ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI3239 good C KOG1526 Energy production and conversion NADP-dependent isocitrate dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI3239 1137608 1138852 415
(415 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR174w [C] KOG1526 NADP-dependent isocitrate dehydrogenase 666 0.0
YNL009w [C] KOG1526 NADP-dependent isocitrate dehydrogenase 616 e-176
YDL066w [C] KOG1526 NADP-dependent isocitrate dehydrogenase 607 e-174
At5g14590 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 532 e-151
At1g65930 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 529 e-150
At1g54340 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 523 e-148
SPAC6G10.08 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 512 e-145
Hs4504575 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 510 e-144
Hs14729950 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 510 e-144
Hs5174471 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 507 e-143
CE03436 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 501 e-142
CE15677 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 494 e-140
7295108 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 494 e-139
Hs17463070 [C] KOG1526 NADP-dependent isocitrate dehydrogenase 392 e-109
>YLR174w [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 412
Score = 666 bits (1718), Expect = 0.0
Identities = 329/413 (79%), Positives = 370/413 (88%), Gaps = 3/413 (0%)
Query: 1 MSKISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQS 60
M+KI V PIVEMDGDEQTRIIW LI+D L+ PYLD+DLKYYDLS+E RD T+D+VT S
Sbjct: 1 MTKIKVANPIVEMDGDEQTRIIWHLIRDKLVLPYLDVDLKYYDLSVEYRDQTNDQVTVDS 60
Query: 61 AQATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKL 120
A ATLKYGVAVKCATITPDEARVEEF LKKMWKSPNGTIRNILGGTVFREPI+IPRIP+L
Sbjct: 61 ATATLKYGVAVKCATITPDEARVEEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRL 120
Query: 121 VTNWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGG 180
V WEKPIIIGRHAFGDQY+ATDV++P G+L+LV++S S T +++L V+D+ E GG
Sbjct: 121 VPQWEKPIIIGRHAFGDQYKATDVIVPEEGELRLVYKSK-SGTHDVDLKVFDYPEH--GG 177
Query: 181 VAMAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKS 240
VAM MYNT +SI GFA ASF++A+ER LPLYSTTKNTILKKYDGKFKDVFE++Y YK
Sbjct: 178 VAMMMYNTTDSIEGFAKASFELAIERKLPLYSTTKNTILKKYDGKFKDVFEAMYARSYKE 237
Query: 241 AFEAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLIT 300
FE+ GIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLIT
Sbjct: 238 KFESLGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLIT 297
Query: 301 PDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAE 360
PDGK FESEAAHGTVTRH+RQHQQGKETSTNSIASIFAWTRG+IQRGKLD+TPDVVKF +
Sbjct: 298 PDGKTFESEAAHGTVTRHFRQHQQGKETSTNSIASIFAWTRGIIQRGKLDNTPDVVKFGQ 357
Query: 361 LVESATVNTVQEDEIMTKDLALILGKTDRSSYVTTEEFIEAVHKRLDSEFKSS 413
++ESATVNTVQED IMTKDLALILGK++RS+YVTTEEFI+AV RL EF+++
Sbjct: 358 ILESATVNTVQEDGIMTKDLALILGKSERSAYVTTEEFIDAVESRLKKEFEAA 410
>YNL009w [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 420
Score = 616 bits (1589), Expect = e-176
Identities = 307/413 (74%), Positives = 359/413 (86%), Gaps = 3/413 (0%)
Query: 1 MSKISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQS 60
MSKI V PIVEMDGDEQTR+IWKLIK+ LI PYLD+DLKYYDLSI+ RD T+D+VT+ S
Sbjct: 1 MSKIKVVHPIVEMDGDEQTRVIWKLIKEKLILPYLDVDLKYYDLSIQERDRTNDQVTKDS 60
Query: 61 AQATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKL 120
+ ATLKYGVAVKCATITPDEAR++EF LK+MWKSPNGTIRNILGGTVFREPI+IP+IP+L
Sbjct: 61 SYATLKYGVAVKCATITPDEARMKEFNLKEMWKSPNGTIRNILGGTVFREPIIIPKIPRL 120
Query: 121 VTNWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGG 180
V +WEKPIIIGRHAFGDQYRATD+ I AGKL+L F SDD ENI+L VY+F + GG
Sbjct: 121 VPHWEKPIIIGRHAFGDQYRATDIKIKKAGKLRLQFSSDDGK-ENIDLKVYEFPKS--GG 177
Query: 181 VAMAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKS 240
+AMAM+NT +SI GFA ASF++AL+R LPL+ TTKNTILK YD +FK +F++L++ +YK
Sbjct: 178 IAMAMFNTNDSIKGFAKASFELALKRKLPLFFTTKNTILKNYDNQFKQIFDNLFDKEYKE 237
Query: 241 AFEAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLIT 300
F+A I YEHRLIDDMVAQMLKSKGG+IIAMKNYDGDV+SDIVAQGFGSLGLMTS+LIT
Sbjct: 238 KFQALKITYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSILIT 297
Query: 301 PDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAE 360
PDGK FESEAAHGTVTRH+R+HQ+G+ETSTNSIASIFAWTR +IQRGKLD+T DV+KF
Sbjct: 298 PDGKTFESEAAHGTVTRHFRKHQRGEETSTNSIASIFAWTRAIIQRGKLDNTDDVIKFGN 357
Query: 361 LVESATVNTVQEDEIMTKDLALILGKTDRSSYVTTEEFIEAVHKRLDSEFKSS 413
L+E AT++TVQ MTKDLAL+LGKT+RSSYVTTEEFI+ V KRL + SS
Sbjct: 358 LLEKATLDTVQVGGKMTKDLALMLGKTNRSSYVTTEEFIDEVAKRLQNMMLSS 410
>YDL066w [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 428
Score = 607 bits (1566), Expect = e-174
Identities = 298/413 (72%), Positives = 354/413 (85%), Gaps = 6/413 (1%)
Query: 2 SKISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSA 61
SKI VK P+VE+DGDE TRIIW IK LI PYLD+DLKYYDLS+E+RD T DK+T+ +A
Sbjct: 18 SKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAA 77
Query: 62 QATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLV 121
+A KYGV +KCATITPDEARV+EF L KMWKSPNGTIRNILGGTVFREPIVIPRIP+LV
Sbjct: 78 EAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLV 137
Query: 122 TNWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIE-LSVYDFDEESKG- 179
WEKPIIIGRHA GDQY+ATD +IPG G L+LV++ D T + L VYD+ KG
Sbjct: 138 PRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDY----KGS 193
Query: 180 GVAMAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYK 239
GVAMAMYNT ESI GFAH+SFK+A+++ L L+ +TKNTILKKYDG+FKD+F+ +YE+QYK
Sbjct: 194 GVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYK 253
Query: 240 SAFEAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLI 299
S FE GI YEHRLIDDMVAQM+KSKGG+I+A+KNYDGDV+SDIVAQGFGSLGLMTS+L+
Sbjct: 254 SKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILV 313
Query: 300 TPDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFA 359
TPDGK FESEAAHGTVTRHYR++Q+G+ETSTNSIASIFAW+RGL++RG+LD+TP + KFA
Sbjct: 314 TPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFA 373
Query: 360 ELVESATVNTVQEDEIMTKDLALILGKTDRSSYVTTEEFIEAVHKRLDSEFKS 412
++ESAT+NTVQ+D IMTKDLAL G +RS+YVTTEEF++AV KRL E KS
Sbjct: 374 NILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKS 426
>At5g14590 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 465
Score = 532 bits (1371), Expect = e-151
Identities = 271/412 (65%), Positives = 324/412 (77%), Gaps = 11/412 (2%)
Query: 3 KISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSAQ 62
+I V+ PIVEMDGDE TR+IW +IK+ LI PYLD+D+KY+DL I NRD TDDKVT +SA+
Sbjct: 57 RIQVQNPIVEMDGDEMTRVIWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTVESAE 116
Query: 63 ATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLVT 122
A LKY VA+KCATITPDE RV+EF LK MW+SPNGTIRNIL GTVFREPI+ IP+LV
Sbjct: 117 AALKYNVAIKCATITPDEGRVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIPRLVP 176
Query: 123 NWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKG-GV 181
WEKPI IGRHAFGDQYRATD VI G GKLK+VFE D N +EL VYDF KG GV
Sbjct: 177 GWEKPICIGRHAFGDQYRATDTVIKGPGKLKMVFE--DGNAP-VELDVYDF----KGPGV 229
Query: 182 AMAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKSA 241
A+AMYN ESI FA +S MAL + PLY +TKNTILKKYDG+FKD+F+ +YE+ +K
Sbjct: 230 ALAMYNVDESIRAFAESSMAMALTKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKQK 289
Query: 242 FEAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITP 301
FE IWYEHRLIDDMVA +KS+GGY+ A KNYDGDV+SD++AQGFGSLGLMTSVL++
Sbjct: 290 FEEHSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDGDVQSDLLAQGFGSLGLMTSVLLSA 349
Query: 302 DGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAEL 361
DGK ESEAAHGTVTRH+R HQ+G+ETSTNSIASIFAWTRGL R KLD ++ F +
Sbjct: 350 DGKTLESEAAHGTVTRHFRLHQKGQETSTNSIASIFAWTRGLEHRAKLDKNEKLMDFVKK 409
Query: 362 VESATVNTVQEDEIMTKDLALIL--GKTDRSSYVTTEEFIEAVHKRLDSEFK 411
+ES+ VNTV+ + MTKDLAL++ K R ++ TEEFI+AV +L ++FK
Sbjct: 410 LESSCVNTVETGK-MTKDLALLIHGPKVSRDLFLNTEEFIDAVASKLKTQFK 460
>At1g65930 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 410
Score = 529 bits (1363), Expect = e-150
Identities = 267/406 (65%), Positives = 313/406 (76%), Gaps = 8/406 (1%)
Query: 3 KISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSAQ 62
KI V PIVEMDGDE TR+IWK IKD LI P++++D+KY+DL + +RD TDDKVT +SA+
Sbjct: 5 KIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESAE 64
Query: 63 ATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLVT 122
AT KY VA+KCATITPDE RV EF LK+MW+SPNGTIRNIL GTVFREPI+ +PKLV
Sbjct: 65 ATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLVP 124
Query: 123 NWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGGVA 182
W KPI IGRHAFGDQYRATD VI G GKL + FE D TE V+ F E GGVA
Sbjct: 125 GWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKTET---EVFTFTGE--GGVA 179
Query: 183 MAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKSAF 242
MAMYNT ESI FA AS A E+ PLY +TKNTILKKYDG+FKD+F+ +YE+ +KS +
Sbjct: 180 MAMYNTDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWKSKY 239
Query: 243 EAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPD 302
+A GIWYEHRLIDDMVA LKS+GGY+ A KNYDGDV+SD +AQGFGSLGLMTSVL+ PD
Sbjct: 240 DAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPD 299
Query: 303 GKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAELV 362
GK E+EAAHGTVTRH+R HQ+G ETSTNSIASIFAWTRGL R KLD ++ F E +
Sbjct: 300 GKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFTEKL 359
Query: 363 ESATVNTVQEDEIMTKDLALIL--GKTDRSSYVTTEEFIEAVHKRL 406
E+A V TV+ + MTKDLALI+ K R +Y+ TEEFI+AV L
Sbjct: 360 EAACVGTVESGK-MTKDLALIIHGSKLSRDTYLNTEEFIDAVAAEL 404
>At1g54340 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 416
Score = 523 bits (1348), Expect = e-148
Identities = 259/402 (64%), Positives = 317/402 (78%), Gaps = 7/402 (1%)
Query: 3 KISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSAQ 62
KI V P+VEMDGDE TR+IWK IKD LI P+L++D+KY+DL + NRD TDDKVT ++A+
Sbjct: 5 KIKVINPVVEMDGDEMTRVIWKFIKDKLIFPFLELDIKYFDLGLPNRDFTDDKVTIETAE 64
Query: 63 ATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLVT 122
ATLKY VA+KCATITPDEARV EF LKKMW+SPNGTIRNIL GTVFREPI+ IP+LV
Sbjct: 65 ATLKYNVAIKCATITPDEARVREFGLKKMWRSPNGTIRNILNGTVFREPIICRNIPRLVP 124
Query: 123 NWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGGVA 182
W KPI IGRHAFGDQYRATD+++ GKLKLVFE S+ + E V++F + GGVA
Sbjct: 125 GWTKPICIGRHAFGDQYRATDLIVNEPGKLKLVFEPSGSS-QKTEFEVFNF---TGGGVA 180
Query: 183 MAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKSAF 242
+AMYNT ESI FA +S A ++ PLY +TKNTILK YDG+FKD+F+ +YE+ ++S +
Sbjct: 181 LAMYNTDESIRAFAESSMYTAYQKKWPLYLSTKNTILKIYDGRFKDIFQEVYEANWRSKY 240
Query: 243 EAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPD 302
EA GIWYEHRLIDDMVA +KS+GGY+ A KNYDGDV+SD +AQG+GSLG+MTSVL+ PD
Sbjct: 241 EAAGIWYEHRLIDDMVAYAMKSEGGYVWACKNYDGDVQSDFLAQGYGSLGMMTSVLVCPD 300
Query: 303 GKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAELV 362
GK E+EAAHGTVTRHYR HQ+G ETSTNSIASIFAW+RGL R KLDS ++ + E +
Sbjct: 301 GKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDSNAALLSYTEKL 360
Query: 363 ESATVNTVQEDEIMTKDLALIL--GKTDRSSYVTTEEFIEAV 402
E+A + TV+ + MTKDLAL++ K R YV TEEFI+AV
Sbjct: 361 EAACMGTVESGK-MTKDLALLIHGAKVRRDQYVNTEEFIDAV 401
>SPAC6G10.08 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 418
Score = 512 bits (1319), Expect = e-145
Identities = 256/407 (62%), Positives = 313/407 (76%), Gaps = 6/407 (1%)
Query: 3 KISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSAQ 62
KI+VK P+VEMDGDE TR+IWK+I++ L+ PY+DI L YYDL IE RD T+D++T +A+
Sbjct: 13 KITVKNPVVEMDGDEMTRVIWKIIREKLVLPYMDIKLDYYDLGIEARDKTNDQITVDAAK 72
Query: 63 ATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLVT 122
A LK V +KCATITPDEARV+E+ LKKMWKSPNGTIRNIL GTVFREPI+I IPK +
Sbjct: 73 AILKNDVGIKCATITPDEARVKEYNLKKMWKSPNGTIRNILNGTVFREPILIKNIPKYIP 132
Query: 123 NWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGGVA 182
W PI IGRHAFGDQY++TD+V G GKL+L F + + +VY+F+ GVA
Sbjct: 133 GWTNPICIGRHAFGDQYKSTDLVASGPGKLELSFTPKGNPSAKETYNVYEFNGS---GVA 189
Query: 183 MAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKSAF 242
M+MYNT +SI GFAH+SF+MAL++ +PLY +TKNTILKKYDG+FKD F+ +YES YK F
Sbjct: 190 MSMYNTDDSIRGFAHSSFQMALQKKMPLYLSTKNTILKKYDGRFKDTFQEVYESDYKQKF 249
Query: 243 EAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPD 302
E G+WY+HRLIDDMVAQ +KS GG++ A KNYDGDV SD+VAQ +GSLGLMTSVLI P+
Sbjct: 250 EELGLWYQHRLIDDMVAQAIKSNGGFVWACKNYDGDVMSDVVAQAYGSLGLMTSVLIHPN 309
Query: 303 GKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAELV 362
G+ FESEAAHGTV RHY Q+ +GK+TSTNSIASIFAWTRGL RG+LD +VKFA +
Sbjct: 310 GRTFESEAAHGTVQRHYMQYLKGKKTSTNSIASIFAWTRGLAHRGRLDGNERLVKFANAL 369
Query: 363 ESATVNTVQEDEIMTKDLALILGKTDRSSYVTTEEFIEAVHKRLDSE 409
E A V V E IMTKDL L+ + YV T EF++AV LDSE
Sbjct: 370 EHACVRCV-EKGIMTKDLYLL--SKSPNGYVDTFEFLDAVKSELDSE 413
>Hs4504575 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 452
Score = 510 bits (1314), Expect = e-144
Identities = 257/409 (62%), Positives = 311/409 (75%), Gaps = 9/409 (2%)
Query: 3 KISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSAQ 62
+I V P+VEMDGDE TRIIW+ IK+ LI P++DI LKY+DL + NRD TDD+VT SA
Sbjct: 43 RIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSAL 102
Query: 63 ATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLVT 122
AT KY VAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPI+ IP+LV
Sbjct: 103 ATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162
Query: 123 NWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGGVA 182
W KPI IGRHA GDQY+ATD V AG K+VF D + E VY+F GGV
Sbjct: 163 GWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVK-EWEVYNFPA---GGVG 218
Query: 183 MAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKSAF 242
M MYNT ESI+GFAH+ F+ A+++ PLY +TKNTILK YDG+FKD+F+ +++ YK+ F
Sbjct: 219 MGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDF 278
Query: 243 EAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPD 302
+ IWYEHRLIDDMVAQ+LKS GG++ A KNYDGDV+SDI+AQGFGSLGLMTSVL+ PD
Sbjct: 279 DKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPD 338
Query: 303 GKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAELV 362
GK E+EAAHGTVTRHYR+HQ+G+ TSTN IASIFAWTRGL RGKLD D+++FA+++
Sbjct: 339 GKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQML 398
Query: 363 ESATVNTVQEDEIMTKDLA-LILGKTD---RSSYVTTEEFIEAVHKRLD 407
E V TV E MTKDLA I G ++ ++ T +F++ + LD
Sbjct: 399 EKVCVETV-ESGAMTKDLAGCIHGLSNVKLNEHFLNTMDFLDTIKSNLD 446
>Hs14729950 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 414
Score = 510 bits (1314), Expect = e-144
Identities = 255/409 (62%), Positives = 316/409 (76%), Gaps = 7/409 (1%)
Query: 1 MSKISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQS 60
MSK +VEM GDE TRIIW+LIK+ LI PY+++DL YDL IENRD T+D+VT+ +
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AQATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKL 120
A+A K+ V VKCATITPDE RVEEFKLK+MWKSPNGTIRNILGGTVFRE I+ IP+L
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTNWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGG 180
V+ W KPIIIGRHA+GDQYRATD V+PG GK+++ + D T+ + V++F+E GG
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDG-TQKVTYLVHNFEEG--GG 177
Query: 181 VAMAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKS 240
VAM MYN +SI FAH+SF+MAL +G PLY +TKNTILKKYDG+FKD+F+ +Y+ QYKS
Sbjct: 178 VAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKS 237
Query: 241 AFEAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLIT 300
FEA+ IWYEHRLIDDMVAQ +KS+GG+I A KNYDGDV+SD VAQG+GSLG+MTSVL+
Sbjct: 238 QFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVC 297
Query: 301 PDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAE 360
PDGK E+EAAHGTVTRHYR +Q+G+ETSTN IASIFAWTRGL R KLD+ ++ FA
Sbjct: 298 PDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFAN 357
Query: 361 LVESATVNTVQEDEIMTKDLALI---LGKTDRSSYVTTEEFIEAVHKRL 406
+E ++ T+ E MTKDLA L RS Y+ T EF++ + + L
Sbjct: 358 ALEEVSIETI-EAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENL 405
>Hs5174471 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 414
Score = 507 bits (1305), Expect = e-143
Identities = 254/409 (62%), Positives = 315/409 (76%), Gaps = 7/409 (1%)
Query: 1 MSKISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQS 60
MSK +VEM GDE TRIIW+LIK+ LI PY+++DL YDL IENRD T+D+VT+ +
Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60
Query: 61 AQATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKL 120
A+A K+ V VKCATITPDE RVEEFKLK+MWKSPNGTIRNILGGTVFRE I+ IP+L
Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120
Query: 121 VTNWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGG 180
V+ W KPIIIGRHA+GDQYRATD V+PG GK+++ + D T+ + V++F+E GG
Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDG-TQKVTYLVHNFEEG--GG 177
Query: 181 VAMAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKS 240
VAM MYN +SI FAH+SF+MAL +G PLY +TKNTILK YDG+FKD+F+ +Y+ QYKS
Sbjct: 178 VAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKIYDGRFKDIFQEIYDKQYKS 237
Query: 241 AFEAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLIT 300
FEA+ IWYEHRLIDDMVAQ +KS+GG+I A KNYDGDV+SD VAQG+GSLG+MTSVL+
Sbjct: 238 QFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVC 297
Query: 301 PDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAE 360
PDGK E+EAAHGTVTRHYR +Q+G+ETSTN IASIFAWTRGL R KLD+ ++ FA
Sbjct: 298 PDGKTVEAEAAHGTVTRHYRMYQKGQETSTNLIASIFAWTRGLAHRAKLDNNKELAFFAN 357
Query: 361 LVESATVNTVQEDEIMTKDLALI---LGKTDRSSYVTTEEFIEAVHKRL 406
+E ++ T+ E MTKDLA L RS Y+ T EF++ + + L
Sbjct: 358 ALEEVSIETI-EAGFMTKDLAACIRGLPNVQRSDYLNTFEFMDKLGENL 405
>CE03436 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 412
Score = 501 bits (1291), Expect = e-142
Identities = 254/403 (63%), Positives = 313/403 (77%), Gaps = 13/403 (3%)
Query: 10 IVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSAQATLKYGV 69
IVEM GDE TRIIW LIK+ LI PY+D+++ ++DL IE+RD TDD+VT +A ATLKY V
Sbjct: 11 IVEMQGDEMTRIIWDLIKEKLILPYVDLNVHFFDLGIEHRDATDDQVTIDAANATLKYNV 70
Query: 70 AVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLVTNWEKPII 129
AVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPI++ +P+LV W KPII
Sbjct: 71 AVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRLVNTWSKPII 130
Query: 130 IGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKG-GVAMAMYNT 188
IGRHA DQY+ATD V+PGAGKL++ F S D T+ I+ +V+DF KG GV+++MYNT
Sbjct: 131 IGRHAHADQYKATDFVVPGAGKLEIKFVSAD-GTQTIQETVFDF----KGPGVSLSMYNT 185
Query: 189 LESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKSAFEAKGIW 248
+SI FAHASFK AL+R PLY +TKNTILKKYDG+FKD+F +Y +Y++ F+A GIW
Sbjct: 186 DDSIRDFAHASFKYALQRKFPLYLSTKNTILKKYDGRFKDIFAEIY-PEYEAEFKAAGIW 244
Query: 249 YEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPDGKAFES 308
YEHRLIDDMVAQ +KS GG++ A KNYDGDV+SD VAQG+GSLGLMTSVL+ PDGK E+
Sbjct: 245 YEHRLIDDMVAQAMKSDGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPDGKTVEA 304
Query: 309 EAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAELVESATVN 368
EAAHGTVTRHYR HQ+G+ETSTN IASIFAW+RGL R LD + FA +E+ +
Sbjct: 305 EAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRATLDKNSALETFANNLEAVCIE 364
Query: 369 TVQEDEIMTKDLALIL-----GKTDRSSYVTTEEFIEAVHKRL 406
T+ E +TKDLA+ + R+ Y+ T EF++ + + L
Sbjct: 365 TM-EAGFLTKDLAICVKGGNASAVTRTDYLNTFEFLDKLAENL 406
>CE15677 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 435
Score = 494 bits (1273), Expect = e-140
Identities = 244/408 (59%), Positives = 312/408 (75%), Gaps = 9/408 (2%)
Query: 3 KISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSAQ 62
KI V P+V++DGDE TRIIWK IK+ LI PYLD+D+KYYDL +E RD T+D+VT +A
Sbjct: 26 KIKVDNPVVDLDGDEMTRIIWKEIKNKLILPYLDLDIKYYDLGLEYRDETNDQVTIDAAH 85
Query: 63 ATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLVT 122
A L++ V +KCATITPDEAR++EF LKKMW SPNGTIRNILGGTVFREPI+ IP+LV
Sbjct: 86 AILEHSVGIKCATITPDEARIKEFNLKKMWLSPNGTIRNILGGTVFREPILCKNIPRLVP 145
Query: 123 NWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGGVA 182
W +PI IGRHAFGDQY+ TD+VIP L+L+ D + + +VYDF + GGV
Sbjct: 146 GWTQPITIGRHAFGDQYKCTDLVIPSGSTLQLLVNKPDGSKD--VHNVYDF--KKSGGVG 201
Query: 183 MAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKSAF 242
+AMYNT ESI GFAH+ F+ AL + PLY +TKNTILKKYDG+FKD+F+ +YE +Y++ F
Sbjct: 202 LAMYNTDESIKGFAHSCFQYALMKQWPLYLSTKNTILKKYDGRFKDIFQDIYEKKYEADF 261
Query: 243 EAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPD 302
+ IWYEHRLIDD VAQ LKS GG++ A KNYDGDV+SDIVAQG+GSLGLM+SVL+ PD
Sbjct: 262 KNNKIWYEHRLIDDQVAQALKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMSSVLMCPD 321
Query: 303 GKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAELV 362
GK E+EAAHGTVTRHYR+HQ+G TSTN IASIFAWTRGL RG LD+ + F+ +
Sbjct: 322 GKTIEAEAAHGTVTRHYREHQKGNSTSTNPIASIFAWTRGLHHRGVLDNNEALKTFSLTL 381
Query: 363 ESATVNTVQEDEIMTKDLALIL----GKTDRSSYVTTEEFIEAVHKRL 406
E A ++TV+E + MTKDL++ + T++ +Y+ TE+F+ A+ ++
Sbjct: 382 EKACIDTVEEGK-MTKDLSICIHGTKKGTEKGAYLITEDFLSAIDTKM 428
>7295108 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 469
Score = 494 bits (1271), Expect = e-139
Identities = 250/404 (61%), Positives = 302/404 (73%), Gaps = 12/404 (2%)
Query: 9 PIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSAQATLKYG 68
P+V++ GDE TRIIW IK LI P+LDI+L YDL IENRD T+D+VT A+A KY
Sbjct: 62 PVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYN 121
Query: 69 VAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLVTNWEKPI 128
V +KCATITPDE RVEEF LKKMWKSPNGTIRNILGGTVFRE I+ +P+LVT W+KPI
Sbjct: 122 VGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPI 181
Query: 129 IIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKG-GVAMAMYN 187
+IGRHA DQY+A D V+PG GKL L ++ D I+ + DF KG G+A+ M+N
Sbjct: 182 VIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQV--IDEVINDF----KGPGIALGMFN 235
Query: 188 TLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKSAFEAKGI 247
T +SI FAHASFK AL+R LPLY +TKNTILKKYDG+FKD+FE LY QYK +EA GI
Sbjct: 236 TDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGI 295
Query: 248 WYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPDGKAFE 307
WYEHRLIDDMVA +KS+GG++ A KNYDGDV+SD VAQG+GSLGLMTSVL+ PDGK E
Sbjct: 296 WYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVE 355
Query: 308 SEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAELVESATV 367
+EAAHGTVTRH+R +QQGKETSTN IASIFAWTRGL+ R KLD+ + +FA+ +E +
Sbjct: 356 AEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCI 415
Query: 368 NTVQEDEIMTKDLALI----LGKTDRSSYVTTEEFIEAVHKRLD 407
+T+ E MTKDLA+ + R Y T EFI + K L+
Sbjct: 416 DTI-ESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLE 458
>Hs17463070 [C] KOG1526 NADP-dependent isocitrate dehydrogenase
Length = 502
Score = 392 bits (1007), Expect = e-109
Identities = 208/409 (50%), Positives = 268/409 (64%), Gaps = 47/409 (11%)
Query: 1 MSKISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQS 60
MSK +VEM GDE T+IIW+L K+ LI PY+++D+ YDL IE D T+D+VT+ +
Sbjct: 94 MSKKISGGSVVEMQGDEMTQIIWELNKEKLIFPYVELDVHSYDLGIEYCDATNDQVTKDA 153
Query: 61 AQATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKL 120
A+A KY V VKCATIT DE RVEEFKLK+MWKSPNGTI+NIL GTV RE I+ IP+L
Sbjct: 154 AEAIKKYNVGVKCATITADEKRVEEFKLKQMWKSPNGTIQNILVGTVLREAIICKNIPQL 213
Query: 121 VTNWEKPIIIGRHAFGDQYRATDVVIPGAGKLKLVFESDDSNTENIELSVYDFDEESKGG 180
V+ W K II+GR A+GDQYRA D V+PG GK+++ + D T+ + +
Sbjct: 214 VSGWVKSIIVGRIAYGDQYRAADFVVPGPGKVEITYTLSD-RTQKVTYLL---------- 262
Query: 181 VAMAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKS 240
+TKNTILKKYDG+FKD+F+ +Y+ QYKS
Sbjct: 263 --------------------------------STKNTILKKYDGRFKDIFQEIYDKQYKS 290
Query: 241 AFEAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLIT 300
FEA+ IWYEHRL DDMVAQ +KS+GG+I A KNYDGD++SD VAQG+GSLG+MTS+L+
Sbjct: 291 QFEAQKIWYEHRLADDMVAQAMKSEGGFIWACKNYDGDMQSDSVAQGYGSLGMMTSMLVC 350
Query: 301 PDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAE 360
P GK E+EAAH TVTRH+ +Q+G+E STN IASIFAWTRGL R K D+ ++ FA
Sbjct: 351 PHGKTVEAEAAHWTVTRHFCMYQKGQEISTNPIASIFAWTRGLALRAKTDNNKELAFFAN 410
Query: 361 LVESATVNTVQEDEIMTKDLALI---LGKTDRSSYVTTEEFIEAVHKRL 406
+E + T+ E MTKDLA L S Y+ T EF++ + + L
Sbjct: 411 ALEEVCIETI-EAGFMTKDLAACIKGLPSAQCSDYLNTFEFMDKLGENL 458
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,443,733
Number of Sequences: 60738
Number of extensions: 1029023
Number of successful extensions: 2916
Number of sequences better than 1.0e-05: 14
Number of HSP's better than 0.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 2880
Number of HSP's gapped (non-prelim): 15
length of query: 415
length of database: 30,389,216
effective HSP length: 109
effective length of query: 306
effective length of database: 23,768,774
effective search space: 7273244844
effective search space used: 7273244844
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)