ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI3080 good H KOG2872 Coenzyme transport and metabolism Uroporphyrinogen decarboxylase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI3080 1086389 1087495 369
(369 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR047w [H] KOG2872 Uroporphyrinogen decarboxylase 625 e-179
SPCC4B3.05c [H] KOG2872 Uroporphyrinogen decarboxylase 407 e-113
Hs9845522 [H] KOG2872 Uroporphyrinogen decarboxylase 367 e-101
Hs14742907 [H] KOG2872 Uroporphyrinogen decarboxylase 365 e-101
7303877 [H] KOG2872 Uroporphyrinogen decarboxylase 320 2e-87
At2g40490 [H] KOG2872 Uroporphyrinogen decarboxylase 221 1e-57
At3g14930 [H] KOG2872 Uroporphyrinogen decarboxylase 171 1e-42
>YDR047w [H] KOG2872 Uroporphyrinogen decarboxylase
Length = 362
Score = 625 bits (1611), Expect = e-179
Identities = 296/359 (82%), Positives = 325/359 (90%)
Query: 11 FAPMKNDLMLRAALGEKVERPPCWIMRQAGRYLPEYHEVKNGRDFFETCRDAEIASEITI 70
F KNDL+LRAA GEKVERPPCWIMRQAGRYLPEYHEVKN RDFF+TCRDAEIASEITI
Sbjct: 4 FPAPKNDLILRAAKGEKVERPPCWIMRQAGRYLPEYHEVKNNRDFFQTCRDAEIASEITI 63
Query: 71 QPVRRYAGLLDAAIIFSDILVIPQAMGMKVEMVEGKGPHFPEPLRTEEQLQKVLDYKVNV 130
QPVRRY GL+DAAIIFSDILVIPQAMGM+VEM+EGKGPHFPEPLR E LQ VLDYKV+V
Sbjct: 64 QPVRRYRGLIDAAIIFSDILVIPQAMGMRVEMLEGKGPHFPEPLRNPEDLQTVLDYKVDV 123
Query: 131 LDELEWAFKAITMTRTKLDGQVPLLGFCGAPWTLLVYMTEGGGSRLFRFAKQWLNESPES 190
L EL+WAFKAITMTR KLDG+VPL GFCG PWTL+VYMTEGGGSRLFRFAKQW+N PE
Sbjct: 124 LKELDWAFKAITMTRIKLDGEVPLFGFCGGPWTLMVYMTEGGGSRLFRFAKQWINMYPEL 183
Query: 191 SHKLLQKITDVAVEFLCQQVVAGCQMLQVFESWGGELGSRDFDEFSLPYLKQIAERVPPR 250
SHKLLQKITDVAVEFL QQVVAG Q+LQVFESWGGEL S DFDEFSLPYL+QIAERVP R
Sbjct: 184 SHKLLQKITDVAVEFLSQQVVAGAQILQVFESWGGELSSVDFDEFSLPYLRQIAERVPKR 243
Query: 251 LKQLGIEERVPMVVFAKGSWYALDKLCDSGYNAVSLDWSWDPAEAVKINSDRVTLQGNLD 310
L++LGI E++PM+VFAKGSWYALDKLC SG++ VSLDWSWDP EAVKIN +RVTLQGNLD
Sbjct: 244 LQELGIMEQIPMIVFAKGSWYALDKLCCSGFDVVSLDWSWDPREAVKINKNRVTLQGNLD 303
Query: 311 PGVIYGSDEIITKRVTEMVHGFGGGKQHYIVNFGHGTHPFMDPEKIKFFLQECHRVGSQ 369
PGV+YGS E+ITK+V +M+ FGGGK YIVNFGHGTHPFMDP+ IKFFL+ECHR+GS+
Sbjct: 304 PGVMYGSKEVITKKVKQMIEAFGGGKSRYIVNFGHGTHPFMDPDVIKFFLEECHRIGSK 362
>SPCC4B3.05c [H] KOG2872 Uroporphyrinogen decarboxylase
Length = 370
Score = 407 bits (1045), Expect = e-113
Identities = 202/371 (54%), Positives = 264/371 (70%), Gaps = 18/371 (4%)
Query: 14 MKNDLMLRAALGEKVERPPCWIMRQ---AGRYLP------------EYHEVKNGRDFFET 58
MKNDL+LRAA GE+VERPP WIM + Y+ EYH+++ + FFE
Sbjct: 1 MKNDLILRAAKGEEVERPPVWIMASWKISSWYVHDLNLIVCTNETIEYHKLRAKQSFFEM 60
Query: 59 CRDAEIASEITIQPVRRYAGLLDAAIIFSDILVIPQAMGMKVEMVEGKGPHFPEPLRTEE 118
C+ E A E+T+QPV R+ GLLDAAIIFSDILVIPQA+GM+V M+E KGPHFP+PL E
Sbjct: 61 CQTPETACELTLQPVTRFKGLLDAAIIFSDILVIPQALGMQVVMLEQKGPHFPKPLVVPE 120
Query: 119 QLQKVLDYKVNVLDELEWAFKAITMTRTKLDGQVPLLGFCGAPWTLLVYMTEGGGSRLFR 178
+ +L+ N+ +L + AI++TR KLDGQVPL+GF GAPWT++ YM EGGGS+ F
Sbjct: 121 DID-LLEKTPNISAKLGYVMDAISLTREKLDGQVPLMGFSGAPWTIMAYMIEGGGSKTFA 179
Query: 179 FAKQWLNESPESSHKLLQKITDVAVEFLCQQVVAGCQMLQVFESWGGELGSRDFDEFSLP 238
AK WL PE+SHKLL+ ITD V +L QQV AG Q+LQ+F+SW GEL DF E++ P
Sbjct: 180 KAKSWLFRYPEASHKLLKIITDATVSYLIQQVYAGAQLLQIFDSWAGELSPEDFTEYAYP 239
Query: 239 YLKQIAERVPPRLKQLGIEERVPMVVFAKGSWYALDKLCDSGYNAVSLDWSWDPAEAVKI 298
YL +I + V LK+ +E VPM+VFAKG+WYA+D+LCDSGY+ + LDW+ P EAV+I
Sbjct: 240 YLVRICQEVKQHLKKKKRDE-VPMIVFAKGAWYAIDQLCDSGYDVIGLDWTVSPKEAVRI 298
Query: 299 NSD-RVTLQGNLDPGVIYGSDEIITKRVTEMVHGFGGGKQHYIVNFGHGTHPFMDPEKIK 357
+ RVT QGNLDP ++YG+ EII R EM+ FGGGKQ YI+N GHG P ++P+ ++
Sbjct: 299 RGNRRVTFQGNLDPNILYGTREIIEARTKEMIQDFGGGKQGYIINLGHGITPGVNPDDVR 358
Query: 358 FFLQECHRVGS 368
FFL++CH+ GS
Sbjct: 359 FFLEKCHQYGS 369
>Hs9845522 [H] KOG2872 Uroporphyrinogen decarboxylase
Length = 367
Score = 367 bits (943), Expect = e-101
Identities = 185/365 (50%), Positives = 251/365 (68%), Gaps = 6/365 (1%)
Query: 1 MQVQNVDRSKFAPMKNDLMLRAALGEKVERPPCWIMRQAGRYLPEYHEVKNGRDFFETCR 60
M+ + F +KND LRAA GE+ + P W MRQAGRYLPE+ E + +DFF TCR
Sbjct: 1 MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCR 60
Query: 61 DAEIASEITIQPVRRYAGLLDAAIIFSDILVIPQAMGMKVEMVEGKGPHFPEPLRTEEQL 120
E E+T+QP+RR+ LLDAAIIFSDILV+PQA+GM+V MV GKGP FPEPLR E+ L
Sbjct: 61 SPEACCELTLQPLRRF--LLDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDL 118
Query: 121 QKVLDYKVNVLDELEWAFKAITMTRTKLDGQVPLLGFCGAPWTLLVYMTEGGGSRLFRFA 180
+++ D +V V EL + F+AIT+TR +L G+VPL+GF GAPWTL+ YM EGGGS A
Sbjct: 119 ERLRDPEV-VASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQA 177
Query: 181 KQWLNESPESSHKLLQKITDVAVEFLCQQVVAGCQMLQVFESWGGELGSRDFDEFSLPYL 240
K+WL + P++SH+LL+ +TD V +L QVVAG Q LQ+FES G LG + F++F+LPY+
Sbjct: 178 KRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYI 237
Query: 241 KQIAERVPPRLKQLGIEERVPMVVFAKGSWYALDKLCDSGYNAVSLDWSWDPAEAVKINS 300
+ +A++V RL++ G+ VPM++FAK +AL++L +GY V LDW+ P +A +
Sbjct: 238 RDVAKQVKARLREAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVG 296
Query: 301 DRVTLQGNLDPGVIYGSDEIITKRVTEMVHGFGGGKQHYIVNFGHGTHPFMDPEKIKFFL 360
VTLQGNLDP +Y S+E I + V +M+ F G YI N GHG +P MDPE + F+
Sbjct: 297 KTVTLQGNLDPCALYASEEEIGQLVKQMLDDF--GPHRYIANLGHGLYPDMDPEHVGAFV 354
Query: 361 QECHR 365
H+
Sbjct: 355 DAVHK 359
>Hs14742907 [H] KOG2872 Uroporphyrinogen decarboxylase
Length = 367
Score = 365 bits (938), Expect = e-101
Identities = 184/365 (50%), Positives = 250/365 (68%), Gaps = 6/365 (1%)
Query: 1 MQVQNVDRSKFAPMKNDLMLRAALGEKVERPPCWIMRQAGRYLPEYHEVKNGRDFFETCR 60
M+ + F +KND LRAA GE+ + P W MRQAGRYLPE+ E + +DFF TCR
Sbjct: 1 MEANGLGPQGFPELKNDTFLRAAWGEETDYTPVWCMRQAGRYLPEFRETRAAQDFFSTCR 60
Query: 61 DAEIASEITIQPVRRYAGLLDAAIIFSDILVIPQAMGMKVEMVEGKGPHFPEPLRTEEQL 120
E E+T+QP+RR+ LDAAIIFSDILV+PQA+GM+V MV GKGP FPEPLR E+ L
Sbjct: 61 SPEACCELTLQPLRRFP--LDAAIIFSDILVVPQALGMEVTMVPGKGPSFPEPLREEQDL 118
Query: 121 QKVLDYKVNVLDELEWAFKAITMTRTKLDGQVPLLGFCGAPWTLLVYMTEGGGSRLFRFA 180
+++ D +V V EL + F+AIT+TR +L G+VPL+GF GAPWTL+ YM EGGGS A
Sbjct: 119 ERLRDPEV-VASELGYVFQAITLTRQRLAGRVPLIGFAGAPWTLMTYMVEGGGSSTMAQA 177
Query: 181 KQWLNESPESSHKLLQKITDVAVEFLCQQVVAGCQMLQVFESWGGELGSRDFDEFSLPYL 240
K+WL + P++SH+LL+ +TD V +L QVVAG Q LQ+FES G LG + F++F+LPY+
Sbjct: 178 KRWLYQRPQASHQLLRILTDALVPYLVGQVVAGAQALQLFESHAGHLGPQLFNKFALPYI 237
Query: 241 KQIAERVPPRLKQLGIEERVPMVVFAKGSWYALDKLCDSGYNAVSLDWSWDPAEAVKINS 300
+ +A++V RL++ G+ VPM++FAK +AL++L +GY V LDW+ P +A +
Sbjct: 238 RDVAKQVKARLREAGLAP-VPMIIFAKDGHFALEELAQAGYEVVGLDWTVAPKKARECVG 296
Query: 301 DRVTLQGNLDPGVIYGSDEIITKRVTEMVHGFGGGKQHYIVNFGHGTHPFMDPEKIKFFL 360
VTLQGNLDP +Y S+E I + V +M+ F G YI N GHG +P MDPE + F+
Sbjct: 297 KTVTLQGNLDPCALYASEEEIGQLVKQMLDDF--GPHRYIANLGHGLYPDMDPEHVGAFV 354
Query: 361 QECHR 365
H+
Sbjct: 355 DAVHK 359
>7303877 [H] KOG2872 Uroporphyrinogen decarboxylase
Length = 356
Score = 320 bits (821), Expect = 2e-87
Identities = 171/359 (47%), Positives = 226/359 (62%), Gaps = 7/359 (1%)
Query: 7 DRSKFAPMKNDLMLRAALGEKVERPPCWIMRQAGRYLPEYHEVKNGRDFFETCRDAEIAS 66
D F +KND +LRAA GE V+R P W+MRQAGRYLPE+ E++ DFF CR E+A
Sbjct: 3 DAKPFPVLKNDNLLRAARGEVVDRVPVWVMRQAGRYLPEFQELRKHHDFFTVCRTPELAC 62
Query: 67 EITIQPVRRYAGLLDAAIIFSDILVIPQAMGMKVEMVEGKGPHFPEPLRTEEQLQKVLDY 126
E+T+QP+RR+ LDA+IIFSDILVIPQA+G+ VEM G GP P+P+ E L+++
Sbjct: 63 EVTMQPLRRFD--LDASIIFSDILVIPQALGLTVEMHAGVGPVLPQPIVVPEDLKRLTPD 120
Query: 127 KVNVLDELEWAFKAITMTRTKLDGQVPLLGFCGAPWTLLVYMTEGGGSRLFRFAKQWLNE 186
L L + AITM R KL+G+VPL+GF GAPWTL+ YM EGGGS+ AK WLNE
Sbjct: 121 --GALSRLSYVGDAITMMRHKLEGRVPLIGFTGAPWTLMGYMIEGGGSKTMSKAKAWLNE 178
Query: 187 SPESSHKLLQKITDVAVEFLCQQVVAGCQMLQVFESWGGELGSRDFDEFSLPYLKQIAER 246
PE S L +TD V++L QV AG QMLQVFES L F ++ +PYLK+I +
Sbjct: 179 HPEDSKLFLNLLTDAIVDYLEMQVKAGAQMLQVFESSAEHLSKEQFLQWCVPYLKRIRDE 238
Query: 247 VPPRLKQLGIEERVPMVVFAKGSWYALDKLCDSGYNAVSLDWSWDPAEAVKINSDRVTLQ 306
+ RL + I VPM +FAKG+ ++L + + GY+ + LDW+ DP EA + +TLQ
Sbjct: 239 LVDRLTKKAIPV-VPMTLFAKGAGHSLKEQSELGYDVIGLDWTVDPLEARNLVGPNITLQ 297
Query: 307 GNLDPGVIYGSDEIITKRVTEMVHGFGGGKQHYIVNFGHGTHPFMDPEKIKFFLQECHR 365
GNLDP +Y + + TEMVH F GK YI N GHG P ++ ++ H+
Sbjct: 298 GNLDPQDMYRDPDELRNLTTEMVHKF--GKSRYIANLGHGITPQTPITSMEVLVEAVHK 354
>At2g40490 [H] KOG2872 Uroporphyrinogen decarboxylase
Length = 394
Score = 221 bits (563), Expect = 1e-57
Identities = 128/362 (35%), Positives = 200/362 (54%), Gaps = 13/362 (3%)
Query: 6 VDRSKFAPMKNDLMLRAALGEKVERPPCWIMRQAGRYLPEYHEV-KNGRDFFETCRDAEI 64
V K + L+LRA GE V+RPP W+MRQAGRY+ Y + + F + +A++
Sbjct: 43 VTERKVSATSEPLLLRAVKGEVVDRPPVWLMRQAGRYMKSYQTLCEKYPSFRDRSENADL 102
Query: 65 ASEITIQPVRRYAGLLDAAIIFSDILVIPQAMGMKVEMVEGKGPHFPEPLRTEEQLQKVL 124
EI++QP + + D I+FSDIL M + ++V+GKGP P ++ + +V
Sbjct: 103 VVEISLQPWKVFKP--DGVILFSDILTPLSGMNIPFDIVKGKGPIIFNPPQSAADVAQVR 160
Query: 125 DYKVNVLDELEWAFKAITMTRTKLDGQVPLLGFCGAPWTLLVYMTEGGGSRLFRFAKQWL 184
++ + + + +A+ R +++ + +LGF GAP+TL Y+ EGG S+ F K+
Sbjct: 161 EFVPE--ESVPYVGEALRRLRNEVNNEAAVLGFVGAPFTLSSYVIEGGSSKNFTQIKRLA 218
Query: 185 NESPESSHKLLQKITDVAVEFLCQQVVAGCQMLQVFESWGGELGSRDFDEFSLPYLKQIA 244
P+ H LLQK T + ++ Q +G Q +Q+F+SW EL DF+EFSLPYLKQI
Sbjct: 219 FSQPKVLHALLQKFTTSMITYIRYQADSGAQAVQIFDSWATELSPVDFEEFSLPYLKQIV 278
Query: 245 ERVPPRLKQLGIEERVPMVVFAKGSWYALDKLCDSGYNAVSLDWSWDPAEAVKINSDRVT 304
E V KQ +P++++A GS L++L +G + VSLDW+ D AE +
Sbjct: 279 EAV----KQ--THPNLPLILYASGSGGLLERLARTGVDVVSLDWTVDMAEGRDRLGRDIA 332
Query: 305 LQGNLDPGVIYGSDEIITKRVTEMVHGFGGGKQHYIVNFGHGTHPFMDPEKIKFFLQECH 364
+QGN+DPGV++GS E IT R+ + V G+ +I+N GHG E + F +
Sbjct: 333 VQGNVDPGVLFGSKEFITSRIHDTVK--KAGRDKHILNLGHGIKVGTPEENVAHFFEVAQ 390
Query: 365 RV 366
+
Sbjct: 391 EI 392
>At3g14930 [H] KOG2872 Uroporphyrinogen decarboxylase
Length = 341
Score = 171 bits (434), Expect = 1e-42
Identities = 99/338 (29%), Positives = 177/338 (52%), Gaps = 18/338 (5%)
Query: 35 IMRQAGRYLPEYHEV-KNGRDFFETCRDAEIASEITIQPVRRYAGLLDAAIIFSDILVIP 93
+MRQAGRY+ Y ++ K F E + ++ EI++QP + + D IIFSDIL
Sbjct: 1 MMRQAGRYMAVYQKLAKKHPSFRERSENTDLIVEISLQPWQAFRP--DGVIIFSDILTPL 58
Query: 94 QAMGMKVEMVEGKGPHFPEPLRTEEQLQKV--LDYKVNVLDELEWAFKAITMTRTKLDGQ 151
A G+ ++ E KGP P+RTEE ++++ +D+ ++L++ ++ + R ++
Sbjct: 59 PAFGVPFDIEEVKGPVIQSPIRTEEDMKRLHPIDF-----EKLQFVGDSLKILRREVGEH 113
Query: 152 VPLLGFCGAPWTLLVYMTEGGGSRLFRFAKQWLNESPESSHKLLQKITDVAVEFLCQQVV 211
+LGF GAPWT+ Y+ EGG +R + K + +P+ LL +T E++ QV
Sbjct: 114 AAVLGFVGAPWTIATYIVEGGTTRTYTVIKNMCHTAPDVLRALLSHLTKAITEYVVYQVE 173
Query: 212 AGCQMLQVFESWGGELGSRDFDEFSLPYLKQIAERVPPRLKQLGIEERVPMVVFAKGSWY 271
G +Q+F+SWGG+L ++ +S PY+++I V R P+V + G+
Sbjct: 174 HGAHCIQIFDSWGGQLTPEMWERWSKPYIEEIIHAVKKRCPD------TPIVFYINGNGG 227
Query: 272 ALDKLCDSGYNAVSLDWSWDPAEAVKINSDRVTLQGNLDPGVIYGSDEIITKRVTEMVHG 331
L+++ +G + + LDW+ D A+ + V++QGN+DP ++ +T+ + +V
Sbjct: 228 LLERMKGTGADVIGLDWTVDMADGRRRLGSEVSVQGNVDPAYLFSPLPALTEEIERVVK- 286
Query: 332 FGGGKQHYIVNFGHGTHPFMDPEKIKFFLQECHRVGSQ 369
G + +I+N GHG E + F + + Q
Sbjct: 287 -CAGPKGHILNLGHGVLVGTPEEAVAHFFETARNLDYQ 323
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.322 0.139 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,381,881
Number of Sequences: 60738
Number of extensions: 1014521
Number of successful extensions: 2164
Number of sequences better than 1.0e-05: 7
Number of HSP's better than 0.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 2133
Number of HSP's gapped (non-prelim): 7
length of query: 369
length of database: 30,389,216
effective HSP length: 108
effective length of query: 261
effective length of database: 23,829,512
effective search space: 6219502632
effective search space used: 6219502632
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)