMGYFSEKIGRVN 420
+WS +G+ + L YA+ ++ QQA + +++ + I RP G + + +
Sbjct: 246 MWSV---LGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFAS 302
Query: 421 CTSICMFYTILL----------LGPYWFNVDSYSAIXXXXXXXXXXXXVSSVNVIPLIAD 470
+LL G +W V A + ++ D
Sbjct: 303 HRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGAL-------IFQVLMD 355
Query: 471 VTGMAHFPAGLGYNNIWNGSTAVVAEIFALKLRD 504
+ M FP LG + +G +++ A L D
Sbjct: 356 IVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLD 389
>YOL119c [G] KOG2504 Monocarboxylate transporter
Length = 501
Score = 63.9 bits (154), Expect = 6e-10
Identities = 51/272 (18%), Positives = 103/272 (37%), Gaps = 6/272 (2%)
Query: 171 YLSSNYFPNATPTDFAVIXXXXXXXXXXXXXXSAMCMNKFGYRPVMLVGVLLQXXXXXXX 230
Y+S + N + + + I S ++ G +M G ++
Sbjct: 123 YISKHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFAL 182
Query: 231 XXXXXXGELYFTYGILLGFANGFIFGCNSVVIPGWFLKKRAFANGLTHIGVGLGGLVLTF 290
+ + + G G + + WFLK+R A ++ +G +GG+V
Sbjct: 183 ANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPI 242
Query: 291 AVHAIMEKTGSHKWPMRFLGIMVLVFNTIAALIVKIRVPRNPPPQKSSLQLLK----DVY 346
+ + ++ G +W +R L + L A+++ + R P KS ++ K V+
Sbjct: 243 MLRKLYKEVG-FQWAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEVAKWYISSVF 301
Query: 347 DFNVYKLTPLQYCTLWSTMTNIGYVILLFSLSNYALSIGLNSQQATVTLALFNGAQIIGR 406
++ + + + ++ L++Y+++ G A + N I+GR
Sbjct: 302 NWRYFLEGKFLFVAIGASFAESSLTSCATYLASYSMTRGNTENVAYTMITASNAVGILGR 361
Query: 407 PAMGYFSEK-IGRVNCTSICMFYTILLLGPYW 437
GYF++K IGR N I + L W
Sbjct: 362 YIPGYFADKFIGRFNVEIITISMAALFNFVMW 393
>7292012 [G] KOG2504 Monocarboxylate transporter
Length = 816
Score = 63.9 bits (154), Expect = 6e-10
Identities = 52/208 (25%), Positives = 81/208 (38%), Gaps = 8/208 (3%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GGYGW+ C + N G +G+FL +++ YF T V
Sbjct: 74 GGYGWVICFASFMCNMIVDGIAYTFGIFLEEFVA--YFHEGKGTVAWVGSLLSGVYLSAG 131
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
SA+ NK+G R V + G ++ L TYG + GF G I+
Sbjct: 132 PIVSALA-NKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAV 190
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVFNTI 319
V + +F KR+ A G+ G G G ++E+ G W L L+ N
Sbjct: 191 VAVGYYFETKRSLATGIAVCGSGFGTFAFAPLATYLLEEYG---WKNALLIFAGLILN-- 245
Query: 320 AALIVKIRVPRNPPPQKSSLQLLKDVYD 347
A+ + P P +K L++ +Y+
Sbjct: 246 CAIFGAMMRPLTYPKKKKQKPLMQRMYE 273
>Hs7019529 [G] KOG2504 Monocarboxylate transporter
Length = 504
Score = 61.2 bits (147), Expect = 4e-09
Identities = 74/301 (24%), Positives = 116/301 (37%), Gaps = 38/301 (12%)
Query: 140 GGYGWICC-ACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXX 198
GG+GW+ AC VV F P F + L ++ +A +D A +
Sbjct: 15 GGWGWVVLGACFVVTGFAYGFPKAVSVFFRA--LMRDF--DAGYSDTAWVSSIMLAMLYG 70
Query: 199 XXXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCN 258
S++ + +FG RPVML G LL ELY T G+L G F +
Sbjct: 71 TGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPS 130
Query: 259 SVVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVFNT 318
+++ +F ++R ANGL G + L+ ++E+ G W FL + L+ +
Sbjct: 131 LIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFG---WRGGFLLLGGLLLHC 187
Query: 319 IAALIVKIRVPRNPPPQK--------------------SSLQLLK-DVYDFNVYKLTPLQ 357
A V +R P P P+ + LQL + + +L L
Sbjct: 188 CACGAV-MRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPWVRPRRRLLDLA 246
Query: 358 YCT--------LWSTMTNIGYVILLFSLSNYALSIGLNSQQATVTLALFNGAQIIGRPAM 409
CT + + +G + L NYA G+ A L++ I+ RPA
Sbjct: 247 VCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPAC 306
Query: 410 G 410
G
Sbjct: 307 G 307
>CE21446 [G] KOG2504 Monocarboxylate transporter
Length = 666
Score = 57.4 bits (137), Expect = 6e-08
Identities = 40/150 (26%), Positives = 63/150 (41%), Gaps = 3/150 (2%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GGYGW+ A ++N G G L + + +T AVI
Sbjct: 42 GGYGWVVVAASFLVNMAVDGVIYTCGKILVPIWADQF--GSTSVAGAVISILTGCYYLAG 99
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
S+ +N FG R V + G +L ELY +G+L G G ++ +
Sbjct: 100 PLASSF-VNVFGIRSVAIAGSILATTAFLLSRFASTIWELYLLFGVLGGIGFGCMYLPSI 158
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLT 289
V++ +F KKR+ A G+ G G+G +V +
Sbjct: 159 VILSTYFAKKRSVATGIAVCGSGIGTMVFS 188
>CE20478 [G] KOG2504 Monocarboxylate transporter
Length = 571
Score = 57.4 bits (137), Expect = 6e-08
Identities = 40/150 (26%), Positives = 63/150 (41%), Gaps = 3/150 (2%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GGYGW+ A ++N G G L + + +T AVI
Sbjct: 42 GGYGWVVVAASFLVNMAVDGVIYTCGKILVPIWADQF--GSTSVAGAVISILTGCYYLAG 99
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
S+ +N FG R V + G +L ELY +G+L G G ++ +
Sbjct: 100 PLASSF-VNVFGIRSVAIAGSILATTAFLLSRFASTIWELYLLFGVLGGIGFGCMYLPSI 158
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLT 289
V++ +F KKR+ A G+ G G+G +V +
Sbjct: 159 VILSTYFAKKRSVATGIAVCGSGIGTMVFS 188
>7295764 [G] KOG2504 Monocarboxylate transporter
Length = 1131
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/229 (21%), Positives = 94/229 (40%), Gaps = 12/229 (5%)
Query: 118 SIPEIEDDGLYNAXXXXXXXXXGGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYF 177
+IP + G+ GG+GWI C +++ T G YG L ++ + Y
Sbjct: 391 NIPALRRTGVDTTRIRQYFYPDGGWGWIICGVSFLVHILTTGLQLSYG--LLWFYAVQYL 448
Query: 178 PNATPTDFAVIXXXXXXXXXXXXXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXG 237
N + + S +C K R + +VG L+ G
Sbjct: 449 HNTSGIELLGALSWSVSMVATSFVVS-LC-RKRSIRLLSIVGGLVMPLGILFTSFATEFG 506
Query: 238 ELYFTYGILLGFANGFIFGCNSVVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIME 297
++ F+YGI+ G + ++V++ +F ++R F + G G+G A+ +++
Sbjct: 507 QVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVG-----IALFSVIL 561
Query: 298 KTGSHKWPMRFLGIMVLVFNTIAALIVKI--RVPRNPPPQKSSLQLLKD 344
K G K R LG+ ++ T + + + R PQ+ ++Q LK+
Sbjct: 562 KEGVGKAGWR-LGLQIVAALTALSFFMGLMYRPASLYHPQRRAIQHLKN 609
>Hs4759118 [G] KOG2504 Monocarboxylate transporter
Length = 523
Score = 55.1 bits (131), Expect = 3e-07
Identities = 43/195 (22%), Positives = 79/195 (40%), Gaps = 6/195 (3%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GG+GW + T+G +GVF + + S N + + + I
Sbjct: 21 GGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSF---NESNSRISWIISICVFVLTFS 77
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
+ + N+FG+R V+++G LL +Y GI+ G F F
Sbjct: 78 APLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTV 137
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVFNTI 319
++ +F K+R+ + G A+ A+ E+ G ++ + F+G++ L
Sbjct: 138 TILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIG-WRYSLLFVGLLQLNIVIF 196
Query: 320 AALI--VKIRVPRNP 332
AL+ + IR P +P
Sbjct: 197 GALLRPIIIRGPASP 211
>Hs20559959 [G] KOG2504 Monocarboxylate transporter
Length = 426
Score = 55.1 bits (131), Expect = 3e-07
Identities = 65/295 (22%), Positives = 110/295 (37%), Gaps = 17/295 (5%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GG+GW+ + +G +GVF ++++ F +
Sbjct: 10 GGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAA--FEEQAARVSWIASIGIAVQQFGS 67
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
SA+ KFG RPV++ G +L LY + G+L G F
Sbjct: 68 PVGSALS-TKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTL 126
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVFNTI 319
+ +F ++R+ A GL GVGL TFA + W L + L + +
Sbjct: 127 ACLSCYFSRRRSLATGLALTGVGLSS--FTFAPF-FQWLLSHYAWRGSLLLVSALSLHLV 183
Query: 320 A--ALIVKIRVPRNPPPQKSSLQLLKDVYDFNVYKLTPLQYCTLWSTMTNIGYVILLFSL 377
A AL+ + +P QL ++ P T+ T+ N GY I L
Sbjct: 184 ACGALLRPPSLAEDPAVGGPRAQLTSLLHH------GPFLRYTVALTLINTGYFIPYLHL 237
Query: 378 SNYALSIGLNSQQATVTLALFNGAQIIGRPAMGYFSEKI-GRVNCTSICMFYTIL 431
+ + + A L++ + ++GR G+ + + G V T + M +T L
Sbjct: 238 VAHLQDLDWDPLPAAFLLSVVAISDLVGRVVSGWLGDAVPGPV--TRLLMLWTTL 290
>7303156 [G] KOG2504 Monocarboxylate transporter
Length = 835
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/184 (20%), Positives = 70/184 (37%), Gaps = 3/184 (1%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GG+GW+ + G GV L + + + + +
Sbjct: 301 GGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDL---DVSISSVSFVASVQIGCYFTS 357
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
SA+ +N+FG+R V + GVL L F Y +L G I+ +
Sbjct: 358 GAFSAVLINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLGGITLSMIWASSQ 417
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVFNTI 319
+++ +F + R ANG + G G G ++ TF ++ G G+++L+ +
Sbjct: 418 LIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMV 477
Query: 320 AALI 323
A +
Sbjct: 478 VAYV 481
>7290288 [G] KOG2504 Monocarboxylate transporter
Length = 715
Score = 51.2 bits (121), Expect = 4e-06
Identities = 51/209 (24%), Positives = 83/209 (39%), Gaps = 11/209 (5%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GG+GW+ +++ T G +G+F + +L +YF N A I
Sbjct: 120 GGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFL--DYF-NEGKGYTAWIASIMVGVTFSS 176
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
S+ +N++G R V + G +L L T G G G I+
Sbjct: 177 GPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAI 236
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVLVFNTI 319
V + +F KR+ A G+ G G G V ++ G++ W L I +V N I
Sbjct: 237 VSVTQYFEAKRSLATGIAVCGSGFGTFVFAPLTEFLI---GNYGWRGAMLIIGGIVLNCI 293
Query: 320 --AALIVKIRV---PRNPPPQKSSLQLLK 343
A+ + + P+ PP S+ +L K
Sbjct: 294 IFGAMFRPLELEAPPQTPPNTPSTPKLAK 322
>7303008 [G] KOG2504 Monocarboxylate transporter
Length = 471
Score = 50.8 bits (120), Expect = 5e-06
Identities = 49/219 (22%), Positives = 82/219 (37%), Gaps = 10/219 (4%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GGYGWI A V ++N + +G L T A+I
Sbjct: 12 GGYGWIVVAAVALINMTNQSILSVFGQLFVGELQKMQEDTFTA---ALITNLNSLALNFS 68
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
+ F R V G +L Y +GF G I
Sbjct: 69 GLFIGPAIKSFKPRNVAATGCILVALGLALCAFASESWHFILGYSFFVGFGLGLISPSTF 128
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTGSHKWPMRFLGIMVL-VFNT 318
+ I +F KR A G++ G GLG +++ V +++ +H + L + L +F
Sbjct: 129 MAINSYFTTKRGRAVGVSLAGAGLGQVLIPHLVRYLLD---NHGFRYAVLSMSSLSLFGL 185
Query: 319 IAALIVKIRVPRNPPPQKSSLQLLKDVYDFNVYKLTPLQ 357
A +K P NPP + ++ + ++ + + + K +PLQ
Sbjct: 186 FGAAFLK---PLNPPAKHNNRKHIRLLTEADGEKTSPLQ 221
>7302291 [G] KOG2504 Monocarboxylate transporter
Length = 800
Score = 50.8 bits (120), Expect = 5e-06
Identities = 40/161 (24%), Positives = 65/161 (39%), Gaps = 3/161 (1%)
Query: 140 GGYGWICCACVVVMNFCTWGPNTCYGVFLSYYLSSNYFPNATPTDFAVIXXXXXXXXXXX 199
GGYGW+ +V++ G + +G+ L YF +T + A I
Sbjct: 41 GGYGWVVVFASLVVSLIADGLSFSFGLINVELLE--YFGEST-SKTAWISSLFFSVPLLM 97
Query: 200 XXXSAMCMNKFGYRPVMLVGVLLQXXXXXXXXXXXXXGELYFTYGILLGFANGFIFGCNS 259
+ ++K+G R + ++G ++ L T+GI+ G G +
Sbjct: 98 GPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAV 157
Query: 260 VVIPGWFLKKRAFANGLTHIGVGLGGLVLTFAVHAIMEKTG 300
V I WF KKR FA G+ G G+G V ++E G
Sbjct: 158 VSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYG 198
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.325 0.142 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,580,322
Number of Sequences: 60738
Number of extensions: 1253032
Number of successful extensions: 3448
Number of sequences better than 1.0e-05: 18
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3416
Number of HSP's gapped (non-prelim): 23
length of query: 579
length of database: 30,389,216
effective HSP length: 112
effective length of query: 467
effective length of database: 23,586,560
effective search space: 11014923520
effective search space used: 11014923520
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)